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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABTB2-ATXN3 (FusionGDB2 ID:569)

Fusion Gene Summary for ABTB2-ATXN3

check button Fusion gene summary
Fusion gene informationFusion gene name: ABTB2-ATXN3
Fusion gene ID: 569
HgeneTgene
Gene symbol

ABTB2

ATXN3

Gene ID

25841

4287

Gene nameankyrin repeat and BTB domain containing 2ataxin 3
SynonymsABTB2A|BTBD22AT3|ATX3|JOS|MJD|MJD1|SCA3
Cytomap

11p13

14q32.12

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and BTB/POZ domain-containing protein 2ankyrin repeat and BTB (POZ) domain containing 2ataxin-3Machado-Joseph disease protein 1josephinolivopontocerebellar ataxia 3spinocerebellar ataxia type 3 protein
Modification date2020031320200313
UniProtAcc.

P54252

Ensembl transtripts involved in fusion geneENST00000298992, ENST00000435224, 
ENST00000530814, 		ENST00000554491, 
ENST00000340660, ENST00000502250, 
ENST00000503767, ENST00000532032, 
ENST00000393287, ENST00000429774, 
ENST00000545170, 
Fusion gene scores* DoF score13 X 10 X 3=3904 X 3 X 3=36
# samples 165
** MAII scorelog2(16/390*10)=-1.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABTB2 [Title/Abstract] AND ATXN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABTB2(34378248)-ATXN3(92563182), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATXN3

GO:0070536

protein K63-linked deubiquitination

22970133

TgeneATXN3

GO:0071108

protein K48-linked deubiquitination

22970133


check buttonFusion gene breakpoints across ABTB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATXN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0XU-01AABTB2chr11

34378248

-ATXN3chr14

92563182

-


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Fusion Gene ORF analysis for ABTB2-ATXN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000298992ENST00000554491ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-5UTRENST00000435224ENST00000554491ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000298992ENST00000340660ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000298992ENST00000502250ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000298992ENST00000503767ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000298992ENST00000532032ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000435224ENST00000340660ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000435224ENST00000502250ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000435224ENST00000503767ABTB2chr11

34378248

-ATXN3chr14

92563182

-
5CDS-intronENST00000435224ENST00000532032ABTB2chr11

34378248

-ATXN3chr14

92563182

-
In-frameENST00000298992ENST00000393287ABTB2chr11

34378248

-ATXN3chr14

92563182

-
In-frameENST00000298992ENST00000429774ABTB2chr11

34378248

-ATXN3chr14

92563182

-
In-frameENST00000298992ENST00000545170ABTB2chr11

34378248

-ATXN3chr14

92563182

-
In-frameENST00000435224ENST00000393287ABTB2chr11

34378248

-ATXN3chr14

92563182

-
In-frameENST00000435224ENST00000429774ABTB2chr11

34378248

-ATXN3chr14

92563182

-
In-frameENST00000435224ENST00000545170ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-3CDSENST00000530814ENST00000393287ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-3CDSENST00000530814ENST00000429774ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-3CDSENST00000530814ENST00000545170ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-5UTRENST00000530814ENST00000554491ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-intronENST00000530814ENST00000340660ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-intronENST00000530814ENST00000502250ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-intronENST00000530814ENST00000503767ABTB2chr11

34378248

-ATXN3chr14

92563182

-
intron-intronENST00000530814ENST00000532032ABTB2chr11

34378248

-ATXN3chr14

92563182

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000298992ABTB2chr1134378248-ENST00000545170ATXN3chr1492563182-74125554261643405
ENST00000298992ABTB2chr1134378248-ENST00000429774ATXN3chr1492563182-73645554261595389
ENST00000298992ABTB2chr1134378248-ENST00000393287ATXN3chr1492563182-51865554261616396
ENST00000435224ABTB2chr1134378248-ENST00000545170ATXN3chr1492563182-81651308591345428
ENST00000435224ABTB2chr1134378248-ENST00000429774ATXN3chr1492563182-81171308591345428
ENST00000435224ABTB2chr1134378248-ENST00000393287ATXN3chr1492563182-59391308591345428

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000298992ENST00000545170ABTB2chr1134378248-ATXN3chr1492563182-0.0002192780.9997807
ENST00000298992ENST00000429774ABTB2chr1134378248-ATXN3chr1492563182-0.0001782730.9998217
ENST00000298992ENST00000393287ABTB2chr1134378248-ATXN3chr1492563182-0.0003223490.99967766
ENST00000435224ENST00000545170ABTB2chr1134378248-ATXN3chr1492563182-0.0002981960.9997018
ENST00000435224ENST00000429774ABTB2chr1134378248-ATXN3chr1492563182-0.0002461290.9997539
ENST00000435224ENST00000393287ABTB2chr1134378248-ATXN3chr1492563182-0.0004887860.99951124

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Fusion Genomic Features for ABTB2-ATXN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABTB2-ATXN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:34378248/chr14:92563182)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATXN3

P54252

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATXN3chr11:34378248chr14:92563182ENST00000340660010292_3050307.0Compositional biasPoly-Gln
TgeneATXN3chr11:34378248chr14:92563182ENST00000393287011292_3058362.0Compositional biasPoly-Gln
TgeneATXN3chr11:34378248chr14:92563182ENST0000050225008292_3050183.0Compositional biasPoly-Gln
TgeneATXN3chr11:34378248chr14:92563182ENST00000503767010292_3058347.0Compositional biasPoly-Gln
TgeneATXN3chr11:34378248chr14:92563182ENST00000532032010292_3058365.0Compositional biasPoly-Gln
TgeneATXN3chr11:34378248chr14:92563182ENST000003406600101_1800307.0DomainJosephin
TgeneATXN3chr11:34378248chr14:92563182ENST00000340660010224_2430307.0DomainUIM 1
TgeneATXN3chr11:34378248chr14:92563182ENST00000340660010244_2630307.0DomainUIM 2
TgeneATXN3chr11:34378248chr14:92563182ENST00000340660010331_3490307.0DomainUIM 3
TgeneATXN3chr11:34378248chr14:92563182ENST00000393287011224_2438362.0DomainUIM 1
TgeneATXN3chr11:34378248chr14:92563182ENST00000393287011244_2638362.0DomainUIM 2
TgeneATXN3chr11:34378248chr14:92563182ENST00000393287011331_3498362.0DomainUIM 3
TgeneATXN3chr11:34378248chr14:92563182ENST00000502250081_1800183.0DomainJosephin
TgeneATXN3chr11:34378248chr14:92563182ENST0000050225008224_2430183.0DomainUIM 1
TgeneATXN3chr11:34378248chr14:92563182ENST0000050225008244_2630183.0DomainUIM 2
TgeneATXN3chr11:34378248chr14:92563182ENST0000050225008331_3490183.0DomainUIM 3
TgeneATXN3chr11:34378248chr14:92563182ENST00000503767010224_2438347.0DomainUIM 1
TgeneATXN3chr11:34378248chr14:92563182ENST00000503767010244_2638347.0DomainUIM 2
TgeneATXN3chr11:34378248chr14:92563182ENST00000503767010331_3498347.0DomainUIM 3
TgeneATXN3chr11:34378248chr14:92563182ENST00000532032010224_2438365.0DomainUIM 1
TgeneATXN3chr11:34378248chr14:92563182ENST00000532032010244_2638365.0DomainUIM 2
TgeneATXN3chr11:34378248chr14:92563182ENST00000532032010331_3498365.0DomainUIM 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABTB2chr11:34378248chr14:92563182ENST00000298992-117845_914108840.0DomainBTB
HgeneABTB2chr11:34378248chr14:92563182ENST00000435224-117845_9142941026.0DomainBTB
HgeneABTB2chr11:34378248chr14:92563182ENST00000298992-117521_550108840.0RepeatNote=ANK 1
HgeneABTB2chr11:34378248chr14:92563182ENST00000298992-117567_596108840.0RepeatNote=ANK 2
HgeneABTB2chr11:34378248chr14:92563182ENST00000298992-117606_635108840.0RepeatNote=ANK 3
HgeneABTB2chr11:34378248chr14:92563182ENST00000298992-117649_678108840.0RepeatNote=ANK 4
HgeneABTB2chr11:34378248chr14:92563182ENST00000435224-117521_5502941026.0RepeatNote=ANK 1
HgeneABTB2chr11:34378248chr14:92563182ENST00000435224-117567_5962941026.0RepeatNote=ANK 2
HgeneABTB2chr11:34378248chr14:92563182ENST00000435224-117606_6352941026.0RepeatNote=ANK 3
HgeneABTB2chr11:34378248chr14:92563182ENST00000435224-117649_6782941026.0RepeatNote=ANK 4
TgeneATXN3chr11:34378248chr14:92563182ENST000003932870111_1808362.0DomainJosephin
TgeneATXN3chr11:34378248chr14:92563182ENST000005037670101_1808347.0DomainJosephin
TgeneATXN3chr11:34378248chr14:92563182ENST000005320320101_1808365.0DomainJosephin


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Fusion Gene Sequence for ABTB2-ATXN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>569_569_1_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000298992_ATXN3_chr14_92563182_ENST00000393287_length(transcript)=5186nt_BP=555nt
AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG
CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC
TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC
GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT
CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG
GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG
GCAAGAACGCCAATGCAAGAAGGCTCACTTTGTGCTCAACATTGCCTGAATAACTTATTGCAAGGAGAATATTTTAGCCCTGTGGAATTA
TCCTCAATTGCACATCAGCTGGATGAGGAGGAGAGGATGAGAATGGCAGAAGGAGGAGTTACTAGTGAAGATTATCGCACGTTTTTACAG
CAGCCTTCTGGAAATATGGATGACAGTGGTTTTTTCTCTATTCAGGTTATAAGCAATGCCTTGAAAGTTTGGGGTTTAGAACTAATCCTG
TTCAACAGTCCAGAGTATCAGAGGCTCAGGATCGATCCTATAAATGAAAGATCATTTATATGCAATTATAAGGAACACTGGTTTACAGTT
AGAAAATTAGGAAAACAGTGGTTTAACTTGAATTCTCTCTTGACGGGTCCAGAATTAATATCAGATACATATCTTGCACTTTTCTTGGCT
CAATTACAACAGGAAGGTTATTCTATATTTGTCGTTAAGGGTGATCTGCCAGATTGCGAAGCTGACCAACTCCTGCAGATGATTAGGGTC
CAACAGATGCATCGACCAAAACTTATTGGAGAAGAATTAGCACAACTAAAAGAGCAAAGAGTCCATAAAACAGACCTGGAACGAGTGTTA
GAAGCAAATGATGGCTCAGGAATGTTAGACGAAGATGAGGAGGATTTGCAGAGGGCTCTGGCACTAAGTCGCCAAGAAATTGACATGGAA
GATGAGGAAGCAGATCTCCGCAGGGCTATTCAGCTAAGTATGCAAGGTAGTTCCAGAAACATATCTCAAGATATGACACAGACATCAGGT
ACAAATCTTACTTCAGAAGAGCTTCGGAAGAGACGAGAAGCCTACTTTGAAAAACAGCAGCAAAAGCAGCAACAGCAGCAGCAGCAGCAG
CAGCAGGGGGACCTATCAGGACAGAGTTCACATCCATGTGAAAGGCCAGCCACCAGTTCAGGAGCACTTGGGAGTGATCTAGGTGATGCT
ATGAGTGAAGAAGACATGCTTCAGGCAGCTGTGACCATGTCTTTAGAAACTGTCAGAAATGATTTGAAAACAGAAGGAAAAAAATAATAC
CTTTAAAAAATAATTTAGATATTCATACTTTCCAACATTATCCTGTGTGATTACAGCATAGGGTCCACTTTGGTAATGTGTCAAAGAGAT
GAGGAAATAAGACTTTTAGCGGTTTGCAAACAAAATGATGGGAAAGTGGAACAATGCGTCGGTTGTAGGACTAAATAATGATCTTCCAAA
TATTAGCCAAAGAGGCATTCAGCAATTAAAGACATTTAAAATAGTTTTCTAAATGTTTCTTTTTCTTTTTTGAGTGTGCAATATGTAACA
TGTCTAAAGTTAGGGCATTTTTCTTGGATCTTTTTGCAGACTAGCTAATTAGCTCTCGCCTCAGGCTTTTTCCATATAGTTTGTTTTCTT
TTTCTGTCTTGTAGGTAAGTTGGCTCACATCATGTAATAGTGGCTTTCATTTCTTATTAACCAAATTAACCTTTCAGGAAAGTATCTCTA
CTTTCCTGATGTTGATAATAGTAATGGTTCTAGAAGGATGAACAGTTCTCCCTTCAACTGTATACCGTGTGCTCCAGTGTTTTCTTGTGT
TGTTTTCTCTGATCACAACTTTTCTGCTACCTGGTTTTCATTATTTTCCCACAATTCTTTTGAAAGATGGTAATCTTTTCTGAGGTTTAG
CGTTTTAAGCCCTACGATGGGATCATTATTTCATGACTGGTGCGTTCCTAAACTCTGAAATCAGCCTTGCACAAGTACTTGAGAATAAAT
GAGCATTTTTTAAAATGTGTGAGCATGTGCTTTCCCAGATGCTTTATGAATGTCTTTTCACTTATATCAAAACCTTACAGCTTTGTTGCA
ACCCCTTCTTCCTGCGCCTTATTTTTTCCTTTCTTCTCCAATTGAGAAAACTAGGAGAAGCATAGTATGCAGGCAAGTCTCCTTCTGTTA
GAAGACTAAACATACGTACCCACCATGAATGTATGATACATGAAATTTGGCCTTCAATTTTAATAGCAGTTTTATTTTATTTTTTCTCCT
ATGACTGGAGCTTTGTGTTCTCTTTACAGTTGAGTCATGGAATGTAGGTGTCTGCTTCACATCTTTTAGTAGGTATAGCTTGTCAAAGAT
GGTGATCTGGAACATGAAAATAATTTACTAATGAAAATATGTTTAAATTTATACTGTGATTTGACACTTGCATCATGTTTAGATAGCTTA
AGAACAATGGAAGTCACAGTACTTAGTGGATCTATAAATAAGAAAGTCCATAGTTTTGATAAATATTCTCTTTAATTGAGATGTACAGAG
AGTTTCTTGCTGGGTCAATAGGATAGTATCATTTTGGTGAAAACCATGTCTCTGAAATTGATGTTTTAGTTTCAGTGTTCCCTATCCCTC
ATTCTCCATCTCCTTTTGAAGCTCTTTTGAATGTTGAATTGTTCATAAGCTAAAATCCAAGAAATTTCAGCTGACAACTTCGAAAATTAT
AATATGGTATATTGCCCTCCTGGTGTGTGGCTGCACACATTTTATCAGGGAAAGTTTTTTGATCTAGGATTTATTGCTAACTAACTGAAA
AGAGAAGAAAAAATATCTTTTATTTATGATTATAAAATAGCTTTTTCTTCGATATAACAGATTTTTTAAGTCATTATTTTGTGCCAATCA
GTTTTCTGAAGTTTCCCTTACACAAAAGGATAGCTTTATTTTAAAATCTAAAGTTTCTTTTAATAGTTAAAAATGTTTCAGAAGAATTAT
AAAACTTTAAAACTGCAAGGGATGTTGGAGTTTAGTACTACTCCCTCAAGATTTAAAAAGCTAAATATTTTAAGACTGAACATTTATGTT
AATTATTACCAGTGTGTTTGTCATATTTTCCATGGATATTTGTTCATTACCTTTTTCCATTGAAAAGTTACATTAAACTTTTCATACACT
TGAATTGATGAGCTACCTAATATAAAAATGAGAAAACCAATATGCATTTTAAAGTTTTAACTTTAGAGTTTATAAAGTTCATATATACCC
TAGTTAAAGCACTTAAGAAAATATGGCATGTTTGACTTTTAGTTCCTAGAGAGTTTTTGTTTTTGTTTTTGTTTTTTTTTGAGACGGAGT
CTTGCTATGTCTCCCAGGCTGGAGGGCAGTGGCATGATCTCGGCTCACTACAACTTCCACCTCCCGGGTTCAAGCAATTCTCCTGCCTCA
GCCTCCAGAGTAGCTGGGATTACAGGCGCCCACCACCACACCCGGCAGATTTTTGTATTTTTGGTAGAGACGCGGTTTCATCATGTTTGG
CCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACTGCGCCTG
GCCAGCTAGAGAGTTTTTAAAGCAGAGCTGAGCACACACTGGATGCGTTTGAATGTGTTTGTGTAGTTTGTTGTGAAATTGTTACATTTA
GCAGGCAGATCCAGAAGCACTAGTGAACTGTCATCTTGGTGGGGTTGGCTTAAATTTAATTGACTGTTTAGATTCCATTTCTTAATTGAT
TGGCCAGTATGAAAAGATGCCAGTGCAAGTAACCATAGTATCAAAAAAGTTAAAAATTATTCAAAGCTATAGTTTATACATCAGGTACTG
CCATTTACTGTAAACCACCTGCAAGAAAGTCAGGAACAACTAAATTCACAAGAACTGTCCTGCTAAGAAGTGTATTAAAGATTTCCATTT
TGTTTTACTAATTGGGAACATCTTAATGTTTAATATTTAAACTATTGGTATCATTTTTCTAATGTATAATTTGTATTACTGGGATCAAGT
ATGTACAGTGGTGATGCTAGTAGAAGTTTAAGCCTTGGAAATACCACTTTCATATTTTCAGATGTCATGGATTTAATGAGTAATTTATGT
TTTTAAAATTCAGAATAGTTAATCTCTGATCTAAAACCATCAATCTATGTTTTTTACGGTAATCATGTAAATATTTCAGTAATATAAACT
GTTTGAAAAGGCTGCTGCAGGTAAACTCTATACTAGGATCTTGGCCAAATAATTTACAATTCACAGAATATTTTATTTAAGGTGGTGCTT
TTTTTTTTTGTCCTTAAAACTTGATTTTTCTTAACTTTATTCATGATGCCAAAGTAAATGAGGAAAAAAACTCAAAACCAGTTGAGTATC
ATTGCAGACAAAACTACCAGTAGTCCATATTGTTTAATATTAAGTTGAATAAAATAAATTTTATTTCAGTCAGAGCCTAAATCACATTTT
GATTGTCTGAATTTTTGATACTATTTTTAAAATCATGCTAGTGGCGGCTGGGCGTGGTAGCTCACGCCTGTAATCCCAGCATTTTGGGAG
GCCGAAGTGGGTGGATCACGAGGTCGGGAGTTCGAGACCAGCTTGGCCAAAATGGTGAAACCCCATCTGTACTAAAAACTACAAAAATTA
GCTGGGCGCGGTGGCAGGTGCCTGTAATCCCAGCTACCTGGGAGTCTGAGGCAGGAGAATTGCTTGAACCCTGGCGACAGAGGATGCAGT

>569_569_1_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000298992_ATXN3_chr14_92563182_ENST00000393287_length(amino acids)=396AA_BP=43
MMAEGPEAGRCLLRPWRWSSTTTPSSGASCSPMSISSAARTPMQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTS
EDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISD
TYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALAL
SRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGA

--------------------------------------------------------------
>569_569_2_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000298992_ATXN3_chr14_92563182_ENST00000429774_length(transcript)=7364nt_BP=555nt
AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG
CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC
TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC
GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT
CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG
GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG
GCAAGAACGCCAATGCAAGAAGGCTCACTTTGTGCTCAACATTGCCTGAATAACTTATTGCAAGGAGAATATTTTAGCCCTGTGGAATTA
TCCTCAATTGCACATCAGCTGGATGAGGAGGAGAGGATGAGAATGGCAGAAGGAGGAGTTACTAGTGAAGATTATCGCACGTTTTTACAG
GTTATAAGCAATGCCTTGAAAGTTTGGGGTTTAGAACTAATCCTGTTCAACAGTCCAGAGTATCAGAGGCTCAGGATCGATCCTATAAAT
GAAAGATCATTTATATGCAATTATAAGGAACACTGGTTTACAGTTAGAAAATTAGGAAAACAGTGGTTTAACTTGAATTCTCTCTTGACG
GGTCCAGAATTAATATCAGATACATATCTTGCACTTTTCTTGGCTCAATTACAACAGGAAGGTTATTCTATATTTGTCGTTAAGGGTGAT
CTGCCAGATTGCGAAGCTGACCAACTCCTGCAGATGATTAGGGTCCAACAGATGCATCGACCAAAACTTATTGGAGAAGAATTAGCACAA
CTAAAAGAGCAAAGAGTCCATAAAACAGACCTGGAACGAGTGTTAGAAGCAAATGATGGCTCAGGAATGTTAGACGAAGATGAGGAGGAT
TTGCAGAGGGCTCTGGCACTAAGTCGCCAAGAAATTGACATGGAAGATGAGGAAGCAGATCTCCGCAGGGCTATTCAGCTAAGTATGCAA
GGTAGTTCCAGAAACATATCTCAAGATATGACACAGACATCAGGTACAAATCTTACTTCAGAAGAGCTTCGGAAGAGACGAGAAGCCTAC
TTTGAAAAGGATCAGCACTTCCATATTTTAAAACAGCAGCAAAAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGGGGGACCTATCAGGA
CAGAGTTCACATCCATGTGAAAGGCCAGCCACCAGTTCAGGAGCACTTGGGAGTGATCTAGGTGATGCTATGAGTGAAGAAGACATGCTT
CAGGCAGCTGTGACCATGTCTTTAGAAACTGTCAGAAATGATTTGAAAACAGAAGGAAAAAAATAATACCTTTAAAAAATAATTTAGATA
TTCATACTTTCCAACATTATCCTGTGTGATTACAGCATAGGGTCCACTTTGGTAATGTGTCAAAGAGATGAGGAAATAAGACTTTTAGCG
GTTTGCAAACAAAATGATGGGAAAGTGGAACAATGCGTCGGTTGTAGGACTAAATAATGATCTTCCAAATATTAGCCAAAGAGGCATTCA
GCAATTAAAGACATTTAAAATAGTTTTCTAAATGTTTCTTTTTCTTTTTTGAGTGTGCAATATGTAACATGTCTAAAGTTAGGGCATTTT
TCTTGGATCTTTTTGCAGACTAGCTAATTAGCTCTCGCCTCAGGCTTTTTCCATATAGTTTGTTTTCTTTTTCTGTCTTGTAGGTAAGTT
GGCTCACATCATGTAATAGTGGCTTTCATTTCTTATTAACCAAATTAACCTTTCAGGAAAGTATCTCTACTTTCCTGATGTTGATAATAG
TAATGGTTCTAGAAGGATGAACAGTTCTCCCTTCAACTGTATACCGTGTGCTCCAGTGTTTTCTTGTGTTGTTTTCTCTGATCACAACTT
TTCTGCTACCTGGTTTTCATTATTTTCCCACAATTCTTTTGAAAGATGGTAATCTTTTCTGAGGTTTAGCGTTTTAAGCCCTACGATGGG
ATCATTATTTCATGACTGGTGCGTTCCTAAACTCTGAAATCAGCCTTGCACAAGTACTTGAGAATAAATGAGCATTTTTTAAAATGTGTG
AGCATGTGCTTTCCCAGATGCTTTATGAATGTCTTTTCACTTATATCAAAACCTTACAGCTTTGTTGCAACCCCTTCTTCCTGCGCCTTA
TTTTTTCCTTTCTTCTCCAATTGAGAAAACTAGGAGAAGCATAGTATGCAGGCAAGTCTCCTTCTGTTAGAAGACTAAACATACGTACCC
ACCATGAATGTATGATACATGAAATTTGGCCTTCAATTTTAATAGCAGTTTTATTTTATTTTTTCTCCTATGACTGGAGCTTTGTGTTCT
CTTTACAGTTGAGTCATGGAATGTAGGTGTCTGCTTCACATCTTTTAGTAGGTATAGCTTGTCAAAGATGGTGATCTGGAACATGAAAAT
AATTTACTAATGAAAATATGTTTAAATTTATACTGTGATTTGACACTTGCATCATGTTTAGATAGCTTAAGAACAATGGAAGTCACAGTA
CTTAGTGGATCTATAAATAAGAAAGTCCATAGTTTTGATAAATATTCTCTTTAATTGAGATGTACAGAGAGTTTCTTGCTGGGTCAATAG
GATAGTATCATTTTGGTGAAAACCATGTCTCTGAAATTGATGTTTTAGTTTCAGTGTTCCCTATCCCTCATTCTCCATCTCCTTTTGAAG
CTCTTTTGAATGTTGAATTGTTCATAAGCTAAAATCCAAGAAATTTCAGCTGACAACTTCGAAAATTATAATATGGTATATTGCCCTCCT
GGTGTGTGGCTGCACACATTTTATCAGGGAAAGTTTTTTGATCTAGGATTTATTGCTAACTAACTGAAAAGAGAAGAAAAAATATCTTTT
ATTTATGATTATAAAATAGCTTTTTCTTCGATATAACAGATTTTTTAAGTCATTATTTTGTGCCAATCAGTTTTCTGAAGTTTCCCTTAC
ACAAAAGGATAGCTTTATTTTAAAATCTAAAGTTTCTTTTAATAGTTAAAAATGTTTCAGAAGAATTATAAAACTTTAAAACTGCAAGGG
ATGTTGGAGTTTAGTACTACTCCCTCAAGATTTAAAAAGCTAAATATTTTAAGACTGAACATTTATGTTAATTATTACCAGTGTGTTTGT
CATATTTTCCATGGATATTTGTTCATTACCTTTTTCCATTGAAAAGTTACATTAAACTTTTCATACACTTGAATTGATGAGCTACCTAAT
ATAAAAATGAGAAAACCAATATGCATTTTAAAGTTTTAACTTTAGAGTTTATAAAGTTCATATATACCCTAGTTAAAGCACTTAAGAAAA
TATGGCATGTTTGACTTTTAGTTCCTAGAGAGTTTTTGTTTTTGTTTTTGTTTTTTTTTGAGACGGAGTCTTGCTATGTCTCCCAGGCTG
GAGGGCAGTGGCATGATCTCGGCTCACTACAACTTCCACCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATT
ACAGGCGCCCACCACCACACCCGGCAGATTTTTGTATTTTTGGTAGAGACGCGGTTTCATCATGTTTGGCCAGGCTGGTCTCGAACTCCT
GACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACTGCGCCTGGCCAGCTAGAGAGTTTTTAAA
GCAGAGCTGAGCACACACTGGATGCGTTTGAATGTGTTTGTGTAGTTTGTTGTGAAATTGTTACATTTAGCAGGCAGATCCAGAAGCACT
AGTGAACTGTCATCTTGGTGGGGTTGGCTTAAATTTAATTGACTGTTTAGATTCCATTTCTTAATTGATTGGCCAGTATGAAAAGATGCC
AGTGCAAGTAACCATAGTATCAAAAAAGTTAAAAATTATTCAAAGCTATAGTTTATACATCAGGTACTGCCATTTACTGTAAACCACCTG
CAAGAAAGTCAGGAACAACTAAATTCACAAGAACTGTCCTGCTAAGAAGTGTATTAAAGATTTCCATTTTGTTTTACTAATTGGGAACAT
CTTAATGTTTAATATTTAAACTATTGGTATCATTTTTCTAATGTATAATTTGTATTACTGGGATCAAGTATGTACAGTGGTGATGCTAGT
AGAAGTTTAAGCCTTGGAAATACCACTTTCATATTTTCAGATGTCATGGATTTAATGAGTAATTTATGTTTTTAAAATTCAGAATAGTTA
ATCTCTGATCTAAAACCATCAATCTATGTTTTTTACGGTAATCATGTAAATATTTCAGTAATATAAACTGTTTGAAAAGGCTGCTGCAGG
TAAACTCTATACTAGGATCTTGGCCAAATAATTTACAATTCACAGAATATTTTATTTAAGGTGGTGCTTTTTTTTTTTGTCCTTAAAACT
TGATTTTTCTTAACTTTATTCATGATGCCAAAGTAAATGAGGAAAAAAACTCAAAACCAGTTGAGTATCATTGCAGACAAAACTACCAGT
AGTCCATATTGTTTAATATTAAGTTGAATAAAATAAATTTTATTTCAGTCAGAGCCTAAATCACATTTTGATTGTCTGAATTTTTGATAC
TATTTTTAAAATCATGCTAGTGGCGGCTGGGCGTGGTAGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAAGTGGGTGGATCACGA
GGTCGGGAGTTCGAGACCAGCTTGGCCAAAATGGTGAAACCCCATCTGTACTAAAAACTACAAAAATTAGCTGGGCGCGGTGGCAGGTGC
CTGTAATCCCAGCTACCTGGGAGTCTGAGGCAGGAGAATTGCTTGAACCCTGGCGACAGAGGATGCAGTGAGCCAAGATGGTGCCACTGT
ACTCCAGACTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAATCATGCTAGTGCCAAGAGCTACTAAATTCTTAAAACCGG
CCCATTGGACCTGTACAGATAAAAAATAGATTCAGTGCATAATCAAAATATGATAATTTTAAAATCTTAAGTAGAAAAATAAATCTTGAT
GTTTTAAATTCTTACGAGGATTCAATAGTTAATATTGATGATCTCCCGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCAGTTCTGG
AGGCTGAGGTGGGCGAATCACTTCAGGCCAGGAGTTCAAGACCAGTCTGGGCAACATGGTGAAACCTCGTTTCTACTAAAAATACAAAAA
TTAGCCGGGCGTGGTTGCACACACTTGTAATCCCAGCTACTCAGGAGGCTAAGAATCGCATGAGCCTAGGAGGCAGAGGTTGCAGAGTGC
CAAGGGCTCACCACTGCATTCCAGCCTGCCCAACAGAGTGAGACACTGTTTCTGAAAAAAAAAAATATATATATATATATATATATGTGT
GTATATATATATGTATATATATATGACTTCCTATTAAAAACTTTATCCCAGTCGGGGGCAGTGGCTCACGCCTGTAATCCCAACACTTTG
GGAGGCTGAGGCAGGTGGATCACCTGAAGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAA
ACTTAAGCCAGGTATGGTGGCGGGCACCTGTAATCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATCGTTTAAACCCAGGAGGTGGAGGT
TGCAGTGAGCTGAGATCGTGCCATTGCACTCTAGCCTGGGCAACAAGAGTAAAACTCCATCTTAAAGGTTTGTTTGTTTTTTTTTAATCC
GGAAACGAAGAGGCGTTGGGCCGCTATTTTCTTTTTCTTTCTTTCTTTCTTTCTTTTTTTTTTTTTCTGAGACGGAGTCTAGCTCTGCTG
CCCAGGCTGGAGTACAATGACACGATGTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTA
CCTGGGATTACAGGCACCTGCCACTACACCTGGCGAATATTTGTTTTTTTTAGTAGAGACGGGCTTTTACCATGTTAGGCTGGTCTCAAA
CTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGCAGGCCACCACACCCGGCCTTGGGCCACTGTT
TTCAAAGTGAATTGTTTGTTGTATCGAGTCCTTAAGTATGGATATATATGTGACCCTAATTAAGAACTACCAGATTGGATCAACTAATCA
TGTCAGCAATGTAAATAACTTTATTTTTCATATTCAAAATAAAAACTTTCTTTTATTTCTGGCCCCTTTATAACCAGCATCTTTTTGCTT
TAAAAAATGACCTGGCTTTGTATTTTTTTAGTCTTAAACATAATAAAAATATTTTTGTTCTAATTTGCTTTCATGAGTGAAGATTATTGA
CATCGTTGGTAAATTCTAGAATTTTGATTTTGTTTTTTAATTTGAAGAAAATCTTTGCTATTATTATTTTTTCCAAGTGGTCTGGCATTT
TAAGAATTAGTGCTAATAACGTAACTTCTAAATTTGTCGTAATTGGCATGTTTAATAGCATATCAAAAAACATTTTAAGCCTGTGGATTC
ATAGACAAAGCAATGAGAAACATTAGTAAAATATAAATGGATATTCCTGATGCATTTAGGAAGCTCTCAATTGTCTCTTGCATAGTTCAA
GGAATGTTTTCTGAATTTTTTTAATGCTTTTTTTTTTTTTGAAAGAGGAAAACATACATTTTTAAATGTGATTATCTAATTTTTACAACA
CTGGGCTATTAGGAATAACTTTTTAAAAATTACTGTTCTGTATAAATATTTGAAATTCAAGTACAGAAAATATCTGAAACAAAAAGCATT
GTTGTTTGGCCATGATACAAGTGCACTGTGGCAGTGCCGCTTGCTCAGGACCCAGCCCTGCAGCCCTTCTGTGTGTGCTCCCTCGTTAAG
TTCATTTGCTGTTATTACACACACAGGCCTTCCTGTCTGGTCGTTAGAAAAGCCGGGCTTCCAAAGCACTGTTGAACACAGGATTCTGTT

>569_569_2_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000298992_ATXN3_chr14_92563182_ENST00000429774_length(amino acids)=389AA_BP=43
MMAEGPEAGRCLLRPWRWSSTTTPSSGASCSPMSISSAARTPMQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTS
EDYRTFLQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGY
SIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLR
RAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKDQHFHILKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGD

--------------------------------------------------------------
>569_569_3_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000298992_ATXN3_chr14_92563182_ENST00000545170_length(transcript)=7412nt_BP=555nt
AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG
CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC
TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC
GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT
CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG
GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG
GCAAGAACGCCAATGCAAGAAGGCTCACTTTGTGCTCAACATTGCCTGAATAACTTATTGCAAGGAGAATATTTTAGCCCTGTGGAATTA
TCCTCAATTGCACATCAGCTGGATGAGGAGGAGAGGATGAGAATGGCAGAAGGAGGAGTTACTAGTGAAGATTATCGCACGTTTTTACAG
CAGCCTTCTGGAAATATGGATGACAGTGGTTTTTTCTCTATTCAGGTTATAAGCAATGCCTTGAAAGTTTGGGGTTTAGAACTAATCCTG
TTCAACAGTCCAGAGTATCAGAGGCTCAGGATCGATCCTATAAATGAAAGATCATTTATATGCAATTATAAGGAACACTGGTTTACAGTT
AGAAAATTAGGAAAACAGTGGTTTAACTTGAATTCTCTCTTGACGGGTCCAGAATTAATATCAGATACATATCTTGCACTTTTCTTGGCT
CAATTACAACAGGAAGGTTATTCTATATTTGTCGTTAAGGGTGATCTGCCAGATTGCGAAGCTGACCAACTCCTGCAGATGATTAGGGTC
CAACAGATGCATCGACCAAAACTTATTGGAGAAGAATTAGCACAACTAAAAGAGCAAAGAGTCCATAAAACAGACCTGGAACGAGTGTTA
GAAGCAAATGATGGCTCAGGAATGTTAGACGAAGATGAGGAGGATTTGCAGAGGGCTCTGGCACTAAGTCGCCAAGAAATTGACATGGAA
GATGAGGAAGCAGATCTCCGCAGGGCTATTCAGCTAAGTATGCAAGGTAGTTCCAGAAACATATCTCAAGATATGACACAGACATCAGGT
ACAAATCTTACTTCAGAAGAGCTTCGGAAGAGACGAGAAGCCTACTTTGAAAAGATATACTTCACTTTTGAATGTTTCAGACAGCAGCAA
AAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGGGGGACCTATCAGGACAGAGTTCACATCCATGTGAAAGGCCAGCCACCAGTTCAGGA
GCACTTGGGAGTGATCTAGGTGATGCTATGAGTGAAGAAGACATGCTTCAGGCAGCTGTGACCATGTCTTTAGAAACTGTCAGAAATGAT
TTGAAAACAGAAGGAAAAAAATAATACCTTTAAAAAATAATTTAGATATTCATACTTTCCAACATTATCCTGTGTGATTACAGCATAGGG
TCCACTTTGGTAATGTGTCAAAGAGATGAGGAAATAAGACTTTTAGCGGTTTGCAAACAAAATGATGGGAAAGTGGAACAATGCGTCGGT
TGTAGGACTAAATAATGATCTTCCAAATATTAGCCAAAGAGGCATTCAGCAATTAAAGACATTTAAAATAGTTTTCTAAATGTTTCTTTT
TCTTTTTTGAGTGTGCAATATGTAACATGTCTAAAGTTAGGGCATTTTTCTTGGATCTTTTTGCAGACTAGCTAATTAGCTCTCGCCTCA
GGCTTTTTCCATATAGTTTGTTTTCTTTTTCTGTCTTGTAGGTAAGTTGGCTCACATCATGTAATAGTGGCTTTCATTTCTTATTAACCA
AATTAACCTTTCAGGAAAGTATCTCTACTTTCCTGATGTTGATAATAGTAATGGTTCTAGAAGGATGAACAGTTCTCCCTTCAACTGTAT
ACCGTGTGCTCCAGTGTTTTCTTGTGTTGTTTTCTCTGATCACAACTTTTCTGCTACCTGGTTTTCATTATTTTCCCACAATTCTTTTGA
AAGATGGTAATCTTTTCTGAGGTTTAGCGTTTTAAGCCCTACGATGGGATCATTATTTCATGACTGGTGCGTTCCTAAACTCTGAAATCA
GCCTTGCACAAGTACTTGAGAATAAATGAGCATTTTTTAAAATGTGTGAGCATGTGCTTTCCCAGATGCTTTATGAATGTCTTTTCACTT
ATATCAAAACCTTACAGCTTTGTTGCAACCCCTTCTTCCTGCGCCTTATTTTTTCCTTTCTTCTCCAATTGAGAAAACTAGGAGAAGCAT
AGTATGCAGGCAAGTCTCCTTCTGTTAGAAGACTAAACATACGTACCCACCATGAATGTATGATACATGAAATTTGGCCTTCAATTTTAA
TAGCAGTTTTATTTTATTTTTTCTCCTATGACTGGAGCTTTGTGTTCTCTTTACAGTTGAGTCATGGAATGTAGGTGTCTGCTTCACATC
TTTTAGTAGGTATAGCTTGTCAAAGATGGTGATCTGGAACATGAAAATAATTTACTAATGAAAATATGTTTAAATTTATACTGTGATTTG
ACACTTGCATCATGTTTAGATAGCTTAAGAACAATGGAAGTCACAGTACTTAGTGGATCTATAAATAAGAAAGTCCATAGTTTTGATAAA
TATTCTCTTTAATTGAGATGTACAGAGAGTTTCTTGCTGGGTCAATAGGATAGTATCATTTTGGTGAAAACCATGTCTCTGAAATTGATG
TTTTAGTTTCAGTGTTCCCTATCCCTCATTCTCCATCTCCTTTTGAAGCTCTTTTGAATGTTGAATTGTTCATAAGCTAAAATCCAAGAA
ATTTCAGCTGACAACTTCGAAAATTATAATATGGTATATTGCCCTCCTGGTGTGTGGCTGCACACATTTTATCAGGGAAAGTTTTTTGAT
CTAGGATTTATTGCTAACTAACTGAAAAGAGAAGAAAAAATATCTTTTATTTATGATTATAAAATAGCTTTTTCTTCGATATAACAGATT
TTTTAAGTCATTATTTTGTGCCAATCAGTTTTCTGAAGTTTCCCTTACACAAAAGGATAGCTTTATTTTAAAATCTAAAGTTTCTTTTAA
TAGTTAAAAATGTTTCAGAAGAATTATAAAACTTTAAAACTGCAAGGGATGTTGGAGTTTAGTACTACTCCCTCAAGATTTAAAAAGCTA
AATATTTTAAGACTGAACATTTATGTTAATTATTACCAGTGTGTTTGTCATATTTTCCATGGATATTTGTTCATTACCTTTTTCCATTGA
AAAGTTACATTAAACTTTTCATACACTTGAATTGATGAGCTACCTAATATAAAAATGAGAAAACCAATATGCATTTTAAAGTTTTAACTT
TAGAGTTTATAAAGTTCATATATACCCTAGTTAAAGCACTTAAGAAAATATGGCATGTTTGACTTTTAGTTCCTAGAGAGTTTTTGTTTT
TGTTTTTGTTTTTTTTTGAGACGGAGTCTTGCTATGTCTCCCAGGCTGGAGGGCAGTGGCATGATCTCGGCTCACTACAACTTCCACCTC
CCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGCGCCCACCACCACACCCGGCAGATTTTTGTATTTTTG
GTAGAGACGCGGTTTCATCATGTTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAGTGTTGG
GATTACAGGCATGAGCCACTGCGCCTGGCCAGCTAGAGAGTTTTTAAAGCAGAGCTGAGCACACACTGGATGCGTTTGAATGTGTTTGTG
TAGTTTGTTGTGAAATTGTTACATTTAGCAGGCAGATCCAGAAGCACTAGTGAACTGTCATCTTGGTGGGGTTGGCTTAAATTTAATTGA
CTGTTTAGATTCCATTTCTTAATTGATTGGCCAGTATGAAAAGATGCCAGTGCAAGTAACCATAGTATCAAAAAAGTTAAAAATTATTCA
AAGCTATAGTTTATACATCAGGTACTGCCATTTACTGTAAACCACCTGCAAGAAAGTCAGGAACAACTAAATTCACAAGAACTGTCCTGC
TAAGAAGTGTATTAAAGATTTCCATTTTGTTTTACTAATTGGGAACATCTTAATGTTTAATATTTAAACTATTGGTATCATTTTTCTAAT
GTATAATTTGTATTACTGGGATCAAGTATGTACAGTGGTGATGCTAGTAGAAGTTTAAGCCTTGGAAATACCACTTTCATATTTTCAGAT
GTCATGGATTTAATGAGTAATTTATGTTTTTAAAATTCAGAATAGTTAATCTCTGATCTAAAACCATCAATCTATGTTTTTTACGGTAAT
CATGTAAATATTTCAGTAATATAAACTGTTTGAAAAGGCTGCTGCAGGTAAACTCTATACTAGGATCTTGGCCAAATAATTTACAATTCA
CAGAATATTTTATTTAAGGTGGTGCTTTTTTTTTTTGTCCTTAAAACTTGATTTTTCTTAACTTTATTCATGATGCCAAAGTAAATGAGG
AAAAAAACTCAAAACCAGTTGAGTATCATTGCAGACAAAACTACCAGTAGTCCATATTGTTTAATATTAAGTTGAATAAAATAAATTTTA
TTTCAGTCAGAGCCTAAATCACATTTTGATTGTCTGAATTTTTGATACTATTTTTAAAATCATGCTAGTGGCGGCTGGGCGTGGTAGCTC
ACGCCTGTAATCCCAGCATTTTGGGAGGCCGAAGTGGGTGGATCACGAGGTCGGGAGTTCGAGACCAGCTTGGCCAAAATGGTGAAACCC
CATCTGTACTAAAAACTACAAAAATTAGCTGGGCGCGGTGGCAGGTGCCTGTAATCCCAGCTACCTGGGAGTCTGAGGCAGGAGAATTGC
TTGAACCCTGGCGACAGAGGATGCAGTGAGCCAAGATGGTGCCACTGTACTCCAGACTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAA
AAAAAAAAATCATGCTAGTGCCAAGAGCTACTAAATTCTTAAAACCGGCCCATTGGACCTGTACAGATAAAAAATAGATTCAGTGCATAA
TCAAAATATGATAATTTTAAAATCTTAAGTAGAAAAATAAATCTTGATGTTTTAAATTCTTACGAGGATTCAATAGTTAATATTGATGAT
CTCCCGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCAGTTCTGGAGGCTGAGGTGGGCGAATCACTTCAGGCCAGGAGTTCAAGAC
CAGTCTGGGCAACATGGTGAAACCTCGTTTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTTGCACACACTTGTAATCCCAGCTACTC
AGGAGGCTAAGAATCGCATGAGCCTAGGAGGCAGAGGTTGCAGAGTGCCAAGGGCTCACCACTGCATTCCAGCCTGCCCAACAGAGTGAG
ACACTGTTTCTGAAAAAAAAAAATATATATATATATATATATATGTGTGTATATATATATGTATATATATATGACTTCCTATTAAAAACT
TTATCCCAGTCGGGGGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAAGTCCGGAGTTTGAG
ACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAACTTAAGCCAGGTATGGTGGCGGGCACCTGTAATCCCAGTTA
CTTGGGAGGCTGAGGCAGGAGAATCGTTTAAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCGTGCCATTGCACTCTAGCCTGGGCA
ACAAGAGTAAAACTCCATCTTAAAGGTTTGTTTGTTTTTTTTTAATCCGGAAACGAAGAGGCGTTGGGCCGCTATTTTCTTTTTCTTTCT
TTCTTTCTTTCTTTTTTTTTTTTTCTGAGACGGAGTCTAGCTCTGCTGCCCAGGCTGGAGTACAATGACACGATGTTGGCTCACTGCAAC
CTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGATTACAGGCACCTGCCACTACACCTGGCGAATATTT
GTTTTTTTTAGTAGAGACGGGCTTTTACCATGTTAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGT
GCTGGGATTACAGGTGCAGGCCACCACACCCGGCCTTGGGCCACTGTTTTCAAAGTGAATTGTTTGTTGTATCGAGTCCTTAAGTATGGA
TATATATGTGACCCTAATTAAGAACTACCAGATTGGATCAACTAATCATGTCAGCAATGTAAATAACTTTATTTTTCATATTCAAAATAA
AAACTTTCTTTTATTTCTGGCCCCTTTATAACCAGCATCTTTTTGCTTTAAAAAATGACCTGGCTTTGTATTTTTTTAGTCTTAAACATA
ATAAAAATATTTTTGTTCTAATTTGCTTTCATGAGTGAAGATTATTGACATCGTTGGTAAATTCTAGAATTTTGATTTTGTTTTTTAATT
TGAAGAAAATCTTTGCTATTATTATTTTTTCCAAGTGGTCTGGCATTTTAAGAATTAGTGCTAATAACGTAACTTCTAAATTTGTCGTAA
TTGGCATGTTTAATAGCATATCAAAAAACATTTTAAGCCTGTGGATTCATAGACAAAGCAATGAGAAACATTAGTAAAATATAAATGGAT
ATTCCTGATGCATTTAGGAAGCTCTCAATTGTCTCTTGCATAGTTCAAGGAATGTTTTCTGAATTTTTTTAATGCTTTTTTTTTTTTTGA
AAGAGGAAAACATACATTTTTAAATGTGATTATCTAATTTTTACAACACTGGGCTATTAGGAATAACTTTTTAAAAATTACTGTTCTGTA
TAAATATTTGAAATTCAAGTACAGAAAATATCTGAAACAAAAAGCATTGTTGTTTGGCCATGATACAAGTGCACTGTGGCAGTGCCGCTT
GCTCAGGACCCAGCCCTGCAGCCCTTCTGTGTGTGCTCCCTCGTTAAGTTCATTTGCTGTTATTACACACACAGGCCTTCCTGTCTGGTC
GTTAGAAAAGCCGGGCTTCCAAAGCACTGTTGAACACAGGATTCTGTTGTTAGTGTGGATGTTCAATGAGTTGTATTTTAAATATCAAAG

>569_569_3_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000298992_ATXN3_chr14_92563182_ENST00000545170_length(amino acids)=405AA_BP=43
MMAEGPEAGRCLLRPWRWSSTTTPSSGASCSPMSISSAARTPMQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTS
EDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISD
TYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALAL
SRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKIYFTFECFRQQQKQQQQQQQQQQGDLSGQSSHPC

--------------------------------------------------------------
>569_569_4_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000435224_ATXN3_chr14_92563182_ENST00000393287_length(transcript)=5939nt_BP=1308nt
AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC
CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA
GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG
GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT
TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC
TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT
CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG
ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT
GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG
CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC
AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG
CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA
TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA
GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG
GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGCAAGAAGGCTCACTTTGTGCTCAACATTGCCTGAATAACTTA
TTGCAAGGAGAATATTTTAGCCCTGTGGAATTATCCTCAATTGCACATCAGCTGGATGAGGAGGAGAGGATGAGAATGGCAGAAGGAGGA
GTTACTAGTGAAGATTATCGCACGTTTTTACAGCAGCCTTCTGGAAATATGGATGACAGTGGTTTTTTCTCTATTCAGGTTATAAGCAAT
GCCTTGAAAGTTTGGGGTTTAGAACTAATCCTGTTCAACAGTCCAGAGTATCAGAGGCTCAGGATCGATCCTATAAATGAAAGATCATTT
ATATGCAATTATAAGGAACACTGGTTTACAGTTAGAAAATTAGGAAAACAGTGGTTTAACTTGAATTCTCTCTTGACGGGTCCAGAATTA
ATATCAGATACATATCTTGCACTTTTCTTGGCTCAATTACAACAGGAAGGTTATTCTATATTTGTCGTTAAGGGTGATCTGCCAGATTGC
GAAGCTGACCAACTCCTGCAGATGATTAGGGTCCAACAGATGCATCGACCAAAACTTATTGGAGAAGAATTAGCACAACTAAAAGAGCAA
AGAGTCCATAAAACAGACCTGGAACGAGTGTTAGAAGCAAATGATGGCTCAGGAATGTTAGACGAAGATGAGGAGGATTTGCAGAGGGCT
CTGGCACTAAGTCGCCAAGAAATTGACATGGAAGATGAGGAAGCAGATCTCCGCAGGGCTATTCAGCTAAGTATGCAAGGTAGTTCCAGA
AACATATCTCAAGATATGACACAGACATCAGGTACAAATCTTACTTCAGAAGAGCTTCGGAAGAGACGAGAAGCCTACTTTGAAAAACAG
CAGCAAAAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGGGGGACCTATCAGGACAGAGTTCACATCCATGTGAAAGGCCAGCCACCAGT
TCAGGAGCACTTGGGAGTGATCTAGGTGATGCTATGAGTGAAGAAGACATGCTTCAGGCAGCTGTGACCATGTCTTTAGAAACTGTCAGA
AATGATTTGAAAACAGAAGGAAAAAAATAATACCTTTAAAAAATAATTTAGATATTCATACTTTCCAACATTATCCTGTGTGATTACAGC
ATAGGGTCCACTTTGGTAATGTGTCAAAGAGATGAGGAAATAAGACTTTTAGCGGTTTGCAAACAAAATGATGGGAAAGTGGAACAATGC
GTCGGTTGTAGGACTAAATAATGATCTTCCAAATATTAGCCAAAGAGGCATTCAGCAATTAAAGACATTTAAAATAGTTTTCTAAATGTT
TCTTTTTCTTTTTTGAGTGTGCAATATGTAACATGTCTAAAGTTAGGGCATTTTTCTTGGATCTTTTTGCAGACTAGCTAATTAGCTCTC
GCCTCAGGCTTTTTCCATATAGTTTGTTTTCTTTTTCTGTCTTGTAGGTAAGTTGGCTCACATCATGTAATAGTGGCTTTCATTTCTTAT
TAACCAAATTAACCTTTCAGGAAAGTATCTCTACTTTCCTGATGTTGATAATAGTAATGGTTCTAGAAGGATGAACAGTTCTCCCTTCAA
CTGTATACCGTGTGCTCCAGTGTTTTCTTGTGTTGTTTTCTCTGATCACAACTTTTCTGCTACCTGGTTTTCATTATTTTCCCACAATTC
TTTTGAAAGATGGTAATCTTTTCTGAGGTTTAGCGTTTTAAGCCCTACGATGGGATCATTATTTCATGACTGGTGCGTTCCTAAACTCTG
AAATCAGCCTTGCACAAGTACTTGAGAATAAATGAGCATTTTTTAAAATGTGTGAGCATGTGCTTTCCCAGATGCTTTATGAATGTCTTT
TCACTTATATCAAAACCTTACAGCTTTGTTGCAACCCCTTCTTCCTGCGCCTTATTTTTTCCTTTCTTCTCCAATTGAGAAAACTAGGAG
AAGCATAGTATGCAGGCAAGTCTCCTTCTGTTAGAAGACTAAACATACGTACCCACCATGAATGTATGATACATGAAATTTGGCCTTCAA
TTTTAATAGCAGTTTTATTTTATTTTTTCTCCTATGACTGGAGCTTTGTGTTCTCTTTACAGTTGAGTCATGGAATGTAGGTGTCTGCTT
CACATCTTTTAGTAGGTATAGCTTGTCAAAGATGGTGATCTGGAACATGAAAATAATTTACTAATGAAAATATGTTTAAATTTATACTGT
GATTTGACACTTGCATCATGTTTAGATAGCTTAAGAACAATGGAAGTCACAGTACTTAGTGGATCTATAAATAAGAAAGTCCATAGTTTT
GATAAATATTCTCTTTAATTGAGATGTACAGAGAGTTTCTTGCTGGGTCAATAGGATAGTATCATTTTGGTGAAAACCATGTCTCTGAAA
TTGATGTTTTAGTTTCAGTGTTCCCTATCCCTCATTCTCCATCTCCTTTTGAAGCTCTTTTGAATGTTGAATTGTTCATAAGCTAAAATC
CAAGAAATTTCAGCTGACAACTTCGAAAATTATAATATGGTATATTGCCCTCCTGGTGTGTGGCTGCACACATTTTATCAGGGAAAGTTT
TTTGATCTAGGATTTATTGCTAACTAACTGAAAAGAGAAGAAAAAATATCTTTTATTTATGATTATAAAATAGCTTTTTCTTCGATATAA
CAGATTTTTTAAGTCATTATTTTGTGCCAATCAGTTTTCTGAAGTTTCCCTTACACAAAAGGATAGCTTTATTTTAAAATCTAAAGTTTC
TTTTAATAGTTAAAAATGTTTCAGAAGAATTATAAAACTTTAAAACTGCAAGGGATGTTGGAGTTTAGTACTACTCCCTCAAGATTTAAA
AAGCTAAATATTTTAAGACTGAACATTTATGTTAATTATTACCAGTGTGTTTGTCATATTTTCCATGGATATTTGTTCATTACCTTTTTC
CATTGAAAAGTTACATTAAACTTTTCATACACTTGAATTGATGAGCTACCTAATATAAAAATGAGAAAACCAATATGCATTTTAAAGTTT
TAACTTTAGAGTTTATAAAGTTCATATATACCCTAGTTAAAGCACTTAAGAAAATATGGCATGTTTGACTTTTAGTTCCTAGAGAGTTTT
TGTTTTTGTTTTTGTTTTTTTTTGAGACGGAGTCTTGCTATGTCTCCCAGGCTGGAGGGCAGTGGCATGATCTCGGCTCACTACAACTTC
CACCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGCGCCCACCACCACACCCGGCAGATTTTTGTA
TTTTTGGTAGAGACGCGGTTTCATCATGTTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAG
TGTTGGGATTACAGGCATGAGCCACTGCGCCTGGCCAGCTAGAGAGTTTTTAAAGCAGAGCTGAGCACACACTGGATGCGTTTGAATGTG
TTTGTGTAGTTTGTTGTGAAATTGTTACATTTAGCAGGCAGATCCAGAAGCACTAGTGAACTGTCATCTTGGTGGGGTTGGCTTAAATTT
AATTGACTGTTTAGATTCCATTTCTTAATTGATTGGCCAGTATGAAAAGATGCCAGTGCAAGTAACCATAGTATCAAAAAAGTTAAAAAT
TATTCAAAGCTATAGTTTATACATCAGGTACTGCCATTTACTGTAAACCACCTGCAAGAAAGTCAGGAACAACTAAATTCACAAGAACTG
TCCTGCTAAGAAGTGTATTAAAGATTTCCATTTTGTTTTACTAATTGGGAACATCTTAATGTTTAATATTTAAACTATTGGTATCATTTT
TCTAATGTATAATTTGTATTACTGGGATCAAGTATGTACAGTGGTGATGCTAGTAGAAGTTTAAGCCTTGGAAATACCACTTTCATATTT
TCAGATGTCATGGATTTAATGAGTAATTTATGTTTTTAAAATTCAGAATAGTTAATCTCTGATCTAAAACCATCAATCTATGTTTTTTAC
GGTAATCATGTAAATATTTCAGTAATATAAACTGTTTGAAAAGGCTGCTGCAGGTAAACTCTATACTAGGATCTTGGCCAAATAATTTAC
AATTCACAGAATATTTTATTTAAGGTGGTGCTTTTTTTTTTTGTCCTTAAAACTTGATTTTTCTTAACTTTATTCATGATGCCAAAGTAA
ATGAGGAAAAAAACTCAAAACCAGTTGAGTATCATTGCAGACAAAACTACCAGTAGTCCATATTGTTTAATATTAAGTTGAATAAAATAA
ATTTTATTTCAGTCAGAGCCTAAATCACATTTTGATTGTCTGAATTTTTGATACTATTTTTAAAATCATGCTAGTGGCGGCTGGGCGTGG
TAGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAAGTGGGTGGATCACGAGGTCGGGAGTTCGAGACCAGCTTGGCCAAAATGGTG
AAACCCCATCTGTACTAAAAACTACAAAAATTAGCTGGGCGCGGTGGCAGGTGCCTGTAATCCCAGCTACCTGGGAGTCTGAGGCAGGAG

>569_569_4_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000435224_ATXN3_chr14_92563182_ENST00000393287_length(amino acids)=428AA_BP=
MRRRLLLLPPPPCSPGIPSLWRTDSLLVGIRGGQGGVPGGSDGVLSSGSCESGRRERGAPAGHGSRPPSRGLRAGNAAAEPRDAERKEGG
PEGLELVSAHLGKRAWSCECPSLGDAALGRLPMAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYS
GSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSV
LHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENL

--------------------------------------------------------------
>569_569_5_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000435224_ATXN3_chr14_92563182_ENST00000429774_length(transcript)=8117nt_BP=1308nt
AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC
CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA
GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG
GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT
TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC
TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT
CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG
ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT
GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG
CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC
AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG
CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA
TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA
GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG
GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGCAAGAAGGCTCACTTTGTGCTCAACATTGCCTGAATAACTTA
TTGCAAGGAGAATATTTTAGCCCTGTGGAATTATCCTCAATTGCACATCAGCTGGATGAGGAGGAGAGGATGAGAATGGCAGAAGGAGGA
GTTACTAGTGAAGATTATCGCACGTTTTTACAGGTTATAAGCAATGCCTTGAAAGTTTGGGGTTTAGAACTAATCCTGTTCAACAGTCCA
GAGTATCAGAGGCTCAGGATCGATCCTATAAATGAAAGATCATTTATATGCAATTATAAGGAACACTGGTTTACAGTTAGAAAATTAGGA
AAACAGTGGTTTAACTTGAATTCTCTCTTGACGGGTCCAGAATTAATATCAGATACATATCTTGCACTTTTCTTGGCTCAATTACAACAG
GAAGGTTATTCTATATTTGTCGTTAAGGGTGATCTGCCAGATTGCGAAGCTGACCAACTCCTGCAGATGATTAGGGTCCAACAGATGCAT
CGACCAAAACTTATTGGAGAAGAATTAGCACAACTAAAAGAGCAAAGAGTCCATAAAACAGACCTGGAACGAGTGTTAGAAGCAAATGAT
GGCTCAGGAATGTTAGACGAAGATGAGGAGGATTTGCAGAGGGCTCTGGCACTAAGTCGCCAAGAAATTGACATGGAAGATGAGGAAGCA
GATCTCCGCAGGGCTATTCAGCTAAGTATGCAAGGTAGTTCCAGAAACATATCTCAAGATATGACACAGACATCAGGTACAAATCTTACT
TCAGAAGAGCTTCGGAAGAGACGAGAAGCCTACTTTGAAAAGGATCAGCACTTCCATATTTTAAAACAGCAGCAAAAGCAGCAACAGCAG
CAGCAGCAGCAGCAGCAGGGGGACCTATCAGGACAGAGTTCACATCCATGTGAAAGGCCAGCCACCAGTTCAGGAGCACTTGGGAGTGAT
CTAGGTGATGCTATGAGTGAAGAAGACATGCTTCAGGCAGCTGTGACCATGTCTTTAGAAACTGTCAGAAATGATTTGAAAACAGAAGGA
AAAAAATAATACCTTTAAAAAATAATTTAGATATTCATACTTTCCAACATTATCCTGTGTGATTACAGCATAGGGTCCACTTTGGTAATG
TGTCAAAGAGATGAGGAAATAAGACTTTTAGCGGTTTGCAAACAAAATGATGGGAAAGTGGAACAATGCGTCGGTTGTAGGACTAAATAA
TGATCTTCCAAATATTAGCCAAAGAGGCATTCAGCAATTAAAGACATTTAAAATAGTTTTCTAAATGTTTCTTTTTCTTTTTTGAGTGTG
CAATATGTAACATGTCTAAAGTTAGGGCATTTTTCTTGGATCTTTTTGCAGACTAGCTAATTAGCTCTCGCCTCAGGCTTTTTCCATATA
GTTTGTTTTCTTTTTCTGTCTTGTAGGTAAGTTGGCTCACATCATGTAATAGTGGCTTTCATTTCTTATTAACCAAATTAACCTTTCAGG
AAAGTATCTCTACTTTCCTGATGTTGATAATAGTAATGGTTCTAGAAGGATGAACAGTTCTCCCTTCAACTGTATACCGTGTGCTCCAGT
GTTTTCTTGTGTTGTTTTCTCTGATCACAACTTTTCTGCTACCTGGTTTTCATTATTTTCCCACAATTCTTTTGAAAGATGGTAATCTTT
TCTGAGGTTTAGCGTTTTAAGCCCTACGATGGGATCATTATTTCATGACTGGTGCGTTCCTAAACTCTGAAATCAGCCTTGCACAAGTAC
TTGAGAATAAATGAGCATTTTTTAAAATGTGTGAGCATGTGCTTTCCCAGATGCTTTATGAATGTCTTTTCACTTATATCAAAACCTTAC
AGCTTTGTTGCAACCCCTTCTTCCTGCGCCTTATTTTTTCCTTTCTTCTCCAATTGAGAAAACTAGGAGAAGCATAGTATGCAGGCAAGT
CTCCTTCTGTTAGAAGACTAAACATACGTACCCACCATGAATGTATGATACATGAAATTTGGCCTTCAATTTTAATAGCAGTTTTATTTT
ATTTTTTCTCCTATGACTGGAGCTTTGTGTTCTCTTTACAGTTGAGTCATGGAATGTAGGTGTCTGCTTCACATCTTTTAGTAGGTATAG
CTTGTCAAAGATGGTGATCTGGAACATGAAAATAATTTACTAATGAAAATATGTTTAAATTTATACTGTGATTTGACACTTGCATCATGT
TTAGATAGCTTAAGAACAATGGAAGTCACAGTACTTAGTGGATCTATAAATAAGAAAGTCCATAGTTTTGATAAATATTCTCTTTAATTG
AGATGTACAGAGAGTTTCTTGCTGGGTCAATAGGATAGTATCATTTTGGTGAAAACCATGTCTCTGAAATTGATGTTTTAGTTTCAGTGT
TCCCTATCCCTCATTCTCCATCTCCTTTTGAAGCTCTTTTGAATGTTGAATTGTTCATAAGCTAAAATCCAAGAAATTTCAGCTGACAAC
TTCGAAAATTATAATATGGTATATTGCCCTCCTGGTGTGTGGCTGCACACATTTTATCAGGGAAAGTTTTTTGATCTAGGATTTATTGCT
AACTAACTGAAAAGAGAAGAAAAAATATCTTTTATTTATGATTATAAAATAGCTTTTTCTTCGATATAACAGATTTTTTAAGTCATTATT
TTGTGCCAATCAGTTTTCTGAAGTTTCCCTTACACAAAAGGATAGCTTTATTTTAAAATCTAAAGTTTCTTTTAATAGTTAAAAATGTTT
CAGAAGAATTATAAAACTTTAAAACTGCAAGGGATGTTGGAGTTTAGTACTACTCCCTCAAGATTTAAAAAGCTAAATATTTTAAGACTG
AACATTTATGTTAATTATTACCAGTGTGTTTGTCATATTTTCCATGGATATTTGTTCATTACCTTTTTCCATTGAAAAGTTACATTAAAC
TTTTCATACACTTGAATTGATGAGCTACCTAATATAAAAATGAGAAAACCAATATGCATTTTAAAGTTTTAACTTTAGAGTTTATAAAGT
TCATATATACCCTAGTTAAAGCACTTAAGAAAATATGGCATGTTTGACTTTTAGTTCCTAGAGAGTTTTTGTTTTTGTTTTTGTTTTTTT
TTGAGACGGAGTCTTGCTATGTCTCCCAGGCTGGAGGGCAGTGGCATGATCTCGGCTCACTACAACTTCCACCTCCCGGGTTCAAGCAAT
TCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGCGCCCACCACCACACCCGGCAGATTTTTGTATTTTTGGTAGAGACGCGGTTT
CATCATGTTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAG
CCACTGCGCCTGGCCAGCTAGAGAGTTTTTAAAGCAGAGCTGAGCACACACTGGATGCGTTTGAATGTGTTTGTGTAGTTTGTTGTGAAA
TTGTTACATTTAGCAGGCAGATCCAGAAGCACTAGTGAACTGTCATCTTGGTGGGGTTGGCTTAAATTTAATTGACTGTTTAGATTCCAT
TTCTTAATTGATTGGCCAGTATGAAAAGATGCCAGTGCAAGTAACCATAGTATCAAAAAAGTTAAAAATTATTCAAAGCTATAGTTTATA
CATCAGGTACTGCCATTTACTGTAAACCACCTGCAAGAAAGTCAGGAACAACTAAATTCACAAGAACTGTCCTGCTAAGAAGTGTATTAA
AGATTTCCATTTTGTTTTACTAATTGGGAACATCTTAATGTTTAATATTTAAACTATTGGTATCATTTTTCTAATGTATAATTTGTATTA
CTGGGATCAAGTATGTACAGTGGTGATGCTAGTAGAAGTTTAAGCCTTGGAAATACCACTTTCATATTTTCAGATGTCATGGATTTAATG
AGTAATTTATGTTTTTAAAATTCAGAATAGTTAATCTCTGATCTAAAACCATCAATCTATGTTTTTTACGGTAATCATGTAAATATTTCA
GTAATATAAACTGTTTGAAAAGGCTGCTGCAGGTAAACTCTATACTAGGATCTTGGCCAAATAATTTACAATTCACAGAATATTTTATTT
AAGGTGGTGCTTTTTTTTTTTGTCCTTAAAACTTGATTTTTCTTAACTTTATTCATGATGCCAAAGTAAATGAGGAAAAAAACTCAAAAC
CAGTTGAGTATCATTGCAGACAAAACTACCAGTAGTCCATATTGTTTAATATTAAGTTGAATAAAATAAATTTTATTTCAGTCAGAGCCT
AAATCACATTTTGATTGTCTGAATTTTTGATACTATTTTTAAAATCATGCTAGTGGCGGCTGGGCGTGGTAGCTCACGCCTGTAATCCCA
GCATTTTGGGAGGCCGAAGTGGGTGGATCACGAGGTCGGGAGTTCGAGACCAGCTTGGCCAAAATGGTGAAACCCCATCTGTACTAAAAA
CTACAAAAATTAGCTGGGCGCGGTGGCAGGTGCCTGTAATCCCAGCTACCTGGGAGTCTGAGGCAGGAGAATTGCTTGAACCCTGGCGAC
AGAGGATGCAGTGAGCCAAGATGGTGCCACTGTACTCCAGACTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAATCATGC
TAGTGCCAAGAGCTACTAAATTCTTAAAACCGGCCCATTGGACCTGTACAGATAAAAAATAGATTCAGTGCATAATCAAAATATGATAAT
TTTAAAATCTTAAGTAGAAAAATAAATCTTGATGTTTTAAATTCTTACGAGGATTCAATAGTTAATATTGATGATCTCCCGGCTGGGTGC
AGTGGCTCACGCCTGTAATCCCAGCAGTTCTGGAGGCTGAGGTGGGCGAATCACTTCAGGCCAGGAGTTCAAGACCAGTCTGGGCAACAT
GGTGAAACCTCGTTTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTTGCACACACTTGTAATCCCAGCTACTCAGGAGGCTAAGAATC
GCATGAGCCTAGGAGGCAGAGGTTGCAGAGTGCCAAGGGCTCACCACTGCATTCCAGCCTGCCCAACAGAGTGAGACACTGTTTCTGAAA
AAAAAAAATATATATATATATATATATATGTGTGTATATATATATGTATATATATATGACTTCCTATTAAAAACTTTATCCCAGTCGGGG
GCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAAGTCCGGAGTTTGAGACCAGCCTGGCCAAC
ATGGTGAAACCCCATCTCTACTAAAAATACAAAACTTAAGCCAGGTATGGTGGCGGGCACCTGTAATCCCAGTTACTTGGGAGGCTGAGG
CAGGAGAATCGTTTAAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCGTGCCATTGCACTCTAGCCTGGGCAACAAGAGTAAAACTC
CATCTTAAAGGTTTGTTTGTTTTTTTTTAATCCGGAAACGAAGAGGCGTTGGGCCGCTATTTTCTTTTTCTTTCTTTCTTTCTTTCTTTT
TTTTTTTTTCTGAGACGGAGTCTAGCTCTGCTGCCCAGGCTGGAGTACAATGACACGATGTTGGCTCACTGCAACCTCCACCTCCTGGGT
TCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGATTACAGGCACCTGCCACTACACCTGGCGAATATTTGTTTTTTTTAGTAGA
GACGGGCTTTTACCATGTTAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGT
GCAGGCCACCACACCCGGCCTTGGGCCACTGTTTTCAAAGTGAATTGTTTGTTGTATCGAGTCCTTAAGTATGGATATATATGTGACCCT
AATTAAGAACTACCAGATTGGATCAACTAATCATGTCAGCAATGTAAATAACTTTATTTTTCATATTCAAAATAAAAACTTTCTTTTATT
TCTGGCCCCTTTATAACCAGCATCTTTTTGCTTTAAAAAATGACCTGGCTTTGTATTTTTTTAGTCTTAAACATAATAAAAATATTTTTG
TTCTAATTTGCTTTCATGAGTGAAGATTATTGACATCGTTGGTAAATTCTAGAATTTTGATTTTGTTTTTTAATTTGAAGAAAATCTTTG
CTATTATTATTTTTTCCAAGTGGTCTGGCATTTTAAGAATTAGTGCTAATAACGTAACTTCTAAATTTGTCGTAATTGGCATGTTTAATA
GCATATCAAAAAACATTTTAAGCCTGTGGATTCATAGACAAAGCAATGAGAAACATTAGTAAAATATAAATGGATATTCCTGATGCATTT
AGGAAGCTCTCAATTGTCTCTTGCATAGTTCAAGGAATGTTTTCTGAATTTTTTTAATGCTTTTTTTTTTTTTGAAAGAGGAAAACATAC
ATTTTTAAATGTGATTATCTAATTTTTACAACACTGGGCTATTAGGAATAACTTTTTAAAAATTACTGTTCTGTATAAATATTTGAAATT
CAAGTACAGAAAATATCTGAAACAAAAAGCATTGTTGTTTGGCCATGATACAAGTGCACTGTGGCAGTGCCGCTTGCTCAGGACCCAGCC
CTGCAGCCCTTCTGTGTGTGCTCCCTCGTTAAGTTCATTTGCTGTTATTACACACACAGGCCTTCCTGTCTGGTCGTTAGAAAAGCCGGG
CTTCCAAAGCACTGTTGAACACAGGATTCTGTTGTTAGTGTGGATGTTCAATGAGTTGTATTTTAAATATCAAAGATTATTAAATAAAGA

>569_569_5_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000435224_ATXN3_chr14_92563182_ENST00000429774_length(amino acids)=428AA_BP=
MRRRLLLLPPPPCSPGIPSLWRTDSLLVGIRGGQGGVPGGSDGVLSSGSCESGRRERGAPAGHGSRPPSRGLRAGNAAAEPRDAERKEGG
PEGLELVSAHLGKRAWSCECPSLGDAALGRLPMAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYS
GSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSV
LHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENL

--------------------------------------------------------------
>569_569_6_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000435224_ATXN3_chr14_92563182_ENST00000545170_length(transcript)=8165nt_BP=1308nt
AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC
CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA
GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG
GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT
TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC
TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT
CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG
ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT
GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG
CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC
AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG
CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA
TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA
GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG
GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGCAAGAAGGCTCACTTTGTGCTCAACATTGCCTGAATAACTTA
TTGCAAGGAGAATATTTTAGCCCTGTGGAATTATCCTCAATTGCACATCAGCTGGATGAGGAGGAGAGGATGAGAATGGCAGAAGGAGGA
GTTACTAGTGAAGATTATCGCACGTTTTTACAGCAGCCTTCTGGAAATATGGATGACAGTGGTTTTTTCTCTATTCAGGTTATAAGCAAT
GCCTTGAAAGTTTGGGGTTTAGAACTAATCCTGTTCAACAGTCCAGAGTATCAGAGGCTCAGGATCGATCCTATAAATGAAAGATCATTT
ATATGCAATTATAAGGAACACTGGTTTACAGTTAGAAAATTAGGAAAACAGTGGTTTAACTTGAATTCTCTCTTGACGGGTCCAGAATTA
ATATCAGATACATATCTTGCACTTTTCTTGGCTCAATTACAACAGGAAGGTTATTCTATATTTGTCGTTAAGGGTGATCTGCCAGATTGC
GAAGCTGACCAACTCCTGCAGATGATTAGGGTCCAACAGATGCATCGACCAAAACTTATTGGAGAAGAATTAGCACAACTAAAAGAGCAA
AGAGTCCATAAAACAGACCTGGAACGAGTGTTAGAAGCAAATGATGGCTCAGGAATGTTAGACGAAGATGAGGAGGATTTGCAGAGGGCT
CTGGCACTAAGTCGCCAAGAAATTGACATGGAAGATGAGGAAGCAGATCTCCGCAGGGCTATTCAGCTAAGTATGCAAGGTAGTTCCAGA
AACATATCTCAAGATATGACACAGACATCAGGTACAAATCTTACTTCAGAAGAGCTTCGGAAGAGACGAGAAGCCTACTTTGAAAAGATA
TACTTCACTTTTGAATGTTTCAGACAGCAGCAAAAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGGGGGACCTATCAGGACAGAGTTCA
CATCCATGTGAAAGGCCAGCCACCAGTTCAGGAGCACTTGGGAGTGATCTAGGTGATGCTATGAGTGAAGAAGACATGCTTCAGGCAGCT
GTGACCATGTCTTTAGAAACTGTCAGAAATGATTTGAAAACAGAAGGAAAAAAATAATACCTTTAAAAAATAATTTAGATATTCATACTT
TCCAACATTATCCTGTGTGATTACAGCATAGGGTCCACTTTGGTAATGTGTCAAAGAGATGAGGAAATAAGACTTTTAGCGGTTTGCAAA
CAAAATGATGGGAAAGTGGAACAATGCGTCGGTTGTAGGACTAAATAATGATCTTCCAAATATTAGCCAAAGAGGCATTCAGCAATTAAA
GACATTTAAAATAGTTTTCTAAATGTTTCTTTTTCTTTTTTGAGTGTGCAATATGTAACATGTCTAAAGTTAGGGCATTTTTCTTGGATC
TTTTTGCAGACTAGCTAATTAGCTCTCGCCTCAGGCTTTTTCCATATAGTTTGTTTTCTTTTTCTGTCTTGTAGGTAAGTTGGCTCACAT
CATGTAATAGTGGCTTTCATTTCTTATTAACCAAATTAACCTTTCAGGAAAGTATCTCTACTTTCCTGATGTTGATAATAGTAATGGTTC
TAGAAGGATGAACAGTTCTCCCTTCAACTGTATACCGTGTGCTCCAGTGTTTTCTTGTGTTGTTTTCTCTGATCACAACTTTTCTGCTAC
CTGGTTTTCATTATTTTCCCACAATTCTTTTGAAAGATGGTAATCTTTTCTGAGGTTTAGCGTTTTAAGCCCTACGATGGGATCATTATT
TCATGACTGGTGCGTTCCTAAACTCTGAAATCAGCCTTGCACAAGTACTTGAGAATAAATGAGCATTTTTTAAAATGTGTGAGCATGTGC
TTTCCCAGATGCTTTATGAATGTCTTTTCACTTATATCAAAACCTTACAGCTTTGTTGCAACCCCTTCTTCCTGCGCCTTATTTTTTCCT
TTCTTCTCCAATTGAGAAAACTAGGAGAAGCATAGTATGCAGGCAAGTCTCCTTCTGTTAGAAGACTAAACATACGTACCCACCATGAAT
GTATGATACATGAAATTTGGCCTTCAATTTTAATAGCAGTTTTATTTTATTTTTTCTCCTATGACTGGAGCTTTGTGTTCTCTTTACAGT
TGAGTCATGGAATGTAGGTGTCTGCTTCACATCTTTTAGTAGGTATAGCTTGTCAAAGATGGTGATCTGGAACATGAAAATAATTTACTA
ATGAAAATATGTTTAAATTTATACTGTGATTTGACACTTGCATCATGTTTAGATAGCTTAAGAACAATGGAAGTCACAGTACTTAGTGGA
TCTATAAATAAGAAAGTCCATAGTTTTGATAAATATTCTCTTTAATTGAGATGTACAGAGAGTTTCTTGCTGGGTCAATAGGATAGTATC
ATTTTGGTGAAAACCATGTCTCTGAAATTGATGTTTTAGTTTCAGTGTTCCCTATCCCTCATTCTCCATCTCCTTTTGAAGCTCTTTTGA
ATGTTGAATTGTTCATAAGCTAAAATCCAAGAAATTTCAGCTGACAACTTCGAAAATTATAATATGGTATATTGCCCTCCTGGTGTGTGG
CTGCACACATTTTATCAGGGAAAGTTTTTTGATCTAGGATTTATTGCTAACTAACTGAAAAGAGAAGAAAAAATATCTTTTATTTATGAT
TATAAAATAGCTTTTTCTTCGATATAACAGATTTTTTAAGTCATTATTTTGTGCCAATCAGTTTTCTGAAGTTTCCCTTACACAAAAGGA
TAGCTTTATTTTAAAATCTAAAGTTTCTTTTAATAGTTAAAAATGTTTCAGAAGAATTATAAAACTTTAAAACTGCAAGGGATGTTGGAG
TTTAGTACTACTCCCTCAAGATTTAAAAAGCTAAATATTTTAAGACTGAACATTTATGTTAATTATTACCAGTGTGTTTGTCATATTTTC
CATGGATATTTGTTCATTACCTTTTTCCATTGAAAAGTTACATTAAACTTTTCATACACTTGAATTGATGAGCTACCTAATATAAAAATG
AGAAAACCAATATGCATTTTAAAGTTTTAACTTTAGAGTTTATAAAGTTCATATATACCCTAGTTAAAGCACTTAAGAAAATATGGCATG
TTTGACTTTTAGTTCCTAGAGAGTTTTTGTTTTTGTTTTTGTTTTTTTTTGAGACGGAGTCTTGCTATGTCTCCCAGGCTGGAGGGCAGT
GGCATGATCTCGGCTCACTACAACTTCCACCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGCGCC
CACCACCACACCCGGCAGATTTTTGTATTTTTGGTAGAGACGCGGTTTCATCATGTTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGG
TGATCCGCCTGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACTGCGCCTGGCCAGCTAGAGAGTTTTTAAAGCAGAGCTG
AGCACACACTGGATGCGTTTGAATGTGTTTGTGTAGTTTGTTGTGAAATTGTTACATTTAGCAGGCAGATCCAGAAGCACTAGTGAACTG
TCATCTTGGTGGGGTTGGCTTAAATTTAATTGACTGTTTAGATTCCATTTCTTAATTGATTGGCCAGTATGAAAAGATGCCAGTGCAAGT
AACCATAGTATCAAAAAAGTTAAAAATTATTCAAAGCTATAGTTTATACATCAGGTACTGCCATTTACTGTAAACCACCTGCAAGAAAGT
CAGGAACAACTAAATTCACAAGAACTGTCCTGCTAAGAAGTGTATTAAAGATTTCCATTTTGTTTTACTAATTGGGAACATCTTAATGTT
TAATATTTAAACTATTGGTATCATTTTTCTAATGTATAATTTGTATTACTGGGATCAAGTATGTACAGTGGTGATGCTAGTAGAAGTTTA
AGCCTTGGAAATACCACTTTCATATTTTCAGATGTCATGGATTTAATGAGTAATTTATGTTTTTAAAATTCAGAATAGTTAATCTCTGAT
CTAAAACCATCAATCTATGTTTTTTACGGTAATCATGTAAATATTTCAGTAATATAAACTGTTTGAAAAGGCTGCTGCAGGTAAACTCTA
TACTAGGATCTTGGCCAAATAATTTACAATTCACAGAATATTTTATTTAAGGTGGTGCTTTTTTTTTTTGTCCTTAAAACTTGATTTTTC
TTAACTTTATTCATGATGCCAAAGTAAATGAGGAAAAAAACTCAAAACCAGTTGAGTATCATTGCAGACAAAACTACCAGTAGTCCATAT
TGTTTAATATTAAGTTGAATAAAATAAATTTTATTTCAGTCAGAGCCTAAATCACATTTTGATTGTCTGAATTTTTGATACTATTTTTAA
AATCATGCTAGTGGCGGCTGGGCGTGGTAGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAAGTGGGTGGATCACGAGGTCGGGAG
TTCGAGACCAGCTTGGCCAAAATGGTGAAACCCCATCTGTACTAAAAACTACAAAAATTAGCTGGGCGCGGTGGCAGGTGCCTGTAATCC
CAGCTACCTGGGAGTCTGAGGCAGGAGAATTGCTTGAACCCTGGCGACAGAGGATGCAGTGAGCCAAGATGGTGCCACTGTACTCCAGAC
TGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAATCATGCTAGTGCCAAGAGCTACTAAATTCTTAAAACCGGCCCATTGGA
CCTGTACAGATAAAAAATAGATTCAGTGCATAATCAAAATATGATAATTTTAAAATCTTAAGTAGAAAAATAAATCTTGATGTTTTAAAT
TCTTACGAGGATTCAATAGTTAATATTGATGATCTCCCGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCAGTTCTGGAGGCTGAGG
TGGGCGAATCACTTCAGGCCAGGAGTTCAAGACCAGTCTGGGCAACATGGTGAAACCTCGTTTCTACTAAAAATACAAAAATTAGCCGGG
CGTGGTTGCACACACTTGTAATCCCAGCTACTCAGGAGGCTAAGAATCGCATGAGCCTAGGAGGCAGAGGTTGCAGAGTGCCAAGGGCTC
ACCACTGCATTCCAGCCTGCCCAACAGAGTGAGACACTGTTTCTGAAAAAAAAAAATATATATATATATATATATATGTGTGTATATATA
TATGTATATATATATGACTTCCTATTAAAAACTTTATCCCAGTCGGGGGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGA
GGCAGGTGGATCACCTGAAGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAACTTAAGCC
AGGTATGGTGGCGGGCACCTGTAATCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATCGTTTAAACCCAGGAGGTGGAGGTTGCAGTGAG
CTGAGATCGTGCCATTGCACTCTAGCCTGGGCAACAAGAGTAAAACTCCATCTTAAAGGTTTGTTTGTTTTTTTTTAATCCGGAAACGAA
GAGGCGTTGGGCCGCTATTTTCTTTTTCTTTCTTTCTTTCTTTCTTTTTTTTTTTTTCTGAGACGGAGTCTAGCTCTGCTGCCCAGGCTG
GAGTACAATGACACGATGTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGATT
ACAGGCACCTGCCACTACACCTGGCGAATATTTGTTTTTTTTAGTAGAGACGGGCTTTTACCATGTTAGGCTGGTCTCAAACTCCTGACC
TCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGCAGGCCACCACACCCGGCCTTGGGCCACTGTTTTCAAAGTG
AATTGTTTGTTGTATCGAGTCCTTAAGTATGGATATATATGTGACCCTAATTAAGAACTACCAGATTGGATCAACTAATCATGTCAGCAA
TGTAAATAACTTTATTTTTCATATTCAAAATAAAAACTTTCTTTTATTTCTGGCCCCTTTATAACCAGCATCTTTTTGCTTTAAAAAATG
ACCTGGCTTTGTATTTTTTTAGTCTTAAACATAATAAAAATATTTTTGTTCTAATTTGCTTTCATGAGTGAAGATTATTGACATCGTTGG
TAAATTCTAGAATTTTGATTTTGTTTTTTAATTTGAAGAAAATCTTTGCTATTATTATTTTTTCCAAGTGGTCTGGCATTTTAAGAATTA
GTGCTAATAACGTAACTTCTAAATTTGTCGTAATTGGCATGTTTAATAGCATATCAAAAAACATTTTAAGCCTGTGGATTCATAGACAAA
GCAATGAGAAACATTAGTAAAATATAAATGGATATTCCTGATGCATTTAGGAAGCTCTCAATTGTCTCTTGCATAGTTCAAGGAATGTTT
TCTGAATTTTTTTAATGCTTTTTTTTTTTTTGAAAGAGGAAAACATACATTTTTAAATGTGATTATCTAATTTTTACAACACTGGGCTAT
TAGGAATAACTTTTTAAAAATTACTGTTCTGTATAAATATTTGAAATTCAAGTACAGAAAATATCTGAAACAAAAAGCATTGTTGTTTGG
CCATGATACAAGTGCACTGTGGCAGTGCCGCTTGCTCAGGACCCAGCCCTGCAGCCCTTCTGTGTGTGCTCCCTCGTTAAGTTCATTTGC
TGTTATTACACACACAGGCCTTCCTGTCTGGTCGTTAGAAAAGCCGGGCTTCCAAAGCACTGTTGAACACAGGATTCTGTTGTTAGTGTG

>569_569_6_ABTB2-ATXN3_ABTB2_chr11_34378248_ENST00000435224_ATXN3_chr14_92563182_ENST00000545170_length(amino acids)=428AA_BP=
MRRRLLLLPPPPCSPGIPSLWRTDSLLVGIRGGQGGVPGGSDGVLSSGSCESGRRERGAPAGHGSRPPSRGLRAGNAAAEPRDAERKEGG
PEGLELVSAHLGKRAWSCECPSLGDAALGRLPMAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYS
GSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSV
LHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENL

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Fusion Gene PPI Analysis for ABTB2-ATXN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABTB2-ATXN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABTB2-ATXN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource