FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MYBL2-CNBD2 (FusionGDB2 ID:56176)

Fusion Gene Summary for MYBL2-CNBD2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYBL2-CNBD2
Fusion gene ID: 56176
HgeneTgene
Gene symbol

MYBL2

CNBD2

Gene ID

4605

140894

Gene nameMYB proto-oncogene like 2cyclic nucleotide binding domain containing 2
SynonymsB-MYB|BMYBC20orf152|CNMPD1
Cytomap

20q13.12

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionmyb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2cyclic nucleotide-binding domain-containing protein 2cyclic nucleotide (cNMP) binding domain containing 1
Modification date2020031320200313
UniProtAcc

P10244

Q96M20

Ensembl transtripts involved in fusion geneENST00000217026, ENST00000396863, 
ENST00000349339, ENST00000373973, 
ENST00000538900, 
Fusion gene scores* DoF score8 X 8 X 5=32013 X 10 X 11=1430
# samples 917
** MAII scorelog2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1430*10)=-3.07240849552805
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYBL2 [Title/Abstract] AND CNBD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYBL2(42328684)-CNBD2(34582960), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYBL2

GO:0045944

positive regulation of transcription by RNA polymerase II

10770937


check buttonFusion gene breakpoints across MYBL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNBD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3898MYBL2chr20

42328684

+CNBD2chr20

34582960

+


Top

Fusion Gene ORF analysis for MYBL2-CNBD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000217026ENST00000349339MYBL2chr20

42328684

+CNBD2chr20

34582960

+
In-frameENST00000217026ENST00000373973MYBL2chr20

42328684

+CNBD2chr20

34582960

+
In-frameENST00000217026ENST00000538900MYBL2chr20

42328684

+CNBD2chr20

34582960

+
In-frameENST00000396863ENST00000349339MYBL2chr20

42328684

+CNBD2chr20

34582960

+
In-frameENST00000396863ENST00000373973MYBL2chr20

42328684

+CNBD2chr20

34582960

+
In-frameENST00000396863ENST00000538900MYBL2chr20

42328684

+CNBD2chr20

34582960

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396863MYBL2chr2042328684+ENST00000373973CNBD2chr2034582960+197710491701924584
ENST00000396863MYBL2chr2042328684+ENST00000349339CNBD2chr2034582960+196510491701912580
ENST00000396863MYBL2chr2042328684+ENST00000538900CNBD2chr2034582960+177610491701465431
ENST00000217026MYBL2chr2042328684+ENST00000373973CNBD2chr2034582960+200610781271953608
ENST00000217026MYBL2chr2042328684+ENST00000349339CNBD2chr2034582960+199410781271941604
ENST00000217026MYBL2chr2042328684+ENST00000538900CNBD2chr2034582960+180510781271494455

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396863ENST00000373973MYBL2chr2042328684+CNBD2chr2034582960+0.0117134320.98828655
ENST00000396863ENST00000349339MYBL2chr2042328684+CNBD2chr2034582960+0.0125762530.9874237
ENST00000396863ENST00000538900MYBL2chr2042328684+CNBD2chr2034582960+0.0194701160.9805299
ENST00000217026ENST00000373973MYBL2chr2042328684+CNBD2chr2034582960+0.0102763830.98972356
ENST00000217026ENST00000349339MYBL2chr2042328684+CNBD2chr2034582960+0.0111631610.98883677
ENST00000217026ENST00000538900MYBL2chr2042328684+CNBD2chr2034582960+0.017581980.982418

Top

Fusion Genomic Features for MYBL2-CNBD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MYBL2-CNBD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:42328684/chr20:34582960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYBL2

P10244

CNBD2

Q96M20

FUNCTION: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.FUNCTION: Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. {ECO:0000250|UniProtKB:Q9D5U8}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+714106_129317701.0DNA bindingH-T-H motif
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+714157_180317701.0DNA bindingH-T-H motif
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+71454_77317701.0DNA bindingH-T-H motif
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+714134_184317701.0DomainHTH myb-type 3
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+71426_77317701.0DomainHTH myb-type 1
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+71478_133317701.0DomainHTH myb-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+714411_417317701.0MotifNuclear localization signal
HgeneMYBL2chr20:42328684chr20:34582960ENST00000217026+714564_584317701.0MotifNote=Bipartite nuclear localization signal
TgeneCNBD2chr20:42328684chr20:34582960ENST00000349339612116_239285573.0Nucleotide bindingNote=cNMP
TgeneCNBD2chr20:42328684chr20:34582960ENST00000373973612116_239285577.0Nucleotide bindingNote=cNMP
TgeneCNBD2chr20:42328684chr20:34582960ENST00000538900611116_239285424.0Nucleotide bindingNote=cNMP


Top

Fusion Gene Sequence for MYBL2-CNBD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56176_56176_1_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000217026_CNBD2_chr20_34582960_ENST00000349339_length(transcript)=1994nt_BP=1078nt
GCTGACGCCTTCGAGCGCGGCCCGGGGCCCGGAGCGGCCGGAGCAGCCCGGGTCCTGACCCCGGCCCGGCTCCCGCTCCGGGCTCTGCCG
GCGGGCGGGCGAGCGCGGCGCGGTCCGGGCCGGGGGGATGTCTCGGCGGACGCGCTGCGAGGATCTGGATGAGCTGCACTACCAGGACAC
AGATTCAGATGTGCCGGAGCAGAGGGATAGCAAGTGCAAGGTCAAATGGACCCATGAGGAGGACGAGCAGCTGAGGGCCCTGGTGAGGCA
GTTTGGACAGCAGGACTGGAAGTTCCTGGCCAGCCACTTCCCTAACCGCACTGACCAGCAATGCCAGTACAGGTGGCTGAGAGTTTTGAA
TCCAGACCTTGTCAAGGGGCCATGGACCAAAGAGGAAGACCAAAAAGTCATCGAGCTGGTTAAGAAGTATGGCACAAAGCAGTGGACACT
GATTGCCAAGCACCTGAAGGGCCGGCTGGGGAAGCAGTGCCGTGAACGCTGGCACAACCACCTCAACCCTGAGGTGAAGAAGTCTTGCTG
GACCGAGGAGGAGGACCGCATCATCTGCGAGGCCCACAAGGTGCTGGGCAACCGCTGGGCCGAGATCGCCAAGATGTTGCCAGGGAGGAC
AGACAATGCTGTGAAGAATCACTGGAACTCTACCATCAAAAGGAAGGTGGACACAGGAGGCTTCTTGAGCGAGTCCAAAGACTGCAAGCC
CCCAGTGTACTTGCTGCTGGAGCTCGAGGACAAGGACGGCCTCCAGAGTGCCCAGCCCACGGAAGGCCAGGGAAGTCTTCTGACCAACTG
GCCCTCCGTCCCTCCTACCATAAAGGAGGAGGAAAACAGTGAGGAGGAACTTGCAGCAGCCACCACATCGAAGGAACAGGAGCCCATCGG
TACAGATCTGGACGCAGTGCGAACACCAGAGCCCTTGGAGGAATTCCCGAAGCGTGAGGACCAGGAAGGCTCCCCACCAGAAACGAGCCT
GCCTTACAAGTGGGTGGTGGAGGCAGCTAACCTCCTCATCCCTGCTGTGGGTTCTAGCCTCTCTGAAGCCCTGGACTTGATCGAGTCGGG
CAGCTGTGAAGTCCTGCGGCTGTTGGACCTTGGGGCCTCCCCTTCCTACCGTAGATGGATCTGGCAGCACCTGGAGCTGATAGATGGCAG
ACCTCTGAAGACCCACCTGAGTGAATACTCTCCTATGGAAAGATTTAAGGAATTCCAGATCAAATCATATCCTCTGCAAGACTTTAGCTC
CTTGAAACTTCCACATCTCAAAAAAGCCTGGGGGCTACAGGGGACAAGCTTCAGCAGGAAGATCAGAACCTCAGGAGACACTCTCCCCAA
GATGCTGGGCCCGAAGATCCAATCCAGGCCTGCTCAGTCGATCAAATGTGCCATGATCAATATCAAGCCTGGTGAGCTCCCCAAGGAGGC
TGCAGTGGGGGCCTACGTGAAGGTGCACACTGTGGAGCAGGGAGAAATTTTGGCCTTCCTTCCAGAGGGTGAATGCGACACACGACCCTT
GATCCTGATGAGCCTGGGAAATGAGTTGATACGGATAAGGAAGGAAATATTTTATGAACTGATTGACAATGATGACGAGATGATAAAAAA
GTTGTTAAAGCTCAATATTGCATTCCCCAGTGATGAAGATATGTGCCAGAAGTTCCTCCAGCAGAACAGCTGGAATATCTTTCGGAAGGA
CCTGTTGCAGCTGCTCGTGGAGCCTTGCCAAAGTCAACTGTTCACTCCAAACCGGCCCAAGAAGAGAGAGATCTACAACCCTAAGTCTGT
GGTCCTGGATTTGTGCAGCATCAACAAGACGACTAAACCTCGTTATCCTATTTTTATGGCACCCCAGAAATACCTCCCCCCATTGAGGAT
TGTCCAAGCCATCAAAGCACCTCGGTACAAAATCCGAGAACTCTTGGCTTAGTGTAAGAGCACAGGGGTCCTTATTTAGGACAAATAAAG

>56176_56176_1_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000217026_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=604AA_BP=317
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEE
DQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTI
KRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPL
EEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPM
ERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVE
QGEILAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQ

--------------------------------------------------------------
>56176_56176_2_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000217026_CNBD2_chr20_34582960_ENST00000373973_length(transcript)=2006nt_BP=1078nt
GCTGACGCCTTCGAGCGCGGCCCGGGGCCCGGAGCGGCCGGAGCAGCCCGGGTCCTGACCCCGGCCCGGCTCCCGCTCCGGGCTCTGCCG
GCGGGCGGGCGAGCGCGGCGCGGTCCGGGCCGGGGGGATGTCTCGGCGGACGCGCTGCGAGGATCTGGATGAGCTGCACTACCAGGACAC
AGATTCAGATGTGCCGGAGCAGAGGGATAGCAAGTGCAAGGTCAAATGGACCCATGAGGAGGACGAGCAGCTGAGGGCCCTGGTGAGGCA
GTTTGGACAGCAGGACTGGAAGTTCCTGGCCAGCCACTTCCCTAACCGCACTGACCAGCAATGCCAGTACAGGTGGCTGAGAGTTTTGAA
TCCAGACCTTGTCAAGGGGCCATGGACCAAAGAGGAAGACCAAAAAGTCATCGAGCTGGTTAAGAAGTATGGCACAAAGCAGTGGACACT
GATTGCCAAGCACCTGAAGGGCCGGCTGGGGAAGCAGTGCCGTGAACGCTGGCACAACCACCTCAACCCTGAGGTGAAGAAGTCTTGCTG
GACCGAGGAGGAGGACCGCATCATCTGCGAGGCCCACAAGGTGCTGGGCAACCGCTGGGCCGAGATCGCCAAGATGTTGCCAGGGAGGAC
AGACAATGCTGTGAAGAATCACTGGAACTCTACCATCAAAAGGAAGGTGGACACAGGAGGCTTCTTGAGCGAGTCCAAAGACTGCAAGCC
CCCAGTGTACTTGCTGCTGGAGCTCGAGGACAAGGACGGCCTCCAGAGTGCCCAGCCCACGGAAGGCCAGGGAAGTCTTCTGACCAACTG
GCCCTCCGTCCCTCCTACCATAAAGGAGGAGGAAAACAGTGAGGAGGAACTTGCAGCAGCCACCACATCGAAGGAACAGGAGCCCATCGG
TACAGATCTGGACGCAGTGCGAACACCAGAGCCCTTGGAGGAATTCCCGAAGCGTGAGGACCAGGAAGGCTCCCCACCAGAAACGAGCCT
GCCTTACAAGTGGGTGGTGGAGGCAGCTAACCTCCTCATCCCTGCTGTGGGTTCTAGCCTCTCTGAAGCCCTGGACTTGATCGAGTCGGG
CAGCTGTGAAGTCCTGCGGCTGTTGGACCTTGGGGCCTCCCCTTCCTACCGTAGATGGATCTGGCAGCACCTGGAGCTGATAGATGGCAG
ACCTCTGAAGACCCACCTGAGTGAATACTCTCCTATGGAAAGATTTAAGGAATTCCAGATCAAATCATATCCTCTGCAAGACTTTAGCTC
CTTGAAACTTCCACATCTCAAAAAAGCCTGGGGGCTACAGGGGACAAGCTTCAGCAGGAAGATCAGAACCTCAGGAGACACTCTCCCCAA
GATGCTGGGCCCGAAGATCCAATCCAGGCCTGCTCAGTCGATCAAATGTGCCATGATCAATATCAAGCCTGGTGAGCTCCCCAAGGAGGC
TGCAGTGGGGGCCTACGTGAAGGTGCACACTGTGGAGCAGGGAGAAATTTTGGGTCTTCACCAGGCCTTCCTTCCAGAGGGTGAATGCGA
CACACGACCCTTGATCCTGATGAGCCTGGGAAATGAGTTGATACGGATAAGGAAGGAAATATTTTATGAACTGATTGACAATGATGACGA
GATGATAAAAAAGTTGTTAAAGCTCAATATTGCATTCCCCAGTGATGAAGATATGTGCCAGAAGTTCCTCCAGCAGAACAGCTGGAATAT
CTTTCGGAAGGACCTGTTGCAGCTGCTCGTGGAGCCTTGCCAAAGTCAACTGTTCACTCCAAACCGGCCCAAGAAGAGAGAGATCTACAA
CCCTAAGTCTGTGGTCCTGGATTTGTGCAGCATCAACAAGACGACTAAACCTCGTTATCCTATTTTTATGGCACCCCAGAAATACCTCCC
CCCATTGAGGATTGTCCAAGCCATCAAAGCACCTCGGTACAAAATCCGAGAACTCTTGGCTTAGTGTAAGAGCACAGGGGTCCTTATTTA

>56176_56176_2_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000217026_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=608AA_BP=317
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEE
DQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTI
KRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPL
EEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPM
ERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVE
QGEILGLHQAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEP

--------------------------------------------------------------
>56176_56176_3_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000217026_CNBD2_chr20_34582960_ENST00000538900_length(transcript)=1805nt_BP=1078nt
GCTGACGCCTTCGAGCGCGGCCCGGGGCCCGGAGCGGCCGGAGCAGCCCGGGTCCTGACCCCGGCCCGGCTCCCGCTCCGGGCTCTGCCG
GCGGGCGGGCGAGCGCGGCGCGGTCCGGGCCGGGGGGATGTCTCGGCGGACGCGCTGCGAGGATCTGGATGAGCTGCACTACCAGGACAC
AGATTCAGATGTGCCGGAGCAGAGGGATAGCAAGTGCAAGGTCAAATGGACCCATGAGGAGGACGAGCAGCTGAGGGCCCTGGTGAGGCA
GTTTGGACAGCAGGACTGGAAGTTCCTGGCCAGCCACTTCCCTAACCGCACTGACCAGCAATGCCAGTACAGGTGGCTGAGAGTTTTGAA
TCCAGACCTTGTCAAGGGGCCATGGACCAAAGAGGAAGACCAAAAAGTCATCGAGCTGGTTAAGAAGTATGGCACAAAGCAGTGGACACT
GATTGCCAAGCACCTGAAGGGCCGGCTGGGGAAGCAGTGCCGTGAACGCTGGCACAACCACCTCAACCCTGAGGTGAAGAAGTCTTGCTG
GACCGAGGAGGAGGACCGCATCATCTGCGAGGCCCACAAGGTGCTGGGCAACCGCTGGGCCGAGATCGCCAAGATGTTGCCAGGGAGGAC
AGACAATGCTGTGAAGAATCACTGGAACTCTACCATCAAAAGGAAGGTGGACACAGGAGGCTTCTTGAGCGAGTCCAAAGACTGCAAGCC
CCCAGTGTACTTGCTGCTGGAGCTCGAGGACAAGGACGGCCTCCAGAGTGCCCAGCCCACGGAAGGCCAGGGAAGTCTTCTGACCAACTG
GCCCTCCGTCCCTCCTACCATAAAGGAGGAGGAAAACAGTGAGGAGGAACTTGCAGCAGCCACCACATCGAAGGAACAGGAGCCCATCGG
TACAGATCTGGACGCAGTGCGAACACCAGAGCCCTTGGAGGAATTCCCGAAGCGTGAGGACCAGGAAGGCTCCCCACCAGAAACGAGCCT
GCCTTACAAGTGGGTGGTGGAGGCAGCTAACCTCCTCATCCCTGCTGTGGGTTCTAGCCTCTCTGAAGCCCTGGACTTGATCGAGTCGGG
CAGCTGTGAAGTCCTGCGGCTGTTGGACCTTGGGGCCTCCCCTTCCTACCGTAGATGGATCTGGCAGCACCTGGAGCTGATAGATGGCAG
ACCTCTGAAGACCCACCTGAGTGAATACTCTCCTATGGAAAGATTTAAGGAATTCCAGATCAAATCATATCCTCTGCAAGACTTTAGCTC
CTTGAAACTTCCACATCTCAAAAAAGCCTGGGGGCTACAGGGGACAAGCTTCAGCAGGAAGATCAGAACCTCAGGAGACACTCTCCCCAA
GATGCTGGGCCCGAAGATCCAATCCAGGCCTGCTCAGTCGATCAAATGTGCCATGATCAATATCAAGCCTGGTGAGCTCCCCAAGGAGGC
TGCAGTGGGGGCCTACGTGAAGGTGCACACTGTGGAGCAGGGAGAAATTTTGTGATGAAGATATGTGCCAGAAGTTCCTCCAGCAGAACA
GCTGGAATATCTTTCGGAAGGACCTGTTGCAGCTGCTCGTGGAGCCTTGCCAAAGTCAACTGTTCACTCCAAACCGGCCCAAGAAGAGAG
AGATCTACAACCCTAAGTCTGTGGTCCTGGATTTGTGCAGCATCAACAAGACGACTAAACCTCGTTATCCTATTTTTATGGCACCCCAGA
AATACCTCCCCCCATTGAGGATTGTCCAAGCCATCAAAGCACCTCGGTACAAAATCCGAGAACTCTTGGCTTAGTGTAAGAGCACAGGGG

>56176_56176_3_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000217026_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=455AA_BP=317
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEE
DQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTI
KRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPL
EEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPM
ERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVE

--------------------------------------------------------------
>56176_56176_4_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000396863_CNBD2_chr20_34582960_ENST00000349339_length(transcript)=1965nt_BP=1049nt
GACTGCAGTTCCTGCGAGCGAGGAGCGCGGGACCTGCTGACACGCTGACGCCTTCGAGCGCGGCCCGGGGCCCGGAGCGGCCGGAGCAGC
CCGGGTCCTGACCCCGGCCCGGCTCCCGCTCCGGGCTCTGCCGGCGGGCGGGCGAGCGCGGCGCGGTCCGGGCCGGGGGGATGTCTCGGC
GGACGCGCTGCGAGGATCTGGATGAGCTGCACTACCAGGACACAGATTCAGATGTGCCGGAGCAGAGGGATAGCAAGTGCAAGGTCAAAT
GGACCCATGAGGAGAACCGCACTGACCAGCAATGCCAGTACAGGTGGCTGAGAGTTTTGAATCCAGACCTTGTCAAGGGGCCATGGACCA
AAGAGGAAGACCAAAAAGTCATCGAGCTGGTTAAGAAGTATGGCACAAAGCAGTGGACACTGATTGCCAAGCACCTGAAGGGCCGGCTGG
GGAAGCAGTGCCGTGAACGCTGGCACAACCACCTCAACCCTGAGGTGAAGAAGTCTTGCTGGACCGAGGAGGAGGACCGCATCATCTGCG
AGGCCCACAAGGTGCTGGGCAACCGCTGGGCCGAGATCGCCAAGATGTTGCCAGGGAGGACAGACAATGCTGTGAAGAATCACTGGAACT
CTACCATCAAAAGGAAGGTGGACACAGGAGGCTTCTTGAGCGAGTCCAAAGACTGCAAGCCCCCAGTGTACTTGCTGCTGGAGCTCGAGG
ACAAGGACGGCCTCCAGAGTGCCCAGCCCACGGAAGGCCAGGGAAGTCTTCTGACCAACTGGCCCTCCGTCCCTCCTACCATAAAGGAGG
AGGAAAACAGTGAGGAGGAACTTGCAGCAGCCACCACATCGAAGGAACAGGAGCCCATCGGTACAGATCTGGACGCAGTGCGAACACCAG
AGCCCTTGGAGGAATTCCCGAAGCGTGAGGACCAGGAAGGCTCCCCACCAGAAACGAGCCTGCCTTACAAGTGGGTGGTGGAGGCAGCTA
ACCTCCTCATCCCTGCTGTGGGTTCTAGCCTCTCTGAAGCCCTGGACTTGATCGAGTCGGGCAGCTGTGAAGTCCTGCGGCTGTTGGACC
TTGGGGCCTCCCCTTCCTACCGTAGATGGATCTGGCAGCACCTGGAGCTGATAGATGGCAGACCTCTGAAGACCCACCTGAGTGAATACT
CTCCTATGGAAAGATTTAAGGAATTCCAGATCAAATCATATCCTCTGCAAGACTTTAGCTCCTTGAAACTTCCACATCTCAAAAAAGCCT
GGGGGCTACAGGGGACAAGCTTCAGCAGGAAGATCAGAACCTCAGGAGACACTCTCCCCAAGATGCTGGGCCCGAAGATCCAATCCAGGC
CTGCTCAGTCGATCAAATGTGCCATGATCAATATCAAGCCTGGTGAGCTCCCCAAGGAGGCTGCAGTGGGGGCCTACGTGAAGGTGCACA
CTGTGGAGCAGGGAGAAATTTTGGCCTTCCTTCCAGAGGGTGAATGCGACACACGACCCTTGATCCTGATGAGCCTGGGAAATGAGTTGA
TACGGATAAGGAAGGAAATATTTTATGAACTGATTGACAATGATGACGAGATGATAAAAAAGTTGTTAAAGCTCAATATTGCATTCCCCA
GTGATGAAGATATGTGCCAGAAGTTCCTCCAGCAGAACAGCTGGAATATCTTTCGGAAGGACCTGTTGCAGCTGCTCGTGGAGCCTTGCC
AAAGTCAACTGTTCACTCCAAACCGGCCCAAGAAGAGAGAGATCTACAACCCTAAGTCTGTGGTCCTGGATTTGTGCAGCATCAACAAGA
CGACTAAACCTCGTTATCCTATTTTTATGGCACCCCAGAAATACCTCCCCCCATTGAGGATTGTCCAAGCCATCAAAGCACCTCGGTACA

>56176_56176_4_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000396863_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=580AA_BP=293
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEENRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLK
GRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLL
ELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVV
EAANLLIPAVGSSLSEALDLIESGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHL
KKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLPEGECDTRPLILMSLG
NELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCS

--------------------------------------------------------------
>56176_56176_5_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000396863_CNBD2_chr20_34582960_ENST00000373973_length(transcript)=1977nt_BP=1049nt
GACTGCAGTTCCTGCGAGCGAGGAGCGCGGGACCTGCTGACACGCTGACGCCTTCGAGCGCGGCCCGGGGCCCGGAGCGGCCGGAGCAGC
CCGGGTCCTGACCCCGGCCCGGCTCCCGCTCCGGGCTCTGCCGGCGGGCGGGCGAGCGCGGCGCGGTCCGGGCCGGGGGGATGTCTCGGC
GGACGCGCTGCGAGGATCTGGATGAGCTGCACTACCAGGACACAGATTCAGATGTGCCGGAGCAGAGGGATAGCAAGTGCAAGGTCAAAT
GGACCCATGAGGAGAACCGCACTGACCAGCAATGCCAGTACAGGTGGCTGAGAGTTTTGAATCCAGACCTTGTCAAGGGGCCATGGACCA
AAGAGGAAGACCAAAAAGTCATCGAGCTGGTTAAGAAGTATGGCACAAAGCAGTGGACACTGATTGCCAAGCACCTGAAGGGCCGGCTGG
GGAAGCAGTGCCGTGAACGCTGGCACAACCACCTCAACCCTGAGGTGAAGAAGTCTTGCTGGACCGAGGAGGAGGACCGCATCATCTGCG
AGGCCCACAAGGTGCTGGGCAACCGCTGGGCCGAGATCGCCAAGATGTTGCCAGGGAGGACAGACAATGCTGTGAAGAATCACTGGAACT
CTACCATCAAAAGGAAGGTGGACACAGGAGGCTTCTTGAGCGAGTCCAAAGACTGCAAGCCCCCAGTGTACTTGCTGCTGGAGCTCGAGG
ACAAGGACGGCCTCCAGAGTGCCCAGCCCACGGAAGGCCAGGGAAGTCTTCTGACCAACTGGCCCTCCGTCCCTCCTACCATAAAGGAGG
AGGAAAACAGTGAGGAGGAACTTGCAGCAGCCACCACATCGAAGGAACAGGAGCCCATCGGTACAGATCTGGACGCAGTGCGAACACCAG
AGCCCTTGGAGGAATTCCCGAAGCGTGAGGACCAGGAAGGCTCCCCACCAGAAACGAGCCTGCCTTACAAGTGGGTGGTGGAGGCAGCTA
ACCTCCTCATCCCTGCTGTGGGTTCTAGCCTCTCTGAAGCCCTGGACTTGATCGAGTCGGGCAGCTGTGAAGTCCTGCGGCTGTTGGACC
TTGGGGCCTCCCCTTCCTACCGTAGATGGATCTGGCAGCACCTGGAGCTGATAGATGGCAGACCTCTGAAGACCCACCTGAGTGAATACT
CTCCTATGGAAAGATTTAAGGAATTCCAGATCAAATCATATCCTCTGCAAGACTTTAGCTCCTTGAAACTTCCACATCTCAAAAAAGCCT
GGGGGCTACAGGGGACAAGCTTCAGCAGGAAGATCAGAACCTCAGGAGACACTCTCCCCAAGATGCTGGGCCCGAAGATCCAATCCAGGC
CTGCTCAGTCGATCAAATGTGCCATGATCAATATCAAGCCTGGTGAGCTCCCCAAGGAGGCTGCAGTGGGGGCCTACGTGAAGGTGCACA
CTGTGGAGCAGGGAGAAATTTTGGGTCTTCACCAGGCCTTCCTTCCAGAGGGTGAATGCGACACACGACCCTTGATCCTGATGAGCCTGG
GAAATGAGTTGATACGGATAAGGAAGGAAATATTTTATGAACTGATTGACAATGATGACGAGATGATAAAAAAGTTGTTAAAGCTCAATA
TTGCATTCCCCAGTGATGAAGATATGTGCCAGAAGTTCCTCCAGCAGAACAGCTGGAATATCTTTCGGAAGGACCTGTTGCAGCTGCTCG
TGGAGCCTTGCCAAAGTCAACTGTTCACTCCAAACCGGCCCAAGAAGAGAGAGATCTACAACCCTAAGTCTGTGGTCCTGGATTTGTGCA
GCATCAACAAGACGACTAAACCTCGTTATCCTATTTTTATGGCACCCCAGAAATACCTCCCCCCATTGAGGATTGTCCAAGCCATCAAAG

>56176_56176_5_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000396863_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=584AA_BP=293
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEENRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLK
GRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLL
ELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVV
EAANLLIPAVGSSLSEALDLIESGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHL
KKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAFLPEGECDTRPLIL
MSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVL

--------------------------------------------------------------
>56176_56176_6_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000396863_CNBD2_chr20_34582960_ENST00000538900_length(transcript)=1776nt_BP=1049nt
GACTGCAGTTCCTGCGAGCGAGGAGCGCGGGACCTGCTGACACGCTGACGCCTTCGAGCGCGGCCCGGGGCCCGGAGCGGCCGGAGCAGC
CCGGGTCCTGACCCCGGCCCGGCTCCCGCTCCGGGCTCTGCCGGCGGGCGGGCGAGCGCGGCGCGGTCCGGGCCGGGGGGATGTCTCGGC
GGACGCGCTGCGAGGATCTGGATGAGCTGCACTACCAGGACACAGATTCAGATGTGCCGGAGCAGAGGGATAGCAAGTGCAAGGTCAAAT
GGACCCATGAGGAGAACCGCACTGACCAGCAATGCCAGTACAGGTGGCTGAGAGTTTTGAATCCAGACCTTGTCAAGGGGCCATGGACCA
AAGAGGAAGACCAAAAAGTCATCGAGCTGGTTAAGAAGTATGGCACAAAGCAGTGGACACTGATTGCCAAGCACCTGAAGGGCCGGCTGG
GGAAGCAGTGCCGTGAACGCTGGCACAACCACCTCAACCCTGAGGTGAAGAAGTCTTGCTGGACCGAGGAGGAGGACCGCATCATCTGCG
AGGCCCACAAGGTGCTGGGCAACCGCTGGGCCGAGATCGCCAAGATGTTGCCAGGGAGGACAGACAATGCTGTGAAGAATCACTGGAACT
CTACCATCAAAAGGAAGGTGGACACAGGAGGCTTCTTGAGCGAGTCCAAAGACTGCAAGCCCCCAGTGTACTTGCTGCTGGAGCTCGAGG
ACAAGGACGGCCTCCAGAGTGCCCAGCCCACGGAAGGCCAGGGAAGTCTTCTGACCAACTGGCCCTCCGTCCCTCCTACCATAAAGGAGG
AGGAAAACAGTGAGGAGGAACTTGCAGCAGCCACCACATCGAAGGAACAGGAGCCCATCGGTACAGATCTGGACGCAGTGCGAACACCAG
AGCCCTTGGAGGAATTCCCGAAGCGTGAGGACCAGGAAGGCTCCCCACCAGAAACGAGCCTGCCTTACAAGTGGGTGGTGGAGGCAGCTA
ACCTCCTCATCCCTGCTGTGGGTTCTAGCCTCTCTGAAGCCCTGGACTTGATCGAGTCGGGCAGCTGTGAAGTCCTGCGGCTGTTGGACC
TTGGGGCCTCCCCTTCCTACCGTAGATGGATCTGGCAGCACCTGGAGCTGATAGATGGCAGACCTCTGAAGACCCACCTGAGTGAATACT
CTCCTATGGAAAGATTTAAGGAATTCCAGATCAAATCATATCCTCTGCAAGACTTTAGCTCCTTGAAACTTCCACATCTCAAAAAAGCCT
GGGGGCTACAGGGGACAAGCTTCAGCAGGAAGATCAGAACCTCAGGAGACACTCTCCCCAAGATGCTGGGCCCGAAGATCCAATCCAGGC
CTGCTCAGTCGATCAAATGTGCCATGATCAATATCAAGCCTGGTGAGCTCCCCAAGGAGGCTGCAGTGGGGGCCTACGTGAAGGTGCACA
CTGTGGAGCAGGGAGAAATTTTGTGATGAAGATATGTGCCAGAAGTTCCTCCAGCAGAACAGCTGGAATATCTTTCGGAAGGACCTGTTG
CAGCTGCTCGTGGAGCCTTGCCAAAGTCAACTGTTCACTCCAAACCGGCCCAAGAAGAGAGAGATCTACAACCCTAAGTCTGTGGTCCTG
GATTTGTGCAGCATCAACAAGACGACTAAACCTCGTTATCCTATTTTTATGGCACCCCAGAAATACCTCCCCCCATTGAGGATTGTCCAA

>56176_56176_6_MYBL2-CNBD2_MYBL2_chr20_42328684_ENST00000396863_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=431AA_BP=293
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEENRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLK
GRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLL
ELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVV
EAANLLIPAVGSSLSEALDLIESGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MYBL2-CNBD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MYBL2-CNBD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MYBL2-CNBD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource