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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO1C-SMTNL2 (FusionGDB2 ID:56638)

Fusion Gene Summary for MYO1C-SMTNL2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1C-SMTNL2
Fusion gene ID: 56638
HgeneTgene
Gene symbol

MYO1C

SMTNL2

Gene ID

4643

342527

Gene namemyosin IEsmoothelin like 2
SynonymsFSGS6|HuncM-IC|MYO1C-
Cytomap

15q22.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IeMYO1E variant proteinmyosin-ICunconventional myosin 1Esmoothelin-like protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359786, ENST00000361007, 
ENST00000438665, ENST00000545534, 
ENST00000575158, ENST00000573198, 
ENST00000338859, ENST00000389313, 
Fusion gene scores* DoF score6 X 8 X 5=2403 X 3 X 3=27
# samples 73
** MAII scorelog2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYO1C [Title/Abstract] AND SMTNL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO1C(1381910)-SMTNL2(4510656), # samples:2
Anticipated loss of major functional domain due to fusion event.MYO1C-SMTNL2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYO1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMTNL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3BD-01AMYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
ChimerDB4UCECTCGA-AJ-A3BD-01AMYO1Cchr17

1381910

-SMTNL2chr17

4510656

+


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Fusion Gene ORF analysis for MYO1C-SMTNL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000359786ENST00000338859MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000359786ENST00000389313MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
Frame-shiftENST00000359786ENST00000389313MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000361007ENST00000338859MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000361007ENST00000389313MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
Frame-shiftENST00000361007ENST00000389313MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000438665ENST00000338859MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000438665ENST00000389313MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
Frame-shiftENST00000438665ENST00000389313MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000545534ENST00000338859MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000545534ENST00000389313MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
Frame-shiftENST00000545534ENST00000389313MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000575158ENST00000338859MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
Frame-shiftENST00000575158ENST00000338859MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
Frame-shiftENST00000575158ENST00000389313MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
In-frameENST00000359786ENST00000338859MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
In-frameENST00000361007ENST00000338859MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
In-frameENST00000438665ENST00000338859MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
In-frameENST00000545534ENST00000338859MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
In-frameENST00000575158ENST00000389313MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
intron-3CDSENST00000573198ENST00000338859MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
intron-3CDSENST00000573198ENST00000338859MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+
intron-3CDSENST00000573198ENST00000389313MYO1Cchr17

1381704

-SMTNL2chr17

4510656

+
intron-3CDSENST00000573198ENST00000389313MYO1Cchr17

1381910

-SMTNL2chr17

4510656

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000575158MYO1Cchr171381910-ENST00000389313SMTNL2chr174510656+223812841501301383
ENST00000359786MYO1Cchr171381704-ENST00000338859SMTNL2chr174510656+257916202771746489
ENST00000438665MYO1Cchr171381704-ENST00000338859SMTNL2chr174510656+24201461401587515
ENST00000361007MYO1Cchr171381704-ENST00000338859SMTNL2chr174510656+22581299821425447
ENST00000545534MYO1Cchr171381704-ENST00000338859SMTNL2chr174510656+242514662431592449

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000575158ENST00000389313MYO1Cchr171381910-SMTNL2chr174510656+0.0033418970.9966581
ENST00000359786ENST00000338859MYO1Cchr171381704-SMTNL2chr174510656+0.0050548420.9949451
ENST00000438665ENST00000338859MYO1Cchr171381704-SMTNL2chr174510656+0.0030470150.996953
ENST00000361007ENST00000338859MYO1Cchr171381704-SMTNL2chr174510656+0.0024998220.9975001
ENST00000545534ENST00000338859MYO1Cchr171381704-SMTNL2chr174510656+0.0017081240.9982919

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Fusion Genomic Features for MYO1C-SMTNL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYO1C-SMTNL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1381910/chr17:4510656)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000359786-1132139_1484311064.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000359786-1132192_1964311064.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000361007-1132139_1483961029.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000361007-1132192_1963961029.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000438665-1132139_1484121045.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000438665-1132192_1964121045.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000575158-1132139_1483961029.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000575158-1132192_1963961029.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000359786-1032139_1484041064.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000359786-1032192_1964041064.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000361007-1032139_1483691029.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000361007-1032192_1963691029.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000438665-1032139_1483851045.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000438665-1032192_1963851045.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000575158-1032139_1483691029.0Nucleotide bindingNote=ATP
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000575158-1032192_1963691029.0Nucleotide bindingNote=ATP
TgeneSMTNL2chr17:1381704chr17:4510656ENST0000033885968351_458275318.0DomainCalponin-homology (CH)
TgeneSMTNL2chr17:1381910chr17:4510656ENST0000033885968351_458275318.0DomainCalponin-homology (CH)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000359786-113247_7314311064.0DomainMyosin motor
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000359786-1132734_7574311064.0DomainIQ 1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000359786-1132758_7864311064.0DomainIQ 2
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000359786-1132885_10594311064.0DomainTH1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000361007-113247_7313961029.0DomainMyosin motor
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000361007-1132734_7573961029.0DomainIQ 1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000361007-1132758_7863961029.0DomainIQ 2
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000361007-1132885_10593961029.0DomainTH1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000438665-113247_7314121045.0DomainMyosin motor
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000438665-1132734_7574121045.0DomainIQ 1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000438665-1132758_7864121045.0DomainIQ 2
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000438665-1132885_10594121045.0DomainTH1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000575158-113247_7313961029.0DomainMyosin motor
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000575158-1132734_7573961029.0DomainIQ 1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000575158-1132758_7863961029.0DomainIQ 2
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000575158-1132885_10593961029.0DomainTH1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000359786-103247_7314041064.0DomainMyosin motor
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000359786-1032734_7574041064.0DomainIQ 1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000359786-1032758_7864041064.0DomainIQ 2
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000359786-1032885_10594041064.0DomainTH1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000361007-103247_7313691029.0DomainMyosin motor
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000361007-1032734_7573691029.0DomainIQ 1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000361007-1032758_7863691029.0DomainIQ 2
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000361007-1032885_10593691029.0DomainTH1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000438665-103247_7313851045.0DomainMyosin motor
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000438665-1032734_7573851045.0DomainIQ 1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000438665-1032758_7863851045.0DomainIQ 2
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000438665-1032885_10593851045.0DomainTH1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000575158-103247_7313691029.0DomainMyosin motor
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000575158-1032734_7573691029.0DomainIQ 1
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000575158-1032758_7863691029.0DomainIQ 2
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000575158-1032885_10593691029.0DomainTH1
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000359786-1132608_6304311064.0RegionActin-binding
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000361007-1132608_6303961029.0RegionActin-binding
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000438665-1132608_6304121045.0RegionActin-binding
HgeneMYO1Cchr17:1381704chr17:4510656ENST00000575158-1132608_6303961029.0RegionActin-binding
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000359786-1032608_6304041064.0RegionActin-binding
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000361007-1032608_6303691029.0RegionActin-binding
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000438665-1032608_6303851045.0RegionActin-binding
HgeneMYO1Cchr17:1381910chr17:4510656ENST00000575158-1032608_6303691029.0RegionActin-binding
TgeneSMTNL2chr17:1381704chr17:4510656ENST000003388596855_88275318.0Coiled coilOntology_term=ECO:0000255
TgeneSMTNL2chr17:1381704chr17:4510656ENST000003893136855_88419462.0Coiled coilOntology_term=ECO:0000255
TgeneSMTNL2chr17:1381910chr17:4510656ENST000003388596855_88275318.0Coiled coilOntology_term=ECO:0000255
TgeneSMTNL2chr17:1381910chr17:4510656ENST000003893136855_88419462.0Coiled coilOntology_term=ECO:0000255
TgeneSMTNL2chr17:1381704chr17:4510656ENST0000038931368351_458419462.0DomainCalponin-homology (CH)
TgeneSMTNL2chr17:1381910chr17:4510656ENST0000038931368351_458419462.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for MYO1C-SMTNL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56638_56638_1_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000359786_SMTNL2_chr17_4510656_ENST00000338859_length(transcript)=2579nt_BP=1620nt
GGAGCCCAGGGTCCCCCATGGGTGGCTGCATCGGCTCCTCTGGTTACCTGGGACAACAGGCATTTCCTCCATCCCCAGCCCCTCCTCTTC
CTGCTCCAACCATCCGGGCCAAGAGGCCTCCCAGTCAGACCTGGACGGCTCCAGCCGTGTCCTGAGGAGCTGGACCAGCCACATCCCCTG
GGGCTGCAGTTGAAGCAGAACCAAGTGGCCATCCCGGCGTTAGACCGTAGGTTCCTGGTCCCGGAGTGGTCGGAGCCCGCCAGTGGGCAG
GCAGCTCTTGCTCACAGGCCGCGGTGCCCAGGCCGCTGGCTCTCCGCAGGGCGGAATGGCGCTGCAAGTGGAGCTGGTACCCACCGGGGA
GATCATCCGCGTGGTTCATCCCCACAGGCCCTGCAAGCTTGCCCTGGGCAGTGACGGGGTTCGGGTGACCATGGAGAGTGCGCTCACCGC
CCGTGACCGGGTGGGGGTGCAGGATTTCGTGCTGCTGGAGAACTTCACCAGCGAGGCCGCCTTCATCGAGAACCTGCGGCGGCGATTTCG
GGAGAATCTCATCTACACCTACATTGGCCCCGTCCTGGTCTCTGTCAATCCCTACCGGGACCTGCAGATCTACAGCCGGCAGCATATGGA
GCGTTACCGTGGCGTCAGCTTCTATGAAGTGCCCCCTCACCTGTTTGCCGTGGCGGACACTGTGTACCGAGCACTGCGCACGGAGCGTCG
GGACCAGGCTGTGATGATCTCTGGGGAGAGCGGGGCAGGCAAGACCGAGGCCACCAAGAGGCTGCTGCAGTTCTATGCAGAGACCTGCCC
AGCCCCCGAGCGCGGAGGTGCCGTGCGGGACCGGCTGCTACAGAGCAACCCGGTGCTGGAGGCCTTTGGAAATGCCAAGACCCTCCGGAA
CGATAACTCCAGCAGGTTCGGGAAGTACATGGATGTGCAGTTTGACTTCAAGGGTGCCCCCGTGGGTGGCCACATCCTCAGTTACCTCCT
GGAAAAGTCACGAGTGGTGCACCAGAATCATGGGGAGCGGAACTTCCACATCTTCTACCAGCTGCTGGAGGGGGGTGAGGAGGAGACTCT
TCGCAGGCTGGGCTTGGAACGGAACCCCCAGAGCTACCTGTACCTGGTGAAGGGCCAGTGTGCCAAAGTCTCCTCCATCAACGACAAGAG
TGACTGGAAGGTCGTCAGGAAGGCTCTGACAGTCATTGATTTCACCGAGGATGAAGTGGAGGACCTGCTGAGCATCGTGGCCAGCGTCCT
TCATTTGGGCAACATCCACTTTGCTGCCAACGAGGAGAGCAATGCCCAGGTCACCACCGAGAACCAGCTCAAGTATCTGACCAGGCTCCT
CAGCGTGGAAGGCTCGACGCTGCGAGAAGCCCTGACACACAGGAAGATCATCGCCAAGGGGGAGGAGCTCCTGAGCCCGCTGAACCTGGA
GCAGGCCGCGTACGCACGAGACGCCCTCGCCAAGGCTGTGTACAGCCGCACTTTTACCTGGCTCGTCGGGAAGATCAACAGGTCGCTGGC
CTCCAAGGACGTGGAGAGCCCCAGCTGGCGGAGCACCACGGTTCTCGGGCTCCTGGATATTTATGGCTTTGAAGTGTTTCAGCATAACAG
GAATCTGGCCAACTGTGAGCGCCTCATCGAAGTGGAGGACATGATGGTGATGGGCCGCAAGCCGGACCCCATGTGTGTCTTCACCTACGT
CCAGTCGCTGTACAACCACCTGCGTCGCTTCGAGTAAAGCCCCTGAGCCTGGATTGCCAAAGAGCAGCCCCAGGAAGAGGCCGGGGGTCC
GCTTGCGATTCCCCAGCCAGGATGCCCCCAGGAGCCTTGCCGTTTGGTGTGAGCGCGCTGTTTGTTCTGTGGCATGTGACGGCACTCCCC
TTCGAGCCCAGCTGTGTTACTGATTAAAAGTACTGCTGAGCTGTGGTCCGACAGCACTGATCACAGCCAAGGGCTTGGAGGAAAAGGAAA
AATTATGAGAGAGAGAGAGACATTGGTGCTAAGTAATGATCTTCCTAAAGAAATGCTTGTGTTTATAGCTTCCAGAATGCTAATCTACAA
TTTTCCCTCTGGTGAATTCGATACATCGGCTTTACAGGGTTACAGTGATTACCAAGTGTTTTTTTTTATCAAAATACCCAGAGTTTTTTA
CTTCCTCACGCGATTGTAGGTTCCTCTCCTCCCTCCCTCTGGGCCACTGCCAGGAAACAGAGAGACCGCTTAATCAGCAGCTTGACAAAG
AAGACCTCAAGTCTTGGGAAGAAACAGTTTAATCACTCCCAAGTCCTGGGCAACAGATGACCTTCAAGTCACCTCCGCTCTCCGGGGAGA
TGGGAAGGCTCTCCTCTCGGTCCCAAAGTCCTCCTGTTCTTCCCAGGAGGCCCCACAAGTGTTTGGCTAAGCACAGGCTCTCGGGAATTT
AACACTTTTGGGGAAGGAATAGGCCCTTTGTGCTGAGAGAGAGTTTTTATTCACATCTTTTTTAGGGGATTTGCTGCAGATATTTATAAA

>56638_56638_1_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000359786_SMTNL2_chr17_4510656_ENST00000338859_length(amino acids)=489AA_BP=447
MLTGRGAQAAGSPQGGMALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFREN
LIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAP
ERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRR
LGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSV
EGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNRNL

--------------------------------------------------------------
>56638_56638_2_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000361007_SMTNL2_chr17_4510656_ENST00000338859_length(transcript)=2258nt_BP=1299nt
AGAGTGCGCCCGGGCCGCGGATCCCCAAGCCCGCCACGCCGCCCAGCCCGGCCCCGCCCGCGCCGGAAGAGCCACGCCGGCCCTGGGCAG
TGACGGGGTTCGGGTGACCATGGAGAGTGCGCTCACCGCCCGTGACCGGGTGGGGGTGCAGGATTTCGTGCTGCTGGAGAACTTCACCAG
CGAGGCCGCCTTCATCGAGAACCTGCGGCGGCGATTTCGGGAGAATCTCATCTACACCTACATTGGCCCCGTCCTGGTCTCTGTCAATCC
CTACCGGGACCTGCAGATCTACAGCCGGCAGCATATGGAGCGTTACCGTGGCGTCAGCTTCTATGAAGTGCCCCCTCACCTGTTTGCCGT
GGCGGACACTGTGTACCGAGCACTGCGCACGGAGCGTCGGGACCAGGCTGTGATGATCTCTGGGGAGAGCGGGGCAGGCAAGACCGAGGC
CACCAAGAGGCTGCTGCAGTTCTATGCAGAGACCTGCCCAGCCCCCGAGCGCGGAGGTGCCGTGCGGGACCGGCTGCTACAGAGCAACCC
GGTGCTGGAGGCCTTTGGAAATGCCAAGACCCTCCGGAACGATAACTCCAGCAGGTTCGGGAAGTACATGGATGTGCAGTTTGACTTCAA
GGGTGCCCCCGTGGGTGGCCACATCCTCAGTTACCTCCTGGAAAAGTCACGAGTGGTGCACCAGAATCATGGGGAGCGGAACTTCCACAT
CTTCTACCAGCTGCTGGAGGGGGGTGAGGAGGAGACTCTTCGCAGGCTGGGCTTGGAACGGAACCCCCAGAGCTACCTGTACCTGGTGAA
GGGCCAGTGTGCCAAAGTCTCCTCCATCAACGACAAGAGTGACTGGAAGGTCGTCAGGAAGGCTCTGACAGTCATTGATTTCACCGAGGA
TGAAGTGGAGGACCTGCTGAGCATCGTGGCCAGCGTCCTTCATTTGGGCAACATCCACTTTGCTGCCAACGAGGAGAGCAATGCCCAGGT
CACCACCGAGAACCAGCTCAAGTATCTGACCAGGCTCCTCAGCGTGGAAGGCTCGACGCTGCGAGAAGCCCTGACACACAGGAAGATCAT
CGCCAAGGGGGAGGAGCTCCTGAGCCCGCTGAACCTGGAGCAGGCCGCGTACGCACGAGACGCCCTCGCCAAGGCTGTGTACAGCCGCAC
TTTTACCTGGCTCGTCGGGAAGATCAACAGGTCGCTGGCCTCCAAGGACGTGGAGAGCCCCAGCTGGCGGAGCACCACGGTTCTCGGGCT
CCTGGATATTTATGGCTTTGAAGTGTTTCAGCATAACAGGAATCTGGCCAACTGTGAGCGCCTCATCGAAGTGGAGGACATGATGGTGAT
GGGCCGCAAGCCGGACCCCATGTGTGTCTTCACCTACGTCCAGTCGCTGTACAACCACCTGCGTCGCTTCGAGTAAAGCCCCTGAGCCTG
GATTGCCAAAGAGCAGCCCCAGGAAGAGGCCGGGGGTCCGCTTGCGATTCCCCAGCCAGGATGCCCCCAGGAGCCTTGCCGTTTGGTGTG
AGCGCGCTGTTTGTTCTGTGGCATGTGACGGCACTCCCCTTCGAGCCCAGCTGTGTTACTGATTAAAAGTACTGCTGAGCTGTGGTCCGA
CAGCACTGATCACAGCCAAGGGCTTGGAGGAAAAGGAAAAATTATGAGAGAGAGAGAGACATTGGTGCTAAGTAATGATCTTCCTAAAGA
AATGCTTGTGTTTATAGCTTCCAGAATGCTAATCTACAATTTTCCCTCTGGTGAATTCGATACATCGGCTTTACAGGGTTACAGTGATTA
CCAAGTGTTTTTTTTTATCAAAATACCCAGAGTTTTTTACTTCCTCACGCGATTGTAGGTTCCTCTCCTCCCTCCCTCTGGGCCACTGCC
AGGAAACAGAGAGACCGCTTAATCAGCAGCTTGACAAAGAAGACCTCAAGTCTTGGGAAGAAACAGTTTAATCACTCCCAAGTCCTGGGC
AACAGATGACCTTCAAGTCACCTCCGCTCTCCGGGGAGATGGGAAGGCTCTCCTCTCGGTCCCAAAGTCCTCCTGTTCTTCCCAGGAGGC
CCCACAAGTGTTTGGCTAAGCACAGGCTCTCGGGAATTTAACACTTTTGGGGAAGGAATAGGCCCTTTGTGCTGAGAGAGAGTTTTTATT
CACATCTTTTTTAGGGGATTTGCTGCAGATATTTATAAAAAGTAACTCCCTCTGTACCACTGACCCATTTATACATAAAAAAGATGTGTT

>56638_56638_2_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000361007_SMTNL2_chr17_4510656_ENST00000338859_length(amino acids)=447AA_BP=405
MGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHL
FAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQF
DFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF
TEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVY

--------------------------------------------------------------
>56638_56638_3_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000438665_SMTNL2_chr17_4510656_ENST00000338859_length(transcript)=2420nt_BP=1461nt
GGACCCCCCGCCCCGACACCCCCACCTCCACCAACCCCACCTGGAGGGGACCCCAGCCCGGCCGCGCGGGAGGCGGGGGAGGCCGGGGAA
GCCCCGCGCTTCAGGGGCCCGGGTGGGGGCGGTGCGGGGGGCGGGCCCTCCCTCGCTGACGCCGCCGCCACCGCCGCCGAGCCCGGGACC
CGGAGCGCGGGCAGCGGAGCGGGCGCCAGGCCGGCCGGGCAGGATGCGCTACCGGGCGTCGGCCCTGGGCAGTGACGGGGTTCGGGTGAC
CATGGAGAGTGCGCTCACCGCCCGTGACCGGGTGGGGGTGCAGGATTTCGTGCTGCTGGAGAACTTCACCAGCGAGGCCGCCTTCATCGA
GAACCTGCGGCGGCGATTTCGGGAGAATCTCATCTACACCTACATTGGCCCCGTCCTGGTCTCTGTCAATCCCTACCGGGACCTGCAGAT
CTACAGCCGGCAGCATATGGAGCGTTACCGTGGCGTCAGCTTCTATGAAGTGCCCCCTCACCTGTTTGCCGTGGCGGACACTGTGTACCG
AGCACTGCGCACGGAGCGTCGGGACCAGGCTGTGATGATCTCTGGGGAGAGCGGGGCAGGCAAGACCGAGGCCACCAAGAGGCTGCTGCA
GTTCTATGCAGAGACCTGCCCAGCCCCCGAGCGCGGAGGTGCCGTGCGGGACCGGCTGCTACAGAGCAACCCGGTGCTGGAGGCCTTTGG
AAATGCCAAGACCCTCCGGAACGATAACTCCAGCAGGTTCGGGAAGTACATGGATGTGCAGTTTGACTTCAAGGGTGCCCCCGTGGGTGG
CCACATCCTCAGTTACCTCCTGGAAAAGTCACGAGTGGTGCACCAGAATCATGGGGAGCGGAACTTCCACATCTTCTACCAGCTGCTGGA
GGGGGGTGAGGAGGAGACTCTTCGCAGGCTGGGCTTGGAACGGAACCCCCAGAGCTACCTGTACCTGGTGAAGGGCCAGTGTGCCAAAGT
CTCCTCCATCAACGACAAGAGTGACTGGAAGGTCGTCAGGAAGGCTCTGACAGTCATTGATTTCACCGAGGATGAAGTGGAGGACCTGCT
GAGCATCGTGGCCAGCGTCCTTCATTTGGGCAACATCCACTTTGCTGCCAACGAGGAGAGCAATGCCCAGGTCACCACCGAGAACCAGCT
CAAGTATCTGACCAGGCTCCTCAGCGTGGAAGGCTCGACGCTGCGAGAAGCCCTGACACACAGGAAGATCATCGCCAAGGGGGAGGAGCT
CCTGAGCCCGCTGAACCTGGAGCAGGCCGCGTACGCACGAGACGCCCTCGCCAAGGCTGTGTACAGCCGCACTTTTACCTGGCTCGTCGG
GAAGATCAACAGGTCGCTGGCCTCCAAGGACGTGGAGAGCCCCAGCTGGCGGAGCACCACGGTTCTCGGGCTCCTGGATATTTATGGCTT
TGAAGTGTTTCAGCATAACAGGAATCTGGCCAACTGTGAGCGCCTCATCGAAGTGGAGGACATGATGGTGATGGGCCGCAAGCCGGACCC
CATGTGTGTCTTCACCTACGTCCAGTCGCTGTACAACCACCTGCGTCGCTTCGAGTAAAGCCCCTGAGCCTGGATTGCCAAAGAGCAGCC
CCAGGAAGAGGCCGGGGGTCCGCTTGCGATTCCCCAGCCAGGATGCCCCCAGGAGCCTTGCCGTTTGGTGTGAGCGCGCTGTTTGTTCTG
TGGCATGTGACGGCACTCCCCTTCGAGCCCAGCTGTGTTACTGATTAAAAGTACTGCTGAGCTGTGGTCCGACAGCACTGATCACAGCCA
AGGGCTTGGAGGAAAAGGAAAAATTATGAGAGAGAGAGAGACATTGGTGCTAAGTAATGATCTTCCTAAAGAAATGCTTGTGTTTATAGC
TTCCAGAATGCTAATCTACAATTTTCCCTCTGGTGAATTCGATACATCGGCTTTACAGGGTTACAGTGATTACCAAGTGTTTTTTTTTAT
CAAAATACCCAGAGTTTTTTACTTCCTCACGCGATTGTAGGTTCCTCTCCTCCCTCCCTCTGGGCCACTGCCAGGAAACAGAGAGACCGC
TTAATCAGCAGCTTGACAAAGAAGACCTCAAGTCTTGGGAAGAAACAGTTTAATCACTCCCAAGTCCTGGGCAACAGATGACCTTCAAGT
CACCTCCGCTCTCCGGGGAGATGGGAAGGCTCTCCTCTCGGTCCCAAAGTCCTCCTGTTCTTCCCAGGAGGCCCCACAAGTGTTTGGCTA
AGCACAGGCTCTCGGGAATTTAACACTTTTGGGGAAGGAATAGGCCCTTTGTGCTGAGAGAGAGTTTTTATTCACATCTTTTTTAGGGGA

>56638_56638_3_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000438665_SMTNL2_chr17_4510656_ENST00000338859_length(amino acids)=515AA_BP=473
MEGTPARPRGRRGRPGKPRASGARVGAVRGAGPPSLTPPPPPPSPGPGARAAERAPGRPGRMRYRASALGSDGVRVTMESALTARDRVGV
QDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMI
SGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVV
HQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIH
FAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVES

--------------------------------------------------------------
>56638_56638_4_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000545534_SMTNL2_chr17_4510656_ENST00000338859_length(transcript)=2425nt_BP=1466nt
GCCCCCGGCCAGAAATCTGGGCCTTTCGTGGTCAGAGGACACCGGCGGCCCCTTTGGGATCCACCCCCAATCACCACCACCTTGTTCTTC
TCTGACCCTGGATACTCTGGGTGTCCATTTTTTGGAGCCCTGAGACCCTGTTTGAAGAGGGATCCATCTCAGCCCTGGTTGTGGGGCGAG
GGTCTTGCTCAGCCTGCACCACCCTCCACCCTCCAGTAGGACCCAGAGGCAGCTGGGCTTTCCATGGCCCTGGGCAGTGACGGGGTTCGG
GTGACCATGGAGAGTGCGCTCACCGCCCGTGACCGGGTGGGGGTGCAGGATTTCGTGCTGCTGGAGAACTTCACCAGCGAGGCCGCCTTC
ATCGAGAACCTGCGGCGGCGATTTCGGGAGAATCTCATCTACACCTACATTGGCCCCGTCCTGGTCTCTGTCAATCCCTACCGGGACCTG
CAGATCTACAGCCGGCAGCATATGGAGCGTTACCGTGGCGTCAGCTTCTATGAAGTGCCCCCTCACCTGTTTGCCGTGGCGGACACTGTG
TACCGAGCACTGCGCACGGAGCGTCGGGACCAGGCTGTGATGATCTCTGGGGAGAGCGGGGCAGGCAAGACCGAGGCCACCAAGAGGCTG
CTGCAGTTCTATGCAGAGACCTGCCCAGCCCCCGAGCGCGGAGGTGCCGTGCGGGACCGGCTGCTACAGAGCAACCCGGTGCTGGAGGCC
TTTGGAAATGCCAAGACCCTCCGGAACGATAACTCCAGCAGGTTCGGGAAGTACATGGATGTGCAGTTTGACTTCAAGGGTGCCCCCGTG
GGTGGCCACATCCTCAGTTACCTCCTGGAAAAGTCACGAGTGGTGCACCAGAATCATGGGGAGCGGAACTTCCACATCTTCTACCAGCTG
CTGGAGGGGGGTGAGGAGGAGACTCTTCGCAGGCTGGGCTTGGAACGGAACCCCCAGAGCTACCTGTACCTGGTGAAGGGCCAGTGTGCC
AAAGTCTCCTCCATCAACGACAAGAGTGACTGGAAGGTCGTCAGGAAGGCTCTGACAGTCATTGATTTCACCGAGGATGAAGTGGAGGAC
CTGCTGAGCATCGTGGCCAGCGTCCTTCATTTGGGCAACATCCACTTTGCTGCCAACGAGGAGAGCAATGCCCAGGTCACCACCGAGAAC
CAGCTCAAGTATCTGACCAGGCTCCTCAGCGTGGAAGGCTCGACGCTGCGAGAAGCCCTGACACACAGGAAGATCATCGCCAAGGGGGAG
GAGCTCCTGAGCCCGCTGAACCTGGAGCAGGCCGCGTACGCACGAGACGCCCTCGCCAAGGCTGTGTACAGCCGCACTTTTACCTGGCTC
GTCGGGAAGATCAACAGGTCGCTGGCCTCCAAGGACGTGGAGAGCCCCAGCTGGCGGAGCACCACGGTTCTCGGGCTCCTGGATATTTAT
GGCTTTGAAGTGTTTCAGCATAACAGGAATCTGGCCAACTGTGAGCGCCTCATCGAAGTGGAGGACATGATGGTGATGGGCCGCAAGCCG
GACCCCATGTGTGTCTTCACCTACGTCCAGTCGCTGTACAACCACCTGCGTCGCTTCGAGTAAAGCCCCTGAGCCTGGATTGCCAAAGAG
CAGCCCCAGGAAGAGGCCGGGGGTCCGCTTGCGATTCCCCAGCCAGGATGCCCCCAGGAGCCTTGCCGTTTGGTGTGAGCGCGCTGTTTG
TTCTGTGGCATGTGACGGCACTCCCCTTCGAGCCCAGCTGTGTTACTGATTAAAAGTACTGCTGAGCTGTGGTCCGACAGCACTGATCAC
AGCCAAGGGCTTGGAGGAAAAGGAAAAATTATGAGAGAGAGAGAGACATTGGTGCTAAGTAATGATCTTCCTAAAGAAATGCTTGTGTTT
ATAGCTTCCAGAATGCTAATCTACAATTTTCCCTCTGGTGAATTCGATACATCGGCTTTACAGGGTTACAGTGATTACCAAGTGTTTTTT
TTTATCAAAATACCCAGAGTTTTTTACTTCCTCACGCGATTGTAGGTTCCTCTCCTCCCTCCCTCTGGGCCACTGCCAGGAAACAGAGAG
ACCGCTTAATCAGCAGCTTGACAAAGAAGACCTCAAGTCTTGGGAAGAAACAGTTTAATCACTCCCAAGTCCTGGGCAACAGATGACCTT
CAAGTCACCTCCGCTCTCCGGGGAGATGGGAAGGCTCTCCTCTCGGTCCCAAAGTCCTCCTGTTCTTCCCAGGAGGCCCCACAAGTGTTT
GGCTAAGCACAGGCTCTCGGGAATTTAACACTTTTGGGGAAGGAATAGGCCCTTTGTGCTGAGAGAGAGTTTTTATTCACATCTTTTTTA

>56638_56638_4_MYO1C-SMTNL2_MYO1C_chr17_1381704_ENST00000545534_SMTNL2_chr17_4510656_ENST00000338859_length(amino acids)=449AA_BP=407
MALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPP
HLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDV
QFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVI
DFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKA

--------------------------------------------------------------
>56638_56638_5_MYO1C-SMTNL2_MYO1C_chr17_1381910_ENST00000575158_SMTNL2_chr17_4510656_ENST00000389313_length(transcript)=2238nt_BP=1284nt
GTATTTGGACATTGGTTCTATTTTTAACTTTCCCGGGACTCGAGTTCGGGGGTTGGGGGAGGAAAATCCCGCTTCCTCTGGGACCCGCAG
GCCTCGGTGCCCGCCCAGCGCCCAGGCCCGCCGCGGAGTGTAGTCCCAGGCCCGGAAGCCCTGGGCAGTGACGGGGTTCGGGTGACCATG
GAGAGTGCGCTCACCGCCCGTGACCGGGTGGGGGTGCAGGATTTCGTGCTGCTGGAGAACTTCACCAGCGAGGCCGCCTTCATCGAGAAC
CTGCGGCGGCGATTTCGGGAGAATCTCATCTACACCTACATTGGCCCCGTCCTGGTCTCTGTCAATCCCTACCGGGACCTGCAGATCTAC
AGCCGGCAGCATATGGAGCGTTACCGTGGCGTCAGCTTCTATGAAGTGCCCCCTCACCTGTTTGCCGTGGCGGACACTGTGTACCGAGCA
CTGCGCACGGAGCGTCGGGACCAGGCTGTGATGATCTCTGGGGAGAGCGGGGCAGGCAAGACCGAGGCCACCAAGAGGCTGCTGCAGTTC
TATGCAGAGACCTGCCCAGCCCCCGAGCGCGGAGGTGCCGTGCGGGACCGGCTGCTACAGAGCAACCCGGTGCTGGAGGCCTTTGGAAAT
GCCAAGACCCTCCGGAACGATAACTCCAGCAGGTTCGGGAAGTACATGGATGTGCAGTTTGACTTCAAGGGTGCCCCCGTGGGTGGCCAC
ATCCTCAGTTACCTCCTGGAAAAGTCACGAGTGGTGCACCAGAATCATGGGGAGCGGAACTTCCACATCTTCTACCAGCTGCTGGAGGGG
GGTGAGGAGGAGACTCTTCGCAGGCTGGGCTTGGAACGGAACCCCCAGAGCTACCTGTACCTGGTGAAGGGCCAGTGTGCCAAAGTCTCC
TCCATCAACGACAAGAGTGACTGGAAGGTCGTCAGGAAGGCTCTGACAGTCATTGATTTCACCGAGGATGAAGTGGAGGACCTGCTGAGC
ATCGTGGCCAGCGTCCTTCATTTGGGCAACATCCACTTTGCTGCCAACGAGGAGAGCAATGCCCAGGTCACCACCGAGAACCAGCTCAAG
TATCTGACCAGGCTCCTCAGCGTGGAAGGCTCGACGCTGCGAGAAGCCCTGACACACAGGAAGATCATCGCCAAGGGGGAGGAGCTCCTG
AGCCCGCTGAACCTGGAGCAGGCCGCGTACGCACGAGACGCCCTCGCCAAGGCTGTGTACAGCCGCACTTTTACCTGGCTCGTCGGGAAG
ATCAACAGGTCGCTGGCCTCCAAGGAATCTGGCCAACTGTGAGCGCCTCATCGAAGTGGAGGACATGATGGTGATGGGCCGCAAGCCGGA
CCCCATGTGTGTCTTCACCTACGTCCAGTCGCTGTACAACCACCTGCGTCGCTTCGAGTAAAGCCCCTGAGCCTGGATTGCCAAAGAGCA
GCCCCAGGAAGAGGCCGGGGGTCCGCTTGCGATTCCCCAGCCAGGATGCCCCCAGGAGCCTTGCCGTTTGGTGTGAGCGCGCTGTTTGTT
CTGTGGCATGTGACGGCACTCCCCTTCGAGCCCAGCTGTGTTACTGATTAAAAGTACTGCTGAGCTGTGGTCCGACAGCACTGATCACAG
CCAAGGGCTTGGAGGAAAAGGAAAAATTATGAGAGAGAGAGAGACATTGGTGCTAAGTAATGATCTTCCTAAAGAAATGCTTGTGTTTAT
AGCTTCCAGAATGCTAATCTACAATTTTCCCTCTGGTGAATTCGATACATCGGCTTTACAGGGTTACAGTGATTACCAAGTGTTTTTTTT
TATCAAAATACCCAGAGTTTTTTACTTCCTCACGCGATTGTAGGTTCCTCTCCTCCCTCCCTCTGGGCCACTGCCAGGAAACAGAGAGAC
CGCTTAATCAGCAGCTTGACAAAGAAGACCTCAAGTCTTGGGAAGAAACAGTTTAATCACTCCCAAGTCCTGGGCAACAGATGACCTTCA
AGTCACCTCCGCTCTCCGGGGAGATGGGAAGGCTCTCCTCTCGGTCCCAAAGTCCTCCTGTTCTTCCCAGGAGGCCCCACAAGTGTTTGG
CTAAGCACAGGCTCTCGGGAATTTAACACTTTTGGGGAAGGAATAGGCCCTTTGTGCTGAGAGAGAGTTTTTATTCACATCTTTTTTAGG

>56638_56638_5_MYO1C-SMTNL2_MYO1C_chr17_1381910_ENST00000575158_SMTNL2_chr17_4510656_ENST00000389313_length(amino acids)=383AA_BP=
MGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHL
FAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQF
DFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF
TEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYO1C-SMTNL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO1C-SMTNL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO1C-SMTNL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource