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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYH10-CDKN2A (FusionGDB2 ID:56273)

Fusion Gene Summary for MYH10-CDKN2A

check button Fusion gene summary
Fusion gene informationFusion gene name: MYH10-CDKN2A
Fusion gene ID: 56273
HgeneTgene
Gene symbol

MYH10

CDKN2A

Gene ID

4628

1029

Gene namemyosin heavy chain 10cyclin dependent kinase inhibitor 2A
SynonymsNMMHC-IIB|NMMHCBARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16
Cytomap

17p13.1

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionmyosin-10cellular myosin heavy chain, type Bmyosin heavy chain, nonmuscle type Bmyosin, heavy chain 10, non-musclemyosin, heavy polypeptide 10, non-musclenonmuscle myosin II heavy chain-Bnonmuscle myosin heavy chain IIBcyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1
Modification date2020031320200329
UniProtAcc.

Q96HQ2

Ensembl transtripts involved in fusion geneENST00000269243, ENST00000360416, 
ENST00000379980, ENST00000396239, 
ENST00000446177, ENST00000479692, 
ENST00000494262, ENST00000497750, 
ENST00000498124, ENST00000498628, 
ENST00000530628, ENST00000578845, 
ENST00000470819, ENST00000304494, 
ENST00000579122, ENST00000361570, 
ENST00000579755, 
Fusion gene scores* DoF score12 X 15 X 5=90013 X 5 X 10=650
# samples 1516
** MAII scorelog2(15/900*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/650*10)=-2.02236781302845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYH10 [Title/Abstract] AND CDKN2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDKN2A(21994138)-MYH10(8508300), # samples:2
MYH10(8526220)-CDKN2A(21971207), # samples:2
Anticipated loss of major functional domain due to fusion event.MYH10-CDKN2A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MYH10-CDKN2A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYH10

GO:0000281

mitotic cytokinesis

15774463

HgeneMYH10

GO:0030048

actin filament-based movement

15845534

TgeneCDKN2A

GO:0000082

G1/S transition of mitotic cell cycle

10208428

TgeneCDKN2A

GO:0007050

cell cycle arrest

15149599

TgeneCDKN2A

GO:0008285

negative regulation of cell proliferation

15149599

TgeneCDKN2A

GO:0030308

negative regulation of cell growth

10208428

TgeneCDKN2A

GO:0032088

negative regulation of NF-kappaB transcription factor activity

10353611

TgeneCDKN2A

GO:0042326

negative regulation of phosphorylation

8259215|10208428

TgeneCDKN2A

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

7739547|8259215


check buttonFusion gene breakpoints across MYH10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDKN2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-SI-A71P-01AMYH10chr17

8526220

-CDKN2Achr9

21971207

-
ChimerDB4SARCTCGA-SI-A71PMYH10chr17

8526219

-CDKN2Achr9

21971207

-


Top

Fusion Gene ORF analysis for MYH10-CDKN2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000269243ENST00000446177MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000446177MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000479692MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000479692MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000494262MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000494262MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000497750MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000497750MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000498124MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000498124MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000498628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000498628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000530628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000530628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000578845MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000269243ENST00000578845MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000446177MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000446177MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000479692MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000479692MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000494262MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000494262MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000497750MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000497750MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000498124MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000498124MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000498628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000498628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000530628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000530628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000578845MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000360416ENST00000578845MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000446177MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000446177MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000479692MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000479692MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000494262MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000494262MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000497750MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000497750MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000498124MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000498124MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000498628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000498628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000530628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000530628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000578845MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000379980ENST00000578845MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000446177MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000446177MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000479692MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000479692MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000494262MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000494262MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000497750MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000497750MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000498124MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000498124MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000498628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000498628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000530628MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000530628MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000578845MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000396239ENST00000578845MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-intronENST00000269243ENST00000470819MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-intronENST00000269243ENST00000470819MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-intronENST00000360416ENST00000470819MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-intronENST00000360416ENST00000470819MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-intronENST00000379980ENST00000470819MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-intronENST00000379980ENST00000470819MYH10chr17

8526219

-CDKN2Achr9

21971207

-
5CDS-intronENST00000396239ENST00000470819MYH10chr17

8526220

-CDKN2Achr9

21971207

-
5CDS-intronENST00000396239ENST00000470819MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000269243ENST00000304494MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000269243ENST00000304494MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000269243ENST00000579122MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000269243ENST00000579122MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000360416ENST00000304494MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000360416ENST00000304494MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000360416ENST00000579122MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000360416ENST00000579122MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000379980ENST00000304494MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000379980ENST00000304494MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000379980ENST00000579122MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000379980ENST00000579122MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000396239ENST00000304494MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000396239ENST00000304494MYH10chr17

8526219

-CDKN2Achr9

21971207

-
Frame-shiftENST00000396239ENST00000579122MYH10chr17

8526220

-CDKN2Achr9

21971207

-
Frame-shiftENST00000396239ENST00000579122MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000269243ENST00000361570MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000269243ENST00000361570MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000269243ENST00000579755MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000269243ENST00000579755MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000360416ENST00000361570MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000360416ENST00000361570MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000360416ENST00000579755MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000360416ENST00000579755MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000379980ENST00000361570MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000379980ENST00000361570MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000379980ENST00000579755MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000379980ENST00000579755MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000396239ENST00000361570MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000396239ENST00000361570MYH10chr17

8526219

-CDKN2Achr9

21971207

-
In-frameENST00000396239ENST00000579755MYH10chr17

8526220

-CDKN2Achr9

21971207

-
In-frameENST00000396239ENST00000579755MYH10chr17

8526219

-CDKN2Achr9

21971207

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360416MYH10chr178526220-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000360416MYH10chr178526220-ENST00000579755CDKN2Achr921971207-1281484139804221
ENST00000379980MYH10chr178526220-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000379980MYH10chr178526220-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000396239MYH10chr178526220-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000396239MYH10chr178526220-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000269243MYH10chr178526220-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000269243MYH10chr178526220-ENST00000579755CDKN2Achr921971207-1281484139804221
ENST00000360416MYH10chr178526219-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000360416MYH10chr178526219-ENST00000579755CDKN2Achr921971207-1281484139804221
ENST00000379980MYH10chr178526219-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000379980MYH10chr178526219-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000396239MYH10chr178526219-ENST00000361570CDKN2Achr921971207-123944196761221
ENST00000396239MYH10chr178526219-ENST00000579755CDKN2Achr921971207-123844196761221
ENST00000269243MYH10chr178526219-ENST00000361570CDKN2Achr921971207-1282484139804221
ENST00000269243MYH10chr178526219-ENST00000579755CDKN2Achr921971207-1281484139804221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360416ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0023159420.997684
ENST00000360416ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0023075390.99769247
ENST00000379980ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0021275340.9978725
ENST00000379980ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0021185770.99788135
ENST00000396239ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0021275340.9978725
ENST00000396239ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0021185770.99788135
ENST00000269243ENST00000361570MYH10chr178526220-CDKN2Achr921971207-0.0023159420.997684
ENST00000269243ENST00000579755MYH10chr178526220-CDKN2Achr921971207-0.0023075390.99769247
ENST00000360416ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0023159420.997684
ENST00000360416ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0023075390.99769247
ENST00000379980ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0021275340.9978725
ENST00000379980ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0021185770.99788135
ENST00000396239ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0021275340.9978725
ENST00000396239ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0021185770.99788135
ENST00000269243ENST00000361570MYH10chr178526219-CDKN2Achr921971207-0.0023159420.997684
ENST00000269243ENST00000579755MYH10chr178526219-CDKN2Achr921971207-0.0023075390.99769247

Top

Fusion Genomic Features for MYH10-CDKN2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYH10-CDKN2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:21994138/chr9:8508300)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDKN2A

Q96HQ2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-24131_811151977.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-24331_811152008.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-24231_811151998.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-24131_811151977.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-24331_811152008.0DomainMyosin N-terminal SH3-like
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-24231_811151998.0DomainMyosin N-terminal SH3-like
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000030449403110_13950157.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000003044940377_10650157.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000044617703110_13950168.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004461770377_10650168.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000049426214110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004942621411_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004942621444_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004942621477_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000049812404110_13950130.66666666666666RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004981240477_10650130.66666666666666RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000049862803110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004986280311_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004986280344_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004986280377_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526219chr9:21971207ENST0000057884502110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526219chr9:21971207ENST000005788450211_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000005788450244_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000005788450277_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000030449403110_13950157.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000003044940377_10650157.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000044617703110_13950168.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004461770377_10650168.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000049426214110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004942621411_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004942621444_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004942621477_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000049812404110_13950130.66666666666666RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004981240477_10650130.66666666666666RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000049862803110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004986280311_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004986280344_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004986280377_1060106.0RepeatNote=ANK 3
TgeneCDKN2Achr17:8526220chr9:21971207ENST0000057884502110_1390106.0RepeatNote=ANK 4
TgeneCDKN2Achr17:8526220chr9:21971207ENST000005788450211_400106.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000005788450244_720106.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000005788450277_1060106.0RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241845_19761151977.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243845_19761152008.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242845_19761151998.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241845_19761151977.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243845_19761152008.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242845_19761151998.0Coiled coilOntology_term=ECO:0000255
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241786_8151151977.0DomainIQ
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-24185_7831151977.0DomainMyosin motor
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243786_8151152008.0DomainIQ
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-24385_7831152008.0DomainMyosin motor
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242786_8151151998.0DomainIQ
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-24285_7831151998.0DomainMyosin motor
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241786_8151151977.0DomainIQ
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-24185_7831151977.0DomainMyosin motor
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243786_8151152008.0DomainIQ
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-24385_7831152008.0DomainMyosin motor
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242786_8151151998.0DomainIQ
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-24285_7831151998.0DomainMyosin motor
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241178_1851151977.0Nucleotide bindingATP
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243178_1851152008.0Nucleotide bindingATP
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242178_1851151998.0Nucleotide bindingATP
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241178_1851151977.0Nucleotide bindingATP
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243178_1851152008.0Nucleotide bindingATP
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242178_1851151998.0Nucleotide bindingATP
HgeneMYH10chr17:8526219chr9:21971207ENST00000269243-241661_6831151977.0RegionActin-binding
HgeneMYH10chr17:8526219chr9:21971207ENST00000360416-243661_6831152008.0RegionActin-binding
HgeneMYH10chr17:8526219chr9:21971207ENST00000396239-242661_6831151998.0RegionActin-binding
HgeneMYH10chr17:8526220chr9:21971207ENST00000269243-241661_6831151977.0RegionActin-binding
HgeneMYH10chr17:8526220chr9:21971207ENST00000360416-243661_6831152008.0RegionActin-binding
HgeneMYH10chr17:8526220chr9:21971207ENST00000396239-242661_6831151998.0RegionActin-binding
TgeneCDKN2Achr17:8526219chr9:21971207ENST000003044940311_4050157.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000003044940344_7250157.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004461770311_4050168.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004461770344_7250168.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004981240411_4050130.66666666666666RepeatNote=ANK 1
TgeneCDKN2Achr17:8526219chr9:21971207ENST000004981240444_7250130.66666666666666RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000003044940311_4050157.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000003044940344_7250157.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004461770311_4050168.0RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004461770344_7250168.0RepeatNote=ANK 2
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004981240411_4050130.66666666666666RepeatNote=ANK 1
TgeneCDKN2Achr17:8526220chr9:21971207ENST000004981240444_7250130.66666666666666RepeatNote=ANK 2


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Fusion Gene Sequence for MYH10-CDKN2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56273_56273_1_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000269243_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1282nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_1_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000269243_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_2_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000269243_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1281nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_2_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000269243_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_3_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000360416_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1282nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_3_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000360416_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_4_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000360416_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1281nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_4_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000360416_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_5_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000379980_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1239nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_5_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000379980_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_6_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000379980_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1238nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_6_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000379980_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_7_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000396239_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1239nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_7_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000396239_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_8_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000396239_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1238nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_8_MYH10-CDKN2A_MYH10_chr17_8526219_ENST00000396239_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_9_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000269243_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1282nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_9_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000269243_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_10_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000269243_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1281nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_10_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000269243_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_11_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000360416_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1282nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_11_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000360416_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_12_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000360416_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1281nt_BP=484nt
AGCAGTGCTAAAGGAGCCCGGCGGAGGCAGCGGTGGGTTTGGGACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGC
CACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCATTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCT
CTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCTGATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGG
TTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTTATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGA
TGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAGGATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAA
TCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA
GCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCG
GGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTA
CCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAA
CCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCC
CGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATG
TCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGA
GTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATT
TTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAAAAATAAA

>56273_56273_12_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000360416_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_13_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000379980_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1239nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_13_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000379980_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_14_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000379980_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1238nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_14_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000379980_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_15_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000396239_CDKN2A_chr9_21971207_ENST00000361570_length(transcript)=1239nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_15_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000396239_CDKN2A_chr9_21971207_ENST00000361570_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------
>56273_56273_16_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000396239_CDKN2A_chr9_21971207_ENST00000579755_length(transcript)=1238nt_BP=441nt
ACTGAGGCGCTGGATCTGTGGTCGCGGCTGGGGACGTGCGCCCGCGCCACCATCTTCGGCTGAAGAGGCAATTGCTTTTGGATCGTTCCA
TTTACAATGGCGCAGAGAACTGGACTCGAGGATCCAGAGAGGTATCTCTTTGTGGACAGGGCTGTCATCTACAACCCTGCCACTCAAGCT
GATTGGACAGCTAAAAAGCTAGTGTGGATTCCATCAGAACGCCATGGTTTTGAGGCAGCTAGTATCAAAGAAGAACGGGGAGATGAAGTT
ATGGTGGAGTTGGCAGAGAATGGAAAGAAAGCAATGGTCAACAAAGATGATATTCAGAAGATGAACCCACCTAAGTTTTCCAAGGTGGAG
GATATGGCAGAATTGACATGCTTGAATGAAGCTTCCGTTTTACATAATCTGAAGGATCGCTACTATTCAGGACTAATCTATGTCATGATG
ATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCAC
GACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTG
CCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCC
CGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGT
CACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATG
TCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACCGTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAA
AAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTTTTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCT
TGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGACAAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGA

>56273_56273_16_MYH10-CDKN2A_MYH10_chr17_8526220_ENST00000396239_CDKN2A_chr9_21971207_ENST00000579755_length(amino acids)=221AA_BP=115
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDM
AELTCLNEASVLHNLKDRYYSGLIYVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYH10-CDKN2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCDKN2Achr17:8526219chr9:21971207ENST00000361570031_64105.33333333333333220.0CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526219chr9:21971207ENST00000530628031_6464.33333333333333122.66666666666667CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526219chr9:21971207ENST00000579755031_6464.33333333333333134.33333333333334CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526220chr9:21971207ENST00000361570031_64105.33333333333333220.0CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526220chr9:21971207ENST00000530628031_6464.33333333333333122.66666666666667CDK5RAP3 and MDM2
TgeneCDKN2Achr17:8526220chr9:21971207ENST00000579755031_6464.33333333333333134.33333333333334CDK5RAP3 and MDM2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYH10-CDKN2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYH10-CDKN2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource