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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO10-RB1 (FusionGDB2 ID:56559)

Fusion Gene Summary for MYO10-RB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO10-RB1
Fusion gene ID: 56559
HgeneTgene
Gene symbol

MYO10

RB1

Gene ID

4651

5925

Gene namemyosin XRB transcriptional corepressor 1
Synonyms-OSRC|PPP1R130|RB|p105-Rb|p110-RB1|pRb|pp110
Cytomap

5p15.1

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-Xunconventional myosin-10unconventionnal myosin-Xretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas
Modification date2020031320200329
UniProtAcc

Q9HD67

RB1CC1

Ensembl transtripts involved in fusion geneENST00000274203, ENST00000427430, 
ENST00000505695, ENST00000513610, 
ENST00000515803, ENST00000507288, 
ENST00000512061, 		ENST00000484879, 
ENST00000267163, 
Fusion gene scores* DoF score20 X 14 X 10=280013 X 16 X 11=2288
# samples 2527
** MAII scorelog2(25/2800*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2288*10)=-3.08305573972756
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO10 [Title/Abstract] AND RB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO10(16689933)-RB1(48934153), # samples:1
Anticipated loss of major functional domain due to fusion event.MYO10-RB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MYO10-RB1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MYO10-RB1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MYO10-RB1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

TgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

TgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735


check buttonFusion gene breakpoints across MYO10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-JV-A5VF-01AMYO10chr5

16689933

-RB1chr13

48934153

+


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Fusion Gene ORF analysis for MYO10-RB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000274203ENST00000484879MYO10chr5

16689933

-RB1chr13

48934153

+
5CDS-intronENST00000427430ENST00000484879MYO10chr5

16689933

-RB1chr13

48934153

+
5CDS-intronENST00000505695ENST00000484879MYO10chr5

16689933

-RB1chr13

48934153

+
5CDS-intronENST00000513610ENST00000484879MYO10chr5

16689933

-RB1chr13

48934153

+
5CDS-intronENST00000515803ENST00000484879MYO10chr5

16689933

-RB1chr13

48934153

+
Frame-shiftENST00000427430ENST00000267163MYO10chr5

16689933

-RB1chr13

48934153

+
Frame-shiftENST00000505695ENST00000267163MYO10chr5

16689933

-RB1chr13

48934153

+
Frame-shiftENST00000513610ENST00000267163MYO10chr5

16689933

-RB1chr13

48934153

+
In-frameENST00000274203ENST00000267163MYO10chr5

16689933

-RB1chr13

48934153

+
In-frameENST00000515803ENST00000267163MYO10chr5

16689933

-RB1chr13

48934153

+
intron-3CDSENST00000507288ENST00000267163MYO10chr5

16689933

-RB1chr13

48934153

+
intron-3CDSENST00000512061ENST00000267163MYO10chr5

16689933

-RB1chr13

48934153

+
intron-intronENST00000507288ENST00000484879MYO10chr5

16689933

-RB1chr13

48934153

+
intron-intronENST00000512061ENST00000484879MYO10chr5

16689933

-RB1chr13

48934153

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274203MYO10chr516689933-ENST00000267163RB1chr1348934153+6314221921944398734
ENST00000515803MYO10chr516689933-ENST00000267163RB1chr1348934153+6341224622214425734

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274203ENST00000267163MYO10chr516689933-RB1chr1348934153+0.0007597720.9992403
ENST00000515803ENST00000267163MYO10chr516689933-RB1chr1348934153+0.0007860860.99921393

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Fusion Genomic Features for MYO10-RB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYO10-RB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:16689933/chr13:48934153)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO10

Q9HD67

RB1

RB1CC1

FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250}.1594

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-284163_73912982059.0DomainMyosin motor
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-2841742_76312982059.0DomainIQ 1
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-2841764_78712982059.0DomainIQ 2
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-2841788_81712982059.0DomainIQ 3
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-2841157_16412982059.0Nucleotide bindingATP
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-2841619_64112982059.0RegionActin-binding
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-2841815_90812982059.0RegionSAH
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-2841883_93312982059.0RegionMediates antiparallel dimerization
TgeneRB1chr5:16689933chr13:48934153ENST00000267163527860_876202929.0MotifBipartite nuclear localization signal
TgeneRB1chr5:16689933chr13:48934153ENST00000267163527373_579202929.0RegionNote=Domain A
TgeneRB1chr5:16689933chr13:48934153ENST00000267163527373_771202929.0RegionNote=Pocket%3B binds T and E1A
TgeneRB1chr5:16689933chr13:48934153ENST00000267163527580_639202929.0RegionNote=Spacer
TgeneRB1chr5:16689933chr13:48934153ENST00000267163527640_771202929.0RegionNote=Domain B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-28411212_131012982059.0DomainPH 1
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-28411392_149712982059.0DomainPH 2
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-28411547_169512982059.0DomainMyTH4
HgeneMYO10chr5:16689933chr13:48934153ENST00000513610-28411700_204412982059.0DomainFERM
TgeneRB1chr5:16689933chr13:48934153ENST0000026716352710_18202929.0Compositional biasNote=Poly-Ala
TgeneRB1chr5:16689933chr13:48934153ENST0000026716352720_29202929.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for MYO10-RB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56559_56559_1_MYO10-RB1_MYO10_chr5_16689933_ENST00000274203_RB1_chr13_48934153_ENST00000267163_length(transcript)=6314nt_BP=2219nt
TGCACTTGCTACCCTTCTGCAGGAAGCTTCCCAGCCAGCACAGTTTCTCTCTGCCCTGCCTCTTAATCCCCACCCCTGCTCCCAGGCCTG
GGACACTGCTAACCACCCCTCCTTCCTGACACCTCTCTGACCACCCCTCCTCCTCTTGACTGGTTCCTCTGGAGGTAGGCATGGCCTCGG
GTTCTGCCCCCAGTTTCTCACTCGCTGGGCTCCAAAAGAAACACTGGCTTCTCTCCTTCAGCTCCAGGCTAGATGCCAGACCAGTTTGAC
CAGGCGGTTGTGCTGAACCAGCTGCGGTACTCAGGGATGCTGGAGACTGTGAGAATCCGCAAAGCTGGGTATGCGGTCCGAAGACCCTTT
CAGGACTTTTACAAAAGGTATAAAGTGCTGATGAGGAATCTGGCTCTGCCTGAGGACGTCCGAGGGAAGTGCACGAGCCTGCTGCAGCTC
TATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAAGACCAAGGTCTTTCTTCGAGAATCCTTGGAACAGAAACTGGAGAAGCGGAGGGAA
GAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGCCCATGTCTTGGGCTTCTTAGCACGAAAACAATACAGAAAGGTCCTTTATTGTGTG
GTGATAATACAGAAGAATTACAGAGCATTCCTTCTGAGGAGGAGATTTTTGCACCTGAAAAAGGCAGCCATAGTTTTCCAGAAGCAACTC
AGAGGTCAGATTGCTCGGAGAGTTTACAGACAATTGCTGGCAGAGAAAAGGGAGCAAGAAGAAAAGAAGAAACAGGAAGAGGAAGAAAAG
AAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAGAGAGCGAAGAGAAGCCGAGCTCCGCGCCCAGCAGGAAGAAGAAACGAGGAAGCAG
CAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGAAGCTGAACTGACCCGTGAACTGGAGAAACAGAAGGAAAATAAGCAGGTGGAAGAG
ATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCAGCGCATGAAGGAGCAGCAGGAGCTGTCGCTGACCGAGGCTTCCCTGCAGAAGCTG
CAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGAGGAGGAAGCGTGCAGGGCGGCCCAGGAGTTCCTCGAGTCCCTCAATTTCGACGAG
ATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCTGTCGGTGGGAAGCGAATTTTCCAGCGAGCTGGCTGAGAGCGCATGCGAGGAGAAG
CCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGAGGAGGTCGATGAGGGCTTCGAAGCCGACGACGACGCCTTCAAGGACTCCCCCAAC
CCCAGCGAGCACGGCCACTCAGACCAGCGAACAAGTGGCATCCGGACCAGCGATGACTCTTCAGAGGAGGACCCATACATGAACGACACG
GTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGTGCTGCTCGCCCCATCAGTGCAGGACTCCGGGAGCCTACACAACTCCTCCAGCGGC
GAGTCCACCTACTGCATGCCCCAGAACGCTGGGGACTTGCCCTCCCCAGACGGCGACTACGACTACGACCAGGATGACTATGAGGACGGT
GCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAACTCCTACGGCAGCCAGTGGTCCCCCGACTACCGCTGCTCTGTGGGGACCTACAAC
AGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGCGCAGTCCTCGTTTGAAGATAGTGAAGAGGACTTTGATTCCAGGTTTGATACAGAT
GATGAGCTTTCATACCGGCGTGACTCTGTGTACAGCTGTGTCACTCTGCCGTATTTCCACAGCTTTCTGTACATGAAAGGTGGCCTGATG
AACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGATGAAACCTTCTTGTGGTTCCGCTCCAAGCAGGAGGCCCTCAAGCAAGGCTGGCTC
CACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAGGAGAAATTGGAAGAAGCGCTGGTTTGTCCTCCGCCAGTCCAAGCTGATGTACTTT
GAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGTAGAAGTGCGAACGGCAAAAGAGATCATAGATAACACCACCAAGGAGAATGGGATC
GACATCATTATGGCCGATAGGACTTTCCACCTGATTGCAGAGTCCCCAGAAGATGCCAGGGGAAGTATTACAAATGGAAGATGATCTGGT
GATTTCATTTCAGTTAATGCTATGTGTCCTTGACTATTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGAACCATATAAAACAGCTGT
TATACCCATTAATGGTTCACCTCGAACACCCAGGCGAGGTCAGAACAGGAGTGCACGGATAGCAAAACAACTAGAAAATGATACAAGAAT
TATTGAAGTTCTCTGTAAAGAACATGAATGTAATATAGATGAGGTGAAAAATGTTTATTTCAAAAATTTTATACCTTTTATGAATTCTCT
TGGACTTGTAACATCTAATGGACTTCCAGAGGTTGAAAATCTTTCTAAACGATACGAAGAAATTTATCTTAAAAATAAAGATCTAGATGC
AAGATTATTTTTGGATCATGATAAAACTCTTCAGACTGATTCTATAGACAGTTTTGAAACACAGAGAACACCACGAAAAAGTAACCTTGA
TGAAGAGGTGAATGTAATTCCTCCACACACTCCAGTTAGGACTGTTATGAACACTATCCAACAATTAATGATGATTTTAAATTCAGCAAG
TGATCAACCTTCAGAAAATCTGATTTCCTATTTTAACAACTGCACAGTGAATCCAAAAGAAAGTATACTGAAAAGAGTGAAGGATATAGG
ATACATCTTTAAAGAGAAATTTGCTAAAGCTGTGGGACAGGGTTGTGTCGAAATTGGATCACAGCGATACAAACTTGGAGTTCGCTTGTA
TTACCGAGTAATGGAATCCATGCTTAAATCAGAAGAAGAACGATTATCCATTCAAAATTTTAGCAAACTTCTGAATGACAACATTTTTCA
TATGTCTTTATTGGCGTGCGCTCTTGAGGTTGTAATGGCCACATATAGCAGAAGTACATCTCAGAATCTTGATTCTGGAACAGATTTGTC
TTTCCCATGGATTCTGAATGTGCTTAATTTAAAAGCCTTTGATTTTTACAAAGTGATCGAAAGTTTTATCAAAGCAGAAGGCAACTTGAC
AAGAGAAATGATAAAACATTTAGAACGATGTGAACATCGAATCATGGAATCCCTTGCATGGCTCTCAGATTCACCTTTATTTGATCTTAT
TAAACAATCAAAGGACCGAGAAGGACCAACTGATCACCTTGAATCTGCTTGTCCTCTTAATCTTCCTCTCCAGAATAATCACACTGCAGC
AGATATGTATCTTTCTCCTGTAAGATCTCCAAAGAAAAAAGGTTCAACTACGCGTGTAAATTCTACTGCAAATGCAGAGACACAAGCAAC
CTCAGCCTTCCAGACCCAGAAGCCATTGAAATCTACCTCTCTTTCACTGTTTTATAAAAAAGTGTATCGGCTAGCCTATCTCCGGCTAAA
TACACTTTGTGAACGCCTTCTGTCTGAGCACCCAGAATTAGAACATATCATCTGGACCCTTTTCCAGCACACCCTGCAGAATGAGTATGA
ACTCATGAGAGACAGGCATTTGGACCAAATTATGATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAAT
CATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTAT
AGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACC
TCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATA
TAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGA
GAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAA
AAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGA
AATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGA
CCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTT
AATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTAT
TTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTT
ATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGT
TTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCA
ATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTA
CACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCA
AAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAAC
TTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGA
AAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAG
AATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCAT
CTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAAT
TGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAA
TCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCG
CTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATAT
TTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAA
ATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCAT
CATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTA
GAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTT
GTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAG
AGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTAGGAGAAGATAGATAGAAGATAACTCTC

>56559_56559_1_MYO10-RB1_MYO10_chr5_16689933_ENST00000274203_RB1_chr13_48934153_ENST00000267163_length(amino acids)=734AA_BP=8
MQSPQKMPGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECN
IDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTP
VRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSE
EERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCE
HRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKS
TSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHA
VQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTK
MTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQ

--------------------------------------------------------------
>56559_56559_2_MYO10-RB1_MYO10_chr5_16689933_ENST00000515803_RB1_chr13_48934153_ENST00000267163_length(transcript)=6341nt_BP=2246nt
TTCTTTCTAATGCCAGGCAATCAAGGCTGCACTTGCTACCCTTCTGCAGGAAGCTTCCCAGCCAGCACAGTTTCTCTCTGCCCTGCCTCT
TAATCCCCACCCCTGCTCCCAGGCCTGGGACACTGCTAACCACCCCTCCTTCCTGACACCTCTCTGACCACCCCTCCTCCTCTTGACTGG
TTCCTCTGGAGGTAGGCATGGCCTCGGGTTCTGCCCCCAGTTTCTCACTCGCTGGGCTCCAAAAGAAACACTGGCTTCTCTCCTTCAGCT
CCAGGCTAGATGCCAGACCAGTTTGACCAGGCGGTTGTGCTGAACCAGCTGCGGTACTCAGGGATGCTGGAGACTGTGAGAATCCGCAAA
GCTGGGTATGCGGTCCGAAGACCCTTTCAGGACTTTTACAAAAGGTATAAAGTGCTGATGAGGAATCTGGCTCTGCCTGAGGACGTCCGA
GGGAAGTGCACGAGCCTGCTGCAGCTCTATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAAGACCAAGGTCTTTCTTCGAGAATCCTTG
GAACAGAAACTGGAGAAGCGGAGGGAAGAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGCCCATGTCTTGGGCTTCTTAGCACGAAAA
CAATACAGAAAGGTCCTTTATTGTGTGGTGATAATACAGAAGAATTACAGAGCATTCCTTCTGAGGAGGAGATTTTTGCACCTGAAAAAG
GCAGCCATAGTTTTCCAGAAGCAACTCAGAGGTCAGATTGCTCGGAGAGTTTACAGACAATTGCTGGCAGAGAAAAGGGAGCAAGAAGAA
AAGAAGAAACAGGAAGAGGAAGAAAAGAAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAGAGAGCGAAGAGAAGCCGAGCTCCGCGCC
CAGCAGGAAGAAGAAACGAGGAAGCAGCAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGAAGCTGAACTGACCCGTGAACTGGAGAAA
CAGAAGGAAAATAAGCAGGTGGAAGAGATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCAGCGCATGAAGGAGCAGCAGGAGCTGTCG
CTGACCGAGGCTTCCCTGCAGAAGCTGCAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGAGGAGGAAGCGTGCAGGGCGGCCCAGGAG
TTCCTCGAGTCCCTCAATTTCGACGAGATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCTGTCGGTGGGAAGCGAATTTTCCAGCGAG
CTGGCTGAGAGCGCATGCGAGGAGAAGCCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGAGGAGGTCGATGAGGGCTTCGAAGCCGAC
GACGACGCCTTCAAGGACTCCCCCAACCCCAGCGAGCACGGCCACTCAGACCAGCGAACAAGTGGCATCCGGACCAGCGATGACTCTTCA
GAGGAGGACCCATACATGAACGACACGGTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGTGCTGCTCGCCCCATCAGTGCAGGACTCC
GGGAGCCTACACAACTCCTCCAGCGGCGAGTCCACCTACTGCATGCCCCAGAACGCTGGGGACTTGCCCTCCCCAGACGGCGACTACGAC
TACGACCAGGATGACTATGAGGACGGTGCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAACTCCTACGGCAGCCAGTGGTCCCCCGAC
TACCGCTGCTCTGTGGGGACCTACAACAGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGCGCAGTCCTCGTTTGAAGATAGTGAAGAG
GACTTTGATTCCAGGTTTGATACAGATGATGAGCTTTCATACCGGCGTGACTCTGTGTACAGCTGTGTCACTCTGCCGTATTTCCACAGC
TTTCTGTACATGAAAGGTGGCCTGATGAACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGATGAAACCTTCTTGTGGTTCCGCTCCAAG
CAGGAGGCCCTCAAGCAAGGCTGGCTCCACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAGGAGAAATTGGAAGAAGCGCTGGTTTGTC
CTCCGCCAGTCCAAGCTGATGTACTTTGAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGTAGAAGTGCGAACGGCAAAAGAGATCATA
GATAACACCACCAAGGAGAATGGGATCGACATCATTATGGCCGATAGGACTTTCCACCTGATTGCAGAGTCCCCAGAAGATGCCAGGGGA
AGTATTACAAATGGAAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGACTATTTTATTAAACTCTCACCTCCCATGTT
GCTCAAAGAACCATATAAAACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGGCGAGGTCAGAACAGGAGTGCACGGATAGC
AAAACAACTAGAAAATGATACAAGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAATATAGATGAGGTGAAAAATGTTTATTTCAA
AAATTTTATACCTTTTATGAATTCTCTTGGACTTGTAACATCTAATGGACTTCCAGAGGTTGAAAATCTTTCTAAACGATACGAAGAAAT
TTATCTTAAAAATAAAGATCTAGATGCAAGATTATTTTTGGATCATGATAAAACTCTTCAGACTGATTCTATAGACAGTTTTGAAACACA
GAGAACACCACGAAAAAGTAACCTTGATGAAGAGGTGAATGTAATTCCTCCACACACTCCAGTTAGGACTGTTATGAACACTATCCAACA
ATTAATGATGATTTTAAATTCAGCAAGTGATCAACCTTCAGAAAATCTGATTTCCTATTTTAACAACTGCACAGTGAATCCAAAAGAAAG
TATACTGAAAAGAGTGAAGGATATAGGATACATCTTTAAAGAGAAATTTGCTAAAGCTGTGGGACAGGGTTGTGTCGAAATTGGATCACA
GCGATACAAACTTGGAGTTCGCTTGTATTACCGAGTAATGGAATCCATGCTTAAATCAGAAGAAGAACGATTATCCATTCAAAATTTTAG
CAAACTTCTGAATGACAACATTTTTCATATGTCTTTATTGGCGTGCGCTCTTGAGGTTGTAATGGCCACATATAGCAGAAGTACATCTCA
GAATCTTGATTCTGGAACAGATTTGTCTTTCCCATGGATTCTGAATGTGCTTAATTTAAAAGCCTTTGATTTTTACAAAGTGATCGAAAG
TTTTATCAAAGCAGAAGGCAACTTGACAAGAGAAATGATAAAACATTTAGAACGATGTGAACATCGAATCATGGAATCCCTTGCATGGCT
CTCAGATTCACCTTTATTTGATCTTATTAAACAATCAAAGGACCGAGAAGGACCAACTGATCACCTTGAATCTGCTTGTCCTCTTAATCT
TCCTCTCCAGAATAATCACACTGCAGCAGATATGTATCTTTCTCCTGTAAGATCTCCAAAGAAAAAAGGTTCAACTACGCGTGTAAATTC
TACTGCAAATGCAGAGACACAAGCAACCTCAGCCTTCCAGACCCAGAAGCCATTGAAATCTACCTCTCTTTCACTGTTTTATAAAAAAGT
GTATCGGCTAGCCTATCTCCGGCTAAATACACTTTGTGAACGCCTTCTGTCTGAGCACCCAGAATTAGAACATATCATCTGGACCCTTTT
CCAGCACACCCTGCAGAATGAGTATGAACTCATGAGAGACAGGCATTTGGACCAAATTATGATGTGTTCCATGTATGGCATATGCAAAGT
GAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGAT
CAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCAC
CAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACAT
CTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATC
AATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGA
AGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGA
GTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAA
CAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTT
TCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAA
GCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCC
TCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTG
CCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAA
ATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTA
GAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTG
CTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGA
ACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAA
TTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGC
ACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTT
TTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGT
CTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACA
TTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATT
AAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGA
GATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAA
AGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATG
ACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCT
GGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTT
CAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGT
CTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTA

>56559_56559_2_MYO10-RB1_MYO10_chr5_16689933_ENST00000515803_RB1_chr13_48934153_ENST00000267163_length(amino acids)=734AA_BP=8
MQSPQKMPGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECN
IDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTP
VRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSE
EERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCE
HRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKS
TSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHA
VQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTK
MTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQ

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Fusion Gene PPI Analysis for MYO10-RB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRB1chr5:16689933chr13:48934153ENST00000267163527763_928202.33333333333334929.0LIMD1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO10-RB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO10-RB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource