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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MYH14-CD164 (FusionGDB2 ID:56318)

Fusion Gene Summary for MYH14-CD164

Fusion gene summary

Fusion gene information	Fusion gene name: MYH14-CD164
	Fusion gene ID: 56318
		Hgene	Tgene
	Gene symbol	MYH14	CD164
	Gene ID	79784	8763
	Gene name	myosin heavy chain 14	CD164 molecule
	Synonyms	DFNA4\|DFNA4A\|FP17425\|MHC16\|MYH17\|NMHC II-C\|NMHC-II-C\|PNMHH\|myosin	DFNA66\|MGC-24\|MGC-24v\|MUC-24\|endolyn
	Cytomap	19q13.33	6q21
	Type of gene	protein-coding	protein-coding
	Description	myosin-14MYH14 variant proteinmyosin heavy chain, non-muscle IIcmyosin, heavy chain 14, non-musclemyosin, heavy polypeptide 14non-muscle myosin heavy chain IIcnonmuscle myosin heavy chain II-C	sialomucin core protein 24CD164 antigen, sialomucinmulti-glycosylated core protein 24
	Modification date	20200313	20200313
	UniProtAcc	Q7Z406	Q04900
	Ensembl transtripts involved in fusion gene	ENST00000262269, ENST00000376970, ENST00000425460, ENST00000440075, ENST00000596571, ENST00000598205, ENST00000601313,	ENST00000275080, ENST00000310786, ENST00000324953, ENST00000368961, ENST00000413644, ENST00000504373, ENST00000506649, ENST00000512821,
Fusion gene scores	* DoF score	30 X 20 X 6=3600	8 X 8 X 1=64
	# samples	31	8
	** MAII score	log2(31/3600*10)=-3.5376567859428 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/64*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MYH14 [Title/Abstract] AND CD164 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MYH14(50782069)-CD164(109687717), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MYH14	GO:0031032	actomyosin structure organization	24072716
Tgene	CD164	GO:0007155	cell adhesion	10491205
Tgene	CD164	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	10491205

Fusion gene breakpoints across MYH14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CD164 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB049054	MYH14	chr19	50782069	-	CD164	chr6	109687717	+

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Fusion Gene ORF analysis for MYH14-CD164

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000262269	ENST00000275080	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000262269	ENST00000310786	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000262269	ENST00000324953	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000262269	ENST00000368961	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000262269	ENST00000413644	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000262269	ENST00000504373	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000262269	ENST00000506649	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000262269	ENST00000512821	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000275080	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000310786	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000324953	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000368961	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000413644	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000504373	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000506649	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000376970	ENST00000512821	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000275080	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000310786	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000324953	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000368961	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000413644	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000504373	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000506649	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000425460	ENST00000512821	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000275080	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000310786	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000324953	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000368961	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000413644	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000504373	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000506649	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000440075	ENST00000512821	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000275080	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000310786	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000324953	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000368961	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000413644	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000504373	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000506649	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000596571	ENST00000512821	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000275080	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000310786	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000324953	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000368961	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000413644	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000504373	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000506649	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000598205	ENST00000512821	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000275080	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000310786	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000324953	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000368961	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000413644	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000504373	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000506649	MYH14	chr19	50782069	-	CD164	chr6	109687717	+
intron-intron	ENST00000601313	ENST00000512821	MYH14	chr19	50782069	-	CD164	chr6	109687717	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MYH14-CD164

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYH14-CD164

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50782069/:109687717)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYH14 Q7Z406	CD164 Q04900
FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.	FUNCTION: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). {ECO:0000250\|UniProtKB:Q9R0L9, ECO:0000269\|PubMed:16859559, ECO:0000269\|PubMed:17077324, ECO:0000269\|PubMed:9763543}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MYH14-CD164

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYH14-CD164

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MYH14-CD164

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MYH14-CD164

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source