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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO5B-MBD2 (FusionGDB2 ID:56731)

Fusion Gene Summary for MYO5B-MBD2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO5B-MBD2
Fusion gene ID: 56731
HgeneTgene
Gene symbol

MYO5B

MBD2

Gene ID

4645

64174

Gene namemyosin VBdipeptidase 2
Synonyms-MBD2
Cytomap

18q21.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-VbMYO5B variant proteinmyosin-Vbdipeptidase 2
Modification date2020031320200313
UniProtAcc

Q9ULV0

Q9UBB5

Ensembl transtripts involved in fusion geneENST00000285039, ENST00000324581, 
ENST00000587895, ENST00000592688, 
ENST00000398398, ENST00000579025, 
ENST00000583046, ENST00000256429, 
Fusion gene scores* DoF score18 X 15 X 7=189013 X 7 X 7=637
# samples 2115
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/637*10)=-2.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO5B [Title/Abstract] AND MBD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO5B(47398537)-MBD2(51715381), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYO5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MBD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7722-01AMYO5Bchr18

47398537

-MBD2chr18

51715381

-


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Fusion Gene ORF analysis for MYO5B-MBD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000285039ENST00000398398MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5CDS-intronENST00000285039ENST00000579025MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5CDS-intronENST00000285039ENST00000583046MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5CDS-intronENST00000324581ENST00000398398MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5CDS-intronENST00000324581ENST00000579025MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5CDS-intronENST00000324581ENST00000583046MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5UTR-3CDSENST00000587895ENST00000256429MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5UTR-intronENST00000587895ENST00000398398MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5UTR-intronENST00000587895ENST00000579025MYO5Bchr18

47398537

-MBD2chr18

51715381

-
5UTR-intronENST00000587895ENST00000583046MYO5Bchr18

47398537

-MBD2chr18

51715381

-
In-frameENST00000285039ENST00000256429MYO5Bchr18

47398537

-MBD2chr18

51715381

-
In-frameENST00000324581ENST00000256429MYO5Bchr18

47398537

-MBD2chr18

51715381

-
intron-3CDSENST00000592688ENST00000256429MYO5Bchr18

47398537

-MBD2chr18

51715381

-
intron-intronENST00000592688ENST00000398398MYO5Bchr18

47398537

-MBD2chr18

51715381

-
intron-intronENST00000592688ENST00000579025MYO5Bchr18

47398537

-MBD2chr18

51715381

-
intron-intronENST00000592688ENST00000583046MYO5Bchr18

47398537

-MBD2chr18

51715381

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285039MYO5Bchr1847398537-ENST00000256429MBD2chr1851715381-7052390330044361378
ENST00000324581MYO5Bchr1847398537-ENST00000256429MBD2chr1851715381-4183103481567519

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285039ENST00000256429MYO5Bchr1847398537-MBD2chr1851715381-0.0019526670.99804735
ENST00000324581ENST00000256429MYO5Bchr1847398537-MBD2chr1851715381-0.0031285230.99687153

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Fusion Genomic Features for MYO5B-MBD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO5B-MBD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:47398537/chr18:51715381)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO5B

Q9ULV0

MBD2

Q9UBB5

FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656}.FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740801_91612011849.0Compositional biasNote=Arg-rich
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-274069_76112011849.0DomainMyosin motor
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740769_79812011849.0DomainIQ 1
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740792_82112011849.0DomainIQ 2
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740817_84812011849.0DomainIQ 3
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740840_86912011849.0DomainIQ 4
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740865_89612011849.0DomainIQ 5
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740888_91712011849.0DomainIQ 6
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-27408_6012011849.0DomainMyosin N-terminal SH3-like
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740163_17012011849.0Nucleotide bindingATP
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740640_66212011849.0RegionActin-binding
TgeneMBD2chr18:47398537chr18:51715381ENST000005830460350_960303.0Compositional biasNote=Arg-rich
TgeneMBD2chr18:47398537chr18:51715381ENST00000583046036_1400303.0Compositional biasNote=Gly-rich
TgeneMBD2chr18:47398537chr18:51715381ENST0000058304603145_2130303.0DomainMBD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-27401341_147112011849.0Coiled coilOntology_term=ECO:0000255
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-2740899_126612011849.0Coiled coilOntology_term=ECO:0000255
HgeneMYO5Bchr18:47398537chr18:51715381ENST00000285039-27401526_180312011849.0DomainDilute
TgeneMBD2chr18:47398537chr18:51715381ENST000002564291750_962341015.6666666666666Compositional biasNote=Arg-rich
TgeneMBD2chr18:47398537chr18:51715381ENST00000256429176_1402341015.6666666666666Compositional biasNote=Gly-rich
TgeneMBD2chr18:47398537chr18:51715381ENST0000025642917145_2132341015.6666666666666DomainMBD


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Fusion Gene Sequence for MYO5B-MBD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56731_56731_1_MYO5B-MBD2_MYO5B_chr18_47398537_ENST00000285039_MBD2_chr18_51715381_ENST00000256429_length(transcript)=7052nt_BP=3903nt
TCGCCGGCCCTCGCCTCCTCCCCACACCTGGGAGGGGAGTGGTGCGGCGCGGCCTCCTCCCCCGGCGCTCGCAACTCCTGTCCGGCCGTA
GCTGCGCCGCCGCGGCGGGAGTAAAGGTCGCGCCGCCGGGAGCGAGCCGGCCGCGGCGCCTGCGGGAAGCCGGCGGGGCAGGTCGGAGAA
GAGCGAGAAGATCGAGAAACTCCAGGCCAGCCCGGGAACATGGCGCCAGGCGGGCCAGCCGCGGACTGAGAGCCGCGGGGCAGCCAGGAG
CCGGGGCCCGAGCCCCGCCCGGCCCGGGCCATGTCGGTGGGCGAGCTCTACAGCCAGTGCACAAGGGTCTGGATCCCTGACCCTGATGAG
GTATGGCGCTCAGCTGAGTTAACCAAGGACTACAAAGAAGGAGACAAGAGCCTACAGCTCAGACTGGAGGATGAAACGATTCTGGAATAC
CCAATTGATGTACAACGCAACCAGCTGCCCTTCTTACGGAATCCAGATATCTTGGTGGGAGAAAATGACCTGACTGCCCTTAGCTATCTT
CATGAGCCTGCAGTTTTGCATAATTTGAAGGTCCGTTTCCTGGAGTCCAACCATATCTACACTTACTGTGGTATCGTACTTGTTGCCATT
AATCCTTATGAACAGTTGCCAATCTATGGACAAGATGTCATCTATACCTACAGTGGCCAAAACATGGGAGACATGGACCCCCACATCTTT
GCTGTGGCAGAAGAAGCCTACAAGCAGATGGCCAGAGATGAGAAGAATCAGTCCATCATAGTCAGTGGGGAGTCTGGAGCCGGGAAGACG
GTATCAGCCAAGTATGCCATGCGCTATTTCGCCACCGTTGGTGGCTCGGCCAGTGAAACCAACATCGAAGAGAAGGTGCTGGCATCCAGT
CCCATCATGGAGGCCATTGGAAATGCCAAGACCACCCGCAATGACAACAGCAGCCGTTTTGGCAAGTACATCCAGATTGGCTTTGACAAA
AGGTACCACATCATCGGGGCCAACATGAGGACTTACCTCTTGGAGAAGTCCAGAGTGGTCTTCCAGGCAGATGATGAGAGGAATTACCAC
ATCTTTTACCAGCTCTGTGCTGCTGCCGGTCTTCCAGAATTTAAAGAGCTTGCACTAACAAGTGCAGAGGACTTTTTCTATACATCACAG
GGAGGAGACACTTCCATCGAGGGTGTGGACGATGCTGAGGACTTTGAGAAGACTCGACAAGCCTTCACACTCCTCGGAGTGAAAGAGTCC
CATCAGATGAGCATTTTTAAGATAATTGCTTCTATCTTGCACCTTGGAAGTGTGGCGATTCAGGCTGAGCGTGATGGTGATTCCTGTAGT
ATATCACCCCAGGATGTATACCTAAGCAACTTCTGCCGACTGCTAGGGGTGGAGCACAGTCAGATGGAGCACTGGCTGTGTCATCGCAAG
CTGGTCACCACCTCGGAGACCTACGTCAAGACCATGTCCCTGCAGCAGGTGATCAATGCGCGCAACGCCCTGGCGAAGCACATCTATGCC
CAGTTGTTCGGCTGGATTGTGGAGCACATCAACAAGGCCCTGCACACCTCCCTCAAGCAGCACTCCTTCATCGGGGTCCTGGACATCTAT
GGGTTTGAGACATTTGAGGTAAACAGCTTTGAGCAGTTCTGTATCAACTATGCAAATGAAAAGCTCCAGCAGCAGTTCAACTCGCATGTT
TTCAAACTGGAGCAAGAAGAATACATGAAGGAACAGATCCCTTGGACCCTGATTGATTTTTATGATAACCAACCTTGTATCGACCTCATT
GAAGCCAAGCTGGGTATCTTGGACCTGTTGGATGAAGAATGTAAGGTCCCCAAAGGAACTGACCAGAACTGGGCTCAGAAGCTCTATGAC
CGGCACTCCAGCAGCCAGCACTTCCAGAAGCCCCGCATGTCCAACACGGCCTTCATCATCGTCCACTTTGCAGACAAGGTGGAGTACCTC
TCTGATGGTTTTCTGGAGAAAAACAGAGACACGGTGTATGAAGAGCAGATCAATATCCTGAAGGCCAGCAAGTTCCCACTAGTGGCTGAC
TTGTTTCATGATGACAAGGACCCTGTTCCTGCCACCACCCCTGGGAAGGGGTCATCTTCGAAGATCAGCGTCCGTTCTGCCAGACCCCCC
ATGAAAGTCTCCAACAAGGAGCACAAGAAAACCGTTGGCCACCAGTTCCGTACCTCCCTGCATCTGCTCATGGAGACCCTGAATGCCACG
ACACCTCACTATGTCCGCTGCATCAAGCCCAACGATGAGAAGCTCCCCTTTCACTTTGACCCAAAGAGAGCAGTGCAGCAACTCAGAGCC
TGCGGGGTGTTGGAGACGATTCGAATCAGTGCAGCTGGCTACCCATCCAGGTGGGCCTACCATGACTTTTTCAACCGGTATCGGGTGCTG
GTCAAGAAGAGAGAGCTCGCCAACACAGACAAAAAGGCCATCTGCAGGTCTGTCCTGGAGAACCTCATCAAGGACCCCGACAAGTTCCAG
TTTGGCCGCACCAAGATCTTCTTTCGAGCAGGCCAGGTGGCCTACCTGGAGAAGCTGCGGGCTGACAAGTTCCGGACAGCCACCATCATG
ATCCAGAAAACTGTCCGGGGATGGCTGCAGAAGGTGAAATATCACAGGCTGAAGGGGGCTACCTTAACCCTGCAGAGGTACTGCCGGGGA
CACCTGGCCCGCAGGCTGGCTGAGCACCTGCGGAGGATCAGAGCGGCTGTGGTGCTCCAGAAACATTACCGCATGCAGAGGGCCCGCCAG
GCCTACCAGAGGGTCCGCAGAGCTGCCGTTGTTATCCAGGCCTTCACCCGGGCCATGTTTGTGCGGAGAACCTACCGCCAGGTCCTCATG
GAGCACAAGGCCACCACCATCCAGAAGCACGTGCGGGGCTGGATGGCACGCAGGCACTTCCAGCGGCTGCGGGATGCAGCCATTGTCATC
CAGTGTGCCTTCCGGATGCTCAAGGCCAGGCGGGAGCTGAAGGCCCTCAGGATTGAGGCCCGCTCAGCAGAGCATCTGAAACGTCTCAAC
GTGGGCATGGAGAACAAGGTGGTCCAGCTGCAGCGGAAGATCGATGAGCAGAACAAAGAGTTCAAGACACTTTCAGAGCAGTTGTCCGTG
ACCACCTCAACATACACCATGGAGGTAGAGCGGCTGAAGAAGGAGCTGGTGCACTACCAGCAGAGCCCAGGTGAGGACACCAGCCTCAGG
CTGCAGGAGGAGGTGGAGAGCCTGCGCACAGAGCTGCAGAGGGCCCACTCGGAGCGCAAGATCTTGGAGGACGCCCACAGCAGGGAGAAA
GATGAGCTGAGGAAGCGAGTTGCAGACCTGGAGCAAGAAAATGCTCTCTTGAAAGATGAGAAAGAACAGCTCAACAACCAAATCCTGTGC
CAGTCTAAAGATGAATTTGCCCAGAACTCTGTGAAGGAAAATCTCATGAAGAAAGAACTGGAGGAGGAGCGATCCCGGTACCAGAACCTT
GTGAAGGAATATTCACAGTTGGAGCAGAGATACGACAACCTTCGGGATGAAATGACCATCATAAAGCAAACTCCAGGTCATAGGCGGAAC
CCATCAAACCAAAGTAGCTTAGAATCTGACTCCAATTACCCCTCCATCTCCACATCTGAGATCGGAGACACTGAGGATGCCCTCCAGCAG
GTGGAGGAAATTGGCCTGGAGAAGGCAGCCATGGACATGACGGTCTTCCTGAAGCTGCAGAAGAGAGTACGGGAGCTGGAGCAGGAGAGG
AAAAAGCTGCAAGTGCAGCTGGAGAAGAGAGAACAGCAGGACAGCAAGAAAGTCCAGGCGGAACCACCACAGACTGACATAGATTTGGAC
CCGAATGCAGATCTGGCCTACAATAGTCTGAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAA
CAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAGCTTTTCTGG
GAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATAAAAACCATGGAACTACCCAAAGGTCTTCAAGGAGTTGGT
CCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGCGCCAATCACAGGGCAAGTCTCCGCTGCT
GTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAAGCTTTTATTGTCACAGATGAAGACATCAGGAAACAGGAA
GAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCGAGCTGCTGATACAGAAGAGATGGATATT
GAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGACCGACTTTCCCCAAGAGAAAATTCCTAGAAATTGAACAAA
AATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACATAGAGCTTTTTAATAGCACTAACCAATGCCTTTTTAGATG
TATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTCCTAGGACTTAAAATTAGTCTTTTGTAATATCAAGCAGGA
CCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGTAGCACTTACGTAAAACATTTGTTTCCCCCACAGTTTTAA
TAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTGACTTCACTGTATATAAACATATTTTTATACTTTATTGAA
AGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGATTATATTCACAGACTGATTGGAATTCTTTCTGTTGAAAAG
CACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACTCTGATCCCTGGGCCTTAGGTTTGACATGGAGGTGGAGGA
AGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGAATTGTGCTTTCACCAGAATTTCTAAGAATTTCTGCTAAA
TATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTGATAGTTCTATAAGAATAAGGCTTTTTCTTCCCTTGGGCA
TGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTTTATTGTTTTTTAAAGAATGTTTGGCACTCTCTAACGTCC
ACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGAGGCAGCTTCTAGACAGAGTTGCTTAATGAAAGGGTTTGT
AATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAACATTCTTTTTCTGTTGAAACTCGCGAGTGTAACTTTCATA
CCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAAACGATTTCTAAAATCAAAACATACTTAATCTGATACCAA
GGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGAGCAAAAGTAAAATCATTCTATAGAAAAGGTGTGTTTATT
TCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGGGTATGACCAATTCCACATGAGTGTCACCTGTACATTTTA
TTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAGCAATATGACTAGCTAGGTTTGGGCTGCTGTTTGGGCTG
CTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTCCTGATTTACGCTCAACTTTGATCCCTGGACCCTAGGGCC
ATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAGACCCTGGGAAGCCAATTGGTAGAGGGTGCCTGCCCGCCC
CATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTTTAAAAGCTAGTATGACTAGTGAGAATGGATGTCCAAGGG
CTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTGGGGTAACTTCACCTTGGTGATCATATATTCTTTTTACAA
ACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAAACACAATGTATACACATATAAAACTGATTTTTTTTTTT
TTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATATGGTGTCCCTTGGGGACCATCCCATAAGTCCAGGGTGTTC
CCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCACAAACCTACCACCCTCTTCCATTCCCTCACTCTGGTAAAA
GCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAATGCTGCCCTTTCCCTTGCTTCTGACTTCTCATCAATCCT
ATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGCCTTCATATGAACTGCCTTTCCTGTCCTCTGGACTTTCAG
TGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCATCCCTCCACATAGTCATCAGAAAGATCATCAAAACAGGC
AAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTGATTTTTAAGAGCACACACTTTGAAATTAGGAGAACCTGT
GTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCTCTTTGAGCCTGTCCCTCCTCAGTGAAATAGGAATAATAA
TACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTAAAGTGTGTAGCACAGTGCCTGGCACATAGTGGGTGCTCA

>56731_56731_1_MYO5B-MBD2_MYO5B_chr18_47398537_ENST00000285039_MBD2_chr18_51715381_ENST00000256429_length(amino acids)=1378AA_BP=1201
MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLK
VRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYF
ATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAG
LPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSN
FCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSF
EQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQK
PRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKK
TVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTD
KKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHL
RRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKAR
RELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRT
ELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQR
YDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKR
EQQDSKKVQAEPPQTDIDLDPNADLAYNSLKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSAS
DVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKL

--------------------------------------------------------------
>56731_56731_2_MYO5B-MBD2_MYO5B_chr18_47398537_ENST00000324581_MBD2_chr18_51715381_ENST00000256429_length(transcript)=4183nt_BP=1034nt
AGGTCCTCATGGAGCACAAGGCCACCACCATCCAGAAGCACGTGCGGGGCTGGATGGCACGCAGGCACTTCCAGCGGCTGCGGGATGCAG
CCATTGTCATCCAGTGTGCCTTCCGGATGCTCAAGGCCAGGCGGGAGCTGAAGGCCCTCAGGATTGAGGCCCGCTCAGCAGAGCATCTGA
AACGTCTCAACGTGGGCATGGAGAACAAGGTGGTCCAGCTGCAGCGGAAGATCGATGAGCAGAACAAAGAGTTCAAGACACTTTCAGAGC
AGTTGTCCGTGACCACCTCAACATACACCATGGAGGTAGAGCGGCTGAAGAAGGAGCTGGTGCACTACCAGCAGAGCCCAGGTGAGGACA
CCAGCCTCAGGCTGCAGGAGGAGGTGGAGAGCCTGCGCACAGAGCTGCAGAGGGCCCACTCGGAGCGCAAGATCTTGGAGGACGCCCACA
GCAGGGAGAAAGATGAGCTGAGGAAGCGAGTTGCAGACCTGGAGCAAGAAAATGCTCTCTTGAAAGATGAGAAAGAACAGCTCAACAACC
AAATCCTGTGCCAGTCTAAAGATGAATTTGCCCAGAACTCTGTGAAGGAAAATCTCATGAAGAAAGAACTGGAGGAGGAGCGATCCCGGT
ACCAGAACCTTGTGAAGGAATATTCACAGTTGGAGCAGAGATACGACAACCTTCGGGATGAAATGACCATCATAAAGCAAACTCCAGGTC
ATAGGCGGAACCCATCAAACCAAAGTAGCTTAGAATCTGACTCCAATTACCCCTCCATCTCCACATCTGAGATCGGAGACACTGAGGATG
CCCTCCAGCAGGTGGAGGAAATTGGCCTGGAGAAGGCAGCCATGGACATGACGGTCTTCCTGAAGCTGCAGAAGAGAGTACGGGAGCTGG
AGCAGGAGAGGAAAAAGCTGCAAGTGCAGCTGGAGAAGAGAGAACAGCAGGACAGCAAGAAAGTCCAGGCGGAACCACCACAGACTGACA
TAGATTTGGACCCGAATGCAGATCTGGCCTACAATAGTCTGAAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACAGCAT
CAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTC
AGCTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATAAAAACCATGGAACTACCCAAAGGTCTTC
AAGGAGTTGGTCCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGCGCCAATCACAGGGCAAG
TCTCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAAGCTTTTATTGTCACAGATGAAGACATCA
GGAAACAGGAAGAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCGAGCTGCTGATACAGAAG
AGATGGATATTGAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGACCGACTTTCCCCAAGAGAAAATTCCTAGA
AATTGAACAAAAATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACATAGAGCTTTTTAATAGCACTAACCAATGC
CTTTTTAGATGTATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTCCTAGGACTTAAAATTAGTCTTTTGTAAT
ATCAAGCAGGACCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGTAGCACTTACGTAAAACATTTGTTTCCCC
CACAGTTTTAATAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTGACTTCACTGTATATAAACATATTTTTAT
ACTTTATTGAAAGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGATTATATTCACAGACTGATTGGAATTCTTT
CTGTTGAAAAGCACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACTCTGATCCCTGGGCCTTAGGTTTGACATG
GAGGTGGAGGAAGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGAATTGTGCTTTCACCAGAATTTCTAAGAA
TTTCTGCTAAATATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTGATAGTTCTATAAGAATAAGGCTTTTTCT
TCCCTTGGGCATGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTTTATTGTTTTTTAAAGAATGTTTGGCACT
CTCTAACGTCCACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGAGGCAGCTTCTAGACAGAGTTGCTTAATG
AAAGGGTTTGTAATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAACATTCTTTTTCTGTTGAAACTCGCGAGTG
TAACTTTCATACCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAAACGATTTCTAAAATCAAAACATACTTAA
TCTGATACCAAGGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGAGCAAAAGTAAAATCATTCTATAGAAAAG
GTGTGTTTATTTCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGGGTATGACCAATTCCACATGAGTGTCACC
TGTACATTTTATTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAGCAATATGACTAGCTAGGTTTGGGCTGC
TGTTTGGGCTGCTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTCCTGATTTACGCTCAACTTTGATCCCTGG
ACCCTAGGGCCATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAGACCCTGGGAAGCCAATTGGTAGAGGGTG
CCTGCCCGCCCCATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTTTAAAAGCTAGTATGACTAGTGAGAATGG
ATGTCCAAGGGCTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTGGGGTAACTTCACCTTGGTGATCATATAT
TCTTTTTACAAACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAAACACAATGTATACACATATAAAACTGA
TTTTTTTTTTTTTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATATGGTGTCCCTTGGGGACCATCCCATAAGT
CCAGGGTGTTCCCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCACAAACCTACCACCCTCTTCCATTCCCTCA
CTCTGGTAAAAGCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAATGCTGCCCTTTCCCTTGCTTCTGACTTC
TCATCAATCCTATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGCCTTCATATGAACTGCCTTTCCTGTCCTC
TGGACTTTCAGTGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCATCCCTCCACATAGTCATCAGAAAGATCA
TCAAAACAGGCAAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTGATTTTTAAGAGCACACACTTTGAAATTA
GGAGAACCTGTGTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCTCTTTGAGCCTGTCCCTCCTCAGTGAAAT
AGGAATAATAATACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTAAAGTGTGTAGCACAGTGCCTGGCACATA

>56731_56731_2_MYO5B-MBD2_MYO5B_chr18_47398537_ENST00000324581_MBD2_chr18_51715381_ENST00000256429_length(amino acids)=519AA_BP=342
MEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLS
VTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQIL
CQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQ
QVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKGKPDLNTTLPIRQTASIF
KQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSA

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Fusion Gene PPI Analysis for MYO5B-MBD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO5B-MBD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO5B-MBD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource