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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MYO1F-WRN (FusionGDB2 ID:56694)

Fusion Gene Summary for MYO1F-WRN

Fusion gene summary

Fusion gene information	Fusion gene name: MYO1F-WRN
	Fusion gene ID: 56694
		Hgene	Tgene
	Gene symbol	MYO1F	WRN
	Gene ID	4542	7486
	Gene name	myosin IF	WRN RecQ like helicase
	Synonyms	-	RECQ3\|RECQL2\|RECQL3
	Cytomap	19p13.2	8p12
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-Ifmyosin-IDmyosin-Ie	Werner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome RecQ like helicaseWerner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000338257, ENST00000595046,	ENST00000298139,
Fusion gene scores	* DoF score	7 X 5 X 6=210	9 X 10 X 7=630
	# samples	7	11
	** MAII score	log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MYO1F [Title/Abstract] AND WRN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MYO1F(8616624)-WRN(30942682), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	WRN	GO:0000731	DNA synthesis involved in DNA repair	17563354
Tgene	WRN	GO:0006259	DNA metabolic process	16622405
Tgene	WRN	GO:0006284	base-excision repair	17611195
Tgene	WRN	GO:0006974	cellular response to DNA damage stimulus	18203716
Tgene	WRN	GO:0006979	response to oxidative stress	17611195
Tgene	WRN	GO:0009267	cellular response to starvation	11420665
Tgene	WRN	GO:0010225	response to UV-C	17563354
Tgene	WRN	GO:0031297	replication fork processing	17115688
Tgene	WRN	GO:0032508	DNA duplex unwinding	11735402\|26420422
Tgene	WRN	GO:0044806	G-quadruplex DNA unwinding	11735402
Tgene	WRN	GO:0051345	positive regulation of hydrolase activity	17611195
Tgene	WRN	GO:0061820	telomeric D-loop disassembly	15200954\|19734539\|26420422
Tgene	WRN	GO:0071480	cellular response to gamma radiation	21639834
Tgene	WRN	GO:0098530	positive regulation of strand invasion	26420422
Tgene	WRN	GO:1902570	protein localization to nucleolus	11420665

Fusion gene breakpoints across MYO1F (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-B8-5163-01A	MYO1F	chr19	8616624	-	WRN	chr8	30942682	+

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Fusion Gene ORF analysis for MYO1F-WRN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000338257	ENST00000298139	MYO1F	chr19	8616624	-	WRN	chr8	30942682	+
intron-3CDS	ENST00000595046	ENST00000298139	MYO1F	chr19	8616624	-	WRN	chr8	30942682	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000338257

MYO1F

chr19

8616624

ENST00000298139

WRN

chr8

30942682

4655

1039

202

3987

1261

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338257	ENST00000298139	MYO1F	chr19	8616624	-	WRN	chr8	30942682	+	0.000161695	0.99983823

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Fusion Genomic Features for MYO1F-WRN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO1F-WRN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:8616624/chr8:30942682)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO1F

chr19:8616624

chr8:30942682

ENST00000338257

110_117

257

1099.0

Nucleotide binding

ATP

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

507_510

450

1433.0

Compositional bias

Note=Poly-Glu

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

1150_1229

450

1433.0

Domain

HRDC

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

558_724

450

1433.0

Domain

Helicase ATP-binding

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

749_899

450

1433.0

Domain

Helicase C-terminal

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

668_671

450

1433.0

Motif

Note=DEAH box

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

571_578

450

1433.0

Nucleotide binding

ATP

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

451_477

450

1433.0

Repeat

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO1F

chr19:8616624

chr8:30942682

ENST00000338257

1041_1098

257

1099.0

Domain

SH3

Hgene

MYO1F

chr19:8616624

chr8:30942682

ENST00000338257

17_690

257

1099.0

Domain

Myosin motor

Hgene

MYO1F

chr19:8616624

chr8:30942682

ENST00000338257

693_722

257

1099.0

Domain

Hgene

MYO1F

chr19:8616624

chr8:30942682

ENST00000338257

728_917

257

1099.0

Domain

TH1

Hgene

MYO1F

chr19:8616624

chr8:30942682

ENST00000338257

579_589

257

1099.0

Region

Actin-binding

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

60_228

450

1433.0

Domain

Note=3'-5' exonuclease

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

424_477

450

1433.0

Region

Note=2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K

Tgene

WRN

chr19:8616624

chr8:30942682

ENST00000298139

424_450

450

1433.0

Repeat

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Fusion Gene Sequence for MYO1F-WRN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>56694_56694_1_MYO1F-WRN_MYO1F_chr19_8616624_ENST00000338257_WRN_chr8_30942682_ENST00000298139_length(transcript)=4655nt_BP=1039nt
ATCAAGTTCTGACCCCTCCCTTCAGGCTCAGAGCCCCAAACAGCCAGCTCCCCGCCCCCCTCCACACCCAGCTTCCCTCCCCCATGGCCT
CGGCCCCTCCCGCCAAAGGAAGTGAGAAGGGGCTGTTGTAAGAGGAACTAAAGCCGGGAGTCCGGTGAACGGGCAGAAGCAGGGCCATGC
CCAAGCCACCCCCAAGATCCCCCTGAACCTGCACCTCCATCACGACCCATTCAGGAGCCTCCAGGAGCCCAGACACCAGCCCCCCACCAT
GGGCAGCAAGGAGCGCTTCCACTGGCAGAGCCACAACGTGAAGCAGAGCGGCGTGGATGACATGGTGCTTCTTCCCCAGATCACCGAAGA
CGCCATTGCCGCCAACCTCCGGAAGCGCTTCATGGACGACTACATCTTCACCTACATCGGCTCTGTGCTCATCTCTGTAAACCCCTTCAA
GCAGATGCCCTACTTCACCGACCGTGAGATCGACCTCTATCAGGGCGCGGCCCAGTATGAGAATCCCCCGCACATCTACGCCCTCACGGA
CAACATGTACCGGAACATGCTTATCGACTGTGAGAACCAGTGTGTCATCATTAGTGGAGAGAGTGGAGCTGGGAAGACAGTGGCAGCCAA
ATATATCATGGGCTACATCTCCAAGGTGTCTGGCGGAGGCGAGAAGGTCCAGCACGTCAAAGATATCATCCTGCAGTCCAACCCGCTGCT
CGAGGCCTTCGGCAACGCCAAGACTGTGCGCAACAACAATTCCAGCCGCTTTGGCAAGTACTTTGAGATCCAGTTCAGCCGAGGTGGGGA
GCCAGATGGGGGCAAGATCTCCAACTTCTTGCTGGAGAAGTCCCGCGTGGTCATGCAAAATGAAAATGAGAGGAACTTCCACATCTACTA
CCAGCTGCTGGAAGGGGCCTCCCAGGAGCAAAGGCAGAACCTGGGCCTCATGACACCGGACTACTATTACTACCTCAACCAATCGGACAC
CTACCAGGTGGACGGCACGGACGACAGAAGCGACTTTGGTGAGACTCTGCATTTATCTCCCAATGATAATGAAAACGATACGTCCTATGT
AATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAAAACCTCAATAGTGGCACGGTAGAACCAACTCATTCTAAATG
CTTAAAAATGGAAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAATGAAGGGGAAGAAGATGATGA
TAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTCAAGATGTACTTTGGCCATTCCAGTTTTAAACCAGTTCAGTG
GAAAGTGATTCATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAGAGTTTGTGCTTCCAGTATCC
ACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCTCTGATGGAAGACCAAGTGCTACAGCTTAAAATGTCCAACAT
CCCAGCTTGCTTCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGGATTGTATACGTAACTCCAGA
ATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATTGGTATCACGCTCATTGCTGTGGATGAGGCTCACTGTATTTC
TGAGTGGGGGCATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTTCCAATCGTTGCACTTACTGC
TACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTGAGAAATCCTCAGATCACCTGTACTGGTTTTGATCGACCAAA
CCTGTATTTAGAAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACAAGTTCCCACTGGGAATTTGA
AGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTTACAGGTGAACTTAGGAAACTGAATCTATCCTGTGGAACATA
CCATGCGGGCATGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGTGTCATAGCTACCATAGCTTT
TGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGTGCTCCTAAGGACATGGAATCATATTATCAGGAGATTGGTAG
AGCTGGTCGTGATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGGCACCTTCTTACTGAGATACG
TAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAAAAATATCTTCATTCTAGCAGATGTAGGAGACAAATCATCTT
GTCTCATTTTGAGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGATAATTGCAGGTCCAGATTGGA
TCATTGCTATTCCATGGATGACTCAGAGGATACATCCTGGGACTTTGGTCCACAAGCATTTAAGCTTTTGTCTGCTGTGGACATCTTAGG
CGAAAAATTTGGAATTGGGCTTCCAATTTTATTTCTCCGAGGATCTAATTCTCAGCGTCTTGCCGATCAATATCGCAGGCACAGTTTATT
TGGCACTGGCAAGGATCAAACAGAGAGTTGGTGGAAGGCTTTTTCCCGTCAGCTGATCACTGAGGGATTCTTGGTAGAAGTTTCTCGGTA
TAACAAATTTATGAAGATTTGCGCCCTTACGAAAAAGGGTAGAAATTGGCTTCATAAAGCTAATACAGAATCTCAGAGCCTCATCCTTCA
AGCTAATGAAGAATTGTGTCCAAAGAAGTTGCTTCTGCCTAGTTCGAAAACTGTATCTTCGGGCACCAAAGAGCATTGTTATAATCAAGT
ACCAGTTGAATTAAGTACAGAGAAGAAGTCTAACTTGGAGAAGTTATATTCTTATAAACCATGTGATAAGATTTCTTCTGGGAGTAACAT
TTCTAAAAAAAGTATCATGGTACAGTCACCAGAAAAAGCTTACAGTTCCTCACAGCCTGTTATTTCGGCACAAGAGCAGGAGACTCAGAT
TGTGTTATATGGCAAATTGGTAGAAGCTAGGCAGAAACATGCCAATAAAATGGATGTTCCCCCAGCTATTCTGGCAACAAACAAGATACT
GGTGGATATGGCCAAAATGAGACCAACTACGGTTGAAAACGTAAAAAGGATTGATGGTGTTTCTGAAGGCAAAGCTGCCATGTTGGCCCC
TCTGTTGGAAGTCATCAAACATTTCTGCCAAACAAATAGTGTTCAGACAGACCTCTTTTCAAGTACAAAACCTCAAGAAGAACAGAAGAC
GAGTCTGGTAGCAAAAAATAAAATATGCACACTTTCACAGTCTATGGCCATCACATACTCTTTATTCCAAGAAAAGAAGATGCCTTTGAA
GAGCATAGCTGAGAGCAGGATTCTGCCTCTCATGACAATTGGCATGCACTTATCCCAAGCGGTGAAAGCTGGCTGCCCCCTTGATTTGGA
GCGAGCAGGCCTGACTCCAGAGGTTCAGAAGATTATTGCTGATGTTATCCGAAACCCTCCCGTCAACTCAGATATGAGTAAAATTAGCCT
AATCAGAATGTTAGTTCCTGAAAACATTGACACGTACCTTATCCACATGGCAATTGAGATCCTTAAACATGGTCCTGACAGCGGACTTCA
ACCTTCATGTGATGTCAACAAAAGGAGATGTTTTCCCGGTTCTGAAGAGATCTGTTCAAGTTCTAAGAGAAGCAAGGAAGAAGTAGGCAT
CAATACTGAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGGACAA
AACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATTTTAT
TTCTGAAGAGTAAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCATCTTAAATCAGC
CTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAAGATT
GCTTTAAGAAACTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGATTTGATATAGAT
AACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATAGTTA
TTTTACAAATTGTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGAAAATGAAACCG
CATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTATTTTA

>56694_56694_1_MYO1F-WRN_MYO1F_chr19_8616624_ENST00000338257_WRN_chr8_30942682_ENST00000298139_length(amino acids)=1261AA_BP=279
MNLHLHHDPFRSLQEPRHQPPTMGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTD
REIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAK
TVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTD
DRSDFGETLHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPA
PNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGS
AQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIR
EDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFS
TRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLY
KLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGL
PILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCP
KKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLV
EARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNK
ICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPE
NIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYO1F-WRN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	WRN	chr19:8616624	chr8:30942682	ENST00000298139		9	35	987_993	450.0	1433.0	DNA

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	WRN	chr19:8616624	chr8:30942682	ENST00000298139		9	35	2_277	450.0	1433.0	WRNIP1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MYO1F-WRN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MYO1F-WRN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source