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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:N4BP2L1-STX17 (FusionGDB2 ID:56906)

Fusion Gene Summary for N4BP2L1-STX17

check button Fusion gene summary
Fusion gene informationFusion gene name: N4BP2L1-STX17
Fusion gene ID: 56906
HgeneTgene
Gene symbol

N4BP2L1

STX17

Gene ID

90634

55014

Gene nameNEDD4 binding protein 2 like 1syntaxin 17
SynonymsCG018-
Cytomap

13q13.1

9q31.1

Type of geneprotein-codingprotein-coding
DescriptionNEDD4-binding protein 2-like 1hypothetical gene CG018syntaxin-17
Modification date2020031320200327
UniProtAcc

Q5TBK1

.
Ensembl transtripts involved in fusion geneENST00000380130, ENST00000380133, 
ENST00000380139, ENST00000530622, 
ENST00000459716, 		ENST00000525847, 
ENST00000259400, ENST00000525640, 
ENST00000534052, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 3 X 5=90
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: N4BP2L1 [Title/Abstract] AND STX17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointN4BP2L1(32981387)-STX17(102729935), # samples:1
Anticipated loss of major functional domain due to fusion event.N4BP2L1-STX17 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTX17

GO:0016240

autophagosome membrane docking

25686604

TgeneSTX17

GO:0034497

protein localization to phagophore assembly site

23455425

TgeneSTX17

GO:0097352

autophagosome maturation

28306502


check buttonFusion gene breakpoints across N4BP2L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STX17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0745-01AN4BP2L1chr13

32981387

-STX17chr9

102729935

+


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Fusion Gene ORF analysis for N4BP2L1-STX17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000380130ENST00000525847N4BP2L1chr13

32981387

-STX17chr9

102729935

+
5CDS-3UTRENST00000380133ENST00000525847N4BP2L1chr13

32981387

-STX17chr9

102729935

+
5CDS-3UTRENST00000380139ENST00000525847N4BP2L1chr13

32981387

-STX17chr9

102729935

+
5CDS-3UTRENST00000530622ENST00000525847N4BP2L1chr13

32981387

-STX17chr9

102729935

+
5UTR-3CDSENST00000459716ENST00000259400N4BP2L1chr13

32981387

-STX17chr9

102729935

+
5UTR-3CDSENST00000459716ENST00000525640N4BP2L1chr13

32981387

-STX17chr9

102729935

+
5UTR-3CDSENST00000459716ENST00000534052N4BP2L1chr13

32981387

-STX17chr9

102729935

+
5UTR-3UTRENST00000459716ENST00000525847N4BP2L1chr13

32981387

-STX17chr9

102729935

+
Frame-shiftENST00000380133ENST00000259400N4BP2L1chr13

32981387

-STX17chr9

102729935

+
Frame-shiftENST00000380133ENST00000525640N4BP2L1chr13

32981387

-STX17chr9

102729935

+
Frame-shiftENST00000380133ENST00000534052N4BP2L1chr13

32981387

-STX17chr9

102729935

+
Frame-shiftENST00000530622ENST00000259400N4BP2L1chr13

32981387

-STX17chr9

102729935

+
Frame-shiftENST00000530622ENST00000525640N4BP2L1chr13

32981387

-STX17chr9

102729935

+
Frame-shiftENST00000530622ENST00000534052N4BP2L1chr13

32981387

-STX17chr9

102729935

+
In-frameENST00000380130ENST00000259400N4BP2L1chr13

32981387

-STX17chr9

102729935

+
In-frameENST00000380130ENST00000525640N4BP2L1chr13

32981387

-STX17chr9

102729935

+
In-frameENST00000380130ENST00000534052N4BP2L1chr13

32981387

-STX17chr9

102729935

+
In-frameENST00000380139ENST00000259400N4BP2L1chr13

32981387

-STX17chr9

102729935

+
In-frameENST00000380139ENST00000525640N4BP2L1chr13

32981387

-STX17chr9

102729935

+
In-frameENST00000380139ENST00000534052N4BP2L1chr13

32981387

-STX17chr9

102729935

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380130N4BP2L1chr1332981387-ENST00000259400STX17chr9102729935+248249290818242
ENST00000380130N4BP2L1chr1332981387-ENST00000525640STX17chr9102729935+168649290818242
ENST00000380130N4BP2L1chr1332981387-ENST00000534052STX17chr9102729935+168649290818242
ENST00000380139N4BP2L1chr1332981387-ENST00000259400STX17chr9102729935+243744745773242
ENST00000380139N4BP2L1chr1332981387-ENST00000525640STX17chr9102729935+164144745773242
ENST00000380139N4BP2L1chr1332981387-ENST00000534052STX17chr9102729935+164144745773242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380130ENST00000259400N4BP2L1chr1332981387-STX17chr9102729935+0.004445070.995555
ENST00000380130ENST00000525640N4BP2L1chr1332981387-STX17chr9102729935+0.0061322280.9938678
ENST00000380130ENST00000534052N4BP2L1chr1332981387-STX17chr9102729935+0.0061322280.9938678
ENST00000380139ENST00000259400N4BP2L1chr1332981387-STX17chr9102729935+0.0038603640.9961396
ENST00000380139ENST00000525640N4BP2L1chr1332981387-STX17chr9102729935+0.0054129990.99458694
ENST00000380139ENST00000534052N4BP2L1chr1332981387-STX17chr9102729935+0.0054129990.99458694

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Fusion Genomic Features for N4BP2L1-STX17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
N4BP2L1chr1332981386-STX17chr9102729934+0.0016965370.9983034
N4BP2L1chr1332981386-STX17chr9102729934+0.0016965370.9983034

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for N4BP2L1-STX17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:32981387/chr9:102729935)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
N4BP2L1

Q5TBK1

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTX17chr13:32981387chr9:102729935ENST0000025940058299_302194303.0MotifEndoplasmic reticulum retention signal
TgeneSTX17chr13:32981387chr9:102729935ENST0000052564058299_302194303.0MotifEndoplasmic reticulum retention signal
TgeneSTX17chr13:32981387chr9:102729935ENST0000053405258299_302194303.0MotifEndoplasmic reticulum retention signal
TgeneSTX17chr13:32981387chr9:102729935ENST0000025940058229_275194303.0RegionNecessary and sufficient for localization to autophagosome
TgeneSTX17chr13:32981387chr9:102729935ENST0000052564058229_275194303.0RegionNecessary and sufficient for localization to autophagosome
TgeneSTX17chr13:32981387chr9:102729935ENST0000053405258229_275194303.0RegionNecessary and sufficient for localization to autophagosome
TgeneSTX17chr13:32981387chr9:102729935ENST0000025940058250_254194303.0Topological domainLumenal
TgeneSTX17chr13:32981387chr9:102729935ENST0000025940058276_302194303.0Topological domainCytoplasmic
TgeneSTX17chr13:32981387chr9:102729935ENST0000052564058250_254194303.0Topological domainLumenal
TgeneSTX17chr13:32981387chr9:102729935ENST0000052564058276_302194303.0Topological domainCytoplasmic
TgeneSTX17chr13:32981387chr9:102729935ENST0000053405258250_254194303.0Topological domainLumenal
TgeneSTX17chr13:32981387chr9:102729935ENST0000053405258276_302194303.0Topological domainCytoplasmic
TgeneSTX17chr13:32981387chr9:102729935ENST0000025940058229_249194303.0TransmembraneHelical
TgeneSTX17chr13:32981387chr9:102729935ENST0000025940058255_275194303.0TransmembraneHelical
TgeneSTX17chr13:32981387chr9:102729935ENST0000052564058229_249194303.0TransmembraneHelical
TgeneSTX17chr13:32981387chr9:102729935ENST0000052564058255_275194303.0TransmembraneHelical
TgeneSTX17chr13:32981387chr9:102729935ENST0000053405258229_249194303.0TransmembraneHelical
TgeneSTX17chr13:32981387chr9:102729935ENST0000053405258255_275194303.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTX17chr13:32981387chr9:102729935ENST000002594005853_123194303.0Coiled coilOntology_term=ECO:0000255
TgeneSTX17chr13:32981387chr9:102729935ENST000005256405853_123194303.0Coiled coilOntology_term=ECO:0000255
TgeneSTX17chr13:32981387chr9:102729935ENST000005340525853_123194303.0Coiled coilOntology_term=ECO:0000255
TgeneSTX17chr13:32981387chr9:102729935ENST0000025940058162_224194303.0Domaint-SNARE coiled-coil homology
TgeneSTX17chr13:32981387chr9:102729935ENST0000052564058162_224194303.0Domaint-SNARE coiled-coil homology
TgeneSTX17chr13:32981387chr9:102729935ENST0000053405258162_224194303.0Domaint-SNARE coiled-coil homology
TgeneSTX17chr13:32981387chr9:102729935ENST00000259400582_228194303.0Topological domainCytoplasmic
TgeneSTX17chr13:32981387chr9:102729935ENST00000525640582_228194303.0Topological domainCytoplasmic
TgeneSTX17chr13:32981387chr9:102729935ENST00000534052582_228194303.0Topological domainCytoplasmic


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Fusion Gene Sequence for N4BP2L1-STX17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56906_56906_1_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380130_STX17_chr9_102729935_ENST00000259400_length(transcript)=2482nt_BP=492nt
ATCACATGGCCGGAGAGTCACAAAAACAACAGCTTTGGCCAAGACCGTGACTTCAGTAAAGGGAACCCGGGGCTCTCGCAGCCAGCCCTC
CTGCCCATGGAGGACAGTTTCCTTCAATCTTTTGGGAGGCTGAGCCTCCAGCCCCAGCAGCAGCAGCAGCGGCAGCGGCCGCCCCGGCCG
CCCCCGCGGGGGACACCTCCTCGCCGCCACAGCTTTAGGAAACACCTCTACCTCCTGCGAGGCCTCCCGGGCTCCGGGAAAACTACACTG
GCCAGACAATTGCAGCATGACTTTCCCAGGGCCCTGATTTTCAGCACGGATGATTTTTTCTTCAGGGAAGATGGTGCCTATGAGTTCAAT
CCTGACTTCCTGGAGGAAGCTCATGAATGGAACCAAAAAAGAGCAAGAAAAGCAATGAGGAATGGCATATCCCCCATTATTATTGATAAT
ACCAACCTCCACGCCTGGGAAATGAAGCCCTATGCAGTCATGTCTCAGCAGGAGAAGATTGACAGCATTGCAGACCATGTCAACAGTGCT
GCTGTGAATGTTGAAGAGGGAACCAAAAACTTAGGGAAGGCTGCAAAATACAAGCTGGCAGCTCTGCCTGTGGCAGGTGCACTCATCGGG
GGAATGGTAGGGGGTCCTATTGGCCTCCTTGCAGGCTTCAAAGTGGCAGGAATTGCAGCTGCACTTGGTGGTGGGGTGTTGGGCTTCACA
GGTGGAAAATTGATACAAAGAAAGAAACAGAAAATGATGGAGAAGCTCACTTCCAGCTGTCCAGATCTTCCCAGCCAAACTGACAAGAAA
TGCAGTTAAAAACCAAATTTCAGTATTATTGGTGCCAACATGTCTATCCTGAGGACCTTTGCTGCTGTTGGACACTCCGTCACCTTTTGG
AACACAAGTATATCAAGATAGTGGCTACTGATGTTCAAGTGGGATTGAAGTGTGATAAATGGATATATTTTGTTGTTTGCTGGGGTGTTC
ATGGAGATGTTAAGAGATTGAGGCCCTGGGCTGAGGGTATATAATGTATGTCAGGTAAAGTTTGAAGACTGCCAAGGAGCAGATTTTCTC
CCTGGAAATGTGAAAACTGAACCTATAACTCTGATAAGGACTTGAGATGTGTAGAAACGTTGGGTTATGGAAGACTAGTTTCTTCCATAA
CCCTGAATTGGAGACCTTAATGCTAAGTGTAGATTATTGAGGTTTGTTAGTGAGGAAAAGAATAAGAGTTCAGAAGCCTTTGTTATCAGA
TAGCGAAATCAGGGCCTAGTGAGGAGCACAGGTCGACTACATAATGGAGTCCATTGGCGAACCCTATTGCAATTTGGTCCAACTATATCT
TCTGGTGAAGGAAATTAATGATGTAAGAAAATGCAAGAGGCTCAACTTCTCTTCCAAAAATCTTCTGGCTTCTGAACTCTTCCTCTGCCT
CTCTTTAAATAAATAACACAGAATTTCAAGTGGTAGGAGACTTATTAAGCCAGTCACCAAGCTTGGTCTGTCAGCCTGTCTTCTAACACC
TCAAAGATCTTGTGCCCTGTGCTGTCCCTCCCTTGTAATTATGAAAAGTTCTTTGGTTTCTGGGGTGAATTCTACCCATGTATAATGAGG
AATTCTCTCATAACCTTTTTTGTCTTGTCTGTCATCTCTGTTCATCCCTTCCTATAACCTCTAGGTAAAAAGAAAAGAAAAAAAGAAATT
TCGAGATATTTTCAACATTGTTAGAGTTTGGGCTAAAATGAGCAAGGAGAAAAAAACCACCAAGAACATTTCCTGGGGCATGTTCCAGTT
TTGAGGGGTGATATATCTGCCAGATAGGGGGTATCTGACCCAGTCTTCTTTTCAGCTGGTCTCTGGGGGGAGCTGAGAACTCGCTTGCTA
CCTCACATCCTTTTCCCCAGACTTTTTATCTCCTATGCATCCCTTTGCTTTCTATAGCTGGTGTTTCTTCCCCAAAATGGCGTTCCCATG
CTTACCTTTCTCACATTCTAGACAATGATGGACAAAGACGCATGCAAGACTCAGACCCGGGGAATGGTGTGGTGCTAATCTCAACACCTG
ACATTCACAGCAAGCATGGCCCAGCCCAACTGCATGTCTATCTCAAACCGCAGAAAGGCTTTAATACTGGAAAAAAAGAATTCAAGACTA
CAGGCAGCTCCCCTCTGTACCCCAACTCATTTAAAATAGGAGGAATCACTTTTTGCCTTACTTAACGCTTTTTTCTGAGCACAGGGATGG
GCACCTGCACCCCAGAAGGTGTGAGCTGTCTCTCTGCCAGGAGCTAAGGTTCATTAGGGGATTGGATGGTTTATCACTTCTTTCTTTCTG
AGTTTACTTTTAGTAACTTTTATTGATGGCTACCTTTCATGTCCCTGTCTAAAGAGACTTTCTCTTTCATACGTCTTAAATCTCATCAAT

>56906_56906_1_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380130_STX17_chr9_102729935_ENST00000259400_length(amino acids)=242AA_BP=134
MPMEDSFLQSFGRLSLQPQQQQQRQRPPRPPPRGTPPRRHSFRKHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDGAYEFN
PDFLEEAHEWNQKRARKAMRNGISPIIIDNTNLHAWEMKPYAVMSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIG

--------------------------------------------------------------
>56906_56906_2_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380130_STX17_chr9_102729935_ENST00000525640_length(transcript)=1686nt_BP=492nt
ATCACATGGCCGGAGAGTCACAAAAACAACAGCTTTGGCCAAGACCGTGACTTCAGTAAAGGGAACCCGGGGCTCTCGCAGCCAGCCCTC
CTGCCCATGGAGGACAGTTTCCTTCAATCTTTTGGGAGGCTGAGCCTCCAGCCCCAGCAGCAGCAGCAGCGGCAGCGGCCGCCCCGGCCG
CCCCCGCGGGGGACACCTCCTCGCCGCCACAGCTTTAGGAAACACCTCTACCTCCTGCGAGGCCTCCCGGGCTCCGGGAAAACTACACTG
GCCAGACAATTGCAGCATGACTTTCCCAGGGCCCTGATTTTCAGCACGGATGATTTTTTCTTCAGGGAAGATGGTGCCTATGAGTTCAAT
CCTGACTTCCTGGAGGAAGCTCATGAATGGAACCAAAAAAGAGCAAGAAAAGCAATGAGGAATGGCATATCCCCCATTATTATTGATAAT
ACCAACCTCCACGCCTGGGAAATGAAGCCCTATGCAGTCATGTCTCAGCAGGAGAAGATTGACAGCATTGCAGACCATGTCAACAGTGCT
GCTGTGAATGTTGAAGAGGGAACCAAAAACTTAGGGAAGGCTGCAAAATACAAGCTGGCAGCTCTGCCTGTGGCAGGTGCACTCATCGGG
GGAATGGTAGGGGGTCCTATTGGCCTCCTTGCAGGCTTCAAAGTGGCAGGAATTGCAGCTGCACTTGGTGGTGGGGTGTTGGGCTTCACA
GGTGGAAAATTGATACAAAGAAAGAAACAGAAAATGATGGAGAAGCTCACTTCCAGCTGTCCAGATCTTCCCAGCCAAACTGACAAGAAA
TGCAGTTAAAAACCAAATTTCAGTATTATTGGTGCCAACATGTCTATCCTGAGGACCTTTGCTGCTGTTGGACACTCCGTCACCTTTTGG
AACACAAGTATATCAAGATAGTGGCTACTGATGTTCAAGTGGGATTGAAGTGTGATAAATGGATATATTTTGTTGTTTGCTGGGGTGTTC
ATGGAGATGTTAAGAGATTGAGGCCCTGGGCTGAGGGTATATAATGTATGTCAGGTAAAGTTTGAAGACTGCCAAGGAGCAGATTTTCTC
CCTGGAAATGTGAAAACTGAACCTATAACTCTGATAAGGACTTGAGATGTGTAGAAACGTTGGGTTATGGAAGACTAGTTTCTTCCATAA
CCCTGAATTGGAGACCTTAATGCTAAGTGTAGATTATTGAGGTTTGTTAGTGAGGAAAAGAATAAGAGTTCAGAAGCCTTTGTTATCAGA
TAGCGAAATCAGGGCCTAGTGAGGAGCACAGGTCGACTACATAATGGAGTCCATTGGCGAACCCTATTGCAATTTGGTCCAACTATATCT
TCTGGTGAAGGAAATTAATGATGTAAGAAAATGCAAGAGGCTCAACTTCTCTTCCAAAAATCTTCTGGCTTCTGAACTCTTCCTCTGCCT
CTCTTTAAATAAATAACACAGAATTTCAAGTGGTAGGAGACTTATTAAGCCAGTCACCAAGCTTGGTCTGTCAGCCTGTCTTCTAACACC
TCAAAGATCTTGTGCCCTGTGCTGTCCCTCCCTTGTAATTATGAAAAGTTCTTTGGTTTCTGGGGTGAATTCTACCCATGTATAATGAGG

>56906_56906_2_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380130_STX17_chr9_102729935_ENST00000525640_length(amino acids)=242AA_BP=134
MPMEDSFLQSFGRLSLQPQQQQQRQRPPRPPPRGTPPRRHSFRKHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDGAYEFN
PDFLEEAHEWNQKRARKAMRNGISPIIIDNTNLHAWEMKPYAVMSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIG

--------------------------------------------------------------
>56906_56906_3_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380130_STX17_chr9_102729935_ENST00000534052_length(transcript)=1686nt_BP=492nt
ATCACATGGCCGGAGAGTCACAAAAACAACAGCTTTGGCCAAGACCGTGACTTCAGTAAAGGGAACCCGGGGCTCTCGCAGCCAGCCCTC
CTGCCCATGGAGGACAGTTTCCTTCAATCTTTTGGGAGGCTGAGCCTCCAGCCCCAGCAGCAGCAGCAGCGGCAGCGGCCGCCCCGGCCG
CCCCCGCGGGGGACACCTCCTCGCCGCCACAGCTTTAGGAAACACCTCTACCTCCTGCGAGGCCTCCCGGGCTCCGGGAAAACTACACTG
GCCAGACAATTGCAGCATGACTTTCCCAGGGCCCTGATTTTCAGCACGGATGATTTTTTCTTCAGGGAAGATGGTGCCTATGAGTTCAAT
CCTGACTTCCTGGAGGAAGCTCATGAATGGAACCAAAAAAGAGCAAGAAAAGCAATGAGGAATGGCATATCCCCCATTATTATTGATAAT
ACCAACCTCCACGCCTGGGAAATGAAGCCCTATGCAGTCATGTCTCAGCAGGAGAAGATTGACAGCATTGCAGACCATGTCAACAGTGCT
GCTGTGAATGTTGAAGAGGGAACCAAAAACTTAGGGAAGGCTGCAAAATACAAGCTGGCAGCTCTGCCTGTGGCAGGTGCACTCATCGGG
GGAATGGTAGGGGGTCCTATTGGCCTCCTTGCAGGCTTCAAAGTGGCAGGAATTGCAGCTGCACTTGGTGGTGGGGTGTTGGGCTTCACA
GGTGGAAAATTGATACAAAGAAAGAAACAGAAAATGATGGAGAAGCTCACTTCCAGCTGTCCAGATCTTCCCAGCCAAACTGACAAGAAA
TGCAGTTAAAAACCAAATTTCAGTATTATTGGTGCCAACATGTCTATCCTGAGGACCTTTGCTGCTGTTGGACACTCCGTCACCTTTTGG
AACACAAGTATATCAAGATAGTGGCTACTGATGTTCAAGTGGGATTGAAGTGTGATAAATGGATATATTTTGTTGTTTGCTGGGGTGTTC
ATGGAGATGTTAAGAGATTGAGGCCCTGGGCTGAGGGTATATAATGTATGTCAGGTAAAGTTTGAAGACTGCCAAGGAGCAGATTTTCTC
CCTGGAAATGTGAAAACTGAACCTATAACTCTGATAAGGACTTGAGATGTGTAGAAACGTTGGGTTATGGAAGACTAGTTTCTTCCATAA
CCCTGAATTGGAGACCTTAATGCTAAGTGTAGATTATTGAGGTTTGTTAGTGAGGAAAAGAATAAGAGTTCAGAAGCCTTTGTTATCAGA
TAGCGAAATCAGGGCCTAGTGAGGAGCACAGGTCGACTACATAATGGAGTCCATTGGCGAACCCTATTGCAATTTGGTCCAACTATATCT
TCTGGTGAAGGAAATTAATGATGTAAGAAAATGCAAGAGGCTCAACTTCTCTTCCAAAAATCTTCTGGCTTCTGAACTCTTCCTCTGCCT
CTCTTTAAATAAATAACACAGAATTTCAAGTGGTAGGAGACTTATTAAGCCAGTCACCAAGCTTGGTCTGTCAGCCTGTCTTCTAACACC
TCAAAGATCTTGTGCCCTGTGCTGTCCCTCCCTTGTAATTATGAAAAGTTCTTTGGTTTCTGGGGTGAATTCTACCCATGTATAATGAGG

>56906_56906_3_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380130_STX17_chr9_102729935_ENST00000534052_length(amino acids)=242AA_BP=134
MPMEDSFLQSFGRLSLQPQQQQQRQRPPRPPPRGTPPRRHSFRKHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDGAYEFN
PDFLEEAHEWNQKRARKAMRNGISPIIIDNTNLHAWEMKPYAVMSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIG

--------------------------------------------------------------
>56906_56906_4_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380139_STX17_chr9_102729935_ENST00000259400_length(transcript)=2437nt_BP=447nt
CGTGACTTCAGTAAAGGGAACCCGGGGCTCTCGCAGCCAGCCCTCCTGCCCATGGAGGACAGTTTCCTTCAATCTTTTGGGAGGCTGAGC
CTCCAGCCCCAGCAGCAGCAGCAGCGGCAGCGGCCGCCCCGGCCGCCCCCGCGGGGGACACCTCCTCGCCGCCACAGCTTTAGGAAACAC
CTCTACCTCCTGCGAGGCCTCCCGGGCTCCGGGAAAACTACACTGGCCAGACAATTGCAGCATGACTTTCCCAGGGCCCTGATTTTCAGC
ACGGATGATTTTTTCTTCAGGGAAGATGGTGCCTATGAGTTCAATCCTGACTTCCTGGAGGAAGCTCATGAATGGAACCAAAAAAGAGCA
AGAAAAGCAATGAGGAATGGCATATCCCCCATTATTATTGATAATACCAACCTCCACGCCTGGGAAATGAAGCCCTATGCAGTCATGTCT
CAGCAGGAGAAGATTGACAGCATTGCAGACCATGTCAACAGTGCTGCTGTGAATGTTGAAGAGGGAACCAAAAACTTAGGGAAGGCTGCA
AAATACAAGCTGGCAGCTCTGCCTGTGGCAGGTGCACTCATCGGGGGAATGGTAGGGGGTCCTATTGGCCTCCTTGCAGGCTTCAAAGTG
GCAGGAATTGCAGCTGCACTTGGTGGTGGGGTGTTGGGCTTCACAGGTGGAAAATTGATACAAAGAAAGAAACAGAAAATGATGGAGAAG
CTCACTTCCAGCTGTCCAGATCTTCCCAGCCAAACTGACAAGAAATGCAGTTAAAAACCAAATTTCAGTATTATTGGTGCCAACATGTCT
ATCCTGAGGACCTTTGCTGCTGTTGGACACTCCGTCACCTTTTGGAACACAAGTATATCAAGATAGTGGCTACTGATGTTCAAGTGGGAT
TGAAGTGTGATAAATGGATATATTTTGTTGTTTGCTGGGGTGTTCATGGAGATGTTAAGAGATTGAGGCCCTGGGCTGAGGGTATATAAT
GTATGTCAGGTAAAGTTTGAAGACTGCCAAGGAGCAGATTTTCTCCCTGGAAATGTGAAAACTGAACCTATAACTCTGATAAGGACTTGA
GATGTGTAGAAACGTTGGGTTATGGAAGACTAGTTTCTTCCATAACCCTGAATTGGAGACCTTAATGCTAAGTGTAGATTATTGAGGTTT
GTTAGTGAGGAAAAGAATAAGAGTTCAGAAGCCTTTGTTATCAGATAGCGAAATCAGGGCCTAGTGAGGAGCACAGGTCGACTACATAAT
GGAGTCCATTGGCGAACCCTATTGCAATTTGGTCCAACTATATCTTCTGGTGAAGGAAATTAATGATGTAAGAAAATGCAAGAGGCTCAA
CTTCTCTTCCAAAAATCTTCTGGCTTCTGAACTCTTCCTCTGCCTCTCTTTAAATAAATAACACAGAATTTCAAGTGGTAGGAGACTTAT
TAAGCCAGTCACCAAGCTTGGTCTGTCAGCCTGTCTTCTAACACCTCAAAGATCTTGTGCCCTGTGCTGTCCCTCCCTTGTAATTATGAA
AAGTTCTTTGGTTTCTGGGGTGAATTCTACCCATGTATAATGAGGAATTCTCTCATAACCTTTTTTGTCTTGTCTGTCATCTCTGTTCAT
CCCTTCCTATAACCTCTAGGTAAAAAGAAAAGAAAAAAAGAAATTTCGAGATATTTTCAACATTGTTAGAGTTTGGGCTAAAATGAGCAA
GGAGAAAAAAACCACCAAGAACATTTCCTGGGGCATGTTCCAGTTTTGAGGGGTGATATATCTGCCAGATAGGGGGTATCTGACCCAGTC
TTCTTTTCAGCTGGTCTCTGGGGGGAGCTGAGAACTCGCTTGCTACCTCACATCCTTTTCCCCAGACTTTTTATCTCCTATGCATCCCTT
TGCTTTCTATAGCTGGTGTTTCTTCCCCAAAATGGCGTTCCCATGCTTACCTTTCTCACATTCTAGACAATGATGGACAAAGACGCATGC
AAGACTCAGACCCGGGGAATGGTGTGGTGCTAATCTCAACACCTGACATTCACAGCAAGCATGGCCCAGCCCAACTGCATGTCTATCTCA
AACCGCAGAAAGGCTTTAATACTGGAAAAAAAGAATTCAAGACTACAGGCAGCTCCCCTCTGTACCCCAACTCATTTAAAATAGGAGGAA
TCACTTTTTGCCTTACTTAACGCTTTTTTCTGAGCACAGGGATGGGCACCTGCACCCCAGAAGGTGTGAGCTGTCTCTCTGCCAGGAGCT
AAGGTTCATTAGGGGATTGGATGGTTTATCACTTCTTTCTTTCTGAGTTTACTTTTAGTAACTTTTATTGATGGCTACCTTTCATGTCCC
TGTCTAAAGAGACTTTCTCTTTCATACGTCTTAAATCTCATCAATGAAATCCAGTGAAACAGCACCATTTCTTAGTATCATTAAATAACT

>56906_56906_4_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380139_STX17_chr9_102729935_ENST00000259400_length(amino acids)=242AA_BP=134
MPMEDSFLQSFGRLSLQPQQQQQRQRPPRPPPRGTPPRRHSFRKHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDGAYEFN
PDFLEEAHEWNQKRARKAMRNGISPIIIDNTNLHAWEMKPYAVMSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIG

--------------------------------------------------------------
>56906_56906_5_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380139_STX17_chr9_102729935_ENST00000525640_length(transcript)=1641nt_BP=447nt
CGTGACTTCAGTAAAGGGAACCCGGGGCTCTCGCAGCCAGCCCTCCTGCCCATGGAGGACAGTTTCCTTCAATCTTTTGGGAGGCTGAGC
CTCCAGCCCCAGCAGCAGCAGCAGCGGCAGCGGCCGCCCCGGCCGCCCCCGCGGGGGACACCTCCTCGCCGCCACAGCTTTAGGAAACAC
CTCTACCTCCTGCGAGGCCTCCCGGGCTCCGGGAAAACTACACTGGCCAGACAATTGCAGCATGACTTTCCCAGGGCCCTGATTTTCAGC
ACGGATGATTTTTTCTTCAGGGAAGATGGTGCCTATGAGTTCAATCCTGACTTCCTGGAGGAAGCTCATGAATGGAACCAAAAAAGAGCA
AGAAAAGCAATGAGGAATGGCATATCCCCCATTATTATTGATAATACCAACCTCCACGCCTGGGAAATGAAGCCCTATGCAGTCATGTCT
CAGCAGGAGAAGATTGACAGCATTGCAGACCATGTCAACAGTGCTGCTGTGAATGTTGAAGAGGGAACCAAAAACTTAGGGAAGGCTGCA
AAATACAAGCTGGCAGCTCTGCCTGTGGCAGGTGCACTCATCGGGGGAATGGTAGGGGGTCCTATTGGCCTCCTTGCAGGCTTCAAAGTG
GCAGGAATTGCAGCTGCACTTGGTGGTGGGGTGTTGGGCTTCACAGGTGGAAAATTGATACAAAGAAAGAAACAGAAAATGATGGAGAAG
CTCACTTCCAGCTGTCCAGATCTTCCCAGCCAAACTGACAAGAAATGCAGTTAAAAACCAAATTTCAGTATTATTGGTGCCAACATGTCT
ATCCTGAGGACCTTTGCTGCTGTTGGACACTCCGTCACCTTTTGGAACACAAGTATATCAAGATAGTGGCTACTGATGTTCAAGTGGGAT
TGAAGTGTGATAAATGGATATATTTTGTTGTTTGCTGGGGTGTTCATGGAGATGTTAAGAGATTGAGGCCCTGGGCTGAGGGTATATAAT
GTATGTCAGGTAAAGTTTGAAGACTGCCAAGGAGCAGATTTTCTCCCTGGAAATGTGAAAACTGAACCTATAACTCTGATAAGGACTTGA
GATGTGTAGAAACGTTGGGTTATGGAAGACTAGTTTCTTCCATAACCCTGAATTGGAGACCTTAATGCTAAGTGTAGATTATTGAGGTTT
GTTAGTGAGGAAAAGAATAAGAGTTCAGAAGCCTTTGTTATCAGATAGCGAAATCAGGGCCTAGTGAGGAGCACAGGTCGACTACATAAT
GGAGTCCATTGGCGAACCCTATTGCAATTTGGTCCAACTATATCTTCTGGTGAAGGAAATTAATGATGTAAGAAAATGCAAGAGGCTCAA
CTTCTCTTCCAAAAATCTTCTGGCTTCTGAACTCTTCCTCTGCCTCTCTTTAAATAAATAACACAGAATTTCAAGTGGTAGGAGACTTAT
TAAGCCAGTCACCAAGCTTGGTCTGTCAGCCTGTCTTCTAACACCTCAAAGATCTTGTGCCCTGTGCTGTCCCTCCCTTGTAATTATGAA
AAGTTCTTTGGTTTCTGGGGTGAATTCTACCCATGTATAATGAGGAATTCTCTCATAACCTTTTTTGTCTTGTCTGTCATCTCTGTTCAT

>56906_56906_5_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380139_STX17_chr9_102729935_ENST00000525640_length(amino acids)=242AA_BP=134
MPMEDSFLQSFGRLSLQPQQQQQRQRPPRPPPRGTPPRRHSFRKHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDGAYEFN
PDFLEEAHEWNQKRARKAMRNGISPIIIDNTNLHAWEMKPYAVMSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIG

--------------------------------------------------------------
>56906_56906_6_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380139_STX17_chr9_102729935_ENST00000534052_length(transcript)=1641nt_BP=447nt
CGTGACTTCAGTAAAGGGAACCCGGGGCTCTCGCAGCCAGCCCTCCTGCCCATGGAGGACAGTTTCCTTCAATCTTTTGGGAGGCTGAGC
CTCCAGCCCCAGCAGCAGCAGCAGCGGCAGCGGCCGCCCCGGCCGCCCCCGCGGGGGACACCTCCTCGCCGCCACAGCTTTAGGAAACAC
CTCTACCTCCTGCGAGGCCTCCCGGGCTCCGGGAAAACTACACTGGCCAGACAATTGCAGCATGACTTTCCCAGGGCCCTGATTTTCAGC
ACGGATGATTTTTTCTTCAGGGAAGATGGTGCCTATGAGTTCAATCCTGACTTCCTGGAGGAAGCTCATGAATGGAACCAAAAAAGAGCA
AGAAAAGCAATGAGGAATGGCATATCCCCCATTATTATTGATAATACCAACCTCCACGCCTGGGAAATGAAGCCCTATGCAGTCATGTCT
CAGCAGGAGAAGATTGACAGCATTGCAGACCATGTCAACAGTGCTGCTGTGAATGTTGAAGAGGGAACCAAAAACTTAGGGAAGGCTGCA
AAATACAAGCTGGCAGCTCTGCCTGTGGCAGGTGCACTCATCGGGGGAATGGTAGGGGGTCCTATTGGCCTCCTTGCAGGCTTCAAAGTG
GCAGGAATTGCAGCTGCACTTGGTGGTGGGGTGTTGGGCTTCACAGGTGGAAAATTGATACAAAGAAAGAAACAGAAAATGATGGAGAAG
CTCACTTCCAGCTGTCCAGATCTTCCCAGCCAAACTGACAAGAAATGCAGTTAAAAACCAAATTTCAGTATTATTGGTGCCAACATGTCT
ATCCTGAGGACCTTTGCTGCTGTTGGACACTCCGTCACCTTTTGGAACACAAGTATATCAAGATAGTGGCTACTGATGTTCAAGTGGGAT
TGAAGTGTGATAAATGGATATATTTTGTTGTTTGCTGGGGTGTTCATGGAGATGTTAAGAGATTGAGGCCCTGGGCTGAGGGTATATAAT
GTATGTCAGGTAAAGTTTGAAGACTGCCAAGGAGCAGATTTTCTCCCTGGAAATGTGAAAACTGAACCTATAACTCTGATAAGGACTTGA
GATGTGTAGAAACGTTGGGTTATGGAAGACTAGTTTCTTCCATAACCCTGAATTGGAGACCTTAATGCTAAGTGTAGATTATTGAGGTTT
GTTAGTGAGGAAAAGAATAAGAGTTCAGAAGCCTTTGTTATCAGATAGCGAAATCAGGGCCTAGTGAGGAGCACAGGTCGACTACATAAT
GGAGTCCATTGGCGAACCCTATTGCAATTTGGTCCAACTATATCTTCTGGTGAAGGAAATTAATGATGTAAGAAAATGCAAGAGGCTCAA
CTTCTCTTCCAAAAATCTTCTGGCTTCTGAACTCTTCCTCTGCCTCTCTTTAAATAAATAACACAGAATTTCAAGTGGTAGGAGACTTAT
TAAGCCAGTCACCAAGCTTGGTCTGTCAGCCTGTCTTCTAACACCTCAAAGATCTTGTGCCCTGTGCTGTCCCTCCCTTGTAATTATGAA
AAGTTCTTTGGTTTCTGGGGTGAATTCTACCCATGTATAATGAGGAATTCTCTCATAACCTTTTTTGTCTTGTCTGTCATCTCTGTTCAT

>56906_56906_6_N4BP2L1-STX17_N4BP2L1_chr13_32981387_ENST00000380139_STX17_chr9_102729935_ENST00000534052_length(amino acids)=242AA_BP=134
MPMEDSFLQSFGRLSLQPQQQQQRQRPPRPPPRGTPPRRHSFRKHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDGAYEFN
PDFLEEAHEWNQKRARKAMRNGISPIIIDNTNLHAWEMKPYAVMSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYKLAALPVAGALIG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for N4BP2L1-STX17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for N4BP2L1-STX17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for N4BP2L1-STX17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource