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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MYO10-ST6GALNAC3 (FusionGDB2 ID:56562)

Fusion Gene Summary for MYO10-ST6GALNAC3

Fusion gene summary

Fusion gene information	Fusion gene name: MYO10-ST6GALNAC3
	Fusion gene ID: 56562
		Hgene	Tgene
	Gene symbol	MYO10	ST6GALNAC3
	Gene ID	4651	256435
	Gene name	myosin X	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
	Synonyms	-	PRO7177\|SIAT7C\|ST6GALNACIII\|STY
	Cytomap	5p15.1	1p31.1
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-Xunconventional myosin-10unconventionnal myosin-X	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3GalNAc alpha-2,6-sialyltransferase IIIST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltranST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)
	Modification date	20200313	20200313
	UniProtAcc	Q9HD67	.
	Ensembl transtripts involved in fusion gene	ENST00000507288, ENST00000513610, ENST00000274203, ENST00000427430, ENST00000505695, ENST00000512061, ENST00000515803,	ENST00000464140, ENST00000328299,
Fusion gene scores	* DoF score	20 X 14 X 10=2800	7 X 7 X 3=147
	# samples	25	7
	** MAII score	log2(25/2800*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MYO10 [Title/Abstract] AND ST6GALNAC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MYO10(16935897)-ST6GALNAC3(76779490), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ST6GALNAC3	GO:0006677	glycosylceramide metabolic process	17123352
Tgene	ST6GALNAC3	GO:0006687	glycosphingolipid metabolic process	17123352
Tgene	ST6GALNAC3	GO:0009100	glycoprotein metabolic process	17123352

Fusion gene breakpoints across MYO10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ST6GALNAC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-05-4424-01A	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+

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Fusion Gene ORF analysis for MYO10-ST6GALNAC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000507288	ENST00000464140	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
5CDS-intron	ENST00000513610	ENST00000464140	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
In-frame	ENST00000507288	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
In-frame	ENST00000513610	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-3CDS	ENST00000274203	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-3CDS	ENST00000427430	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-3CDS	ENST00000505695	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-3CDS	ENST00000512061	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-3CDS	ENST00000515803	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-intron	ENST00000274203	ENST00000464140	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-intron	ENST00000427430	ENST00000464140	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-intron	ENST00000505695	ENST00000464140	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-intron	ENST00000512061	ENST00000464140	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+
intron-intron	ENST00000515803	ENST00000464140	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000513610

MYO10

chr5

16935897

ENST00000328299

ST6GALNAC3

chr1

76779490

7171

476

401

1375

324

ENST00000507288

MYO10

chr5

16935897

ENST00000328299

ST6GALNAC3

chr1

76779490

7167

472

397

1371

324

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000513610	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+	0.000452015	0.999548
ENST00000507288	ENST00000328299	MYO10	chr5	16935897	-	ST6GALNAC3	chr1	76779490	+	0.00045158	0.9995484

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Fusion Genomic Features for MYO10-ST6GALNAC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO10-ST6GALNAC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:16935897/chr1:76779490)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYO10 Q9HD67	.
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269\|PubMed:16894163, ECO:0000269\|PubMed:18570893}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ST6GALNAC3

chr5:16935897

chr1:76779490

ENST00000328299

29_305

306.0

Topological domain

Lumenal

Tgene

ST6GALNAC3

chr5:16935897

chr1:76779490

ENST00000328299

9_28

306.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

1212_1310

2059.0

Domain

PH 1

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

1392_1497

2059.0

Domain

PH 2

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

1547_1695

2059.0

Domain

MyTH4

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

1700_2044

2059.0

Domain

FERM

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

63_739

2059.0

Domain

Myosin motor

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

742_763

2059.0

Domain

IQ 1

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

764_787

2059.0

Domain

IQ 2

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

788_817

2059.0

Domain

IQ 3

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

157_164

2059.0

Nucleotide binding

ATP

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

619_641

2059.0

Region

Actin-binding

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

815_908

2059.0

Region

SAH

Hgene

MYO10

chr5:16935897

chr1:76779490

ENST00000513610

883_933

2059.0

Region

Mediates antiparallel dimerization

Tgene

ST6GALNAC3

chr5:16935897

chr1:76779490

ENST00000328299

1_8

306.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for MYO10-ST6GALNAC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>56562_56562_1_MYO10-ST6GALNAC3_MYO10_chr5_16935897_ENST00000507288_ST6GALNAC3_chr1_76779490_ENST00000328299_length(transcript)=7167nt_BP=472nt
CGGCGCGGGACTGCTCACCTCCAAGCGCTCGCGCGGGGATCGCGGCTCCTGCTCACTTTGCGGCCCGCTGTCCTCCTGCCCGCCCCGAGG
GCCCCCGGCCGGAGCGCAGAGGGAGGGGGCCGCGCTCGCCAGCACCCCGCCGCCTTCCCCCGCCTGGGGGAAGAATGTGCCACCAGCTGT
TCTCCGCTTGCGAGCGCTGCGCCCAGTAGTGAGGAACTTGGAGGAAGAAGAGACAAAGGCTGCCGTCGGGACGGGCGAGTTAGGGACTTG
GGTTTGGGCGAACAAAAGGTGAGAAGGACAAGAAGGGACCGGGCGATGGCAGCAGGGGAGCCCCGCGGGCGCGCGTCCTCGGGAGTGGCG
CCGTGACACGCATGGTTTCCCCGGACCCGCGGCGGCGCTGACTTCCGCGAGTCGGAGCGGCACTCGGCGAGTCCGGGACTGCGCTGGAAC
AATGGATAACTTCTTCACCGAGAGAAAGTCTGTGATTGCTGTGAGCTTCATAGCAGCGTTCCTTTTCCTGCTGGTTGTGCGTCTTGTAAA
TGAAGTGAATTTCCCATTGCTACTAAACTGCTTTGGACAACCTGGTACAAAGTGGATACCATTCTCCTACACATACAGGCGGCCCCTTCG
AACTCACTATGGATACATAAATGTGAAGACACAAGAGCCTTTGCAACTGGACTGTGACCTTTGTGCCATAGTGTCAAACTCAGGTCAGAT
GGTTGGCCAGAAGGTGGGAAATGAGATAGATCGATCCTCCTGCATTTGGAGAATGAACAATGCCCCCACCAAAGGTTATGAAGAAGATGT
CGGCCGCATGACCATGATTCGAGTTGTGTCCCATACCAGCGTTCCTCTTTTGCTAAAAAACCCTGATTATTTTTTCAAGGAAGCGAATAC
TACTATTTATGTTATTTGGGGACCTTTCCGCAATATGAGGAAAGATGGCAATGGCATCGTTTACAACATGTTGAAAAAGACAGTTGGTAT
CTATCCGAATGCCCAAATATACGTGACCACAGAGAAGCGCATGAGTTACTGTGATGGAGTTTTTAAGAAGGAAACTGGGAAGGACAGAGT
CCAGTCTGGCTCATATCTCAGCACAGGGTGGTTTACCTTCCTTCTGGCCATGGACGCCTGTTATGGCATTCACGTCTACGGGATGATAAA
TGACACCTACTGCAAGACAGAAGGGTATAGAAAAGTCCCCTACCATTATTATGAACAAGGAAGAGATGAGTGTGATGAATATTTTCTTCA
TGAACATGCCCCATATGGGGGTCATAGGTTTATCACTGAAAAGAAAGTGTTTGCTAAATGGGCCAAGAAGCACAGGATAATATTTACACA
TCCAAACTGGACATTGTCTTGATAATGGTTTTCCTGATCTTGCCGCATCACTTAATGTGATCCCCATACTGCAACTGTGATGCTGATGAT
GCTAATGGAGATGATGGTAATGATAAAGACAACAACAATGATTATCAAGTTCCTGTACACTCTCAGATGTGGATGGTGACTCTGCTAGTA
ATTTAAACTTGGCATTTCATGGAGGATGGTTGTGCTCATGATGTTCTTTCTGGAGGTTCAACACTACGTACCGCACTTTATAATTTAACT
GGAATTGAGATGAAGGCCAGTGACATGACAACTGTGACCTAAGAAATGGGAAGATTATCTTTCAAGATAGCTGCCTAGAATTGTTCAACA
GTGAGTAACTTCCAGAAGCCAAAAGAGTTTGGCTTCATGAGGCAAGGTGATTGACTCAATGGCTTGTTGAATCTCAGCAGTTCCGCCATC
TTGAAGAATGATTGATTGTCAAACACTGACCCAAGAACTGCTATCAGGGTGCAAGTATCTTACTACTTAGCCTAAGGATGGGAAAATATC
TCTTCCTAATATACCATCTTTCTACAGTATTTCCTACAGCTAAAGCCTCAGGCCATTGCCTAATTAACAATGAAGATTTCATGGACATCC
TACACTTCAGGATTACTTGACTATCTCAAACACATAAATCAAAATGGGCCAAGTAGCAAATCTTGATGAATTTCCACTCTTACCATCCAT
TCTTACTACCAACAGTATAACTGAACATGTGATTAGAATGATCTATATTAATGTTTAGTTATTTTTGGTTGAGTGCTAAATATTTCAGAA
GGCTACTTAACATGTAAGATACCAACTTCAACACTGTAATAACATATACTGTGAAAACATTCCTAAAAAGTAACCAAAGGGTTTGCTAAC
TCTGCTTCAACATCCAACAACACAAAACTATATGATTTTTAAAATCATGAAATAGAGACAGCAAAGCATATTTTTACATCAATTTGTATC
CTATCATACTTCATAATATATATTTGTATATTCAAATTTCTATTTTATAGGCCCAAGGTGTGTTTCTCCAAACATTACATTCTCATTGCC
AAGTGCCAGCTGTTACACATGGAGAGGAAATGATTCCTTATATTAAACCTGACCAGAGCTTTTTGCCTTCTAGGGATTTATTTTTCCCAT
AGTGTATCAGTTGTTATGCCACAATAACAACAATAATAATGTTCTTAATGTCCAAAGTGCTTTGTCATTTAGAGTCCTTTAACATCTGTT
ATACCATGTGATGCCCTTGAACACCCCATTGGGCTATTGTCTGTGTATTCTGCTCTCTTTAGCAGATGATCTGTAATTTGGTCATTGTTC
TGTTATATTCCAGATTGCTCTACTTGCTAATATTTGTATAGAATAGAATTTATGTAAACTAGTAACCAGTTGATCTCTGTGCCAAATACA
TTATATCAGGATTACACAAAAAGTATCACAAAGGATGGTCTTGGCCATATGCTAGGGCCCCTGTGAAAATAAGTAGTTTTGAGAAGTTTT
TCTATATACGTATATATACACGTGTGGTTCTATTTAGGTGGGGAAAAAATGAAAAAGCAGGGACAACAGGAGGAAATGAAGGCAGAGAAA
TATAGTTTCCTTTCCTAGGATTGAGACAATTCTATTTTTCATATACTCGTTGCTCATTAAATAGTAAAGGGTTGATTTGCTGCAAGAGTA
GCTGAGAATTCAAAAACATCCTTGCAGAATGATTCAAAAGACAAAAGCCAGGCTCAACTTATAGAATGTTTTGGAAACTGGAAGTAATGA
TACATTTCACTTCAGAAGCACTTGTAGGTCTTTACTAGTGCTAAGTATTATGGTGAGCTATCATTAAAGTGTGCCATCTTGGATAAAGGC
CTTTTGCCTACTCTCTTCTGCAATTTTGACACCTCAATATTCACACCCATAAACATTACTAAGCCCCAGTTCTATCGTTGGAAGGAGTTG
TTATTCTTTTGTTGTTCCCTTATGCAATTTTTAATTCTATGAATGTTAAGTTTTTTTGAGCTAATGATAGATAGAAATGCCCACTCAAAG
AAAAATAAACAGAGACAAATGTTAAAATTGCCATACAGACTGTTTTTCCCCCTGTTGTTTCACTTTAAAATAAAAAGAAATCCTTGATTA
ATCAGAATGGCTTGGGACATGAACTTAATTTATTTAGTTTTCTAATAAATGAAGGGCCAACTCTTATTTGTTCTAGCCCCTACTGATGAG
AAACATTTGAAAACTTGCTTGCTCTCCTGCCTCGTTGTAGCTTTCTCTGATGAAGACTTCTGCAGTATATTGTATCCCTCACTCTATAGC
AGAAGGTGTGTGTGGAATATGTAGACTCCAGTGTTTTCTTAGGAGGGGTGGGAAAGGGCTTTCTTTCCTCTCCTCTCCTCTCGTCTCCTC
TTTCTTTCCTTTCTTTTTGCAACTAAACTGCTACTCTACACTTTTTATTGTTGTTTTCTTTGTCTTTTTCTTTCTACAAACAGGAAACAA
AAAAAAAAAAAAACAAGTTTTTCTCAATTTGGAGACTCAATTGAATAATTTCCAGTATAATCAGCATTTTGATAGAATCTCACAACTTAT
TTTTCTCTGCTTTTATTTCCTGTTTTTCTTTGTTCCATCTTTCTAATTCTAGTGAAAATGCAAAGTCTAATTTCTCCCATGTTGAGAATA
AATTTTTCATCTATGATTTGCTGATAGAGAAGAGCTTGGTAAGGGAGCAATTCAAGGAAACTATTTTGCCATGCACATTTCTGATCAATT
CCCACAGATTCTGGTCAAATGAAAGATATTCTATCCAACATTTAAACATTGAAAAATTTAACTGAACTTACTTATCACTGATGTGTATTT
ATCCCAGAAATTAATTAATATCTGTGAAAAATAAAAATATTTCAATACTATCCGTGCTTCTTGGAAAATGAACTATAAAAAAGGGTCACA
ATTTTTCTGAAATTGGCATGAAAACATTCAAGATAAAAATAATAGACTAAACATTATTTTCTGTTATGCATAATTCTATGAAAAAGCAAG
GTAATTTAAAAAGAGTTTTAAAATGTGTGTTTGAATCTTTTCCAATTTAACCAAGTGAGAAGTAGCAATGATTTACATTGTTATGATGAT
AATGTGAATAAGAAACCTTTTAGAGTATATGATTTTACATTGCTATCAAACCTATCAAAGAAAAGGCAATTGGAATTTGGAGGAATGTTT
GTATATATGCACATAGAGTCTATTTGTGTGTGTGTGAACGCACATATATATACATCTATATACTTATAACTATATATAAAAGCATATATA
TAATCCTATATTCTTCACTGGTGCATGTGAATCACAGAAAGCCCTATTTTAGACTTCATCTGAAATTCGTTGGGTTACATTTTGAATCCT
GATGAAAAAAGCAAAAATCCAAATTAAATGGACTGATTGCTAAGAGTACGTAAAATCATATTCAAAAGCTGGCCAGAAGAATAAAGCTAG
AGAAGCTGCTAAATCTAGAAAACACAATCAGATGCCACAGTTGTCACAAATCAGACTTGTAAGTATAGCAATCTGTATTGTAGGTTCTGC
CGATTGCAGGCTTAGCTAAAGTCACATTGAAAAACATTGCATCAAGCTTCATTCACACTGAAGTAAATGAACATTGGTCCTCCTATTCAA
ATAAGCCAGTCTTTAGCATAAGCAAAATCCAGATTTGCATGATTTTTATTATATAGCTACAGAACTGTGACCACTGTGAAAAAGGAAAAT
TATACAAGGAGATTGCTCTTGGAGGATTTGGTATGAATCAGCTGAGGTAGGAACAAGAGTCTGAATTGGGGACCTGCTGACCTTCCAAGA
AGTAGAAGGCCATCAGAAGAAAATCACTGTTACTTAGAGAAGAGACAACACTAAAGTACTTCACCTGGTAGTGTTAATTGGATGTTAATT
ATGAGCTCGGTTTAATTTCAATAAGCAAGAAAATATAATCAGATGACTGATTTAAAAAAAAACAACAACAATGTGCCCATCTAGCCTTTA
ATGTGACATGTCAAATGCAAATAATAAATTATGTTATTCAGTATCAGTTGTTTGCATGTCTTAGCACAACAAAGGATTTACAGTCTGAGG
GCCAAGAGAGAAAAAATGCTTTTTTCTTAAAACAGCATATTTAAAAGACAAGACCTCATCATTTCAGTAGTGTACATAGATTAGTGACTG
AAGGAGCCAGTGCTAGCCTTTTTAAGTAGGTCAGGCTTTTAGAGCTGAAAGAGATTTTAAAGACCAGCCAATTCAACTCCTACACCTTGG
AGCTGAGGAAACAGACAGAGGTGAAGTGACTTGCCTGTAGTTATAAACTGGACTAATGGCAGTACTGAGACTCAAATTCTTGTCTCATGT
TTTCTTCTCTAGTGCTTTTTCCACTACACTTTTTAGACAGAAGAGTAGCTGGAAAAAGAATGCCTAACTGATTTACTAAAGAGTCTATTC
ATGGAATCCAAGGGCTCCAAATTGTGCTAATTCTGCTCAGGATGAAACAAATCCCCACGCTGAAGTGGAGAAATATTTTCATAATTGAAG
GAACATATCCCATTGATTGTCTACACTTTCTTCTCTCTGTTTGTTGCTATTGGTAAGGCTAGGCTATGTTCTGTTATCACAAAATTCTAG
GACTTGTTTAAAGAACTTAAAGGTCAGTTTCTTAGTTTCTCTTTGTGATTGAGGATGAGCAAGCCATTGATACACCAAGAGCTGCTGAGT
GTTGGAGGTTGCCTGGTGAAACTGGCAGGCCCTGTTGTTGACATTTCCCCAGAGCTAAAATGTCCTCATACTCAAACCAACTGTGCTGCC
CAAGTTAGTGAAATTATCCATCAGCACTAACACCACCCTTTGGGTTCATGCTCATCCCTGCACTCCATGTGACCTTTGAGCCCAGATACC
CTTCTAGAAGGTGAATGAAAGCCCCACATGTCCCGCAAGACTTAGTCTGCATAAAAGATTTAAAAGGATTTTTTTTTCTCTACAGTCCAT
TTATATGATACTGTTAGAAGTGAAGAATTTTGAAACTACATACACTGGCCTCTGAAAATGGTTCTTGTGGCTCAGAAATAGTATATTGTT
CTGTTGCTTGTTTTTGCTGAACTGTAGAGAAAACACCAGAGTAAAATTCCATGTAAATTGCTAAGGCATCGAATCAGAACTGTCCTTGGG
CGTTGTAACAGTGCAGAAAATCTCATTTAGTTTTTTTCTTTTTTTTTTTCAGTTAACTACTTGTTTGTTTCTTTTCAGAATAGGCACTTT
TTTTTGAGTAGAAAACCTCTTCTTTCTCCACAGATACATCTCTTTTTGTTCACGCCTTGAAGACTTCAGAAAAATAGAAGCTCACTTCCT
TCCATAAAGGTGAAGAACATCTTGATGAATAAACAGTCAACTACCAAGTTCACATATTTGCCTATGAAGTGAGAGCTATTTCTAAGAAAC
TTCAAAAAGATCAAAACGAGGCAATTTTATAGCTTTTTGTTACCTAATCTACAAAGTACTAATTTCCTTGTGTTTAGCTTTGTTGTCACT
GTTACTGAGTAAATACCCATTTCTGTTACATATGGTACATTTTTTGCTTCACTTATTTTCCTGAGTTCCCATGATTTTTTTTCTGTAGTT
TCTCATTCATTTTAAAACCCATAATCTTCATCTATTTTTAGAAGAAAGTGTAAATGCACAGTTGTACGTTTGTTGAGAGTTTTTATGGCA

>56562_56562_1_MYO10-ST6GALNAC3_MYO10_chr5_16935897_ENST00000507288_ST6GALNAC3_chr1_76779490_ENST00000328299_length(amino acids)=324AA_BP=25
MTSASRSGTRRVRDCAGTMDNFFTERKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRTHYGYINVKTQE
PLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNM
RKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMINDTYCKTEGYRKV

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>56562_56562_2_MYO10-ST6GALNAC3_MYO10_chr5_16935897_ENST00000513610_ST6GALNAC3_chr1_76779490_ENST00000328299_length(transcript)=7171nt_BP=476nt
GCCGCGGCGCGGGACTGCTCACCTCCAAGCGCTCGCGCGGGGATCGCGGCTCCTGCTCACTTTGCGGCCCGCTGTCCTCCTGCCCGCCCC
GAGGGCCCCCGGCCGGAGCGCAGAGGGAGGGGGCCGCGCTCGCCAGCACCCCGCCGCCTTCCCCCGCCTGGGGGAAGAATGTGCCACCAG
CTGTTCTCCGCTTGCGAGCGCTGCGCCCAGTAGTGAGGAACTTGGAGGAAGAAGAGACAAAGGCTGCCGTCGGGACGGGCGAGTTAGGGA
CTTGGGTTTGGGCGAACAAAAGGTGAGAAGGACAAGAAGGGACCGGGCGATGGCAGCAGGGGAGCCCCGCGGGCGCGCGTCCTCGGGAGT
GGCGCCGTGACACGCATGGTTTCCCCGGACCCGCGGCGGCGCTGACTTCCGCGAGTCGGAGCGGCACTCGGCGAGTCCGGGACTGCGCTG
GAACAATGGATAACTTCTTCACCGAGAGAAAGTCTGTGATTGCTGTGAGCTTCATAGCAGCGTTCCTTTTCCTGCTGGTTGTGCGTCTTG
TAAATGAAGTGAATTTCCCATTGCTACTAAACTGCTTTGGACAACCTGGTACAAAGTGGATACCATTCTCCTACACATACAGGCGGCCCC
TTCGAACTCACTATGGATACATAAATGTGAAGACACAAGAGCCTTTGCAACTGGACTGTGACCTTTGTGCCATAGTGTCAAACTCAGGTC
AGATGGTTGGCCAGAAGGTGGGAAATGAGATAGATCGATCCTCCTGCATTTGGAGAATGAACAATGCCCCCACCAAAGGTTATGAAGAAG
ATGTCGGCCGCATGACCATGATTCGAGTTGTGTCCCATACCAGCGTTCCTCTTTTGCTAAAAAACCCTGATTATTTTTTCAAGGAAGCGA
ATACTACTATTTATGTTATTTGGGGACCTTTCCGCAATATGAGGAAAGATGGCAATGGCATCGTTTACAACATGTTGAAAAAGACAGTTG
GTATCTATCCGAATGCCCAAATATACGTGACCACAGAGAAGCGCATGAGTTACTGTGATGGAGTTTTTAAGAAGGAAACTGGGAAGGACA
GAGTCCAGTCTGGCTCATATCTCAGCACAGGGTGGTTTACCTTCCTTCTGGCCATGGACGCCTGTTATGGCATTCACGTCTACGGGATGA
TAAATGACACCTACTGCAAGACAGAAGGGTATAGAAAAGTCCCCTACCATTATTATGAACAAGGAAGAGATGAGTGTGATGAATATTTTC
TTCATGAACATGCCCCATATGGGGGTCATAGGTTTATCACTGAAAAGAAAGTGTTTGCTAAATGGGCCAAGAAGCACAGGATAATATTTA
CACATCCAAACTGGACATTGTCTTGATAATGGTTTTCCTGATCTTGCCGCATCACTTAATGTGATCCCCATACTGCAACTGTGATGCTGA
TGATGCTAATGGAGATGATGGTAATGATAAAGACAACAACAATGATTATCAAGTTCCTGTACACTCTCAGATGTGGATGGTGACTCTGCT
AGTAATTTAAACTTGGCATTTCATGGAGGATGGTTGTGCTCATGATGTTCTTTCTGGAGGTTCAACACTACGTACCGCACTTTATAATTT
AACTGGAATTGAGATGAAGGCCAGTGACATGACAACTGTGACCTAAGAAATGGGAAGATTATCTTTCAAGATAGCTGCCTAGAATTGTTC
AACAGTGAGTAACTTCCAGAAGCCAAAAGAGTTTGGCTTCATGAGGCAAGGTGATTGACTCAATGGCTTGTTGAATCTCAGCAGTTCCGC
CATCTTGAAGAATGATTGATTGTCAAACACTGACCCAAGAACTGCTATCAGGGTGCAAGTATCTTACTACTTAGCCTAAGGATGGGAAAA
TATCTCTTCCTAATATACCATCTTTCTACAGTATTTCCTACAGCTAAAGCCTCAGGCCATTGCCTAATTAACAATGAAGATTTCATGGAC
ATCCTACACTTCAGGATTACTTGACTATCTCAAACACATAAATCAAAATGGGCCAAGTAGCAAATCTTGATGAATTTCCACTCTTACCAT
CCATTCTTACTACCAACAGTATAACTGAACATGTGATTAGAATGATCTATATTAATGTTTAGTTATTTTTGGTTGAGTGCTAAATATTTC
AGAAGGCTACTTAACATGTAAGATACCAACTTCAACACTGTAATAACATATACTGTGAAAACATTCCTAAAAAGTAACCAAAGGGTTTGC
TAACTCTGCTTCAACATCCAACAACACAAAACTATATGATTTTTAAAATCATGAAATAGAGACAGCAAAGCATATTTTTACATCAATTTG
TATCCTATCATACTTCATAATATATATTTGTATATTCAAATTTCTATTTTATAGGCCCAAGGTGTGTTTCTCCAAACATTACATTCTCAT
TGCCAAGTGCCAGCTGTTACACATGGAGAGGAAATGATTCCTTATATTAAACCTGACCAGAGCTTTTTGCCTTCTAGGGATTTATTTTTC
CCATAGTGTATCAGTTGTTATGCCACAATAACAACAATAATAATGTTCTTAATGTCCAAAGTGCTTTGTCATTTAGAGTCCTTTAACATC
TGTTATACCATGTGATGCCCTTGAACACCCCATTGGGCTATTGTCTGTGTATTCTGCTCTCTTTAGCAGATGATCTGTAATTTGGTCATT
GTTCTGTTATATTCCAGATTGCTCTACTTGCTAATATTTGTATAGAATAGAATTTATGTAAACTAGTAACCAGTTGATCTCTGTGCCAAA
TACATTATATCAGGATTACACAAAAAGTATCACAAAGGATGGTCTTGGCCATATGCTAGGGCCCCTGTGAAAATAAGTAGTTTTGAGAAG
TTTTTCTATATACGTATATATACACGTGTGGTTCTATTTAGGTGGGGAAAAAATGAAAAAGCAGGGACAACAGGAGGAAATGAAGGCAGA
GAAATATAGTTTCCTTTCCTAGGATTGAGACAATTCTATTTTTCATATACTCGTTGCTCATTAAATAGTAAAGGGTTGATTTGCTGCAAG
AGTAGCTGAGAATTCAAAAACATCCTTGCAGAATGATTCAAAAGACAAAAGCCAGGCTCAACTTATAGAATGTTTTGGAAACTGGAAGTA
ATGATACATTTCACTTCAGAAGCACTTGTAGGTCTTTACTAGTGCTAAGTATTATGGTGAGCTATCATTAAAGTGTGCCATCTTGGATAA
AGGCCTTTTGCCTACTCTCTTCTGCAATTTTGACACCTCAATATTCACACCCATAAACATTACTAAGCCCCAGTTCTATCGTTGGAAGGA
GTTGTTATTCTTTTGTTGTTCCCTTATGCAATTTTTAATTCTATGAATGTTAAGTTTTTTTGAGCTAATGATAGATAGAAATGCCCACTC
AAAGAAAAATAAACAGAGACAAATGTTAAAATTGCCATACAGACTGTTTTTCCCCCTGTTGTTTCACTTTAAAATAAAAAGAAATCCTTG
ATTAATCAGAATGGCTTGGGACATGAACTTAATTTATTTAGTTTTCTAATAAATGAAGGGCCAACTCTTATTTGTTCTAGCCCCTACTGA
TGAGAAACATTTGAAAACTTGCTTGCTCTCCTGCCTCGTTGTAGCTTTCTCTGATGAAGACTTCTGCAGTATATTGTATCCCTCACTCTA
TAGCAGAAGGTGTGTGTGGAATATGTAGACTCCAGTGTTTTCTTAGGAGGGGTGGGAAAGGGCTTTCTTTCCTCTCCTCTCCTCTCGTCT
CCTCTTTCTTTCCTTTCTTTTTGCAACTAAACTGCTACTCTACACTTTTTATTGTTGTTTTCTTTGTCTTTTTCTTTCTACAAACAGGAA
ACAAAAAAAAAAAAAAACAAGTTTTTCTCAATTTGGAGACTCAATTGAATAATTTCCAGTATAATCAGCATTTTGATAGAATCTCACAAC
TTATTTTTCTCTGCTTTTATTTCCTGTTTTTCTTTGTTCCATCTTTCTAATTCTAGTGAAAATGCAAAGTCTAATTTCTCCCATGTTGAG
AATAAATTTTTCATCTATGATTTGCTGATAGAGAAGAGCTTGGTAAGGGAGCAATTCAAGGAAACTATTTTGCCATGCACATTTCTGATC
AATTCCCACAGATTCTGGTCAAATGAAAGATATTCTATCCAACATTTAAACATTGAAAAATTTAACTGAACTTACTTATCACTGATGTGT
ATTTATCCCAGAAATTAATTAATATCTGTGAAAAATAAAAATATTTCAATACTATCCGTGCTTCTTGGAAAATGAACTATAAAAAAGGGT
CACAATTTTTCTGAAATTGGCATGAAAACATTCAAGATAAAAATAATAGACTAAACATTATTTTCTGTTATGCATAATTCTATGAAAAAG
CAAGGTAATTTAAAAAGAGTTTTAAAATGTGTGTTTGAATCTTTTCCAATTTAACCAAGTGAGAAGTAGCAATGATTTACATTGTTATGA
TGATAATGTGAATAAGAAACCTTTTAGAGTATATGATTTTACATTGCTATCAAACCTATCAAAGAAAAGGCAATTGGAATTTGGAGGAAT
GTTTGTATATATGCACATAGAGTCTATTTGTGTGTGTGTGAACGCACATATATATACATCTATATACTTATAACTATATATAAAAGCATA
TATATAATCCTATATTCTTCACTGGTGCATGTGAATCACAGAAAGCCCTATTTTAGACTTCATCTGAAATTCGTTGGGTTACATTTTGAA
TCCTGATGAAAAAAGCAAAAATCCAAATTAAATGGACTGATTGCTAAGAGTACGTAAAATCATATTCAAAAGCTGGCCAGAAGAATAAAG
CTAGAGAAGCTGCTAAATCTAGAAAACACAATCAGATGCCACAGTTGTCACAAATCAGACTTGTAAGTATAGCAATCTGTATTGTAGGTT
CTGCCGATTGCAGGCTTAGCTAAAGTCACATTGAAAAACATTGCATCAAGCTTCATTCACACTGAAGTAAATGAACATTGGTCCTCCTAT
TCAAATAAGCCAGTCTTTAGCATAAGCAAAATCCAGATTTGCATGATTTTTATTATATAGCTACAGAACTGTGACCACTGTGAAAAAGGA
AAATTATACAAGGAGATTGCTCTTGGAGGATTTGGTATGAATCAGCTGAGGTAGGAACAAGAGTCTGAATTGGGGACCTGCTGACCTTCC
AAGAAGTAGAAGGCCATCAGAAGAAAATCACTGTTACTTAGAGAAGAGACAACACTAAAGTACTTCACCTGGTAGTGTTAATTGGATGTT
AATTATGAGCTCGGTTTAATTTCAATAAGCAAGAAAATATAATCAGATGACTGATTTAAAAAAAAACAACAACAATGTGCCCATCTAGCC
TTTAATGTGACATGTCAAATGCAAATAATAAATTATGTTATTCAGTATCAGTTGTTTGCATGTCTTAGCACAACAAAGGATTTACAGTCT
GAGGGCCAAGAGAGAAAAAATGCTTTTTTCTTAAAACAGCATATTTAAAAGACAAGACCTCATCATTTCAGTAGTGTACATAGATTAGTG
ACTGAAGGAGCCAGTGCTAGCCTTTTTAAGTAGGTCAGGCTTTTAGAGCTGAAAGAGATTTTAAAGACCAGCCAATTCAACTCCTACACC
TTGGAGCTGAGGAAACAGACAGAGGTGAAGTGACTTGCCTGTAGTTATAAACTGGACTAATGGCAGTACTGAGACTCAAATTCTTGTCTC
ATGTTTTCTTCTCTAGTGCTTTTTCCACTACACTTTTTAGACAGAAGAGTAGCTGGAAAAAGAATGCCTAACTGATTTACTAAAGAGTCT
ATTCATGGAATCCAAGGGCTCCAAATTGTGCTAATTCTGCTCAGGATGAAACAAATCCCCACGCTGAAGTGGAGAAATATTTTCATAATT
GAAGGAACATATCCCATTGATTGTCTACACTTTCTTCTCTCTGTTTGTTGCTATTGGTAAGGCTAGGCTATGTTCTGTTATCACAAAATT
CTAGGACTTGTTTAAAGAACTTAAAGGTCAGTTTCTTAGTTTCTCTTTGTGATTGAGGATGAGCAAGCCATTGATACACCAAGAGCTGCT
GAGTGTTGGAGGTTGCCTGGTGAAACTGGCAGGCCCTGTTGTTGACATTTCCCCAGAGCTAAAATGTCCTCATACTCAAACCAACTGTGC
TGCCCAAGTTAGTGAAATTATCCATCAGCACTAACACCACCCTTTGGGTTCATGCTCATCCCTGCACTCCATGTGACCTTTGAGCCCAGA
TACCCTTCTAGAAGGTGAATGAAAGCCCCACATGTCCCGCAAGACTTAGTCTGCATAAAAGATTTAAAAGGATTTTTTTTTCTCTACAGT
CCATTTATATGATACTGTTAGAAGTGAAGAATTTTGAAACTACATACACTGGCCTCTGAAAATGGTTCTTGTGGCTCAGAAATAGTATAT
TGTTCTGTTGCTTGTTTTTGCTGAACTGTAGAGAAAACACCAGAGTAAAATTCCATGTAAATTGCTAAGGCATCGAATCAGAACTGTCCT
TGGGCGTTGTAACAGTGCAGAAAATCTCATTTAGTTTTTTTCTTTTTTTTTTTCAGTTAACTACTTGTTTGTTTCTTTTCAGAATAGGCA
CTTTTTTTTGAGTAGAAAACCTCTTCTTTCTCCACAGATACATCTCTTTTTGTTCACGCCTTGAAGACTTCAGAAAAATAGAAGCTCACT
TCCTTCCATAAAGGTGAAGAACATCTTGATGAATAAACAGTCAACTACCAAGTTCACATATTTGCCTATGAAGTGAGAGCTATTTCTAAG
AAACTTCAAAAAGATCAAAACGAGGCAATTTTATAGCTTTTTGTTACCTAATCTACAAAGTACTAATTTCCTTGTGTTTAGCTTTGTTGT
CACTGTTACTGAGTAAATACCCATTTCTGTTACATATGGTACATTTTTTGCTTCACTTATTTTCCTGAGTTCCCATGATTTTTTTTCTGT
AGTTTCTCATTCATTTTAAAACCCATAATCTTCATCTATTTTTAGAAGAAAGTGTAAATGCACAGTTGTACGTTTGTTGAGAGTTTTTAT

>56562_56562_2_MYO10-ST6GALNAC3_MYO10_chr5_16935897_ENST00000513610_ST6GALNAC3_chr1_76779490_ENST00000328299_length(amino acids)=324AA_BP=25
MTSASRSGTRRVRDCAGTMDNFFTERKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRTHYGYINVKTQE
PLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNM
RKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMINDTYCKTEGYRKV

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Fusion Gene PPI Analysis for MYO10-ST6GALNAC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MYO10-ST6GALNAC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MYO10-ST6GALNAC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source