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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYH9-EMID1 (FusionGDB2 ID:56378)

Fusion Gene Summary for MYH9-EMID1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYH9-EMID1
Fusion gene ID: 56378
HgeneTgene
Gene symbol

MYH9

EMID1

Gene ID

4627

129080

Gene namemyosin heavy chain 9EMI domain containing 1
SynonymsBDPLT6|DFNA17|EPSTS|FTNS|MATINS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCAEMI5|EMU1
Cytomap

22q12.3

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionmyosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-AEMI domain-containing protein 1emilin and multimerin domain-containing protein 1
Modification date2020031520200313
UniProtAcc.

Q96A84

Ensembl transtripts involved in fusion geneENST00000216181, ENST00000401701, 
ENST00000475726, 		ENST00000484039, 
ENST00000334018, ENST00000404755, 
ENST00000404820, 
Fusion gene scores* DoF score55 X 51 X 22=617109 X 12 X 7=756
# samples 7712
** MAII scorelog2(77/61710*10)=-6.32450203855119
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYH9 [Title/Abstract] AND EMID1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYH9(36744949)-EMID1(29610915), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYH9

GO:0001525

angiogenesis

16403913

HgeneMYH9

GO:0001778

plasma membrane repair

27325790

HgeneMYH9

GO:0006509

membrane protein ectodomain proteolysis

16186248

HgeneMYH9

GO:0030048

actin filament-based movement

12237319|15845534

HgeneMYH9

GO:0031032

actomyosin structure organization

24072716


check buttonFusion gene breakpoints across MYH9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EMID1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-2398-01AMYH9chr22

36744949

-EMID1chr22

29610915

+


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Fusion Gene ORF analysis for MYH9-EMID1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000216181ENST00000484039MYH9chr22

36744949

-EMID1chr22

29610915

+
5CDS-intronENST00000401701ENST00000484039MYH9chr22

36744949

-EMID1chr22

29610915

+
In-frameENST00000216181ENST00000334018MYH9chr22

36744949

-EMID1chr22

29610915

+
In-frameENST00000216181ENST00000404755MYH9chr22

36744949

-EMID1chr22

29610915

+
In-frameENST00000216181ENST00000404820MYH9chr22

36744949

-EMID1chr22

29610915

+
In-frameENST00000401701ENST00000334018MYH9chr22

36744949

-EMID1chr22

29610915

+
In-frameENST00000401701ENST00000404755MYH9chr22

36744949

-EMID1chr22

29610915

+
In-frameENST00000401701ENST00000404820MYH9chr22

36744949

-EMID1chr22

29610915

+
intron-3CDSENST00000475726ENST00000334018MYH9chr22

36744949

-EMID1chr22

29610915

+
intron-3CDSENST00000475726ENST00000404755MYH9chr22

36744949

-EMID1chr22

29610915

+
intron-3CDSENST00000475726ENST00000404820MYH9chr22

36744949

-EMID1chr22

29610915

+
intron-intronENST00000475726ENST00000484039MYH9chr22

36744949

-EMID1chr22

29610915

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216181MYH9chr2236744949-ENST00000334018EMID1chr2229610915+24485646371794385
ENST00000216181MYH9chr2236744949-ENST00000404820EMID1chr2229610915+24545646371800387
ENST00000216181MYH9chr2236744949-ENST00000404755EMID1chr2229610915+23855646371731364
ENST00000401701MYH9chr2236744949-ENST00000334018EMID1chr2229610915+23034194921649385
ENST00000401701MYH9chr2236744949-ENST00000404820EMID1chr2229610915+23094194921655387
ENST00000401701MYH9chr2236744949-ENST00000404755EMID1chr2229610915+22404194921586364

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216181ENST00000334018MYH9chr2236744949-EMID1chr2229610915+0.474895570.52510446
ENST00000216181ENST00000404820MYH9chr2236744949-EMID1chr2229610915+0.474286760.5257132
ENST00000216181ENST00000404755MYH9chr2236744949-EMID1chr2229610915+0.4069030.593097
ENST00000401701ENST00000334018MYH9chr2236744949-EMID1chr2229610915+0.549577360.45042264
ENST00000401701ENST00000404820MYH9chr2236744949-EMID1chr2229610915+0.5585330.441467
ENST00000401701ENST00000404755MYH9chr2236744949-EMID1chr2229610915+0.472659050.52734095

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Fusion Genomic Features for MYH9-EMID1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYH9-EMID1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:36744949/chr22:29610915)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EMID1

Q96A84

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH9chr22:36744949chr22:29610915ENST00000216181-24127_771111961.0DomainMyosin N-terminal SH3-like
TgeneEMID1chr22:36744949chr22:29610915ENST00000334018015179_36833444.0DomainNote=Collagen-like
TgeneEMID1chr22:36744949chr22:29610915ENST0000033401801533_10633444.0DomainEMI

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH9chr22:36744949chr22:29610915ENST00000216181-241837_19261111961.0Coiled coilOntology_term=ECO:0000255
HgeneMYH9chr22:36744949chr22:29610915ENST00000216181-241779_8081111961.0DomainIQ
HgeneMYH9chr22:36744949chr22:29610915ENST00000216181-24181_7761111961.0DomainMyosin motor
HgeneMYH9chr22:36744949chr22:29610915ENST00000216181-241174_1811111961.0Nucleotide bindingATP
HgeneMYH9chr22:36744949chr22:29610915ENST00000216181-241654_6761111961.0RegionNote=Actin-binding


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Fusion Gene Sequence for MYH9-EMID1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56378_56378_1_MYH9-EMID1_MYH9_chr22_36744949_ENST00000216181_EMID1_chr22_29610915_ENST00000334018_length(transcript)=2448nt_BP=564nt
GAGGGCGGGGCGGGAAGGCGGCGAGGAGCCGAGCTGGGTGCGGTGAGGCGCGCAGATCACCGCGGTTCCTGGGCAGGGCACGGAAGGCTA
AGCAAGGCTGACCTGCTGCAGCTCCCGCCTCGTGCGCTCGCCCCACCCGGCCGCCGCCCGAGCGCTCGAGAAAGTCCTCTCGGGAGAAGC
AGCGCCTGTTCCCGGGGCAGATCCAGGTTCAGGTCCTGGCTATAAGTCACCATGGCACAGCAAGCTGCCGATAAGTATCTCTATGTGGAT
AAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAGCTGGTATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCA
GCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAGAATGGGAAGAAGGTGAAGGTGAACAAGGATGACATCCAG
AAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACGTGCCTCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAG
CGTTACTACTCAGGGCTCATCTACGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCATGTGCAGAATGGCACCTACCTTCA
GCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAGACCCACATACAAGGTGATGTACAA
GATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCC
CATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGAC
AGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCC
TGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCC
CACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCG
GGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCC
ACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGG
GCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGG
CCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGG
GCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGAT
TTTAGCTGAGAGGGTTTTAATCTTGGAAACAATGATTGGGCTCTATGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCAC
CCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTG
GTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTA
ATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGG
CTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTC
ATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGT
CTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCA
GGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGG
GATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGACAGATGCCAGGAGGTAGATGTGTGCTGGCCAATAAAGGCC

>56378_56378_1_MYH9-EMID1_MYH9_chr22_36744949_ENST00000216181_EMID1_chr22_29610915_ENST00000334018_length(amino acids)=385AA_BP=
MQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTER
LKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAG
AVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPT
GPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPS

--------------------------------------------------------------
>56378_56378_2_MYH9-EMID1_MYH9_chr22_36744949_ENST00000216181_EMID1_chr22_29610915_ENST00000404755_length(transcript)=2385nt_BP=564nt
GAGGGCGGGGCGGGAAGGCGGCGAGGAGCCGAGCTGGGTGCGGTGAGGCGCGCAGATCACCGCGGTTCCTGGGCAGGGCACGGAAGGCTA
AGCAAGGCTGACCTGCTGCAGCTCCCGCCTCGTGCGCTCGCCCCACCCGGCCGCCGCCCGAGCGCTCGAGAAAGTCCTCTCGGGAGAAGC
AGCGCCTGTTCCCGGGGCAGATCCAGGTTCAGGTCCTGGCTATAAGTCACCATGGCACAGCAAGCTGCCGATAAGTATCTCTATGTGGAT
AAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAGCTGGTATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCA
GCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAGAATGGGAAGAAGGTGAAGGTGAACAAGGATGACATCCAG
AAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACGTGCCTCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAG
CGTTACTACTCAGGGCTCATCTACGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCATGTGCAGAATGGCACCTACCTTCA
GCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAGACCCACATACAAGGTGATGTACAA
GATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCC
CATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGAC
AGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCC
TGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCC
CACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCG
GGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCC
ACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGG
GCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACTGCGTGG
GGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTT
GCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAAACAATGATTGGGCTCTATGAACCAGAGCTGGGGTC
TGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGATCGTGGCCCCCAG
GAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCT
CCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACC
ATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGG
AGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACA
TGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCC
AGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCC
CCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGACAGATGCCAGGAG

>56378_56378_2_MYH9-EMID1_MYH9_chr22_36744949_ENST00000216181_EMID1_chr22_29610915_ENST00000404755_length(amino acids)=364AA_BP=
MQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTER
LKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAG
AVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEP
GPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSR

--------------------------------------------------------------
>56378_56378_3_MYH9-EMID1_MYH9_chr22_36744949_ENST00000216181_EMID1_chr22_29610915_ENST00000404820_length(transcript)=2454nt_BP=564nt
GAGGGCGGGGCGGGAAGGCGGCGAGGAGCCGAGCTGGGTGCGGTGAGGCGCGCAGATCACCGCGGTTCCTGGGCAGGGCACGGAAGGCTA
AGCAAGGCTGACCTGCTGCAGCTCCCGCCTCGTGCGCTCGCCCCACCCGGCCGCCGCCCGAGCGCTCGAGAAAGTCCTCTCGGGAGAAGC
AGCGCCTGTTCCCGGGGCAGATCCAGGTTCAGGTCCTGGCTATAAGTCACCATGGCACAGCAAGCTGCCGATAAGTATCTCTATGTGGAT
AAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAGCTGGTATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCA
GCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAGAATGGGAAGAAGGTGAAGGTGAACAAGGATGACATCCAG
AAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACGTGCCTCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAG
CGTTACTACTCAGGGCTCATCTACGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCATGTGCAGAATGGCACCTACCTTCA
GCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAGACCCACATACAAGGTGATGTACAA
GATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCC
CATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGAC
AGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCC
TGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCC
CACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCG
GGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCC
ACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGG
GCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGG
CCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGG
GCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGCTCCTAGCTTACAGAGCTTCCTGCAGCAGCAGGCTCA
GCTGGAGCTCCTGGCCAGACGGGTCACCCTCCTGGAAGCCATCATCTGGCCAGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCAC
AGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTG
AGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATAT
TTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAG
CAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTT
CGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGG
GGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCG
AGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAG
GTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGACAGATGCCAGGAGGTAGATGTGTGCTGGCCAATA

>56378_56378_3_MYH9-EMID1_MYH9_chr22_36744949_ENST00000216181_EMID1_chr22_29610915_ENST00000404820_length(amino acids)=387AA_BP=
MQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTER
LKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAG
AVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPT
GPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSLQSFLQQQAQLELLARRVTLLEAIIWPEPELGSGAGPAGTGT

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>56378_56378_4_MYH9-EMID1_MYH9_chr22_36744949_ENST00000401701_EMID1_chr22_29610915_ENST00000334018_length(transcript)=2303nt_BP=419nt
AGGGGCTGGTGTTCGGGGCTGCCCCGAGCCCAGCTCTGGGAGCTTATTTTGTCATCACAGTGGCACTGTCCTGGCTATAAGTCACCATGG
CACAGCAAGCTGCCGATAAGTATCTCTATGTGGATAAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAGCTGG
TATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCAGCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAGAATG
GGAAGAAGGTGAAGGTGAACAAGGATGACATCCAGAAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACGTGCC
TCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAGCGTTACTACTCAGGGCTCATCTACGAACTGGTGCTCCTATGTGGTGACCCGCACC
ATCTCATGCCATGTGCAGAATGGCACCTACCTTCAGCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGA
ACTGTGGTGAGACCCACATACAAGGTGATGTACAAGATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGC
GAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCCCATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCA
GGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGACAGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAG
CCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTC
CAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCA
CCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCT
CCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACT
GAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGT
GTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGA
CTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGGG
GAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAAACAATGATTGGGCTCTATGAACCAGAG
CTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGGATCGTG
GCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGACTCGGCC
AGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTCTCAGTC
CTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAGGCAGGC
CTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGCTGGGGC
TCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTCCCTCCT
TGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTCTTCCCT
CTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTGACAGAT

>56378_56378_4_MYH9-EMID1_MYH9_chr22_36744949_ENST00000401701_EMID1_chr22_29610915_ENST00000334018_length(amino acids)=385AA_BP=
MQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTER
LKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAG
AVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPT
GPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPS

--------------------------------------------------------------
>56378_56378_5_MYH9-EMID1_MYH9_chr22_36744949_ENST00000401701_EMID1_chr22_29610915_ENST00000404755_length(transcript)=2240nt_BP=419nt
AGGGGCTGGTGTTCGGGGCTGCCCCGAGCCCAGCTCTGGGAGCTTATTTTGTCATCACAGTGGCACTGTCCTGGCTATAAGTCACCATGG
CACAGCAAGCTGCCGATAAGTATCTCTATGTGGATAAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAGCTGG
TATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCAGCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAGAATG
GGAAGAAGGTGAAGGTGAACAAGGATGACATCCAGAAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACGTGCC
TCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAGCGTTACTACTCAGGGCTCATCTACGAACTGGTGCTCCTATGTGGTGACCCGCACC
ATCTCATGCCATGTGCAGAATGGCACCTACCTTCAGCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGA
ACTGTGGTGAGACCCACATACAAGGTGATGTACAAGATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGC
GAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCCCATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCA
GGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGACAGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAG
CCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTC
CAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCA
CCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCT
CCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACT
GAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGT
GTCCCTGGGAGTCCTGGTCACATAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGA
GACCCTGGTGAGAAGAGCCACTGGGGGGAGGGGTTGCACCAGCTACGCGAGGCTTTGAAGATTTTAGCTGAGAGGGTTTTAATCTTGGAA
ACAATGATTGGGCTCTATGAACCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGC
GGACATGCAACCAACTACCGGATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCA
GGCTTCCCCTCCTACCTGGACTCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTA
GGCCTTAGGGGTAAGCAGGTCTCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTT
CCCTCTGTGAAGTGGGGGGAGGCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAA
GGCACTGAGGGAGTCAGGAGCTGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCG
GGGAGCCCTCCTGTGCCCCTCCCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACC
GGGGGCTTCTTGCCTCAGTTCTTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGC

>56378_56378_5_MYH9-EMID1_MYH9_chr22_36744949_ENST00000401701_EMID1_chr22_29610915_ENST00000404755_length(amino acids)=364AA_BP=
MQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTER
LKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAG
AVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEP
GPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPELGSGAGPAGTGTPSLLRGKRGGHATNYRIVAPRSR

--------------------------------------------------------------
>56378_56378_6_MYH9-EMID1_MYH9_chr22_36744949_ENST00000401701_EMID1_chr22_29610915_ENST00000404820_length(transcript)=2309nt_BP=419nt
AGGGGCTGGTGTTCGGGGCTGCCCCGAGCCCAGCTCTGGGAGCTTATTTTGTCATCACAGTGGCACTGTCCTGGCTATAAGTCACCATGG
CACAGCAAGCTGCCGATAAGTATCTCTATGTGGATAAAAACTTCATCAACAATCCGCTGGCCCAGGCCGACTGGGCTGCCAAGAAGCTGG
TATGGGTGCCTTCCGACAAGAGTGGCTTTGAGCCAGCCAGCCTCAAGGAGGAGGTGGGCGAAGAGGCCATCGTGGAGCTGGTGGAGAATG
GGAAGAAGGTGAAGGTGAACAAGGATGACATCCAGAAGATGAACCCGCCCAAGTTCTCCAAGGTGGAGGACATGGCAGAGCTCACGTGCC
TCAACGAAGCCTCGGTGCTGCACAACCTCAAGGAGCGTTACTACTCAGGGCTCATCTACGAACTGGTGCTCCTATGTGGTGACCCGCACC
ATCTCATGCCATGTGCAGAATGGCACCTACCTTCAGCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGA
ACTGTGGTGAGACCCACATACAAGGTGATGTACAAGATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGC
GAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCCCATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCA
GGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGACAGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAG
CCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTC
CAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCA
CCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCT
CCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACT
GAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGT
GTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGA
CTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGGGGGAACCTGGCCCTAAGGGAGACCCTGGTGAGAAGAGCCACTGGGCT
CCTAGCTTACAGAGCTTCCTGCAGCAGCAGGCTCAGCTGGAGCTCCTGGCCAGACGGGTCACCCTCCTGGAAGCCATCATCTGGCCAGAA
CCAGAGCTGGGGTCTGGGGCGGGCCCTGCCGGCACAGGCACCCCCAGCCTCCTTCGGGGCAAGAGGGGCGGACATGCAACCAACTACCGG
ATCGTGGCCCCCAGGAGCCGGGACGAGAGAGGCTGAGGGTGGTGGCGGCCCCTGAGGCAGACCAGGCCAGGCTTCCCCTCCTACCTGGAC
TCGGCCAGCTGCCTCCAGGGACCGCCCGTCCATATTTATTAATGTCCTCAGGGTCCCTTCTGCCATCTAGGCCTTAGGGGTAAGCAGGTC
TCAGTCCTGGCACCATGCACATGTCTGAGGCTGAGCAAGGGCTGAGAGGAGAGGCTTGGGCCTCAGTTTCCCTCTGTGAAGTGGGGGGAG
GCAGGCCTTCAAGGAGGGATAGAGGTACAAGGCTTCGTCTCATCTGCTGTCTGAGCATCCAGGCCCAAAGGCACTGAGGGAGTCAGGAGC
TGGGGCTCGGCACATGCAGAGATGACAGGGCAGGGGGCAGTCTTCCTCCCCCTCCCCGACCAAACCTCGGGGAGCCCTCCTGTGCCCCTC
CCTCCTTGTTGTCCAGTGCTGGGCTCCCCACCCCGAGGTCAGGCTGCCCAATCCTCTGACTGGATCACCGGGGGCTTCTTGCCTCAGTTC
TTCCCTCTGAGCCCCCAGGCCCTCCCGCATCTCAGGTTGGGGATGGGGACATGGAGAGGAAGGGGCCGCCTACTCCTGCAAATGCTTGTG

>56378_56378_6_MYH9-EMID1_MYH9_chr22_36744949_ENST00000401701_EMID1_chr22_29610915_ENST00000404820_length(amino acids)=387AA_BP=
MQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTER
LKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAG
AVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPT
GPKGISGHPGEKGERGLRGEPGPQGSAGQRGEPGPKGDPGEKSHWAPSLQSFLQQQAQLELLARRVTLLEAIIWPEPELGSGAGPAGTGT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYH9-EMID1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYH9-EMID1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYH9-EMID1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource