FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MYO10-LRRC28 (FusionGDB2 ID:56550)

Fusion Gene Summary for MYO10-LRRC28

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO10-LRRC28
Fusion gene ID: 56550
HgeneTgene
Gene symbol

MYO10

LRRC28

Gene ID

4651

123355

Gene namemyosin Xleucine rich repeat containing 28
Synonyms--
Cytomap

5p15.1

15q26.3

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-Xunconventional myosin-10unconventionnal myosin-Xleucine-rich repeat-containing protein 28
Modification date2020031320200313
UniProtAcc

Q9HD67

Q86X40

Ensembl transtripts involved in fusion geneENST00000513610, ENST00000274203, 
ENST00000427430, ENST00000505695, 
ENST00000507288, ENST00000512061, 
ENST00000515803, 		ENST00000331450, 
ENST00000442993, ENST00000447360, 
ENST00000559399, ENST00000422500, 
ENST00000558879, ENST00000301981, 
Fusion gene scores* DoF score20 X 14 X 10=280015 X 11 X 9=1485
# samples 2519
** MAII scorelog2(25/2800*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1485*10)=-2.96639160735718
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO10 [Title/Abstract] AND LRRC28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO10(16794755)-LRRC28(99926235), # samples:1
Anticipated loss of major functional domain due to fusion event.MYO10-LRRC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYO10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5734-11AMYO10chr5

16794755

-LRRC28chr15

99926235

+


Top

Fusion Gene ORF analysis for MYO10-LRRC28

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000513610ENST00000331450MYO10chr5

16794755

-LRRC28chr15

99926235

+
5CDS-intronENST00000513610ENST00000442993MYO10chr5

16794755

-LRRC28chr15

99926235

+
5CDS-intronENST00000513610ENST00000447360MYO10chr5

16794755

-LRRC28chr15

99926235

+
5CDS-intronENST00000513610ENST00000559399MYO10chr5

16794755

-LRRC28chr15

99926235

+
Frame-shiftENST00000513610ENST00000422500MYO10chr5

16794755

-LRRC28chr15

99926235

+
Frame-shiftENST00000513610ENST00000558879MYO10chr5

16794755

-LRRC28chr15

99926235

+
In-frameENST00000513610ENST00000301981MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000274203ENST00000301981MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000274203ENST00000422500MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000274203ENST00000558879MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000427430ENST00000301981MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000427430ENST00000422500MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000427430ENST00000558879MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000505695ENST00000301981MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000505695ENST00000422500MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000505695ENST00000558879MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000507288ENST00000301981MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000507288ENST00000422500MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000507288ENST00000558879MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000512061ENST00000301981MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000512061ENST00000422500MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000512061ENST00000558879MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000515803ENST00000301981MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000515803ENST00000422500MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-3CDSENST00000515803ENST00000558879MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000274203ENST00000331450MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000274203ENST00000442993MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000274203ENST00000447360MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000274203ENST00000559399MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000427430ENST00000331450MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000427430ENST00000442993MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000427430ENST00000447360MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000427430ENST00000559399MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000505695ENST00000331450MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000505695ENST00000442993MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000505695ENST00000447360MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000505695ENST00000559399MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000507288ENST00000331450MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000507288ENST00000442993MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000507288ENST00000447360MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000507288ENST00000559399MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000512061ENST00000331450MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000512061ENST00000442993MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000512061ENST00000447360MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000512061ENST00000559399MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000515803ENST00000331450MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000515803ENST00000442993MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000515803ENST00000447360MYO10chr5

16794755

-LRRC28chr15

99926235

+
intron-intronENST00000515803ENST00000559399MYO10chr5

16794755

-LRRC28chr15

99926235

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000513610MYO10chr516794755-ENST00000301981LRRC28chr1599926235+5622922401994197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000513610ENST00000301981MYO10chr516794755-LRRC28chr1599926235+0.0042139930.995786

Top

Fusion Genomic Features for MYO10-LRRC28


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MYO10-LRRC28


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:16794755/chr15:99926235)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO10

Q9HD67

LRRC28

Q86X40

FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-4411212_13101552059.0DomainPH 1
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-4411392_14971552059.0DomainPH 2
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-4411547_16951552059.0DomainMyTH4
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-4411700_20441552059.0DomainFERM
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-44163_7391552059.0DomainMyosin motor
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-441742_7631552059.0DomainIQ 1
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-441764_7871552059.0DomainIQ 2
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-441788_8171552059.0DomainIQ 3
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-441157_1641552059.0Nucleotide bindingATP
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-441619_6411552059.0RegionActin-binding
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-441815_9081552059.0RegionSAH
HgeneMYO10chr5:16794755chr15:99926235ENST00000513610-441883_9331552059.0RegionMediates antiparallel dimerization
TgeneLRRC28chr5:16794755chr15:99926235ENST00000301981810112_133343368.0RepeatNote=LRR 5
TgeneLRRC28chr5:16794755chr15:99926235ENST00000301981810135_156343368.0RepeatNote=LRR 6
TgeneLRRC28chr5:16794755chr15:99926235ENST00000301981810158_180343368.0RepeatNote=LRR 7
TgeneLRRC28chr5:16794755chr15:99926235ENST0000030198181016_36343368.0RepeatNote=LRR 1
TgeneLRRC28chr5:16794755chr15:99926235ENST00000301981810181_202343368.0RepeatNote=LRR 8
TgeneLRRC28chr5:16794755chr15:99926235ENST00000301981810204_226343368.0RepeatNote=LRR 9
TgeneLRRC28chr5:16794755chr15:99926235ENST0000030198181042_63343368.0RepeatNote=LRR 2
TgeneLRRC28chr5:16794755chr15:99926235ENST0000030198181066_87343368.0RepeatNote=LRR 3
TgeneLRRC28chr5:16794755chr15:99926235ENST0000030198181089_110343368.0RepeatNote=LRR 4
TgeneLRRC28chr5:16794755chr15:99926235ENST0000044736079112_133290313.0RepeatNote=LRR 5
TgeneLRRC28chr5:16794755chr15:99926235ENST0000044736079135_156290313.0RepeatNote=LRR 6
TgeneLRRC28chr5:16794755chr15:99926235ENST0000044736079158_180290313.0RepeatNote=LRR 7
TgeneLRRC28chr5:16794755chr15:99926235ENST000004473607916_36290313.0RepeatNote=LRR 1
TgeneLRRC28chr5:16794755chr15:99926235ENST0000044736079181_202290313.0RepeatNote=LRR 8
TgeneLRRC28chr5:16794755chr15:99926235ENST0000044736079204_226290313.0RepeatNote=LRR 9
TgeneLRRC28chr5:16794755chr15:99926235ENST000004473607942_63290313.0RepeatNote=LRR 2
TgeneLRRC28chr5:16794755chr15:99926235ENST000004473607966_87290313.0RepeatNote=LRR 3
TgeneLRRC28chr5:16794755chr15:99926235ENST000004473607989_110290313.0RepeatNote=LRR 4


Top

Fusion Gene Sequence for MYO10-LRRC28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56550_56550_1_MYO10-LRRC28_MYO10_chr5_16794755_ENST00000513610_LRRC28_chr15_99926235_ENST00000301981_length(transcript)=5622nt_BP=922nt
GCCGCGGCGCGGGACTGCTCACCTCCAAGCGCTCGCGCGGGGATCGCGGCTCCTGCTCACTTTGCGGCCCGCTGTCCTCCTGCCCGCCCC
GAGGGCCCCCGGCCGGAGCGCAGAGGGAGGGGGCCGCGCTCGCCAGCACCCCGCCGCCTTCCCCCGCCTGGGGGAAGAATGTGCCACCAG
CTGTTCTCCGCTTGCGAGCGCTGCGCCCAGTAGTGAGGAACTTGGAGGAAGAAGAGACAAAGGCTGCCGTCGGGACGGGCGAGTTAGGGA
CTTGGGTTTGGGCGAACAAAAGGTGAGAAGGACAAGAAGGGACCGGGCGATGGCAGCAGGGGAGCCCCGCGGGCGCGCGTCCTCGGGAGT
GGCGCCGTGACACGCATGGTTTCCCCGGACCCGCGGCGGCGCTGACTTCCGCGAGTCGGAGCGGCACTCGGCGAGTCCGGGACTGCGCTG
GAACAATGGATAACTTCTTCACCGAGGGAACACGGGTCTGGCTGAGAGAAAATGGCCAGCATTTTCCAAGTACTGTAAATTCCTGTGCAG
AAGGCATCGTCGTCTTCCGGACAGACTATGGTCAGGTATTCACTTACAAGCAGAGCACAATTACCCACCAGAAGGTGACTGCTATGCACC
CCACGAACGAGGAGGGCGTGGATGACATGGCGTCCTTGACAGAGCTCCATGGCGGCTCCATCATGTATAACTTATTCCAGCGGTATAAGA
GAAATCAAATATATACCTACATCGGCTCCATCCTGGCCTCCGTGAACCCCTACCAGCCCATCGCCGGGCTGTACGAGCCTGCCACCATGG
AGCAGTACAGCCGGCGCCACCTGGGCGAGCTGCCCCCGCACATCTTCGCCATCGCCAACGAGTGCTACCGCTGCCTGTGGAAGCGCCACG
ACAACCAGTGCATCCTCATCAGGAAGACAACTGTTAGTTTTGTGGCTTACTGCTGCTCCACCCAGTGTCTGCAGACTTTTGACCTGCTGA
GTTGATAAACACTCAAGAACCTCAGGAGCGCTGCCAGCTTGACACTGGGGAATCCAGCCAGTCCAGCACACTCTTCCATCCTGTCCTGTC
CAATGCGGGGGCACTGCAGAACTCTCTAGAAATGTCATGATTGAGCTTCAGAGCTAAAATGCCTTCACCCTTCCCCCAAGTTGGAATATA
TCCTCCCCCAAATTAAGGACCCATTTGTCTTCTGTGTTTTTCCTTTTTATGTGAGTGTGTCTTTTACAGAAACCATTTAGATTGATGGGC
CTCCCCAAATCTAATTTAAAGCAAGTTTCCGGTCCTTGGAGAACAGTGACTTGATCATCTAGCCAGATTCCCTTTTGAACACACATACCT
TCAGTGATGCTTCCTCTCCTCTCCCCTCCCTTGCTTTCCCCAGAGAGTTATTTCCCTGAGACCATGTTCTCCACAGTGTCTCCAGTGGAA
ACTTGTCAGTTTTTGAGGAGTTTCAGCAAACCCCGTGGCCTCAATGGTCTTGAGTAGCAGGGTGGGGCGCCTGAGTTGGCAGCAAAGTGA
GGCTCCCATGGAGGCTCAGTGAGGGTCCCAGAGCACACACCCTCTGGAAAGTTCCAGCCTTGTTTATACGTTCTACAGTGTAGCAACAGA
CTTTTGTGAGGGATTTTAAAAACAAAAATGTAGATTGTAATGAAATACACTTCCTGTTTTTTAAAAGTGTTTGCAGAAAAATGATTTTTG
AAGTTTTTAAATTTCCTGATAAGATTTTTTTTATATGAGAAGAATTTGAGGAATATTTGAAGCTTTACAAGATCTGATTTTTTTCTTTCT
CAATATAAAGTTTCCATACAATGAGAAAGGGGGAGAAAACACACATTGAAATAAGACCTCCGTGTTCTTTTTTGATGGGTTTATGATTCA
GTTTATACTGACTTTGAAATATTTTTGTCACATGTGAAAGGCTTCAGCTACTTCCACTACTGGTTTTTTTTTGTTGTTGTTGAGACGGAG
TCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTC
AGCCTCCCAAGTAGCTGGGACCACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTA
GCCGGGATGGTCTCGATCTCCTGACCTCGTGATCCGCACGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGG
CCCACTACTGGTTTTTAACAGGATGATTCAAAGTACAGCCCGTGCACATTTACTTCGTCACCTGGTGCACCACACTGTCTTCATGTTGGC
CCTCGTTTCTTGTATACTTAGCTTACTGCCCAGATGCAACTGAGAAAATACAGGAAAAGCAGGTCCAAATTCAGCCTTCGACTTCTGCAA
AAGTCCATAAACAGAAAGTCTGTGAGCCTCCACCCTGCCAGAAAGAACTCTTCATGAAGAAGTCACGTATTTGCTCTTCCTTTCAAAGGA
TGGCATTTTAATGTTGCTTTGCTGCCAGATGTTCATCTGCTTGCTGTGAAGTGATTCTTTTTTTAAAATGTTTTTTAATGATGTAAGTTT
TCTAAAAGGCAGGGCTGAATGGAGAACCAAGAATTTGCTTGGTAGAAAAATTATTTTTTTTTAATTTCAGACTTATCAAAAATTTGGTTG
AGGGAATTTTTATTAGCTGCCCTGACTTTATAATGCTACGCTCTTAACAGTGCCAAAAATCCTACATAGTTACTGACAAATGTGTGATCT
TTTTACAGTCACAACACCTGCTGCCCGGAAAGCACACCGTCCACGTAGAATGGAGAAGGCAGAAAGTTACCGTGTGTTCCCACTGTATCT
GCACTGTTCTTACTTCCTCTTGTCCCTTTTCATATCTTGGTCTATTCAGCCTTAACATTTCAAAGGCTTATAGTAAAATAGGAACTGAAG
ATCTGTATCAAAATGTAACACTTTCATCCTTTGGAATAATTGAAGTTTAACATAACCTCTACATGTATATAAGTTAGCTGGTGAAAATGT
GGCATGAAACTTCACAATTGTGCTTCAGGCCTAAGTGACTGCTACCTATGATTTAAGTGACAGTAAATGTCTTGCTACATTTTTCTATTT
CATCCTCTACAATCATATGTCATGGAATGGAGCTATGAAATGTGCTAACTTGGTATTCAGGATTCTCATTGTGATAAGGTGATACATTAG
TTTTACCTTGTTTGAAATTTTACAAAAATGCTTACAATCCAGGCATTCTTTCTCTACCTATTATGAACTACGGTGTGTTAAACAACAGCA
GTGGGCTGGGCAGACAACCTTTGGGCAGTCTCAACCTTAATCCTTGGGTACAGCACCTGAACTTAATTGATGAGAAGTGGAACTTAAGTG
GTTTCCCTGGTGCTGTTCATTATGGAAATTTTATGCTGGATTTATCGATGTCATTCTTAATCTTTTGATACTATAAAGGAGTCTTACCAA
CTGGAGAAAATTTGCCTACATGCTATATATTTGAATTGTGTCCAAAGCTTTGCAGAAAAGCAAATCTGAAGTTATTATATATGTTGTTTT
CTTGAGCAACAGTTACACTAGGTAGAAAAGTATTCACACAATAATAGTAATGCAAAAAAAGTGAGCTACTTGGAAAGTATCATCTCTGTT
CAGGTAAGTTTACTTCAGTGAACTCTTGTGTGGTTAGCGATAAGTTTTAAAGTCCAGGATAGCCTCATGAGCATAGGCCTTCCTATGAAG
TAGTGCAAAGGGGGCCGATTTTAGTGGATTACCCTATCAGTGTTCTTCAGTATGTCCAATTGTTATCATACCAAAAACCTTAATTACATA
ACATTGTGTGGATGAAATGCTGCATCTTCAGTTAATACATGTTTTGAGCACATTCTTAAAATACATAATAATTAAATGATCCCTATTCAA
AAGAACCCTGGCTTGGGTGGAGGATCCACTCTGGCTAACGGATAAGAGTGATGAACTTCTTTGTTACCTGACCCTTCTCTTCTGGAAAAG
TGAGGTGTACATTAAACATCTTTTGGTCACCGTGCCTCACTAAGACCTTTCACATTCCAGCTTGTCCGACTAGTGTAATGTACCTCTCAC
TTCTGTTTTACGTTGAGCATTACGAATTAAAATCTTTACAGTCTAGGGGGAAAAAAAGGCTTCAATACCAGTTGGCTTATGAGGCTCTGC
ATATAATTTTCTCTAAAATATGTAACTATTTTGTAGTCTGTGGGGACTTTCAAAGCCAATTTTTAAAATTAGTAGTAGTAAAGGTTTTTC
CCTTTCCTGAATGAAAAATCAGAAATTCTAATCTTTGCTATAAAGTACTTAAACACAATACATTGCCTCAGCATAAATAAAAACATTTTT
ATTAAGATGATTTATGAACATGGATTTCTAACTGGACCAACACTAATGTTGCAACCTGATAAAATTTGAGATGTAAATTCATTTCACAGA
CTCATAAACACACTCTCTTTAAGACTCTTCTTTAAATGGATCCTTACATTACCCTGCCTGTTTTATTATGCCTTCATTTTTGTGGTTTTC
ATTCACTCCTGCTTGCTTCTATTGAGGTTCTCCTACATTTCCCAGAAACTCAGTGAATATCTTGCCTTTTCTTCAAACAAAGGGGGTTTT
TATAAAGTTTGTATTTTTGAAACTAGCTCTATGTCTATCTAAAAATCAAGTCTCGGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGG
AGGCCGAGGAGGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAGCATGGTGAAACCCCATCTCTACTAAAAATACAAAAA
ATTAGCCAGGCGTGGTGGCGCGCACCTGCAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGCAGGAAGAGGTTG
CATTGAGCTGAGATCACGCCATTACACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAATCATTCAAGTTTCACTGTGCC
TACAGTGAGGAGCTACCTCCTTGTGTCATCAGCTAATAGATCTGAAAGTGATGCCGGTGTCTCTAGGAAAGGAATTGATCATAGCCAAGT
GACTGACATTCTCTCGGTCAGGAAAAGAGCTTGCTTCACAGCCTTTGAAGTATGACTGTATGTGTGGTCCCCTTGTACTTTGGAGACAGA
AGGTACTGGCAGCGAGTGTGGTGGATGGGCAGAAGGTGTAGCATTCGGAGATTATTTCTGTATGTAATTAAGAGACTTTCAAGGGTTAGC
CAGACTTTTTTCCACTCAAGTGTGGATTATCTTTGCTACCTGTGTTAAAGAATATCAGGTTTTGTTTCTTATTGTGATTTTTGAGTCTAA
ATGATCCAAGATTTTTAAAATAGATACATAATGAAATCCAGGCCTCTGAAAAATTATGGCAACATTCATTTGGAGTGTGGCTAAAAACTC
ATACTTTATCCAATTTGGTTGCCTCTCTCAGTTACTGCAGTTTATAGAATAATTGAGCTTGAACCATGTGAATGCTCAGAATGTCAATGG

>56550_56550_1_MYO10-LRRC28_MYO10_chr5_16794755_ENST00000513610_LRRC28_chr15_99926235_ENST00000301981_length(amino acids)=197AA_BP=173
MTSASRSGTRRVRDCAGTMDNFFTEGTRVWLRENGQHFPSTVNSCAEGIVVFRTDYGQVFTYKQSTITHQKVTAMHPTNEEGVDDMASLT
ELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILIRKTTVSF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MYO10-LRRC28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MYO10-LRRC28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MYO10-LRRC28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource