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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APPL2-NR0B1 (FusionGDB2 ID:5690)

Fusion Gene Summary for APPL2-NR0B1

check button Fusion gene summary
Fusion gene informationFusion gene name: APPL2-NR0B1
Fusion gene ID: 5690
HgeneTgene
Gene symbol

APPL2

NR0B1

Gene ID

55198

190

Gene nameadaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2nuclear receptor subfamily 0 group B member 1
SynonymsDIP13BAHC|AHCH|AHX|DAX-1|DAX1|DSS|GTD|HHG|NROB1|SRXY2
Cytomap

12q23.3

Xp21.2

Type of geneprotein-codingprotein-coding
DescriptionDCC-interacting protein 13-betaDIP13 betaadapter protein containing PH domain, PTB domain and leucine zipper motif 2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2nuclear receptor subfamily 0 group B member 1DSS-AHC critical region on the X chromosome protein 1nuclear hormone receptornuclear receptor DAX-1truncated nuclear receptor subfamily 0 group B member 1
Modification date2020031320200313
UniProtAcc

Q8NEU8

.
Ensembl transtripts involved in fusion geneENST00000258530, ENST00000539978, 
ENST00000551662, ENST00000549573, 
ENST00000546731, 		ENST00000378963, 
ENST00000453287, ENST00000378970, 
Fusion gene scores* DoF score9 X 10 X 5=4502 X 1 X 2=4
# samples 103
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/4*10)=2.90689059560852
Context

PubMed: APPL2 [Title/Abstract] AND NR0B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPPL2(105597481)-NR0B1(30322940), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPPL2

GO:0006606

protein import into nucleus

26583432

HgeneAPPL2

GO:0051289

protein homotetramerization

23055524

HgeneAPPL2

GO:2000045

regulation of G1/S transition of mitotic cell cycle

15016378

TgeneNR0B1

GO:0006694

steroid biosynthetic process

9384387

TgeneNR0B1

GO:0008104

protein localization

11875111

TgeneNR0B1

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

11875111

TgeneNR0B1

GO:0045892

negative regulation of transcription, DNA-templated

7990953|9384387


check buttonFusion gene breakpoints across APPL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NR0B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3BD-01AAPPL2chr12

105597481

-NR0B1chrX

30322940

-


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Fusion Gene ORF analysis for APPL2-NR0B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000258530ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000258530ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000539978ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000539978ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000551662ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5CDS-intronENST00000551662ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
5UTR-3CDSENST00000549573ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
5UTR-intronENST00000549573ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
5UTR-intronENST00000549573ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-
In-frameENST00000258530ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
In-frameENST00000539978ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
In-frameENST00000551662ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
intron-3CDSENST00000546731ENST00000378970APPL2chr12

105597481

-NR0B1chrX

30322940

-
intron-intronENST00000546731ENST00000378963APPL2chr12

105597481

-NR0B1chrX

30322940

-
intron-intronENST00000546731ENST00000453287APPL2chr12

105597481

-NR0B1chrX

30322940

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258530APPL2chr12105597481-ENST00000378970NR0B1chrX30322940-154893079999306
ENST00000539978APPL2chr12105597481-ENST00000378970NR0B1chrX30322940-162810102191079286
ENST00000551662APPL2chr12105597481-ENST00000378970NR0B1chrX30322940-141179323862279

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258530ENST00000378970APPL2chr12105597481-NR0B1chrX30322940-0.0004817710.9995183
ENST00000539978ENST00000378970APPL2chr12105597481-NR0B1chrX30322940-0.001172030.998828
ENST00000551662ENST00000378970APPL2chr12105597481-NR0B1chrX30322940-0.0007477380.99925226

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Fusion Genomic Features for APPL2-NR0B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APPL2-NR0B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:105597481/chrX:30322940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APPL2

Q8NEU8

.
FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNR0B1chr12:105597481chrX:30322940ENST0000045328702205_4690401.0DomainNR LBD
TgeneNR0B1chr12:105597481chrX:30322940ENST0000037897002461_466389471.0MotifNote=AF-2 motif
TgeneNR0B1chr12:105597481chrX:30322940ENST000004532870213_170401.0MotifNote=LXXLL motif 1
TgeneNR0B1chr12:105597481chrX:30322940ENST0000045328702146_1500401.0MotifNote=LXXLL motif 3
TgeneNR0B1chr12:105597481chrX:30322940ENST0000045328702461_4660401.0MotifNote=AF-2 motif
TgeneNR0B1chr12:105597481chrX:30322940ENST000004532870280_840401.0MotifNote=LXXLL motif 2
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287021_2530401.0RegionNote=4 X 67 AA tandem repeats
TgeneNR0B1chr12:105597481chrX:30322940ENST0000045328702134_2000401.0RepeatNote=3
TgeneNR0B1chr12:105597481chrX:30322940ENST00000453287021_670401.0RepeatNote=1
TgeneNR0B1chr12:105597481chrX:30322940ENST0000045328702201_2530401.0RepeatNote=4%3B truncated
TgeneNR0B1chr12:105597481chrX:30322940ENST000004532870268_1330401.0RepeatNote=2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPL2chr12:105597481chrX:30322940ENST00000258530-921277_375234665.0DomainPH
HgeneAPPL2chr12:105597481chrX:30322940ENST00000258530-9213_268234665.0DomainBAR
HgeneAPPL2chr12:105597481chrX:30322940ENST00000258530-921488_637234665.0DomainPID
HgeneAPPL2chr12:105597481chrX:30322940ENST00000539978-921277_375191622.0DomainPH
HgeneAPPL2chr12:105597481chrX:30322940ENST00000539978-9213_268191622.0DomainBAR
HgeneAPPL2chr12:105597481chrX:30322940ENST00000539978-921488_637191622.0DomainPID
HgeneAPPL2chr12:105597481chrX:30322940ENST00000551662-921277_375240671.0DomainPH
HgeneAPPL2chr12:105597481chrX:30322940ENST00000551662-9213_268240671.0DomainBAR
HgeneAPPL2chr12:105597481chrX:30322940ENST00000551662-921488_637240671.0DomainPID
HgeneAPPL2chr12:105597481chrX:30322940ENST00000258530-9211_428234665.0RegionRequired for RAB5A binding
HgeneAPPL2chr12:105597481chrX:30322940ENST00000539978-9211_428191622.0RegionRequired for RAB5A binding
HgeneAPPL2chr12:105597481chrX:30322940ENST00000551662-9211_428240671.0RegionRequired for RAB5A binding
TgeneNR0B1chr12:105597481chrX:30322940ENST0000037897002205_469389471.0DomainNR LBD
TgeneNR0B1chr12:105597481chrX:30322940ENST000003789700213_17389471.0MotifNote=LXXLL motif 1
TgeneNR0B1chr12:105597481chrX:30322940ENST0000037897002146_150389471.0MotifNote=LXXLL motif 3
TgeneNR0B1chr12:105597481chrX:30322940ENST000003789700280_84389471.0MotifNote=LXXLL motif 2
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970021_253389471.0RegionNote=4 X 67 AA tandem repeats
TgeneNR0B1chr12:105597481chrX:30322940ENST0000037897002134_200389471.0RepeatNote=3
TgeneNR0B1chr12:105597481chrX:30322940ENST00000378970021_67389471.0RepeatNote=1
TgeneNR0B1chr12:105597481chrX:30322940ENST0000037897002201_253389471.0RepeatNote=4%3B truncated
TgeneNR0B1chr12:105597481chrX:30322940ENST000003789700268_133389471.0RepeatNote=2


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Fusion Gene Sequence for APPL2-NR0B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5690_5690_1_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000258530_NR0B1_chrX_30322940_ENST00000378970_length(transcript)=1548nt_BP=930nt
TTTCCCTGCCGGGCGCGCCACACTTCCTGTTGATCCGGCTCGGCCGGGGGCTGGGCCGGCGGGCAGGCGGCGGCGGCCACTGGCCAGGCG
TGGACGCGCGCGGGGCCGCCGCGGGCACGGAGTGGCCGCCGCGTCGCCTGAGCCCAGAGCCGGGGAGTGCTCTCGGCCGCCGCGTCTCCT
GCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGA
CAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCA
GCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCT
TGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAA
ACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACT
CGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAA
AGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGC
CATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTT
TTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAA
TACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCA
ATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGA
TATAAAGTCATGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATGAGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTT
TAAAATAAACTTTCTTAATATTTTTACATGCAGAGTATTTTTGTATTCAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTC
TGTTCCATAGTTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTGTACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAG
CTATTTTCACAAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAATTTGTACATATTGTTATAATAAATTTTAAGGTCTTAACTATTAA

>5690_5690_1_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000258530_NR0B1_chrX_30322940_ENST00000378970_length(amino acids)=306AA_BP=283
MARRGRARGRRGHGVAAASPEPRAGECSRPPRLLPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLL
QAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKD
LFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKR

--------------------------------------------------------------
>5690_5690_2_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000539978_NR0B1_chrX_30322940_ENST00000378970_length(transcript)=1628nt_BP=1010nt
TCTATTCATGGACTCCTTTTTAGTTTGCAGTGCTGCACGATGCATTGTAAAACTAGTCTGTGTGCATACACATGCGTTATTTCTGCTTAC
CTCTCATATGTGGGAAGCTGAACATTTTAGGGATTAAGAAATCTGCCTCCATTGTTGTTTAGAAGCCTCTGCTCCTTGCCTGGCACTACT
GGCTGTTGGGAATGTGAAGATAAATAAGAGTGACTACCCTTGACTGGTTCACAGTTTGTTCCAGAGACAGATAATGAGGCAACAGTTCCA
GTACAGTGTGAATCCTGCTGCGATAGGAACACAAATGCAGCTTTGAGCTCCTGCAGCTTGTACTTCTTCAGGGGCTTATTCTCTTGTCCT
ACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTAT
GGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGT
GATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCA
GACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAAT
GAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCC
GCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAG
CCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCC
GTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAGTGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGA
ACACACCAGGATGACGCACCAAGGGCCCCATGACAGATTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGT
CATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACAGTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGATATAAAGTCA
TGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATGAGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTTTAAAATAAAC
TTTCTTAATATTTTTACATGCAGAGTATTTTTGTATTCAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTCTGTTCCATAG
TTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTGTACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAGCTATTTTCAC
AAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAATTTGTACATATTGTTATAATAAATTTTAAGGTCTTAACTATTAACTTGATTGAA

>5690_5690_2_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000539978_NR0B1_chrX_30322940_ENST00000378970_length(amino acids)=286AA_BP=263
MTGSQFVPETDNEATVPVQCESCCDRNTNAALSSCSLYFFRGLFSCPTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQL
SKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLP
KKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQRRAGPAV

--------------------------------------------------------------
>5690_5690_3_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000551662_NR0B1_chrX_30322940_ENST00000378970_length(transcript)=1411nt_BP=793nt
AGTGCTCTCGGCCGCCGCGTCTCCTGCCCTCTGTCCTTCCAACCCAGCCCTCGGCTGAGCCGCGCCGCACCATGCCCGCCGTGGACAAGC
TCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATA
CCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGG
CATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTA
ATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAA
GCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGATGTCTGTTTATTTTTAGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGC
CTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGT
ACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTT
TTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGACGTGCCGGGCCTGCAG
TGCGTGAAGTACATTCAGGGACTCCAGTGGGGAACTCAGCAAATACTCAGTGAACACACCAGGATGACGCACCAAGGGCCCCATGACAGA
TTCATCGAACTTAATAGTACCCTTTTCCTGCTGAGATTCATCAATGCCAATGTCATTGCTGAACTGTTCTTCAGGCCCATCATCGGCACA
GTCAGCATGGATGATATGATGCTGGAAATGCTCTGTACAAAGATATAAAGTCATGTGGGCCACACAAGTGCAGTAGTGCAGTTCACCATG
AGGGAAGAATAAAGAGCTGTGGGCAAAAGAGTGTAAAATATTTTAAAATAAACTTTCTTAATATTTTTACATGCAGAGTATTTTTGTATT
CAATTAAAGAAATAATTTTATTCCAGACAGTCACAAATTTCTCTGTTCCATAGTTAAAGAAGACATTTGCCAACAGGTAGCATAGCTCTG
TACATCTTTTAAAAAAAAAATAGCAGGGTACTAGTATAATAAGCTATTTTCACAAGTGTAGCAATTTCATGGAACCTGCTCAAATCAAAT

>5690_5690_3_APPL2-NR0B1_APPL2_chr12_105597481_ENST00000551662_NR0B1_chrX_30322940_ENST00000378970_length(amino acids)=279AA_BP=256
MPSVLPTQPSAEPRRTMPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFA
LGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNDVCLFLEHDLSMAKYSRLPKKKENEK
VKTEVGKEVAAARRKQHLSSLQYYCALNALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQRRAGPAVREVHSGT

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Fusion Gene PPI Analysis for APPL2-NR0B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APPL2-NR0B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APPL2-NR0B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource