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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:MYO7A-ZNF512 (FusionGDB2 ID:56760)

Fusion Gene Summary for MYO7A-ZNF512

Fusion gene summary

Fusion gene information	Fusion gene name: MYO7A-ZNF512
	Fusion gene ID: 56760
		Hgene	Tgene
	Gene symbol	MYO7A	ZNF512
	Gene ID	4647	84450
	Gene name	myosin VIIA	zinc finger protein 512
	Synonyms	DFNA11\|DFNB2\|MYOVIIA\|MYU7A\|NSRD2\|USH1B	-
	Cytomap	11q13.5	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-VIIamyosin VIIA (Usher syndrome 1B (autosomal recessive, severe))	zinc finger protein 512
	Modification date	20200313	20200313
	UniProtAcc	Q13402	.
	Ensembl transtripts involved in fusion gene	ENST00000409619, ENST00000409709, ENST00000458637, ENST00000409893, ENST00000605744,	ENST00000413371, ENST00000416005, ENST00000494548, ENST00000556601, ENST00000355467, ENST00000379717,
Fusion gene scores	* DoF score	3 X 3 X 3=27	9 X 9 X 7=567
	# samples	3	10
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(10/567*10)=-2.5033487351675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MYO7A [Title/Abstract] AND ZNF512 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MYO7A(76913469)-ZNF512(27844020), # samples:2
Anticipated loss of major functional domain due to fusion event.	MYO7A-ZNF512 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MYO7A-ZNF512 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. MYO7A-ZNF512 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MYO7A	GO:0007040	lysosome organization	16001398
Hgene	MYO7A	GO:0030048	actin filament-based movement	21687988

Fusion gene breakpoints across MYO7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF512 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N9-A4Q1-01A	MYO7A	chr11	76913469	-	ZNF512	chr2	27844020	+
ChimerDB4	UCS	TCGA-N9-A4Q1-01A	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+

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Fusion Gene ORF analysis for MYO7A-ZNF512

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000409619	ENST00000413371	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000409619	ENST00000416005	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000409619	ENST00000494548	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000409619	ENST00000556601	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000409709	ENST00000413371	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000409709	ENST00000416005	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000409709	ENST00000494548	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000409709	ENST00000556601	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000458637	ENST00000413371	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000458637	ENST00000416005	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000458637	ENST00000494548	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
5CDS-intron	ENST00000458637	ENST00000556601	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
Frame-shift	ENST00000409619	ENST00000355467	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
Frame-shift	ENST00000409709	ENST00000355467	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
Frame-shift	ENST00000458637	ENST00000355467	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
In-frame	ENST00000409619	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
In-frame	ENST00000409709	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
In-frame	ENST00000458637	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-3CDS	ENST00000409893	ENST00000355467	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-3CDS	ENST00000409893	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-3CDS	ENST00000605744	ENST00000355467	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-3CDS	ENST00000605744	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000409893	ENST00000413371	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000409893	ENST00000416005	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000409893	ENST00000494548	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000409893	ENST00000556601	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000605744	ENST00000413371	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000605744	ENST00000416005	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000605744	ENST00000494548	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+
intron-intron	ENST00000605744	ENST00000556601	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000409709

MYO7A

chr11

76913469

ENST00000379717

ZNF512

chr2

27844020

7382

5440

272

5455

1727

ENST00000458637

MYO7A

chr11

76913469

ENST00000379717

ZNF512

chr2

27844020

7262

5320

266

5335

1689

ENST00000409619

MYO7A

chr11

76913469

ENST00000379717

ZNF512

chr2

27844020

7310

5368

221

5383

1720

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409709	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+	0.004197273	0.9958027
ENST00000458637	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+	0.002538347	0.9974617
ENST00000409619	ENST00000379717	MYO7A	chr11	76913469	+	ZNF512	chr2	27844020	+	0.002589427	0.9974106

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Fusion Genomic Features for MYO7A-ZNF512

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO7A-ZNF512

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:76913469/chr2:27844020)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYO7A Q13402	.
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000250, ECO:0000269\|PubMed:19643958, ECO:0000269\|PubMed:21493626, ECO:0000269\|PubMed:21687988, ECO:0000269\|PubMed:21709241}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

1017_1253

1722

2216.0

Domain

MyTH4 1

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

1258_1602

1722

2216.0

Domain

FERM 1

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

1603_1672

1722

2216.0

Domain

SH3

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

65_741

1722

2216.0

Domain

Myosin motor

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

745_765

1722

2216.0

Domain

IQ 1

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

768_788

1722

2216.0

Domain

IQ 2

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

791_811

1722

2216.0

Domain

IQ 3

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

814_834

1722

2216.0

Domain

IQ 4

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

837_857

1722

2216.0

Domain

IQ 5

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

1017_1253

1684

2176.0

Domain

MyTH4 1

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

1258_1602

1684

2176.0

Domain

FERM 1

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

1603_1672

1684

2176.0

Domain

SH3

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

65_741

1684

2176.0

Domain

Myosin motor

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

745_765

1684

2176.0

Domain

IQ 1

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

768_788

1684

2176.0

Domain

IQ 2

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

791_811

1684

2176.0

Domain

IQ 3

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

814_834

1684

2176.0

Domain

IQ 4

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

837_857

1684

2176.0

Domain

IQ 5

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

158_165

1722

2216.0

Nucleotide binding

ATP

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

158_165

1684

2176.0

Nucleotide binding

ATP

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

632_639

1722

2216.0

Region

Actin-binding

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

858_935

1722

2216.0

Region

SAH

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

632_639

1684

2176.0

Region

Actin-binding

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

858_935

1684

2176.0

Region

SAH

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000413371

406_430

388

491.0

Zinc finger

C2H2-type 3%3B atypical

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000413371

440_463

388

491.0

Zinc finger

C2H2-type 4

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000416005

440_463

436

539.0

Zinc finger

C2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

1747_1896

1722

2216.0

Domain

MyTH4 2

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000409709

1902_2205

1722

2216.0

Domain

FERM 2

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

1747_1896

1684

2176.0

Domain

MyTH4 2

Hgene

MYO7A

chr11:76913469

chr2:27844020

ENST00000458637

1902_2205

1684

2176.0

Domain

FERM 2

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000355467

197_220

465

568.0

Zinc finger

C2H2-type 1

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000355467

287_310

465

568.0

Zinc finger

C2H2-type 2

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000355467

406_430

465

568.0

Zinc finger

C2H2-type 3%3B atypical

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000355467

440_463

465

568.0

Zinc finger

C2H2-type 4

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000413371

197_220

388

491.0

Zinc finger

C2H2-type 1

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000413371

287_310

388

491.0

Zinc finger

C2H2-type 2

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000416005

197_220

436

539.0

Zinc finger

C2H2-type 1

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000416005

287_310

436

539.0

Zinc finger

C2H2-type 2

Tgene

ZNF512

chr11:76913469

chr2:27844020

ENST00000416005

406_430

436

539.0

Zinc finger

C2H2-type 3%3B atypical

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Fusion Gene Sequence for MYO7A-ZNF512

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>56760_56760_1_MYO7A-ZNF512_MYO7A_chr11_76913469_ENST00000409619_ZNF512_chr2_27844020_ENST00000379717_length(transcript)=7310nt_BP=5368nt
CACAGAGAGACGGCGAGGAAGGGAAAGACCCAGAGGGACGCCTAGAACGAGACTTGGAGCCAGACAGAGGAAGAGGGGACGTGTGTTTGC
AGACTGGCTGGGCCCGTGACCCAGCTTCCTGAGTCCTCCGTGCAGGTGGCAGCTGTACCAGGCTGGCAGGTCACTGAGAGTGGGCAGCTG
GGCCCCAGAACTGTGCCTGGCCCAGTGGGCAGCAGGAGCTCCTGACTTGGGACCATGGTGATTCTTCAGCAGGAGAAAAGCTGGGACTTG
CCCCACGTTACACAGCCACACTGAGGCATGTGTCGTGTCACAAACGAGATCTTCCATTCAAGGGGGACCATGTGTGGATGGACCTGAGAT
TGGGGCAGGAGTTCGACGTGCCCATCGGGGCGGTGGTGAAGCTCTGCGACTCTGGGCAGGTCCAGGTGGTGGATGATGAAGACAATGAAC
ACTGGATCTCTCCGCAGAACGCAACGCACATCAAGCCTATGCACCCCACGTCGGTCCACGGCGTGGAGGACATGATCCGCCTGGGGGACC
TCAACGAGGCGGGCATCTTGCGCAACCTGCTTATCCGCTACCGGGACCACCTCATCTACACGTATACGGGCTCCATCCTGGTGGCTGTGA
ACCCCTACCAGCTGCTCTCCATCTACTCGCCAGAGCACATCCGCCAGTATACCAACAAGAAGATTGGGGAGATGCCCCCCCACATCTTTG
CCATTGCTGACAACTGCTACTTCAACATGAAACGCAACAGCCGAGACCAGTGCTGCATCATCAGTGGGGAATCTGGGGCCGGGAAGACGG
AGAGCACAAAGCTGATCCTGCAGTTCCTGGCAGCCATCAGTGGGCAGCACTCGTGGATTGAGCAGCAGGTCTTGGAGGCCACCCCCATTC
TGGAAGCATTTGGGAATGCCAAGACCATCCGCAATGACAACTCAAGCCGTTTCGGAAAGTACATCGACATCCACTTCAACAAGCGGGGCG
CCATCGAGGGCGCGAAGATTGAGCAGTACCTGCTGGAAAAGTCACGTGTCTGTCGCCAGGCCCTGGATGAAAGGAACTACCACGTGTTCT
ACTGCATGCTGGAGGGTATGAGTGAGGATCAGAAGAAGAAGCTGGGCTTGGGCCAGGCCTCTGACTACAACTACTTGGCCATGGGTAACT
GCATAACCTGTGAGGGCCGGGTGGACAGCCAGGAGTACGCCAACATCCGCTCCGCCATGAAGGTGCTCATGTTCACTGACACCGAGAACT
GGGAGATCTCGAAGCTCCTGGCTGCCATCCTGCACCTGGGCAACCTGCAGTATGAGGCACGCACATTTGAAAACCTGGATGCCTGTGAGG
TTCTCTTCTCCCCATCGCTGGCCACAGCTGCATCCCTGCTTGAGGTGAACCCCCCAGACCTGATGAGCTGCCTGACTAGCCGCACCCTCA
TCACCCGCGGGGAGACGGTGTCCACCCCACTGAGCAGGGAACAGGCACTGGACGTGCGCGACGCCTTCGTAAAGGGGATCTACGGGCGGC
TGTTCGTGTGGATTGTGGACAAGATCAACGCAGCAATTTACAAGCCTCCCTCCCAGGATGTGAAGAACTCTCGCAGGTCCATCGGCCTCC
TGGACATCTTTGGGTTTGAGAACTTTGCTGTGAACAGCTTTGAGCAGCTCTGCATCAACTTCGCCAATGAGCACCTGCAGCAGTTCTTTG
TGCGGCACGTGTTCAAGCTGGAGCAGGAGGAATATGACCTGGAGAGCATTGACTGGCTGCACATCGAGTTCACTGACAACCAGGATGCCC
TGGACATGATTGCCAACAAGCCCATGAACATCATCTCCCTCATCGATGAGGAGAGCAAGTTCCCCAAGGGCACAGACACCACCATGTTAC
ACAAGCTGAACTCCCAGCACAAGCTCAACGCCAACTACATCCCCCCCAAGAACAACCATGAGACCCAGTTTGGCATCAACCATTTTGCAG
GCATCGTCTACTATGAGACCCAAGGCTTCCTGGAGAAGAACCGAGACACCCTGCATGGGGACATTATCCAGCTGGTCCACTCCTCCAGGA
ACAAGTTCATCAAGCAGATCTTCCAGGCCGATGTCGCCATGGGCGCCGAGACCAGGAAGCGCTCGCCCACACTTAGCAGCCAGTTCAAGC
GGTCACTGGAGCTGCTGATGCGCACGCTGGGTGCCTGCCAGCCCTTCTTTGTGCGATGCATCAAGCCCAATGAGTTCAAGAAGCCCATGC
TGTTCGACCGGCACCTGTGCGTGCGCCAGCTGCGGTACTCAGGAATGATGGAGACCATCCGAATCCGCCGAGCTGGCTACCCCATCCGCT
ACAGCTTCGTAGAGTTTGTGGAGCGGTACCGTGTGCTGCTGCCAGGTGTGAAGCCGGCCTACAAGCAGGGCGACCTCCGCGGGACTTGCC
AGCGCATGGCTGAGGCTGTGCTGGGCACCCACGATGACTGGCAGATAGGCAAAACCAAGATCTTTCTGAAGGACCACCATGACATGCTGC
TGGAAGTGGAGCGGGACAAAGCCATCACCGACAGAGTCATCCTCCTTCAGAAAGTCATCCGGGGATTCAAAGACAGGTCTAACTTTCTGA
AGCTGAAGAACGCTGCCACACTGATCCAGAGGCACTGGCGGGGTCACAACTGTAGGAAGAACTACGGGCTGATGCGTCTGGGCTTCCTGC
GGCTGCAGGCCCTGCACCGCTCCCGGAAGCTGCACCAGCAGTACCGCCTGGCCCGCCAGCGCATCATCCAGTTCCAGGCCCGCTGCCGCG
CCTATCTGGTGCGCAAGGCCTTCCGCCACCGCCTCTGGGCTGTGCTCACCGTGCAGGCCTATGCCCGGGGCATGATCGCCCGCAGGCTGC
ACCAACGCCTCAGGGCTGAGTATCTGTGGCGCCTCGAGGCTGAGAAAATGCGGCTGGCGGAGGAAGAGAAGCTTCGGAAGGAGATGAGCG
CCAAGAAGGCCAAGGAGGAGGCCGAGCGCAAGCATCAGGAGCGCCTGGCCCAGCTGGCTCGTGAGGACGCTGAGCGGGAGCTGAAGGAGA
AGGAGGCCGCTCGGCGGAAGAAGGAGCTCCTGGAGCAGATGGAAAGGGCCCGCCATGAGCCTGTCAATCACTCAGACATGGTGGACAAGA
TGTTTGGCTTCCTGGGGACTTCAGGTGGCCTGCCAGGCCAGGAGGGCCAGGCACCTAGTGGCTTTGAGGACCTGGAGCGAGGGCGGAGGG
AGATGGTGGAGGAGGACCTGGATGCAGCCCTGCCCCTGCCTGACGAGGATGAGGAGGACCTCTCTGAGTATAAATTTGCCAAGTTCGCGG
CCACCTACTTCCAGGGGACAACCACGCACTCCTACACCCGGCGGCCACTCAAACAGCCACTGCTCTACCATGACGACGAGGGTGACCAGC
TGGCAGCCCTGGCGGTCTGGATCACCATCCTCCGCTTCATGGGGGACCTCCCTGAGCCCAAGTACCACACAGCCATGAGTGATGGCAGTG
AGAAGATCCCTGTGATGACCAAGATTTATGAGACCCTGGGCAAGAAGACGTACAAGAGGGAGCTGCAGGCCCTGCAGGGCGAGGGCGAGG
CCCAGCTCCCCGAGGGCCAGAAGAAGAGCAGTGTGAGGCACAAGCTGGTGCATTTGACTCTGAAAAAGAAGTCCAAGCTCACAGAGGAGG
TGACCAAGAGGCTGCATGACGGGGAGTCCACAGTGCAGGGCAACAGCATGCTGGAGGACCGGCCCACCTCCAACCTGGAGAAGCTGCACT
TCATCATCGGCAATGGCATCCTGCGGCCAGCACTCCGGGACGAGATCTACTGCCAGATCAGCAAGCAGCTGACCCACAACCCCTCCAAGA
GCAGCTATGCCCGGGGCTGGATTCTCGTGTCTCTCTGCGTGGGCTGTTTCGCCCCCTCCGAGAAGTTTGTCAAGTACCTGCGGAACTTCA
TCCACGGGGGCCCGCCCGGCTACGCCCCGTACTGTGAGGAGCGCCTGAGAAGGACCTTTGTCAATGGGACACGGACACAGCCGCCCAGCT
GGCTGGAGCTGCAGGCCACCAAGTCCAAGAAGCCAATCATGTTGCCCGTGACATTCATGGATGGGACCACCAAGACCCTGCTGACGGACT
CGGCAACCACGGCCAAGGAGCTCTGCAACGCGCTGGCCGACAAGATCTCTCTCAAGGACCGGTTCGGGTTCTCCCTCTACATTGCCCTGT
TTGACAAGGTGTCCTCCCTGGGCAGCGGCAGTGACCACGTCATGGACGCCATCTCCCAGTGCGAGCAGTACGCCAAGGAGCAGGGCGCCC
AGGAGCGCAACGCCCCCTGGAGGCTCTTCTTCCGCAAAGAGGTCTTCACGCCCTGGCACAGCCCCTCCGAGGACAACGTGGCCACCAACC
TCATCTACCAGCAGGTGGTGCGAGGAGTCAAGTTTGGGGAGTACAGGTGTGAGAAGGAGGACGACCTGGCTGAGCTGGCCTCCCAGCAGT
ACTTTGTAGACTATGGCTCTGAGATGATCCTGGAGCGCCTCCTGAACCTCGTGCCCACCTACATCCCCGACCGCGAGATCACGCCCCTGA
AGACGCTGGAGAAGTGGGCCCAGCTGGCCATCGCCGCCCACAAGAAGGGGATTTATGCCCAGAGGAGAACTGATGCCCAGAAGGTCAAAG
AGGATGTGGTCAGTTATGCCCGCTTCAAGTGGCCCTTGCTCTTCTCCAGGTTTTATGAAGCCTACAAATTCTCAGGCCCCAGTCTCCCCA
AGAACGACGTCATCGTGGCCGTCAACTGGACGGGTGTGTACTTTGTGGATGAGCAGGAGCAGGTACTTCTGGAGCTGTCCTTCCCAGAGA
TCATGGCCGTGTCCAGCAGCAGGGGAGCGAAAACGACGGCCCCCAGCTTCACGCTGGCCACCATCAAGGGGGACGAATACACCTTCACCT
CCAGCAATGCTGAGGACATTCGTGACCTGGTGGTCACCTTCCTAGAGGGGCTCCGGAAGAGATCTAAGTATGTTGTGGCCCTGCAGGATA
ACCCCAACCCCGCAGGCGAGGAGTCAGGCTTCCTCAGCTTTGCCAAGGGAGACCTCATCATCCTGGACCATGACACGGGCGAGCAGGTCA
TGAACTCGGGCTGGGCCAACGGCATCAATGAGAGGACCAAGCAGCGTGGGGACTTCCCCACCGACAGTGTGTACGTCATGCCCACTGTCA
CCATGCCACCGCGGGAGATTGTGGCCCTGGTCACCATGACTCCCGATCAGAGGCAGGACGTTGTCCGGCTCTTGCAGCTGCGAACGGCGG
AGCCCGAGGTGCGTGCCAAGCCCTACACGCTGGAGGAGTTTTCCTATGACTACTTCAGGACTGGTTCGTTGTAAACCCAACAACAACCAA
AAGCTTTGAAAAGCTGATGAAGATAAAGCAGCGGCAGCAAGAAGAAGAAAAGCGGAGGCAGCAGCACAGGAGCAGAAGGTCTCTAAGAAG
GCGGCAGCAGCCTGGCATTGAGCTTCCCGAGACAGAGCTGAGTCTTAGAGTAGGGAAGGATCAGAGGAGGAATAATGAGGAACTGGTAGT
GTCAGCCTCCTGTAAGGAACCAGAGCAGGAGCCAGTGCCAGCACAGTTCCAGAAAGTAAAGCCCCCAAAGACTAATCATAAACGAGGAAG
GAAATAGGCAGTCAGTGTAAAAGTGCTCCTAGGAAAGCAGATGTGATGCTGTTGTCACGGGGACCTGTGCTGGGAGGACTGAGTGAAGAT
TCTTTCAGCTGTTTGTGTAAGGCTGTGACTTTCTCAGCTCCTTCCTCCTGTGTAAATTTCACTGTCTTCCCTTCTTACATTTTGATTCCC
CCCTCCCCTTTTAGTAGGTTTTCCTGCTATTCCTCGTCAAGTCCTCTTGTTTTTTTATCTTGCCCAAAGAGCTCCCTCTCAAGGCCAACT
ATAGGCTCCTCTTGCCCTGTACAAAACTAAGAAACCTCTTTGGTTGTCCTTTCCTTCCTGGGGTATAGAATGTTCTTGGAAGCTCCATTG
ATTTAGTAGCTGCTCCATCATCTAGCTTGTGAAACCATTCCAAACTAATTTTTTAAAACCATAACTGATTTGTCATTTTGTATTTGTGAT
ATAACAAGTCTAGAAGTTAGAACTGTTGTCATTCACATAATAAGATTACTCTGTCTCCTTGGGAAAAAAACTTTATGGAGGCTGTTTGTC
CTCTCAATATGGTTTTAAGATTGAAAGTAAGAAAACGGATTTAGGATGAAAACTCTAGAACTACCCTATGCTGTTTATACTGGGAAATGC
TTTGTACCAAGTAGCAGTGACTAGACCCACAGACATGAAAAGCAACCTTAGGAGTAAAGTGACCCAAACATTAAAATGACAGGAAAGAGA
AAGTAGAAGCAGCAATAAATACTGCCCCAACTTTCCTGGAGCCCGAGGCCTCATCCATAGCTATGATCACTTGCCCTCTGAAGCTTATTT
TTGCTTCTTTGGTTTTAAGAATTGAGAAATATCACATTGCCCCTGATGTTTTGACAGTCTCCTAGTGCTCCTGGTAGTGCCACTAAGGGA
AAACCAAGGTGCGCATTCCTTCTCCCTGGACTTTACCTTACTTGTTAGTCTACGCCCCACTGTTTCCACCCATCCCCTTAGCCAACCTCT
GTCTTTTTGAATTTTCTGAGAATATTGTCCTATCCTCTTTTATATATGGAGTTCTCTCCTCTTTATATCCTGAGACTTTGACACCAGATG
TAGATATTTATCTGGAGCTGGAAAGAAAAATTCTTTTTCTGTACCTCATGCCTATCTGGTAATGTTTAATGGGTTATTTCTCTTTGAGGG
TGGCTTTCTCTGGAACATTGGTTAGAGCAGCTTTGTTGTCGTGTTTCTGGATTCTCTTCCCCATTTTGCGTAAATATTGGTCTTATATAT
TCTTGCCTATTTTGTGGCATATGCCACATAAAAAATGAACCTGATATAGACAAGTACTACCTTTTCAAATTCTGAAAGGCTATTACCACT
TTAACTCTTTGTGCTCCTCCAAATAGCTTTAAAATGTGGGCTTTTGTGAAGACCACTTTCAAACAAGGGAGCACTGAAACCTGAATTGGA
TACTGCCAGAATAGGTAGTTTTGAAACAAGTTAAGGACATGGTATATGCACTCTGCATTTTCATTGGCAGTGTGCCCTTAAAGCCCTTTC
AGTAGATGAGGGTTGTCAGGGAGGAGAAATGAAGAAGCTATGTTAATTTCTGGTGAGTAAGACCTGGGGAATGTTTGGCAATGACAAAAG

>56760_56760_1_MYO7A-ZNF512_MYO7A_chr11_76913469_ENST00000409619_ZNF512_chr2_27844020_ENST00000379717_length(amino acids)=1720AA_BP=
MTWDHGDSSAGEKLGLAPRYTATLRHVSCHKRDLPFKGDHVWMDLRLGQEFDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQNATHIKPM
HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNS
RDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEK
SRVCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLAAILHLG
NLQYEARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIY
KPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISL
IDEESKFPKGTDTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAM
GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLL
PGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHWR
GHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEA
EKMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEAARRKKELLEQMERARHEPVNHSDMVDKMFGFLGTSGGLPGQ
EGQAPSGFEDLERGRREMVEEDLDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFM
GDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHDGESTVQG
NSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEE
RLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHV
MDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERL
LNLVPTYIPDREITPLKTLEKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVY
FVDEQEQVLLELSFPEIMAVSSSRGAKTTAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSF
AKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDSVYVMPTVTMPPREIVALVTMTPDQRQDVVRLLQLRTAEPEVRAKPYTLEEF

--------------------------------------------------------------
>56760_56760_2_MYO7A-ZNF512_MYO7A_chr11_76913469_ENST00000409709_ZNF512_chr2_27844020_ENST00000379717_length(transcript)=7382nt_BP=5440nt
GCTCTGGGCAGGAGAGAGAGGGAGAGACAAGAGACACACACAGAGAGACGGCGAGGAAGGGAAAGACCCAGAGGGACGCCTAGAACGAGA
CTTGGAGCCAGACAGAGGAAGAGGGGACGTGTGTTTGCAGACTGGCTGGGCCCGTGACCCAGCTTCCTGAGTCCTCCGTGCAGGTGGCAG
CTGTACCAGGCTGGCAGGTCACTGAGAGTGGGCAGCTGGGCCCCAGAACTGTGCCTGGCCCAGTGGGCAGCAGGAGCTCCTGACTTGGGA
CCATGGTGATTCTTCAGCAGGGGGACCATGTGTGGATGGACCTGAGATTGGGGCAGGAGTTCGACGTGCCCATCGGGGCGGTGGTGAAGC
TCTGCGACTCTGGGCAGGTCCAGGTGGTGGATGATGAAGACAATGAACACTGGATCTCTCCGCAGAACGCAACGCACATCAAGCCTATGC
ACCCCACGTCGGTCCACGGCGTGGAGGACATGATCCGCCTGGGGGACCTCAACGAGGCGGGCATCTTGCGCAACCTGCTTATCCGCTACC
GGGACCACCTCATCTACACGTATACGGGCTCCATCCTGGTGGCTGTGAACCCCTACCAGCTGCTCTCCATCTACTCGCCAGAGCACATCC
GCCAGTATACCAACAAGAAGATTGGGGAGATGCCCCCCCACATCTTTGCCATTGCTGACAACTGCTACTTCAACATGAAACGCAACAGCC
GAGACCAGTGCTGCATCATCAGTGGGGAATCTGGGGCCGGGAAGACGGAGAGCACAAAGCTGATCCTGCAGTTCCTGGCAGCCATCAGTG
GGCAGCACTCGTGGATTGAGCAGCAGGTCTTGGAGGCCACCCCCATTCTGGAAGCATTTGGGAATGCCAAGACCATCCGCAATGACAACT
CAAGCCGTTTCGGAAAGTACATCGACATCCACTTCAACAAGCGGGGCGCCATCGAGGGCGCGAAGATTGAGCAGTACCTGCTGGAAAAGT
CACGTGTCTGTCGCCAGGCCCTGGATGAAAGGAACTACCACGTGTTCTACTGCATGCTGGAGGGTATGAGTGAGGATCAGAAGAAGAAGC
TGGGCTTGGGCCAGGCCTCTGACTACAACTACTTGGCCATGGGTAACTGCATAACCTGTGAGGGCCGGGTGGACAGCCAGGAGTACGCCA
ACATCCGCTCCGCCATGAAGGTGCTCATGTTCACTGACACCGAGAACTGGGAGATCTCGAAGCTCCTGGCTGCCATCCTGCACCTGGGCA
ACCTGCAGTATGAGGCACGCACATTTGAAAACCTGGATGCCTGTGAGGTTCTCTTCTCCCCATCGCTGGCCACAGCTGCATCCCTGCTTG
AGGTGAACCCCCCAGACCTGATGAGCTGCCTGACTAGCCGCACCCTCATCACCCGCGGGGAGACGGTGTCCACCCCACTGAGCAGGGAAC
AGGCACTGGACGTGCGCGACGCCTTCGTAAAGGGGATCTACGGGCGGCTGTTCGTGTGGATTGTGGACAAGATCAACGCAGCAATTTACA
AGCCTCCCTCCCAGGATGTGAAGAACTCTCGCAGGTCCATCGGCCTCCTGGACATCTTTGGGTTTGAGAACTTTGCTGTGAACAGCTTTG
AGCAGCTCTGCATCAACTTCGCCAATGAGCACCTGCAGCAGTTCTTTGTGCGGCACGTGTTCAAGCTGGAGCAGGAGGAATATGACCTGG
AGAGCATTGACTGGCTGCACATCGAGTTCACTGACAACCAGGATGCCCTGGACATGATTGCCAACAAGCCCATGAACATCATCTCCCTCA
TCGATGAGGAGAGCAAGTTCCCCAAGGGCACAGACACCACCATGTTACACAAGCTGAACTCCCAGCACAAGCTCAACGCCAACTACATCC
CCCCCAAGAACAACCATGAGACCCAGTTTGGCATCAACCATTTTGCAGGCATCGTCTACTATGAGACCCAAGGCTTCCTGGAGAAGAACC
GAGACACCCTGCATGGGGACATTATCCAGCTGGTCCACTCCTCCAGGAACAAGTTCATCAAGCAGATCTTCCAGGCCGATGTCGCCATGG
GCGCCGAGACCAGGAAGCGCTCGCCCACACTTAGCAGCCAGTTCAAGCGGTCACTGGAGCTGCTGATGCGCACGCTGGGTGCCTGCCAGC
CCTTCTTTGTGCGATGCATCAAGCCCAATGAGTTCAAGAAGCCCATGCTGTTCGACCGGCACCTGTGCGTGCGCCAGCTGCGGTACTCAG
GAATGATGGAGACCATCCGAATCCGCCGAGCTGGCTACCCCATCCGCTACAGCTTCGTAGAGTTTGTGGAGCGGTACCGTGTGCTGCTGC
CAGGTGTGAAGCCGGCCTACAAGCAGGGCGACCTCCGCGGGACTTGCCAGCGCATGGCTGAGGCTGTGCTGGGCACCCACGATGACTGGC
AGATAGGCAAAACCAAGATCTTTCTGAAGGACCACCATGACATGCTGCTGGAAGTGGAGCGGGACAAAGCCATCACCGACAGAGTCATCC
TCCTTCAGAAAGTCATCCGGGGATTCAAAGACAGGTCTAACTTTCTGAAGCTGAAGAACGCTGCCACACTGATCCAGAGGCACTGGCGGG
GTCACAACTGTAGGAAGAACTACGGGCTGATGCGTCTGGGCTTCCTGCGGCTGCAGGCCCTGCACCGCTCCCGGAAGCTGCACCAGCAGT
ACCGCCTGGCCCGCCAGCGCATCATCCAGTTCCAGGCCCGCTGCCGCGCCTATCTGGTGCGCAAGGCCTTCCGCCACCGCCTCTGGGCTG
TGCTCACCGTGCAGGCCTATGCCCGGGGCATGATCGCCCGCAGGCTGCACCAACGCCTCAGGGCTGAGTATCTGTGGCGCCTCGAGGCTG
AGAAAATGCGGCTGGCGGAGGAAGAGAAGCTTCGGAAGGAGATGAGCGCCAAGAAGGCCAAGGAGGAGGCCGAGCGCAAGCATCAGGAGC
GCCTGGCCCAGCTGGCTCGTGAGGACGCTGAGCGGGAGCTGAAGGAGAAGGAGGCCGCTCGGCGGAAGAAGGAGCTCCTGGAGCAGATGG
AAAGGGCCCGCCATGAGCCTGTCAATCACTCAGACATGGTGGACAAGATGTTTGGCTTCCTGGGGACTTCAGGTGGCCTGCCAGGCCAGG
AGGGCCAGGCACCTAGTGGCTTTGAGGACCTGGAGCGAGGGCGGAGGGAGATGGTGGAGGAGGACCTGGATGCAGCCCTGCCCCTGCCTG
ACGAGGATGAGGAGGACCTCTCTGAGTATAAATTTGCCAAGTTCGCGGCCACCTACTTCCAGGGGACAACCACGCACTCCTACACCCGGC
GGCCACTCAAACAGCCACTGCTCTACCATGACGACGAGGGTGACCAGCTGGCAGCCCTGGCGGTCTGGATCACCATCCTCCGCTTCATGG
GGGACCTCCCTGAGCCCAAGTACCACACAGCCATGAGTGATGGCAGTGAGAAGATCCCTGTGATGACCAAGATTTATGAGACCCTGGGCA
AGAAGACGTACAAGAGGGAGCTGCAGGCCCTGCAGGGCGAGGGCGAGGCCCAGCTCCCCGAGGGCCAGAAGAAGAGCAGTGTGAGGCACA
AGCTGGTGCATTTGACTCTGAAAAAGAAGTCCAAGCTCACAGAGGAGGTGACCAAGAGGCTGCATGACGGGGAGTCCACAGTGCAGGGCA
ACAGCATGCTGGAGGACCGGCCCACCTCCAACCTGGAGAAGCTGCACTTCATCATCGGCAATGGCATCCTGCGGCCAGCACTCCGGGACG
AGATCTACTGCCAGATCAGCAAGCAGCTGACCCACAACCCCTCCAAGAGCAGCTATGCCCGGGGCTGGATTCTCGTGTCTCTCTGCGTGG
GCTGTTTCGCCCCCTCCGAGAAGTTTGTCAAGTACCTGCGGAACTTCATCCACGGGGGCCCGCCCGGCTACGCCCCGTACTGTGAGGAGC
GCCTGAGAAGGACCTTTGTCAATGGGACACGGACACAGCCGCCCAGCTGGCTGGAGCTGCAGGCCACCAAGTCCAAGAAGCCAATCATGT
TGCCCGTGACATTCATGGATGGGACCACCAAGACCCTGCTGACGGACTCGGCAACCACGGCCAAGGAGCTCTGCAACGCGCTGGCCGACA
AGATCTCTCTCAAGGACCGGTTCGGGTTCTCCCTCTACATTGCCCTGTTTGACAAGGTGTCCTCCCTGGGCAGCGGCAGTGACCACGTCA
TGGACGCCATCTCCCAGTGCGAGCAGTACGCCAAGGAGCAGGGCGCCCAGGAGCGCAACGCCCCCTGGAGGCTCTTCTTCCGCAAAGAGG
TCTTCACGCCCTGGCACAGCCCCTCCGAGGACAACGTGGCCACCAACCTCATCTACCAGCAGGTGGTGCGAGGAGTCAAGTTTGGGGAGT
ACAGGTGTGAGAAGGAGGACGACCTGGCTGAGCTGGCCTCCCAGCAGTACTTTGTAGACTATGGCTCTGAGATGATCCTGGAGCGCCTCC
TGAACCTCGTGCCCACCTACATCCCCGACCGCGAGATCACGCCCCTGAAGACGCTGGAGAAGTGGGCCCAGCTGGCCATCGCCGCCCACA
AGAAGGGGATTTATGCCCAGAGGAGAACTGATGCCCAGAAGGTCAAAGAGGATGTGGTCAGTTATGCCCGCTTCAAGTGGCCCTTGCTCT
TCTCCAGGTTTTATGAAGCCTACAAATTCTCAGGCCCCAGTCTCCCCAAGAACGACGTCATCGTGGCCGTCAACTGGACGGGTGTGTACT
TTGTGGATGAGCAGGAGCAGGTACTTCTGGAGCTGTCCTTCCCAGAGATCATGGCCGTGTCCAGCAGCAGGGAGTGCCGTGTCTGGCTCT
CACTGGGCTGCTCTGATCTTGGCTGTGCTGCGCCTCACTCAGGCTGGGCAGGACTGACCCCGGCGGGGCCCTGTTCTCCGTGTTGGTCCT
GCAGGGGAGCGAAAACGACGGCCCCCAGCTTCACGCTGGCCACCATCAAGGGGGACGAATACACCTTCACCTCCAGCAATGCTGAGGACA
TTCGTGACCTGGTGGTCACCTTCCTAGAGGGGCTCCGGAAGAGATCTAAGTATGTTGTGGCCCTGCAGGATAACCCCAACCCCGCAGGCG
AGGAGTCAGGCTTCCTCAGCTTTGCCAAGGGAGACCTCATCATCCTGGACCATGACACGGGCGAGCAGGTCATGAACTCGGGCTGGGCCA
ACGGCATCAATGAGAGGACCAAGCAGCGTGGGGACTTCCCCACCGACAGTGTGTACGTCATGCCCACTGTCACCATGCCACCGCGGGAGA
TTGTGGCCCTGGTCACCATGACTCCCGATCAGAGGCAGGACGTTGTCCGGCTCTTGCAGCTGCGAACGGCGGAGCCCGAGGTGCGTGCCA
AGCCCTACACGCTGGAGGAGTTTTCCTATGACTACTTCAGGACTGGTTCGTTGTAAACCCAACAACAACCAAAAGCTTTGAAAAGCTGAT
GAAGATAAAGCAGCGGCAGCAAGAAGAAGAAAAGCGGAGGCAGCAGCACAGGAGCAGAAGGTCTCTAAGAAGGCGGCAGCAGCCTGGCAT
TGAGCTTCCCGAGACAGAGCTGAGTCTTAGAGTAGGGAAGGATCAGAGGAGGAATAATGAGGAACTGGTAGTGTCAGCCTCCTGTAAGGA
ACCAGAGCAGGAGCCAGTGCCAGCACAGTTCCAGAAAGTAAAGCCCCCAAAGACTAATCATAAACGAGGAAGGAAATAGGCAGTCAGTGT
AAAAGTGCTCCTAGGAAAGCAGATGTGATGCTGTTGTCACGGGGACCTGTGCTGGGAGGACTGAGTGAAGATTCTTTCAGCTGTTTGTGT
AAGGCTGTGACTTTCTCAGCTCCTTCCTCCTGTGTAAATTTCACTGTCTTCCCTTCTTACATTTTGATTCCCCCCTCCCCTTTTAGTAGG
TTTTCCTGCTATTCCTCGTCAAGTCCTCTTGTTTTTTTATCTTGCCCAAAGAGCTCCCTCTCAAGGCCAACTATAGGCTCCTCTTGCCCT
GTACAAAACTAAGAAACCTCTTTGGTTGTCCTTTCCTTCCTGGGGTATAGAATGTTCTTGGAAGCTCCATTGATTTAGTAGCTGCTCCAT
CATCTAGCTTGTGAAACCATTCCAAACTAATTTTTTAAAACCATAACTGATTTGTCATTTTGTATTTGTGATATAACAAGTCTAGAAGTT
AGAACTGTTGTCATTCACATAATAAGATTACTCTGTCTCCTTGGGAAAAAAACTTTATGGAGGCTGTTTGTCCTCTCAATATGGTTTTAA
GATTGAAAGTAAGAAAACGGATTTAGGATGAAAACTCTAGAACTACCCTATGCTGTTTATACTGGGAAATGCTTTGTACCAAGTAGCAGT
GACTAGACCCACAGACATGAAAAGCAACCTTAGGAGTAAAGTGACCCAAACATTAAAATGACAGGAAAGAGAAAGTAGAAGCAGCAATAA
ATACTGCCCCAACTTTCCTGGAGCCCGAGGCCTCATCCATAGCTATGATCACTTGCCCTCTGAAGCTTATTTTTGCTTCTTTGGTTTTAA
GAATTGAGAAATATCACATTGCCCCTGATGTTTTGACAGTCTCCTAGTGCTCCTGGTAGTGCCACTAAGGGAAAACCAAGGTGCGCATTC
CTTCTCCCTGGACTTTACCTTACTTGTTAGTCTACGCCCCACTGTTTCCACCCATCCCCTTAGCCAACCTCTGTCTTTTTGAATTTTCTG
AGAATATTGTCCTATCCTCTTTTATATATGGAGTTCTCTCCTCTTTATATCCTGAGACTTTGACACCAGATGTAGATATTTATCTGGAGC
TGGAAAGAAAAATTCTTTTTCTGTACCTCATGCCTATCTGGTAATGTTTAATGGGTTATTTCTCTTTGAGGGTGGCTTTCTCTGGAACAT
TGGTTAGAGCAGCTTTGTTGTCGTGTTTCTGGATTCTCTTCCCCATTTTGCGTAAATATTGGTCTTATATATTCTTGCCTATTTTGTGGC
ATATGCCACATAAAAAATGAACCTGATATAGACAAGTACTACCTTTTCAAATTCTGAAAGGCTATTACCACTTTAACTCTTTGTGCTCCT
CCAAATAGCTTTAAAATGTGGGCTTTTGTGAAGACCACTTTCAAACAAGGGAGCACTGAAACCTGAATTGGATACTGCCAGAATAGGTAG
TTTTGAAACAAGTTAAGGACATGGTATATGCACTCTGCATTTTCATTGGCAGTGTGCCCTTAAAGCCCTTTCAGTAGATGAGGGTTGTCA
GGGAGGAGAAATGAAGAAGCTATGTTAATTTCTGGTGAGTAAGACCTGGGGAATGTTTGGCAATGACAAAAGAAATAAATGACTCTCAGA

>56760_56760_2_MYO7A-ZNF512_MYO7A_chr11_76913469_ENST00000409709_ZNF512_chr2_27844020_ENST00000379717_length(amino acids)=1727AA_BP=
MVILQQGDHVWMDLRLGQEFDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYR
DHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAISG
QHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFYCMLEGMSEDQKKKL
GLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEARTFENLDACEVLFSPSLATAASLLE
VNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFE
QLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLNANYIP
PKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQP
FFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQ
IGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQY
RLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKKAKEEAERKHQER
LAQLAREDAERELKEKEAARRKKELLEQMERARHEPVNHSDMVDKMFGFLGTSGGLPGQEGQAPSGFEDLERGRREMVEEDLDAALPLPD
EDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGK
KTYKRELQALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHDGESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDE
IYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIML
PVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEV
FTPWHSPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKTLEKWAQLAIAAHK
KGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRECRVWLS
LGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKTTAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGE
ESGFLSFAKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDSVYVMPTVTMPPREIVALVTMTPDQRQDVVRLLQLRTAEPEVRAK

--------------------------------------------------------------
>56760_56760_3_MYO7A-ZNF512_MYO7A_chr11_76913469_ENST00000458637_ZNF512_chr2_27844020_ENST00000379717_length(transcript)=7262nt_BP=5320nt
GGCAGGAGAGAGAGGGAGAGACAAGAGACACACACAGAGAGACGGCGAGGAAGGGAAAGACCCAGAGGGACGCCTAGAACGAGACTTGGA
GCCAGACAGAGGAAGAGGGGACGTGTGTTTGCAGACTGGCTGGGCCCGTGACCCAGCTTCCTGAGTCCTCCGTGCAGGTGGCAGCTGTAC
CAGGCTGGCAGGTCACTGAGAGTGGGCAGCTGGGCCCCAGAACTGTGCCTGGCCCAGTGGGCAGCAGGAGCTCCTGACTTGGGACCATGG
TGATTCTTCAGCAGGGGGACCATGTGTGGATGGACCTGAGATTGGGGCAGGAGTTCGACGTGCCCATCGGGGCGGTGGTGAAGCTCTGCG
ACTCTGGGCAGGTCCAGGTGGTGGATGATGAAGACAATGAACACTGGATCTCTCCGCAGAACGCAACGCACATCAAGCCTATGCACCCCA
CGTCGGTCCACGGCGTGGAGGACATGATCCGCCTGGGGGACCTCAACGAGGCGGGCATCTTGCGCAACCTGCTTATCCGCTACCGGGACC
ACCTCATCTACACGTATACGGGCTCCATCCTGGTGGCTGTGAACCCCTACCAGCTGCTCTCCATCTACTCGCCAGAGCACATCCGCCAGT
ATACCAACAAGAAGATTGGGGAGATGCCCCCCCACATCTTTGCCATTGCTGACAACTGCTACTTCAACATGAAACGCAACAGCCGAGACC
AGTGCTGCATCATCAGTGGGGAATCTGGGGCCGGGAAGACGGAGAGCACAAAGCTGATCCTGCAGTTCCTGGCAGCCATCAGTGGGCAGC
ACTCGTGGATTGAGCAGCAGGTCTTGGAGGCCACCCCCATTCTGGAAGCATTTGGGAATGCCAAGACCATCCGCAATGACAACTCAAGCC
GTTTCGGAAAGTACATCGACATCCACTTCAACAAGCGGGGCGCCATCGAGGGCGCGAAGATTGAGCAGTACCTGCTGGAAAAGTCACGTG
TCTGTCGCCAGGCCCTGGATGAAAGGAACTACCACGTGTTCTACTGCATGCTGGAGGGTATGAGTGAGGATCAGAAGAAGAAGCTGGGCT
TGGGCCAGGCCTCTGACTACAACTACTTGGCCATGGGTAACTGCATAACCTGTGAGGGCCGGGTGGACAGCCAGGAGTACGCCAACATCC
GCTCCGCCATGAAGGTGCTCATGTTCACTGACACCGAGAACTGGGAGATCTCGAAGCTCCTGGCTGCCATCCTGCACCTGGGCAACCTGC
AGTATGAGGCACGCACATTTGAAAACCTGGATGCCTGTGAGGTTCTCTTCTCCCCATCGCTGGCCACAGCTGCATCCCTGCTTGAGGTGA
ACCCCCCAGACCTGATGAGCTGCCTGACTAGCCGCACCCTCATCACCCGCGGGGAGACGGTGTCCACCCCACTGAGCAGGGAACAGGCAC
TGGACGTGCGCGACGCCTTCGTAAAGGGGATCTACGGGCGGCTGTTCGTGTGGATTGTGGACAAGATCAACGCAGCAATTTACAAGCCTC
CCTCCCAGGATGTGAAGAACTCTCGCAGGTCCATCGGCCTCCTGGACATCTTTGGGTTTGAGAACTTTGCTGTGAACAGCTTTGAGCAGC
TCTGCATCAACTTCGCCAATGAGCACCTGCAGCAGTTCTTTGTGCGGCACGTGTTCAAGCTGGAGCAGGAGGAATATGACCTGGAGAGCA
TTGACTGGCTGCACATCGAGTTCACTGACAACCAGGATGCCCTGGACATGATTGCCAACAAGCCCATGAACATCATCTCCCTCATCGATG
AGGAGAGCAAGTTCCCCAAGGGCACAGACACCACCATGTTACACAAGCTGAACTCCCAGCACAAGCTCAACGCCAACTACATCCCCCCCA
AGAACAACCATGAGACCCAGTTTGGCATCAACCATTTTGCAGGCATCGTCTACTATGAGACCCAAGGCTTCCTGGAGAAGAACCGAGACA
CCCTGCATGGGGACATTATCCAGCTGGTCCACTCCTCCAGGAACAAGTTCATCAAGCAGATCTTCCAGGCCGATGTCGCCATGGGCGCCG
AGACCAGGAAGCGCTCGCCCACACTTAGCAGCCAGTTCAAGCGGTCACTGGAGCTGCTGATGCGCACGCTGGGTGCCTGCCAGCCCTTCT
TTGTGCGATGCATCAAGCCCAATGAGTTCAAGAAGCCCATGCTGTTCGACCGGCACCTGTGCGTGCGCCAGCTGCGGTACTCAGGAATGA
TGGAGACCATCCGAATCCGCCGAGCTGGCTACCCCATCCGCTACAGCTTCGTAGAGTTTGTGGAGCGGTACCGTGTGCTGCTGCCAGGTG
TGAAGCCGGCCTACAAGCAGGGCGACCTCCGCGGGACTTGCCAGCGCATGGCTGAGGCTGTGCTGGGCACCCACGATGACTGGCAGATAG
GCAAAACCAAGATCTTTCTGAAGGACCACCATGACATGCTGCTGGAAGTGGAGCGGGACAAAGCCATCACCGACAGAGTCATCCTCCTTC
AGAAAGTCATCCGGGGATTCAAAGACAGGTCTAACTTTCTGAAGCTGAAGAACGCTGCCACACTGATCCAGAGGCACTGGCGGGGTCACA
ACTGTAGGAAGAACTACGGGCTGATGCGTCTGGGCTTCCTGCGGCTGCAGGCCCTGCACCGCTCCCGGAAGCTGCACCAGCAGTACCGCC
TGGCCCGCCAGCGCATCATCCAGTTCCAGGCCCGCTGCCGCGCCTATCTGGTGCGCAAGGCCTTCCGCCACCGCCTCTGGGCTGTGCTCA
CCGTGCAGGCCTATGCCCGGGGCATGATCGCCCGCAGGCTGCACCAACGCCTCAGGGCTGAGTATCTGTGGCGCCTCGAGGCTGAGAAAA
TGCGGCTGGCGGAGGAAGAGAAGCTTCGGAAGGAGATGAGCGCCAAGAAGGCCAAGGAGGAGGCCGAGCGCAAGCATCAGGAGCGCCTGG
CCCAGCTGGCTCGTGAGGACGCTGAGCGGGAGCTGAAGGAGAAGGAGGCCGCTCGGCGGAAGAAGGAGCTCCTGGAGCAGATGGAAAGGG
CCCGCCATGAGCCTGTCAATCACTCAGACATGGTGGACAAGATGTTTGGCTTCCTGGGGACTTCAGGTGGCCTGCCAGGCCAGGAGGGCC
AGGCACCTAGTGGCTTTGAGGACCTGGAGCGAGGGCGGAGGGAGATGGTGGAGGAGGACCTGGATGCAGCCCTGCCCCTGCCTGACGAGG
ATGAGGAGGACCTCTCTGAGTATAAATTTGCCAAGTTCGCGGCCACCTACTTCCAGGGGACAACCACGCACTCCTACACCCGGCGGCCAC
TCAAACAGCCACTGCTCTACCATGACGACGAGGGTGACCAGCTGGCAGCCCTGGCGGTCTGGATCACCATCCTCCGCTTCATGGGGGACC
TCCCTGAGCCCAAGTACCACACAGCCATGAGTGATGGCAGTGAGAAGATCCCTGTGATGACCAAGATTTATGAGACCCTGGGCAAGAAGA
CGTACAAGAGGGAGCTGCAGGCCCTGCAGGGCGAGGGCGAGGCCCAGCTCCCCGAGGGCCAGAAGAAGAGCAGTGTGAGGCACAAGCTGG
TGCATTTGACTCTGAAAAAGAAGTCCAAGCTCACAGAGGAGGTGACCAAGAGGCTGCATGACGGGGAGTCCACAGTGCAGGGCAACAGCA
TGCTGGAGGACCGGCCCACCTCCAACCTGGAGAAGCTGCACTTCATCATCGGCAATGGCATCCTGCGGCCAGCACTCCGGGACGAGATCT
ACTGCCAGATCAGCAAGCAGCTGACCCACAACCCCTCCAAGAGCAGCTATGCCCGGGGCTGGATTCTCGTGTCTCTCTGCGTGGGCTGTT
TCGCCCCCTCCGAGAAGTTTGTCAAGTACCTGCGGAACTTCATCCACGGGGGCCCGCCCGGCTACGCCCCGTACTGTGAGGAGCGCCTGA
GAAGGACCTTTGTCAATGGGACACGGACACAGCCGCCCAGCTGGCTGGAGCTGCAGGCCACCAAGTCCAAGAAGCCAATCATGTTGCCCG
TGACATTCATGGATGGGACCACCAAGACCCTGCTGACGGACTCGGCAACCACGGCCAAGGAGCTCTGCAACGCGCTGGCCGACAAGATCT
CTCTCAAGGACCGGTTCGGGTTCTCCCTCTACATTGCCCTGTTTGACAAGGTGTCCTCCCTGGGCAGCGGCAGTGACCACGTCATGGACG
CCATCTCCCAGTGCGAGCAGTACGCCAAGGAGCAGGGCGCCCAGGAGCGCAACGCCCCCTGGAGGCTCTTCTTCCGCAAAGAGGTCTTCA
CGCCCTGGCACAGCCCCTCCGAGGACAACGTGGCCACCAACCTCATCTACCAGCAGGTGGTGCGAGGAGTCAAGTTTGGGGAGTACAGGT
GTGAGAAGGAGGACGACCTGGCTGAGCTGGCCTCCCAGCAGTACTTTGTAGACTATGGCTCTGAGATGATCCTGGAGCGCCTCCTGAACC
TCGTGCCCACCTACATCCCCGACCGCGAGATCACGCCCCTGAAGACGCTGGAGAAGTGGGCCCAGCTGGCCATCGCCGCCCACAAGAAGG
GGATTTATGCCCAGAGGAGAACTGATGCCCAGAAGGTCAAAGAGGATGTGGTCAGTTATGCCCGCTTCAAGTGGCCCTTGCTCTTCTCCA
GGTTTTATGAAGCCTACAAATTCTCAGGCCCCAGTCTCCCCAAGAACGACGTCATCGTGGCCGTCAACTGGACGGGTGTGTACTTTGTGG
ATGAGCAGGAGCAGGTACTTCTGGAGCTGTCCTTCCCAGAGATCATGGCCGTGTCCAGCAGCAGGGGAGCGAAAACGACGGCCCCCAGCT
TCACGCTGGCCACCATCAAGGGGGACGAATACACCTTCACCTCCAGCAATGCTGAGGACATTCGTGACCTGGTGGTCACCTTCCTAGAGG
GGCTCCGGAAGAGATCTAAGTATGTTGTGGCCCTGCAGGATAACCCCAACCCCGCAGGCGAGGAGTCAGGCTTCCTCAGCTTTGCCAAGG
GAGACCTCATCATCCTGGACCATGACACGGGCGAGCAGGTCATGAACTCGGGCTGGGCCAACGGCATCAATGAGAGGACCAAGCAGCGTG
GGGACTTCCCCACCGACAGTGTGTACGTCATGCCCACTGTCACCATGCCACCGCGGGAGATTGTGGCCCTGGTCACCATGACTCCCGATC
AGAGGCAGGACGTTGTCCGGCTCTTGCAGCTGCGAACGGCGGAGCCCGAGGTGCGTGCCAAGCCCTACACGCTGGAGGAGTTTTCCTATG
ACTACTTCAGGACTGGTTCGTTGTAAACCCAACAACAACCAAAAGCTTTGAAAAGCTGATGAAGATAAAGCAGCGGCAGCAAGAAGAAGA
AAAGCGGAGGCAGCAGCACAGGAGCAGAAGGTCTCTAAGAAGGCGGCAGCAGCCTGGCATTGAGCTTCCCGAGACAGAGCTGAGTCTTAG
AGTAGGGAAGGATCAGAGGAGGAATAATGAGGAACTGGTAGTGTCAGCCTCCTGTAAGGAACCAGAGCAGGAGCCAGTGCCAGCACAGTT
CCAGAAAGTAAAGCCCCCAAAGACTAATCATAAACGAGGAAGGAAATAGGCAGTCAGTGTAAAAGTGCTCCTAGGAAAGCAGATGTGATG
CTGTTGTCACGGGGACCTGTGCTGGGAGGACTGAGTGAAGATTCTTTCAGCTGTTTGTGTAAGGCTGTGACTTTCTCAGCTCCTTCCTCC
TGTGTAAATTTCACTGTCTTCCCTTCTTACATTTTGATTCCCCCCTCCCCTTTTAGTAGGTTTTCCTGCTATTCCTCGTCAAGTCCTCTT
GTTTTTTTATCTTGCCCAAAGAGCTCCCTCTCAAGGCCAACTATAGGCTCCTCTTGCCCTGTACAAAACTAAGAAACCTCTTTGGTTGTC
CTTTCCTTCCTGGGGTATAGAATGTTCTTGGAAGCTCCATTGATTTAGTAGCTGCTCCATCATCTAGCTTGTGAAACCATTCCAAACTAA
TTTTTTAAAACCATAACTGATTTGTCATTTTGTATTTGTGATATAACAAGTCTAGAAGTTAGAACTGTTGTCATTCACATAATAAGATTA
CTCTGTCTCCTTGGGAAAAAAACTTTATGGAGGCTGTTTGTCCTCTCAATATGGTTTTAAGATTGAAAGTAAGAAAACGGATTTAGGATG
AAAACTCTAGAACTACCCTATGCTGTTTATACTGGGAAATGCTTTGTACCAAGTAGCAGTGACTAGACCCACAGACATGAAAAGCAACCT
TAGGAGTAAAGTGACCCAAACATTAAAATGACAGGAAAGAGAAAGTAGAAGCAGCAATAAATACTGCCCCAACTTTCCTGGAGCCCGAGG
CCTCATCCATAGCTATGATCACTTGCCCTCTGAAGCTTATTTTTGCTTCTTTGGTTTTAAGAATTGAGAAATATCACATTGCCCCTGATG
TTTTGACAGTCTCCTAGTGCTCCTGGTAGTGCCACTAAGGGAAAACCAAGGTGCGCATTCCTTCTCCCTGGACTTTACCTTACTTGTTAG
TCTACGCCCCACTGTTTCCACCCATCCCCTTAGCCAACCTCTGTCTTTTTGAATTTTCTGAGAATATTGTCCTATCCTCTTTTATATATG
GAGTTCTCTCCTCTTTATATCCTGAGACTTTGACACCAGATGTAGATATTTATCTGGAGCTGGAAAGAAAAATTCTTTTTCTGTACCTCA
TGCCTATCTGGTAATGTTTAATGGGTTATTTCTCTTTGAGGGTGGCTTTCTCTGGAACATTGGTTAGAGCAGCTTTGTTGTCGTGTTTCT
GGATTCTCTTCCCCATTTTGCGTAAATATTGGTCTTATATATTCTTGCCTATTTTGTGGCATATGCCACATAAAAAATGAACCTGATATA
GACAAGTACTACCTTTTCAAATTCTGAAAGGCTATTACCACTTTAACTCTTTGTGCTCCTCCAAATAGCTTTAAAATGTGGGCTTTTGTG
AAGACCACTTTCAAACAAGGGAGCACTGAAACCTGAATTGGATACTGCCAGAATAGGTAGTTTTGAAACAAGTTAAGGACATGGTATATG
CACTCTGCATTTTCATTGGCAGTGTGCCCTTAAAGCCCTTTCAGTAGATGAGGGTTGTCAGGGAGGAGAAATGAAGAAGCTATGTTAATT

>56760_56760_3_MYO7A-ZNF512_MYO7A_chr11_76913469_ENST00000458637_ZNF512_chr2_27844020_ENST00000379717_length(amino acids)=1689AA_BP=
MVILQQGDHVWMDLRLGQEFDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYR
DHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAISG
QHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFYCMLEGMSEDQKKKL
GLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEARTFENLDACEVLFSPSLATAASLLE
VNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFE
QLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLNANYIP
PKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQP
FFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQ
IGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQY
RLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKKAKEEAERKHQER
LAQLAREDAERELKEKEAARRKKELLEQMERARHEPVNHSDMVDKMFGFLGTSGGLPGQEGQAPSGFEDLERGRREMVEEDLDAALPLPD
EDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGK
KTYKRELQALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHDGESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDE
IYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIML
PVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEV
FTPWHSPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKTLEKWAQLAIAAHK
KGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRGAKTTAP
SFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMNSGWANGINERTKQ

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Top

Fusion Gene PPI Analysis for MYO7A-ZNF512

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MYO7A-ZNF512

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MYO7A-ZNF512

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source