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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MYO1E-AP4E1 (FusionGDB2 ID:56670) |
Fusion Gene Summary for MYO1E-AP4E1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYO1E-AP4E1 | Fusion gene ID: 56670 | Hgene | Tgene | Gene symbol | MYO1E | AP4E1 | Gene ID | 4643 | 23431 |
| Gene name | myosin IE | adaptor related protein complex 4 subunit epsilon 1 | |
| Synonyms | FSGS6|HuncM-IC|MYO1C | CPSQ4|SPG51|STUT1 | |
| Cytomap | 15q22.2 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional myosin-IeMYO1E variant proteinmyosin-ICunconventional myosin 1E | AP-4 complex subunit epsilon-1AP-4 adaptor complex subunit epsilonadaptor related protein complex 4 epsilon 1 subunitadaptor-related protein complex AP-4 epsilonepsilon-adaptin | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q12965 | Q9UPM8 | |
| Ensembl transtripts involved in fusion gene | ENST00000288235, ENST00000558814, | ENST00000561397, ENST00000261842, ENST00000560508, | |
| Fusion gene scores | * DoF score | 21 X 20 X 9=3780 | 2 X 2 X 2=8 |
| # samples | 29 | 2 | |
| ** MAII score | log2(29/3780*10)=-3.7042614290935 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MYO1E [Title/Abstract] AND AP4E1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MYO1E(59445788)-AP4E1(51293222), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across MYO1E (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across AP4E1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 5381N | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + |
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Fusion Gene ORF analysis for MYO1E-AP4E1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000288235 | ENST00000561397 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + |
| In-frame | ENST00000288235 | ENST00000261842 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + |
| In-frame | ENST00000288235 | ENST00000560508 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + |
| intron-3CDS | ENST00000558814 | ENST00000261842 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + |
| intron-3CDS | ENST00000558814 | ENST00000560508 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + |
| intron-3UTR | ENST00000558814 | ENST00000561397 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000288235 | MYO1E | chr15 | 59445788 | - | ENST00000261842 | AP4E1 | chr15 | 51293222 | + | 7037 | 3480 | 334 | 3798 | 1154 |
| ENST00000288235 | MYO1E | chr15 | 59445788 | - | ENST00000560508 | AP4E1 | chr15 | 51293222 | + | 7031 | 3480 | 334 | 3798 | 1154 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000288235 | ENST00000261842 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + | 0.000170354 | 0.99982965 |
| ENST00000288235 | ENST00000560508 | MYO1E | chr15 | 59445788 | - | AP4E1 | chr15 | 51293222 | + | 0.000170978 | 0.99982893 |
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Fusion Genomic Features for MYO1E-AP4E1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MYO1E-AP4E1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:59445788/chr15:51293222) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYO1E | AP4E1 |
| FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408}. | FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MYO1E | chr15:59445788 | chr15:51293222 | ENST00000288235 | - | 26 | 28 | 19_692 | 1026 | 1109.0 | Domain | Myosin motor |
| Hgene | MYO1E | chr15:59445788 | chr15:51293222 | ENST00000288235 | - | 26 | 28 | 695_724 | 1026 | 1109.0 | Domain | IQ |
| Hgene | MYO1E | chr15:59445788 | chr15:51293222 | ENST00000288235 | - | 26 | 28 | 730_922 | 1026 | 1109.0 | Domain | TH1 |
| Hgene | MYO1E | chr15:59445788 | chr15:51293222 | ENST00000288235 | - | 26 | 28 | 112_119 | 1026 | 1109.0 | Nucleotide binding | ATP |
| Hgene | MYO1E | chr15:59445788 | chr15:51293222 | ENST00000288235 | - | 26 | 28 | 581_591 | 1026 | 1109.0 | Region | Actin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MYO1E | chr15:59445788 | chr15:51293222 | ENST00000288235 | - | 26 | 28 | 1051_1108 | 1026 | 1109.0 | Domain | SH3 |
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Fusion Gene Sequence for MYO1E-AP4E1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >56670_56670_1_MYO1E-AP4E1_MYO1E_chr15_59445788_ENST00000288235_AP4E1_chr15_51293222_ENST00000261842_length(transcript)=7037nt_BP=3480nt ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGGGAAGCAAAGGTGTCTACCAGTACCACTGGCAAAGCCACAATGTCAA GCACAGTGGTGTGGACGACATGGTGCTACTGTCCAAGATCACAGAGAACTCCATCGTGGAGAATCTGAAGAAGAGATACATGGATGACTA CATTTTTACATATATAGGATCTGTATTAATCTCAGTCAACCCTTTCAAGCAGATGCCATATTTTGGGGAAAAGGAAATTGAAATGTACCA AGGAGCGGCACAGTATGAAAACCCACCACATATCTATGCCCTTGCAGATAATATGTACAGAAACATGATCATTGACAGAGAGAACCAGTG CGTCATTATCAGTGGTGAAAGTGGTGCTGGAAAAACAGTGGCTGCCAAATATATCATGAGCTACATCTCCAGAGTGTCTGGAGGAGGGAC CAAAGTCCAGCACGTGAAGGACATTATCCTGCAGTCCAACCCGCTGCTGGAGGCCTTCGGGAACGCCAAGACCGTCCGGAACAACAACTC CAGCCGATTTGGAAAATACTTTGAAATCCAGTTCAGTCCAGGTGGGGAACCAGATGGTGGAAAGATCTCCAACTTCCTTCTGGAAAAATC TAGGGTGGTGATGAGGAACCCAGGAGAGCGGAGTTTTCACATATTTTACCAGCTCATCGAGGGCGCCTCTGCAGAGCAGAAACACAGCCT TGGCATCACCAGCATGGACTATTATTACTACCTGAGCCTCTCGGGCTCATACAAGGTTGATGACATTGACGACAGGCGGGAGTTTCAGGA AACTCTGCACGCCATGAATGTGATTGGGATCTTTGCAGAAGAGCAAACGCTGGTGTTGCAGATAGTGGCGGGTATTCTCCACCTGGGAAA CATCAGCTTCAAAGAAGTTGGCAACTACGCGGCTGTGGAGAGTGAAGAGTTTTTAGCTTTTCCTGCATATCTGCTAGGGATAAACCAGGA CCGGTTGAAAGAAAAGCTAACAAGCCGGCAGATGGATAGCAAGTGGGGAGGCAAATCCGAATCCATCCACGTGACCCTCAACGTAGAGCA GGCCTGTTACACCCGGGATGCGCTCGCCAAGGCCCTGCACGCCCGGGTCTTTGATTTCTTGGTAGATTCCATCAATAAAGCCATGGAGAA AGACCATGAAGAATACAACATTGGCGTCCTAGACATCTATGGCTTTGAAATATTCCAGAAAAATGGCTTTGAACAGTTTTGTATCAATTT TGTTAATGAAAAACTGCAGCAGATTTTTATTGAACTGACATTAAAGGCAGAACAGGAAGAATATGTTCAAGAGGGAATAAGATGGACACC CATTGAGTACTTTAATAATAAAATCGTATGTGACCTCATAGAGAACAAAGTGAACCCTCCTGGCATCATGAGCATCCTGGATGACGTGTG CGCCACGATGCATGCGGTGGGTGAGGGGGCAGATCAGACGCTGCTCCAGAAACTTCAGATGCAGATTGGGAGTCATGAGCACTTCAACAG TTGGAACCAAGGCTTCATCATTCATCATTATGCTGGGAAGGTATCCTATGACATGGATGGCTTTTGTGAAAGGAACCGGGATGTGCTTTT TATGGATCTCATCGAGCTTATGCAGAGCAGCGAGCTGCCTTTCATAAAGTCTTTATTTCCGGAAAATCTGCAGGCTGACAAGAAAGGGCG CCCAACTACTGCCGGAAGCAAAATAAAGAAACAAGCCAATGACCTTGTGAGCACCCTGATGAAATGTACGCCCCACTACATTCGCTGCAT CAAGCCAAACGAAACCAAGAAGCCCAGAGACTGGGAGGAAAGCAGGGTAAAGCATCAAGTCGAATATTTGGGTCTGAAAGAGAACATTCG AGTGAGAAGAGCTGGCTATGCCTATCGGCGCATCTTCCAAAAATTCCTACAGAGGTATGCCATTCTGACCAAAGCCACCTGGCCTTCTTG GCAGGGAGAGGAGAAGCAAGGCGTCCTGCACCTGCTGCAGTCGGTCAACATGGACAGCGACCAGTTCCAGCTGGGGAGGAGTAAAGTGTT CATCAAAGCCCCCGAGTCTCTATTTCTTTTAGAAGAGATGAGAGAGAGAAAGTATGATGGGTATGCTCGAGTGATACAGAAATCATGGAG GAAATTCGTGGCCCGGAAGAAATACGTTCAAATGAGAGAAGAAGCCTCAGACCTCTTATTGAACAAGAAGGAGAGAAGGAGAAACAGTAT TAACAGGAACTTTATAGGGGATTATATTGGGATGGAAGAGCACCCAGAACTCCAGCAGTTCGTGGGCAAGAGGGAGAAGATTGATTTCGC AGACACAGTCACCAAGTATGACAGGAGGTTCAAGGGTGTAAAGCGAGACCTGCTCCTTACCCCAAAGTGCTTGTACTTAATCGGACGAGA AAAAGTCAAACAGGGCCCAGACAAGGGCCTGGTGAAAGAAGTCCTGAAGCGGAAAATCGAGATAGAACGGATCTTGTCTGTGTCCCTCAG TACTATGCAGGATGACATTTTTATTCTCCATGAGCAAGAGTATGACAGTTTGCTTGAATCTGTCTTCAAAACTGAATTCCTAAGCCTCTT AGCAAAGCGTTACGAGGAGAAGACCCAGAAGCAACTACCTCTGAAATTCAGCAATACGCTTGAACTGAAGTTGAAAAAGGAAAACTGGGG CCCCTGGAGTGCAGGGGGCTCCCGGCAAGTGCAGTTCCACCAAGGGTTTGGGGACCTGGCTGTCCTCAAGCCCAGTAACAAAGTGCTGCA GGTCAGCATCGGACCTGGACTGCCCAAGAACTCCCGTCCTACCAGAAGGAACACTACCCAAAATACAGGTTATTCCAGTGGGACTCAAAA TGCCAACTACCCAGTGAGAGCTGCCCCTCCTCCCCCAGGATACCATCAGAACGGAGTCATCAGAAACCAGTATGTGCCATATCCCCATGC TCCTGGAAGCCAGAGGTCCAATCAGAAAAGCCTGTACACCTCCATGGCCCGCCCGCCCTTGCCTCGGCAGCAGTCTACCAGTTCAGACCG AGTGTCACAGACGCCAGAGAGCCTGGATTTCCTCAAGGTCCCGGACCAGGGAGCTGCAGGACCATTAAAAATCTCAAGTGACGACTTTGG GAAACTCTGGTTATCCTTCGCAAATGATGTGAAACAAAATGTAAAAATGTCAGAATCTCAAGCTGCACTTCCTTCTGCACTAAAGACTCT GCAACAGAAACTAAGACTCCATATTATTGAGATTATAGGCAATGAAGGGCTATTGGCCTGTCAGCTGCTCCCATCCATCCCCTGCTTACT GCATTGCCGAGTTCATGCAGATGTATTAGCCCTGTGGTTCAGATCCTCCTGTTCTACTCTTCCTGACTATTTACTGTATCAGTGTCAAAA GGTGATGGAGGGATCCTAGCAGAAGCCCTGCTAAATTTTACTCCATCAAGATCAATGGTTTACATAGATAAACTTATTTACCAAAGTAAA AAGAACTCATGGTACTTCTAATGAAAATGGGGATTATTACAAGTGTGGTTTATATGTTTTCTTTGTGATTCCTGGTCAAGAAAGATCCCC AAAACTGTATCCCTAACCTTTAACTCAGGATTGTACAGTATGTTTAGGTCCCTCAAAAAGTGACCTAAGCTAATGTTATAAACTGCTAAT GATTTATATATCACTTAGTGTGTAGAGGGACTGAAAATATTTATTTTGTTATAAATAATTTTATAGCACGTTTACTCTAGTGCTAGCTAA TTTGTAATAAAGCCAAGTCTCAGTTTTCTGCATTAAATGGAAGGGAGACATGAAATTGATAATCTCAAACTTAATTCATATTTGGCTTTG GAATGTAGTGTATGGTTTTTGGTAGGGAAGTCAATATTTTCGATTATGTTTTGCTTAGATCAGTGTTGAACTAAGTTGGCATAGCACACA CTAACAGTTGTAGGAGATCCATGAGCATGCTGGATATTGAGGGGATCCAATCTGTGATCTATTTTTTATTATAGATAACTGTTACACATA ATTTCAGATCGTTTGGCTGTAAAATTTGTCTGTTTTCCACTTGGAGTTATTTTAAAATTCAAAGTAAATCACTCTATTCTTATTTTGAAA ACTCAGAGCCATTTTATATAGAAACAAAACCCATAAGAGCACACAGTAACAAAGCAAACAGATACAAAAATGACTTTTTAGTTATGACAA ATATTTTAGTTGGTTACTACTTAGGTCCTTTTGGCAAATGAAAATTTGTGATTAGAGTATAAATGGCAAAACTATCTTTTCCTGGCCTTT GAATCCACTAGTACTTAATGGATATAGCTGAAGCAGAGACTAAGTATAACATACAGGTTCTTCAGTAAAATATATCATTTTCATGTTATA GTTATGCCTGTGTGGCCTCTGTCAGAACTATTATCAGTAAAAGAGGTTAAGCCTATATATGAATGATGGACCAAAACCTTGAGGTTGTAC ATTAACTGAAATAGTATTTTATAAAATCTTATGGTGCTGTGGAAAATATTTATTATTTCACCTTTTCTGACACTTCACCATGGAGACTAT TCAGGTAATACAATTTTAAGTCATTGCAGTTAATACTCTGGTTAATTGGTACTGTTAATCACCCAGGTCAGGAATTCTGATTTTAGGTTA TCTCATTAATCATGGCTGATAAAGAAGCTAAGGGGATTCTCCAGATCTAATAGATTTCATTAGTCATTTGTGTCGAGTATTCCTCCCTAA AAACAAAAGCAGTATTTTCTTTCTCAATTAATTTTTAAGTTATTCATTAAAAAATATATAACATCTTAATTTTATTCTTTTAAAAACATA CAGTGAAGCCTTGCTACAAGAGTCATAAGTGACTGGAATTTCTTGCATAATAGGTTCCTCCTTTTGAATAGATCAGATTCATCCCCAGGC TCTCAGCAGTGTCATGATGAAATGAGTGTGCTGACTTCAGGGGTGTGGTGGACACTGGTAGCTAGCCTTATCAGCTCCCTCCTTATTCCT ACCTCTGTCAGCAGCATGCCTCGCCCCTTACCTAATTCTGCTGTGACTCTGACAGAGAGGAAGTGCCTTCTCACTTTGCAAAGGAATGCA GCATGTCACAAAGGAGGTGCTCCAATTTTTTGTGTCCTTACTTCCCTATGTTTGCCTAGTTACTGAGGCTAGGTCGAGTGTGAAGCAATA GGTGTAAGATGCTGAGAGCACATGGACAGCTACCAGGGAGATCTGTTGCTTGGTTACAGGGTGTATTCATGAGTGGTAGCTGCAGTTGTC GTGAGAGACATGCTTGGCATACAGAGCTGTCTAATGGGTGGGAGACATGTAATGGTAGATTTAGGGCTGGGAGCATGATTTTGGGTCTGC CCAAAGGAACATGGTGTCACTTTTGTTCTTTCTGACCCACTAAATAAAAAGTAGTGTAACAGGGTTTCACTGGAATGTTTATTAGAAAGT TTACACTTTTTATATTTTTATGATTTTAAAAACAAACAATAATAGAAAAACAGATTTTAAGGAACTTCAGAGCAGTATATATTCTGTCTA AACTCACTGAATATTTTAAGTTGTAAATCAGGTGTCCACCAACCTTTATTTTTGCATTGCAGGAGATGTGACTGTAAAGTAGGGAGTTTT TTTTTTTGAGACAGAGTTTCACCCTTGTTGCCCAGGCTAGAGTGTAATGGTGCAATCTCCGCTCACTGCAACCTCTGCCTCCCAGGTTCA AGCGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCATGCACCACCACACCCGGCTAATTTTTTTATATTTTTAGTAGAGA CAAGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAG GCGTGAGCCACTGCGCCCGGCCAAATTATTTTTGTGGGTAGATTCATTCTCTTTACCTAATAGTCATAATTTAGTCAGTGAAGGGACAAC ATCTGGGGTAAGAGCTATGGAGGAGGTGCTCAGCTTTGTGAGTTTTGTGCCAGGCATCTTTGCTGAAAATGGAGATGGCAGCAAGTGTGA ATCTGGGGGAATATAAGGGAAGACAGAAAAGCCTTAAGAGTAGACGGAGGAAGAAGGGTACCAGAATAGTCCCTGTGGAGGCAGGCAGAT CAGAGCTCAGGGTTTGAAAGTGGGCCTGAGTAAGGGTCCTGCTAGAGAAACTGCAGATGGAAGCTGAGCAGTTACCAACTGCTAATGTGC CAAGTATACCAAGCACAGCATGTGTCCTGTAGAGGAGCATTATTTTAAACAATGTTCTACTATCATCTACCAAAATAATTGTGGTAAAAG TGTAGTATTTTATTTTTTCCTTTTATGTCAGCAATATTTTAAAATATTGATCTGTTTATCTTATATTTTTATGGATAAATGTAGTATTTG CCTCATGATTGTGAGCCACTGAGAGTGCACTGAACCTATTCACATGTCTTTAAGATGTTTTGCTGTGTTAAAATTTTAGGAGAGAAAAAT ACAAGTGAATAATTATTTAATAGGCATTTATTACTTTATTTTGGAGTTGAATTCTGTCATTTGAAAAAGTTCAGTAATGTAATAAATACA >56670_56670_1_MYO1E-AP4E1_MYO1E_chr15_59445788_ENST00000288235_AP4E1_chr15_51293222_ENST00000261842_length(amino acids)=1154AA_BP=1049 MRSSPSSPAAGPGEDATAARVTMGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYF GEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGN AKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDD IDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSES IHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEY VQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGF CERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVE YLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGY ARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTP KCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLE LKLKKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIR NQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGPLKISSDDFGKLWLSFANDVKQNVKMSESQA -------------------------------------------------------------- >56670_56670_2_MYO1E-AP4E1_MYO1E_chr15_59445788_ENST00000288235_AP4E1_chr15_51293222_ENST00000560508_length(transcript)=7031nt_BP=3480nt ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGGGAAGCAAAGGTGTCTACCAGTACCACTGGCAAAGCCACAATGTCAA GCACAGTGGTGTGGACGACATGGTGCTACTGTCCAAGATCACAGAGAACTCCATCGTGGAGAATCTGAAGAAGAGATACATGGATGACTA CATTTTTACATATATAGGATCTGTATTAATCTCAGTCAACCCTTTCAAGCAGATGCCATATTTTGGGGAAAAGGAAATTGAAATGTACCA AGGAGCGGCACAGTATGAAAACCCACCACATATCTATGCCCTTGCAGATAATATGTACAGAAACATGATCATTGACAGAGAGAACCAGTG CGTCATTATCAGTGGTGAAAGTGGTGCTGGAAAAACAGTGGCTGCCAAATATATCATGAGCTACATCTCCAGAGTGTCTGGAGGAGGGAC CAAAGTCCAGCACGTGAAGGACATTATCCTGCAGTCCAACCCGCTGCTGGAGGCCTTCGGGAACGCCAAGACCGTCCGGAACAACAACTC CAGCCGATTTGGAAAATACTTTGAAATCCAGTTCAGTCCAGGTGGGGAACCAGATGGTGGAAAGATCTCCAACTTCCTTCTGGAAAAATC TAGGGTGGTGATGAGGAACCCAGGAGAGCGGAGTTTTCACATATTTTACCAGCTCATCGAGGGCGCCTCTGCAGAGCAGAAACACAGCCT TGGCATCACCAGCATGGACTATTATTACTACCTGAGCCTCTCGGGCTCATACAAGGTTGATGACATTGACGACAGGCGGGAGTTTCAGGA AACTCTGCACGCCATGAATGTGATTGGGATCTTTGCAGAAGAGCAAACGCTGGTGTTGCAGATAGTGGCGGGTATTCTCCACCTGGGAAA CATCAGCTTCAAAGAAGTTGGCAACTACGCGGCTGTGGAGAGTGAAGAGTTTTTAGCTTTTCCTGCATATCTGCTAGGGATAAACCAGGA CCGGTTGAAAGAAAAGCTAACAAGCCGGCAGATGGATAGCAAGTGGGGAGGCAAATCCGAATCCATCCACGTGACCCTCAACGTAGAGCA GGCCTGTTACACCCGGGATGCGCTCGCCAAGGCCCTGCACGCCCGGGTCTTTGATTTCTTGGTAGATTCCATCAATAAAGCCATGGAGAA AGACCATGAAGAATACAACATTGGCGTCCTAGACATCTATGGCTTTGAAATATTCCAGAAAAATGGCTTTGAACAGTTTTGTATCAATTT TGTTAATGAAAAACTGCAGCAGATTTTTATTGAACTGACATTAAAGGCAGAACAGGAAGAATATGTTCAAGAGGGAATAAGATGGACACC CATTGAGTACTTTAATAATAAAATCGTATGTGACCTCATAGAGAACAAAGTGAACCCTCCTGGCATCATGAGCATCCTGGATGACGTGTG CGCCACGATGCATGCGGTGGGTGAGGGGGCAGATCAGACGCTGCTCCAGAAACTTCAGATGCAGATTGGGAGTCATGAGCACTTCAACAG TTGGAACCAAGGCTTCATCATTCATCATTATGCTGGGAAGGTATCCTATGACATGGATGGCTTTTGTGAAAGGAACCGGGATGTGCTTTT TATGGATCTCATCGAGCTTATGCAGAGCAGCGAGCTGCCTTTCATAAAGTCTTTATTTCCGGAAAATCTGCAGGCTGACAAGAAAGGGCG CCCAACTACTGCCGGAAGCAAAATAAAGAAACAAGCCAATGACCTTGTGAGCACCCTGATGAAATGTACGCCCCACTACATTCGCTGCAT CAAGCCAAACGAAACCAAGAAGCCCAGAGACTGGGAGGAAAGCAGGGTAAAGCATCAAGTCGAATATTTGGGTCTGAAAGAGAACATTCG AGTGAGAAGAGCTGGCTATGCCTATCGGCGCATCTTCCAAAAATTCCTACAGAGGTATGCCATTCTGACCAAAGCCACCTGGCCTTCTTG GCAGGGAGAGGAGAAGCAAGGCGTCCTGCACCTGCTGCAGTCGGTCAACATGGACAGCGACCAGTTCCAGCTGGGGAGGAGTAAAGTGTT CATCAAAGCCCCCGAGTCTCTATTTCTTTTAGAAGAGATGAGAGAGAGAAAGTATGATGGGTATGCTCGAGTGATACAGAAATCATGGAG GAAATTCGTGGCCCGGAAGAAATACGTTCAAATGAGAGAAGAAGCCTCAGACCTCTTATTGAACAAGAAGGAGAGAAGGAGAAACAGTAT TAACAGGAACTTTATAGGGGATTATATTGGGATGGAAGAGCACCCAGAACTCCAGCAGTTCGTGGGCAAGAGGGAGAAGATTGATTTCGC AGACACAGTCACCAAGTATGACAGGAGGTTCAAGGGTGTAAAGCGAGACCTGCTCCTTACCCCAAAGTGCTTGTACTTAATCGGACGAGA AAAAGTCAAACAGGGCCCAGACAAGGGCCTGGTGAAAGAAGTCCTGAAGCGGAAAATCGAGATAGAACGGATCTTGTCTGTGTCCCTCAG TACTATGCAGGATGACATTTTTATTCTCCATGAGCAAGAGTATGACAGTTTGCTTGAATCTGTCTTCAAAACTGAATTCCTAAGCCTCTT AGCAAAGCGTTACGAGGAGAAGACCCAGAAGCAACTACCTCTGAAATTCAGCAATACGCTTGAACTGAAGTTGAAAAAGGAAAACTGGGG CCCCTGGAGTGCAGGGGGCTCCCGGCAAGTGCAGTTCCACCAAGGGTTTGGGGACCTGGCTGTCCTCAAGCCCAGTAACAAAGTGCTGCA GGTCAGCATCGGACCTGGACTGCCCAAGAACTCCCGTCCTACCAGAAGGAACACTACCCAAAATACAGGTTATTCCAGTGGGACTCAAAA TGCCAACTACCCAGTGAGAGCTGCCCCTCCTCCCCCAGGATACCATCAGAACGGAGTCATCAGAAACCAGTATGTGCCATATCCCCATGC TCCTGGAAGCCAGAGGTCCAATCAGAAAAGCCTGTACACCTCCATGGCCCGCCCGCCCTTGCCTCGGCAGCAGTCTACCAGTTCAGACCG AGTGTCACAGACGCCAGAGAGCCTGGATTTCCTCAAGGTCCCGGACCAGGGAGCTGCAGGACCATTAAAAATCTCAAGTGACGACTTTGG GAAACTCTGGTTATCCTTCGCAAATGATGTGAAACAAAATGTAAAAATGTCAGAATCTCAAGCTGCACTTCCTTCTGCACTAAAGACTCT GCAACAGAAACTAAGACTCCATATTATTGAGATTATAGGCAATGAAGGGCTATTGGCCTGTCAGCTGCTCCCATCCATCCCCTGCTTACT GCATTGCCGAGTTCATGCAGATGTATTAGCCCTGTGGTTCAGATCCTCCTGTTCTACTCTTCCTGACTATTTACTGTATCAGTGTCAAAA GGTGATGGAGGGATCCTAGCAGAAGCCCTGCTAAATTTTACTCCATCAAGATCAATGGTTTACATAGATAAACTTATTTACCAAAGTAAA AAGAACTCATGGTACTTCTAATGAAAATGGGGATTATTACAAGTGTGGTTTATATGTTTTCTTTGTGATTCCTGGTCAAGAAAGATCCCC AAAACTGTATCCCTAACCTTTAACTCAGGATTGTACAGTATGTTTAGGTCCCTCAAAAAGTGACCTAAGCTAATGTTATAAACTGCTAAT GATTTATATATCACTTAGTGTGTAGAGGGACTGAAAATATTTATTTTGTTATAAATAATTTTATAGCACGTTTACTCTAGTGCTAGCTAA TTTGTAATAAAGCCAAGTCTCAGTTTTCTGCATTAAATGGAAGGGAGACATGAAATTGATAATCTCAAACTTAATTCATATTTGGCTTTG GAATGTAGTGTATGGTTTTTGGTAGGGAAGTCAATATTTTCGATTATGTTTTGCTTAGATCAGTGTTGAACTAAGTTGGCATAGCACACA CTAACAGTTGTAGGAGATCCATGAGCATGCTGGATATTGAGGGGATCCAATCTGTGATCTATTTTTTATTATAGATAACTGTTACACATA ATTTCAGATCGTTTGGCTGTAAAATTTGTCTGTTTTCCACTTGGAGTTATTTTAAAATTCAAAGTAAATCACTCTATTCTTATTTTGAAA ACTCAGAGCCATTTTATATAGAAACAAAACCCATAAGAGCACACAGTAACAAAGCAAACAGATACAAAAATGACTTTTTAGTTATGACAA ATATTTTAGTTGGTTACTACTTAGGTCCTTTTGGCAAATGAAAATTTGTGATTAGAGTATAAATGGCAAAACTATCTTTTCCTGGCCTTT GAATCCACTAGTACTTAATGGATATAGCTGAAGCAGAGACTAAGTATAACATACAGGTTCTTCAGTAAAATATATCATTTTCATGTTATA GTTATGCCTGTGTGGCCTCTGTCAGAACTATTATCAGTAAAAGAGGTTAAGCCTATATATGAATGATGGACCAAAACCTTGAGGTTGTAC ATTAACTGAAATAGTATTTTATAAAATCTTATGGTGCTGTGGAAAATATTTATTATTTCACCTTTTCTGACACTTCACCATGGAGACTAT TCAGGTAATACAATTTTAAGTCATTGCAGTTAATACTCTGGTTAATTGGTACTGTTAATCACCCAGGTCAGGAATTCTGATTTTAGGTTA TCTCATTAATCATGGCTGATAAAGAAGCTAAGGGGATTCTCCAGATCTAATAGATTTCATTAGTCATTTGTGTCGAGTATTCCTCCCTAA AAACAAAAGCAGTATTTTCTTTCTCAATTAATTTTTAAGTTATTCATTAAAAAATATATAACATCTTAATTTTATTCTTTTAAAAACATA CAGTGAAGCCTTGCTACAAGAGTCATAAGTGACTGGAATTTCTTGCATAATAGGTTCCTCCTTTTGAATAGATCAGATTCATCCCCAGGC TCTCAGCAGTGTCATGATGAAATGAGTGTGCTGACTTCAGGGGTGTGGTGGACACTGGTAGCTAGCCTTATCAGCTCCCTCCTTATTCCT ACCTCTGTCAGCAGCATGCCTCGCCCCTTACCTAATTCTGCTGTGACTCTGACAGAGAGGAAGTGCCTTCTCACTTTGCAAAGGAATGCA GCATGTCACAAAGGAGGTGCTCCAATTTTTTGTGTCCTTACTTCCCTATGTTTGCCTAGTTACTGAGGCTAGGTCGAGTGTGAAGCAATA GGTGTAAGATGCTGAGAGCACATGGACAGCTACCAGGGAGATCTGTTGCTTGGTTACAGGGTGTATTCATGAGTGGTAGCTGCAGTTGTC GTGAGAGACATGCTTGGCATACAGAGCTGTCTAATGGGTGGGAGACATGTAATGGTAGATTTAGGGCTGGGAGCATGATTTTGGGTCTGC CCAAAGGAACATGGTGTCACTTTTGTTCTTTCTGACCCACTAAATAAAAAGTAGTGTAACAGGGTTTCACTGGAATGTTTATTAGAAAGT TTACACTTTTTATATTTTTATGATTTTAAAAACAAACAATAATAGAAAAACAGATTTTAAGGAACTTCAGAGCAGTATATATTCTGTCTA AACTCACTGAATATTTTAAGTTGTAAATCAGGTGTCCACCAACCTTTATTTTTGCATTGCAGGAGATGTGACTGTAAAGTAGGGAGTTTT TTTTTTTGAGACAGAGTTTCACCCTTGTTGCCCAGGCTAGAGTGTAATGGTGCAATCTCCGCTCACTGCAACCTCTGCCTCCCAGGTTCA AGCGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCATGCACCACCACACCCGGCTAATTTTTTTATATTTTTAGTAGAGA CAAGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAG GCGTGAGCCACTGCGCCCGGCCAAATTATTTTTGTGGGTAGATTCATTCTCTTTACCTAATAGTCATAATTTAGTCAGTGAAGGGACAAC ATCTGGGGTAAGAGCTATGGAGGAGGTGCTCAGCTTTGTGAGTTTTGTGCCAGGCATCTTTGCTGAAAATGGAGATGGCAGCAAGTGTGA ATCTGGGGGAATATAAGGGAAGACAGAAAAGCCTTAAGAGTAGACGGAGGAAGAAGGGTACCAGAATAGTCCCTGTGGAGGCAGGCAGAT CAGAGCTCAGGGTTTGAAAGTGGGCCTGAGTAAGGGTCCTGCTAGAGAAACTGCAGATGGAAGCTGAGCAGTTACCAACTGCTAATGTGC CAAGTATACCAAGCACAGCATGTGTCCTGTAGAGGAGCATTATTTTAAACAATGTTCTACTATCATCTACCAAAATAATTGTGGTAAAAG TGTAGTATTTTATTTTTTCCTTTTATGTCAGCAATATTTTAAAATATTGATCTGTTTATCTTATATTTTTATGGATAAATGTAGTATTTG CCTCATGATTGTGAGCCACTGAGAGTGCACTGAACCTATTCACATGTCTTTAAGATGTTTTGCTGTGTTAAAATTTTAGGAGAGAAAAAT ACAAGTGAATAATTATTTAATAGGCATTTATTACTTTATTTTGGAGTTGAATTCTGTCATTTGAAAAAGTTCAGTAATGTAATAAATACA >56670_56670_2_MYO1E-AP4E1_MYO1E_chr15_59445788_ENST00000288235_AP4E1_chr15_51293222_ENST00000560508_length(amino acids)=1154AA_BP=1049 MRSSPSSPAAGPGEDATAARVTMGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYF GEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGN AKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDD IDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSES IHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEY VQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGF CERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVE YLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGY ARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTP KCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLE LKLKKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIR NQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGPLKISSDDFGKLWLSFANDVKQNVKMSESQA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MYO1E-AP4E1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | AP4E1 | chr15:59445788 | chr15:51293222 | ENST00000261842 | 18 | 21 | 727_1137 | 1031.6666666666667 | 1138.0 | TEPSIN | |
| Tgene | AP4E1 | chr15:59445788 | chr15:51293222 | ENST00000560508 | 18 | 21 | 727_1137 | 956.6666666666666 | 1063.0 | TEPSIN |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MYO1E-AP4E1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MYO1E-AP4E1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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