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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO1E-RGS3 (FusionGDB2 ID:56681)

Fusion Gene Summary for MYO1E-RGS3

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1E-RGS3
Fusion gene ID: 56681
HgeneTgene
Gene symbol

MYO1E

RGS3

Gene ID

4643

5998

Gene namemyosin IEregulator of G protein signaling 3
SynonymsFSGS6|HuncM-IC|MYO1CC2PA|RGP3
Cytomap

15q22.2

9q32

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IeMYO1E variant proteinmyosin-ICunconventional myosin 1Eregulator of G-protein signaling 3regulator of G-protein signalling 3
Modification date2020031320200320
UniProtAcc

Q12965

.
Ensembl transtripts involved in fusion geneENST00000288235, ENST00000558814, 
ENST00000462143, ENST00000342620, 
ENST00000374134, ENST00000462403, 
ENST00000463806, ENST00000317613, 
ENST00000343817, ENST00000350696, 
ENST00000374136, ENST00000374140, 
ENST00000394646, 
Fusion gene scores* DoF score21 X 20 X 9=37804 X 3 X 4=48
# samples 294
** MAII scorelog2(29/3780*10)=-3.7042614290935
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO1E [Title/Abstract] AND RGS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO1E(59664697)-RGS3(116299076), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYO1E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RGS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AMYO1Echr15

59664697

-RGS3chr9

116299076

+


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Fusion Gene ORF analysis for MYO1E-RGS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000288235ENST00000462143MYO1Echr15

59664697

-RGS3chr9

116299076

+
5CDS-intronENST00000288235ENST00000342620MYO1Echr15

59664697

-RGS3chr9

116299076

+
5CDS-intronENST00000288235ENST00000374134MYO1Echr15

59664697

-RGS3chr9

116299076

+
5CDS-intronENST00000288235ENST00000462403MYO1Echr15

59664697

-RGS3chr9

116299076

+
5CDS-intronENST00000288235ENST00000463806MYO1Echr15

59664697

-RGS3chr9

116299076

+
In-frameENST00000288235ENST00000317613MYO1Echr15

59664697

-RGS3chr9

116299076

+
In-frameENST00000288235ENST00000343817MYO1Echr15

59664697

-RGS3chr9

116299076

+
In-frameENST00000288235ENST00000350696MYO1Echr15

59664697

-RGS3chr9

116299076

+
In-frameENST00000288235ENST00000374136MYO1Echr15

59664697

-RGS3chr9

116299076

+
In-frameENST00000288235ENST00000374140MYO1Echr15

59664697

-RGS3chr9

116299076

+
In-frameENST00000288235ENST00000394646MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-3CDSENST00000558814ENST00000317613MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-3CDSENST00000558814ENST00000343817MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-3CDSENST00000558814ENST00000350696MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-3CDSENST00000558814ENST00000374136MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-3CDSENST00000558814ENST00000374140MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-3CDSENST00000558814ENST00000394646MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-5UTRENST00000558814ENST00000462143MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-intronENST00000558814ENST00000342620MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-intronENST00000558814ENST00000374134MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-intronENST00000558814ENST00000462403MYO1Echr15

59664697

-RGS3chr9

116299076

+
intron-intronENST00000558814ENST00000463806MYO1Echr15

59664697

-RGS3chr9

116299076

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000288235MYO1Echr1559664697-ENST00000374140RGS3chr9116299076+28714033342085583
ENST00000288235MYO1Echr1559664697-ENST00000350696RGS3chr9116299076+28704033342085583
ENST00000288235MYO1Echr1559664697-ENST00000317613RGS3chr9116299076+1296403686207159
ENST00000288235MYO1Echr1559664697-ENST00000343817RGS3chr9116299076+28714033342085583
ENST00000288235MYO1Echr1559664697-ENST00000394646RGS3chr9116299076+18854033341107257
ENST00000288235MYO1Echr1559664697-ENST00000374136RGS3chr9116299076+1298403686207159

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288235ENST00000374140MYO1Echr1559664697-RGS3chr9116299076+0.0184196890.9815803
ENST00000288235ENST00000350696MYO1Echr1559664697-RGS3chr9116299076+0.0183681940.98163176
ENST00000288235ENST00000317613MYO1Echr1559664697-RGS3chr9116299076+0.559759560.44024044
ENST00000288235ENST00000343817MYO1Echr1559664697-RGS3chr9116299076+0.0184196890.9815803
ENST00000288235ENST00000394646MYO1Echr1559664697-RGS3chr9116299076+0.0101037310.9898963
ENST00000288235ENST00000374136MYO1Echr1559664697-RGS3chr9116299076+0.558163640.44183636

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Fusion Genomic Features for MYO1E-RGS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYO1E-RGS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:59664697/chr9:116299076)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO1E

Q12965

.
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRGS3chr15:59664697chr9:116299076ENST000003176131518705_819526603.0Compositional biasNote=Pro-rich
TgeneRGS3chr15:59664697chr9:116299076ENST00000343817816705_819357918.0Compositional biasNote=Pro-rich
TgeneRGS3chr15:59664697chr9:116299076ENST000003506961725705_8196381199.0Compositional biasNote=Pro-rich
TgeneRGS3chr15:59664697chr9:116299076ENST0000037413408705_8190520.0Compositional biasNote=Pro-rich
TgeneRGS3chr15:59664697chr9:116299076ENST000003741401826705_8196381199.0Compositional biasNote=Pro-rich
TgeneRGS3chr15:59664697chr9:116299076ENST0000046214307705_8190520.0Compositional biasNote=Pro-rich
TgeneRGS3chr15:59664697chr9:116299076ENST0000046240305705_8190312.0Compositional biasNote=Pro-rich
TgeneRGS3chr15:59664697chr9:116299076ENST0000031761315181073_1198526603.0DomainRGS
TgeneRGS3chr15:59664697chr9:116299076ENST000003438178161073_1198357918.0DomainRGS
TgeneRGS3chr15:59664697chr9:116299076ENST0000035069617251073_11986381199.0DomainRGS
TgeneRGS3chr15:59664697chr9:116299076ENST00000374134081073_11980520.0DomainRGS
TgeneRGS3chr15:59664697chr9:116299076ENST0000037413408137_2560520.0DomainC2
TgeneRGS3chr15:59664697chr9:116299076ENST0000037413408299_3760520.0DomainPDZ
TgeneRGS3chr15:59664697chr9:116299076ENST0000037414018261073_11986381199.0DomainRGS
TgeneRGS3chr15:59664697chr9:116299076ENST00000462143071073_11980520.0DomainRGS
TgeneRGS3chr15:59664697chr9:116299076ENST0000046214307137_2560520.0DomainC2
TgeneRGS3chr15:59664697chr9:116299076ENST0000046214307299_3760520.0DomainPDZ
TgeneRGS3chr15:59664697chr9:116299076ENST00000462403051073_11980312.0DomainRGS
TgeneRGS3chr15:59664697chr9:116299076ENST0000046240305137_2560312.0DomainC2
TgeneRGS3chr15:59664697chr9:116299076ENST0000046240305299_3760312.0DomainPDZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Echr15:59664697chr9:116299076ENST00000288235-1281051_110811109.0DomainSH3
HgeneMYO1Echr15:59664697chr9:116299076ENST00000288235-12819_69211109.0DomainMyosin motor
HgeneMYO1Echr15:59664697chr9:116299076ENST00000288235-128695_72411109.0DomainIQ
HgeneMYO1Echr15:59664697chr9:116299076ENST00000288235-128730_92211109.0DomainTH1
HgeneMYO1Echr15:59664697chr9:116299076ENST00000288235-128112_11911109.0Nucleotide bindingATP
HgeneMYO1Echr15:59664697chr9:116299076ENST00000288235-128581_59111109.0RegionActin-binding
TgeneRGS3chr15:59664697chr9:116299076ENST000003176131518137_256526603.0DomainC2
TgeneRGS3chr15:59664697chr9:116299076ENST000003176131518299_376526603.0DomainPDZ
TgeneRGS3chr15:59664697chr9:116299076ENST00000343817816137_256357918.0DomainC2
TgeneRGS3chr15:59664697chr9:116299076ENST00000343817816299_376357918.0DomainPDZ
TgeneRGS3chr15:59664697chr9:116299076ENST000003506961725137_2566381199.0DomainC2
TgeneRGS3chr15:59664697chr9:116299076ENST000003506961725299_3766381199.0DomainPDZ
TgeneRGS3chr15:59664697chr9:116299076ENST000003741401826137_2566381199.0DomainC2
TgeneRGS3chr15:59664697chr9:116299076ENST000003741401826299_3766381199.0DomainPDZ


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Fusion Gene Sequence for MYO1E-RGS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56681_56681_1_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000317613_length(transcript)=1296nt_BP=403nt
ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC
GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC
GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA
GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC
AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGAAGGCAGAGTGCTTATTCACTTTGGAAGCGCACTCGCAGGAGCAGAA
GAAGAGAGTGTGCTGGTGCCTGTCGGAGAACATCGCCAAGCAGCAACAGCTGGCAGCATCACCCCCGGACAGCAAGAAACTCCACCCTTT
CGGCTCTCTCCAGCAGGAGATGGGGCCGGTCAACTCAACCAATGCCACCCAGGATAGAAGCTTTACCTCACCAGGACAGACTCTGATTGG
CTGAGCAAACCCAAGGGCGGGACTCTGCTTCTGGCAACTTAACCCTTTCTTGGGCATCCCCTACCACACAGTAACCTCACCTCAACTGGA
CCTGAAACAGAGGACCAAGATGGTGGGTCTAGGGTCATCTGAAGGGAGTGGTCCCAAGGGTGCATGTGGATGTCAACAGAAGGACCACAA
TGGTGTGAGAGGCCTTGTGGGCATGCAGAGACTGGCAGCAGAAAGTCCCAAGAGGAGAGGACTCAGAGGCTTCTTCCTTCCAAGGAGGAG
GAGGAGGAGGACATTCCACATCTGGGCTTCCAGTGGTGGCTCCCGGACCTGCCTTGGGGGCAGCAGGAGAGGTTGGGAGAGGTCACCCTG
ATGAAGAACAATGCCATGATCTGCTGCTGCCAGAGGACATCTCCGCCCATCCACTCATTTTCCACCTGTACACATTGGCTCATTCATTCG
ATGGATATTTCGGGTGCATCTACTTTATGCCAGGCTCTATGCTAGGAGCTGGGGATACTGTGGAGAAAAAGTCGGATATGGTCTCGCTCT
CATCAAGATTTCAGTCTAGCTGGGAGTGAGCGTTAAATAAGTCAATACCAACACACACACGTGCACACACGTGATGGCAAGCTGTGATCA

>56681_56681_1_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000317613_length(amino acids)=159AA_BP=0
MPKKGLSCQKQSPALGFAQPIRVCPGEVKLLSWVALVELTGPISCWREPKGWSFLLSGGDAASCCCLAMFSDRHQHTLFFCSCECASKVN

--------------------------------------------------------------
>56681_56681_2_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000343817_length(transcript)=2871nt_BP=403nt
ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC
GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC
GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA
GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC
AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGAAGGCAGAGTGCTTATTCACTTTGGAAGCGCACTCGCAGGAGCAGAA
GAAGAGAGTGTGCTGGTGCCTGTCGGAGAACATCGCCAAGCAGCAACAGCTGGCAGCATCACCCCCGGACAGCAAGATGTTTGAGACGGA
GGCAGATGAGAAGAGGGAGATGGCCTTGGAGGAAGGGAAGGGGCCTGGTGCCGAGGATTCCCCACCCAGCAAGGAGCCCTCTCCTGGCCA
GGAGCTTCCTCCAGGACAAGACCTTCCACCCAACAAGGACTCCCCTTCTGGGCAGGAACCCGCTCCCAGCCAAGAACCACTGTCCAGCAA
AGACTCAGCTACCTCTGAAGGATCCCCTCCAGGCCCAGATGCTCCGCCCAGCAAGGATGTGCCACCATGCCAGGAACCCCCTCCAGCCCA
AGACCTCTCACCCTGCCAGGACCTACCTGCTGGTCAAGAACCCCTGCCTCACCAGGACCCTCTACTCACCAAAGACCTCCCTGCCATCCA
GGAATCCCCCACCCGGGACCTTCCACCCTGTCAAGATCTGCCTCCTAGCCAGGTCTCCCTGCCAGCCAAGGCCCTTACTGAGGACACCAT
GAGCTCCGGGGACCTACTAGCAGCTACTGGGGACCCACCTGCGGCCCCCAGGCCAGCCTTCGTGATCCCTGAGGTCCGGCTGGATAGCAC
CTACAGCCAGAAGGCAGGGGCAGAGCAGGGCTGCTCGGGAGATGAGGAGGATGCAGAAGAGGCCGAGGAGGTGGAGGAGGGGGAGGAAGG
GGAGGAGGACGAGGATGAGGACACCAGCGATGACAACTACGGAGAGCGCAGTGAGGCCAAGCGCAGCAGCATGATCGAGACGGGCCAGGG
GGCTGAGGGTGGCCTCTCACTGCGTGTGCAGAACTCGCTGCGGCGCCGGACGCACAGCGAGGGCAGCCTGCTGCAGGAGCCCCGAGGGCC
CTGCTTTGCCTCCGACACCACCTTGCACTGCTCAGACGGTGAGGGCGCCGCCTCCACCTGGGGCATGCCTTCGCCCAGCACCCTCAAGAA
AGAGCTGGGCCGCAATGGTGGCTCCATGCACCACCTTTCCCTCTTCTTCACAGGACACAGGAAGATGAGCGGGGCTGACACCGTTGGGGA
TGATGACGAAGCCTCCCGGAAGAGAAAGAGCAAAAACCTAGCCAAGGACATGAAGAACAAGCTGGGGATCTTCAGACGGCGGAATGAGTC
CCCTGGAGCCCCTCCCGCGGGCAAGGCAGACAAAATGATGAAGTCATTCAAGCCCACCTCAGAGGAAGCCCTCAAGTGGGGCGAGTCCTT
GGAGAAGCTGCTGGTTCACAAATACGGGTTAGCAGTGTTCCAAGCCTTCCTTCGCACTGAGTTCAGTGAGGAGAATCTGGAGTTCTGGTT
GGCTTGTGAGGACTTCAAGAAGGTCAAGTCACAGTCCAAGATGGCATCCAAGGCCAAGAAGATCTTTGCTGAATACATCGCGATCCAGGC
ATGCAAGGAGGTCAACCTGGACTCCTACACGCGGGAGCACACCAAGGACAACCTGCAGAGCGTCACGCGGGGCTGCTTCGACCTGGCACA
GAAGCGCATCTTCGGGCTCATGGAAAAGGACTCGTACCCTCGCTTTCTCCGTTCTGACCTCTACCTGGACCTTATTAACCAGAAGAAGAT
GAGTCCCCCGCTTTAGGGGCCACTGGAGTCGAGCTCAGCGTTCACACCAGGCGGGCTGGGTCCCCTGCCCACCTGCCTCCCTGCCCCCTG
TGACGGAGGGGGCAAGCAAGCCCCCAGAGGCTGTGTCTCTGGACAGACGGATAGACATACGGAAGCGAGGCCTGGACCAAGAGAGGCCCA
GGCTACTGGAGGAGTAGAAGGATGGGCCCCGTGGGGTCCCCACTGCCCCGGTACGAGGGGGCCCAAGACCCTGGCAGGTCAGGGGCCCTG
GCCAAGCCAGATCTGGAGCTGCTGCTCCCTGCTGCGGAGACCGCGGAGGCTTCGCGTTGACCAAGTTCCTTAAAGAACTGGCTGATGGGG
CAGGAGGTCCAGGCCTGGGCTCTCGGGCCCTCCTAGAGGGCCATTGGAGCTTGCAGCTCAGACCCCCACTTTGAGTTTTATTTATTTAAA
TAGTAGTTGGATGCTTGGCACGTCGTCCTGTAATAGGAAACCCTTGCCTCATCAGTTTTCCTGATTTACAAGTGCAATATTTTAGCCAAT
GCCTTGGGAGAAGCTGCCATGCAAAGGTGGACACCATTCTCCAGCTTCAGGGGATATGCTCGTCCCGGGCACCGGTGGCAGGCAGCTGGC
CTTCTGGACTAAGGCAGCCTGGGGGGACACTGCAGTCTGGCTACACACAGAGATCTGGCACCCCCTGGGTGGAGTGTCCCTCGGGGGCTT

>56681_56681_2_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000343817_length(amino acids)=583AA_BP=23
MRSSPSSPAAGPGEDATAARVTMKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSP
PSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPL
LTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEA
EEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWG
MPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSE
EALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSV

--------------------------------------------------------------
>56681_56681_3_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000350696_length(transcript)=2870nt_BP=403nt
ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC
GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC
GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA
GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC
AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGAAGGCAGAGTGCTTATTCACTTTGGAAGCGCACTCGCAGGAGCAGAA
GAAGAGAGTGTGCTGGTGCCTGTCGGAGAACATCGCCAAGCAGCAACAGCTGGCAGCATCACCCCCGGACAGCAAGATGTTTGAGACGGA
GGCAGATGAGAAGAGGGAGATGGCCTTGGAGGAAGGGAAGGGGCCTGGTGCCGAGGATTCCCCACCCAGCAAGGAGCCCTCTCCTGGCCA
GGAGCTTCCTCCAGGACAAGACCTTCCACCCAACAAGGACTCCCCTTCTGGGCAGGAACCCGCTCCCAGCCAAGAACCACTGTCCAGCAA
AGACTCAGCTACCTCTGAAGGATCCCCTCCAGGCCCAGATGCTCCGCCCAGCAAGGATGTGCCACCATGCCAGGAACCCCCTCCAGCCCA
AGACCTCTCACCCTGCCAGGACCTACCTGCTGGTCAAGAACCCCTGCCTCACCAGGACCCTCTACTCACCAAAGACCTCCCTGCCATCCA
GGAATCCCCCACCCGGGACCTTCCACCCTGTCAAGATCTGCCTCCTAGCCAGGTCTCCCTGCCAGCCAAGGCCCTTACTGAGGACACCAT
GAGCTCCGGGGACCTACTAGCAGCTACTGGGGACCCACCTGCGGCCCCCAGGCCAGCCTTCGTGATCCCTGAGGTCCGGCTGGATAGCAC
CTACAGCCAGAAGGCAGGGGCAGAGCAGGGCTGCTCGGGAGATGAGGAGGATGCAGAAGAGGCCGAGGAGGTGGAGGAGGGGGAGGAAGG
GGAGGAGGACGAGGATGAGGACACCAGCGATGACAACTACGGAGAGCGCAGTGAGGCCAAGCGCAGCAGCATGATCGAGACGGGCCAGGG
GGCTGAGGGTGGCCTCTCACTGCGTGTGCAGAACTCGCTGCGGCGCCGGACGCACAGCGAGGGCAGCCTGCTGCAGGAGCCCCGAGGGCC
CTGCTTTGCCTCCGACACCACCTTGCACTGCTCAGACGGTGAGGGCGCCGCCTCCACCTGGGGCATGCCTTCGCCCAGCACCCTCAAGAA
AGAGCTGGGCCGCAATGGTGGCTCCATGCACCACCTTTCCCTCTTCTTCACAGGACACAGGAAGATGAGCGGGGCTGACACCGTTGGGGA
TGATGACGAAGCCTCCCGGAAGAGAAAGAGCAAAAACCTAGCCAAGGACATGAAGAACAAGCTGGGGATCTTCAGACGGCGGAATGAGTC
CCCTGGAGCCCCTCCCGCGGGCAAGGCAGACAAAATGATGAAGTCATTCAAGCCCACCTCAGAGGAAGCCCTCAAGTGGGGCGAGTCCTT
GGAGAAGCTGCTGGTTCACAAATACGGGTTAGCAGTGTTCCAAGCCTTCCTTCGCACTGAGTTCAGTGAGGAGAATCTGGAGTTCTGGTT
GGCTTGTGAGGACTTCAAGAAGGTCAAGTCACAGTCCAAGATGGCATCCAAGGCCAAGAAGATCTTTGCTGAATACATCGCGATCCAGGC
ATGCAAGGAGGTCAACCTGGACTCCTACACGCGGGAGCACACCAAGGACAACCTGCAGAGCGTCACGCGGGGCTGCTTCGACCTGGCACA
GAAGCGCATCTTCGGGCTCATGGAAAAGGACTCGTACCCTCGCTTTCTCCGTTCTGACCTCTACCTGGACCTTATTAACCAGAAGAAGAT
GAGTCCCCCGCTTTAGGGGCCACTGGAGTCGAGCTCAGCGTTCACACCAGGCGGGCTGGGTCCCCTGCCCACCTGCCTCCCTGCCCCCTG
TGACGGAGGGGGCAAGCAAGCCCCCAGAGGCTGTGTCTCTGGACAGACGGATAGACATACGGAAGCGAGGCCTGGACCAAGAGAGGCCCA
GGCTACTGGAGGAGTAGAAGGATGGGCCCCGTGGGGTCCCCACTGCCCCGGTACGAGGGGGCCCAAGACCCTGGCAGGTCAGGGGCCCTG
GCCAAGCCAGATCTGGAGCTGCTGCTCCCTGCTGCGGAGACCGCGGAGGCTTCGCGTTGACCAAGTTCCTTAAAGAACTGGCTGATGGGG
CAGGAGGTCCAGGCCTGGGCTCTCGGGCCCTCCTAGAGGGCCATTGGAGCTTGCAGCTCAGACCCCCACTTTGAGTTTTATTTATTTAAA
TAGTAGTTGGATGCTTGGCACGTCGTCCTGTAATAGGAAACCCTTGCCTCATCAGTTTTCCTGATTTACAAGTGCAATATTTTAGCCAAT
GCCTTGGGAGAAGCTGCCATGCAAAGGTGGACACCATTCTCCAGCTTCAGGGGATATGCTCGTCCCGGGCACCGGTGGCAGGCAGCTGGC
CTTCTGGACTAAGGCAGCCTGGGGGGACACTGCAGTCTGGCTACACACAGAGATCTGGCACCCCCTGGGTGGAGTGTCCCTCGGGGGCTT

>56681_56681_3_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000350696_length(amino acids)=583AA_BP=23
MRSSPSSPAAGPGEDATAARVTMKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSP
PSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPL
LTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEA
EEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWG
MPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSE
EALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSV

--------------------------------------------------------------
>56681_56681_4_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000374136_length(transcript)=1298nt_BP=403nt
ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC
GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC
GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA
GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC
AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGAAGGCAGAGTGCTTATTCACTTTGGAAGCGCACTCGCAGGAGCAGAA
GAAGAGAGTGTGCTGGTGCCTGTCGGAGAACATCGCCAAGCAGCAACAGCTGGCAGCATCACCCCCGGACAGCAAGAAACTCCACCCTTT
CGGCTCTCTCCAGCAGGAGATGGGGCCGGTCAACTCAACCAATGCCACCCAGGATAGAAGCTTTACCTCACCAGGACAGACTCTGATTGG
CTGAGCAAACCCAAGGGCGGGACTCTGCTTCTGGCAACTTAACCCTTTCTTGGGCATCCCCTACCACACAGTAACCTCACCTCAACTGGA
CCTGAAACAGAGGACCAAGATGGTGGGTCTAGGGTCATCTGAAGGGAGTGGTCCCAAGGGTGCATGTGGATGTCAACAGAAGGACCACAA
TGGTGTGAGAGGCCTTGTGGGCATGCAGAGACTGGCAGCAGAAAGTCCCAAGAGGAGAGGACTCAGAGGCTTCTTCCTTCCAAGGAGGAG
GAGGAGGAGGACATTCCACATCTGGGCTTCCAGTGGTGGCTCCCGGACCTGCCTTGGGGGCAGCAGGAGAGGTTGGGAGAGGTCACCCTG
ATGAAGAACAATGCCATGATCTGCTGCTGCCAGAGGACATCTCCGCCCATCCACTCATTTTCCACCTGTACACATTGGCTCATTCATTCG
ATGGATATTTCGGGTGCATCTACTTTATGCCAGGCTCTATGCTAGGAGCTGGGGATACTGTGGAGAAAAAGTCGGATATGGTCTCGCTCT
CATCAAGATTTCAGTCTAGCTGGGAGTGAGCGTTAAATAAGTCAATACCAACACACACACGTGCACACACGTGATGGCAAGCTGTGATCA

>56681_56681_4_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000374136_length(amino acids)=159AA_BP=0
MPKKGLSCQKQSPALGFAQPIRVCPGEVKLLSWVALVELTGPISCWREPKGWSFLLSGGDAASCCCLAMFSDRHQHTLFFCSCECASKVN

--------------------------------------------------------------
>56681_56681_5_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000374140_length(transcript)=2871nt_BP=403nt
ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC
GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC
GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA
GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC
AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGAAGGCAGAGTGCTTATTCACTTTGGAAGCGCACTCGCAGGAGCAGAA
GAAGAGAGTGTGCTGGTGCCTGTCGGAGAACATCGCCAAGCAGCAACAGCTGGCAGCATCACCCCCGGACAGCAAGATGTTTGAGACGGA
GGCAGATGAGAAGAGGGAGATGGCCTTGGAGGAAGGGAAGGGGCCTGGTGCCGAGGATTCCCCACCCAGCAAGGAGCCCTCTCCTGGCCA
GGAGCTTCCTCCAGGACAAGACCTTCCACCCAACAAGGACTCCCCTTCTGGGCAGGAACCCGCTCCCAGCCAAGAACCACTGTCCAGCAA
AGACTCAGCTACCTCTGAAGGATCCCCTCCAGGCCCAGATGCTCCGCCCAGCAAGGATGTGCCACCATGCCAGGAACCCCCTCCAGCCCA
AGACCTCTCACCCTGCCAGGACCTACCTGCTGGTCAAGAACCCCTGCCTCACCAGGACCCTCTACTCACCAAAGACCTCCCTGCCATCCA
GGAATCCCCCACCCGGGACCTTCCACCCTGTCAAGATCTGCCTCCTAGCCAGGTCTCCCTGCCAGCCAAGGCCCTTACTGAGGACACCAT
GAGCTCCGGGGACCTACTAGCAGCTACTGGGGACCCACCTGCGGCCCCCAGGCCAGCCTTCGTGATCCCTGAGGTCCGGCTGGATAGCAC
CTACAGCCAGAAGGCAGGGGCAGAGCAGGGCTGCTCGGGAGATGAGGAGGATGCAGAAGAGGCCGAGGAGGTGGAGGAGGGGGAGGAAGG
GGAGGAGGACGAGGATGAGGACACCAGCGATGACAACTACGGAGAGCGCAGTGAGGCCAAGCGCAGCAGCATGATCGAGACGGGCCAGGG
GGCTGAGGGTGGCCTCTCACTGCGTGTGCAGAACTCGCTGCGGCGCCGGACGCACAGCGAGGGCAGCCTGCTGCAGGAGCCCCGAGGGCC
CTGCTTTGCCTCCGACACCACCTTGCACTGCTCAGACGGTGAGGGCGCCGCCTCCACCTGGGGCATGCCTTCGCCCAGCACCCTCAAGAA
AGAGCTGGGCCGCAATGGTGGCTCCATGCACCACCTTTCCCTCTTCTTCACAGGACACAGGAAGATGAGCGGGGCTGACACCGTTGGGGA
TGATGACGAAGCCTCCCGGAAGAGAAAGAGCAAAAACCTAGCCAAGGACATGAAGAACAAGCTGGGGATCTTCAGACGGCGGAATGAGTC
CCCTGGAGCCCCTCCCGCGGGCAAGGCAGACAAAATGATGAAGTCATTCAAGCCCACCTCAGAGGAAGCCCTCAAGTGGGGCGAGTCCTT
GGAGAAGCTGCTGGTTCACAAATACGGGTTAGCAGTGTTCCAAGCCTTCCTTCGCACTGAGTTCAGTGAGGAGAATCTGGAGTTCTGGTT
GGCTTGTGAGGACTTCAAGAAGGTCAAGTCACAGTCCAAGATGGCATCCAAGGCCAAGAAGATCTTTGCTGAATACATCGCGATCCAGGC
ATGCAAGGAGGTCAACCTGGACTCCTACACGCGGGAGCACACCAAGGACAACCTGCAGAGCGTCACGCGGGGCTGCTTCGACCTGGCACA
GAAGCGCATCTTCGGGCTCATGGAAAAGGACTCGTACCCTCGCTTTCTCCGTTCTGACCTCTACCTGGACCTTATTAACCAGAAGAAGAT
GAGTCCCCCGCTTTAGGGGCCACTGGAGTCGAGCTCAGCGTTCACACCAGGCGGGCTGGGTCCCCTGCCCACCTGCCTCCCTGCCCCCTG
TGACGGAGGGGGCAAGCAAGCCCCCAGAGGCTGTGTCTCTGGACAGACGGATAGACATACGGAAGCGAGGCCTGGACCAAGAGAGGCCCA
GGCTACTGGAGGAGTAGAAGGATGGGCCCCGTGGGGTCCCCACTGCCCCGGTACGAGGGGGCCCAAGACCCTGGCAGGTCAGGGGCCCTG
GCCAAGCCAGATCTGGAGCTGCTGCTCCCTGCTGCGGAGACCGCGGAGGCTTCGCGTTGACCAAGTTCCTTAAAGAACTGGCTGATGGGG
CAGGAGGTCCAGGCCTGGGCTCTCGGGCCCTCCTAGAGGGCCATTGGAGCTTGCAGCTCAGACCCCCACTTTGAGTTTTATTTATTTAAA
TAGTAGTTGGATGCTTGGCACGTCGTCCTGTAATAGGAAACCCTTGCCTCATCAGTTTTCCTGATTTACAAGTGCAATATTTTAGCCAAT
GCCTTGGGAGAAGCTGCCATGCAAAGGTGGACACCATTCTCCAGCTTCAGGGGATATGCTCGTCCCGGGCACCGGTGGCAGGCAGCTGGC
CTTCTGGACTAAGGCAGCCTGGGGGGACACTGCAGTCTGGCTACACACAGAGATCTGGCACCCCCTGGGTGGAGTGTCCCTCGGGGGCTT

>56681_56681_5_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000374140_length(amino acids)=583AA_BP=23
MRSSPSSPAAGPGEDATAARVTMKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSP
PSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPL
LTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEA
EEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWG
MPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSE
EALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSV

--------------------------------------------------------------
>56681_56681_6_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000394646_length(transcript)=1885nt_BP=403nt
ATTTATGGACAGATTGCCCGGCCCGAGCCGAGACTCAGCCAGAGGAGTACGGATTAAGTGGCCGAAGAAAGAGGAGTGAGGCAGGGGAGC
GAGGCGGACGCTCCGAGCGCATCGGACTCACCTGGGCCGGCGGCGACCGGCGAGTACGAGTGGACTCTTGCCCTCCGCAGCATGCGCCCC
GCCTGCTAAGTCGCCGCCGTCTCGCCCTCACCTAGCACCGCCAATCCCGCCTGGATGGAGTCCCCTCTGGGTTCCCATTGGCTCCTGTGA
GTGCTTGGGTGTCGGGAGCCTGTTTTTGGCGAGGGGAACCAACTTTTGAAGTTCGCCCAGAAGACTGCGTTCCAGCCCCAGTTCCCCGGC
AGCGGGACCCGGCGAAGACGCGACCGCGGCGCGAGTCACCATGAAGGCAGAGTGCTTATTCACTTTGGAAGCGCACTCGCAGGAGCAGAA
GAAGAGAGTGTGCTGGTGCCTGTCGGAGAACATCGCCAAGCAGCAACAGCTGGCAGCATCACCCCCGGACAGCAAGATGAGCGGGGCTGA
CACCGTTGGGGATGATGACGAAGCCTCCCGGAAGAGAAAGAGCAAAAACCTAGCCAAGGACATGAAGAACAAGCTGGGGATCTTCAGACG
GCGGAATGAGTCCCCTGGAGCCCCTCCCGCGGGCAAGGCAGACAAAATGATGAAGTCATTCAAGCCCACCTCAGAGGAAGCCCTCAAGTG
GGGCGAGTCCTTGGAGAAGCTGCTGGTTCACAAATACGGGTTAGCAGTGTTCCAAGCCTTCCTTCGCACTGAGTTCAGTGAGGAGAATCT
GGAGTTCTGGTTGGCTTGTGAGGACTTCAAGAAGGTCAAGTCACAGTCCAAGATGGCATCCAAGGCCAAGAAGATCTTTGCTGAATACAT
CGCGATCCAGGCATGCAAGGAGGTCAACCTGGACTCCTACACGCGGGAGCACACCAAGGACAACCTGCAGAGCGTCACGCGGGGCTGCTT
CGACCTGGCACAGAAGCGCATCTTCGGGCTCATGGAAAAGGACTCGTACCCTCGCTTTCTCCGTTCTGACCTCTACCTGGACCTTATTAA
CCAGAAGAAGATGAGTCCCCCGCTTTAGGGGCCACTGGAGTCGAGCTCAGCGTTCACACCAGGCGGGCTGGGTCCCCTGCCCACCTGCCT
CCCTGCCCCCTGTGACGGAGGGGGCAAGCAAGCCCCCAGAGGCTGTGTCTCTGGACAGACGGATAGACATACGGAAGCGAGGCCTGGACC
AAGAGAGGCCCAGGCTACTGGAGGAGTAGAAGGATGGGCCCCGTGGGGTCCCCACTGCCCCGGTACGAGGGGGCCCAAGACCCTGGCAGG
TCAGGGGCCCTGGCCAAGCCAGATCTGGAGCTGCTGCTCCCTGCTGCGGAGACCGCGGAGGCTTCGCGTTGACCAAGTTCCTTAAAGAAC
TGGCTGATGGGGCAGGAGGTCCAGGCCTGGGCTCTCGGGCCCTCCTAGAGGGCCATTGGAGCTTGCAGCTCAGACCCCCACTTTGAGTTT
TATTTATTTAAATAGTAGTTGGATGCTTGGCACGTCGTCCTGTAATAGGAAACCCTTGCCTCATCAGTTTTCCTGATTTACAAGTGCAAT
ATTTTAGCCAATGCCTTGGGAGAAGCTGCCATGCAAAGGTGGACACCATTCTCCAGCTTCAGGGGATATGCTCGTCCCGGGCACCGGTGG
CAGGCAGCTGGCCTTCTGGACTAAGGCAGCCTGGGGGGACACTGCAGTCTGGCTACACACAGAGATCTGGCACCCCCTGGGTGGAGTGTC

>56681_56681_6_MYO1E-RGS3_MYO1E_chr15_59664697_ENST00000288235_RGS3_chr9_116299076_ENST00000394646_length(amino acids)=257AA_BP=23
MRSSPSSPAAGPGEDATAARVTMKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDSKMSGADTVGDDDEASRKRKSKNLAKDM
KNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYO1E-RGS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO1E-RGS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO1E-RGS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource