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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:APOO-CNKSR2 (FusionGDB2 ID:5632) |
Fusion Gene Summary for APOO-CNKSR2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APOO-CNKSR2 | Fusion gene ID: 5632 | Hgene | Tgene | Gene symbol | APOO | CNKSR2 | Gene ID | 79135 | 22866 |
| Gene name | apolipoprotein O | connector enhancer of kinase suppressor of Ras 2 | |
| Synonyms | FAM121B|MIC26|MICOS26|Mic23|My025 | CNK2|KSR2|MAGUIN|MRXSHG | |
| Cytomap | Xp22.11 | Xp22.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MICOS complex subunit MIC26MICOS complex subunit MIC23brain my025family with sequence similarity 121Bmitochondrial contact site and cristae organizing system subunit 26 | connector enhancer of kinase suppressor of ras 2CNK homolog protein 2connector enhancer of KSR2membrane-associated guanylate kinase-interacting protein | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q9BUR5 | Q8WXI2 | |
| Ensembl transtripts involved in fusion gene | ENST00000379220, ENST00000379226, ENST00000476598, | ENST00000485012, ENST00000279451, ENST00000379510, ENST00000425654, ENST00000543067, | |
| Fusion gene scores | * DoF score | 9 X 10 X 4=360 | 6 X 9 X 4=216 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: APOO [Title/Abstract] AND CNKSR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | APOO(23897032)-CNKSR2(21488884), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CNKSR2 | GO:0035556 | intracellular signal transduction | 14597674 |
| Fusion gene breakpoints across APOO (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CNKSR2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-66-2790-01A | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| ChimerDB4 | LUSC | TCGA-66-2790 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
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Fusion Gene ORF analysis for APOO-CNKSR2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000379220 | ENST00000485012 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| 5CDS-intron | ENST00000379226 | ENST00000485012 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379220 | ENST00000279451 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379220 | ENST00000379510 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379220 | ENST00000425654 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379220 | ENST00000543067 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379226 | ENST00000279451 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379226 | ENST00000379510 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379226 | ENST00000425654 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| In-frame | ENST00000379226 | ENST00000543067 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| intron-3CDS | ENST00000476598 | ENST00000279451 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| intron-3CDS | ENST00000476598 | ENST00000379510 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| intron-3CDS | ENST00000476598 | ENST00000425654 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| intron-3CDS | ENST00000476598 | ENST00000543067 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| intron-intron | ENST00000476598 | ENST00000485012 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000543067 | CNKSR2 | chrX | 21488884 | + | 3825 | 469 | 232 | 2499 | 755 |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000425654 | CNKSR2 | chrX | 21488884 | + | 5138 | 469 | 232 | 2964 | 910 |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000279451 | CNKSR2 | chrX | 21488884 | + | 3972 | 469 | 232 | 2646 | 804 |
| ENST00000379226 | APOO | chrX | 23897032 | - | ENST00000379510 | CNKSR2 | chrX | 21488884 | + | 5229 | 469 | 232 | 3054 | 940 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000543067 | CNKSR2 | chrX | 21488884 | + | 3831 | 475 | 238 | 2505 | 755 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000425654 | CNKSR2 | chrX | 21488884 | + | 5144 | 475 | 238 | 2970 | 910 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000279451 | CNKSR2 | chrX | 21488884 | + | 3978 | 475 | 238 | 2652 | 804 |
| ENST00000379220 | APOO | chrX | 23897032 | - | ENST00000379510 | CNKSR2 | chrX | 21488884 | + | 5235 | 475 | 238 | 3060 | 940 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000379226 | ENST00000543067 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000421735 | 0.9995783 |
| ENST00000379226 | ENST00000425654 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.00011226 | 0.9998877 |
| ENST00000379226 | ENST00000279451 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000349089 | 0.99965096 |
| ENST00000379226 | ENST00000379510 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000134512 | 0.9998654 |
| ENST00000379220 | ENST00000543067 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000423335 | 0.9995766 |
| ENST00000379220 | ENST00000425654 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.000112491 | 0.99988747 |
| ENST00000379220 | ENST00000279451 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.00034998 | 0.99965 |
| ENST00000379220 | ENST00000379510 | APOO | chrX | 23897032 | - | CNKSR2 | chrX | 21488884 | + | 0.00013488 | 0.99986506 |
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Fusion Genomic Features for APOO-CNKSR2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| APOO | chrX | 23897031 | - | CNKSR2 | chrX | 21488883 | + | 0.000108903 | 0.99989104 |
| APOO | chrX | 23897031 | - | CNKSR2 | chrX | 21488883 | + | 0.000108903 | 0.99989104 |
| APOO | chrX | 23897031 | - | CNKSR2 | chrX | 21488883 | + | 0.000108903 | 0.99989104 |
| APOO | chrX | 23897031 | - | CNKSR2 | chrX | 21488883 | + | 0.000108903 | 0.99989104 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for APOO-CNKSR2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:23897032/chrX:21488884) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APOO | CNKSR2 |
| FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:24743151, ECO:0000269|PubMed:25764979}. | FUNCTION: May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 875_904 | 173 | 899.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 875_904 | 173 | 1035.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 875_904 | 173 | 1005.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 875_904 | 173 | 850.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 354_357 | 173 | 899.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 703_706 | 173 | 899.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 875_888 | 173 | 899.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 354_357 | 173 | 1035.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 703_706 | 173 | 1035.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 875_888 | 173 | 1035.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 354_357 | 173 | 1005.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 703_706 | 173 | 1005.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 875_888 | 173 | 1005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 354_357 | 173 | 850.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 703_706 | 173 | 850.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 875_888 | 173 | 850.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 215_297 | 173 | 899.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 332_515 | 173 | 899.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 570_669 | 173 | 899.0 | Domain | PH | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 215_297 | 173 | 1035.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 332_515 | 173 | 1035.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 570_669 | 173 | 1035.0 | Domain | PH | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 215_297 | 173 | 1005.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 332_515 | 173 | 1005.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 570_669 | 173 | 1005.0 | Domain | PH | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 215_297 | 173 | 850.0 | Domain | PDZ | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 332_515 | 173 | 850.0 | Domain | Note=DUF1170 | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 570_669 | 173 | 850.0 | Domain | PH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APOO | chrX:23897032 | chrX:21488884 | ENST00000379226 | - | 3 | 9 | 108_128 | 79 | 191.0 | Transmembrane | Helical |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 11_76 | 173 | 899.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000279451 | 3 | 21 | 84_178 | 173 | 899.0 | Domain | CRIC | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 11_76 | 173 | 1035.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000379510 | 3 | 22 | 84_178 | 173 | 1035.0 | Domain | CRIC | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 11_76 | 173 | 1005.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000425654 | 3 | 21 | 84_178 | 173 | 1005.0 | Domain | CRIC | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 11_76 | 173 | 850.0 | Domain | SAM | |
| Tgene | CNKSR2 | chrX:23897032 | chrX:21488884 | ENST00000543067 | 3 | 20 | 84_178 | 173 | 850.0 | Domain | CRIC |
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Fusion Gene Sequence for APOO-CNKSR2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5632_5632_1_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000279451_length(transcript)=3978nt_BP=475nt GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGA CCCGAGTGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCC CCTTGCTCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAG TTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCT CAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATAT TGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGG CAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGA AAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAA GTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCAT GGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTAT AGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAG TTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGA AGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAA AAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGA GAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACC CCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGAC TTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCG CCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTC TGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCC CTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCA TTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGA GGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGTTGGTAGAACCTCTCCATGCCAAATCGGATCCAC TTCTGTTGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAATTTAGATCGGAGAGAGTCGGTACGGCGCAGACTC AACATCAACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAAAACAGACTTGTAAAAAGCTTAGATCATCAAGTG TTTTGGATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGAATGCGAGCTTTCTACATTGGGACTAGCATAAGA TCAAAGCCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAACAGAAGGGGAAAGGGTCTTAACTGGGAAAGGGCT CTGTGTGGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGCTTCAATAACTAGAAAATTCTGGCTGTTTAATGG ACTCTTTGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTATTTTGCATTTTTAAAACTTGACGTGCTGTATTG TACTAAATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTACTATGTTTATTCTATTATAAAGTGTATTCAGGT GCAACACAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTTTATTATAGAATCTTCAGCTAAAATCCTAACTTT CTCCTTATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAGCTATTCTTTTCTGTAAAATATTTTGAATCTATA GGCTGTGGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTCAGATATTATTTAATACTATGTAACTGGGTCCCC TATGGCTCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTAGTTGGATAAGATACACTGTAATAATTTTAATGC TAATTAATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAAATGTTTTTTTCTTCCTGTCACCGCAGTGTGTGG TATTGCATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGACCAATTGGTATCAGATCTTTTCAGATAGCTAAAT AATTTGCTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTTCTTTCTCACAAATGGAATTTGTGTCTGTGAATA >5632_5632_1_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000279451_length(amino acids)=804AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK -------------------------------------------------------------- >5632_5632_2_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000379510_length(transcript)=5235nt_BP=475nt GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGA CCCGAGTGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCC CCTTGCTCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAG TTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCT CAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATAT TGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGG CAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGA AAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAA GTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCAT GGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTAT AGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAG TTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGA AGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAA AAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGA GAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACC CCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGAC TTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCG CCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTC TGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCC CTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCA TTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGA GGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGC ACTGGAGCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGA TCCTGTAATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGT CCTAGACAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCAC CTCAAATGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTA AATGTATTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGA CAAGCTATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTAT ATGCAACAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACA GGTGGTCTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACT TCAAAAGTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAG AATTTTCTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGA GCATCGACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAA ATCTATGAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTT CTTGGTTTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAA CACACCCAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAA GGTATAAACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGG GAAGTACAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCA GGTGATGGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAG TGGATGAAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTG CTGCTTTTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATA TCCTAAAATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAG TGAATATTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTT TTGCAGACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCA TGTATTAATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCA TGGATATTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAA GTGTGCTTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTG TCATGTTTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTT GTAAAGTCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTT AACACTATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCT >5632_5632_2_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000379510_length(amino acids)=940AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK CHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEK LGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYL -------------------------------------------------------------- >5632_5632_3_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000425654_length(transcript)=5144nt_BP=475nt GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGA CCCGAGTGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCC CCTTGCTCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAG TTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCT CAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATAT TGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGA AAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAA GTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCAT GGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTAT AGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAG TTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGA AGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAA AAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGA GAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACC CCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGAC TTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCG CCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTC TGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCC CTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCA TTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGA GGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGC ACTGGAGCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGA TCCTGTAATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGT CCTAGACAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCAC CTCAAATGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTA AATGTATTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGA CAAGCTATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTAT ATGCAACAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACA GGTGGTCTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACT TCAAAAGTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAG AATTTTCTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGA GCATCGACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAA ATCTATGAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTT CTTGGTTTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAA CACACCCAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAA GGTATAAACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGG GAAGTACAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCA GGTGATGGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAG TGGATGAAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTG CTGCTTTTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATA TCCTAAAATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAG TGAATATTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTT TTGCAGACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCA TGTATTAATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCA TGGATATTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAA GTGTGCTTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTG TCATGTTTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTT GTAAAGTCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTT AACACTATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCT >5632_5632_3_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000425654_length(amino acids)=910AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYENSLLRYMSNEKIAQEEYMF QRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCE GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI NMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSA VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRS FTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKME YKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLA -------------------------------------------------------------- >5632_5632_4_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000543067_length(transcript)=3831nt_BP=475nt GGGTTTGCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCG CACCGAGTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCT CTATAGTGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCC AGCCAGCCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTC ACTCTACTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTG CGAGCCATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTG TGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGA AGGGCTGGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAA AATCCATGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTC CAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAG GGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATT TCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAG TCAAGGAAGACGAGAAAGCACCCCAACTTATGGCAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGA TCCAAATAAGATGAAGAGAGATAGTAGAAGAGAAAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTT TCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAG TTTACAAATGGATGCACTGAGACAAGACATCATGGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCA GCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGA GGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTA TTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAA ATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAAT TAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATAC TCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGA AGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGC AGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCT TCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAA ATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAG TTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCC AGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGT TGGTAGAACCTCTCCATGCCAAATCGGATCCACTTCTGTTGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAAT TTAGATCGGAGAGAGTCGGTACGGCGCAGACTCAACATCAACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAA AACAGACTTGTAAAAAGCTTAGATCATCAAGTGTTTTGGATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGA ATGCGAGCTTTCTACATTGGGACTAGCATAAGATCAAAGCCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAAC AGAAGGGGAAAGGGTCTTAACTGGGAAAGGGCTCTGTGTGGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGC TTCAATAACTAGAAAATTCTGGCTGTTTAATGGACTCTTTGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTA TTTTGCATTTTTAAAACTTGACGTGCTGTATTGTACTAAATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTA CTATGTTTATTCTATTATAAAGTGTATTCAGGTGCAACACAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTT TATTATAGAATCTTCAGCTAAAATCCTAACTTTCTCCTTATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAG CTATTCTTTTCTGTAAAATATTTTGAATCTATAGGCTGTGGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTC AGATATTATTTAATACTATGTAACTGGGTCCCCTATGGCTCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTA GTTGGATAAGATACACTGTAATAATTTTAATGCTAATTAATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAA ATGTTTTTTTCTTCCTGTCACCGCAGTGTGTGGTATTGCATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGAC CAATTGGTATCAGATCTTTTCAGATAGCTAAATAATTTGCTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTT >5632_5632_4_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379220_CNKSR2_chrX_21488884_ENST00000543067_length(amino acids)=755AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIP RSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLY CYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKS NSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKK YWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDY WSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIE TPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVS -------------------------------------------------------------- >5632_5632_5_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000279451_length(transcript)=3972nt_BP=469nt GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGACCCGAG TGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCCCCTTGC TCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGC CCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGG ACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGA AGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGGCAAGCT ACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGAAAACTC TCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAA AAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCATGGGCAC TCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGG CAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTT TTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATT CATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTT TTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGAT TAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATA TGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCA GTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTC CTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTC CGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGC TGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTG TCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGG GGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGTTGGTAGAACCTCTCCATGCCAAATCGGATCCACTTCTGT TGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAATTTAGATCGGAGAGAGTCGGTACGGCGCAGACTCAACATC AACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAAAACAGACTTGTAAAAAGCTTAGATCATCAAGTGTTTTGG ATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGAATGCGAGCTTTCTACATTGGGACTAGCATAAGATCAAAG CCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAACAGAAGGGGAAAGGGTCTTAACTGGGAAAGGGCTCTGTGT GGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGCTTCAATAACTAGAAAATTCTGGCTGTTTAATGGACTCTT TGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTATTTTGCATTTTTAAAACTTGACGTGCTGTATTGTACTAA ATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTACTATGTTTATTCTATTATAAAGTGTATTCAGGTGCAACA CAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTTTATTATAGAATCTTCAGCTAAAATCCTAACTTTCTCCTT ATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAGCTATTCTTTTCTGTAAAATATTTTGAATCTATAGGCTGT GGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTCAGATATTATTTAATACTATGTAACTGGGTCCCCTATGGC TCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTAGTTGGATAAGATACACTGTAATAATTTTAATGCTAATTA ATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAAATGTTTTTTTCTTCCTGTCACCGCAGTGTGTGGTATTGC ATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGACCAATTGGTATCAGATCTTTTCAGATAGCTAAATAATTTG CTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTTCTTTCTCACAAATGGAATTTGTGTCTGTGAATAAAATCA >5632_5632_5_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000279451_length(amino acids)=804AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK -------------------------------------------------------------- >5632_5632_6_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000379510_length(transcript)=5229nt_BP=469nt GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGACCCGAG TGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCCCCTTGC TCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGC CCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGG ACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGA AGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGGCAAGCT ACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGAAAACTC TCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAA AAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCATGGGCAC TCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGG CAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTT TTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATT CATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTT TTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGAT TAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATA TGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCA GTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTC CTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTC CGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGC TGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTG TCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGG GGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGCACTGGA GCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGATCCTGT AATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGTCCTAGA CAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCACCTCAAA TGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTAAATGTA TTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGACAAGCT ATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTATATGCAA CAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACAGGTGGT CTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACTTCAAAA GTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAGAATTTT CTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGAGCATCG ACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAAATCTAT GAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTTCTTGGT TTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAACACACC CAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAAGGTATA AACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGGGAAGTA CAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCAGGTGAT GGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAGTGGATG AAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTGCTGCTT TTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATATCCTAA AATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAGTGAATA TTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTTTTGCAG ACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCATGTATT AATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCATGGATA TTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAAGTGTGC TTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTGTCATGT TTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTTGTAAAG TCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTTAACACT ATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCTCTTAAT >5632_5632_6_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000379510_length(amino acids)=940AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYED PNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQ HKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKK YAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVE AKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQK CHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEK LGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYL -------------------------------------------------------------- >5632_5632_7_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000425654_length(transcript)=5138nt_BP=469nt GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAATGCACTACGAGAGGACCCGAG TGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAGCACCAGCTTTACTGAAAAATATGAGATGGAAGCCCCTTGC TCTGCAGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGC CCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAGACCTCAGAGG ACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCAGGAATATCGAAAGAGATTTAATATTGTCGA AGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGAAAACTC TCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAGGACACAGGGAAGAAGTCAAA AAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACAAATGGATGCACTGAGACAAGACATCATGGGCAC TCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGG CAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGAAGAGTTACTT TTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATATTAATGAGGAGGATGAAAAAGCAGAAGGATT CATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTT TTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGAT TAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAAGATAGCCCTCCACCCCCATA TGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCA GTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTC CTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCTTCTCTGACTC CGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCTGCAGGATCACTATGGGCCATACCCCTTAGC TGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTG TCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGG GGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAAGATTTATACAGGGCACTGGA GCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGGAATACAAGCTATCATTTATAAAAAGATGTAATGATCCTGT AATGAATGAAAAACTACACCGGCTGAGAATTCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGTCCTAGA CAATCCAGACTTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATACCACCTCAAA TGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCATTCATACATTGAAACGCATGTCTAAATGTA TTCTGCCTTCAGACCATCTAGTACCTGCTGGTACTCTGAACAAGTATATAAGGTAGTTTTTATATCAATGTGTGGAACACTTGACAAGCT ATACTTTAATGTTACCAAACTATATGAAACAAACCATATATGGTCACAATACCACTATCTTTAATGAGCATTTGTATATTTTATATGCAA CAGTGCTCAGCTTATGTTTACCATGTGCAAAATCAACTGTCTTTAATGACTTAAAATTAACTTTTGCAAACAATTCTAAATACAGGTGGT CTTCAAGTAGTAAAACCACAAAAGGCAGTTTTCTATCTATGGTCATCTTTTCTCCCTTTAAGTTAATTTTATATAAACAAGACTTCAAAA GTAAATCACATTTTTTCAGGTGCAGACATCCTTGTGGGTGGGAAAGAATTTAAACCTTTTTTATATTTATTAAAATGTTCTAAGAATTTT CTTAAACATTGCACAAAGTTTAATGCTGTAGTTTTATTTTTGTGAAATGTAGATGCGCATACAAGAGCTAAGCAAAATAGAAGAGCATCG ACATAAGAAAAGTTCAGGTATCTAATATTCGTCTTAATAGTCTATTAACTTGTGAAAGCTAAGTTAATGGAAATATTATTCCAAATCTAT GAGAACACTTGGTGTATCAGGGCAAAGCTTTGTAAGATGTTTTTGTAACTAAGACCAAAATTGAAGATAGAGCTGCTTTATTTTCTTGGT TTAAATCTTCCTTTATTTTTGTAGTGATGAGATGCTGATTGTGTACAGAAGAATTTGAGAGGGGATTTTTAAAAACTGACTTAACACACC CAGAAAGGCAGCTAACAGCTATATATATATATAAATTTCAGCCCAAACTCATGTTTTTAAACTCCAACTCTTAAAAGACAACAAGGTATA AACTGAAATGAATCAACTTTCCACTTAGTTTCCAATTTTCCCCTAGTCCACTAATTAAACTTAGGTAATTATACTTCAGGTAGGGAAGTA CAATATGTTTAGTTTCAGGCTGATGTGTGTTATAAAAAACAACACTGAAAAATAAAAATGTACTTCCCTTCTAAGGAGCAAGCAGGTGAT GGTCATTCAAAGAGATGTCACATTGAATTATGAGAGAAACAATTTAGAGGTTTTTTTCCTGGCTTCATGAATTGTTCTATAGAGTGGATG AAGTCTAAGGAAAAGTCCTCTTCATATATTTCCATTTATAAGCGTCTTGTTTTTGAAAGTGATCACAGCATGAAAATGACTGTGCTGCTT TTTAGTGTCTGGCTGCATAATGTACAAGTCACAATTTGCTGTTTTTTTCAGGAGGAGAAAGGGAACCTCCTTTACTATTCTATATCCTAA AATCTACTTCTAATCAGCTTTATACTGTTGCCTGTACAGCTCAGTGAATGTACTTTCATCTTTAAGAGTTCAGATATATGCCAGTGAATA TTTTTGCTGTAGAGGAGAAAGTAAAAACTCCACAGCGGGGATCTTTTTCTTTGCTTTTGAAACCACCATTGAATCACTATCGTTTTGCAG ACTTTGCACAACTGTACAGGAGAGTGGCCTTTCTACAGCACATTTTCAGTAATCCTATATTTAGTCAAAATGGATGAGAAATCATGTATT AATGTTTGTATGGAATTTTGGGTCCAGTGTAATATTTTTATCATTTAAAAAGAACTCTATTTGTAAAAACATTTATTTACTGCATGGATA TTGACGCACATTAAATTTGTGGGATTTTGTATATGTAAAAAAAAAAAAAAAAAAAAAACAAAAAACCTCTTGTCCTAAAATGAAGTGTGC TTGTTAACAGGTGTTTAGACTTATTGATGTTTACTAGACCAAATGTGTATGTTCACTTAAAAATATATGTACCTGATGGATGTGTCATGT TTACAGTGGCCAGGTTGTGGCCTGTAAACAGCAAGCAGTTGACGGGAAGACTAGCTCTGTTGCTACTAAGCAGCTTTTACTTTTGTAAAG TCAGCTCTGTTGTTTTAAATGGTAAAAATTAAACTAATGAATTTGACAAGACTCGTGGCTAGCCTAGCATGAAAGAGACCTTTTAACACT ATATAATATCTGTACATTTTATTGCATTCGTTTCAAATCTAGGAGAGAGGCAGCACTGTAAACTGAAGTCAAATAAATTCAGCTCTTAAT >5632_5632_7_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000425654_length(amino acids)=910AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQ LKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPR DEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYENSLLRYMSNEKIAQEEYMF QRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCE GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI NMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSA VSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRS FTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKME YKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLA -------------------------------------------------------------- >5632_5632_8_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000543067_length(transcript)=3825nt_BP=469nt GCGTTCACCCGCTGCCCGGGCGCGACGCGCTGCGGCTCAGCGACGCGGCTTCTAGAACCGGGTGATTGAACTAAACCTTCGCCGCACCGA GTTTGCAGTACGGCCGTCACCCGCACCGCTGCCTGCTTGCGGTTGGAGAAATCAAGGCCCTACCGGGCCTCCGTAGTCACCTCTCTATAG TGGGCGTGGCCGAGGCCGGGGTGACCCTGCCGGAGCCTCCGCTGCCAGCGACATGTTCAAGGTAATTCAGAGGTCCGTGGGGCCAGCCAG CCTGAGCTTGCTCACCTTCAAAGTCTATGCAGCACCAAAAAAGGACTCACCTCCCAAAAATTCCGTGAAGGTTGATGAGCTTTCACTCTA CTCAGTTCCTGAGGGTCAATCGAAGTATGTGGAGGAGGCAAGGAGCCAGCTTGAAGAAAGCATCTCACAGCTCCGACACTATTGCGAGCC ATACACAACCTGGTGTCAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGTGTGTAAAACTCTTTCTGGAGTCTGTGACCA CATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCTGCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCT GGGTATGTATATTAAATCTACATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGCCTCTTATACCTAGAAGTCCCACAAGCAGCGTTGCCACGCCTTCCAGCAC CATCAGTACACCCACCAAAAGAGACAGTTCTGCCCTCCAGGATCTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGA AAAAGGAAACCTTCCTTGTGAAGACCTCAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGA TCAGGAATATCGAAAGAGATTTAATATTGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGAAGATCAAGTAGTCAAGG AAGACGAGAAAGCACCCCAACTTATGGCAAGCTACGACCTATATCTATGCCAGTGGAATATAATTGGGTGGGGGACTATGAAGATCCAAA TAAGATGAAGAGAGATAGTAGAAGAGAAAACTCTCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAG AAACAGCAAAAAGGACACAGGGAAGAAGTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTAGTTTACA AATGGATGCACTGAGACAAGACATCATGGGCACTCCTGTGCCAGAGACCACACTATACCATACATTTCAGCAGTCCTCACTGCAGCACAA ATCAAAGAAGAAAAACAAAGGTCCTATAGCAGGCAAGAGCAAAAGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTG GCTTTGGAAAAAGAAAGATGCGAAGAGTTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTA TATTAATGAGGAGGATGAAAAAGCAGAAGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAATGCCGCAAAAAATATGC ATTCAAAGCCTGTCATCCTAAAATCAAAAGCTTTTATTTTGCTGCTGAACATCTTGATGATATGAACAGGTGGCTTAACAGAATTAATAT GCTGACTGCAGGATATGCAGAAAGAGAGAGGATTAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATC AACACCAAAACAAGATAGCCCTCCACCCCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGGAAGCAAA ACATAGCCGACTTTCCTCCACGGAGACTTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCAGGAAGTAACTGGGAGCAGTGCAGTGTC TCCCATTCGCAAGACAGCCAGTCAGCGCCGCTCCTGGCAGGATTTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGAC TCTGCCCCTGGAGGATTCTGTCTTCTCTGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCA CCTGCAGGATCACTATGGGCCATACCCCTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGCAAGCCTCGAAGTTTTAC TCTGCCTCGAGATAGCGGGTTCAACCATTGCTGTCTGAATGCTCCAGTTAGTGCCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGT GGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGGGGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGCTAATACACTGCGAGAGTTGGTAG AACCTCTCCATGCCAAATCGGATCCACTTCTGTTGGCACTCAACCCATTGGACTCACAGATTGATAAGCTAATGTTTAGAGAATTTAGAT CGGAGAGAGTCGGTACGGCGCAGACTCAACATCAACCTCTTGCAAGCAACTAAAATGGCCTCGTCCTTGCTGTTTATAACAGAAAACAGA CTTGTAAAAAGCTTAGATCATCAAGTGTTTTGGATTGGGGGCCTCCCAAAGGGATATAAGAGGGGCAGGCCACTCTTAAGAAGAATGCGA GCTTTCTACATTGGGACTAGCATAAGATCAAAGCCAATCAAGATGGAGCACAGTAACAGAAAACTGCGGTTTCTGTGGGAGAACAGAAGG GGAAAGGGTCTTAACTGGGAAAGGGCTCTGTGTGGTAACACCTCAGTTGTGTTCTCCTGACACCAGGAAAAGAGAGGGATCAGCTTCAAT AACTAGAAAATTCTGGCTGTTTAATGGACTCTTTGGTGGCCTCTTTAAGGCAAAGCAGAGAAAGCAAATTATGTATTAAGTGTATTTTGC ATTTTTAAAACTTGACGTGCTGTATTGTACTAAATTAAGTGTAATCTATTAAGGCAAGGTATACACAATTTGCTTTGAAACTTACTATGT TTATTCTATTATAAAGTGTATTCAGGTGCAACACAGAGACTGCTTTCGGTGACATTAATGAAGAAAATTTCTCATGCCAGGCTTTATTAT AGAATCTTCAGCTAAAATCCTAACTTTCTCCTTATTTCTTGGCACTTGTATACAAGTGGTGTTGCCTCTTAGGGCAGGCATGAGCTATTC TTTTCTGTAAAATATTTTGAATCTATAGGCTGTGGGTTTCATTTTTGAAAAGTATTTTGTCTGGATGTCTTTCAAACTAGCTTCAGATAT TATTTAATACTATGTAACTGGGTCCCCTATGGCTCAATCAATATTGCTTATTTTTCTTCTGTAGTGGATGTGAAATTTCCTTTAGTTGGA TAAGATACACTGTAATAATTTTAATGCTAATTAATGATATTTCATACTGTGCAATGAACAGATAATTTAACACTGTATTTTGAAATGTTT TTTTCTTCCTGTCACCGCAGTGTGTGGTATTGCATAATGTGAATACCTGTAAAAATATAAATTACTTAAAAATAAAAATATGACCAATTG GTATCAGATCTTTTCAGATAGCTAAATAATTTGCTAAGTATGCCTGATAGTAAATATCTTTCTAAAAAGAAGTAATCAGTGCTTCTTTCT >5632_5632_8_APOO-CNKSR2_APOO_chrX_23897032_ENST00000379226_CNKSR2_chrX_21488884_ENST00000543067_length(amino acids)=755AA_BP=78 MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQDCTVYETENKI LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIP RSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLY CYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKS NSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKK YWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDY WSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIE TPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for APOO-CNKSR2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APOO-CNKSR2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for APOO-CNKSR2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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