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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO5B-CLUL1 (FusionGDB2 ID:56720)

Fusion Gene Summary for MYO5B-CLUL1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO5B-CLUL1
Fusion gene ID: 56720
HgeneTgene
Gene symbol

MYO5B

CLUL1

Gene ID

4645

27098

Gene namemyosin VBclusterin like 1
Synonyms-RA337M
Cytomap

18q21.1

18p11.32

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-VbMYO5B variant proteinmyosin-Vbclusterin-like protein 1clusterin-like 1 (retinal)retinal clusterin-like proteinretinal-specific clusterin-like protein
Modification date2020031320200313
UniProtAcc

Q9ULV0

Q15846

Ensembl transtripts involved in fusion geneENST00000285039, ENST00000324581, 
ENST00000587895, ENST00000592688, 
ENST00000580436, ENST00000338387, 
ENST00000400606, ENST00000540035, 
ENST00000579494, ENST00000581619, 
Fusion gene scores* DoF score18 X 15 X 7=18904 X 4 X 3=48
# samples 215
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYO5B [Title/Abstract] AND CLUL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO5B(47721137)-CLUL1(617988), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYO5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLUL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1R6-01AMYO5Bchr18

47721137

-CLUL1chr18

606978

+
ChimerDB4BRCATCGA-E9-A1R6-01AMYO5Bchr18

47721137

-CLUL1chr18

617988

+


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Fusion Gene ORF analysis for MYO5B-CLUL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000285039ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

617988

+
5CDS-5UTRENST00000285039ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

617988

+
5CDS-5UTRENST00000285039ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

617988

+
5CDS-5UTRENST00000285039ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

606978

+
5CDS-5UTRENST00000285039ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

617988

+
5CDS-5UTRENST00000285039ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

617988

+
5CDS-5UTRENST00000285039ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

617988

+
5CDS-intronENST00000285039ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

606978

+
5CDS-intronENST00000285039ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

606978

+
5CDS-intronENST00000285039ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

606978

+
5CDS-intronENST00000285039ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

606978

+
5CDS-intronENST00000285039ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-3UTRENST00000324581ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-3UTRENST00000587895ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-3UTRENST00000592688ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000324581ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000324581ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000324581ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-5UTRENST00000324581ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000324581ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000324581ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000587895ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000587895ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000587895ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-5UTRENST00000587895ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000587895ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000587895ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000592688ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000592688ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000592688ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-5UTRENST00000592688ENST00000540035MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000592688ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-5UTRENST00000592688ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

617988

+
intron-intronENST00000324581ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000324581ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000324581ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000324581ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000324581ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000587895ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000587895ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000587895ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000587895ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000587895ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000592688ENST00000338387MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000592688ENST00000400606MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000592688ENST00000579494MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000592688ENST00000580436MYO5Bchr18

47721137

-CLUL1chr18

606978

+
intron-intronENST00000592688ENST00000581619MYO5Bchr18

47721137

-CLUL1chr18

606978

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MYO5B-CLUL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYO5B-CLUL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47721137/:617988)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO5B

Q9ULV0

CLUL1

Q15846

FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MYO5B-CLUL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYO5B-CLUL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO5B-CLUL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO5B-CLUL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource