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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NAA10-HCFC1 (FusionGDB2 ID:56931) |
Fusion Gene Summary for NAA10-HCFC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NAA10-HCFC1 | Fusion gene ID: 56931 | Hgene | Tgene | Gene symbol | NAA10 | HCFC1 | Gene ID | 8260 | 3054 |
| Gene name | N-alpha-acetyltransferase 10, NatA catalytic subunit | host cell factor C1 | |
| Synonyms | ARD1|ARD1A|ARD1P|DXS707|MCOPS1|NATD|OGDNS|TE2|hARD1 | CFF|HCF|HCF-1|HCF1|HFC1|MRX3|PPP1R89|VCAF | |
| Cytomap | Xq28 | Xq28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-alpha-acetyltransferase 10ARD1 homolog A, N-acetyltransferaseN-acetyltransferase ARD1, human homolog ofN-terminal acetyltransferase complex ARD1 subunit homolog Aarrest defective protein 1natA catalytic subunit Naa10 | host cell factor 1VP16-accessory proteinprotein phosphatase 1, regulatory subunit 89 | |
| Modification date | 20200328 | 20200313 | |
| UniProtAcc | P41227 | Q9NWW0 | |
| Ensembl transtripts involved in fusion gene | ENST00000370009, ENST00000370015, ENST00000393712, ENST00000464845, ENST00000393710, | ENST00000461098, ENST00000310441, ENST00000354233, ENST00000369984, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 6 X 7 X 3=126 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NAA10 [Title/Abstract] AND HCFC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NAA10(153196216)-HCFC1(153218409), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NAA10 | GO:0006473 | protein acetylation | 27708256 |
| Hgene | NAA10 | GO:0006474 | N-terminal protein amino acid acetylation | 15496142|19480662|25489052 |
| Hgene | NAA10 | GO:2000719 | negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric | 27422821 |
| Tgene | HCFC1 | GO:0006355 | regulation of transcription, DNA-templated | 12670868 |
| Tgene | HCFC1 | GO:0010628 | positive regulation of gene expression | 21285374 |
| Tgene | HCFC1 | GO:0043254 | regulation of protein complex assembly | 10675337 |
| Tgene | HCFC1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Tgene | HCFC1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Tgene | HCFC1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Tgene | HCFC1 | GO:0050821 | protein stabilization | 21285374 |
| Fusion gene breakpoints across NAA10 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HCFC1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-62-A46O-01A | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
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Fusion Gene ORF analysis for NAA10-HCFC1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000370009 | ENST00000461098 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| 5CDS-intron | ENST00000370015 | ENST00000461098 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| 5CDS-intron | ENST00000393712 | ENST00000461098 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| 5CDS-intron | ENST00000464845 | ENST00000461098 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000370009 | ENST00000310441 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000370009 | ENST00000354233 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000370009 | ENST00000369984 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000370015 | ENST00000310441 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000370015 | ENST00000354233 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000370015 | ENST00000369984 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000393712 | ENST00000310441 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000393712 | ENST00000354233 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000393712 | ENST00000369984 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000464845 | ENST00000310441 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000464845 | ENST00000354233 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| In-frame | ENST00000464845 | ENST00000369984 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| intron-3CDS | ENST00000393710 | ENST00000310441 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| intron-3CDS | ENST00000393710 | ENST00000354233 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| intron-3CDS | ENST00000393710 | ENST00000369984 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| intron-intron | ENST00000393710 | ENST00000461098 | NAA10 | chrX | 153196216 | - | HCFC1 | chrX | 153218409 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for NAA10-HCFC1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NAA10-HCFC1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153196216/chrX:153218409) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NAA10 | HCFC1 |
| FUNCTION: Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052, PubMed:29754825). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825}. | FUNCTION: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. {ECO:0000269|PubMed:12235138}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NAA10 | chrX:153196216 | chrX:153218409 | ENST00000464845 | - | 7 | 8 | 1_152 | 157 | 236.0 | Domain | N-acetyltransferase |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1797_1888 | 1499 | 2036.0 | Domain | Fibronectin type-III 2 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1890_2006 | 1499 | 2036.0 | Domain | Fibronectin type-III 3 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1797_1888 | 1430 | 1967.0 | Domain | Fibronectin type-III 2 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1890_2006 | 1430 | 1967.0 | Domain | Fibronectin type-III 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NAA10 | chrX:153196216 | chrX:153218409 | ENST00000370009 | - | 6 | 7 | 1_152 | 142 | 221.0 | Domain | N-acetyltransferase |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 366_466 | 1499 | 2036.0 | Domain | Fibronectin type-III 1 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 366_466 | 1430 | 1967.0 | Domain | Fibronectin type-III 1 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1010_1035 | 1499 | 2036.0 | Repeat | Note=HCF repeat 1 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1072_1097 | 1499 | 2036.0 | Repeat | Note=HCF repeat 2 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1101_1126 | 1499 | 2036.0 | Repeat | Note=HCF repeat 3 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1158_1183 | 1499 | 2036.0 | Repeat | Note=HCF repeat 4%3B degenerate | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1286_1311 | 1499 | 2036.0 | Repeat | Note=HCF repeat 5 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1314_1339 | 1499 | 2036.0 | Repeat | Note=HCF repeat 6 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1349_1374 | 1499 | 2036.0 | Repeat | Note=HCF repeat 7%3B degenerate | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 1414_1439 | 1499 | 2036.0 | Repeat | Note=HCF repeat 8 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 148_194 | 1499 | 2036.0 | Repeat | Note=Kelch 3 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 217_265 | 1499 | 2036.0 | Repeat | Note=Kelch 4 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 266_313 | 1499 | 2036.0 | Repeat | Note=Kelch 5 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 44_89 | 1499 | 2036.0 | Repeat | Note=Kelch 1 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 93_140 | 1499 | 2036.0 | Repeat | Note=Kelch 2 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1010_1035 | 1430 | 1967.0 | Repeat | Note=HCF repeat 1 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1072_1097 | 1430 | 1967.0 | Repeat | Note=HCF repeat 2 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1101_1126 | 1430 | 1967.0 | Repeat | Note=HCF repeat 3 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1158_1183 | 1430 | 1967.0 | Repeat | Note=HCF repeat 4%3B degenerate | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1286_1311 | 1430 | 1967.0 | Repeat | Note=HCF repeat 5 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1314_1339 | 1430 | 1967.0 | Repeat | Note=HCF repeat 6 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1349_1374 | 1430 | 1967.0 | Repeat | Note=HCF repeat 7%3B degenerate | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 1414_1439 | 1430 | 1967.0 | Repeat | Note=HCF repeat 8 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 148_194 | 1430 | 1967.0 | Repeat | Note=Kelch 3 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 217_265 | 1430 | 1967.0 | Repeat | Note=Kelch 4 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 266_313 | 1430 | 1967.0 | Repeat | Note=Kelch 5 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 44_89 | 1430 | 1967.0 | Repeat | Note=Kelch 1 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 93_140 | 1430 | 1967.0 | Repeat | Note=Kelch 2 |
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Fusion Gene Sequence for NAA10-HCFC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for NAA10-HCFC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | NAA10 | chrX:153196216 | chrX:153218409 | ENST00000370009 | - | 6 | 7 | 1_58 | 142.0 | 221.0 | NAA15 |
| Hgene | NAA10 | chrX:153196216 | chrX:153218409 | ENST00000464845 | - | 7 | 8 | 1_58 | 157.0 | 236.0 | NAA15 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 813_912 | 1499.0 | 2036.0 | GABP2 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 813_912 | 1430.0 | 1967.0 | GABP2 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 610_722 | 1499.0 | 2036.0 | SIN3A | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 610_722 | 1430.0 | 1967.0 | SIN3A | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000310441 | 17 | 26 | 750_902 | 1499.0 | 2036.0 | ZBTB17 | |
| Tgene | HCFC1 | chrX:153196216 | chrX:153218409 | ENST00000354233 | 18 | 27 | 750_902 | 1430.0 | 1967.0 | ZBTB17 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NAA10-HCFC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NAA10-HCFC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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