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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYH11-APOBEC3G (FusionGDB2 ID:56283)

Fusion Gene Summary for MYH11-APOBEC3G

check button Fusion gene summary
Fusion gene informationFusion gene name: MYH11-APOBEC3G
Fusion gene ID: 56283
HgeneTgene
Gene symbol

MYH11

APOBEC3G

Gene ID

4629

60489

Gene namemyosin heavy chain 11apolipoprotein B mRNA editing enzyme catalytic subunit 3G
SynonymsAAT4|FAA4|SMHC|SMMHCA3G|ARCD|ARP-9|ARP9|CEM-15|CEM15|MDS019|bK150C2.7|dJ494G10.1
Cytomap

16p13.11

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionmyosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscleDNA dC->dU-editing enzyme APOBEC-3GAPOBEC-related cytidine deaminaseAPOBEC-related protein 9DNA dC->dU editing enzymeapolipoprotein B editing enzyme catalytic polypeptide-like 3Gapolipoprotein B mRNA editing enzyme cytidine deaminaseapolipoprotein B
Modification date2020032220200313
UniProtAcc

P35749

.
Ensembl transtripts involved in fusion geneENST00000300036, ENST00000396324, 
ENST00000452625, ENST00000576790, 
ENST00000573908, 		ENST00000461827, 
ENST00000407997, ENST00000452957, 
Fusion gene scores* DoF score31 X 31 X 8=76883 X 3 X 2=18
# samples 323
** MAII scorelog2(32/7688*10)=-4.58646452588639
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYH11 [Title/Abstract] AND APOBEC3G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYH11(15931765)-APOBEC3G(39482284), # samples:1
Anticipated loss of major functional domain due to fusion event.MYH11-APOBEC3G seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MYH11-APOBEC3G seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPOBEC3G

GO:0002230

positive regulation of defense response to virus by host

17121840

TgeneAPOBEC3G

GO:0009972

cytidine deamination

16378963

TgeneAPOBEC3G

GO:0010529

negative regulation of transposition

16527742

TgeneAPOBEC3G

GO:0045071

negative regulation of viral genome replication

16378963|17121840

TgeneAPOBEC3G

GO:0045087

innate immune response

17121840

TgeneAPOBEC3G

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

16571802|17121840|21835787

TgeneAPOBEC3G

GO:0048525

negative regulation of viral process

17121840

TgeneAPOBEC3G

GO:0051607

defense response to virus

12808465|21835787|22915799

TgeneAPOBEC3G

GO:0070383

DNA cytosine deamination

16527742|16571802|21835787


check buttonFusion gene breakpoints across MYH11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APOBEC3G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-5100-01AMYH11chr16

15931765

-APOBEC3Gchr22

39482284

+


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Fusion Gene ORF analysis for MYH11-APOBEC3G

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000300036ENST00000461827MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
5CDS-intronENST00000396324ENST00000461827MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
5CDS-intronENST00000452625ENST00000461827MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
5CDS-intronENST00000576790ENST00000461827MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
Frame-shiftENST00000300036ENST00000407997MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
Frame-shiftENST00000300036ENST00000452957MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
Frame-shiftENST00000396324ENST00000407997MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
Frame-shiftENST00000396324ENST00000452957MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
In-frameENST00000452625ENST00000407997MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
In-frameENST00000452625ENST00000452957MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
In-frameENST00000576790ENST00000407997MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
In-frameENST00000576790ENST00000452957MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
intron-3CDSENST00000573908ENST00000407997MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
intron-3CDSENST00000573908ENST00000452957MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+
intron-intronENST00000573908ENST00000461827MYH11chr16

15931765

-APOBEC3Gchr22

39482284

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000452625MYH11chr1615931765-ENST00000452957APOBEC3Gchr2239482284+116243361852263
ENST00000452625MYH11chr1615931765-ENST00000407997APOBEC3Gchr2239482284+117543361852263
ENST00000576790MYH11chr1615931765-ENST00000452957APOBEC3Gchr2239482284+118445583874263
ENST00000576790MYH11chr1615931765-ENST00000407997APOBEC3Gchr2239482284+119745583874263

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000452625ENST00000452957MYH11chr1615931765-APOBEC3Gchr2239482284+0.0061855170.99381447
ENST00000452625ENST00000407997MYH11chr1615931765-APOBEC3Gchr2239482284+0.0061862050.99381375
ENST00000576790ENST00000452957MYH11chr1615931765-APOBEC3Gchr2239482284+0.00598430.9940157
ENST00000576790ENST00000407997MYH11chr1615931765-APOBEC3Gchr2239482284+0.0059322950.99406767

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Fusion Genomic Features for MYH11-APOBEC3G


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYH11-APOBEC3G


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:15931765/chr22:39482284)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYH11

P35749

.
FUNCTION: Muscle contraction.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-24131_811151973.0DomainMyosin N-terminal SH3-like
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-24231_811151980.0DomainMyosin N-terminal SH3-like
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-24331_811152132.0DomainMyosin N-terminal SH3-like
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-24231_811151912.6666666666667DomainMyosin N-terminal SH3-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-241844_19341151973.0Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-242844_19341151980.0Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-243844_19341152132.0Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-242844_19341151912.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-241786_8151151973.0DomainIQ
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-24185_7831151973.0DomainMyosin motor
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-242786_8151151980.0DomainIQ
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-24285_7831151980.0DomainMyosin motor
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-243786_8151152132.0DomainIQ
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-24385_7831152132.0DomainMyosin motor
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-242786_8151151912.6666666666667DomainIQ
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-24285_7831151912.6666666666667DomainMyosin motor
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-241178_1851151973.0Nucleotide bindingATP
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-242178_1851151980.0Nucleotide bindingATP
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-243178_1851152132.0Nucleotide bindingATP
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-242178_1851151912.6666666666667Nucleotide bindingATP
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-2411935_19721151973.0RegionNote=C-terminal
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-241661_6831151973.0RegionActin-binding
HgeneMYH11chr16:15931765chr22:39482284ENST00000300036-241762_7761151973.0RegionActin-binding
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-2421935_19721151980.0RegionNote=C-terminal
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-242661_6831151980.0RegionActin-binding
HgeneMYH11chr16:15931765chr22:39482284ENST00000396324-242762_7761151980.0RegionActin-binding
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-2431935_19721152132.0RegionNote=C-terminal
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-243661_6831152132.0RegionActin-binding
HgeneMYH11chr16:15931765chr22:39482284ENST00000452625-243762_7761152132.0RegionActin-binding
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-2421935_19721151912.6666666666667RegionNote=C-terminal
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-242661_6831151912.6666666666667RegionActin-binding
HgeneMYH11chr16:15931765chr22:39482284ENST00000576790-242762_7761151912.6666666666667RegionActin-binding
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000040799748214_328245385.0DomainCMP/dCMP-type deaminase 2
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST000004079974829_138245385.0DomainCMP/dCMP-type deaminase 1
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000045295748214_328245385.0DomainCMP/dCMP-type deaminase 2
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST000004529574829_138245385.0DomainCMP/dCMP-type deaminase 1
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST00000407997481_60245385.0RegionNote=Essential for cytoplasmic localization
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000040799748209_336245385.0RegionNote=Necessary for homooligomerization
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST00000452957481_60245385.0RegionNote=Essential for cytoplasmic localization
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000045295748209_336245385.0RegionNote=Necessary for homooligomerization


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Fusion Gene Sequence for MYH11-APOBEC3G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56283_56283_1_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000452625_APOBEC3G_chr22_39482284_ENST00000407997_length(transcript)=1175nt_BP=433nt
GCCTGGGAGGTGCGTCAGATCCGAGCTCGCCATCCAGTTTCCTCTCCACTAGTCCCCCCAGTTGGAGATCTGGGACCAACAAGGCACCAT
GGCGCAGAAGGGCCAACTCAGTGACGATGAGAAGTTCCTCTTTGTGGACAAAAACTTCATCAACAGCCCAGTGGCCCAGGCTGACTGGGC
CGCCAAGAGACTCGTCTGGGTCCCCTCGGAGAAGCAGGGCTTCGAGGCAGCCAGCATTAAGGAGGAGAAGGGGGATGAGGTGGTTGTGGA
GCTGGTGGAGAATGGCAAGAAGGTCACGGTTGGGAAAGATGACATCCAGAAGATGAACCCACCCAAGTTCTCCAAGGTGGAGGACATGGC
GGAGCTGACGTGCCTCAACGAAGCCTCCGTGCTACACAACCTGAGGGAGCGGTACTTCTCAGGGCTAATATATGCTCCACATAAACACGG
TTTCCTTGAAGGCCGCCATGCAGAGCTGTGCTTCCTGGACGTGATTCCCTTTTGGAAGCTGGACCTGGACCAGGACTACAGGGTTACCTG
CTTCACCTCCTGGAGCCCCTGCTTCAGCTGTGCCCAGGAAATGGCTAAATTCATTTCAAAAAACAAACACGTGAGCCTGTGCATCTTCAC
TGCCCGCATCTATGATGATCAAGGAAGATGTCAGGAGGGGCTGCGCACCCTGGCCGAGGCTGGGGCCAAAATTTCAATAATGACATACAG
TGAATTTAAGCACTGCTGGGACACCTTTGTGGACCACCAGGGATGTCCCTTCCAGCCCTGGGATGGACTAGATGAGCACAGCCAAGACCT
GAGTGGGAGGCTGCGGGCCATTCTCCAGAATCAGGAAAACTGAAGGATGGGCCTCAGTCTCTAAGGAAGGCAGAGACCTGGGTTGAGCCT
CAGAATAAAAGATCTTCTTCCAAGAAATGCAAACAGGCTGTTCACCACCATCTCCAGCTGATCACAGACACCAGCAAAGCAATGCACTCC
TGACCAAGTAGATTCTTTTAAAAATTAGAGTGCATTACTTTGAATCAAAAATTTATTTATATTTCAAGAATAAAGTACTAAGATTGTGCT
CAATACACAGAAAAGTTTCAAACCTACTAATCCAGCGACAATTTGAATCGGTTTTGTAGGTAGAGGAATAAAATGAAATACTAAATCTTT

>56283_56283_1_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000452625_APOBEC3G_chr22_39482284_ENST00000407997_length(amino acids)=263AA_BP=124
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISK

--------------------------------------------------------------
>56283_56283_2_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000452625_APOBEC3G_chr22_39482284_ENST00000452957_length(transcript)=1162nt_BP=433nt
GCCTGGGAGGTGCGTCAGATCCGAGCTCGCCATCCAGTTTCCTCTCCACTAGTCCCCCCAGTTGGAGATCTGGGACCAACAAGGCACCAT
GGCGCAGAAGGGCCAACTCAGTGACGATGAGAAGTTCCTCTTTGTGGACAAAAACTTCATCAACAGCCCAGTGGCCCAGGCTGACTGGGC
CGCCAAGAGACTCGTCTGGGTCCCCTCGGAGAAGCAGGGCTTCGAGGCAGCCAGCATTAAGGAGGAGAAGGGGGATGAGGTGGTTGTGGA
GCTGGTGGAGAATGGCAAGAAGGTCACGGTTGGGAAAGATGACATCCAGAAGATGAACCCACCCAAGTTCTCCAAGGTGGAGGACATGGC
GGAGCTGACGTGCCTCAACGAAGCCTCCGTGCTACACAACCTGAGGGAGCGGTACTTCTCAGGGCTAATATATGCTCCACATAAACACGG
TTTCCTTGAAGGCCGCCATGCAGAGCTGTGCTTCCTGGACGTGATTCCCTTTTGGAAGCTGGACCTGGACCAGGACTACAGGGTTACCTG
CTTCACCTCCTGGAGCCCCTGCTTCAGCTGTGCCCAGGAAATGGCTAAATTCATTTCAAAAAACAAACACGTGAGCCTGTGCATCTTCAC
TGCCCGCATCTATGATGATCAAGGAAGATGTCAGGAGGGGCTGCGCACCCTGGCCGAGGCTGGGGCCAAAATTTCAATAATGACATACAG
TGAATTTAAGCACTGCTGGGACACCTTTGTGGACCACCAGGGATGTCCCTTCCAGCCCTGGGATGGACTAGATGAGCACAGCCAAGACCT
GAGTGGGAGGCTGCGGGCCATTCTCCAGAATCAGGAAAACTGAAGGATGGGCCTCAGTCTCTAAGGAAGGCAGAGACCTGGGTTGAGCCT
CAGAATAAAAGATCTTCTTCCAAGAAATGCAAACAGGCTGTTCACCACCATCTCCAGCTGATCACAGACACCAGCAAAGCAATGCACTCC
TGACCAAGTAGATTCTTTTAAAAATTAGAGTGCATTACTTTGAATCAAAAATTTATTTATATTTCAAGAATAAAGTACTAAGATTGTGCT

>56283_56283_2_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000452625_APOBEC3G_chr22_39482284_ENST00000452957_length(amino acids)=263AA_BP=124
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISK

--------------------------------------------------------------
>56283_56283_3_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000576790_APOBEC3G_chr22_39482284_ENST00000407997_length(transcript)=1197nt_BP=455nt
GCAGGGAGATTTGGACGCTCCGGCCTGGGAGGTGCGTCAGATCCGAGCTCGCCATCCAGTTTCCTCTCCACTAGTCCCCCCAGTTGGAGA
TCTGGGACCAACAAGGCACCATGGCGCAGAAGGGCCAACTCAGTGACGATGAGAAGTTCCTCTTTGTGGACAAAAACTTCATCAACAGCC
CAGTGGCCCAGGCTGACTGGGCCGCCAAGAGACTCGTCTGGGTCCCCTCGGAGAAGCAGGGCTTCGAGGCAGCCAGCATTAAGGAGGAGA
AGGGGGATGAGGTGGTTGTGGAGCTGGTGGAGAATGGCAAGAAGGTCACGGTTGGGAAAGATGACATCCAGAAGATGAACCCACCCAAGT
TCTCCAAGGTGGAGGACATGGCGGAGCTGACGTGCCTCAACGAAGCCTCCGTGCTACACAACCTGAGGGAGCGGTACTTCTCAGGGCTAA
TATATGCTCCACATAAACACGGTTTCCTTGAAGGCCGCCATGCAGAGCTGTGCTTCCTGGACGTGATTCCCTTTTGGAAGCTGGACCTGG
ACCAGGACTACAGGGTTACCTGCTTCACCTCCTGGAGCCCCTGCTTCAGCTGTGCCCAGGAAATGGCTAAATTCATTTCAAAAAACAAAC
ACGTGAGCCTGTGCATCTTCACTGCCCGCATCTATGATGATCAAGGAAGATGTCAGGAGGGGCTGCGCACCCTGGCCGAGGCTGGGGCCA
AAATTTCAATAATGACATACAGTGAATTTAAGCACTGCTGGGACACCTTTGTGGACCACCAGGGATGTCCCTTCCAGCCCTGGGATGGAC
TAGATGAGCACAGCCAAGACCTGAGTGGGAGGCTGCGGGCCATTCTCCAGAATCAGGAAAACTGAAGGATGGGCCTCAGTCTCTAAGGAA
GGCAGAGACCTGGGTTGAGCCTCAGAATAAAAGATCTTCTTCCAAGAAATGCAAACAGGCTGTTCACCACCATCTCCAGCTGATCACAGA
CACCAGCAAAGCAATGCACTCCTGACCAAGTAGATTCTTTTAAAAATTAGAGTGCATTACTTTGAATCAAAAATTTATTTATATTTCAAG
AATAAAGTACTAAGATTGTGCTCAATACACAGAAAAGTTTCAAACCTACTAATCCAGCGACAATTTGAATCGGTTTTGTAGGTAGAGGAA

>56283_56283_3_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000576790_APOBEC3G_chr22_39482284_ENST00000407997_length(amino acids)=263AA_BP=124
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISK

--------------------------------------------------------------
>56283_56283_4_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000576790_APOBEC3G_chr22_39482284_ENST00000452957_length(transcript)=1184nt_BP=455nt
GCAGGGAGATTTGGACGCTCCGGCCTGGGAGGTGCGTCAGATCCGAGCTCGCCATCCAGTTTCCTCTCCACTAGTCCCCCCAGTTGGAGA
TCTGGGACCAACAAGGCACCATGGCGCAGAAGGGCCAACTCAGTGACGATGAGAAGTTCCTCTTTGTGGACAAAAACTTCATCAACAGCC
CAGTGGCCCAGGCTGACTGGGCCGCCAAGAGACTCGTCTGGGTCCCCTCGGAGAAGCAGGGCTTCGAGGCAGCCAGCATTAAGGAGGAGA
AGGGGGATGAGGTGGTTGTGGAGCTGGTGGAGAATGGCAAGAAGGTCACGGTTGGGAAAGATGACATCCAGAAGATGAACCCACCCAAGT
TCTCCAAGGTGGAGGACATGGCGGAGCTGACGTGCCTCAACGAAGCCTCCGTGCTACACAACCTGAGGGAGCGGTACTTCTCAGGGCTAA
TATATGCTCCACATAAACACGGTTTCCTTGAAGGCCGCCATGCAGAGCTGTGCTTCCTGGACGTGATTCCCTTTTGGAAGCTGGACCTGG
ACCAGGACTACAGGGTTACCTGCTTCACCTCCTGGAGCCCCTGCTTCAGCTGTGCCCAGGAAATGGCTAAATTCATTTCAAAAAACAAAC
ACGTGAGCCTGTGCATCTTCACTGCCCGCATCTATGATGATCAAGGAAGATGTCAGGAGGGGCTGCGCACCCTGGCCGAGGCTGGGGCCA
AAATTTCAATAATGACATACAGTGAATTTAAGCACTGCTGGGACACCTTTGTGGACCACCAGGGATGTCCCTTCCAGCCCTGGGATGGAC
TAGATGAGCACAGCCAAGACCTGAGTGGGAGGCTGCGGGCCATTCTCCAGAATCAGGAAAACTGAAGGATGGGCCTCAGTCTCTAAGGAA
GGCAGAGACCTGGGTTGAGCCTCAGAATAAAAGATCTTCTTCCAAGAAATGCAAACAGGCTGTTCACCACCATCTCCAGCTGATCACAGA
CACCAGCAAAGCAATGCACTCCTGACCAAGTAGATTCTTTTAAAAATTAGAGTGCATTACTTTGAATCAAAAATTTATTTATATTTCAAG
AATAAAGTACTAAGATTGTGCTCAATACACAGAAAAGTTTCAAACCTACTAATCCAGCGACAATTTGAATCGGTTTTGTAGGTAGAGGAA

>56283_56283_4_MYH11-APOBEC3G_MYH11_chr16_15931765_ENST00000576790_APOBEC3G_chr22_39482284_ENST00000452957_length(amino acids)=263AA_BP=124
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISK

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Fusion Gene PPI Analysis for MYH11-APOBEC3G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000040799748313_320245.0385.0DNA
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000045295748313_320245.0385.0DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000040799748213_215245.0385.0DNA
TgeneAPOBEC3Gchr16:15931765chr22:39482284ENST0000045295748213_215245.0385.0DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYH11-APOBEC3G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYH11-APOBEC3G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource