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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO1D-HNF1B (FusionGDB2 ID:56647)

Fusion Gene Summary for MYO1D-HNF1B

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1D-HNF1B
Fusion gene ID: 56647
HgeneTgene
Gene symbol

MYO1D

HNF1B

Gene ID

4642

6928

Gene namemyosin IDHNF1 homeobox B
SynonymsPPP1R108|myr4FJHN|HNF-1-beta|HNF-1B|HNF1beta|HNF2|HPC11|LF-B3|LFB3|MODY5|TCF-2|TCF2|VHNF1
Cytomap

17q11.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-Idmyosin-I gammaprotein phosphatase 1, regulatory subunit 108hepatocyte nuclear factor 1-betaHNF1 beta Ahomeoprotein LFB3transcription factor 2, hepatic
Modification date2020031320200313
UniProtAcc

O94832

P35680

Ensembl transtripts involved in fusion geneENST00000318217, ENST00000579584, 
ENST00000394649, ENST00000583621, 
ENST00000584232, 		ENST00000225893, 
ENST00000427275, ENST00000560016, 
ENST00000561193, 
Fusion gene scores* DoF score24 X 17 X 12=489612 X 10 X 8=960
# samples 2812
** MAII scorelog2(28/4896*10)=-4.12810482574769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/960*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO1D [Title/Abstract] AND HNF1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO1D(31048041)-HNF1B(36065056), # samples:2
Anticipated loss of major functional domain due to fusion event.MYO1D-HNF1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MYO1D-HNF1B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MYO1D-HNF1B seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO1D

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneHNF1B

GO:0001822

kidney development

21281489

TgeneHNF1B

GO:0045893

positive regulation of transcription, DNA-templated

16297991|21281489

TgeneHNF1B

GO:0060261

positive regulation of transcription initiation from RNA polymerase II promoter

15355349


check buttonFusion gene breakpoints across MYO1D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HNF1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CHOLTCGA-W5-AA31-01AMYO1Dchr17

31048041

-HNF1Bchr17

36065056

-


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Fusion Gene ORF analysis for MYO1D-HNF1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000318217ENST00000225893MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
Frame-shiftENST00000318217ENST00000427275MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
Frame-shiftENST00000318217ENST00000560016MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
Frame-shiftENST00000318217ENST00000561193MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
Frame-shiftENST00000579584ENST00000225893MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
Frame-shiftENST00000579584ENST00000427275MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
Frame-shiftENST00000579584ENST00000560016MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
Frame-shiftENST00000579584ENST00000561193MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
In-frameENST00000394649ENST00000225893MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
In-frameENST00000394649ENST00000427275MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
In-frameENST00000394649ENST00000560016MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
In-frameENST00000394649ENST00000561193MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000583621ENST00000225893MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000583621ENST00000427275MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000583621ENST00000560016MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000583621ENST00000561193MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000584232ENST00000225893MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000584232ENST00000427275MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000584232ENST00000560016MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-
intron-3CDSENST00000584232ENST00000561193MYO1Dchr17

31048041

-HNF1Bchr17

36065056

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394649MYO1Dchr1731048041-ENST00000225893HNF1Bchr1736065056-360121933672235622
ENST00000394649MYO1Dchr1731048041-ENST00000561193HNF1Bchr1736065056-286121933672235622
ENST00000394649MYO1Dchr1731048041-ENST00000560016HNF1Bchr1736065056-267221933672235622
ENST00000394649MYO1Dchr1731048041-ENST00000427275HNF1Bchr1736065056-247721933672235622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394649ENST00000225893MYO1Dchr1731048041-HNF1Bchr1736065056-0.0012098710.9987902
ENST00000394649ENST00000561193MYO1Dchr1731048041-HNF1Bchr1736065056-0.0014349340.99856514
ENST00000394649ENST00000560016MYO1Dchr1731048041-HNF1Bchr1736065056-0.0013828990.99861705
ENST00000394649ENST00000427275MYO1Dchr1731048041-HNF1Bchr1736065056-0.0008598760.99914014

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Fusion Genomic Features for MYO1D-HNF1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO1D-HNF1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:31048041/chr17:36065056)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO1D

O94832

HNF1B

P35680

FUNCTION: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}.FUNCTION: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Dchr17:31048041chr17:36065056ENST00000318217-1522102_1096371007.0Nucleotide bindingATP
HgeneMYO1Dchr17:31048041chr17:36065056ENST00000318217-1522572_5946371007.0RegionActin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Dchr17:31048041chr17:36065056ENST00000318217-1522699_7196371007.0DomainIQ 1
HgeneMYO1Dchr17:31048041chr17:36065056ENST00000318217-1522721_7416371007.0DomainIQ 2
HgeneMYO1Dchr17:31048041chr17:36065056ENST00000318217-1522812_10056371007.0DomainTH1
HgeneMYO1Dchr17:31048041chr17:36065056ENST00000318217-15229_6956371007.0DomainMyosin motor
TgeneHNF1Bchr17:31048041chr17:36065056ENST0000022589349231_311402558.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr17:31048041chr17:36065056ENST0000042727547231_311376458.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr17:31048041chr17:36065056ENST0000056119349231_311376532.0DNA bindingHomeobox%3B HNF1-type
TgeneHNF1Bchr17:31048041chr17:36065056ENST00000225893491_32402558.0DomainHNF-p1
TgeneHNF1Bchr17:31048041chr17:36065056ENST000002258934993_188402558.0DomainPOU-specific atypical
TgeneHNF1Bchr17:31048041chr17:36065056ENST00000427275471_32376458.0DomainHNF-p1
TgeneHNF1Bchr17:31048041chr17:36065056ENST000004272754793_188376458.0DomainPOU-specific atypical
TgeneHNF1Bchr17:31048041chr17:36065056ENST00000561193491_32376532.0DomainHNF-p1
TgeneHNF1Bchr17:31048041chr17:36065056ENST000005611934993_188376532.0DomainPOU-specific atypical
TgeneHNF1Bchr17:31048041chr17:36065056ENST00000225893491_31402558.0RegionDimerization
TgeneHNF1Bchr17:31048041chr17:36065056ENST00000427275471_31376458.0RegionDimerization
TgeneHNF1Bchr17:31048041chr17:36065056ENST00000561193491_31376532.0RegionDimerization


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Fusion Gene Sequence for MYO1D-HNF1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56647_56647_1_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000225893_length(transcript)=3601nt_BP=2193nt
TTCTTCAACTTCTTGATTTACCCTAGGCTGGGGTTCCCAAATCCAGCTTTGTGTCATGATCACCCAGCTTTTAAAATACGCAGATTCCCC
GGACTCTGTCTTCTGGAGATGGTGATTTATTAAGCCTCCTTAGTGCCCAGCTCAAATGAAGAAATATTGCACCAGAAGAAGAAAGCCAAG
AAATGAAGTCACAACGTCAGTCATTTAATCCACCACCTGTGGTCCTAACTAGTTCTTATGTCCTGTGGAACACACAGTCTAACAAGGGGA
TAAAACTAATTGACTCCATCACATGGAAACCATGATTTTTGCCAAGAGAAGCAGAAACAAGATGCTTTCACCCTTGGGAGAGATTCTCAT
CTAAGAACTGGCAAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTGTGAACCCTTACAAGTTGTTGAACAT
CTATGGAAGAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTTTTGCTATTGCGGATGCTGCTTACAA
GGCTATGAAGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAACGGAAGCCAGTAAGTACATTATGCA
GTATATTGCGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGCTTAAGTCCAACTGTGTTTTGGAAGC
TTTTGGAAATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCAACTTTGACTTCAAGGGTGACCCTAT
TGGTGGGCATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAAGAAGCTTTCATTCTTTCTATCAGCT
ACTCCAAGGAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACAACTATATTCATGTGGGAGCTCAATT
AAAGTCTTCTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCTTCAAACCTGAGGAGATCCAAACAGT
GTATAAGATTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGCCTCTTATTGAGAATGGCAAAGTAGT
ATCTATCATAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGACTGTGGCCACAGGCCGTGACATCAT
TGACAAGCAGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATGAGCGCCTTTTTTGTTGGATCGTTAC
TCGCATCAATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTATTGGTGTCTTGGATATCTATGGCTT
TGAAATCTTTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGCAGCTATTTATTCAGCTGGTTCTGAA
GCAAGAACAAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATCAGATCATTGTTGACCTCGTGGAGCA
ACAGCACAAAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATGAAATGTTTCTTGAAGCACTTAACAG
TAAATTGGGCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGTTTGATCGAGATTTTCGAATTCGACA
TTATGCAGGCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTCAAGATTTCAAGCGCCTTATGTATAA
CAGTTCAAATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCAAGCGACCTCTGACTGCTGCTACCTT
GTTTAAGAATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTTGCATCAAACCCAATGACAAGAAATC
TCCACAGATATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATGTGAGAGTGCGTCGGGCAGGATTTGC
CTTCCGCCAGACATACGAGAAGTTTCTTCACAGATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCCACAGC
CTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAAGCCTCAACACCTCC
CAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCAGCCCGTCCAGTTCTCCCAGCAGCTGCACAGCCCT
CACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTTCATGGCAGCTGTGACTCAGCTGCAGAACTCACAC
ATGTACGCACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATCTGCAATGGTGGTCACAGATACCAGCAGCATCAGT
ACACTCACCAACATGTCTTCAAGTAAACAGTGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGAC
CCTGTTTTCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTGCGAGAGGTCCCTGCTTACCTGA
CGGACGTCCTGCTGGCACCTCAGACAATCCACTCTCAGGAGGCGCAGCCCGAAGCCCAGTTTCCCTTCTATGCAGTATTGCCACAATGCC
TCTCCCACGATGTCAAGGACTCCTGTCTGTCCTGGAGGTGGGAGACAAGGAACCACCGAAGAGGAAGCAAGAAAGCCGTACTGTCTATGT
TGTGATCCTTCATCGAACAAACTGATGCGAAAACTTGAATCTGTTACTGAAATGAGGAGAGAAGGACATGTGCTATTGAACTGAGCCAAA
CACACTGTAAATATCCACAGACTCCCTCCCCTGCCCCCATCCCACATGATCTTGAGATTTCTTTTAAAGAAGTAAATTTGTCCAATGGCT
GTAAACTATAAACTACTGTAATTAAGTGCAATTTCCCCTCTGTGTCCTCTCCCCTCTGCCCTGTATATAATACTAAAGTGTCTATTAGTT
TTCTTTGTAAAGGTCAGAGTCAAAATTTCAAAAGTGATCTGTCCCCTCTCCCCTCATGGAGAAACATCCTAAGTGGGAAGTGAAGCCCCT
TGTCCTCTCCCGCGGGCCTGGACACTTATGGGGACAGCATACCTTGGACTGACTACCAGCTAACTCCAGTCTCCTGACATTAAGACACAC
CTCTGGATCCCTGGAGGGGCTGAATGTAGTGTGTCAGAGTAACATGCCAGCTTCCTGTGGGCCAGGAGCTCAGCCGTGCACTCCCTAAGA
AACCCCAGGGCAGGGAAACTGGCTGTTTGATAGCAGAAGAAAAAGTTGCAGTCTCAGAAAGCCTTCCATTAAAACAATTTATTTTATCAC

>56647_56647_1_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000225893_length(amino acids)=622AA_BP=
MARFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYI
AAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQ
GGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSI
IAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEI
FDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKL
GKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFK

--------------------------------------------------------------
>56647_56647_2_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000427275_length(transcript)=2477nt_BP=2193nt
TTCTTCAACTTCTTGATTTACCCTAGGCTGGGGTTCCCAAATCCAGCTTTGTGTCATGATCACCCAGCTTTTAAAATACGCAGATTCCCC
GGACTCTGTCTTCTGGAGATGGTGATTTATTAAGCCTCCTTAGTGCCCAGCTCAAATGAAGAAATATTGCACCAGAAGAAGAAAGCCAAG
AAATGAAGTCACAACGTCAGTCATTTAATCCACCACCTGTGGTCCTAACTAGTTCTTATGTCCTGTGGAACACACAGTCTAACAAGGGGA
TAAAACTAATTGACTCCATCACATGGAAACCATGATTTTTGCCAAGAGAAGCAGAAACAAGATGCTTTCACCCTTGGGAGAGATTCTCAT
CTAAGAACTGGCAAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTGTGAACCCTTACAAGTTGTTGAACAT
CTATGGAAGAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTTTTGCTATTGCGGATGCTGCTTACAA
GGCTATGAAGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAACGGAAGCCAGTAAGTACATTATGCA
GTATATTGCGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGCTTAAGTCCAACTGTGTTTTGGAAGC
TTTTGGAAATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCAACTTTGACTTCAAGGGTGACCCTAT
TGGTGGGCATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAAGAAGCTTTCATTCTTTCTATCAGCT
ACTCCAAGGAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACAACTATATTCATGTGGGAGCTCAATT
AAAGTCTTCTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCTTCAAACCTGAGGAGATCCAAACAGT
GTATAAGATTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGCCTCTTATTGAGAATGGCAAAGTAGT
ATCTATCATAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGACTGTGGCCACAGGCCGTGACATCAT
TGACAAGCAGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATGAGCGCCTTTTTTGTTGGATCGTTAC
TCGCATCAATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTATTGGTGTCTTGGATATCTATGGCTT
TGAAATCTTTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGCAGCTATTTATTCAGCTGGTTCTGAA
GCAAGAACAAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATCAGATCATTGTTGACCTCGTGGAGCA
ACAGCACAAAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATGAAATGTTTCTTGAAGCACTTAACAG
TAAATTGGGCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGTTTGATCGAGATTTTCGAATTCGACA
TTATGCAGGCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTCAAGATTTCAAGCGCCTTATGTATAA
CAGTTCAAATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCAAGCGACCTCTGACTGCTGCTACCTT
GTTTAAGAATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTTGCATCAAACCCAATGACAAGAAATC
TCCACAGATATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATGTGAGAGTGCGTCGGGCAGGATTTGC
CTTCCGCCAGACATACGAGAAGTTTCTTCACAGATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCCACAGC
CTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAATGTCCTCTACAAGC
CTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTTTCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAA

>56647_56647_2_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000427275_length(amino acids)=622AA_BP=
MARFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYI
AAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQ
GGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSI
IAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEI
FDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKL
GKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFK

--------------------------------------------------------------
>56647_56647_3_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000560016_length(transcript)=2672nt_BP=2193nt
TTCTTCAACTTCTTGATTTACCCTAGGCTGGGGTTCCCAAATCCAGCTTTGTGTCATGATCACCCAGCTTTTAAAATACGCAGATTCCCC
GGACTCTGTCTTCTGGAGATGGTGATTTATTAAGCCTCCTTAGTGCCCAGCTCAAATGAAGAAATATTGCACCAGAAGAAGAAAGCCAAG
AAATGAAGTCACAACGTCAGTCATTTAATCCACCACCTGTGGTCCTAACTAGTTCTTATGTCCTGTGGAACACACAGTCTAACAAGGGGA
TAAAACTAATTGACTCCATCACATGGAAACCATGATTTTTGCCAAGAGAAGCAGAAACAAGATGCTTTCACCCTTGGGAGAGATTCTCAT
CTAAGAACTGGCAAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTGTGAACCCTTACAAGTTGTTGAACAT
CTATGGAAGAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTTTTGCTATTGCGGATGCTGCTTACAA
GGCTATGAAGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAACGGAAGCCAGTAAGTACATTATGCA
GTATATTGCGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGCTTAAGTCCAACTGTGTTTTGGAAGC
TTTTGGAAATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCAACTTTGACTTCAAGGGTGACCCTAT
TGGTGGGCATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAAGAAGCTTTCATTCTTTCTATCAGCT
ACTCCAAGGAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACAACTATATTCATGTGGGAGCTCAATT
AAAGTCTTCTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCTTCAAACCTGAGGAGATCCAAACAGT
GTATAAGATTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGCCTCTTATTGAGAATGGCAAAGTAGT
ATCTATCATAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGACTGTGGCCACAGGCCGTGACATCAT
TGACAAGCAGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATGAGCGCCTTTTTTGTTGGATCGTTAC
TCGCATCAATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTATTGGTGTCTTGGATATCTATGGCTT
TGAAATCTTTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGCAGCTATTTATTCAGCTGGTTCTGAA
GCAAGAACAAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATCAGATCATTGTTGACCTCGTGGAGCA
ACAGCACAAAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATGAAATGTTTCTTGAAGCACTTAACAG
TAAATTGGGCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGTTTGATCGAGATTTTCGAATTCGACA
TTATGCAGGCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTCAAGATTTCAAGCGCCTTATGTATAA
CAGTTCAAATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCAAGCGACCTCTGACTGCTGCTACCTT
GTTTAAGAATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTTGCATCAAACCCAATGACAAGAAATC
TCCACAGATATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATGTGAGAGTGCGTCGGGCAGGATTTGC
CTTCCGCCAGACATACGAGAAGTTTCTTCACAGATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCCACAGC
CTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAAGCCTCAACACCTCC
CAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCAGCCCGTCCAGTTCTCCCAGCAGCTGCACAGCCCT
CACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTTCATGGCAGCTGTGACTCAGCTGCAGAACTCACAC
ATGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGACCCTGTTTTCCACACCATCACCCTCTGGGC

>56647_56647_3_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000560016_length(amino acids)=622AA_BP=
MARFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYI
AAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQ
GGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSI
IAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEI
FDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKL
GKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFK

--------------------------------------------------------------
>56647_56647_4_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000561193_length(transcript)=2861nt_BP=2193nt
TTCTTCAACTTCTTGATTTACCCTAGGCTGGGGTTCCCAAATCCAGCTTTGTGTCATGATCACCCAGCTTTTAAAATACGCAGATTCCCC
GGACTCTGTCTTCTGGAGATGGTGATTTATTAAGCCTCCTTAGTGCCCAGCTCAAATGAAGAAATATTGCACCAGAAGAAGAAAGCCAAG
AAATGAAGTCACAACGTCAGTCATTTAATCCACCACCTGTGGTCCTAACTAGTTCTTATGTCCTGTGGAACACACAGTCTAACAAGGGGA
TAAAACTAATTGACTCCATCACATGGAAACCATGATTTTTGCCAAGAGAAGCAGAAACAAGATGCTTTCACCCTTGGGAGAGATTCTCAT
CTAAGAACTGGCAAGATTTGAAAAAGGGCGCATCTATACGTTCATTGGAGAAGTCGTCGTTTCTGTGAACCCTTACAAGTTGTTGAACAT
CTATGGAAGAGACACAATTGAGCAGTATAAAGGCCGTGAGCTGTATGAGAGACCGCCTCACCTTTTTGCTATTGCGGATGCTGCTTACAA
GGCTATGAAGAGGCGATCAAAAGACACTTGTATTGTGATATCAGGGGAAAGTGGAGCTGGTAAAACGGAAGCCAGTAAGTACATTATGCA
GTATATTGCGGCCATCACCAACCCCAGTCAGAGAGCAGAGGTTGAAAGAGTGAAGAATATGTTGCTTAAGTCCAACTGTGTTTTGGAAGC
TTTTGGAAATGCCAAAACCAACCGTAATGACAACTCAAGCAGGTTTGGAAAATACATGGATATCAACTTTGACTTCAAGGGTGACCCTAT
TGGTGGGCATATCAATAACTACTTACTAGAAAAGTCTCGAGTGATTGTGCAACAGCCAGGAGAAAGAAGCTTTCATTCTTTCTATCAGCT
ACTCCAAGGAGGTTCAGAACAAATGCTACGCTCTCTACATCTCCAGAAATCCCTTTCATCCTACAACTATATTCATGTGGGAGCTCAATT
AAAGTCTTCTATCAATGATGCTGCCGAATTCAGAGTTGTTGCTGATGCCATGAAAGTCATTGGCTTCAAACCTGAGGAGATCCAAACAGT
GTATAAGATTTTGGCTGCTATTCTGCACTTGGGAAATTTAAAATTTGTAGTAGATGGTGACACGCCTCTTATTGAGAATGGCAAAGTAGT
ATCTATCATAGCAGAATTGCTCTCTACTAAGACAGATATGGTTGAGAAAGCCCTTCTTTACCGGACTGTGGCCACAGGCCGTGACATCAT
TGACAAGCAGCACACAGAACAAGAGGCCAGCTACGGCAGAGACGCCTTTGCCAAGGCAATATATGAGCGCCTTTTTTGTTGGATCGTTAC
TCGCATCAATGATATTATTGAGGTCAAGAACTATGACACCACAATCCATGGGAAAAACACTGTTATTGGTGTCTTGGATATCTATGGCTT
TGAAATCTTTGACAACAACAGTTTTGAACAATTCTGTATCAATTACTGCAATGAGAAACTGCAGCAGCTATTTATTCAGCTGGTTCTGAA
GCAAGAACAAGAGGAATACCAGCGGGAAGGGATCCCCTGGAAACATATTGACTACTTCAACAATCAGATCATTGTTGACCTCGTGGAGCA
ACAGCACAAAGGGATCATTGCAATCCTTGATGATGCTTGCATGAATGTCGGCAAAGTCACCGATGAAATGTTTCTTGAAGCACTTAACAG
TAAATTGGGCAAACACGCCCATTTTTCCAGCCGAAAGCTCTGTGCCTCAGACAAAATTCTGGAGTTTGATCGAGATTTTCGAATTCGACA
TTATGCAGGCGATGTAGTCTATTCTGTCATTGGTTTTATTGACAAAAATAAAGATACTTTATTTCAAGATTTCAAGCGCCTTATGTATAA
CAGTTCAAATCCTGTGCTCAAGAATATGTGGCCTGAAGGCAAACTGAGCATTACAGAGGTGACCAAGCGACCTCTGACTGCTGCTACCTT
GTTTAAGAATTCTATGATTGCTCTAGTAGACAACCTTGCATCAAAGGAACCATATTACGTTCGTTGCATCAAACCCAATGACAAGAAATC
TCCACAGATATTTGATGATGAACGCTGCCGGCACCAAGTAGAATATCTTGGACTACTGGAAAATGTGAGAGTGCGTCGGGCAGGATTTGC
CTTCCGCCAGACATACGAGAAGTTTCTTCACAGATCTCAGTCTCAGGAGGAGGTTTGCCCCCAGTCAGCACCTTGACGAATATCCACAGC
CTCTCCCACCATAATCCCCAGCAATCTCAAAACCTCATCATGACACCCCTCTCTGGAGTCATGGCAATTGCACAAAGCCTCAACACCTCC
CAAGCACAGAGTGTCCCTGTCATCAACAGTGTGGCCGGCAGCCTGGCAGCCCTGCAGCCCGTCCAGTTCTCCCAGCAGCTGCACAGCCCT
CACCAGCAGCCCCTCATGCAGCAGAGCCCAGGCAGCCACATGGCCCAGCAGCCCTTCATGGCAGCTGTGACTCAGCTGCAGAACTCACAC
ATGTACGCACACAAGCAGGAACCCCCCCAGTATTCCCACACCTCCCGGTTTCCATCTGCAATGGTGGTCACAGATACCAGCAGCATCAGT
ACACTCACCAACATGTCTTCAAGTAAACAGTGTCCTCTACAAGCCTGGTGATGCCCACACACCACTTACTTCGTGCGCAACAACAAGGAC
CCTGTTTTCCACACCATCACCCTCTGGGCAGCTGTCATGGAAAAGCCCAGTGACCTGACCGGCACCTGCGAGAGGTCCCTGCTTACCTGA

>56647_56647_4_MYO1D-HNF1B_MYO1D_chr17_31048041_ENST00000394649_HNF1B_chr17_36065056_ENST00000561193_length(amino acids)=622AA_BP=
MARFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYI
AAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQ
GGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSI
IAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEI
FDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKL
GKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYO1D-HNF1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO1D-HNF1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO1D-HNF1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource