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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:APPBP2-HEATR6 (FusionGDB2 ID:5654)

Fusion Gene Summary for APPBP2-HEATR6

Fusion gene summary

Fusion gene information	Fusion gene name: APPBP2-HEATR6
	Fusion gene ID: 5654
		Hgene	Tgene
	Gene symbol	APPBP2	HEATR6
	Gene ID	10513	63897
	Gene name	amyloid beta precursor protein binding protein 2	HEAT repeat containing 6
	Synonyms	APP-BP2\|HS.84084\|PAT1	ABC1
	Cytomap	17q23.2	17q23.1
	Type of gene	protein-coding	protein-coding
	Description	amyloid protein-binding protein 2amyloid beta precursor protein (cytoplasmic tail) binding protein 2protein interacting with APP tail 1	HEAT repeat-containing protein 6amplified in breast cancer 1amplified in breast cancer protein 1
	Modification date	20200313	20200313
	UniProtAcc	Q92624	Q6AI08
	Ensembl transtripts involved in fusion gene	ENST00000083182, ENST00000592995,	ENST00000585712, ENST00000184956, ENST00000585976,
Fusion gene scores	* DoF score	13 X 9 X 8=936	11 X 10 X 6=660
	# samples	15	12
	** MAII score	log2(15/936*10)=-2.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/660*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: APPBP2 [Title/Abstract] AND HEATR6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	APPBP2(58529241)-HEATR6(58134764), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	APPBP2	GO:0046907	intracellular transport	9843960

Fusion gene breakpoints across APPBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HEATR6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A1-A0SN-01A	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-

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Fusion Gene ORF analysis for APPBP2-HEATR6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000083182	ENST00000585712	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-
In-frame	ENST00000083182	ENST00000184956	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-
In-frame	ENST00000083182	ENST00000585976	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-
intron-3CDS	ENST00000592995	ENST00000184956	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-
intron-3CDS	ENST00000592995	ENST00000585976	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-
intron-intron	ENST00000592995	ENST00000585712	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000083182	APPBP2	chr17	58529241	-	ENST00000184956	HEATR6	chr17	58134764	-	3984	1792	60	3614	1184
ENST00000083182	APPBP2	chr17	58529241	-	ENST00000585976	HEATR6	chr17	58134764	-	3350	1792	60	3278	1072

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000083182	ENST00000184956	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-	0.000657675	0.99934226
ENST00000083182	ENST00000585976	APPBP2	chr17	58529241	-	HEATR6	chr17	58134764	-	0.000667643	0.99933237

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Fusion Genomic Features for APPBP2-HEATR6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APPBP2-HEATR6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:58529241/chr17:58134764)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
APPBP2 Q92624	HEATR6 Q6AI08
FUNCTION: May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. {ECO:0000269\|PubMed:9843960}.	FUNCTION: Amplification-dependent oncogene.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

120_153

501

586.0

Repeat

Note=TPR 2

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

206_239

501

586.0

Repeat

Note=TPR 3

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

288_321

501

586.0

Repeat

Note=TPR 4

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

333_367

501

586.0

Repeat

Note=TPR 5

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

429_462

501

586.0

Repeat

Note=TPR 6

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

50_83

501

586.0

Repeat

Note=TPR 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

471_505

501

586.0

Repeat

Note=TPR 7

Hgene

APPBP2

chr17:58529241

chr17:58134764

ENST00000083182

514_547

501

586.0

Repeat

Note=TPR 8

Tgene

HEATR6

chr17:58529241

chr17:58134764

ENST00000184956

315_325

574

1182.0

Compositional bias

Note=Poly-Lys

Tgene

HEATR6

chr17:58529241

chr17:58134764

ENST00000184956

330_335

574

1182.0

Compositional bias

Note=Poly-Glu

Tgene

HEATR6

chr17:58529241

chr17:58134764

ENST00000184956

383_390

574

1182.0

Compositional bias

Note=Poly-Ser

Tgene

HEATR6

chr17:58529241

chr17:58134764

ENST00000184956

159_198

574

1182.0

Repeat

Note=HEAT 1

Tgene

HEATR6

chr17:58529241

chr17:58134764

ENST00000184956

452_490

574

1182.0

Repeat

Note=HEAT 2

Tgene

HEATR6

chr17:58529241

chr17:58134764

ENST00000184956

515_552

574

1182.0

Repeat

Note=HEAT 3

Tgene

HEATR6

chr17:58529241

chr17:58134764

ENST00000184956

558_595

574

1182.0

Repeat

Note=HEAT 4

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Fusion Gene Sequence for APPBP2-HEATR6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5654_5654_1_APPBP2-HEATR6_APPBP2_chr17_58529241_ENST00000083182_HEATR6_chr17_58134764_ENST00000184956_length(transcript)=3984nt_BP=1792nt
GAGATCAGCGCTGGGACGGAACCCGGGTTCCTCTCGAACCGGGATTGTGACGCTTTTGGCCTGGCTGGCCGCTGTTTTCTGTCCCACTTT
TTACTCGGGCCTGCGTCCGCTGCCGCCGTCCCTCAGTTTGCCCCCGGAGGAGGCAGGGCGGCCGTGCCTTCTGCCGTGCGCCCGCGTGGC
TGCCACCGCCCCTCCGAATCCTCCGGGGCCGCAGAGGGGTTCGCTACGGAGGGAGGTGGGGGCCTTCGGGAGGAGGAGGCGGAGGAGGCG
GAGGAGGAGGGAAGGAAGATGGCGGCCGTGGAACTAGAGTGGATCCCAGAGACTCTCTATAACACCGCCATCTCCGCTGTCGTGGACAAC
TACATCCGCTCCCGCCGAGACATCCGCTCCTTGCCCGAGAACATCCAGTTTGATGTTTACTACAAGCTTTACCAACAGGGACGCTTATGT
CAACTGGGCAGTGAATTTTGTGAATTGGAAGTTTTTGCTAAAGTACTGAGAGCTTTGGATAAAAGACATTTGCTTCATCATTGTTTTCAG
GCTTTGATGGATCATGGTGTTAAAGTTGCTTCAGTCTTGGCCTACTCATTCAGTAGGCGGTGCTCTTATATAGCAGAATCAGATGCTGCA
GTAAAGGAAAAAGCCATTCAGGTTGGCTTTGTTTTAGGTGGCTTTCTTTCAGATGCAGGCTGGTACAGTGATGCTGAGAAAGTTTTTCTG
TCCTGCCTTCAGTTGTGTACTCTACACGATGAGATGCTTCATTGGTTTCGTGCAGTAGAATGTTGTGTGAGGTTGCTTCATGTGCGAAAT
GGAAACTGCAAATATCATTTGGGTGAAGAAACATTTAAATTAGCTCAGACATATATGGATAAACTATCAAAACATGGCCAGCAAGCAAAT
AAAGCTGCACTCTATGGAGAACTGTGTGCACTCCTATTTGCAAAAAGTCACTATGATGAGGCATACAAATGGTGCATCGAGGCAATGAAA
GAAATTACAGCAGGCTTACCAGTGAAAGTTGTGGTGGATGTCTTAAGACAAGCTTCTAAGGCTTGTGTAGTAAAACGTGAATTTAAGAAG
GCAGAACAGTTAATTAAACATGCAGTGTATTTGGCACGGGATCATTTTGGATCCAAACACCCAAAATATTCTGATACACTGCTAGATTAT
GGGTTCTACTTACTCAATGTAGATAATATCTGTCAGTCTGTTGCAATTTATCAGGCAGCCCTTGACATTAGACAGTCAGTGTTTGGTGGC
AAAAATATCCACGTAGCAACAGCTCATGAAGATTTGGCCTACTCTTCTTATGTCCACCAGTATAGCTCTGGGAAATTTGACAATGCACTA
TTTCATGCAGAAAGAGCTATTGGTATCATTACCCACATCCTACCTGAAGATCATCTTCTTTTGGCTTCTTCAAAGAGGGTGAAAGCACTT
ATTTTAGAGGAGATTGCAATTGATTGTCATAATAAGGAAACTGAACAGAGGCTGCTTCAAGAAGCTCATGATTTGCACCTGTCTTCACTC
CAACTAGCTAAAAAAGCTTTTGGGGAATTTAATGTACAGACTGCAAAACACTATGGAAACCTTGGAAGACTTTATCAGTCAATGAGAAAA
TTTAAGGAAGCTGAAGAAATGCACATCAAAGCAATTCAGATTAAAGAACAACTTCTTGGTCAAGAAGATTATGAAGTAGCCCTTTCAGTG
GGACATCTGGCTTCTTTATATAATTATGACATGAATCAGTATGAAAATGCTGAGAAACTTTATTTGCGATCTATAGCAATTGATGTTAAT
GTTCGTGTGTCAAGTCTCACACTCTTGGGAGCTATAGTGTCCACCCACGCACCTTTACCTGAAGTCCAACTACTTCTGCAACAGCCATGT
TCTTCTGGACTCGGTAATAGCAATTCAGCAACCCCTCACCTCAGCCCTCCTGATTGGTGGAAGAAAGCCCCTGCAGGACCCTCTCTGGAA
GAAACGTCAGTTAGCTCACCTAAGGGGTCTTCAGAGCCCTGCTGGCTCATTCGACTCTGCATTTCCATTGTCGTACTGCCCAAGGAGGAT
TCCTGTTCAGGTAGCGATGCTGGCTCTGCAGCAGGAAGCACCTACGAACCATCCCCCATGCGACTGGAGGCCTTACAGGTATTGACTCTT
CTGGCAAGGGGCTACTTTTCAATGACTCAAGCCTACTTGATGGAGCTTGGAGAGGTGATTTGCAAGTGCATGGGGGAAGCAGATCCATCC
ATTCAGCTTCATGGAGCAAAGCTTCTGGAAGAACTGGGCACAGGCTTAATACAGCAGTATAAACCAGACTCCACTGCAGCACCTGATCAG
AGAGCACCAGTCTTCTTGGTGGTGATGTTCTGGACTATGATGCTGAACGGTCCTTTACCCAGAGCCCTGCAGAATTCAGAACACCCAACT
CTCCAGGCGAGCGCCTGTGATGCCCTGTCTTCCATCTTGCCAGAGGCCTTCAGCAATCTGCCGAATGACAGGCAGATGCTGTGCATCACA
GTGCTGCTCGGGCTGAATGACAGCAAGAATCGCTTAGTGAAAGCTGCAACTTCACGGGCCCTGGGAGTCTATGTGCTTTTTCCCTGTCTC
AGACAGGATGTCATATTTGTTGCAGACGCAGCAAATGCAATATTGATGTCACTTGAAGACAAGTCTCTGAATGTTCGAGCCAAAGCAGCC
TGGTCCCTGGGCAACCTGACAGACACTCTGATTGTCAACATGGAAACACCAGACCCAAGTTTCCAGGAAGAGTTCTCTGGTCTCCTGCTC
TTGAAAATGTTACGATCAGCTATAGAAGCATCCAAGGATAAAGACAAGGTAAAAAGCAATGCAGTCCGGGCCCTTGGAAATTTGCTTCAT
TTTCTGCAACCCTCTCATATAGAAAAACCCACATTTGCAGAAATCATTGAGGAGTCTATCCAGGCCCTAATTTCTACTGTTCTAACAGAA
GCTGCCATGAAAGTCCGATGGAATGCTTGTTATGCAATGGGAAATGTATTTAAAAATCCTGCCCTTCCTTTAGGGACAGCCCCATGGACC
TCCCAGGCCTACAATGCCCTGACATCGGTCGTGACATCATGCAAGAACTTCAAAGTGCGCATCAGATCTGCAGCTGCCCTTTCCGTCCCG
GGGAAGAGAGAGCAGTACGGGTCTGTTGACCAGTATGCTCGGATCTGGAATGCATTGGTCACCGCTTTACAGAAGAGTGAAGACACCATA
GACTTTTTGGAATTCAAGTACTGTGTCAGCCTACGGACCCAAATCTGCCAGGCACTGATTCACCTCTTGAGCTTGGCCAGTGCCTCGGAC
CTCCCTTGTATGAAAGAAACCCTTGAACTGAGTGGGAATATGGTCCAGTCCTATATTCTACAGTTTTTAAAATCAGGAGCAGAGGGAGAT
GACACTGGAGCACCCCACAGCCCACAGGAAAGAGACCAGATGGTCAGAATGGCCCTTAAACACATGGGCAGCATCCAGGCACCAACTGGA
GACACAGCCAGAAGGGCCATCATGGGCTTTTTAGAAGAGATCCTGGCCGTTTGTTTTGACTCATCTGGATCACAAGGGGCACTCCCAGGG
TTAACAAATCAGTGAAGATCCCACCATACTTTCTAGATGTCGAAGGCGGCAGTAGGAAGACCTGAGCTTGAGCATAAGATCTGTGGGATT
TCATCTTAGGGGCAGAAACAATCCGTTCACTATTTATTTAGAATGACTTAGCAGCCATTTAAATTTTCACAGAGGGCTCAACCACCTTTG
GAGTGACTCCATAGCACTGGCCATGGTCAGGGTTGTTGGAACATCTGACCTGTGCATCCAGGAGCCGAGGAGTCAGGTTGTAATACAGGC
CAAGCAGACGGGCTTTGAGGGCATTTAGTCTCAGAAAAAAAAAATGTAGAAGGATTTCGGAATTAGAATTTTGTGTATTGTATCTGTAGT

>5654_5654_1_APPBP2-HEATR6_APPBP2_chr17_58529241_ENST00000083182_HEATR6_chr17_58134764_ENST00000184956_length(amino acids)=1184AA_BP=1
MAGRCFLSHFLLGPASAAAVPQFAPGGGRAAVPSAVRPRGCHRPSESSGAAEGFATEGGGGLREEEAEEAEEEGRKMAAVELEWIPETLY
NTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRR
CSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMD
KLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKH
PKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLL
LASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLG
QEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWW
KKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVI
CKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNL
PNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPS
FQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNP
ALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALI
HLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFD

--------------------------------------------------------------
>5654_5654_2_APPBP2-HEATR6_APPBP2_chr17_58529241_ENST00000083182_HEATR6_chr17_58134764_ENST00000585976_length(transcript)=3350nt_BP=1792nt
GAGATCAGCGCTGGGACGGAACCCGGGTTCCTCTCGAACCGGGATTGTGACGCTTTTGGCCTGGCTGGCCGCTGTTTTCTGTCCCACTTT
TTACTCGGGCCTGCGTCCGCTGCCGCCGTCCCTCAGTTTGCCCCCGGAGGAGGCAGGGCGGCCGTGCCTTCTGCCGTGCGCCCGCGTGGC
TGCCACCGCCCCTCCGAATCCTCCGGGGCCGCAGAGGGGTTCGCTACGGAGGGAGGTGGGGGCCTTCGGGAGGAGGAGGCGGAGGAGGCG
GAGGAGGAGGGAAGGAAGATGGCGGCCGTGGAACTAGAGTGGATCCCAGAGACTCTCTATAACACCGCCATCTCCGCTGTCGTGGACAAC
TACATCCGCTCCCGCCGAGACATCCGCTCCTTGCCCGAGAACATCCAGTTTGATGTTTACTACAAGCTTTACCAACAGGGACGCTTATGT
CAACTGGGCAGTGAATTTTGTGAATTGGAAGTTTTTGCTAAAGTACTGAGAGCTTTGGATAAAAGACATTTGCTTCATCATTGTTTTCAG
GCTTTGATGGATCATGGTGTTAAAGTTGCTTCAGTCTTGGCCTACTCATTCAGTAGGCGGTGCTCTTATATAGCAGAATCAGATGCTGCA
GTAAAGGAAAAAGCCATTCAGGTTGGCTTTGTTTTAGGTGGCTTTCTTTCAGATGCAGGCTGGTACAGTGATGCTGAGAAAGTTTTTCTG
TCCTGCCTTCAGTTGTGTACTCTACACGATGAGATGCTTCATTGGTTTCGTGCAGTAGAATGTTGTGTGAGGTTGCTTCATGTGCGAAAT
GGAAACTGCAAATATCATTTGGGTGAAGAAACATTTAAATTAGCTCAGACATATATGGATAAACTATCAAAACATGGCCAGCAAGCAAAT
AAAGCTGCACTCTATGGAGAACTGTGTGCACTCCTATTTGCAAAAAGTCACTATGATGAGGCATACAAATGGTGCATCGAGGCAATGAAA
GAAATTACAGCAGGCTTACCAGTGAAAGTTGTGGTGGATGTCTTAAGACAAGCTTCTAAGGCTTGTGTAGTAAAACGTGAATTTAAGAAG
GCAGAACAGTTAATTAAACATGCAGTGTATTTGGCACGGGATCATTTTGGATCCAAACACCCAAAATATTCTGATACACTGCTAGATTAT
GGGTTCTACTTACTCAATGTAGATAATATCTGTCAGTCTGTTGCAATTTATCAGGCAGCCCTTGACATTAGACAGTCAGTGTTTGGTGGC
AAAAATATCCACGTAGCAACAGCTCATGAAGATTTGGCCTACTCTTCTTATGTCCACCAGTATAGCTCTGGGAAATTTGACAATGCACTA
TTTCATGCAGAAAGAGCTATTGGTATCATTACCCACATCCTACCTGAAGATCATCTTCTTTTGGCTTCTTCAAAGAGGGTGAAAGCACTT
ATTTTAGAGGAGATTGCAATTGATTGTCATAATAAGGAAACTGAACAGAGGCTGCTTCAAGAAGCTCATGATTTGCACCTGTCTTCACTC
CAACTAGCTAAAAAAGCTTTTGGGGAATTTAATGTACAGACTGCAAAACACTATGGAAACCTTGGAAGACTTTATCAGTCAATGAGAAAA
TTTAAGGAAGCTGAAGAAATGCACATCAAAGCAATTCAGATTAAAGAACAACTTCTTGGTCAAGAAGATTATGAAGTAGCCCTTTCAGTG
GGACATCTGGCTTCTTTATATAATTATGACATGAATCAGTATGAAAATGCTGAGAAACTTTATTTGCGATCTATAGCAATTGATGTTAAT
GTTCGTGTGTCAAGTCTCACACTCTTGGGAGCTATAGTGTCCACCCACGCACCTTTACCTGAAGTCCAACTACTTCTGCAACAGCCATGT
TCTTCTGGACTCGGTAATAGCAATTCAGCAACCCCTCACCTCAGCCCTCCTGATTGGTGGAAGAAAGCCCCTGCAGGACCCTCTCTGGAA
GAAACGTCAGTTAGCTCACCTAAGGGGTCTTCAGAGCCCTGCTGGCTCATTCGACTCTGCATTTCCATTGTCGTACTGCCCAAGGAGGAT
TCCTGTTCAGGTAGCGATGCTGGCTCTGCAGCAGGAAGCACCTACGAACCATCCCCCATGCGACTGGAGGCCTTCAGCAATCTGCCGAAT
GACAGGCAGATGCTGTGCATCACAGTGCTGCTCGGGCTGAATGACAGCAAGAATCGCTTAGTGAAAGCTGCAACTTCACGGGCCCTGGGA
GTCTATGTGCTTTTTCCCTGTCTCAGACAGGATGTCATATTTGTTGCAGACGCAGCAAATGCAATATTGATGTCACTTGAAGACAAGTCT
CTGAATGTTCGAGCCAAAGCAGCCTGGTCCCTGGGCAACCTGACAGACACTCTGATTGTCAACATGGAAACACCAGACCCAAGTTTCCAG
GAAGAGTTCTCTGGTCTCCTGCTCTTGAAAATGTTACGATCAGCTATAGAAGCATCCAAGGATAAAGACAAGGTAAAAAGCAATGCAGTC
CGGGCCCTTGGAAATTTGCTTCATTTTCTGCAACCCTCTCATATAGAAAAACCCACATTTGCAGAAATCATTGAGGAGTCTATCCAGGCC
CTAATTTCTACTGTTCTAACAGAAGCTGCCATGAAAGTCCGATGGAATGCTTGTTATGCAATGGGAAATGTATTTAAAAATCCTGCCCTT
CCTTTAGGGACAGCCCCATGGACCTCCCAGGCCTACAATGCCCTGACATCGGTCGTGACATCATGCAAGAACTTCAAAGTGCGCATCAGA
TCTGCAGCTGCCCTTTCCGTCCCGGGGAAGAGAGAGCAGTACGGGTCTGTTGACCAGTATGCTCGGATCTGGAATGCATTGGTCACCGCT
TTACAGAAGAGTGAAGACACCATAGACTTTTTGGAATTCAAGTACTGTGTCAGCCTACGGACCCAAATCTGCCAGGCACTGATTCACCTC
TTGAGCTTGGCCAGTGCCTCGGACCTCCCTTGTATGAAAGAAACCCTTGAACTGAGTGGGAATATGGTCCAGTCCTATATTCTACAGTTT
TTAAAATCAGGAGCAGAGGGAGATGACACTGGAGCACCCCACAGCCCACAGGAAAGAGACCAGATGGTCAGAATGGCCCTTAAACACATG
GGCAGCATCCAGGCACCAACTGGAGACACAGCCAGAAGGGCCATCATGGGCTTTTTAGAAGAGATCCTGGCCGTTTGTTTTGACTCATCT
GGATCACAAGGGGCACTCCCAGGGTTAACAAATCAGTGAAGATCCCACCATACTTTCTAGATGTCGAAGGCGGCAGTAGGAAGACCTGAG

>5654_5654_2_APPBP2-HEATR6_APPBP2_chr17_58529241_ENST00000083182_HEATR6_chr17_58134764_ENST00000585976_length(amino acids)=1072AA_BP=1
MAGRCFLSHFLLGPASAAAVPQFAPGGGRAAVPSAVRPRGCHRPSESSGAAEGFATEGGGGLREEEAEEAEEEGRKMAAVELEWIPETLY
NTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRR
CSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMD
KLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKH
PKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLL
LASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLG
QEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWW
KKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEAFSNLPNDRQMLCITVLLGLNDSKNRL
VKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASK
DKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVT
SCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSG

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Fusion Gene PPI Analysis for APPBP2-HEATR6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for APPBP2-HEATR6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for APPBP2-HEATR6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source