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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYRIP-MLH1 (FusionGDB2 ID:56853)

Fusion Gene Summary for MYRIP-MLH1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYRIP-MLH1
Fusion gene ID: 56853
HgeneTgene
Gene symbol

MYRIP

MLH1

Gene ID

25924

4292

Gene namemyosin VIIA and Rab interacting proteinmutL homolog 1
SynonymsSLAC2-C|SLAC2CCOCA2|FCC2|HNPCC|HNPCC2|hMLH1
Cytomap

3p22.1

3p22.2

Type of geneprotein-codingprotein-coding
Descriptionrab effector MyRIPSlp homologue lacking C2 domainsexophilin-8myosin-VIIa- and Rab-interacting proteinslp homolog lacking C2 domains csynaptotagmin-like protein homologue lacking C2 domains-csynaptotagmin-like protein lacking C2 domains CDNA mismatch repair protein Mlh1mutL homolog 1, colon cancer, nonpolyposis type 2
Modification date2020032020200327
UniProtAcc

Q8NFW9

P40692

Ensembl transtripts involved in fusion geneENST00000302541, ENST00000425621, 
ENST00000444716, ENST00000396217, 
ENST00000459828, ENST00000539167, 
ENST00000492474, ENST00000231790, 
ENST00000435176, ENST00000455445, 
ENST00000458205, ENST00000536378, 
ENST00000539477, 
Fusion gene scores* DoF score5 X 4 X 5=1008 X 18 X 5=720
# samples 620
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/720*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYRIP [Title/Abstract] AND MLH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYRIP(39942417)-MLH1(37089010), # samples:3
Anticipated loss of major functional domain due to fusion event.MYRIP-MLH1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MYRIP-MLH1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYRIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MLH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A5A1-01AMYRIPchr3

39942417

-MLH1chr3

37089010

+
ChimerDB4PRADTCGA-KK-A5A1-01AMYRIPchr3

39942417

+MLH1chr3

37089010

+
ChimerDB4PRADTCGA-KK-A5A1MYRIPchr3

39942417

+MLH1chr3

37089010

+
ChimerDB4PRADTCGA-KK-A5A1MYRIPchr3

39942417

+MLH1chr3

37090394

+
ChimerDB4PRADTCGA-KK-A5A1MYRIPchr3

39942417

+MLH1chr3

37090395

+


Top

Fusion Gene ORF analysis for MYRIP-MLH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302541ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37089010

+
5CDS-intronENST00000302541ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090394

+
5CDS-intronENST00000302541ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090395

+
5CDS-intronENST00000425621ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37089010

+
5CDS-intronENST00000425621ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090394

+
5CDS-intronENST00000425621ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090395

+
5CDS-intronENST00000444716ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37089010

+
5CDS-intronENST00000444716ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090394

+
5CDS-intronENST00000444716ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090395

+
5UTR-3CDSENST00000396217ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37089010

+
5UTR-3CDSENST00000396217ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090394

+
5UTR-3CDSENST00000396217ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090395

+
5UTR-3CDSENST00000396217ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37089010

+
5UTR-3CDSENST00000396217ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090394

+
5UTR-3CDSENST00000396217ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090395

+
5UTR-3CDSENST00000396217ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37089010

+
5UTR-3CDSENST00000396217ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090394

+
5UTR-3CDSENST00000396217ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090395

+
5UTR-3CDSENST00000396217ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37089010

+
5UTR-3CDSENST00000396217ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090394

+
5UTR-3CDSENST00000396217ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090395

+
5UTR-3CDSENST00000396217ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37089010

+
5UTR-3CDSENST00000396217ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090394

+
5UTR-3CDSENST00000396217ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090395

+
5UTR-3CDSENST00000396217ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37089010

+
5UTR-3CDSENST00000396217ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090394

+
5UTR-3CDSENST00000396217ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090395

+
5UTR-intronENST00000396217ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37089010

+
5UTR-intronENST00000396217ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090394

+
5UTR-intronENST00000396217ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000302541ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000302541ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000302541ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000302541ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000302541ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000302541ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000302541ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000302541ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000302541ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000302541ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000302541ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000302541ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000302541ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000302541ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000302541ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000302541ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000302541ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000302541ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000425621ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000425621ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000425621ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000425621ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000425621ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000425621ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000425621ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000425621ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000425621ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000425621ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000425621ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000425621ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000425621ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000425621ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000425621ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000425621ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000425621ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000425621ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000444716ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000444716ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000444716ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000444716ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000444716ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000444716ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000444716ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000444716ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000444716ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000444716ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000444716ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000444716ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000444716ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000444716ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000444716ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090395

+
Frame-shiftENST00000444716ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37089010

+
Frame-shiftENST00000444716ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090394

+
Frame-shiftENST00000444716ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000459828ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000459828ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000459828ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000459828ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000459828ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000459828ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000459828ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000459828ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000459828ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000459828ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000459828ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000459828ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000459828ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000459828ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000459828ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000459828ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000459828ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000459828ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000539167ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000539167ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000539167ENST00000231790MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000539167ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000539167ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000539167ENST00000435176MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000539167ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000539167ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000539167ENST00000455445MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000539167ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000539167ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000539167ENST00000458205MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000539167ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000539167ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000539167ENST00000536378MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-3CDSENST00000539167ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-3CDSENST00000539167ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-3CDSENST00000539167ENST00000539477MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-intronENST00000459828ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-intronENST00000459828ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-intronENST00000459828ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090395

+
intron-intronENST00000539167ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37089010

+
intron-intronENST00000539167ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090394

+
intron-intronENST00000539167ENST00000492474MYRIPchr3

39942417

+MLH1chr3

37090395

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MYRIP-MLH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MYRIP-MLH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39942417/:37089010)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYRIP

Q8NFW9

MLH1

P40692

FUNCTION: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.FUNCTION: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:20020535, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:9311737}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MYRIP-MLH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYRIP-MLH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYRIP-MLH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYRIP-MLH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource