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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO6-SENP6 (FusionGDB2 ID:56756)

Fusion Gene Summary for MYO6-SENP6

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO6-SENP6
Fusion gene ID: 56756
HgeneTgene
Gene symbol

MYO6

SENP6

Gene ID

4646

26054

Gene namemyosin VISUMO specific peptidase 6
SynonymsDFNA22|DFNB37SSP1|SUSP1
Cytomap

6q14.1

6q14.1

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-VIunconventional myosin-6sentrin-specific protease 62810017C20RikSUMO-1-specific protease 1SUMO1/sentrin specific peptidase 6SUMO1/sentrin specific protease 6sentrin/SUMO-specific protease SENP6
Modification date2020031320200313
UniProtAcc

Q9UM54

.
Ensembl transtripts involved in fusion geneENST00000369975, ENST00000369977, 
ENST00000369981, ENST00000369985, 
ENST00000462633, 		ENST00000541192, 
ENST00000327284, ENST00000436928, 
ENST00000370010, ENST00000370014, 
ENST00000447266, 
Fusion gene scores* DoF score15 X 13 X 10=195010 X 15 X 5=750
# samples 2216
** MAII scorelog2(22/1950*10)=-3.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/750*10)=-2.22881869049588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO6 [Title/Abstract] AND SENP6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO6(76459140)-SENP6(76405520), # samples:5
SENP6(76312292)-MYO6(76527218), # samples:1
SENP6(76312292)-MYO6(76554614), # samples:1
SENP6(76312292)-MYO6(76558068), # samples:1
Anticipated loss of major functional domain due to fusion event.SENP6-MYO6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SENP6-MYO6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO6

GO:0030330

DNA damage response, signal transduction by p53 class mediator

16507995

TgeneSENP6

GO:0070646

protein modification by small protein removal

20212317


check buttonFusion gene breakpoints across MYO6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SENP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B9-01AMYO6chr6

76459140

+SENP6chr6

76419243

+
ChimerDB4BRCATCGA-D8-A1JM-01AMYO6chr6

76459140

-SENP6chr6

76405520

+
ChimerDB4HNSCTCGA-DQ-7589-01AMYO6chr6

76459140

-SENP6chr6

76419243

+
ChimerDB4LUADTCGA-05-4244-01AMYO6chr6

76459140

-SENP6chr6

76385151

+
ChimerDB4LUADTCGA-05-4244-01AMYO6chr6

76459140

+SENP6chr6

76385151

+
ChimerDB4LUADTCGA-05-4244-01AMYO6chr6

76459140

+SENP6chr6

76385576

+
ChimerDB4LUADTCGA-05-4244MYO6chr6

76459140

+SENP6chr6

76385575

+
ChimerDB4LUADTCGA-44-4112-01AMYO6chr6

76459140

-SENP6chr6

76405520

+
ChimerDB4LUADTCGA-44-4112-01AMYO6chr6

76459140

+SENP6chr6

76405520

+
ChimerDB4STADTCGA-CD-5798-01AMYO6chr6

76459140

+SENP6chr6

76419243

+
ChimerDB4UCECTCGA-AJ-A3EM-01AMYO6chr6

76459140

-SENP6chr6

76405520

+
ChimerDB4UCECTCGA-AJ-A3EM-01AMYO6chr6

76459140

+SENP6chr6

76405520

+
ChimerDB4UCECTCGA-B5-A0JN-01AMYO6chr6

76459140

-SENP6chr6

76423229

+
ChimerDB4UCSTCGA-N5-A4RJ-01AMYO6chr6

76527381

-SENP6chr6

76421044

+


Top

Fusion Gene ORF analysis for MYO6-SENP6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000369975ENST00000541192MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-3UTRENST00000369977ENST00000541192MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-3UTRENST00000369981ENST00000541192MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-3UTRENST00000369985ENST00000541192MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369975ENST00000327284MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369975ENST00000436928MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369977ENST00000327284MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369977ENST00000436928MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369981ENST00000327284MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369981ENST00000436928MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369985ENST00000327284MYO6chr6

76527381

-SENP6chr6

76421044

+
5CDS-intronENST00000369985ENST00000436928MYO6chr6

76527381

-SENP6chr6

76421044

+
5UTR-3CDSENST00000369977ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369977ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369977ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369977ENST00000370010MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369977ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369977ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369977ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369977ENST00000370010MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369977ENST00000370010MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369977ENST00000370014MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369977ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369977ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369977ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369977ENST00000370014MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369977ENST00000370014MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369977ENST00000447266MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369977ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369977ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369977ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369977ENST00000447266MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369977ENST00000447266MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369977ENST00000541192MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369977ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369977ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369977ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369977ENST00000541192MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369981ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369981ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369981ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369981ENST00000370010MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369981ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369981ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369981ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369981ENST00000370010MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369981ENST00000370010MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369981ENST00000370014MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369981ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369981ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369981ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369981ENST00000370014MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369981ENST00000370014MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369981ENST00000447266MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369981ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369981ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369981ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369981ENST00000447266MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369981ENST00000447266MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369981ENST00000541192MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369981ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369981ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369981ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369981ENST00000541192MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369985ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369985ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369985ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369985ENST00000370010MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369985ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369985ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369985ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369985ENST00000370010MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369985ENST00000370010MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369985ENST00000370014MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369985ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369985ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369985ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369985ENST00000370014MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369985ENST00000370014MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369985ENST00000447266MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369985ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369985ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369985ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369985ENST00000447266MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3CDSENST00000369985ENST00000447266MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3CDSENST00000369985ENST00000541192MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-3CDSENST00000369985ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-3CDSENST00000369985ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-3CDSENST00000369985ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-3CDSENST00000369985ENST00000541192MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-3UTRENST00000369977ENST00000541192MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3UTRENST00000369981ENST00000541192MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-3UTRENST00000369985ENST00000541192MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-intronENST00000369977ENST00000327284MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-intronENST00000369977ENST00000327284MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-intronENST00000369977ENST00000327284MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-intronENST00000369977ENST00000436928MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-intronENST00000369977ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-intronENST00000369977ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-intronENST00000369977ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-intronENST00000369977ENST00000436928MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-intronENST00000369977ENST00000436928MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-intronENST00000369981ENST00000327284MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-intronENST00000369981ENST00000327284MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-intronENST00000369981ENST00000327284MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-intronENST00000369981ENST00000436928MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-intronENST00000369981ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-intronENST00000369981ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-intronENST00000369981ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-intronENST00000369981ENST00000436928MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-intronENST00000369981ENST00000436928MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-intronENST00000369985ENST00000327284MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-intronENST00000369985ENST00000327284MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-intronENST00000369985ENST00000327284MYO6chr6

76459140

-SENP6chr6

76423229

+
5UTR-intronENST00000369985ENST00000436928MYO6chr6

76459140

+SENP6chr6

76419243

+
5UTR-intronENST00000369985ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385151

+
5UTR-intronENST00000369985ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385576

+
5UTR-intronENST00000369985ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385575

+
5UTR-intronENST00000369985ENST00000436928MYO6chr6

76459140

+SENP6chr6

76405520

+
5UTR-intronENST00000369985ENST00000436928MYO6chr6

76459140

-SENP6chr6

76423229

+
In-frameENST00000369975ENST00000370010MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369975ENST00000370014MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369975ENST00000447266MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369977ENST00000370010MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369977ENST00000370014MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369977ENST00000447266MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369981ENST00000370010MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369981ENST00000370014MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369981ENST00000447266MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369985ENST00000370010MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369985ENST00000370014MYO6chr6

76527381

-SENP6chr6

76421044

+
In-frameENST00000369985ENST00000447266MYO6chr6

76527381

-SENP6chr6

76421044

+
intron-3CDSENST00000369975ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000369975ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000369975ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000369975ENST00000370010MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000369975ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000369975ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000369975ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000369975ENST00000370010MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3CDSENST00000369975ENST00000370010MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3CDSENST00000369975ENST00000370014MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000369975ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000369975ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000369975ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000369975ENST00000370014MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3CDSENST00000369975ENST00000370014MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3CDSENST00000369975ENST00000447266MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000369975ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000369975ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000369975ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000369975ENST00000447266MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3CDSENST00000369975ENST00000447266MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3CDSENST00000369975ENST00000541192MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000369975ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000369975ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000369975ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000369975ENST00000541192MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3CDSENST00000462633ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000462633ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000462633ENST00000327284MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000462633ENST00000370010MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000462633ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000462633ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000462633ENST00000370010MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000462633ENST00000370010MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3CDSENST00000462633ENST00000370010MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3CDSENST00000462633ENST00000370010MYO6chr6

76527381

-SENP6chr6

76421044

+
intron-3CDSENST00000462633ENST00000370014MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000462633ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000462633ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000462633ENST00000370014MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000462633ENST00000370014MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3CDSENST00000462633ENST00000370014MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3CDSENST00000462633ENST00000370014MYO6chr6

76527381

-SENP6chr6

76421044

+
intron-3CDSENST00000462633ENST00000447266MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000462633ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000462633ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000462633ENST00000447266MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000462633ENST00000447266MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3CDSENST00000462633ENST00000447266MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3CDSENST00000462633ENST00000447266MYO6chr6

76527381

-SENP6chr6

76421044

+
intron-3CDSENST00000462633ENST00000541192MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-3CDSENST00000462633ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-3CDSENST00000462633ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-3CDSENST00000462633ENST00000541192MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-3CDSENST00000462633ENST00000541192MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-3UTRENST00000369975ENST00000541192MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3UTRENST00000462633ENST00000541192MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-3UTRENST00000462633ENST00000541192MYO6chr6

76527381

-SENP6chr6

76421044

+
intron-intronENST00000369975ENST00000327284MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-intronENST00000369975ENST00000327284MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-intronENST00000369975ENST00000327284MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-intronENST00000369975ENST00000436928MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-intronENST00000369975ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-intronENST00000369975ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-intronENST00000369975ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-intronENST00000369975ENST00000436928MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-intronENST00000369975ENST00000436928MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-intronENST00000462633ENST00000327284MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-intronENST00000462633ENST00000327284MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-intronENST00000462633ENST00000327284MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-intronENST00000462633ENST00000327284MYO6chr6

76527381

-SENP6chr6

76421044

+
intron-intronENST00000462633ENST00000436928MYO6chr6

76459140

+SENP6chr6

76419243

+
intron-intronENST00000462633ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385151

+
intron-intronENST00000462633ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385576

+
intron-intronENST00000462633ENST00000436928MYO6chr6

76459140

+SENP6chr6

76385575

+
intron-intronENST00000462633ENST00000436928MYO6chr6

76459140

+SENP6chr6

76405520

+
intron-intronENST00000462633ENST00000436928MYO6chr6

76459140

-SENP6chr6

76423229

+
intron-intronENST00000462633ENST00000436928MYO6chr6

76527381

-SENP6chr6

76421044

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369981MYO6chr676527381-ENST00000370010SENP6chr676421044+1225396279914211
ENST00000369981MYO6chr676527381-ENST00000370014SENP6chr676421044+3602396279914211
ENST00000369981MYO6chr676527381-ENST00000447266SENP6chr676421044+3599396279914211
ENST00000369985MYO6chr676527381-ENST00000370010SENP6chr676421044+1208379262897211
ENST00000369985MYO6chr676527381-ENST00000370014SENP6chr676421044+3585379262897211
ENST00000369985MYO6chr676527381-ENST00000447266SENP6chr676421044+3582379262897211
ENST00000369977MYO6chr676527381-ENST00000370010SENP6chr676421044+1085256139774211
ENST00000369977MYO6chr676527381-ENST00000370014SENP6chr676421044+3462256139774211
ENST00000369977MYO6chr676527381-ENST00000447266SENP6chr676421044+3459256139774211
ENST00000369975MYO6chr676527381-ENST00000370010SENP6chr676421044+97114225660211
ENST00000369975MYO6chr676527381-ENST00000370014SENP6chr676421044+334814225660211
ENST00000369975MYO6chr676527381-ENST00000447266SENP6chr676421044+334514225660211

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369981ENST00000370010MYO6chr676527381-SENP6chr676421044+0.0020374540.9979626
ENST00000369981ENST00000370014MYO6chr676527381-SENP6chr676421044+0.0009632760.9990368
ENST00000369981ENST00000447266MYO6chr676527381-SENP6chr676421044+0.001082080.99891794
ENST00000369985ENST00000370010MYO6chr676527381-SENP6chr676421044+0.0017817960.99821824
ENST00000369985ENST00000370014MYO6chr676527381-SENP6chr676421044+0.0009660210.99903405
ENST00000369985ENST00000447266MYO6chr676527381-SENP6chr676421044+0.0010849030.9989151
ENST00000369977ENST00000370010MYO6chr676527381-SENP6chr676421044+0.002486680.9975133
ENST00000369977ENST00000370014MYO6chr676527381-SENP6chr676421044+0.0010499940.99895006
ENST00000369977ENST00000447266MYO6chr676527381-SENP6chr676421044+0.0011788760.9988211
ENST00000369975ENST00000370010MYO6chr676527381-SENP6chr676421044+0.0027218810.99727815
ENST00000369975ENST00000370014MYO6chr676527381-SENP6chr676421044+0.0010021020.99899787
ENST00000369975ENST00000447266MYO6chr676527381-SENP6chr676421044+0.0011253250.9988746

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Fusion Genomic Features for MYO6-SENP6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYO6-SENP6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:76459140/chr6:76405520)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO6

Q9UM54

.
FUNCTION: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:29467281}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235920_1027391286.0Compositional biasNote=Glu-rich
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233920_1027391263.0Compositional biasNote=Glu-rich
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-2352_53391286.0DomainMyosin N-terminal SH3-like
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-23557_771391286.0DomainMyosin motor
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235814_834391286.0DomainIQ
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-2332_53391263.0DomainMyosin N-terminal SH3-like
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-23357_771391263.0DomainMyosin motor
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233814_834391263.0DomainIQ
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235151_158391286.0Nucleotide bindingATP
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233151_158391263.0Nucleotide bindingATP
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235273_317391286.0RegionResponsible for slow ATPase activity
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235665_672391286.0RegionActin-binding
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235782_810391286.0RegionRequired for binding calmodulin
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235835_916391286.0RegionThree-helix bundle
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-235917_984391286.0RegionSAH
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233273_317391263.0RegionResponsible for slow ATPase activity
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233665_672391263.0RegionActin-binding
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233782_810391263.0RegionRequired for binding calmodulin
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233835_916391263.0RegionThree-helix bundle
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-233917_984391263.0RegionSAH
TgeneSENP6chr6:76527381chr6:76421044ENST000003700101823666_11129331106.0RegionNote=Protease
TgeneSENP6chr6:76527381chr6:76421044ENST000004472661924666_11129401113.0RegionNote=Protease


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Fusion Gene Sequence for MYO6-SENP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56756_56756_1_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369975_SENP6_chr6_76421044_ENST00000370010_length(transcript)=971nt_BP=142nt
GGAGATCGTGGATCCTCCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGT
GGATATTGGCCCCGACAGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAA
CTGCAGTTCAGAAATAGGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTC
TCGGTCAAATGTTGTCAAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGT
TATGAAGGGCTCTAATCCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGA
GAATCCAATTCTCAGTTTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAA
CATAATTCTGAAGCTACAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAAC
AGAACAATATGTCAATAGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTA
TAGACAATAAAGAACTGAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGT
ATGTATTAAGTAAAAGTCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGT

>56756_56756_1_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369975_SENP6_chr6_76421044_ENST00000370010_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_2_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369975_SENP6_chr6_76421044_ENST00000370014_length(transcript)=3348nt_BP=142nt
GGAGATCGTGGATCCTCCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGT
GGATATTGGCCCCGACAGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAA
CTGCAGTTCAGAAATAGGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTC
TCGGTCAAATGTTGTCAAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGT
TATGAAGGGCTCTAATCCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGA
GAATCCAATTCTCAGTTTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAA
CATAATTCTGAAGCTACAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAAC
AGAACAATATGTCAATAGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTA
TAGACAATAAAGAACTGAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGT
ATGTATTAAGTAAAAGTCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGT
TATGTATTTTCTGTTAATAGTACCTAAAATTGCAACTTCTAAACACAAATAAAAAGAAAATATTTATAGGAGGAAATGATTAATTTGATA
TTCTTTAGTGAACTTGTTTAATTCCTCAGTGGGTGTGACATATTTCATGGGAATATTCAAATATCTATGGTAATATTTTGACCCTTTATA
TTTGTTCTAAAATAAGTCAAAATGTGAAAATAATATTAAATCTAAGATATTTTGAACTAAGCATCTTTATATGCTTGTGTAACAGGAACA
AAGTAACAGCCTTTCAATTCATATACTGCCTTGTGTTCAGTGAACCCAAGAAATGTAATAAATATTTGTAATTTTACACAAATATTTAAG
AGGAAAGAGTATTAAGAGCAATTCAAAAAAAGTAACCTTATACTACTAAAAAAAAAATTCTTGCATATATTATCATCAAATGCATTTTTG
AAGACATCAAAGACTCAGGTTAAAACTATTTTGGTAAGTGCAGCTTGAATTTCAAATATCCCGTGTTACCTTTCTCTATTACAGCTTAAA
GTATGCTACAATCTGTGTCATATAGTTAATTGATAAGCATTTTTAATCTGTGTAAACACAGGAATTTAAATAGGAATTTACTATTTTTTT
ATAAAGCTTTTGCTATTTTTTCATTGCTCATTTTGTTCTTATTATTTTGATAAAGTATCAGACTTTTTGCTTGAGTTCTTCAGTGTAAAT
TATTTTTTACATGTAAAAGTACTGTATTCAACCAGTTGCATAATACAGCAAAAATCTTTGAATTCCCCTTTAAAATAACTAAAATTTGAT
GGTTTCCATGACAGATTTATAGCACATATAGGGATCTTGCATGTATCTGCAGAAACTTCATTATTTTTCAAATGAAATGGTGTATACTTC
TTTCAAATGAACTTTGAGACTTGAAACATATTTTAGTCATTTTTTGTTAAATATTGAATTTTTAAATACACATATATCAAAAATAGTTGA
GAATAAAAAGAAAGCCTAATCATCAGCAATTATTTTATTTTTAATTTGGCCATCTCTGACATTGCAGTCAATATCTTAGGGTATTTTCTT
GAATTTAATAAAGTCCCATGGGTGGGTTCAGGGTGAATGGGAGTATTAACAACAACCAAAAAATATCTATTGAGACACAGTAGAGTCTCA
GTAAGAGAAATATTAAAATGTAAGAAAGGTCACCATTAGTGATATCAACTGTAGTTTGTTACTTTGAACTATATTTCTGATTAACTCTTT
ATAGTAATAACTTAGAGCTGTTAGCTCAGATATCTTAATTAGCTCATATGAAAAACAAGTTTAATTTTATTATTTACTGAACATGGCAAA
ATGCTTTTCAATCTATAATAAAACTGGGATAAAAAATTGAAGTTGTTTTTTTTAAAACCTAATAGCAATAAGCAAAATTGGCATACATAA
TTTTTTTAATGAACTATATTTTGTCAGAATCTGAAGGTACTGAAAAACTATTCTAAAATGCCTACTTGTTTTTGCATTAATTTGTAATGC
TTACATTTTGCACCCTTAGATAATGTTTGATAAGATAAAAATATAATTTATCCCTTGTACCAACTCAAGTCAATCAGATTTTAACATGAA
AAATATAGATTAATGTATGTCAGCTTTCTAGAGGTAGAATACTCAGCTATTTGATGGCATTTTTCCCACCCCATGTGAAATTTTATTTTT
GGAAGTTATGCTAGTGACATTGCAATATATATTGAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAAAACTAGACTTGAGAATCTTTCGTG
TATATGCACATTCACTTGATAATTGTGTATTCTATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAATGTGTTATTAGTACTTAGAAGTTG
TAAAACAGAACTTATAGAGGTTTGTTACTAGACACTGAAACTGCATGACAAGTATCTGGTGTCTTAACTAATTAGATAGATCTGTTGTAT
TGGTTTTCTTGTTGGATAGAATAACAGTTAATCATTTTTAGAAGAGTTTTAGATTACTTGCCATAAAATTTGTATGTCTCAGCTCTTGTT
GGTTTAGGAGCAGAAGTGGTGTTTAGTCCCTTCCCGTTAATGTTGCTGTGCTACTTCAGACAGCTGAAAACTTAATGGTATTATTTCAAG
TTCACATAACCCTAAAAAAGGTTTTCTTTGTGTAGTAACTTGTGCTTAAACTTTTAGTCAATTAAATGTAGGAGGTTTTATTTGAAAACA
TAAAATGATTCTCTAAATTACATCTTGTTTTAAGCCACCAAAATGAATGCAGTAATTTTTCTTTAAAAAAATGATCTCTGAAAACTGTGA
GACAATGTAAAAAGAATAAGTTTTAATTCCCCCAAAATCAAAAATTGTACTTAAAATCTCAGACAATTCACTGAACAGGAATAATAAAGA

>56756_56756_2_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369975_SENP6_chr6_76421044_ENST00000370014_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_3_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369975_SENP6_chr6_76421044_ENST00000447266_length(transcript)=3345nt_BP=142nt
GGAGATCGTGGATCCTCCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGT
GGATATTGGCCCCGACAGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAA
CTGCAGTTCAGAAATAGGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTC
TCGGTCAAATGTTGTCAAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGT
TATGAAGGGCTCTAATCCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGA
GAATCCAATTCTCAGTTTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAA
CATAATTCTGAAGCTACAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAAC
AGAACAATATGTCAATAGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTA
TAGACAATAAAGAACTGAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGT
ATGTATTAAGTAAAAGTCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGT
TATGTATTTTCTGTTAATAGTACCTAAAATTGCAACTTCTAAACACAAATAAAAAGAAAATATTTATAGGAGGAAATGATTAATTTGATA
TTCTTTAGTGAACTTGTTTAATTCCTCAGTGGGTGTGACATATTTCATGGGAATATTCAAATATCTATGGTAATATTTTGACCCTTTATA
TTTGTTCTAAAATAAGTCAAAATGTGAAAATAATATTAAATCTAAGATATTTTGAACTAAGCATCTTTATATGCTTGTGTAACAGGAACA
AAGTAACAGCCTTTCAATTCATATACTGCCTTGTGTTCAGTGAACCCAAGAAATGTAATAAATATTTGTAATTTTACACAAATATTTAAG
AGGAAAGAGTATTAAGAGCAATTCAAAAAAAGTAACCTTATACTACTAAAAAAAAAATTCTTGCATATATTATCATCAAATGCATTTTTG
AAGACATCAAAGACTCAGGTTAAAACTATTTTGGTAAGTGCAGCTTGAATTTCAAATATCCCGTGTTACCTTTCTCTATTACAGCTTAAA
GTATGCTACAATCTGTGTCATATAGTTAATTGATAAGCATTTTTAATCTGTGTAAACACAGGAATTTAAATAGGAATTTACTATTTTTTT
ATAAAGCTTTTGCTATTTTTTCATTGCTCATTTTGTTCTTATTATTTTGATAAAGTATCAGACTTTTTGCTTGAGTTCTTCAGTGTAAAT
TATTTTTTACATGTAAAAGTACTGTATTCAACCAGTTGCATAATACAGCAAAAATCTTTGAATTCCCCTTTAAAATAACTAAAATTTGAT
GGTTTCCATGACAGATTTATAGCACATATAGGGATCTTGCATGTATCTGCAGAAACTTCATTATTTTTCAAATGAAATGGTGTATACTTC
TTTCAAATGAACTTTGAGACTTGAAACATATTTTAGTCATTTTTTGTTAAATATTGAATTTTTAAATACACATATATCAAAAATAGTTGA
GAATAAAAAGAAAGCCTAATCATCAGCAATTATTTTATTTTTAATTTGGCCATCTCTGACATTGCAGTCAATATCTTAGGGTATTTTCTT
GAATTTAATAAAGTCCCATGGGTGGGTTCAGGGTGAATGGGAGTATTAACAACAACCAAAAAATATCTATTGAGACACAGTAGAGTCTCA
GTAAGAGAAATATTAAAATGTAAGAAAGGTCACCATTAGTGATATCAACTGTAGTTTGTTACTTTGAACTATATTTCTGATTAACTCTTT
ATAGTAATAACTTAGAGCTGTTAGCTCAGATATCTTAATTAGCTCATATGAAAAACAAGTTTAATTTTATTATTTACTGAACATGGCAAA
ATGCTTTTCAATCTATAATAAAACTGGGATAAAAAATTGAAGTTGTTTTTTTTAAAACCTAATAGCAATAAGCAAAATTGGCATACATAA
TTTTTTTAATGAACTATATTTTGTCAGAATCTGAAGGTACTGAAAAACTATTCTAAAATGCCTACTTGTTTTTGCATTAATTTGTAATGC
TTACATTTTGCACCCTTAGATAATGTTTGATAAGATAAAAATATAATTTATCCCTTGTACCAACTCAAGTCAATCAGATTTTAACATGAA
AAATATAGATTAATGTATGTCAGCTTTCTAGAGGTAGAATACTCAGCTATTTGATGGCATTTTTCCCACCCCATGTGAAATTTTATTTTT
GGAAGTTATGCTAGTGACATTGCAATATATATTGAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAAAACTAGACTTGAGAATCTTTCGTG
TATATGCACATTCACTTGATAATTGTGTATTCTATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAATGTGTTATTAGTACTTAGAAGTTG
TAAAACAGAACTTATAGAGGTTTGTTACTAGACACTGAAACTGCATGACAAGTATCTGGTGTCTTAACTAATTAGATAGATCTGTTGTAT
TGGTTTTCTTGTTGGATAGAATAACAGTTAATCATTTTTAGAAGAGTTTTAGATTACTTGCCATAAAATTTGTATGTCTCAGCTCTTGTT
GGTTTAGGAGCAGAAGTGGTGTTTAGTCCCTTCCCGTTAATGTTGCTGTGCTACTTCAGACAGCTGAAAACTTAATGGTATTATTTCAAG
TTCACATAACCCTAAAAAAGGTTTTCTTTGTGTAGTAACTTGTGCTTAAACTTTTAGTCAATTAAATGTAGGAGGTTTTATTTGAAAACA
TAAAATGATTCTCTAAATTACATCTTGTTTTAAGCCACCAAAATGAATGCAGTAATTTTTCTTTAAAAAAATGATCTCTGAAAACTGTGA
GACAATGTAAAAAGAATAAGTTTTAATTCCCCCAAAATCAAAAATTGTACTTAAAATCTCAGACAATTCACTGAACAGGAATAATAAAGA

>56756_56756_3_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369975_SENP6_chr6_76421044_ENST00000447266_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_4_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369977_SENP6_chr6_76421044_ENST00000370010_length(transcript)=1085nt_BP=256nt
CTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCTTCACCCGTACAGGTAGCCCCGCCGCCGCGCACCTGCCTTCGCTCCCGCAC
CGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCTCCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGA
TGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGACAGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGA
CGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATAGGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACT
TATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTCAAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAG
CAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAATCCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATT
GCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGTTTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAG
AACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTACAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAAC
AGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAATAGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAA
CTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACTGAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGT
CAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAGTCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTT
TTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTAATAGTACCTAAAATTGCAACTTCTAAACACAAATAAAAAGAAAATATTTA

>56756_56756_4_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369977_SENP6_chr6_76421044_ENST00000370010_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_5_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369977_SENP6_chr6_76421044_ENST00000370014_length(transcript)=3462nt_BP=256nt
CTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCTTCACCCGTACAGGTAGCCCCGCCGCCGCGCACCTGCCTTCGCTCCCGCAC
CGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCTCCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGA
TGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGACAGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGA
CGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATAGGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACT
TATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTCAAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAG
CAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAATCCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATT
GCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGTTTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAG
AACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTACAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAAC
AGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAATAGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAA
CTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACTGAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGT
CAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAGTCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTT
TTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTAATAGTACCTAAAATTGCAACTTCTAAACACAAATAAAAAGAAAATATTTA
TAGGAGGAAATGATTAATTTGATATTCTTTAGTGAACTTGTTTAATTCCTCAGTGGGTGTGACATATTTCATGGGAATATTCAAATATCT
ATGGTAATATTTTGACCCTTTATATTTGTTCTAAAATAAGTCAAAATGTGAAAATAATATTAAATCTAAGATATTTTGAACTAAGCATCT
TTATATGCTTGTGTAACAGGAACAAAGTAACAGCCTTTCAATTCATATACTGCCTTGTGTTCAGTGAACCCAAGAAATGTAATAAATATT
TGTAATTTTACACAAATATTTAAGAGGAAAGAGTATTAAGAGCAATTCAAAAAAAGTAACCTTATACTACTAAAAAAAAAATTCTTGCAT
ATATTATCATCAAATGCATTTTTGAAGACATCAAAGACTCAGGTTAAAACTATTTTGGTAAGTGCAGCTTGAATTTCAAATATCCCGTGT
TACCTTTCTCTATTACAGCTTAAAGTATGCTACAATCTGTGTCATATAGTTAATTGATAAGCATTTTTAATCTGTGTAAACACAGGAATT
TAAATAGGAATTTACTATTTTTTTATAAAGCTTTTGCTATTTTTTCATTGCTCATTTTGTTCTTATTATTTTGATAAAGTATCAGACTTT
TTGCTTGAGTTCTTCAGTGTAAATTATTTTTTACATGTAAAAGTACTGTATTCAACCAGTTGCATAATACAGCAAAAATCTTTGAATTCC
CCTTTAAAATAACTAAAATTTGATGGTTTCCATGACAGATTTATAGCACATATAGGGATCTTGCATGTATCTGCAGAAACTTCATTATTT
TTCAAATGAAATGGTGTATACTTCTTTCAAATGAACTTTGAGACTTGAAACATATTTTAGTCATTTTTTGTTAAATATTGAATTTTTAAA
TACACATATATCAAAAATAGTTGAGAATAAAAAGAAAGCCTAATCATCAGCAATTATTTTATTTTTAATTTGGCCATCTCTGACATTGCA
GTCAATATCTTAGGGTATTTTCTTGAATTTAATAAAGTCCCATGGGTGGGTTCAGGGTGAATGGGAGTATTAACAACAACCAAAAAATAT
CTATTGAGACACAGTAGAGTCTCAGTAAGAGAAATATTAAAATGTAAGAAAGGTCACCATTAGTGATATCAACTGTAGTTTGTTACTTTG
AACTATATTTCTGATTAACTCTTTATAGTAATAACTTAGAGCTGTTAGCTCAGATATCTTAATTAGCTCATATGAAAAACAAGTTTAATT
TTATTATTTACTGAACATGGCAAAATGCTTTTCAATCTATAATAAAACTGGGATAAAAAATTGAAGTTGTTTTTTTTAAAACCTAATAGC
AATAAGCAAAATTGGCATACATAATTTTTTTAATGAACTATATTTTGTCAGAATCTGAAGGTACTGAAAAACTATTCTAAAATGCCTACT
TGTTTTTGCATTAATTTGTAATGCTTACATTTTGCACCCTTAGATAATGTTTGATAAGATAAAAATATAATTTATCCCTTGTACCAACTC
AAGTCAATCAGATTTTAACATGAAAAATATAGATTAATGTATGTCAGCTTTCTAGAGGTAGAATACTCAGCTATTTGATGGCATTTTTCC
CACCCCATGTGAAATTTTATTTTTGGAAGTTATGCTAGTGACATTGCAATATATATTGAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAA
AACTAGACTTGAGAATCTTTCGTGTATATGCACATTCACTTGATAATTGTGTATTCTATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAA
TGTGTTATTAGTACTTAGAAGTTGTAAAACAGAACTTATAGAGGTTTGTTACTAGACACTGAAACTGCATGACAAGTATCTGGTGTCTTA
ACTAATTAGATAGATCTGTTGTATTGGTTTTCTTGTTGGATAGAATAACAGTTAATCATTTTTAGAAGAGTTTTAGATTACTTGCCATAA
AATTTGTATGTCTCAGCTCTTGTTGGTTTAGGAGCAGAAGTGGTGTTTAGTCCCTTCCCGTTAATGTTGCTGTGCTACTTCAGACAGCTG
AAAACTTAATGGTATTATTTCAAGTTCACATAACCCTAAAAAAGGTTTTCTTTGTGTAGTAACTTGTGCTTAAACTTTTAGTCAATTAAA
TGTAGGAGGTTTTATTTGAAAACATAAAATGATTCTCTAAATTACATCTTGTTTTAAGCCACCAAAATGAATGCAGTAATTTTTCTTTAA
AAAAATGATCTCTGAAAACTGTGAGACAATGTAAAAAGAATAAGTTTTAATTCCCCCAAAATCAAAAATTGTACTTAAAATCTCAGACAA

>56756_56756_5_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369977_SENP6_chr6_76421044_ENST00000370014_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_6_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369977_SENP6_chr6_76421044_ENST00000447266_length(transcript)=3459nt_BP=256nt
CTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCTTCACCCGTACAGGTAGCCCCGCCGCCGCGCACCTGCCTTCGCTCCCGCAC
CGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCTCCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGA
TGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGACAGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGA
CGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATAGGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACT
TATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTCAAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAG
CAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAATCCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATT
GCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGTTTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAG
AACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTACAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAAC
AGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAATAGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAA
CTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACTGAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGT
CAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAGTCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTT
TTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTAATAGTACCTAAAATTGCAACTTCTAAACACAAATAAAAAGAAAATATTTA
TAGGAGGAAATGATTAATTTGATATTCTTTAGTGAACTTGTTTAATTCCTCAGTGGGTGTGACATATTTCATGGGAATATTCAAATATCT
ATGGTAATATTTTGACCCTTTATATTTGTTCTAAAATAAGTCAAAATGTGAAAATAATATTAAATCTAAGATATTTTGAACTAAGCATCT
TTATATGCTTGTGTAACAGGAACAAAGTAACAGCCTTTCAATTCATATACTGCCTTGTGTTCAGTGAACCCAAGAAATGTAATAAATATT
TGTAATTTTACACAAATATTTAAGAGGAAAGAGTATTAAGAGCAATTCAAAAAAAGTAACCTTATACTACTAAAAAAAAAATTCTTGCAT
ATATTATCATCAAATGCATTTTTGAAGACATCAAAGACTCAGGTTAAAACTATTTTGGTAAGTGCAGCTTGAATTTCAAATATCCCGTGT
TACCTTTCTCTATTACAGCTTAAAGTATGCTACAATCTGTGTCATATAGTTAATTGATAAGCATTTTTAATCTGTGTAAACACAGGAATT
TAAATAGGAATTTACTATTTTTTTATAAAGCTTTTGCTATTTTTTCATTGCTCATTTTGTTCTTATTATTTTGATAAAGTATCAGACTTT
TTGCTTGAGTTCTTCAGTGTAAATTATTTTTTACATGTAAAAGTACTGTATTCAACCAGTTGCATAATACAGCAAAAATCTTTGAATTCC
CCTTTAAAATAACTAAAATTTGATGGTTTCCATGACAGATTTATAGCACATATAGGGATCTTGCATGTATCTGCAGAAACTTCATTATTT
TTCAAATGAAATGGTGTATACTTCTTTCAAATGAACTTTGAGACTTGAAACATATTTTAGTCATTTTTTGTTAAATATTGAATTTTTAAA
TACACATATATCAAAAATAGTTGAGAATAAAAAGAAAGCCTAATCATCAGCAATTATTTTATTTTTAATTTGGCCATCTCTGACATTGCA
GTCAATATCTTAGGGTATTTTCTTGAATTTAATAAAGTCCCATGGGTGGGTTCAGGGTGAATGGGAGTATTAACAACAACCAAAAAATAT
CTATTGAGACACAGTAGAGTCTCAGTAAGAGAAATATTAAAATGTAAGAAAGGTCACCATTAGTGATATCAACTGTAGTTTGTTACTTTG
AACTATATTTCTGATTAACTCTTTATAGTAATAACTTAGAGCTGTTAGCTCAGATATCTTAATTAGCTCATATGAAAAACAAGTTTAATT
TTATTATTTACTGAACATGGCAAAATGCTTTTCAATCTATAATAAAACTGGGATAAAAAATTGAAGTTGTTTTTTTTAAAACCTAATAGC
AATAAGCAAAATTGGCATACATAATTTTTTTAATGAACTATATTTTGTCAGAATCTGAAGGTACTGAAAAACTATTCTAAAATGCCTACT
TGTTTTTGCATTAATTTGTAATGCTTACATTTTGCACCCTTAGATAATGTTTGATAAGATAAAAATATAATTTATCCCTTGTACCAACTC
AAGTCAATCAGATTTTAACATGAAAAATATAGATTAATGTATGTCAGCTTTCTAGAGGTAGAATACTCAGCTATTTGATGGCATTTTTCC
CACCCCATGTGAAATTTTATTTTTGGAAGTTATGCTAGTGACATTGCAATATATATTGAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAA
AACTAGACTTGAGAATCTTTCGTGTATATGCACATTCACTTGATAATTGTGTATTCTATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAA
TGTGTTATTAGTACTTAGAAGTTGTAAAACAGAACTTATAGAGGTTTGTTACTAGACACTGAAACTGCATGACAAGTATCTGGTGTCTTA
ACTAATTAGATAGATCTGTTGTATTGGTTTTCTTGTTGGATAGAATAACAGTTAATCATTTTTAGAAGAGTTTTAGATTACTTGCCATAA
AATTTGTATGTCTCAGCTCTTGTTGGTTTAGGAGCAGAAGTGGTGTTTAGTCCCTTCCCGTTAATGTTGCTGTGCTACTTCAGACAGCTG
AAAACTTAATGGTATTATTTCAAGTTCACATAACCCTAAAAAAGGTTTTCTTTGTGTAGTAACTTGTGCTTAAACTTTTAGTCAATTAAA
TGTAGGAGGTTTTATTTGAAAACATAAAATGATTCTCTAAATTACATCTTGTTTTAAGCCACCAAAATGAATGCAGTAATTTTTCTTTAA
AAAAATGATCTCTGAAAACTGTGAGACAATGTAAAAAGAATAAGTTTTAATTCCCCCAAAATCAAAAATTGTACTTAAAATCTCAGACAA

>56756_56756_6_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369977_SENP6_chr6_76421044_ENST00000447266_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_7_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369981_SENP6_chr6_76421044_ENST00000370010_length(transcript)=1225nt_BP=396nt
GTGCACGCCGCAGTGCCGGGGACTCGGCGGGGCGCCGGCCGGCGGGCGGAGACCGACTCGGGATCTGTCCGAGCAGGAAGCCAGCCTCAG
CCCGGCCGCTGTCGCCGCCCTGTCCTGGTGCCCGTCCGCGTCGTCGCCCTCTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCT
TCACCCGTACAGGTAGCCCCGCCGCCGCGCACCTGCCTTCGCTCCCGCACCGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCT
CCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGAC
AGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATA
GGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTC
AAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAAT
CCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGT
TTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTA
CAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAAT
AGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACT
GAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAG
TCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTA

>56756_56756_7_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369981_SENP6_chr6_76421044_ENST00000370010_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_8_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369981_SENP6_chr6_76421044_ENST00000370014_length(transcript)=3602nt_BP=396nt
GTGCACGCCGCAGTGCCGGGGACTCGGCGGGGCGCCGGCCGGCGGGCGGAGACCGACTCGGGATCTGTCCGAGCAGGAAGCCAGCCTCAG
CCCGGCCGCTGTCGCCGCCCTGTCCTGGTGCCCGTCCGCGTCGTCGCCCTCTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCT
TCACCCGTACAGGTAGCCCCGCCGCCGCGCACCTGCCTTCGCTCCCGCACCGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCT
CCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGAC
AGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATA
GGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTC
AAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAAT
CCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGT
TTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTA
CAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAAT
AGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACT
GAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAG
TCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTA
ATAGTACCTAAAATTGCAACTTCTAAACACAAATAAAAAGAAAATATTTATAGGAGGAAATGATTAATTTGATATTCTTTAGTGAACTTG
TTTAATTCCTCAGTGGGTGTGACATATTTCATGGGAATATTCAAATATCTATGGTAATATTTTGACCCTTTATATTTGTTCTAAAATAAG
TCAAAATGTGAAAATAATATTAAATCTAAGATATTTTGAACTAAGCATCTTTATATGCTTGTGTAACAGGAACAAAGTAACAGCCTTTCA
ATTCATATACTGCCTTGTGTTCAGTGAACCCAAGAAATGTAATAAATATTTGTAATTTTACACAAATATTTAAGAGGAAAGAGTATTAAG
AGCAATTCAAAAAAAGTAACCTTATACTACTAAAAAAAAAATTCTTGCATATATTATCATCAAATGCATTTTTGAAGACATCAAAGACTC
AGGTTAAAACTATTTTGGTAAGTGCAGCTTGAATTTCAAATATCCCGTGTTACCTTTCTCTATTACAGCTTAAAGTATGCTACAATCTGT
GTCATATAGTTAATTGATAAGCATTTTTAATCTGTGTAAACACAGGAATTTAAATAGGAATTTACTATTTTTTTATAAAGCTTTTGCTAT
TTTTTCATTGCTCATTTTGTTCTTATTATTTTGATAAAGTATCAGACTTTTTGCTTGAGTTCTTCAGTGTAAATTATTTTTTACATGTAA
AAGTACTGTATTCAACCAGTTGCATAATACAGCAAAAATCTTTGAATTCCCCTTTAAAATAACTAAAATTTGATGGTTTCCATGACAGAT
TTATAGCACATATAGGGATCTTGCATGTATCTGCAGAAACTTCATTATTTTTCAAATGAAATGGTGTATACTTCTTTCAAATGAACTTTG
AGACTTGAAACATATTTTAGTCATTTTTTGTTAAATATTGAATTTTTAAATACACATATATCAAAAATAGTTGAGAATAAAAAGAAAGCC
TAATCATCAGCAATTATTTTATTTTTAATTTGGCCATCTCTGACATTGCAGTCAATATCTTAGGGTATTTTCTTGAATTTAATAAAGTCC
CATGGGTGGGTTCAGGGTGAATGGGAGTATTAACAACAACCAAAAAATATCTATTGAGACACAGTAGAGTCTCAGTAAGAGAAATATTAA
AATGTAAGAAAGGTCACCATTAGTGATATCAACTGTAGTTTGTTACTTTGAACTATATTTCTGATTAACTCTTTATAGTAATAACTTAGA
GCTGTTAGCTCAGATATCTTAATTAGCTCATATGAAAAACAAGTTTAATTTTATTATTTACTGAACATGGCAAAATGCTTTTCAATCTAT
AATAAAACTGGGATAAAAAATTGAAGTTGTTTTTTTTAAAACCTAATAGCAATAAGCAAAATTGGCATACATAATTTTTTTAATGAACTA
TATTTTGTCAGAATCTGAAGGTACTGAAAAACTATTCTAAAATGCCTACTTGTTTTTGCATTAATTTGTAATGCTTACATTTTGCACCCT
TAGATAATGTTTGATAAGATAAAAATATAATTTATCCCTTGTACCAACTCAAGTCAATCAGATTTTAACATGAAAAATATAGATTAATGT
ATGTCAGCTTTCTAGAGGTAGAATACTCAGCTATTTGATGGCATTTTTCCCACCCCATGTGAAATTTTATTTTTGGAAGTTATGCTAGTG
ACATTGCAATATATATTGAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAAAACTAGACTTGAGAATCTTTCGTGTATATGCACATTCACT
TGATAATTGTGTATTCTATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAATGTGTTATTAGTACTTAGAAGTTGTAAAACAGAACTTATA
GAGGTTTGTTACTAGACACTGAAACTGCATGACAAGTATCTGGTGTCTTAACTAATTAGATAGATCTGTTGTATTGGTTTTCTTGTTGGA
TAGAATAACAGTTAATCATTTTTAGAAGAGTTTTAGATTACTTGCCATAAAATTTGTATGTCTCAGCTCTTGTTGGTTTAGGAGCAGAAG
TGGTGTTTAGTCCCTTCCCGTTAATGTTGCTGTGCTACTTCAGACAGCTGAAAACTTAATGGTATTATTTCAAGTTCACATAACCCTAAA
AAAGGTTTTCTTTGTGTAGTAACTTGTGCTTAAACTTTTAGTCAATTAAATGTAGGAGGTTTTATTTGAAAACATAAAATGATTCTCTAA
ATTACATCTTGTTTTAAGCCACCAAAATGAATGCAGTAATTTTTCTTTAAAAAAATGATCTCTGAAAACTGTGAGACAATGTAAAAAGAA
TAAGTTTTAATTCCCCCAAAATCAAAAATTGTACTTAAAATCTCAGACAATTCACTGAACAGGAATAATAAAGAACATATTTTAATATAT

>56756_56756_8_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369981_SENP6_chr6_76421044_ENST00000370014_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_9_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369981_SENP6_chr6_76421044_ENST00000447266_length(transcript)=3599nt_BP=396nt
GTGCACGCCGCAGTGCCGGGGACTCGGCGGGGCGCCGGCCGGCGGGCGGAGACCGACTCGGGATCTGTCCGAGCAGGAAGCCAGCCTCAG
CCCGGCCGCTGTCGCCGCCCTGTCCTGGTGCCCGTCCGCGTCGTCGCCCTCTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCT
TCACCCGTACAGGTAGCCCCGCCGCCGCGCACCTGCCTTCGCTCCCGCACCGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCT
CCTTCAAAAATGGAGGATGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGAC
AGCTTAACAATTGAACCCTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATA
GGACAGTGGCATTTAAAGCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTC
AAAATTTTAAGAGAGTATTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAAT
CCAAAAGTACCACAGCAAAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGT
TTTGAACTACCTATGAATTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTA
CAGGAAGATCAGAGCAAAGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAAT
AGTATCTCAGATTGACCATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACT
GAAGTGCTCACTACTCAGTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAG
TCTGTAAATATGTTAATGAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTA
ATAGTACCTAAAATTGCAACTTCTAAACACAAATAAAAAGAAAATATTTATAGGAGGAAATGATTAATTTGATATTCTTTAGTGAACTTG
TTTAATTCCTCAGTGGGTGTGACATATTTCATGGGAATATTCAAATATCTATGGTAATATTTTGACCCTTTATATTTGTTCTAAAATAAG
TCAAAATGTGAAAATAATATTAAATCTAAGATATTTTGAACTAAGCATCTTTATATGCTTGTGTAACAGGAACAAAGTAACAGCCTTTCA
ATTCATATACTGCCTTGTGTTCAGTGAACCCAAGAAATGTAATAAATATTTGTAATTTTACACAAATATTTAAGAGGAAAGAGTATTAAG
AGCAATTCAAAAAAAGTAACCTTATACTACTAAAAAAAAAATTCTTGCATATATTATCATCAAATGCATTTTTGAAGACATCAAAGACTC
AGGTTAAAACTATTTTGGTAAGTGCAGCTTGAATTTCAAATATCCCGTGTTACCTTTCTCTATTACAGCTTAAAGTATGCTACAATCTGT
GTCATATAGTTAATTGATAAGCATTTTTAATCTGTGTAAACACAGGAATTTAAATAGGAATTTACTATTTTTTTATAAAGCTTTTGCTAT
TTTTTCATTGCTCATTTTGTTCTTATTATTTTGATAAAGTATCAGACTTTTTGCTTGAGTTCTTCAGTGTAAATTATTTTTTACATGTAA
AAGTACTGTATTCAACCAGTTGCATAATACAGCAAAAATCTTTGAATTCCCCTTTAAAATAACTAAAATTTGATGGTTTCCATGACAGAT
TTATAGCACATATAGGGATCTTGCATGTATCTGCAGAAACTTCATTATTTTTCAAATGAAATGGTGTATACTTCTTTCAAATGAACTTTG
AGACTTGAAACATATTTTAGTCATTTTTTGTTAAATATTGAATTTTTAAATACACATATATCAAAAATAGTTGAGAATAAAAAGAAAGCC
TAATCATCAGCAATTATTTTATTTTTAATTTGGCCATCTCTGACATTGCAGTCAATATCTTAGGGTATTTTCTTGAATTTAATAAAGTCC
CATGGGTGGGTTCAGGGTGAATGGGAGTATTAACAACAACCAAAAAATATCTATTGAGACACAGTAGAGTCTCAGTAAGAGAAATATTAA
AATGTAAGAAAGGTCACCATTAGTGATATCAACTGTAGTTTGTTACTTTGAACTATATTTCTGATTAACTCTTTATAGTAATAACTTAGA
GCTGTTAGCTCAGATATCTTAATTAGCTCATATGAAAAACAAGTTTAATTTTATTATTTACTGAACATGGCAAAATGCTTTTCAATCTAT
AATAAAACTGGGATAAAAAATTGAAGTTGTTTTTTTTAAAACCTAATAGCAATAAGCAAAATTGGCATACATAATTTTTTTAATGAACTA
TATTTTGTCAGAATCTGAAGGTACTGAAAAACTATTCTAAAATGCCTACTTGTTTTTGCATTAATTTGTAATGCTTACATTTTGCACCCT
TAGATAATGTTTGATAAGATAAAAATATAATTTATCCCTTGTACCAACTCAAGTCAATCAGATTTTAACATGAAAAATATAGATTAATGT
ATGTCAGCTTTCTAGAGGTAGAATACTCAGCTATTTGATGGCATTTTTCCCACCCCATGTGAAATTTTATTTTTGGAAGTTATGCTAGTG
ACATTGCAATATATATTGAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAAAACTAGACTTGAGAATCTTTCGTGTATATGCACATTCACT
TGATAATTGTGTATTCTATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAATGTGTTATTAGTACTTAGAAGTTGTAAAACAGAACTTATA
GAGGTTTGTTACTAGACACTGAAACTGCATGACAAGTATCTGGTGTCTTAACTAATTAGATAGATCTGTTGTATTGGTTTTCTTGTTGGA
TAGAATAACAGTTAATCATTTTTAGAAGAGTTTTAGATTACTTGCCATAAAATTTGTATGTCTCAGCTCTTGTTGGTTTAGGAGCAGAAG
TGGTGTTTAGTCCCTTCCCGTTAATGTTGCTGTGCTACTTCAGACAGCTGAAAACTTAATGGTATTATTTCAAGTTCACATAACCCTAAA
AAAGGTTTTCTTTGTGTAGTAACTTGTGCTTAAACTTTTAGTCAATTAAATGTAGGAGGTTTTATTTGAAAACATAAAATGATTCTCTAA
ATTACATCTTGTTTTAAGCCACCAAAATGAATGCAGTAATTTTTCTTTAAAAAAATGATCTCTGAAAACTGTGAGACAATGTAAAAAGAA

>56756_56756_9_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369981_SENP6_chr6_76421044_ENST00000447266_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_10_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369985_SENP6_chr6_76421044_ENST00000370010_length(transcript)=1208nt_BP=379nt
GGGGACTCGGCGGGGCGCCGGCCGGCGGGCGGAGACCGACTCGGGATCTGTCCGAGCAGGAAGCCAGCCTCAGCCCGGCCGCTGTCGCCG
CCCTGTCCTGGTGCCCGTCCGCGTCGTCGCCCTCTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCTTCACCCGTACAGGTAGC
CCCGCCGCCGCGCACCTGCCTTCGCTCCCGCACCGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCTCCTTCAAAAATGGAGGA
TGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGACAGCTTAACAATTGAACC
CTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATAGGACAGTGGCATTTAAA
GCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTCAAAATTTTAAGAGAGTA
TTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAATCCAAAAGTACCACAGCA
AAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGTTTTGAACTACCTATGAA
TTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTACAGGAAGATCAGAGCAA
AGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAATAGTATCTCAGATTGACC
ATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACTGAAGTGCTCACTACTCA
GTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAGTCTGTAAATATGTTAAT
GAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTAATAGTACCTAAAATTGC

>56756_56756_10_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369985_SENP6_chr6_76421044_ENST00000370010_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_11_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369985_SENP6_chr6_76421044_ENST00000370014_length(transcript)=3585nt_BP=379nt
GGGGACTCGGCGGGGCGCCGGCCGGCGGGCGGAGACCGACTCGGGATCTGTCCGAGCAGGAAGCCAGCCTCAGCCCGGCCGCTGTCGCCG
CCCTGTCCTGGTGCCCGTCCGCGTCGTCGCCCTCTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCTTCACCCGTACAGGTAGC
CCCGCCGCCGCGCACCTGCCTTCGCTCCCGCACCGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCTCCTTCAAAAATGGAGGA
TGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGACAGCTTAACAATTGAACC
CTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATAGGACAGTGGCATTTAAA
GCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTCAAAATTTTAAGAGAGTA
TTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAATCCAAAAGTACCACAGCA
AAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGTTTTGAACTACCTATGAA
TTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTACAGGAAGATCAGAGCAA
AGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAATAGTATCTCAGATTGACC
ATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACTGAAGTGCTCACTACTCA
GTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAGTCTGTAAATATGTTAAT
GAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTAATAGTACCTAAAATTGC
AACTTCTAAACACAAATAAAAAGAAAATATTTATAGGAGGAAATGATTAATTTGATATTCTTTAGTGAACTTGTTTAATTCCTCAGTGGG
TGTGACATATTTCATGGGAATATTCAAATATCTATGGTAATATTTTGACCCTTTATATTTGTTCTAAAATAAGTCAAAATGTGAAAATAA
TATTAAATCTAAGATATTTTGAACTAAGCATCTTTATATGCTTGTGTAACAGGAACAAAGTAACAGCCTTTCAATTCATATACTGCCTTG
TGTTCAGTGAACCCAAGAAATGTAATAAATATTTGTAATTTTACACAAATATTTAAGAGGAAAGAGTATTAAGAGCAATTCAAAAAAAGT
AACCTTATACTACTAAAAAAAAAATTCTTGCATATATTATCATCAAATGCATTTTTGAAGACATCAAAGACTCAGGTTAAAACTATTTTG
GTAAGTGCAGCTTGAATTTCAAATATCCCGTGTTACCTTTCTCTATTACAGCTTAAAGTATGCTACAATCTGTGTCATATAGTTAATTGA
TAAGCATTTTTAATCTGTGTAAACACAGGAATTTAAATAGGAATTTACTATTTTTTTATAAAGCTTTTGCTATTTTTTCATTGCTCATTT
TGTTCTTATTATTTTGATAAAGTATCAGACTTTTTGCTTGAGTTCTTCAGTGTAAATTATTTTTTACATGTAAAAGTACTGTATTCAACC
AGTTGCATAATACAGCAAAAATCTTTGAATTCCCCTTTAAAATAACTAAAATTTGATGGTTTCCATGACAGATTTATAGCACATATAGGG
ATCTTGCATGTATCTGCAGAAACTTCATTATTTTTCAAATGAAATGGTGTATACTTCTTTCAAATGAACTTTGAGACTTGAAACATATTT
TAGTCATTTTTTGTTAAATATTGAATTTTTAAATACACATATATCAAAAATAGTTGAGAATAAAAAGAAAGCCTAATCATCAGCAATTAT
TTTATTTTTAATTTGGCCATCTCTGACATTGCAGTCAATATCTTAGGGTATTTTCTTGAATTTAATAAAGTCCCATGGGTGGGTTCAGGG
TGAATGGGAGTATTAACAACAACCAAAAAATATCTATTGAGACACAGTAGAGTCTCAGTAAGAGAAATATTAAAATGTAAGAAAGGTCAC
CATTAGTGATATCAACTGTAGTTTGTTACTTTGAACTATATTTCTGATTAACTCTTTATAGTAATAACTTAGAGCTGTTAGCTCAGATAT
CTTAATTAGCTCATATGAAAAACAAGTTTAATTTTATTATTTACTGAACATGGCAAAATGCTTTTCAATCTATAATAAAACTGGGATAAA
AAATTGAAGTTGTTTTTTTTAAAACCTAATAGCAATAAGCAAAATTGGCATACATAATTTTTTTAATGAACTATATTTTGTCAGAATCTG
AAGGTACTGAAAAACTATTCTAAAATGCCTACTTGTTTTTGCATTAATTTGTAATGCTTACATTTTGCACCCTTAGATAATGTTTGATAA
GATAAAAATATAATTTATCCCTTGTACCAACTCAAGTCAATCAGATTTTAACATGAAAAATATAGATTAATGTATGTCAGCTTTCTAGAG
GTAGAATACTCAGCTATTTGATGGCATTTTTCCCACCCCATGTGAAATTTTATTTTTGGAAGTTATGCTAGTGACATTGCAATATATATT
GAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAAAACTAGACTTGAGAATCTTTCGTGTATATGCACATTCACTTGATAATTGTGTATTCT
ATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAATGTGTTATTAGTACTTAGAAGTTGTAAAACAGAACTTATAGAGGTTTGTTACTAGAC
ACTGAAACTGCATGACAAGTATCTGGTGTCTTAACTAATTAGATAGATCTGTTGTATTGGTTTTCTTGTTGGATAGAATAACAGTTAATC
ATTTTTAGAAGAGTTTTAGATTACTTGCCATAAAATTTGTATGTCTCAGCTCTTGTTGGTTTAGGAGCAGAAGTGGTGTTTAGTCCCTTC
CCGTTAATGTTGCTGTGCTACTTCAGACAGCTGAAAACTTAATGGTATTATTTCAAGTTCACATAACCCTAAAAAAGGTTTTCTTTGTGT
AGTAACTTGTGCTTAAACTTTTAGTCAATTAAATGTAGGAGGTTTTATTTGAAAACATAAAATGATTCTCTAAATTACATCTTGTTTTAA
GCCACCAAAATGAATGCAGTAATTTTTCTTTAAAAAAATGATCTCTGAAAACTGTGAGACAATGTAAAAAGAATAAGTTTTAATTCCCCC

>56756_56756_11_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369985_SENP6_chr6_76421044_ENST00000370014_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

--------------------------------------------------------------
>56756_56756_12_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369985_SENP6_chr6_76421044_ENST00000447266_length(transcript)=3582nt_BP=379nt
GGGGACTCGGCGGGGCGCCGGCCGGCGGGCGGAGACCGACTCGGGATCTGTCCGAGCAGGAAGCCAGCCTCAGCCCGGCCGCTGTCGCCG
CCCTGTCCTGGTGCCCGTCCGCGTCGTCGCCCTCTTCACTGGCCCTCATCACTTCTCACCGCGCCCTCCAGCTTCACCCGTACAGGTAGC
CCCGCCGCCGCGCACCTGCCTTCGCTCCCGCACCGGTGACAGTGGATAGTGGAAACAGGAGATCGTGGATCCTCCTTCAAAAATGGAGGA
TGGAAAGCCCGTTTGGGCGCCACACCCTACAGATGGATTTCAGATGGGCAATATTGTGGATATTGGCCCCGACAGCTTAACAATTGAACC
CTTGAATCAGAAAGGCAAGGATGATAGCAGTGACGATGGATTCCTCGCTGATGACAACTGCAGTTCAGAAATAGGACAGTGGCATTTAAA
GCCTACTATCTGTAAACAACCTTGTATCCTACTTATGGACTCACTCCGAGGCCCTTCTCGGTCAAATGTTGTCAAAATTTTAAGAGAGTA
TTTAGAAGTGGAATGGGAAGTTAAAAAAGGAAGCAAAAGAAGTTTTTCCAAAGATGTTATGAAGGGCTCTAATCCAAAAGTACCACAGCA
AAACAACTTCAGTGACTGTGGTGTATATGTATTGCAGTATGTAGAGAGCTTTTTTGAGAATCCAATTCTCAGTTTTGAACTACCTATGAA
TTTGGCAAACTGGTTTCCTCCACCAAGAATGAGAACAAAAAGAGAAGAAATCCGAAACATAATTCTGAAGCTACAGGAAGATCAGAGCAA
AGAGAAAAGAAAGCATAAGGACACTTACTCAACAGAAGCACCTTTAGGCGAAGGAACAGAACAATATGTCAATAGTATCTCAGATTGACC
ATTTCTGTTACTTGTCATTTCTACTTTCAGAAACTAAATGACTTTCAAATTTGGGTATAGACAATAAAGAACTGAAGTGCTCACTACTCA
GTGATTTGGAAATTTTGATGCTTGTATAAATGTCAGATAATTAATTTCCAAAGGCGTATGTATTAAGTAAAAGTCTGTAAATATGTTAAT
GAGGCCAATTTTTCCAGCATTTATAATTATTTTTTTCACTTGTTAGGAAGCTTTTGTTATGTATTTTCTGTTAATAGTACCTAAAATTGC
AACTTCTAAACACAAATAAAAAGAAAATATTTATAGGAGGAAATGATTAATTTGATATTCTTTAGTGAACTTGTTTAATTCCTCAGTGGG
TGTGACATATTTCATGGGAATATTCAAATATCTATGGTAATATTTTGACCCTTTATATTTGTTCTAAAATAAGTCAAAATGTGAAAATAA
TATTAAATCTAAGATATTTTGAACTAAGCATCTTTATATGCTTGTGTAACAGGAACAAAGTAACAGCCTTTCAATTCATATACTGCCTTG
TGTTCAGTGAACCCAAGAAATGTAATAAATATTTGTAATTTTACACAAATATTTAAGAGGAAAGAGTATTAAGAGCAATTCAAAAAAAGT
AACCTTATACTACTAAAAAAAAAATTCTTGCATATATTATCATCAAATGCATTTTTGAAGACATCAAAGACTCAGGTTAAAACTATTTTG
GTAAGTGCAGCTTGAATTTCAAATATCCCGTGTTACCTTTCTCTATTACAGCTTAAAGTATGCTACAATCTGTGTCATATAGTTAATTGA
TAAGCATTTTTAATCTGTGTAAACACAGGAATTTAAATAGGAATTTACTATTTTTTTATAAAGCTTTTGCTATTTTTTCATTGCTCATTT
TGTTCTTATTATTTTGATAAAGTATCAGACTTTTTGCTTGAGTTCTTCAGTGTAAATTATTTTTTACATGTAAAAGTACTGTATTCAACC
AGTTGCATAATACAGCAAAAATCTTTGAATTCCCCTTTAAAATAACTAAAATTTGATGGTTTCCATGACAGATTTATAGCACATATAGGG
ATCTTGCATGTATCTGCAGAAACTTCATTATTTTTCAAATGAAATGGTGTATACTTCTTTCAAATGAACTTTGAGACTTGAAACATATTT
TAGTCATTTTTTGTTAAATATTGAATTTTTAAATACACATATATCAAAAATAGTTGAGAATAAAAAGAAAGCCTAATCATCAGCAATTAT
TTTATTTTTAATTTGGCCATCTCTGACATTGCAGTCAATATCTTAGGGTATTTTCTTGAATTTAATAAAGTCCCATGGGTGGGTTCAGGG
TGAATGGGAGTATTAACAACAACCAAAAAATATCTATTGAGACACAGTAGAGTCTCAGTAAGAGAAATATTAAAATGTAAGAAAGGTCAC
CATTAGTGATATCAACTGTAGTTTGTTACTTTGAACTATATTTCTGATTAACTCTTTATAGTAATAACTTAGAGCTGTTAGCTCAGATAT
CTTAATTAGCTCATATGAAAAACAAGTTTAATTTTATTATTTACTGAACATGGCAAAATGCTTTTCAATCTATAATAAAACTGGGATAAA
AAATTGAAGTTGTTTTTTTTAAAACCTAATAGCAATAAGCAAAATTGGCATACATAATTTTTTTAATGAACTATATTTTGTCAGAATCTG
AAGGTACTGAAAAACTATTCTAAAATGCCTACTTGTTTTTGCATTAATTTGTAATGCTTACATTTTGCACCCTTAGATAATGTTTGATAA
GATAAAAATATAATTTATCCCTTGTACCAACTCAAGTCAATCAGATTTTAACATGAAAAATATAGATTAATGTATGTCAGCTTTCTAGAG
GTAGAATACTCAGCTATTTGATGGCATTTTTCCCACCCCATGTGAAATTTTATTTTTGGAAGTTATGCTAGTGACATTGCAATATATATT
GAAATCTTCGGAGGCTGCCAGGTTGAGCTTCAAAACTAGACTTGAGAATCTTTCGTGTATATGCACATTCACTTGATAATTGTGTATTCT
ATGTAGTTTAAAGTGGGATCAAGCCTTTTAAAATGTGTTATTAGTACTTAGAAGTTGTAAAACAGAACTTATAGAGGTTTGTTACTAGAC
ACTGAAACTGCATGACAAGTATCTGGTGTCTTAACTAATTAGATAGATCTGTTGTATTGGTTTTCTTGTTGGATAGAATAACAGTTAATC
ATTTTTAGAAGAGTTTTAGATTACTTGCCATAAAATTTGTATGTCTCAGCTCTTGTTGGTTTAGGAGCAGAAGTGGTGTTTAGTCCCTTC
CCGTTAATGTTGCTGTGCTACTTCAGACAGCTGAAAACTTAATGGTATTATTTCAAGTTCACATAACCCTAAAAAAGGTTTTCTTTGTGT
AGTAACTTGTGCTTAAACTTTTAGTCAATTAAATGTAGGAGGTTTTATTTGAAAACATAAAATGATTCTCTAAATTACATCTTGTTTTAA
GCCACCAAAATGAATGCAGTAATTTTTCTTTAAAAAAATGATCTCTGAAAACTGTGAGACAATGTAAAAAGAATAAGTTTTAATTCCCCC

>56756_56756_12_MYO6-SENP6_MYO6_chr6_76527381_ENST00000369985_SENP6_chr6_76421044_ENST00000447266_length(amino acids)=211AA_BP=39
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKIL
REYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQED

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Fusion Gene PPI Analysis for MYO6-SENP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMYO6chr6:76527381chr6:76421044ENST00000369977-2351116_111839.01286.0OPTN
HgeneMYO6chr6:76527381chr6:76421044ENST00000369985-2331116_111839.01263.0OPTN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO6-SENP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO6-SENP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource