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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MYO5A-ROS1 (FusionGDB2 ID:56714) |
Fusion Gene Summary for MYO5A-ROS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYO5A-ROS1 | Fusion gene ID: 56714 | Hgene | Tgene | Gene symbol | MYO5A | ROS1 | Gene ID | 4644 | 6098 |
| Gene name | myosin VA | ROS proto-oncogene 1, receptor tyrosine kinase | |
| Synonyms | GS1|MYH12|MYO5|MYR12 | MCF3|ROS|c-ros-1 | |
| Cytomap | 15q21.2 | 6q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional myosin-Vadilute myosin heavy chain, non-musclemyosin Vmyosin VA (heavy chain 12, myoxin)myosin, heavy polypeptide kinasemyosin-12myosin-Vamyoxin | proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | |
| Modification date | 20200313 | 20200314 | |
| UniProtAcc | Q9Y4I1 | P08922 | |
| Ensembl transtripts involved in fusion gene | ENST00000356338, ENST00000358212, ENST00000399231, ENST00000399233, ENST00000553916, | ENST00000368507, ENST00000368508, | |
| Fusion gene scores | * DoF score | 13 X 13 X 6=1014 | 18 X 20 X 5=1800 |
| # samples | 12 | 20 | |
| ** MAII score | log2(12/1014*10)=-3.07895134139482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1800*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYO5A [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | |||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ROS1 | GO:0001558 | regulation of cell growth | 16885344 |
| Tgene | ROS1 | GO:0006468 | protein phosphorylation | 16885344 |
| Tgene | ROS1 | GO:0032006 | regulation of TOR signaling | 16885344 |
| Fusion gene breakpoints across MYO5A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ROS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
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Fusion Gene ORF analysis for MYO5A-ROS1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000356338 | ENST00000368507 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000356338 | ENST00000368508 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000358212 | ENST00000368507 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000358212 | ENST00000368508 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000399231 | ENST00000368507 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000399231 | ENST00000368508 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000399233 | ENST00000368507 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000399233 | ENST00000368508 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000553916 | ENST00000368507 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000553916 | ENST00000368508 | MYO5A | chr15 | 52659227 | - | ROS1 | chr6 | 117642557 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000399231 | MYO5A | chr15 | 52659227 | - | ENST00000368508 | ROS1 | chr6 | 117642557 | - | 4999 | 3404 | 244 | 4806 | 1520 |
| ENST00000399231 | MYO5A | chr15 | 52659227 | - | ENST00000368507 | ROS1 | chr6 | 117642557 | - | 4999 | 3404 | 244 | 4806 | 1520 |
| ENST00000356338 | MYO5A | chr15 | 52659227 | - | ENST00000368508 | ROS1 | chr6 | 117642557 | - | 4829 | 3234 | 74 | 4636 | 1520 |
| ENST00000356338 | MYO5A | chr15 | 52659227 | - | ENST00000368507 | ROS1 | chr6 | 117642557 | - | 4829 | 3234 | 74 | 4636 | 1520 |
| ENST00000358212 | MYO5A | chr15 | 52659227 | - | ENST00000368508 | ROS1 | chr6 | 117642557 | - | 4755 | 3160 | 0 | 4562 | 1520 |
| ENST00000358212 | MYO5A | chr15 | 52659227 | - | ENST00000368507 | ROS1 | chr6 | 117642557 | - | 4755 | 3160 | 0 | 4562 | 1520 |
| ENST00000399233 | MYO5A | chr15 | 52659227 | - | ENST00000368508 | ROS1 | chr6 | 117642557 | - | 4999 | 3404 | 244 | 4806 | 1520 |
| ENST00000399233 | MYO5A | chr15 | 52659227 | - | ENST00000368507 | ROS1 | chr6 | 117642557 | - | 4999 | 3404 | 244 | 4806 | 1520 |
| ENST00000553916 | MYO5A | chr15 | 52659227 | - | ENST00000368508 | ROS1 | chr6 | 117642557 | - | 4790 | 3195 | 35 | 4597 | 1520 |
| ENST00000553916 | MYO5A | chr15 | 52659227 | - | ENST00000368507 | ROS1 | chr6 | 117642557 | - | 4790 | 3195 | 35 | 4597 | 1520 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MYO5A-ROS1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MYO5A-ROS1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:/chr6:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYO5A | ROS1 |
| FUNCTION: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. {ECO:0000269|PubMed:10448864}. | FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MYO5A-ROS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >56714_56714_1_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000356338_ROS1_chr6_117642557_ENST00000368507_length(transcript)=4829nt_BP=3234nt AGTCCGCTCGGGCGGCCGCCCAGGCGAGGTGCGGCCTCCGCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGC TCTACACAAAGTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATA AAGTCCTCCTGCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTG ACATACTTGTTGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATT CCAAACTTATTTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATG CATACAGTGGTCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAA ATCAGTCCATCATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTT CTGCCAGTGAGGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATA ATAGCAGCCGTTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGA AATCCAGAGTGGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAA TGCTACGATTAGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGG CACATACTAGGCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAG GCAATGTTGGATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTG TGGACTATGAGGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGG CCACAAATGCCCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTG CTGTCAAACAGCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATT ATGCAAATGAAAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACAC TCATAGATTTTTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGC CTAAAGGCACAGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACA AAGCTTTCATCATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAAC AAATTAAAGTTCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCT CCTCAGGGCGCACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGG GGCATCAGTTCAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACT TCAAGTTCCCATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCG GTTTCCCCTCACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAA CATGCAAGAATGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGG CCTATCTAGAAAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGT ACCTACGCATGCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCA AGGCAGCAACCATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGT CTTACTTGCGAGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCT GGCTGGCCCGCACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAA AGAAGCTCAAAATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAG TTGATGAGCAGAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAA GTGACTTAGAACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCC GGAAAGACCTGGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAA ATCTGAAGGAAGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGC ATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGG CAGCCGGAGTAGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGG AAAAACTGACTCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTG GAGAAATCAAAGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCA AATTTAATCATCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAG ACCTTCTTACTTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATA TTTCAAAAGGCTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATA CCAGTCCACGGATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGC TCCCAGTTCGGTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGG AGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCAC CAAGAAATTGTCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGG ACCAACTTCAGTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCT TTGAAGGTGAAGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAA ACTATATGGTACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGA GGAAAGAAGAGAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGA ACTATGCCTGTCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCAT TCAGTAGTTACTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCT >56714_56714_1_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000356338_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_2_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000356338_ROS1_chr6_117642557_ENST00000368508_length(transcript)=4829nt_BP=3234nt AGTCCGCTCGGGCGGCCGCCCAGGCGAGGTGCGGCCTCCGCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGC TCTACACAAAGTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATA AAGTCCTCCTGCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTG ACATACTTGTTGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATT CCAAACTTATTTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATG CATACAGTGGTCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAA ATCAGTCCATCATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTT CTGCCAGTGAGGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATA ATAGCAGCCGTTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGA AATCCAGAGTGGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAA TGCTACGATTAGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGG CACATACTAGGCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAG GCAATGTTGGATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTG TGGACTATGAGGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGG CCACAAATGCCCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTG CTGTCAAACAGCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATT ATGCAAATGAAAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACAC TCATAGATTTTTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGC CTAAAGGCACAGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACA AAGCTTTCATCATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAAC AAATTAAAGTTCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCT CCTCAGGGCGCACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGG GGCATCAGTTCAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACT TCAAGTTCCCATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCG GTTTCCCCTCACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAA CATGCAAGAATGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGG CCTATCTAGAAAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGT ACCTACGCATGCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCA AGGCAGCAACCATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGT CTTACTTGCGAGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCT GGCTGGCCCGCACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAA AGAAGCTCAAAATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAG TTGATGAGCAGAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAA GTGACTTAGAACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCC GGAAAGACCTGGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAA ATCTGAAGGAAGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGC ATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGG CAGCCGGAGTAGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGG AAAAACTGACTCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTG GAGAAATCAAAGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCA AATTTAATCATCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAG ACCTTCTTACTTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATA TTTCAAAAGGCTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATA CCAGTCCACGGATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGC TCCCAGTTCGGTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGG AGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCAC CAAGAAATTGTCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGG ACCAACTTCAGTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCT TTGAAGGTGAAGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAA ACTATATGGTACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGA GGAAAGAAGAGAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGA ACTATGCCTGTCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCAT TCAGTAGTTACTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCT >56714_56714_2_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000356338_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_3_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000358212_ROS1_chr6_117642557_ENST00000368507_length(transcript)=4755nt_BP=3160nt ATGAAATCTAGTAGTTTGGAAACTATGTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGAT TATAAGCCAGGAGATAAAGTCCTCCTGCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCT CACTTACGAAATCCTGACATACTTGTTGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGA GTCCGCTTTATTGATTCCAAACTTATTTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGA GAAGATATTATTAATGCATACAGTGGTCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATG GCCAGAGATGAACGAAATCAGTCCATCATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTT GCAACTGTGAGTGGTTCTGCCAGTGAGGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAA ACAACCAGGAATGATAATAGCAGCCGTTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGA ACTTATCTTTTAGAGAAATCCAGAGTGGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAG TTACCTGAATTTAAAATGCTACGATTAGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGAT GATGCAAAGGAGATGGCACATACTAGGCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCT GGCATCCTTCACTTAGGCAATGTTGGATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTC TGTGAACTCATGGGTGTGGACTATGAGGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCC ATCTCCAAGCTGCAGGCCACAAATGCCCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAAT CAGGCTCTCCATTCTGCTGTCAAACAGCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAA CAGTTTTGCATAAATTATGCAAATGAAAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAA CAAATTCCATGGACACTCATAGATTTTTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGAT GAGGAATGCAAGATGCCTAAAGGCACAGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAG CCTCGTCTATCAAACAAAGCTTTCATCATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGAC ACCGTTTTTGAAGAACAAATTAAAGTTCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGT CCAACTTCAGCCACCTCCTCAGGGCGCACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAG CACAAGAAAACAGTGGGGCATCAGTTCAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGT ATCAAGCCTAATGACTTCAAGTTCCCATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATC CGAATCAGTGCGGCCGGTTTCCCCTCACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTG AGTGACAGAAAGCAAACATGCAAGAATGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTC CGTGCCGGTCAAGTGGCCTATCTAGAAAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGG CTGCTGAGAAAGAAGTACCTACGCATGCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAG TTTCTGCGCAGAACCAAGGCAGCAACCATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCC ACTATCGTTCTTCAGTCTTACTTGCGAGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAG AAGCGAGTCCGGGGCTGGCTGGCCCGCACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATG GCCAAGCGTGAGCTAAAGAAGCTCAAAATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATG CAGCTGCAGCGCAAAGTTGATGAGCAGAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAG ACTGAGAAACTACGAAGTGACTTAGAACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAA GAAATTGCCAAGCTCCGGAAAGACCTGGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACA GAGCAGCTGGTATCAAATCTGAAGGAAGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAG GAGATGACAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCT GAGCTGCGAGGTCTGGCAGCCGGAGTAGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTT CCTGCCTTCCCTCGGGAAAAACTGACTCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATC TTAGGAGTTGGAAGTGGAGAAATCAAAGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAG GCACATCTGATGAGCAAATTTAATCATCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAA CTGATGGAGGGAGGAGACCTTCTTACTTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTA GACCTGTGTGTAGATATTTCAAAAGGCTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTT TCCGTGAAAGACTATACCAGTCCACGGATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAG AGAGGGGAAGGCCTGCTCCCAGTTCGGTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTT GGAATTCTGATTTGGGAGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGA GGGAGACTGGAGCCACCAAGAAATTGTCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACT TTTCATAGAATTCAGGACCAACTTCAGTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGA GTCATAAATGAAAGCTTTGAAGGTGAAGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAG AACCGAGAAGGGTTAAACTATATGGTACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCT GAATCTTGTGGTCTGAGGAAAGAAGAGAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGC AAGCCTGAAGGCCTGAACTATGCCTGTCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTG AGATAAACACTCTCATTCAGTAGTTACTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGC >56714_56714_3_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000358212_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=1520AA_BP=1053 MKSSSLETMFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_4_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000358212_ROS1_chr6_117642557_ENST00000368508_length(transcript)=4755nt_BP=3160nt ATGAAATCTAGTAGTTTGGAAACTATGTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGAT TATAAGCCAGGAGATAAAGTCCTCCTGCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCT CACTTACGAAATCCTGACATACTTGTTGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGA GTCCGCTTTATTGATTCCAAACTTATTTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGA GAAGATATTATTAATGCATACAGTGGTCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATG GCCAGAGATGAACGAAATCAGTCCATCATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTT GCAACTGTGAGTGGTTCTGCCAGTGAGGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAA ACAACCAGGAATGATAATAGCAGCCGTTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGA ACTTATCTTTTAGAGAAATCCAGAGTGGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAG TTACCTGAATTTAAAATGCTACGATTAGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGAT GATGCAAAGGAGATGGCACATACTAGGCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCT GGCATCCTTCACTTAGGCAATGTTGGATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTC TGTGAACTCATGGGTGTGGACTATGAGGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCC ATCTCCAAGCTGCAGGCCACAAATGCCCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAAT CAGGCTCTCCATTCTGCTGTCAAACAGCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAA CAGTTTTGCATAAATTATGCAAATGAAAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAA CAAATTCCATGGACACTCATAGATTTTTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGAT GAGGAATGCAAGATGCCTAAAGGCACAGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAG CCTCGTCTATCAAACAAAGCTTTCATCATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGAC ACCGTTTTTGAAGAACAAATTAAAGTTCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGT CCAACTTCAGCCACCTCCTCAGGGCGCACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAG CACAAGAAAACAGTGGGGCATCAGTTCAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGT ATCAAGCCTAATGACTTCAAGTTCCCATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATC CGAATCAGTGCGGCCGGTTTCCCCTCACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTG AGTGACAGAAAGCAAACATGCAAGAATGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTC CGTGCCGGTCAAGTGGCCTATCTAGAAAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGG CTGCTGAGAAAGAAGTACCTACGCATGCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAG TTTCTGCGCAGAACCAAGGCAGCAACCATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCC ACTATCGTTCTTCAGTCTTACTTGCGAGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAG AAGCGAGTCCGGGGCTGGCTGGCCCGCACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATG GCCAAGCGTGAGCTAAAGAAGCTCAAAATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATG CAGCTGCAGCGCAAAGTTGATGAGCAGAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAG ACTGAGAAACTACGAAGTGACTTAGAACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAA GAAATTGCCAAGCTCCGGAAAGACCTGGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACA GAGCAGCTGGTATCAAATCTGAAGGAAGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAG GAGATGACAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCT GAGCTGCGAGGTCTGGCAGCCGGAGTAGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTT CCTGCCTTCCCTCGGGAAAAACTGACTCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATC TTAGGAGTTGGAAGTGGAGAAATCAAAGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAG GCACATCTGATGAGCAAATTTAATCATCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAA CTGATGGAGGGAGGAGACCTTCTTACTTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTA GACCTGTGTGTAGATATTTCAAAAGGCTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTT TCCGTGAAAGACTATACCAGTCCACGGATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAG AGAGGGGAAGGCCTGCTCCCAGTTCGGTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTT GGAATTCTGATTTGGGAGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGA GGGAGACTGGAGCCACCAAGAAATTGTCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACT TTTCATAGAATTCAGGACCAACTTCAGTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGA GTCATAAATGAAAGCTTTGAAGGTGAAGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAG AACCGAGAAGGGTTAAACTATATGGTACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCT GAATCTTGTGGTCTGAGGAAAGAAGAGAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGC AAGCCTGAAGGCCTGAACTATGCCTGTCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTG AGATAAACACTCTCATTCAGTAGTTACTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGC >56714_56714_4_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000358212_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=1520AA_BP=1053 MKSSSLETMFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_5_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399231_ROS1_chr6_117642557_ENST00000368507_length(transcript)=4999nt_BP=3404nt ACCCCGGGCAGGTGGAGCGCTCGCGGCTGCTCGCGGCGAGCCCGGGAGTGATGGCGAGGCCCCTGCGGGCGGCCAGCGCCTGAGGCGCCC CGCCCCGCCCCGCCCCGCGCGGCCCTCCCCGCCCGGCCCTGCCCTGCCCTGCTCCCTGCCGGCGGCTGCGGGCGCTTCCTAGTCCGCTCG GGCGGCCGCCCAGGCGAGGTGCGGCCTCCGCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGCTCTACACAAA GTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATAAAGTCCTCCT GCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTGACATACTTGT TGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATTCCAAACTTAT TTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATGCATACAGTGG TCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAAATCAGTCCAT CATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTTCTGCCAGTGA GGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATAATAGCAGCCG TTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGAAATCCAGAGT GGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAATGCTACGATT AGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGGCACATACTAG GCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAGGCAATGTTGG ATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTGTGGACTATGA GGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGGCCACAAATGC CCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTGCTGTCAAACA GCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATTATGCAAATGA AAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACACTCATAGATTT TTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGCCTAAAGGCAC AGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACAAAGCTTTCAT CATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAACAAATTAAAGT TCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCTCCTCAGGGCG CACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGGGGCATCAGTT CAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACTTCAAGTTCCC ATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCGGTTTCCCCTC ACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAACATGCAAGAA TGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGGCCTATCTAGA AAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGTACCTACGCAT GCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCAAGGCAGCAAC CATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGTCTTACTTGCG AGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCTGGCTGGCCCG CACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAAAGAAGCTCAA AATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAGTTGATGAGCA GAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAAGTGACTTAGA ACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCCGGAAAGACCT GGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAAATCTGAAGGA AGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGCATAGAAGATT AAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGGCAGCCGGAGT AGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGAC TCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAA AGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCA TCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTAC TTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGG CTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACG GATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCG GTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAAC TCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTG TCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCA GTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGA AGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGT ACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGA GAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTG TCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTA CTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTT >56714_56714_5_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399231_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_6_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399231_ROS1_chr6_117642557_ENST00000368508_length(transcript)=4999nt_BP=3404nt ACCCCGGGCAGGTGGAGCGCTCGCGGCTGCTCGCGGCGAGCCCGGGAGTGATGGCGAGGCCCCTGCGGGCGGCCAGCGCCTGAGGCGCCC CGCCCCGCCCCGCCCCGCGCGGCCCTCCCCGCCCGGCCCTGCCCTGCCCTGCTCCCTGCCGGCGGCTGCGGGCGCTTCCTAGTCCGCTCG GGCGGCCGCCCAGGCGAGGTGCGGCCTCCGCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGCTCTACACAAA GTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATAAAGTCCTCCT GCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTGACATACTTGT TGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATTCCAAACTTAT TTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATGCATACAGTGG TCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAAATCAGTCCAT CATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTTCTGCCAGTGA GGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATAATAGCAGCCG TTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGAAATCCAGAGT GGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAATGCTACGATT AGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGGCACATACTAG GCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAGGCAATGTTGG ATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTGTGGACTATGA GGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGGCCACAAATGC CCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTGCTGTCAAACA GCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATTATGCAAATGA AAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACACTCATAGATTT TTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGCCTAAAGGCAC AGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACAAAGCTTTCAT CATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAACAAATTAAAGT TCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCTCCTCAGGGCG CACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGGGGCATCAGTT CAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACTTCAAGTTCCC ATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCGGTTTCCCCTC ACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAACATGCAAGAA TGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGGCCTATCTAGA AAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGTACCTACGCAT GCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCAAGGCAGCAAC CATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGTCTTACTTGCG AGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCTGGCTGGCCCG CACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAAAGAAGCTCAA AATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAGTTGATGAGCA GAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAAGTGACTTAGA ACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCCGGAAAGACCT GGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAAATCTGAAGGA AGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGCATAGAAGATT AAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGGCAGCCGGAGT AGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGAC TCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAA AGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCA TCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTAC TTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGG CTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACG GATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCG GTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAAC TCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTG TCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCA GTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGA AGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGT ACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGA GAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTG TCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTA CTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTT >56714_56714_6_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399231_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_7_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399233_ROS1_chr6_117642557_ENST00000368507_length(transcript)=4999nt_BP=3404nt ACCCCGGGCAGGTGGAGCGCTCGCGGCTGCTCGCGGCGAGCCCGGGAGTGATGGCGAGGCCCCTGCGGGCGGCCAGCGCCTGAGGCGCCC CGCCCCGCCCCGCCCCGCGCGGCCCTCCCCGCCCGGCCCTGCCCTGCCCTGCTCCCTGCCGGCGGCTGCGGGCGCTTCCTAGTCCGCTCG GGCGGCCGCCCAGGCGAGGTGCGGCCTCCGCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGCTCTACACAAA GTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATAAAGTCCTCCT GCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTGACATACTTGT TGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATTCCAAACTTAT TTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATGCATACAGTGG TCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAAATCAGTCCAT CATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTTCTGCCAGTGA GGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATAATAGCAGCCG TTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGAAATCCAGAGT GGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAATGCTACGATT AGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGGCACATACTAG GCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAGGCAATGTTGG ATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTGTGGACTATGA GGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGGCCACAAATGC CCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTGCTGTCAAACA GCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATTATGCAAATGA AAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACACTCATAGATTT TTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGCCTAAAGGCAC AGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACAAAGCTTTCAT CATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAACAAATTAAAGT TCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCTCCTCAGGGCG CACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGGGGCATCAGTT CAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACTTCAAGTTCCC ATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCGGTTTCCCCTC ACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAACATGCAAGAA TGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGGCCTATCTAGA AAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGTACCTACGCAT GCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCAAGGCAGCAAC CATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGTCTTACTTGCG AGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCTGGCTGGCCCG CACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAAAGAAGCTCAA AATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAGTTGATGAGCA GAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAAGTGACTTAGA ACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCCGGAAAGACCT GGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAAATCTGAAGGA AGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGCATAGAAGATT AAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGGCAGCCGGAGT AGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGAC TCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAA AGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCA TCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTAC TTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGG CTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACG GATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCG GTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAAC TCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTG TCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCA GTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGA AGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGT ACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGA GAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTG TCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTA CTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTT >56714_56714_7_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399233_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_8_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399233_ROS1_chr6_117642557_ENST00000368508_length(transcript)=4999nt_BP=3404nt ACCCCGGGCAGGTGGAGCGCTCGCGGCTGCTCGCGGCGAGCCCGGGAGTGATGGCGAGGCCCCTGCGGGCGGCCAGCGCCTGAGGCGCCC CGCCCCGCCCCGCCCCGCGCGGCCCTCCCCGCCCGGCCCTGCCCTGCCCTGCTCCCTGCCGGCGGCTGCGGGCGCTTCCTAGTCCGCTCG GGCGGCCGCCCAGGCGAGGTGCGGCCTCCGCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGCTCTACACAAA GTTTGCCAGGGTTTGGATACCTGATCCAGAGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATAAAGTCCTCCT GCTTCACCTCGAGGAAGGAAAGGATTTGGAATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTGACATACTTGT TGGTGAAAATGACCTCACAGCCCTCAGCTATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATTCCAAACTTAT TTATACGTATTGTGGTATAGTCCTAGTAGCTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATGCATACAGTGG TCAGAACATGGGTGATATGGATCCACATATCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAAATCAGTCCAT CATCGTAAGTGGAGAGTCTGGGGCAGGAAAAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTTCTGCCAGTGA GGCCAATGTGGAGGAAAAGGTCTTGGCCTCCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATAATAGCAGCCG TTTTGGGAAGTATATTGAGATTGGTTTTGATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGAAATCCAGAGT GGTATTCCAGGCAGAAGAGGAGAGAAACTATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAATGCTACGATT AGGAAATGCAGATAACTTTAATTACACAAAACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGGCACATACTAG GCAGGCCTGCACTTTGCTAGGAATTAGTGAATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAGGCAATGTTGG ATTTACATCCCGAGATGCAGACAGCTGCACAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTGTGGACTATGA GGAGATGTGTCACTGGCTCTGCCATCGGAAACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGGCCACAAATGC CCGCGATGCTTTGGCCAAGCACATCTATGCCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTGCTGTCAAACA GCACTCTTTTATTGGTGTGCTAGACATTTACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATTATGCAAATGA AAAACTACAGCAACAATTCAATATGCATGTCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACACTCATAGATTT TTATGATAATCAGCCTTGTATTAATCTTATAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGCCTAAAGGCAC AGATGACACCTGGGCCCAAAAATTGTACAACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACAAAGCTTTCAT CATCCAACATTTTGCTGACAAAGTGGAATACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAACAAATTAAAGT TCTTAAATCAAGCAAGTTTAAGATGCTACCAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCTCCTCAGGGCG CACACCCCTCACACGAACTCCTGCAAAGCCCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGGGGCATCAGTT CAGAAACTCCCTGCACCTGCTTATGGAGACACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACTTCAAGTTCCC ATTCACGTTTGATGAGAAGAGGGCAGTGCAGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCGGTTTCCCCTC ACGGTGGACTTACCAAGAATTTTTCAGCCGCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAACATGCAAGAA TGTGTTAGAGAAACTGATACTGGACAAGGACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGGCCTATCTAGA AAAATTGAGAGCTGACAAACTGAGAGCTGCCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGTACCTACGCAT GCGGAAGGCAGCCATCACCATGCAGAGATACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCAAGGCAGCAAC CATCATTCAAAAGTACTGGCGCATGTATGTGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGTCTTACTTGCG AGGCTTCTTGGCCAGAAATAGGTATCGCAAGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCTGGCTGGCCCG CACACACTACAAGAGGAGCATGCATGCCATCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAAAGAAGCTCAA AATCGAGGCTCGCTCAGTGGAGCGCTATAAGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAGTTGATGAGCA GAACAAAGACTACAAATGCCTTGTGGAGAAACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAAGTGACTTAGA ACGTCTTCAACTAAGTGAAGAGGAAGCGAAAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCCGGAAAGACCT GGAGCAAACTCGTTCAGAGAAAAAATGCATTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAAATCTGAAGGA AGAAAATACTTTGCTGAAGCAAGAAAAAGAAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGCATAGAAGATT AAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGGCAGCCGGAGT AGGCCTGGCTAATGCCTGCTATGCAATACATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGAC TCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAA AGTAGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCA TCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTAC TTATTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGG CTGTGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACG GATAGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCG GTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAAC TCTTGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTG TCCTGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCA GTTATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGA AGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGT ACTTGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGA GAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTG TCTCACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTA CTGAAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTT >56714_56714_8_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000399233_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_9_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000553916_ROS1_chr6_117642557_ENST00000368507_length(transcript)=4790nt_BP=3195nt GCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGCTCTACACAAAGTTTGCCAGGGTTTGGATACCTGATCCAG AGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATAAAGTCCTCCTGCTTCACCTCGAGGAAGGAAAGGATTTGG AATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTGACATACTTGTTGGTGAAAATGACCTCACAGCCCTCAGCT ATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATTCCAAACTTATTTATACGTATTGTGGTATAGTCCTAGTAG CTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATGCATACAGTGGTCAGAACATGGGTGATATGGATCCACATA TCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAAATCAGTCCATCATCGTAAGTGGAGAGTCTGGGGCAGGAA AAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTTCTGCCAGTGAGGCCAATGTGGAGGAAAAGGTCTTGGCCT CCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATAATAGCAGCCGTTTTGGGAAGTATATTGAGATTGGTTTTG ATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGAAATCCAGAGTGGTATTCCAGGCAGAAGAGGAGAGAAACT ATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAATGCTACGATTAGGAAATGCAGATAACTTTAATTACACAA AACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGGCACATACTAGGCAGGCCTGCACTTTGCTAGGAATTAGTG AATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAGGCAATGTTGGATTTACATCCCGAGATGCAGACAGCTGCA CAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTGTGGACTATGAGGAGATGTGTCACTGGCTCTGCCATCGGA AACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGGCCACAAATGCCCGCGATGCTTTGGCCAAGCACATCTATG CCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTGCTGTCAAACAGCACTCTTTTATTGGTGTGCTAGACATTT ACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATTATGCAAATGAAAAACTACAGCAACAATTCAATATGCATG TCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACACTCATAGATTTTTATGATAATCAGCCTTGTATTAATCTTA TAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGCCTAAAGGCACAGATGACACCTGGGCCCAAAAATTGTACA ACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACAAAGCTTTCATCATCCAACATTTTGCTGACAAAGTGGAAT ACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAACAAATTAAAGTTCTTAAATCAAGCAAGTTTAAGATGCTAC CAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCTCCTCAGGGCGCACACCCCTCACACGAACTCCTGCAAAGC CCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGGGGCATCAGTTCAGAAACTCCCTGCACCTGCTTATGGAGA CACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACTTCAAGTTCCCATTCACGTTTGATGAGAAGAGGGCAGTGC AGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCGGTTTCCCCTCACGGTGGACTTACCAAGAATTTTTCAGCC GCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAACATGCAAGAATGTGTTAGAGAAACTGATACTGGACAAGG ACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGGCCTATCTAGAAAAATTGAGAGCTGACAAACTGAGAGCTG CCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGTACCTACGCATGCGGAAGGCAGCCATCACCATGCAGAGAT ACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCAAGGCAGCAACCATCATTCAAAAGTACTGGCGCATGTATG TGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGTCTTACTTGCGAGGCTTCTTGGCCAGAAATAGGTATCGCA AGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCTGGCTGGCCCGCACACACTACAAGAGGAGCATGCATGCCA TCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAAAGAAGCTCAAAATCGAGGCTCGCTCAGTGGAGCGCTATA AGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAGTTGATGAGCAGAACAAAGACTACAAATGCCTTGTGGAGA AACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAAGTGACTTAGAACGTCTTCAACTAAGTGAAGAGGAAGCGA AAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCCGGAAAGACCTGGAGCAAACTCGTTCAGAGAAAAAATGCA TTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAAATCTGAAGGAAGAAAATACTTTGCTGAAGCAAGAAAAAG AAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGG TGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGGCAGCCGGAGTAGGCCTGGCTAATGCCTGCTATGCAATAC ATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCTGCGTCTCTTGCTGGGAAGTGGAGCCT TTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAAAGTAGCAGTGAAGACTTTGAAGAAGGGTT CCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCATCCCAACATTCTGAAGCAGCTTGGAGTTT GTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTACTTATTTGCGTAAAGCCCGGATGGCAACGT TTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGGCTGTGTCTACTTGGAACGGATGCATTTCA TTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACGGATAGTGAAGATTGGAGACTTTGGACTCG CCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCGGTGGATGGCTCCAGAAAGTTTGATGGATG GAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATT CCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTGTCCTGATGATCTGTGGAATTTAATGACCC AGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCAGTTATTCAGAAATTTTTTCTTAAATAGCA TTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGAAGATGGCGATGTGATTTGTTTGAATTCAG ATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGTACTTGCTACAGAATGTGGCCAAGGTGAAG AAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGAGAAGGAACCACATGCAGACAAAGATTTCT GCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTGTCTCACTCACAGTGGATATGGAGATGGGT CTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTACTGAAAGAAAACTCTGCTAGAATGATAAA TGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTTCTGAGAGCCATTTGGTTTCAGTTGTAGCA >56714_56714_9_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000553916_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- >56714_56714_10_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000553916_ROS1_chr6_117642557_ENST00000368508_length(transcript)=4790nt_BP=3195nt GCACAGGCGGGGGGCGTAGGCGCGCGGGGCCCGCCATGGCTGCGTCGGAGCTCTACACAAAGTTTGCCAGGGTTTGGATACCTGATCCAG AGGAAGTCTGGAAGTCAGCAGAGCTGCTCAAAGATTATAAGCCAGGAGATAAAGTCCTCCTGCTTCACCTCGAGGAAGGAAAGGATTTGG AATACCATCTAGATCCAAAGACCAAGGAGCTGCCTCACTTACGAAATCCTGACATACTTGTTGGTGAAAATGACCTCACAGCCCTCAGCT ATCTTCATGAGCCTGCTGTGCTCCATAATCTCAGAGTCCGCTTTATTGATTCCAAACTTATTTATACGTATTGTGGTATAGTCCTAGTAG CTATAAATCCCTATGAACAGCTGCCTATTTATGGAGAAGATATTATTAATGCATACAGTGGTCAGAACATGGGTGATATGGATCCACATA TCTTTGCAGTAGCTGAAGAAGCTTACAAGCAAATGGCCAGAGATGAACGAAATCAGTCCATCATCGTAAGTGGAGAGTCTGGGGCAGGAA AAACAGTCTCAGCTAAGTATGCCATGCGATACTTTGCAACTGTGAGTGGTTCTGCCAGTGAGGCCAATGTGGAGGAAAAGGTCTTGGCCT CCAACCCCATCATGGAGTCCATTGGAAATGCTAAAACAACCAGGAATGATAATAGCAGCCGTTTTGGGAAGTATATTGAGATTGGTTTTG ATAAGAGATATCGAATCATTGGTGCCAATATGAGAACTTATCTTTTAGAGAAATCCAGAGTGGTATTCCAGGCAGAAGAGGAGAGAAACT ATCATATCTTCTATCAGCTTTGTGCCTCAGCAAAGTTACCTGAATTTAAAATGCTACGATTAGGAAATGCAGATAACTTTAATTACACAA AACAAGGAGGCAGTCCTGTGATTGAAGGAGTGGATGATGCAAAGGAGATGGCACATACTAGGCAGGCCTGCACTTTGCTAGGAATTAGTG AATCTCATCAAATGGGAATTTTCCGAATACTTGCTGGCATCCTTCACTTAGGCAATGTTGGATTTACATCCCGAGATGCAGACAGCTGCA CAATACCTCCCAAGCATGAACCTCTCTGCATCTTCTGTGAACTCATGGGTGTGGACTATGAGGAGATGTGTCACTGGCTCTGCCATCGGA AACTGGCTACTGCCACAGAGACATACATCAAGCCCATCTCCAAGCTGCAGGCCACAAATGCCCGCGATGCTTTGGCCAAGCACATCTATG CCAAGCTCTTTAACTGGATTGTAGATAATGTCAATCAGGCTCTCCATTCTGCTGTCAAACAGCACTCTTTTATTGGTGTGCTAGACATTT ACGGATTTGAAACATTTGAGATAAATAGTTTTGAACAGTTTTGCATAAATTATGCAAATGAAAAACTACAGCAACAATTCAATATGCATG TCTTCAAATTGGAGCAAGAAGAATATATGAAGGAACAAATTCCATGGACACTCATAGATTTTTATGATAATCAGCCTTGTATTAATCTTA TAGAATCAAAACTAGGCATTCTAGATTTACTGGATGAGGAATGCAAGATGCCTAAAGGCACAGATGACACCTGGGCCCAAAAATTGTACA ACACACATTTGAACAAATGTGCACTCTTTGAAAAGCCTCGTCTATCAAACAAAGCTTTCATCATCCAACATTTTGCTGACAAAGTGGAAT ACCAGTGTGAAGGATTTCTCGAAAAGAATAAAGACACCGTTTTTGAAGAACAAATTAAAGTTCTTAAATCAAGCAAGTTTAAGATGCTAC CAGAACTATTTCAAGATGATGAGAAGGCCATCAGTCCAACTTCAGCCACCTCCTCAGGGCGCACACCCCTCACACGAACTCCTGCAAAGC CCACCAAAGGCAGACCAGGCCAAATGGCCAAAGAGCACAAGAAAACAGTGGGGCATCAGTTCAGAAACTCCCTGCACCTGCTTATGGAGA CACTCAATGCCACTACCCCTCACTATGTGCGCTGTATCAAGCCTAATGACTTCAAGTTCCCATTCACGTTTGATGAGAAGAGGGCAGTGC AGCAGCTGAGAGCATGTGGTGTCCTGGAAACCATCCGAATCAGTGCGGCCGGTTTCCCCTCACGGTGGACTTACCAAGAATTTTTCAGCC GCTACCGTGTCCTAATGAAGCAGAAAGATGTGCTGAGTGACAGAAAGCAAACATGCAAGAATGTGTTAGAGAAACTGATACTGGACAAGG ACAAATACCAGTTTGGTAAGACAAAGATCTTTTTCCGTGCCGGTCAAGTGGCCTATCTAGAAAAATTGAGAGCTGACAAACTGAGAGCTG CCTGCATCCGGATCCAGAAGACCATCCGAGGGTGGCTGCTGAGAAAGAAGTACCTACGCATGCGGAAGGCAGCCATCACCATGCAGAGAT ACGTGCGGGGCTACCAGGCCCGATGCTATGCTAAGTTTCTGCGCAGAACCAAGGCAGCAACCATCATTCAAAAGTACTGGCGCATGTATG TGGTCCGCAGGAGGTACAAGATTAGACGAGCTGCCACTATCGTTCTTCAGTCTTACTTGCGAGGCTTCTTGGCCAGAAATAGGTATCGCA AGATACTCCGTGAGCACAAAGCAGTCATCATTCAGAAGCGAGTCCGGGGCTGGCTGGCCCGCACACACTACAAGAGGAGCATGCATGCCA TCATCTACCTTCAGTGCTGCTTCAGGCGGATGATGGCCAAGCGTGAGCTAAAGAAGCTCAAAATCGAGGCTCGCTCAGTGGAGCGCTATA AGAAGCTGCACATCGGCATGGAGAACAAGATCATGCAGCTGCAGCGCAAAGTTGATGAGCAGAACAAAGACTACAAATGCCTTGTGGAGA AACTAACCAATCTGGAAGGAATATACAACTCTGAGACTGAGAAACTACGAAGTGACTTAGAACGTCTTCAACTAAGTGAAGAGGAAGCGA AAGTTGCCACTGGGCGGGTCCTTAGTCTGCAGGAAGAAATTGCCAAGCTCCGGAAAGACCTGGAGCAAACTCGTTCAGAGAAAAAATGCA TTGAGGAACATGCAGATCGATACAAACAAGAAACAGAGCAGCTGGTATCAAATCTGAAGGAAGAAAATACTTTGCTGAAGCAAGAAAAAG AAGCCCTCAATCACCGCATCGTGCAGCAGGCTAAGGAGATGACAGTCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGG TGACAGTGCTTATAAACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGGCAGCCGGAGTAGGCCTGGCTAATGCCTGCTATGCAATAC ATACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCTGCGTCTCTTGCTGGGAAGTGGAGCCT TTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAAAGTAGCAGTGAAGACTTTGAAGAAGGGTT CCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCATCCCAACATTCTGAAGCAGCTTGGAGTTT GTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTACTTATTTGCGTAAAGCCCGGATGGCAACGT TTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGGCTGTGTCTACTTGGAACGGATGCATTTCA TTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACGGATAGTGAAGATTGGAGACTTTGGACTCG CCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCGGTGGATGGCTCCAGAAAGTTTGATGGATG GAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAACTCTTGGTCATCAGCCTTATCCAGCTCATT CCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTGTCCTGATGATCTGTGGAATTTAATGACCC AGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCAGTTATTCAGAAATTTTTTCTTAAATAGCA TTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGAAGATGGCGATGTGATTTGTTTGAATTCAG ATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGTACTTGCTACAGAATGTGGCCAAGGTGAAG AAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGAGAAGGAACCACATGCAGACAAAGATTTCT GCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTGTCTCACTCACAGTGGATATGGAGATGGGT CTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTACTGAAAGAAAACTCTGCTAGAATGATAAA TGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTTCTGAGAGCCATTTGGTTTCAGTTGTAGCA >56714_56714_10_MYO5A-ROS1_MYO5A_chr15_52659227_ENST00000553916_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=1520AA_BP=1053 MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLR VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAK LPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHEPLCIF CELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEK PRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKE HKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL SDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAK FLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMM AKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQE EIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTVWHRRLKNQKSAKEGVTVLINEDKELA ELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLV SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MYO5A-ROS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MYO5A-ROS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MYO5A-ROS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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