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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO1D-FAIM3 (FusionGDB2 ID:56645)

Fusion Gene Summary for MYO1D-FAIM3

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1D-FAIM3
Fusion gene ID: 56645
HgeneTgene
Gene symbol

MYO1D

FAIM3

Gene ID

4642

9214

Gene namemyosin IDFc fragment of IgM receptor
SynonymsPPP1R108|myr4FAIM3|TOSO
Cytomap

17q11.2

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-Idmyosin-I gammaprotein phosphatase 1, regulatory subunit 108fas apoptotic inhibitory molecule 3Fc mu receptorIgM Fc fragment receptorIgM Fc receptorimmunoglobulin mu Fc receptorregulator of Fas-induced apoptosis Toso
Modification date2020031320200313
UniProtAcc

O94832

.
Ensembl transtripts involved in fusion geneENST00000318217, ENST00000394649, 
ENST00000579584, ENST00000583621, 
ENST00000584232, 		ENST00000420007, 
ENST00000528654, ENST00000442471, 
ENST00000367091, 
Fusion gene scores* DoF score24 X 17 X 12=48961 X 2 X 1=2
# samples 281
** MAII scorelog2(28/4896*10)=-4.12810482574769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: MYO1D [Title/Abstract] AND FAIM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO1D(30980861)-FAIM3(207078492), # samples:2
Anticipated loss of major functional domain due to fusion event.MYO1D-FAIM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO1D

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across MYO1D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAIM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04X-01AMYO1Dchr17

30980861

-FAIM3chr1

207078492

-
ChimerDB4BRCATCGA-A2-A04X-01AMYO1Dchr17

30980861

-FAIM3chr1

207087439

-


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Fusion Gene ORF analysis for MYO1D-FAIM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000318217ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
5CDS-5UTRENST00000318217ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
5CDS-5UTRENST00000394649ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
5CDS-5UTRENST00000394649ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
5CDS-5UTRENST00000579584ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
5CDS-5UTRENST00000579584ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
5CDS-intronENST00000318217ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000318217ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000318217ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000394649ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000394649ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000394649ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000579584ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000579584ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
5CDS-intronENST00000579584ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
Frame-shiftENST00000318217ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
Frame-shiftENST00000394649ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
Frame-shiftENST00000394649ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
Frame-shiftENST00000579584ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
In-frameENST00000318217ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
In-frameENST00000318217ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
In-frameENST00000394649ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
In-frameENST00000579584ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
In-frameENST00000579584ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-3CDSENST00000583621ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-3CDSENST00000583621ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
intron-3CDSENST00000583621ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-3CDSENST00000584232ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-3CDSENST00000584232ENST00000367091MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
intron-3CDSENST00000584232ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-5UTRENST00000583621ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-5UTRENST00000583621ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-5UTRENST00000584232ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-5UTRENST00000584232ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207078492

-
intron-intronENST00000583621ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
intron-intronENST00000583621ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
intron-intronENST00000583621ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
intron-intronENST00000584232ENST00000420007MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
intron-intronENST00000584232ENST00000442471MYO1Dchr17

30980861

-FAIM3chr1

207087439

-
intron-intronENST00000584232ENST00000528654MYO1Dchr17

30980861

-FAIM3chr1

207087439

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318217MYO1Dchr1730980861-ENST00000367091FAIM3chr1207078492-366229002843028914
ENST00000318217MYO1Dchr1730980861-ENST00000442471FAIM3chr1207078492-348929002843028914
ENST00000579584MYO1Dchr1730980861-ENST00000367091FAIM3chr1207078492-362928672512995914
ENST00000579584MYO1Dchr1730980861-ENST00000442471FAIM3chr1207078492-345628672512995914
ENST00000394649MYO1Dchr1730980861-ENST00000367091FAIM3chr1207087439-464428753672889840

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318217ENST00000367091MYO1Dchr1730980861-FAIM3chr1207078492-0.0017662360.9982338
ENST00000318217ENST00000442471MYO1Dchr1730980861-FAIM3chr1207078492-0.0020084390.99799156
ENST00000579584ENST00000367091MYO1Dchr1730980861-FAIM3chr1207078492-0.0016796680.9983203
ENST00000579584ENST00000442471MYO1Dchr1730980861-FAIM3chr1207078492-0.0019197770.99808025
ENST00000394649ENST00000367091MYO1Dchr1730980861-FAIM3chr1207087439-0.001000920.99899906

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Fusion Genomic Features for MYO1D-FAIM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO1D-FAIM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:30980861/chr1:207078492)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO1D

O94832

.
FUNCTION: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Dchr17:30980861chr1:207078492ENST00000318217-1922699_7198651007.0DomainIQ 1
HgeneMYO1Dchr17:30980861chr1:207078492ENST00000318217-1922721_7418651007.0DomainIQ 2
HgeneMYO1Dchr17:30980861chr1:207078492ENST00000318217-19229_6958651007.0DomainMyosin motor
HgeneMYO1Dchr17:30980861chr1:207087439ENST00000318217-1922699_7198651007.0DomainIQ 1
HgeneMYO1Dchr17:30980861chr1:207087439ENST00000318217-1922721_7418651007.0DomainIQ 2
HgeneMYO1Dchr17:30980861chr1:207087439ENST00000318217-19229_6958651007.0DomainMyosin motor
HgeneMYO1Dchr17:30980861chr1:207078492ENST00000318217-1922102_1098651007.0Nucleotide bindingATP
HgeneMYO1Dchr17:30980861chr1:207087439ENST00000318217-1922102_1098651007.0Nucleotide bindingATP
HgeneMYO1Dchr17:30980861chr1:207078492ENST00000318217-1922572_5948651007.0RegionActin-binding
HgeneMYO1Dchr17:30980861chr1:207087439ENST00000318217-1922572_5948651007.0RegionActin-binding
TgeneFAIM3chr17:30980861chr1:207078492ENST0000044247157274_323236279.0Compositional biasNote=Arg-rich
TgeneFAIM3chr17:30980861chr1:207087439ENST0000036709108274_32312391.0Compositional biasNote=Arg-rich
TgeneFAIM3chr17:30980861chr1:207087439ENST0000042000707274_32312307.0Compositional biasNote=Arg-rich
TgeneFAIM3chr17:30980861chr1:207087439ENST0000044247107274_3230279.0Compositional biasNote=Arg-rich
TgeneFAIM3chr17:30980861chr1:207087439ENST000003670910833_10512391.0DomainNote=Ig-like
TgeneFAIM3chr17:30980861chr1:207087439ENST000004200070733_10512307.0DomainNote=Ig-like
TgeneFAIM3chr17:30980861chr1:207087439ENST000004424710733_1050279.0DomainNote=Ig-like
TgeneFAIM3chr17:30980861chr1:207078492ENST0000044247157273_390236279.0Topological domainCytoplasmic
TgeneFAIM3chr17:30980861chr1:207087439ENST000003670910818_25112391.0Topological domainExtracellular
TgeneFAIM3chr17:30980861chr1:207087439ENST0000036709108273_39012391.0Topological domainCytoplasmic
TgeneFAIM3chr17:30980861chr1:207087439ENST000004200070718_25112307.0Topological domainExtracellular
TgeneFAIM3chr17:30980861chr1:207087439ENST0000042000707273_39012307.0Topological domainCytoplasmic
TgeneFAIM3chr17:30980861chr1:207087439ENST000004424710718_2510279.0Topological domainExtracellular
TgeneFAIM3chr17:30980861chr1:207087439ENST0000044247107273_3900279.0Topological domainCytoplasmic
TgeneFAIM3chr17:30980861chr1:207078492ENST0000044247157252_272236279.0TransmembraneHelical
TgeneFAIM3chr17:30980861chr1:207087439ENST0000036709108252_27212391.0TransmembraneHelical
TgeneFAIM3chr17:30980861chr1:207087439ENST0000042000707252_27212307.0TransmembraneHelical
TgeneFAIM3chr17:30980861chr1:207087439ENST0000044247107252_2720279.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Dchr17:30980861chr1:207078492ENST00000318217-1922812_10058651007.0DomainTH1
HgeneMYO1Dchr17:30980861chr1:207087439ENST00000318217-1922812_10058651007.0DomainTH1
TgeneFAIM3chr17:30980861chr1:207078492ENST0000036709168274_323348391.0Compositional biasNote=Arg-rich
TgeneFAIM3chr17:30980861chr1:207078492ENST0000042000757274_323304307.0Compositional biasNote=Arg-rich
TgeneFAIM3chr17:30980861chr1:207078492ENST000003670916833_105348391.0DomainNote=Ig-like
TgeneFAIM3chr17:30980861chr1:207078492ENST000004200075733_105304307.0DomainNote=Ig-like
TgeneFAIM3chr17:30980861chr1:207078492ENST000004424715733_105236279.0DomainNote=Ig-like
TgeneFAIM3chr17:30980861chr1:207078492ENST000003670916818_251348391.0Topological domainExtracellular
TgeneFAIM3chr17:30980861chr1:207078492ENST0000036709168273_390348391.0Topological domainCytoplasmic
TgeneFAIM3chr17:30980861chr1:207078492ENST000004200075718_251304307.0Topological domainExtracellular
TgeneFAIM3chr17:30980861chr1:207078492ENST0000042000757273_390304307.0Topological domainCytoplasmic
TgeneFAIM3chr17:30980861chr1:207078492ENST000004424715718_251236279.0Topological domainExtracellular
TgeneFAIM3chr17:30980861chr1:207078492ENST0000036709168252_272348391.0TransmembraneHelical
TgeneFAIM3chr17:30980861chr1:207078492ENST0000042000757252_272304307.0TransmembraneHelical


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Fusion Gene Sequence for MYO1D-FAIM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56645_56645_1_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000318217_FAIM3_chr1_207078492_ENST00000367091_length(transcript)=3662nt_BP=2900nt
AGGCTGGAGGCGGGACCAGCCGCTGCCGTCTCCGTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACT
GTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCCGAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGG
CGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGCGGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGC
CCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCGCCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACA
CCGTCTCCATGCCCGAGTTCATGGCCAACCTCAGGCTCAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTG
TGAACCCTTACAAGTTGTTGAACATCTATGGAAGAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTT
TTGCTATTGCGGATGCTGCTTACAAGGCTATGAAGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAA
CGGAAGCCAGTAAGTACATTATGCAGTATATTGCGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGC
TTAAGTCCAACTGTGTTTTGGAAGCTTTTGGAAATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCA
ACTTTGACTTCAAGGGTGACCCTATTGGTGGGCATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAA
GAAGCTTTCATTCTTTCTATCAGCTACTCCAAGGAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACA
ACTATATTCATGTGGGAGCTCAATTAAAGTCTTCTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCT
TCAAACCTGAGGAGATCCAAACAGTGTATAAGATTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGC
CTCTTATTGAGAATGGCAAAGTAGTATCTATCATAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGA
CTGTGGCCACAGGCCGTGACATCATTGACAAGCAGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATG
AGCGCCTTTTTTGTTGGATCGTTACTCGCATCAATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTA
TTGGTGTCTTGGATATCTATGGCTTTGAAATCTTTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGC
AGCTATTTATTCAGCTGGTTCTGAAGCAAGAACAAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATC
AGATCATTGTTGACCTCGTGGAGCAACAGCACAAAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATG
AAATGTTTCTTGAAGCACTTAACAGTAAATTGGGCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGT
TTGATCGAGATTTTCGAATTCGACATTATGCAGGCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTC
AAGATTTCAAGCGCCTTATGTATAACAGTTCAAATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCA
AGCGACCTCTGACTGCTGCTACCTTGTTTAAGAATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTT
GCATCAAACCCAATGACAAGAAATCTCCACAGATATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATG
TGAGAGTGCGTCGGGCAGGATTTGCCTTCCGCCAGACATACGAGAAGTTTCTTCACAGGTATAAGATGATCTCTGAATTCACCTGGCCCA
ACCATGACCTTCCTTCAGACAAAGAGGCTGTCAAGAAACTAATTGAACGGTGTGGTTTTCAGGATGATGTAGCTTATGGGAAGACCAAAA
TTTTCATTCGAACACCCCGAACATTGTTTACCTTGGAAGAACTCCGTGCCCAGATGCTCATAAGGATTGTCCTCTTTCTACAAAAGGTGT
GGCGGGGCACCCTGGCCCGCATGCGGTACAAAAGAACCAAGGCAGCTCTGACAATAATCAGGTACTACCGGCGCTACAAAGTGAAGTCGT
ACATCCACGAGGTGGCCAGACGCTTCCATGGCGTCAAGACCATGCGAGACTACGGGAAGCACGTGAAGTGGCCAAGCCCTCCTAAAGTTC
TTCGCCGTTTTGAGGAGGCCCTGCAGACGATTTTCAATAGATGGAGAGCATCCCAGCTCATCAAGAGCATTCCGGCCTCAGACCTGCCCC
AGGTCAGGGCAAAGGTTGCAGCCGTGGAAATGTTGAAGGGTCAAAGGGCTGACCTCGGGCTCCAGAGGGCCTGGGAGGGCAACTATCTTG
CTTCAAAGCCAGATACACCTCAGACCTCAGGCACTTTTGTCCCTGTTGCTAATGAATTGAAACGGAAGGACAAATACATGAATGTCCTCT
TTTCCTGTCACGTCCGTAAGGTGTCTGAATCTCCCTGGCTCCATGCCCCATCTCTGAAGACCAGCTGTGAATACGTGAGCCTCTACCACC
AGCCTGCCGCCATGATGGAGGACAGTGATTCAGATGACTACATCAATGTTCCTGCCTGACAACTCCCCAGCTATCCCCCAACCCCAGGCT
CGGACTGTGGTGCCAAGGAGTCTCATCTATCTGCTGATGTCCAATACCTGCTTCATGTGTTCTCAGAGCCCTCATCACTTCCCATGCCCC
ATCTCGACTCCCATCCCCATCTATCTGTGCCCTGAGCATGGCTCTGCCCCCAGGTCGTCTTGCACACCTTGGCAGCCCCCTGTAGTTGAC
AGGTAAGCTGTAGGCATGTAGAGCAATTGTCCCAATGCCACTTGCTTCCTTTCCAAGCCGTCGAACAGACTGTGGGATTTGCAGAGTGTT
TCTTCCATGTCTTTGACCACAGGGTTGTTGCTGCCCAGGCTCTAGATCACATGGCATCAGGCTGGGGCAGAGGCATAGCTATTGTCTCGG
GCATCCTTCCCAGGGTTGGGTCTTACACAAATAGAAGGCTCTTGCTCTGAGTTATGTGACATGCCTCAGCCCCATGGACTAAGCAGGGGT
CTGGTATAAAAACACTCCTGGAAACGCCTTTGCCCTGATCCAAATGTTAGCACTTGCTAGTGAACGTCTACTTATCTCAAGTTCTATGCT

>56645_56645_1_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000318217_FAIM3_chr1_207078492_ENST00000367091_length(amino acids)=914AA_BP=872
MSPRAGAMAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIAD
AAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFK
GDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEE
IQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFC
WIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVD
LVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKR
LMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRR
AGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTL
ARMRYKRTKAALTIIRYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVRAK
VAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVSESPWLHAPSLKTSCEYVSLYHQPAAM

--------------------------------------------------------------
>56645_56645_2_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000318217_FAIM3_chr1_207078492_ENST00000442471_length(transcript)=3489nt_BP=2900nt
AGGCTGGAGGCGGGACCAGCCGCTGCCGTCTCCGTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACT
GTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCCGAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGG
CGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGCGGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGC
CCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCGCCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACA
CCGTCTCCATGCCCGAGTTCATGGCCAACCTCAGGCTCAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTG
TGAACCCTTACAAGTTGTTGAACATCTATGGAAGAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTT
TTGCTATTGCGGATGCTGCTTACAAGGCTATGAAGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAA
CGGAAGCCAGTAAGTACATTATGCAGTATATTGCGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGC
TTAAGTCCAACTGTGTTTTGGAAGCTTTTGGAAATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCA
ACTTTGACTTCAAGGGTGACCCTATTGGTGGGCATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAA
GAAGCTTTCATTCTTTCTATCAGCTACTCCAAGGAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACA
ACTATATTCATGTGGGAGCTCAATTAAAGTCTTCTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCT
TCAAACCTGAGGAGATCCAAACAGTGTATAAGATTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGC
CTCTTATTGAGAATGGCAAAGTAGTATCTATCATAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGA
CTGTGGCCACAGGCCGTGACATCATTGACAAGCAGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATG
AGCGCCTTTTTTGTTGGATCGTTACTCGCATCAATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTA
TTGGTGTCTTGGATATCTATGGCTTTGAAATCTTTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGC
AGCTATTTATTCAGCTGGTTCTGAAGCAAGAACAAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATC
AGATCATTGTTGACCTCGTGGAGCAACAGCACAAAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATG
AAATGTTTCTTGAAGCACTTAACAGTAAATTGGGCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGT
TTGATCGAGATTTTCGAATTCGACATTATGCAGGCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTC
AAGATTTCAAGCGCCTTATGTATAACAGTTCAAATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCA
AGCGACCTCTGACTGCTGCTACCTTGTTTAAGAATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTT
GCATCAAACCCAATGACAAGAAATCTCCACAGATATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATG
TGAGAGTGCGTCGGGCAGGATTTGCCTTCCGCCAGACATACGAGAAGTTTCTTCACAGGTATAAGATGATCTCTGAATTCACCTGGCCCA
ACCATGACCTTCCTTCAGACAAAGAGGCTGTCAAGAAACTAATTGAACGGTGTGGTTTTCAGGATGATGTAGCTTATGGGAAGACCAAAA
TTTTCATTCGAACACCCCGAACATTGTTTACCTTGGAAGAACTCCGTGCCCAGATGCTCATAAGGATTGTCCTCTTTCTACAAAAGGTGT
GGCGGGGCACCCTGGCCCGCATGCGGTACAAAAGAACCAAGGCAGCTCTGACAATAATCAGGTACTACCGGCGCTACAAAGTGAAGTCGT
ACATCCACGAGGTGGCCAGACGCTTCCATGGCGTCAAGACCATGCGAGACTACGGGAAGCACGTGAAGTGGCCAAGCCCTCCTAAAGTTC
TTCGCCGTTTTGAGGAGGCCCTGCAGACGATTTTCAATAGATGGAGAGCATCCCAGCTCATCAAGAGCATTCCGGCCTCAGACCTGCCCC
AGGTCAGGGCAAAGGTTGCAGCCGTGGAAATGTTGAAGGGTCAAAGGGCTGACCTCGGGCTCCAGAGGGCCTGGGAGGGCAACTATCTTG
CTTCAAAGCCAGATACACCTCAGACCTCAGGCACTTTTGTCCCTGTTGCTAATGAATTGAAACGGAAGGACAAATACATGAATGTCCTCT
TTTCCTGTCACGTCCGTAAGGTGTCTGAATCTCCCTGGCTCCATGCCCCATCTCTGAAGACCAGCTGTGAATACGTGAGCCTCTACCACC
AGCCTGCCGCCATGATGGAGGACAGTGATTCAGATGACTACATCAATGTTCCTGCCTGACAACTCCCCAGCTATCCCCCAACCCCAGGCT
CGGACTGTGGTGCCAAGGAGTCTCATCTATCTGCTGATGTCCAATACCTGCTTCATGTGTTCTCAGAGCCCTCATCACTTCCCATGCCCC
ATCTCGACTCCCATCCCCATCTATCTGTGCCCTGAGCATGGCTCTGCCCCCAGGTCGTCTTGCACACCTTGGCAGCCCCCTGTAGTTGAC
AGGTAAGCTGTAGGCATGTAGAGCAATTGTCCCAATGCCACTTGCTTCCTTTCCAAGCCGTCGAACAGACTGTGGGATTTGCAGAGTGTT
TCTTCCATGTCTTTGACCACAGGGTTGTTGCTGCCCAGGCTCTAGATCACATGGCATCAGGCTGGGGCAGAGGCATAGCTATTGTCTCGG

>56645_56645_2_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000318217_FAIM3_chr1_207078492_ENST00000442471_length(amino acids)=914AA_BP=872
MSPRAGAMAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIAD
AAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFK
GDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEE
IQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFC
WIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVD
LVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKR
LMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRR
AGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTL
ARMRYKRTKAALTIIRYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVRAK
VAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVSESPWLHAPSLKTSCEYVSLYHQPAAM

--------------------------------------------------------------
>56645_56645_3_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000394649_FAIM3_chr1_207087439_ENST00000367091_length(transcript)=4644nt_BP=2875nt
TTCTTCAACTTCTTGATTTACCCTAGGCTGGGGTTCCCAAATCCAGCTTTGTGTCATGATCACCCAGCTTTTAAAATACGCAGATTCCCC
GGACTCTGTCTTCTGGAGATGGTGATTTATTAAGCCTCCTTAGTGCCCAGCTCAAATGAAGAAATATTGCACCAGAAGAAGAAAGCCAAG
AAATGAAGTCACAACGTCAGTCATTTAATCCACCACCTGTGGTCCTAACTAGTTCTTATGTCCTGTGGAACACACAGTCTAACAAGGGGA
TAAAACTAATTGACTCCATCACATGGAAACCATGATTTTTGCCAAGAGAAGCAGAAACAAGATGCTTTCACCCTTGGGAGAGATTCTCAT
CTAAGAACTGGCAAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTGTGAACCCTTACAAGTTGTTGAACAT
CTATGGAAGAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTTTTGCTATTGCGGATGCTGCTTACAA
GGCTATGAAGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAACGGAAGCCAGTAAGTACATTATGCA
GTATATTGCGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGCTTAAGTCCAACTGTGTTTTGGAAGC
TTTTGGAAATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCAACTTTGACTTCAAGGGTGACCCTAT
TGGTGGGCATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAAGAAGCTTTCATTCTTTCTATCAGCT
ACTCCAAGGAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACAACTATATTCATGTGGGAGCTCAATT
AAAGTCTTCTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCTTCAAACCTGAGGAGATCCAAACAGT
GTATAAGATTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGCCTCTTATTGAGAATGGCAAAGTAGT
ATCTATCATAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGACTGTGGCCACAGGCCGTGACATCAT
TGACAAGCAGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATGAGCGCCTTTTTTGTTGGATCGTTAC
TCGCATCAATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTATTGGTGTCTTGGATATCTATGGCTT
TGAAATCTTTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGCAGCTATTTATTCAGCTGGTTCTGAA
GCAAGAACAAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATCAGATCATTGTTGACCTCGTGGAGCA
ACAGCACAAAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATGAAATGTTTCTTGAAGCACTTAACAG
TAAATTGGGCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGTTTGATCGAGATTTTCGAATTCGACA
TTATGCAGGCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTCAAGATTTCAAGCGCCTTATGTATAA
CAGTTCAAATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCAAGCGACCTCTGACTGCTGCTACCTT
GTTTAAGAATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTTGCATCAAACCCAATGACAAGAAATC
TCCACAGATATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATGTGAGAGTGCGTCGGGCAGGATTTGC
CTTCCGCCAGACATACGAGAAGTTTCTTCACAGGTATAAGATGATCTCTGAATTCACCTGGCCCAACCATGACCTTCCTTCAGACAAAGA
GGCTGTCAAGAAACTAATTGAACGGTGTGGTTTTCAGGATGATGTAGCTTATGGGAAGACCAAAATTTTCATTCGAACACCCCGAACATT
GTTTACCTTGGAAGAACTCCGTGCCCAGATGCTCATAAGGATTGTCCTCTTTCTACAAAAGGTGTGGCGGGGCACCCTGGCCCGCATGCG
GTACAAAAGAACCAAGGCAGCTCTGACAATAATCAGGTACTACCGGCGCTACAAAGTGAAGTCGTACATCCACGAGGTGGCCAGACGCTT
CCATGGCGTCAAGACCATGCGAGACTACGGGAAGCACGTGAAGTGGCCAAGCCCTCCTAAAGTTCTTCGCCGTTTTGAGGAGGCCCTGCA
GACGATTTTCAATAGATGGAGAGCATCCCAGCTCATCAAGAGCATTCCGGCCTCAGACCTGCCCCAGGTCAGGGCAAAGGTTGCAGCCGT
GGAAATGTTGAAGGGTCAAAGGGCTGACCTCGGGCTCCAGAGGGCCTGGGAGGGCAACTATCTTGCTTCAAAGCCAGATACACCTCAGAC
CTCAGGCACTTTTGTCCCTGTTGCTAATGAATTGAAACGGAAGGACAAATACATGAATGTCCTCTTTTCCTGTCACGTCCGTAAGTATCG
GGGGCCCTGAGGATCCTCCCAGAAGTAAAGGTAGAGGGGGAGCTGGGCGGATCAGTTACCATCAAGTGCCCACTTCCTGAAATGCATGTG
AGGATATATCTGTGCCGGGAGATGGCTGGATCTGGAACATGTGGTACCGTGGTATCCACCACCAACTTCATCAAGGCAGAATACAAGGGC
CGAGTTACTCTGAAGCAATACCCACGCAAGAATCTGTTCCTAGTGGAGGTAACACAGCTGACAGAAAGTGACAGCGGAGTCTATGCCTGC
GGAGCGGGCATGAACACAGACCGGGGAAAGACCCAGAAAGTCACCCTGAATGTCCACAGTGAATACGAGCCATCATGGGAAGAGCAGCCA
ATGCCTGAGACTCCAAAATGGTTTCATCTGCCCTATTTGTTCCAGATGCCTGCATATGCCAGTTCTTCCAAATTCGTAACCAGAGTTACC
ACACCAGCTCAAAGGGGCAAGGTCCCTCCAGTTCACCACTCCTCCCCCACCACCCAAATCACCCACCGCCCTCGAGTGTCCAGAGCATCT
TCAGTAGCAGGTGACAAGCCCCGAACCTTCCTGCCATCCACTACAGCCTCAAAAATCTCAGCTCTGGAGGGGCTGCTCAAGCCCCAGACG
CCCAGCTACAACCACCACACCAGGCTGCACAGGCAGAGAGCACTGGACTATGGCTCACAGTCTGGGAGGGAAGGCCAAGGATTTCACATC
CTGATCCCGACCATCCTGGGCCTTTTCCTGCTGGCACTTCTGGGGCTGGTGGTGAAAAGGGCCGTTGAAAGGAGGAAAGCCCTCTCCAGG
CGGGCCCGCCGACTGGCCGTGAGGATGCGCGCCCTGGAGAGCTCCCAGAGGCCCCGCGGGTCGCCGCGACCGCGCTCCCAAAACAACATC
TACAGCGCCTGCCCGCGGCGCGCTCGTGGAGCGGACGCTGCAGGCACAGGGGAGGCCCCCGTTCCCGGCCCCGGAGCGCCGTTGCCCCCC
GCCCCGCTGCAGGTGTCTGAATCTCCCTGGCTCCATGCCCCATCTCTGAAGACCAGCTGTGAATACGTGAGCCTCTACCACCAGCCTGCC
GCCATGATGGAGGACAGTGATTCAGATGACTACATCAATGTTCCTGCCTGACAACTCCCCAGCTATCCCCCAACCCCAGGCTCGGACTGT
GGTGCCAAGGAGTCTCATCTATCTGCTGATGTCCAATACCTGCTTCATGTGTTCTCAGAGCCCTCATCACTTCCCATGCCCCATCTCGAC
TCCCATCCCCATCTATCTGTGCCCTGAGCATGGCTCTGCCCCCAGGTCGTCTTGCACACCTTGGCAGCCCCCTGTAGTTGACAGGTAAGC
TGTAGGCATGTAGAGCAATTGTCCCAATGCCACTTGCTTCCTTTCCAAGCCGTCGAACAGACTGTGGGATTTGCAGAGTGTTTCTTCCAT
GTCTTTGACCACAGGGTTGTTGCTGCCCAGGCTCTAGATCACATGGCATCAGGCTGGGGCAGAGGCATAGCTATTGTCTCGGGCATCCTT
CCCAGGGTTGGGTCTTACACAAATAGAAGGCTCTTGCTCTGAGTTATGTGACATGCCTCAGCCCCATGGACTAAGCAGGGGTCTGGTATA
AAAACACTCCTGGAAACGCCTTTGCCCTGATCCAAATGTTAGCACTTGCTAGTGAACGTCTACTTATCTCAAGTTCTATGCTAAAGGCAA

>56645_56645_3_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000394649_FAIM3_chr1_207087439_ENST00000367091_length(amino acids)=840AA_BP=
MARFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYI
AAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQ
GGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSI
IAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEI
FDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKL
GKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFK
NSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAV
KKLIERCGFQDDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMRYKRTKAALTIIRYYRRYKVKSYIHEVARRFHG
VKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVRAKVAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSG

--------------------------------------------------------------
>56645_56645_4_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000579584_FAIM3_chr1_207078492_ENST00000367091_length(transcript)=3629nt_BP=2867nt
GTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACTGTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCC
GAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGGCGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGC
GGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGCCCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCG
CCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACACCGTCTCCATGCCCGAGTTCATGGCCAACCTCA
GGCTCAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTGTGAACCCTTACAAGTTGTTGAACATCTATGGAA
GAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTTTTGCTATTGCGGATGCTGCTTACAAGGCTATGA
AGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAACGGAAGCCAGTAAGTACATTATGCAGTATATTG
CGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGCTTAAGTCCAACTGTGTTTTGGAAGCTTTTGGAA
ATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCAACTTTGACTTCAAGGGTGACCCTATTGGTGGGC
ATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAAGAAGCTTTCATTCTTTCTATCAGCTACTCCAAG
GAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACAACTATATTCATGTGGGAGCTCAATTAAAGTCTT
CTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCTTCAAACCTGAGGAGATCCAAACAGTGTATAAGA
TTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGCCTCTTATTGAGAATGGCAAAGTAGTATCTATCA
TAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGACTGTGGCCACAGGCCGTGACATCATTGACAAGC
AGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATGAGCGCCTTTTTTGTTGGATCGTTACTCGCATCA
ATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTATTGGTGTCTTGGATATCTATGGCTTTGAAATCT
TTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGCAGCTATTTATTCAGCTGGTTCTGAAGCAAGAAC
AAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATCAGATCATTGTTGACCTCGTGGAGCAACAGCACA
AAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATGAAATGTTTCTTGAAGCACTTAACAGTAAATTGG
GCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGTTTGATCGAGATTTTCGAATTCGACATTATGCAG
GCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTCAAGATTTCAAGCGCCTTATGTATAACAGTTCAA
ATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCAAGCGACCTCTGACTGCTGCTACCTTGTTTAAGA
ATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTTGCATCAAACCCAATGACAAGAAATCTCCACAGA
TATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATGTGAGAGTGCGTCGGGCAGGATTTGCCTTCCGCC
AGACATACGAGAAGTTTCTTCACAGGTATAAGATGATCTCTGAATTCACCTGGCCCAACCATGACCTTCCTTCAGACAAAGAGGCTGTCA
AGAAACTAATTGAACGGTGTGGTTTTCAGGATGATGTAGCTTATGGGAAGACCAAAATTTTCATTCGAACACCCCGAACATTGTTTACCT
TGGAAGAACTCCGTGCCCAGATGCTCATAAGGATTGTCCTCTTTCTACAAAAGGTGTGGCGGGGCACCCTGGCCCGCATGCGGTACAAAA
GAACCAAGGCAGCTCTGACAATAATCAGGTACTACCGGCGCTACAAAGTGAAGTCGTACATCCACGAGGTGGCCAGACGCTTCCATGGCG
TCAAGACCATGCGAGACTACGGGAAGCACGTGAAGTGGCCAAGCCCTCCTAAAGTTCTTCGCCGTTTTGAGGAGGCCCTGCAGACGATTT
TCAATAGATGGAGAGCATCCCAGCTCATCAAGAGCATTCCGGCCTCAGACCTGCCCCAGGTCAGGGCAAAGGTTGCAGCCGTGGAAATGT
TGAAGGGTCAAAGGGCTGACCTCGGGCTCCAGAGGGCCTGGGAGGGCAACTATCTTGCTTCAAAGCCAGATACACCTCAGACCTCAGGCA
CTTTTGTCCCTGTTGCTAATGAATTGAAACGGAAGGACAAATACATGAATGTCCTCTTTTCCTGTCACGTCCGTAAGGTGTCTGAATCTC
CCTGGCTCCATGCCCCATCTCTGAAGACCAGCTGTGAATACGTGAGCCTCTACCACCAGCCTGCCGCCATGATGGAGGACAGTGATTCAG
ATGACTACATCAATGTTCCTGCCTGACAACTCCCCAGCTATCCCCCAACCCCAGGCTCGGACTGTGGTGCCAAGGAGTCTCATCTATCTG
CTGATGTCCAATACCTGCTTCATGTGTTCTCAGAGCCCTCATCACTTCCCATGCCCCATCTCGACTCCCATCCCCATCTATCTGTGCCCT
GAGCATGGCTCTGCCCCCAGGTCGTCTTGCACACCTTGGCAGCCCCCTGTAGTTGACAGGTAAGCTGTAGGCATGTAGAGCAATTGTCCC
AATGCCACTTGCTTCCTTTCCAAGCCGTCGAACAGACTGTGGGATTTGCAGAGTGTTTCTTCCATGTCTTTGACCACAGGGTTGTTGCTG
CCCAGGCTCTAGATCACATGGCATCAGGCTGGGGCAGAGGCATAGCTATTGTCTCGGGCATCCTTCCCAGGGTTGGGTCTTACACAAATA
GAAGGCTCTTGCTCTGAGTTATGTGACATGCCTCAGCCCCATGGACTAAGCAGGGGTCTGGTATAAAAACACTCCTGGAAACGCCTTTGC
CCTGATCCAAATGTTAGCACTTGCTAGTGAACGTCTACTTATCTCAAGTTCTATGCTAAAGGCAATTTATCTTGATGTGATGATAAACCA

>56645_56645_4_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000579584_FAIM3_chr1_207078492_ENST00000367091_length(amino acids)=914AA_BP=872
MSPRAGAMAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIAD
AAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFK
GDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEE
IQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFC
WIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVD
LVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKR
LMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRR
AGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTL
ARMRYKRTKAALTIIRYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVRAK
VAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVSESPWLHAPSLKTSCEYVSLYHQPAAM

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>56645_56645_5_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000579584_FAIM3_chr1_207078492_ENST00000442471_length(transcript)=3456nt_BP=2867nt
GTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACTGTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCC
GAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGGCGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGC
GGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGCCCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCG
CCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACACCGTCTCCATGCCCGAGTTCATGGCCAACCTCA
GGCTCAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTGTGAACCCTTACAAGTTGTTGAACATCTATGGAA
GAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTTTTGCTATTGCGGATGCTGCTTACAAGGCTATGA
AGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAACGGAAGCCAGTAAGTACATTATGCAGTATATTG
CGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGCTTAAGTCCAACTGTGTTTTGGAAGCTTTTGGAA
ATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCAACTTTGACTTCAAGGGTGACCCTATTGGTGGGC
ATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAAGAAGCTTTCATTCTTTCTATCAGCTACTCCAAG
GAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACAACTATATTCATGTGGGAGCTCAATTAAAGTCTT
CTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCTTCAAACCTGAGGAGATCCAAACAGTGTATAAGA
TTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGCCTCTTATTGAGAATGGCAAAGTAGTATCTATCA
TAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGACTGTGGCCACAGGCCGTGACATCATTGACAAGC
AGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATGAGCGCCTTTTTTGTTGGATCGTTACTCGCATCA
ATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTATTGGTGTCTTGGATATCTATGGCTTTGAAATCT
TTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGCAGCTATTTATTCAGCTGGTTCTGAAGCAAGAAC
AAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATCAGATCATTGTTGACCTCGTGGAGCAACAGCACA
AAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATGAAATGTTTCTTGAAGCACTTAACAGTAAATTGG
GCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGTTTGATCGAGATTTTCGAATTCGACATTATGCAG
GCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTCAAGATTTCAAGCGCCTTATGTATAACAGTTCAA
ATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCAAGCGACCTCTGACTGCTGCTACCTTGTTTAAGA
ATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTTGCATCAAACCCAATGACAAGAAATCTCCACAGA
TATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATGTGAGAGTGCGTCGGGCAGGATTTGCCTTCCGCC
AGACATACGAGAAGTTTCTTCACAGGTATAAGATGATCTCTGAATTCACCTGGCCCAACCATGACCTTCCTTCAGACAAAGAGGCTGTCA
AGAAACTAATTGAACGGTGTGGTTTTCAGGATGATGTAGCTTATGGGAAGACCAAAATTTTCATTCGAACACCCCGAACATTGTTTACCT
TGGAAGAACTCCGTGCCCAGATGCTCATAAGGATTGTCCTCTTTCTACAAAAGGTGTGGCGGGGCACCCTGGCCCGCATGCGGTACAAAA
GAACCAAGGCAGCTCTGACAATAATCAGGTACTACCGGCGCTACAAAGTGAAGTCGTACATCCACGAGGTGGCCAGACGCTTCCATGGCG
TCAAGACCATGCGAGACTACGGGAAGCACGTGAAGTGGCCAAGCCCTCCTAAAGTTCTTCGCCGTTTTGAGGAGGCCCTGCAGACGATTT
TCAATAGATGGAGAGCATCCCAGCTCATCAAGAGCATTCCGGCCTCAGACCTGCCCCAGGTCAGGGCAAAGGTTGCAGCCGTGGAAATGT
TGAAGGGTCAAAGGGCTGACCTCGGGCTCCAGAGGGCCTGGGAGGGCAACTATCTTGCTTCAAAGCCAGATACACCTCAGACCTCAGGCA
CTTTTGTCCCTGTTGCTAATGAATTGAAACGGAAGGACAAATACATGAATGTCCTCTTTTCCTGTCACGTCCGTAAGGTGTCTGAATCTC
CCTGGCTCCATGCCCCATCTCTGAAGACCAGCTGTGAATACGTGAGCCTCTACCACCAGCCTGCCGCCATGATGGAGGACAGTGATTCAG
ATGACTACATCAATGTTCCTGCCTGACAACTCCCCAGCTATCCCCCAACCCCAGGCTCGGACTGTGGTGCCAAGGAGTCTCATCTATCTG
CTGATGTCCAATACCTGCTTCATGTGTTCTCAGAGCCCTCATCACTTCCCATGCCCCATCTCGACTCCCATCCCCATCTATCTGTGCCCT
GAGCATGGCTCTGCCCCCAGGTCGTCTTGCACACCTTGGCAGCCCCCTGTAGTTGACAGGTAAGCTGTAGGCATGTAGAGCAATTGTCCC
AATGCCACTTGCTTCCTTTCCAAGCCGTCGAACAGACTGTGGGATTTGCAGAGTGTTTCTTCCATGTCTTTGACCACAGGGTTGTTGCTG
CCCAGGCTCTAGATCACATGGCATCAGGCTGGGGCAGAGGCATAGCTATTGTCTCGGGCATCCTTCCCAGGGTTGGGTCTTACACAAATA

>56645_56645_5_MYO1D-FAIM3_MYO1D_chr17_30980861_ENST00000579584_FAIM3_chr1_207078492_ENST00000442471_length(amino acids)=914AA_BP=872
MSPRAGAMAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIAD
AAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFK
GDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEE
IQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFC
WIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVD
LVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKR
LMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRR
AGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWRGTL
ARMRYKRTKAALTIIRYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVRAK
VAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVSESPWLHAPSLKTSCEYVSLYHQPAAM

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Fusion Gene PPI Analysis for MYO1D-FAIM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO1D-FAIM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO1D-FAIM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource