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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYL6-ABI3BP (FusionGDB2 ID:56450)

Fusion Gene Summary for MYL6-ABI3BP

check button Fusion gene summary
Fusion gene informationFusion gene name: MYL6-ABI3BP
Fusion gene ID: 56450
HgeneTgene
Gene symbol

MYL6

ABI3BP

Gene ID

4637

25890

Gene namemyosin light chain 6ABI family member 3 binding protein
SynonymsESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SMNESHBP|TARSH
Cytomap

12q13.2

3q12.2

Type of geneprotein-codingprotein-coding
Descriptionmyosin light polypeptide 617 kDa myosin light chainmyosin light chain A3myosin light chain alkali 3myosin, light chain 6, alkali, smooth muscle and non-musclemyosin, light polypeptide 6, alkali, smooth muscle and non-muscletarget of Nesh-SH3ABI family, member 3 (NESH) binding proteinABI gene family member 3-binding proteinABI gene family, member 3 (NESH) binding proteinnesh-binding protein
Modification date2020031320200313
UniProtAcc.

Q7Z7G0

Ensembl transtripts involved in fusion geneENST00000348108, ENST00000293422, 
ENST00000547649, ENST00000548400, 
ENST00000548580, ENST00000549017, 
ENST00000550697, ENST00000536128, 
ENST00000547408, ENST00000548293, 
ENST00000549566, ENST00000551589, 
ENST00000551954, 		ENST00000471714, 
ENST00000383691, ENST00000284322, 
ENST00000495063, ENST00000532144, 
Fusion gene scores* DoF score34 X 17 X 10=57809 X 9 X 6=486
# samples 3610
** MAII scorelog2(36/5780*10)=-4.00500068105837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYL6 [Title/Abstract] AND ABI3BP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYL6(56555359)-ABI3BP(100557308), # samples:1
Anticipated loss of major functional domain due to fusion event.MYL6-ABI3BP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYL6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABI3BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3U9-01AMYL6chr12

56555359

-ABI3BPchr3

100557308

-


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Fusion Gene ORF analysis for MYL6-ABI3BP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000348108ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
3UTR-5UTRENST00000348108ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
3UTR-intronENST00000348108ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
3UTR-intronENST00000348108ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
3UTR-intronENST00000348108ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-5UTRENST00000293422ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-5UTRENST00000547649ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-5UTRENST00000548400ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-5UTRENST00000548580ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-5UTRENST00000549017ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-5UTRENST00000550697ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000293422ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000293422ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000293422ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000547649ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000547649ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000547649ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000548400ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000548400ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000548400ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000548580ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000548580ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000548580ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000549017ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000549017ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000549017ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000550697ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000550697ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
5CDS-intronENST00000550697ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
Frame-shiftENST00000293422ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
Frame-shiftENST00000547649ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
Frame-shiftENST00000549017ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
Frame-shiftENST00000550697ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
In-frameENST00000548400ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
In-frameENST00000548580ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-3CDSENST00000536128ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-3CDSENST00000547408ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-3CDSENST00000548293ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-3CDSENST00000549566ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-3CDSENST00000551589ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-3CDSENST00000551954ENST00000471714MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-5UTRENST00000536128ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-5UTRENST00000547408ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-5UTRENST00000548293ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-5UTRENST00000549566ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-5UTRENST00000551589ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-5UTRENST00000551954ENST00000383691MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000536128ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000536128ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000536128ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000547408ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000547408ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000547408ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000548293ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000548293ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000548293ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000549566ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000549566ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000549566ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000551589ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000551589ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000551589ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000551954ENST00000284322MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000551954ENST00000495063MYL6chr12

56555359

-ABI3BPchr3

100557308

-
intron-intronENST00000551954ENST00000532144MYL6chr12

56555359

-ABI3BPchr3

100557308

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000548580MYL6chr1256555359-ENST00000471714ABI3BPchr3100557308-523552848238951137
ENST00000548400MYL6chr1256555359-ENST00000471714ABI3BPchr3100557308-528057352739401137

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000548580ENST00000471714MYL6chr1256555359-ABI3BPchr3100557308-0.0015711590.99842876
ENST00000548400ENST00000471714MYL6chr1256555359-ABI3BPchr3100557308-0.0016420060.99835795

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Fusion Genomic Features for MYL6-ABI3BP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYL6-ABI3BP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56555359/chr3:100557308)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABI3BP

Q7Z7G0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYL6chr12:56555359chr3:100557308ENST00000547649-66119_151205152.0DomainEF-hand 3
HgeneMYL6chr12:56555359chr3:100557308ENST00000547649-667_42205152.0DomainEF-hand 1
HgeneMYL6chr12:56555359chr3:100557308ENST00000547649-6684_119205152.0DomainEF-hand 2
HgeneMYL6chr12:56555359chr3:100557308ENST00000550697-77119_151220133.33333333333334DomainEF-hand 3
HgeneMYL6chr12:56555359chr3:100557308ENST00000550697-777_42220133.33333333333334DomainEF-hand 1
HgeneMYL6chr12:56555359chr3:100557308ENST00000550697-7784_119220133.33333333333334DomainEF-hand 2
TgeneABI3BPchr12:56555359chr3:100557308ENST00000284322035419_75601076.0Compositional biasNote=Pro-rich
TgeneABI3BPchr12:56555359chr3:100557308ENST00000284322035123_22101076.0DomainFibronectin type-III 1
TgeneABI3BPchr12:56555359chr3:100557308ENST00000284322035840_93301076.0DomainFibronectin type-III 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYL6chr12:56555359chr3:100557308ENST00000548293-16119_1510152.0DomainEF-hand 3
HgeneMYL6chr12:56555359chr3:100557308ENST00000548293-167_420152.0DomainEF-hand 1
HgeneMYL6chr12:56555359chr3:100557308ENST00000548293-1684_1190152.0DomainEF-hand 2


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Fusion Gene Sequence for MYL6-ABI3BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56450_56450_1_MYL6-ABI3BP_MYL6_chr12_56555359_ENST00000548400_ABI3BP_chr3_100557308_ENST00000471714_length(transcript)=5280nt_BP=573nt
CGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCGAACAGAGA
TGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACCTATGAGGATTATG
TCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTGGGTGAGAAGA
TGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTATGAAGCGTTTGTGAGGCATATCCTGT
CGGGGTGACGGGCCCATGGGGCGGAGCTCGTCCGCATGGTGCTGAATGGCTGAGGACCTTCCCAGTCTCCCCAGAGTCCGTGCCTTTCCC
TGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCCG
TCAGCATTCACCAAATAAACTTGCTCTCTGGGCCCTCAAAACCATCTGAGAGACCTAAAACCACACACAGACCAGATGCACCTCAAATTC
AGCCTGGTTCAAAACCACCAAAACAATTACTTCCTAAACCCCAAACCACAGCAGAACCAGACATGCCACCAACTAAATCCGTCTCTGAGC
CTGTTCCATTTGAAACTGAAGCTCCCTCAATGACCATAGTTCCCACCACAGACATTGAGCCTGTAACTGTGAGAACTGAGGCTACAGTGA
CAACATTAGCTCCAAAAACATCGCAACGAACAAGAACACGTCGTCCACGTCCCAAACATAAAACCACGCCACGCCCAGAGACACTGCAGA
CCAAACTAGACTTTGGACCTATTACTCCTGGGACATCTTCAGCTCCAACAACAACAACAAAAAGAACCCGTCGTCCACATCCCAAACCTA
AAACCACGCCCCATCCAGAAGTACCTCAAACTAAACTGGTTCCTGCCACAATCCTCGAACCAGTTCTTAGAACTGAGGCTTCAGGGACAA
CAGCAGCTCCCAAAGTGCCTCAACGAACTCATCGTCCACATCCCAAACCTAAAACCACACTGAGTCCCGAAGAGCTTCAGACTGAACTGG
TTCCTGCTACAATCTTTGAACCAGTTTCTCCTATAAAAGAGGCTCCAGGGACAACATTCGTTCCTGTTACAGACCTCGAGCCTGTTACTT
TTAGAACTGAGATCCCTGCAACAACCTTAGCTACCAAAACATCAAAAAGAACCCGCCCTCCACGTCCCAGACCTAAAACTACACCGAGCC
CTCAGGCACCTGAGACCAAACCTGTTCCTGCTACAGTCCTAGAACCTGTCACTCTTAGACCTGAGGCCTCAACAACATTAGCTTCCAAAA
CATCACAACGGACACGTCGTCCACGTCTCAGAACAAAAACCACACCACGTCCTGAAGCACCTGAATCCAAACCAGTTCCTACTGCGGAGC
TCAAACCTGTTACACTCAGAACTGAGACTTGGGTGACAACACAAGCTCCTAAAACATCACAACGAACTCGTCGTCCACGTCCCAAAACTA
AAACCACACCAAGTCCTGAGGTTCCTCAAACCAAACTGGTTCCTTCTACAGATCTTGAACCTGGTACTCTCAGAACTGAAGCTCCAAAAA
CCATGGTTGTTACTACAGTCCTTGAACCTGACACTTTTAGAACCAAGTTTCCAGAAACAACGTTAGCTCCTAAAACACAACGGACACGTC
GTCCCCGTCCCAGACCCAAAACTACATCAAGTCCTGAAGTACCTCAGAACAAATCGGTTTCTGTTACAGGCTTTGAACCTGTTGTTCATA
GTACTGATGCTCCAGGAACAACATTTGCTCTGACTGAACTGCAAACTCTTATTTTGAAACCAGTGACATCACCAAGCCTAGAAATGACAG
AAAGTCAACCTGTTTCTGATGTTCTGGAATCGGTTACACTTAGTACTGAGTCACCAAAGGAGACCATAGCACCAGCCAAAACAGACTATG
TATATCCCACTGCCAAAGCACCACTCTGGCCAGAGGAGCCAAAGACTGAAGTTGTGGAATCTATTACATATGTATCTGAACCACCTGAGA
CCACACTAGAAACGTCGCCTCTGCCTTCTCAATCTATAACCCTACCCAGCCCAGATGAGCCTCAGACTGAACCTGCTCCCAAGCAGACAC
CACGTGCTCCTCCTAAGCCAAAAACATCACCACGCCCAAGAATCCCACAAACACAACCAGTTCCTAAGGTGCCCCAGCGTGTTACTGCAA
AACCAAAAACGTCACCAAGTCCAGAAGTGTCATACACCACACCTGCTCCAAAAGATGTGCTCCTTCCTCATAAACCATACCCTGAGGTCT
CTCAGAGCGAACCTGCTCCTCTAGAGACACGAGGCATCCCTTTTATACCCATGATTTCCCCAAGTCCTAGTCAAGAGGAACTACAGACCA
CTCTGGAAGAAACAGACCAATCCACCCAAGAACCTTTCACAACTAAGATTCCACGAACAACTGAACTAGCAAAGACAACTCAGGCGCCAC
ACAGATTTTATACTACTGTGAGGCCCAGAACATCTGACAAGCCACACATCAGACCTGTTCTGAATAGGACAACTACAAGACCTACTAGGC
CCAAACCCAGTGGGATGCCCAGTGGGAATGGAGTGGGAACAGGGGTCAAGCAAGCACCCAGGCCATCAGGTGCTGATAGAAATGTATCAG
TGGACTCTACCCACCCCACTAAAAAGCCAGGGACTCGCCGCCCACCCTTGCCACCCAGACCTACACACCCACGAAGAAAACCTTTACCAC
CAAATAATGTCACTGGAAAGCCAGGAAGTGCAGGAATCATTTCATCAGGCCCAATAACTACACCACCCCTGAGGTCAACACCCAGGCCTA
CTGGAACTCCCTTGGAGAGAATAGAGACAGATATAAAGCAACCAACAGTTCCTGCCTCTGGAGAAGAACTGGAAAATATAACTGACTTTA
GCTCAAGCCCAACAAGAGAAACTGATCCTCTTGGGAAGCCAAGATTCAAAGGACCTCATGTGCGATACATCCAAAAGCCTGACAACAGTC
CCTGCTCCATTACTGACTCTGTCAAACGGTTCCCCAAAGAGGAGGCCACAGAGGGGAATGCCACCAGCCCACCACAGAACCCACCCACCA
ACCTCACTGTGGTCACCGTGGAAGGGTGCCCCTCATTTGTCATCTTGGACTGGGAAAAGCCACTAAATGACACTGTCACTGAATATGAAG
TTATATCCAGAGAAAATGGGTCATTCAGTGGGAAGAACAAGTCCATTCAAATGACAAATCAGACATTTTCCACAGTAGAAAATCTGAAAC
CAAACACGAGTTATGAATTCCAGGTGAAACCCAAAAACCCGCTTGGTGAAGGCCCGGTCAGCAACACAGTGGCATTCAGTACTGAATCAG
CGGACCCAAGAGTGAGTGAGCCAGTTTCTGCAGGAAGAGATGCCATCTGGACTGAAAGACCCTTTAATTCAGACTCTTACTCAGAGTGTA
AGGGCAAACAATATGTCAAAAGGACATGGTATAAAAAATTTGTAGGAGTGCAGCTGTGCAACTCTCTCAGATACAAGATTTACTTGAGCG
ACTCCCTCACAGGAAAATTTTATAACATAGGTGATCAGAGGGGCCATGGAGAAGATCACTGCCAGTTTGTGGATTCATTTTTAGATGGAC
GCACTGGGCAGCAACTCACTTCTGACCAGTTACCAATCAAAGAAGGTTATTTCAGAGCAGTTCGCCAGGAACCTGTCCAATTTGGAGAAA
TAGGTGGTCACACCCAAATCAATTATGTTCAGTGGTATGAATGTGGGACTACAATTCCTGGAAAATGGTAGATGCTGCACAAAGTTACCT
TCTGTTTCATCATTGCAAACAAAAATCATTGAAAATACTATGCCGCATTCATTTAAAGCTATTTTGTTTACTATGTATAAAAGTCTACAA
TCTAATTAATAGCAATACTAGATGTTTATTATTAGAAAAGATTGCTGAGAGTATTTATCAGGTTTTACAAAGTCATTTTAAGAAAGCAAG
ATACTGATGTTAACAGAATAACATTTTTGGGGAAGCTGGCTCCCTATTCATGGTATTTTAAGAGATCATTTGTATATTATTTATCACACT
GTTGTAATGATGTTTTGAGATACTTTTATAACAAAATTAACATCAAAAAGGTATATACTTTTTAAAAAAAATTTACTTTTATTGATGTGT
ACTCTTCCTATTGATGAGTTAATTCCATAAATCTCTACTTAGTTTAACTTATTGGATCAAATTATCTTCAGCATGTATATCTGGGGAAAA
AAGGTCCGAATTTTCACATTTATATTTAAACTTCAATTTTTTATATTTAAACTTCAATTTTTTAGCAACAGCTGAATAGCTTTGCGGAGG
AGTTTAATAGTTACACATTCATGCTAATATACATTTCCTTTAAACATCCACAAATTCTTAAAAAGATTGAATCAGTAAATTTCATTTCAG
CTAAAAATGGAGTCTAATATATTGTTTCAAAAGATACATTTTTACCCACCATAAATGTTACAATATCTGAATATGCTTTGTCAAACTATC
CCTTTATGCAATCGTCTTCATATTGTTTTTATGATTCTAATCAAGCTGTATGTAGAGACTGAATGTGAAGTCAAGTCTGAGCACAAAAAG
ATAATGCACGATGAGATTGCCTACCATTTTATAGGATATTTACTATGTATTTATACGTTAAGACCTCTATGAATGAATGTATCAGAGAAT
GTCTTTGTAACTGTTTAATTCAATCTGTAATAAAAATCTAACTAACTAACTCATTTATTTCTATTAAAAAGGTATTGTCCTTTAGGCGGG
GAATGGGAATCCTTGCTGCACTGTTGCAGTCATTCTGAAAGGACCTTTCCCTGTACTTACCTTTCAACATGCTTCAATCTTATCAACGCT
ACATTTTGTATTTTTCAAACAAGTATAAATTCTGCAATAAAGAGATGTAGTTTTTTTTTAAGATTGAGTTTTTGTTTGTTATTTCTGAAT
GGTTCATCAGTATGTTAACTATACCTTTTATCGAGAAGGAAAATCACTAAGTTTTATTCAGGCTCTACCAACCCCCATTATATCTACTGT

>56450_56450_1_MYL6-ABI3BP_MYL6_chr12_56555359_ENST00000548400_ABI3BP_chr3_100557308_ENST00000471714_length(amino acids)=1137AA_BP=264
MMFAVSIHQINLLSGPSKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPSMTIVPTTDIEPVTVRT
EATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLVPATILEPVLRTE
ASGTTAAPKVPQRTHRPHPKPKTTLSPEELQTELVPATIFEPVSPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPK
TTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPESKPVPTAELKPVTLRTETWVTTQAPKTSQRTRRP
RPKTKTTPSPEVPQTKLVPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPETTLAPKTQRTRRPRPRPKTTSSPEVPQNKSVSVTGFE
PVVHSTDAPGTTFALTELQTLILKPVTSPSLEMTESQPVSDVLESVTLSTESPKETIAPAKTDYVYPTAKAPLWPEEPKTEVVESITYVS
EPPETTLETSPLPSQSITLPSPDEPQTEPAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKP
YPEVSQSEPAPLETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPHRFYTTVRPRTSDKPHIRPVLNRTTT
RPTRPKPSGMPSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGIISSGPITTPPLRS
TPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQ
NPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAF
STESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDS

--------------------------------------------------------------
>56450_56450_2_MYL6-ABI3BP_MYL6_chr12_56555359_ENST00000548580_ABI3BP_chr3_100557308_ENST00000471714_length(transcript)=5235nt_BP=528nt
GCCGAGAGTCGGAGCCATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGAGA
TGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACCTATGAGGATTATG
TCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTGGGTGAGAAGA
TGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTATGAAGAGCTCGTCCGCATGGTGCTGA
ATGGCTGAGGACCTTCCCAGTCTCCCCAGAGTCCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTG
TCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCCGTCAGCATTCACCAAATAAACTTGCTCTCTGGGCCCTCAAAACCAT
CTGAGAGACCTAAAACCACACACAGACCAGATGCACCTCAAATTCAGCCTGGTTCAAAACCACCAAAACAATTACTTCCTAAACCCCAAA
CCACAGCAGAACCAGACATGCCACCAACTAAATCCGTCTCTGAGCCTGTTCCATTTGAAACTGAAGCTCCCTCAATGACCATAGTTCCCA
CCACAGACATTGAGCCTGTAACTGTGAGAACTGAGGCTACAGTGACAACATTAGCTCCAAAAACATCGCAACGAACAAGAACACGTCGTC
CACGTCCCAAACATAAAACCACGCCACGCCCAGAGACACTGCAGACCAAACTAGACTTTGGACCTATTACTCCTGGGACATCTTCAGCTC
CAACAACAACAACAAAAAGAACCCGTCGTCCACATCCCAAACCTAAAACCACGCCCCATCCAGAAGTACCTCAAACTAAACTGGTTCCTG
CCACAATCCTCGAACCAGTTCTTAGAACTGAGGCTTCAGGGACAACAGCAGCTCCCAAAGTGCCTCAACGAACTCATCGTCCACATCCCA
AACCTAAAACCACACTGAGTCCCGAAGAGCTTCAGACTGAACTGGTTCCTGCTACAATCTTTGAACCAGTTTCTCCTATAAAAGAGGCTC
CAGGGACAACATTCGTTCCTGTTACAGACCTCGAGCCTGTTACTTTTAGAACTGAGATCCCTGCAACAACCTTAGCTACCAAAACATCAA
AAAGAACCCGCCCTCCACGTCCCAGACCTAAAACTACACCGAGCCCTCAGGCACCTGAGACCAAACCTGTTCCTGCTACAGTCCTAGAAC
CTGTCACTCTTAGACCTGAGGCCTCAACAACATTAGCTTCCAAAACATCACAACGGACACGTCGTCCACGTCTCAGAACAAAAACCACAC
CACGTCCTGAAGCACCTGAATCCAAACCAGTTCCTACTGCGGAGCTCAAACCTGTTACACTCAGAACTGAGACTTGGGTGACAACACAAG
CTCCTAAAACATCACAACGAACTCGTCGTCCACGTCCCAAAACTAAAACCACACCAAGTCCTGAGGTTCCTCAAACCAAACTGGTTCCTT
CTACAGATCTTGAACCTGGTACTCTCAGAACTGAAGCTCCAAAAACCATGGTTGTTACTACAGTCCTTGAACCTGACACTTTTAGAACCA
AGTTTCCAGAAACAACGTTAGCTCCTAAAACACAACGGACACGTCGTCCCCGTCCCAGACCCAAAACTACATCAAGTCCTGAAGTACCTC
AGAACAAATCGGTTTCTGTTACAGGCTTTGAACCTGTTGTTCATAGTACTGATGCTCCAGGAACAACATTTGCTCTGACTGAACTGCAAA
CTCTTATTTTGAAACCAGTGACATCACCAAGCCTAGAAATGACAGAAAGTCAACCTGTTTCTGATGTTCTGGAATCGGTTACACTTAGTA
CTGAGTCACCAAAGGAGACCATAGCACCAGCCAAAACAGACTATGTATATCCCACTGCCAAAGCACCACTCTGGCCAGAGGAGCCAAAGA
CTGAAGTTGTGGAATCTATTACATATGTATCTGAACCACCTGAGACCACACTAGAAACGTCGCCTCTGCCTTCTCAATCTATAACCCTAC
CCAGCCCAGATGAGCCTCAGACTGAACCTGCTCCCAAGCAGACACCACGTGCTCCTCCTAAGCCAAAAACATCACCACGCCCAAGAATCC
CACAAACACAACCAGTTCCTAAGGTGCCCCAGCGTGTTACTGCAAAACCAAAAACGTCACCAAGTCCAGAAGTGTCATACACCACACCTG
CTCCAAAAGATGTGCTCCTTCCTCATAAACCATACCCTGAGGTCTCTCAGAGCGAACCTGCTCCTCTAGAGACACGAGGCATCCCTTTTA
TACCCATGATTTCCCCAAGTCCTAGTCAAGAGGAACTACAGACCACTCTGGAAGAAACAGACCAATCCACCCAAGAACCTTTCACAACTA
AGATTCCACGAACAACTGAACTAGCAAAGACAACTCAGGCGCCACACAGATTTTATACTACTGTGAGGCCCAGAACATCTGACAAGCCAC
ACATCAGACCTGTTCTGAATAGGACAACTACAAGACCTACTAGGCCCAAACCCAGTGGGATGCCCAGTGGGAATGGAGTGGGAACAGGGG
TCAAGCAAGCACCCAGGCCATCAGGTGCTGATAGAAATGTATCAGTGGACTCTACCCACCCCACTAAAAAGCCAGGGACTCGCCGCCCAC
CCTTGCCACCCAGACCTACACACCCACGAAGAAAACCTTTACCACCAAATAATGTCACTGGAAAGCCAGGAAGTGCAGGAATCATTTCAT
CAGGCCCAATAACTACACCACCCCTGAGGTCAACACCCAGGCCTACTGGAACTCCCTTGGAGAGAATAGAGACAGATATAAAGCAACCAA
CAGTTCCTGCCTCTGGAGAAGAACTGGAAAATATAACTGACTTTAGCTCAAGCCCAACAAGAGAAACTGATCCTCTTGGGAAGCCAAGAT
TCAAAGGACCTCATGTGCGATACATCCAAAAGCCTGACAACAGTCCCTGCTCCATTACTGACTCTGTCAAACGGTTCCCCAAAGAGGAGG
CCACAGAGGGGAATGCCACCAGCCCACCACAGAACCCACCCACCAACCTCACTGTGGTCACCGTGGAAGGGTGCCCCTCATTTGTCATCT
TGGACTGGGAAAAGCCACTAAATGACACTGTCACTGAATATGAAGTTATATCCAGAGAAAATGGGTCATTCAGTGGGAAGAACAAGTCCA
TTCAAATGACAAATCAGACATTTTCCACAGTAGAAAATCTGAAACCAAACACGAGTTATGAATTCCAGGTGAAACCCAAAAACCCGCTTG
GTGAAGGCCCGGTCAGCAACACAGTGGCATTCAGTACTGAATCAGCGGACCCAAGAGTGAGTGAGCCAGTTTCTGCAGGAAGAGATGCCA
TCTGGACTGAAAGACCCTTTAATTCAGACTCTTACTCAGAGTGTAAGGGCAAACAATATGTCAAAAGGACATGGTATAAAAAATTTGTAG
GAGTGCAGCTGTGCAACTCTCTCAGATACAAGATTTACTTGAGCGACTCCCTCACAGGAAAATTTTATAACATAGGTGATCAGAGGGGCC
ATGGAGAAGATCACTGCCAGTTTGTGGATTCATTTTTAGATGGACGCACTGGGCAGCAACTCACTTCTGACCAGTTACCAATCAAAGAAG
GTTATTTCAGAGCAGTTCGCCAGGAACCTGTCCAATTTGGAGAAATAGGTGGTCACACCCAAATCAATTATGTTCAGTGGTATGAATGTG
GGACTACAATTCCTGGAAAATGGTAGATGCTGCACAAAGTTACCTTCTGTTTCATCATTGCAAACAAAAATCATTGAAAATACTATGCCG
CATTCATTTAAAGCTATTTTGTTTACTATGTATAAAAGTCTACAATCTAATTAATAGCAATACTAGATGTTTATTATTAGAAAAGATTGC
TGAGAGTATTTATCAGGTTTTACAAAGTCATTTTAAGAAAGCAAGATACTGATGTTAACAGAATAACATTTTTGGGGAAGCTGGCTCCCT
ATTCATGGTATTTTAAGAGATCATTTGTATATTATTTATCACACTGTTGTAATGATGTTTTGAGATACTTTTATAACAAAATTAACATCA
AAAAGGTATATACTTTTTAAAAAAAATTTACTTTTATTGATGTGTACTCTTCCTATTGATGAGTTAATTCCATAAATCTCTACTTAGTTT
AACTTATTGGATCAAATTATCTTCAGCATGTATATCTGGGGAAAAAAGGTCCGAATTTTCACATTTATATTTAAACTTCAATTTTTTATA
TTTAAACTTCAATTTTTTAGCAACAGCTGAATAGCTTTGCGGAGGAGTTTAATAGTTACACATTCATGCTAATATACATTTCCTTTAAAC
ATCCACAAATTCTTAAAAAGATTGAATCAGTAAATTTCATTTCAGCTAAAAATGGAGTCTAATATATTGTTTCAAAAGATACATTTTTAC
CCACCATAAATGTTACAATATCTGAATATGCTTTGTCAAACTATCCCTTTATGCAATCGTCTTCATATTGTTTTTATGATTCTAATCAAG
CTGTATGTAGAGACTGAATGTGAAGTCAAGTCTGAGCACAAAAAGATAATGCACGATGAGATTGCCTACCATTTTATAGGATATTTACTA
TGTATTTATACGTTAAGACCTCTATGAATGAATGTATCAGAGAATGTCTTTGTAACTGTTTAATTCAATCTGTAATAAAAATCTAACTAA
CTAACTCATTTATTTCTATTAAAAAGGTATTGTCCTTTAGGCGGGGAATGGGAATCCTTGCTGCACTGTTGCAGTCATTCTGAAAGGACC
TTTCCCTGTACTTACCTTTCAACATGCTTCAATCTTATCAACGCTACATTTTGTATTTTTCAAACAAGTATAAATTCTGCAATAAAGAGA
TGTAGTTTTTTTTTAAGATTGAGTTTTTGTTTGTTATTTCTGAATGGTTCATCAGTATGTTAACTATACCTTTTATCGAGAAGGAAAATC
ACTAAGTTTTATTCAGGCTCTACCAACCCCCATTATATCTACTGTTTGTTTATGTCCTAAATTAACCTTTCATCCTATGAAGTAATAAAG

>56450_56450_2_MYL6-ABI3BP_MYL6_chr12_56555359_ENST00000548580_ABI3BP_chr3_100557308_ENST00000471714_length(amino acids)=1137AA_BP=264
MMFAVSIHQINLLSGPSKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPSMTIVPTTDIEPVTVRT
EATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLVPATILEPVLRTE
ASGTTAAPKVPQRTHRPHPKPKTTLSPEELQTELVPATIFEPVSPIKEAPGTTFVPVTDLEPVTFRTEIPATTLATKTSKRTRPPRPRPK
TTPSPQAPETKPVPATVLEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPESKPVPTAELKPVTLRTETWVTTQAPKTSQRTRRP
RPKTKTTPSPEVPQTKLVPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPETTLAPKTQRTRRPRPRPKTTSSPEVPQNKSVSVTGFE
PVVHSTDAPGTTFALTELQTLILKPVTSPSLEMTESQPVSDVLESVTLSTESPKETIAPAKTDYVYPTAKAPLWPEEPKTEVVESITYVS
EPPETTLETSPLPSQSITLPSPDEPQTEPAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKP
YPEVSQSEPAPLETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPHRFYTTVRPRTSDKPHIRPVLNRTTT
RPTRPKPSGMPSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGIISSGPITTPPLRS
TPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQ
NPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAF
STESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYL6-ABI3BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYL6-ABI3BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYL6-ABI3BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource