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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO9B-DDA1 (FusionGDB2 ID:56789)

Fusion Gene Summary for MYO9B-DDA1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO9B-DDA1
Fusion gene ID: 56789
HgeneTgene
Gene symbol

MYO9B

DDA1

Gene ID

4650

79016

Gene namemyosin IXBDET1 and DDB1 associated 1
SynonymsCELIAC4|MYR5C19orf58|PCIA1
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IXbmyosin-IXbunconventional myosin-9bDET1- and DDB1-associated protein 1cross-immune reaction antigen PCIA1placenta cross-immune reaction antigen 1
Modification date2020031320200327
UniProtAcc

Q13459

Q9BW61

Ensembl transtripts involved in fusion geneENST00000593411, ENST00000397274, 
ENST00000594824, ENST00000595618, 
ENST00000359866, 
Fusion gene scores* DoF score22 X 11 X 11=26623 X 4 X 2=24
# samples 244
** MAII scorelog2(24/2662*10)=-3.47140426030337
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYO9B [Title/Abstract] AND DDA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDA1(17420466)-MYO9B(17311448), # samples:3
MYO9B(17213367)-DDA1(17424832), # samples:2
Anticipated loss of major functional domain due to fusion event.DDA1-MYO9B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DDA1-MYO9B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO9B

GO:0030048

actin filament-based movement

9490638

HgeneMYO9B

GO:0032011

ARF protein signal transduction

15644318

HgeneMYO9B

GO:0035385

Roundabout signaling pathway

26529257


check buttonFusion gene breakpoints across MYO9B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FJ-01AMYO9Bchr19

17213367

+DDA1chr19

17424832

+
ChimerDB4BRCATCGA-AN-A0FJMYO9Bchr19

17213367

+DDA1chr19

17424831

+


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Fusion Gene ORF analysis for MYO9B-DDA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000593411ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424832

+
3UTR-3CDSENST00000593411ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424831

+
In-frameENST00000397274ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424832

+
In-frameENST00000397274ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424831

+
In-frameENST00000594824ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424832

+
In-frameENST00000594824ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424831

+
In-frameENST00000595618ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424832

+
In-frameENST00000595618ENST00000359866MYO9Bchr19

17213367

+DDA1chr19

17424831

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000595618MYO9Bchr1917213367+ENST00000359866DDA1chr1917424832+49439921521297381
ENST00000594824MYO9Bchr1917213367+ENST00000359866DDA1chr1917424832+49389871471292381
ENST00000397274MYO9Bchr1917213367+ENST00000359866DDA1chr1917424832+4853902621207381
ENST00000595618MYO9Bchr1917213367+ENST00000359866DDA1chr1917424831+49439921521297381
ENST00000594824MYO9Bchr1917213367+ENST00000359866DDA1chr1917424831+49389871471292381
ENST00000397274MYO9Bchr1917213367+ENST00000359866DDA1chr1917424831+4853902621207381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000595618ENST00000359866MYO9Bchr1917213367+DDA1chr1917424832+0.0039224810.9960775
ENST00000594824ENST00000359866MYO9Bchr1917213367+DDA1chr1917424832+0.0039511030.99604887
ENST00000397274ENST00000359866MYO9Bchr1917213367+DDA1chr1917424832+0.0038986810.99610126
ENST00000595618ENST00000359866MYO9Bchr1917213367+DDA1chr1917424831+0.0039224810.9960775
ENST00000594824ENST00000359866MYO9Bchr1917213367+DDA1chr1917424831+0.0039511030.99604887
ENST00000397274ENST00000359866MYO9Bchr1917213367+DDA1chr1917424831+0.0038986810.99610126

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Fusion Genomic Features for MYO9B-DDA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MYO9B-DDA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:17420466/chr19:17311448)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO9B

Q13459

DDA1

Q9BW61

FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.FUNCTION: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272). {ECO:0000269|PubMed:17452440, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31819272}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+13915_1142802189.0DomainRas-associating
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+24015_1142802458.6666666666665DomainRas-associating
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+13915_1142802189.0DomainRas-associating
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+24015_1142802458.6666666666665DomainRas-associating
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+139239_2462802189.0Nucleotide bindingATP
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+240239_2462802458.6666666666665Nucleotide bindingATP
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+139239_2462802189.0Nucleotide bindingATP
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+240239_2462802458.6666666666665Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391046_10712802189.0Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391880_19012802189.0Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391959_19892802189.0Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401046_10712802458.6666666666665Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401880_19012802458.6666666666665Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401959_19892802458.6666666666665Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391046_10712802189.0Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391880_19012802189.0Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391959_19892802189.0Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401046_10712802458.6666666666665Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401880_19012802458.6666666666665Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401959_19892802458.6666666666665Coiled coilOntology_term=ECO:0000255
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391001_10232802189.0DomainIQ 3
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391024_10532802189.0DomainIQ 4
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+139146_9532802189.0DomainMyosin motor
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391703_18882802189.0DomainRho-GAP
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+139957_9772802189.0DomainIQ 1
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+139979_10002802189.0DomainIQ 2
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401001_10232802458.6666666666665DomainIQ 3
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401024_10532802458.6666666666665DomainIQ 4
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+240146_9532802458.6666666666665DomainMyosin motor
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401703_18882802458.6666666666665DomainRho-GAP
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+240957_9772802458.6666666666665DomainIQ 1
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+240979_10002802458.6666666666665DomainIQ 2
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391001_10232802189.0DomainIQ 3
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391024_10532802189.0DomainIQ 4
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+139146_9532802189.0DomainMyosin motor
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391703_18882802189.0DomainRho-GAP
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+139957_9772802189.0DomainIQ 1
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+139979_10002802189.0DomainIQ 2
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401001_10232802458.6666666666665DomainIQ 3
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401024_10532802458.6666666666665DomainIQ 4
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+240146_9532802458.6666666666665DomainMyosin motor
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401703_18882802458.6666666666665DomainRho-GAP
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+240957_9772802458.6666666666665DomainIQ 1
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+240979_10002802458.6666666666665DomainIQ 2
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391045_21572802189.0RegionTail
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+139844_8552802189.0RegionActin-binding
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+139940_10442802189.0RegionNeck or regulatory domain
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401045_21572802458.6666666666665RegionTail
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+240844_8552802458.6666666666665RegionActin-binding
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+240940_10442802458.6666666666665RegionNeck or regulatory domain
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391045_21572802189.0RegionTail
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+139844_8552802189.0RegionActin-binding
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+139940_10442802189.0RegionNeck or regulatory domain
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401045_21572802458.6666666666665RegionTail
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+240844_8552802458.6666666666665RegionActin-binding
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+240940_10442802458.6666666666665RegionNeck or regulatory domain
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391632_16812802189.0Zinc fingerPhorbol-ester/DAG-type
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401632_16812802458.6666666666665Zinc fingerPhorbol-ester/DAG-type
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391632_16812802189.0Zinc fingerPhorbol-ester/DAG-type
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401632_16812802458.6666666666665Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for MYO9B-DDA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56789_56789_1_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000397274_DDA1_chr19_17424831_ENST00000359866_length(transcript)=4853nt_BP=902nt
CTAGCTCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGG
GCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCA
AGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAG
AGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACC
CTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCA
CAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGG
GCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTA
AGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCG
ACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCA
ACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGG
AGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGAC
GGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATC
AGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGG
CGCGGACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCAC
CCGCCTGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAG
GAGCCGATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTG
ATGTTGGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTC
TCCAGAGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTA
CCAGGACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCA
TGCCCAGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACT
AGTGCGTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAG
CCCCTGGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGC
TTGCTGAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCC
TGAGAGACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCG
CAGAGATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCG
GTCTTGCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATG
GCCGCTCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGT
TTGTGGCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCT
TTTGTTTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCC
TCGACCTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTT
TGAGATGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATT
CTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTT
GTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCC
TGGCTAATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCT
TCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTG
GGATGGTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCC
TGTGTCAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGAC
CAGGCCCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGG
TCACAGGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTG
GGGAGTCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAA
GGCCAGGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTG
GCTGGGGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCC
CTCCTTTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGG
CACACACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCC
CTTTACCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCA
CAGCCTCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACA
CATTTGTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTG
ATGTCTGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCAC
AAGTCGGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGAT
GTTCCAGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGC
CTGTGCACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATC
TGGGCCGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGC
CTGTACCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCT

>56789_56789_1_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000397274_DDA1_chr19_17424831_ENST00000359866_length(amino acids)=381AA_BP=0
MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL
WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG
SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER
TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG

--------------------------------------------------------------
>56789_56789_2_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000397274_DDA1_chr19_17424832_ENST00000359866_length(transcript)=4853nt_BP=902nt
CTAGCTCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGG
GCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCA
AGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAG
AGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACC
CTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCA
CAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGG
GCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTA
AGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCG
ACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCA
ACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGG
AGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGAC
GGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATC
AGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGG
CGCGGACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCAC
CCGCCTGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAG
GAGCCGATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTG
ATGTTGGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTC
TCCAGAGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTA
CCAGGACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCA
TGCCCAGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACT
AGTGCGTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAG
CCCCTGGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGC
TTGCTGAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCC
TGAGAGACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCG
CAGAGATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCG
GTCTTGCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATG
GCCGCTCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGT
TTGTGGCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCT
TTTGTTTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCC
TCGACCTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTT
TGAGATGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATT
CTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTT
GTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCC
TGGCTAATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCT
TCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTG
GGATGGTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCC
TGTGTCAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGAC
CAGGCCCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGG
TCACAGGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTG
GGGAGTCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAA
GGCCAGGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTG
GCTGGGGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCC
CTCCTTTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGG
CACACACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCC
CTTTACCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCA
CAGCCTCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACA
CATTTGTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTG
ATGTCTGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCAC
AAGTCGGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGAT
GTTCCAGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGC
CTGTGCACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATC
TGGGCCGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGC
CTGTACCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCT

>56789_56789_2_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000397274_DDA1_chr19_17424832_ENST00000359866_length(amino acids)=381AA_BP=0
MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL
WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG
SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER
TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG

--------------------------------------------------------------
>56789_56789_3_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000594824_DDA1_chr19_17424831_ENST00000359866_length(transcript)=4938nt_BP=987nt
CGGAGCGGCTCGAGCAGCGGCGGGCTGGCAGGCGGTCGTCCGGCCGGGGACCCGGCCCGGGACCGGCGGCGCGCGGCGGCCGAGGCCAGC
TCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGGGCCGC
CGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCAAGGAC
AGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAGAGTCG
GGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACCCTCAG
GAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCACAGCC
ACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGGGCAAC
CTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTAAGTTC
CTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCGACGTG
GCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCAACTTC
CTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGGAGGCA
GATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGACGGCCC
TCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATCAGCAA
TGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGGCGCGG
ACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCACCCGCC
TGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAGGAGCC
GATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTGATGTT
GGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTCTCCAG
AGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTACCAGG
ACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCATGCCC
AGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACTAGTGC
GTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAGCCCCT
GGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGCTTGCT
GAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCCTGAGA
GACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCGCAGAG
ATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCGGTCTT
GCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATGGCCGC
TCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGTTTGTG
GCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCTTTTGT
TTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCCTCGAC
CTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTTTGAGA
TGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCT
ACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTTGTCAT
GTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCCTGGCT
AATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCTTCCTC
AGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTGGGATG
GTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCCTGTGT
CAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGACCAGGC
CCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGGTCACA
GGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTGGGGAG
TCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAAGGCCA
GGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTGGCTGG
GGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCCCTCCT
TTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGGCACAC
ACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCCCTTTA
CCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCACAGCC
TCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACACATTT
GTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTGATGTC
TGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCACAAGTC
GGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGATGTTCC
AGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGCCTGTG
CACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATCTGGGC
CGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGCCTGTA
CCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCTCGGGC

>56789_56789_3_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000594824_DDA1_chr19_17424831_ENST00000359866_length(amino acids)=381AA_BP=0
MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL
WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG
SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER
TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG

--------------------------------------------------------------
>56789_56789_4_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000594824_DDA1_chr19_17424832_ENST00000359866_length(transcript)=4938nt_BP=987nt
CGGAGCGGCTCGAGCAGCGGCGGGCTGGCAGGCGGTCGTCCGGCCGGGGACCCGGCCCGGGACCGGCGGCGCGCGGCGGCCGAGGCCAGC
TCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGGGCCGC
CGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCAAGGAC
AGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAGAGTCG
GGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACCCTCAG
GAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCACAGCC
ACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGGGCAAC
CTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTAAGTTC
CTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCGACGTG
GCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCAACTTC
CTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGGAGGCA
GATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGACGGCCC
TCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATCAGCAA
TGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGGCGCGG
ACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCACCCGCC
TGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAGGAGCC
GATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTGATGTT
GGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTCTCCAG
AGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTACCAGG
ACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCATGCCC
AGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACTAGTGC
GTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAGCCCCT
GGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGCTTGCT
GAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCCTGAGA
GACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCGCAGAG
ATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCGGTCTT
GCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATGGCCGC
TCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGTTTGTG
GCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCTTTTGT
TTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCCTCGAC
CTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTTTGAGA
TGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCT
ACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTTGTCAT
GTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCCTGGCT
AATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCTTCCTC
AGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTGGGATG
GTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCCTGTGT
CAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGACCAGGC
CCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGGTCACA
GGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTGGGGAG
TCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAAGGCCA
GGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTGGCTGG
GGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCCCTCCT
TTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGGCACAC
ACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCCCTTTA
CCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCACAGCC
TCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACACATTT
GTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTGATGTC
TGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCACAAGTC
GGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGATGTTCC
AGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGCCTGTG
CACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATCTGGGC
CGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGCCTGTA
CCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCTCGGGC

>56789_56789_4_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000594824_DDA1_chr19_17424832_ENST00000359866_length(amino acids)=381AA_BP=0
MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL
WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG
SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER
TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG

--------------------------------------------------------------
>56789_56789_5_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000595618_DDA1_chr19_17424831_ENST00000359866_length(transcript)=4943nt_BP=992nt
CGGGGCGGAGCGGCTCGAGCAGCGGCGGGCTGGCAGGCGGTCGTCCGGCCGGGGACCCGGCCCGGGACCGGCGGCGCGCGGCGGCCGAGG
CCAGCTCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGG
GCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCA
AGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAG
AGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACC
CTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCA
CAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGG
GCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTA
AGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCG
ACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCA
ACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGG
AGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGAC
GGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATC
AGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGG
CGCGGACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCAC
CCGCCTGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAG
GAGCCGATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTG
ATGTTGGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTC
TCCAGAGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTA
CCAGGACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCA
TGCCCAGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACT
AGTGCGTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAG
CCCCTGGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGC
TTGCTGAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCC
TGAGAGACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCG
CAGAGATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCG
GTCTTGCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATG
GCCGCTCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGT
TTGTGGCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCT
TTTGTTTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCC
TCGACCTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTT
TGAGATGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATT
CTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTT
GTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCC
TGGCTAATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCT
TCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTG
GGATGGTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCC
TGTGTCAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGAC
CAGGCCCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGG
TCACAGGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTG
GGGAGTCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAA
GGCCAGGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTG
GCTGGGGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCC
CTCCTTTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGG
CACACACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCC
CTTTACCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCA
CAGCCTCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACA
CATTTGTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTG
ATGTCTGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCAC
AAGTCGGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGAT
GTTCCAGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGC
CTGTGCACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATC
TGGGCCGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGC
CTGTACCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCT

>56789_56789_5_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000595618_DDA1_chr19_17424831_ENST00000359866_length(amino acids)=381AA_BP=0
MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL
WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG
SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER
TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG

--------------------------------------------------------------
>56789_56789_6_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000595618_DDA1_chr19_17424832_ENST00000359866_length(transcript)=4943nt_BP=992nt
CGGGGCGGAGCGGCTCGAGCAGCGGCGGGCTGGCAGGCGGTCGTCCGGCCGGGGACCCGGCCCGGGACCGGCGGCGCGCGGCGGCCGAGG
CCAGCTCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGG
GCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCA
AGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAG
AGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACC
CTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCA
CAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGG
GCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTA
AGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCG
ACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCA
ACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGG
AGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGAC
GGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGATCATCGTGACAGAAAAGACAAACATCCTCCTGCGCTACCTGCATC
AGCAATGGGACAAAAAGAACGCTGCCAAGAAGAGAGACCAGGAGCAAGTGGAGCTGGAAGGCGAGAGCTCCGCACCTCCCCGCAAGGTGG
CGCGGACCGACAGCCCAGACATGCACGAGGACACTTAAGACTCTCAACTCCACAGGCGCCTCCTGCCAGGTCTGCTCCTCGGTCGCCCAC
CCGCCTGCCCGCCATGTGTAAGCACCCCGCCCGCCCGCCTCCCTGCCGGCCCATCCACACCCTGCGTCCACACCACTTCCAACCTCATAG
GAGCCGATGTATTTATTTTCCTTGAGTTTTTATTTATGCTGTAACCTGTATCAAGCGTTGGTTAAAGGGGACATCAGACCCAGTAGTGTG
ATGTTGGTAGATGCTTTTTAAAAAAAACAACATTGTCCCCCCGACCCCCGCCTTCCATCGGGCCAGTTCCCCGATTCCTGCCCCCAGTTC
TCCAGAGAACCAGAGTGTGTCTGTGAGAGTCTCTAGCGGGGGCTTTACTGTGGCCGGGCGACAGGGGCGGGCCCGGGGTGGCCTGACCTA
CCAGGACAGCCGAGTGGCCTTCTCCCCCCCAACACCGGTCCAGGCCATTGAGACTCGGTCTTGTCCCACGCTTCGCCCGGAACTTTCCCA
TGCCCAGGCCTCACTCAGCGTGCACGCACGTTGGGGAGAAGTCGGCCCTTGGGATCTTTCTCTTGAGTCATTTTATTTTTATCATGGACT
AGTGCGTGCTCCGTGTCCACCCCAATAAAAGGGTCTTTCCTACTTGACCTCGCGTCTTTGCTCCACACACCTTGGCTGCAGAGGACGGAG
CCCCTGGGAGTCATCCCTGTTGTCACCAAGAGGAGTGAGAAGGGCCCCCCACGCCAGGGGCCCCAGGACCGGCTGGATTCTCTCGTGGGC
TTGCTGAGGCCACCATGTTCAAGGCCAAGACCTGCCTGGACCATCCCCTCTGCCTCTCCTGTCAAGGTGACCCCAAGGACAGGTCATTCC
TGAGAGACGGTCCATGGTGCCAAGGATGGAGCGGGGTCAGCCCCCTGCCTGGGATACCGCCAAGCAGGGCAGCGCACCTGTCAGACACCG
CAGAGATGGCCGGCCTCATCCGGGGGCCTGGGGTCTCTGGCCTCTGCTGCTCCCCTGAGGCATGGTGACAGTACAGACGGCATCTGGCCG
GTCTTGCTGTCCTAGGTGGTGGCCTCACCCTTGCTGGGTCATAGAGGAGCTGTACAGAAGGTTGGCACCTGGCAGTTGGCATGTGCCATG
GCCGCTCATGGGGACCCCTCTTCCGCCAGCTGGGCTGGGTTTGGGGCTGAGCTTGGGTATGTAGGGGTGTTCGGGCTCTGGGCAGAAGGT
TTGTGGCCCTGACCACTGAGCCTGGGGCTGGGGGAACACCGCTTCTCCCCTTATTGCCCCCACTGGTGGTGGTGGGGATCTCAGTTTTCT
TTTGTTTTGTTTTGTTTGTTTGTTTGAGTTGGGGTCTTGTACTCTTTCCCAGGCTGGAGTGCAGTGGCGTAATCACAGCTCACTGCAGCC
TCGACCTCAAGCCTTCCTCCCACCTCAGCCTTCCAAGCCGCTGGGACCACAGGCACCCACCACCATGCCTGGCTAATTTTTTTTTTTTTT
TGAGATGGAGTCTCGCTGTGTCTCCCAGGCTGGAGTGCAGTGGCAAGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATT
CTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACACGCGTGCGCCCCTACACCCAGCTAATTTTTCTATTTTTAGTGGAGACGGCGTTTT
GTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGCTTCGCCTGCCTCGGCCTCCCAAAGTGCTGTGACCGCACCTGGCTGCC
TGGCTAATATTTTAAAAATTTTTTGTAGAGACAGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTCATCCACCT
TCCTCAGCCTCCCAAAGTGCTGGGGTTACAGACGTGAACCACCGTGCCTGGCAGAGGTCTCTGTTTTGAGAGCTGAGTCTGAGGGCGTTG
GGATGGTGTAGGGTTGGGCCACAGAGCTAGCAGACACTCCGGGCTATGGAGGGTCCGCCTGCCCCAGATTCCACTGTGGAGGGCCCTGCC
TGTGTCAGACCCTCGGGCCTAGGCGGCCCATCTCTCCCAAGGACGGAGAGTGCCAGGGTGGGCTCCCGTCCTACACAAGGAGTGGCTGAC
CAGGCCCAGGCACAGCACAGCCACCCTGCTGTACCTCCCAGCTCCCGGCAGTGTCTACACCACAGTGATGGTGCTACAGGGGCCATGTGG
TCACAGGACAGGTGGTCAGGAAATGCACACTTGACTGCGGTCGATGGTGCCGGGTCCGGCTGAATGCCCTGGAGGCTCCCAGGCCAGCTG
GGGAGTCCCAGTCCCCAGGGTTGGTGTGACCTGGGCAGGCCTGCGGTGTCCATCTGTGAATGACTGAGATGGTGGGACTTCAGCTTCCAA
GGCCAGGGGCCAGAGTGGGAGCAGGGGGCACTCCCGCCTTTCCCCTCGGCCTGTCTAGACCTCTCTGGCTCCCAGTTTCTGCTTTGAGTG
GCTGGGGGCTGTCTCCTGCCTGTGCTGTCTGCCCGTCGCTCTGCAGGGCTGCTGGGCGGGCACCTCCTTCCCCTCCCCTACCTCAGCTCC
CTCCTTTGGGGTCTGAGGGCTGTGCCCCAGCTTGCCTCCCTGTGGCCTCCCCCTAGAACCCCTGGGTCTGTCGGGACATGCCCCACCTGG
CACACACACCCTGTGTAGCTCCCACTGCCTGTGGGAGGACGCTGGGCCCCTGAGCCGGCCTCTGTCTACCCCTCCTGCCTTTGGGGTCCC
CTTTACCCCACTGTTCCCCCAAACTGCCTTCCACCTTCTCCGCCTTTGCACAGGCTGTTCTCCTGCCTCCAGTGAACTCTGACTTCTCCA
CAGCCTCCCAAAGGGCCCCTTGCTCACACTGGCCCAGCCCTGCAGCATGGCCATGTTGGTCTCTGAGCCTTAAGCCTTTGGATGTGGACA
CATTTGTCCTCTTCCTGAAAAATGTGAGGGTCTGAGAGGCCACGTTCCTGTTCCTGAGTCATACGACAGAGTCCCAGTGACTTGGGTCTG
ATGTCTGTCCCACAGTGGGACATCCCTGCTGCATCCCAATGCCACCCCGTGTCCTGGGGACACCCAAATGTGCCATTCTCTCAGTATCAC
AAGTCGGGGACTGCAGGAGGCTCAGGTGCCAGGTGCCTTCTGATGTTCATGCCACAAGCTCTTCCCACTGTCTCTGGCTCCCCAGACGAT
GTTCCAGGAGGCGGGTGTGCCAGAAGGGGCCACGTCTTGCAAACCACCGCGCTGTCCTCTTTGAGAAGGAGTCTTACTCAGGACTGGGGC
CTGTGCACACATTGTCGCCTCTTTTCAGCACTTAGAGATTCCTTCCTTTGTCTAGTGGCTGAAGCCAGGGCTGAAGTTGGCCTCCAAATC
TGGGCCGTCTCAGAGGCGGCGCAGCCTGGAGTTTTCCATCTGTGGCCAAGACCCAGTTTTTGGGAGGAGGCCCTCATGGGTCAAGCCAGC
CTGTACCAGGATGGGGGGAGGGGGTTCCCAACCTAGGCCCCAGCCACCCAGACTCCCCCACCCCCACTCCCTTTTCCACTGCTCTGACCT

>56789_56789_6_MYO9B-DDA1_MYO9B_chr19_17213367_ENST00000595618_DDA1_chr19_17424832_ENST00000359866_length(amino acids)=381AA_BP=0
MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLL
WPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAG
SILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVER
TILGAGPVLEADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYO9B-DDA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000397274+1391739_1744280.02189.0RHOA
HgeneMYO9Bchr19:17213367chr19:17424831ENST00000595618+2401739_1744280.02458.6666666666665RHOA
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000397274+1391739_1744280.02189.0RHOA
HgeneMYO9Bchr19:17213367chr19:17424832ENST00000595618+2401739_1744280.02458.6666666666665RHOA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO9B-DDA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO9B-DDA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource