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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAA20-ATP8B4 (FusionGDB2 ID:56958)

Fusion Gene Summary for NAA20-ATP8B4

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA20-ATP8B4
Fusion gene ID: 56958
HgeneTgene
Gene symbol

NAA20

ATP8B4

Gene ID

51126

79895

Gene nameN-alpha-acetyltransferase 20, NatB catalytic subunitATPase phospholipid transporting 8B4 (putative)
SynonymsNAT3|NAT3P|NAT5|NAT5P|dJ1002M8.1ATPIM
Cytomap

20p11.23

15q21.2

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 20N-acetyltransferase 3 homologN-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)N-acetyltransferase 5 (GCN5-related, putative)N-acetyltransferase 5, ARD1 subunit (arrest-defective 1, S. cerevisiae, homolog)N-terminal acetyprobable phospholipid-transporting ATPase IMATPase, class I, type 8B, member 4P4-ATPase flippase complex alpha subunit ATP8B4potential phospholipid-transporting ATPase IM
Modification date2020032020200313
UniProtAcc

P61599

Q8TF62

Ensembl transtripts involved in fusion geneENST00000484480, ENST00000334982, 
ENST00000398602, ENST00000310450, 
ENST00000284509, ENST00000559829, 
ENST00000558959, 
Fusion gene scores* DoF score8 X 7 X 3=16810 X 10 X 6=600
# samples 811
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAA20 [Title/Abstract] AND ATP8B4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAA20(20013297)-ATP8B4(50273491), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NAA20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP8B4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A27B-01ANAA20chr20

20013297

+ATP8B4chr15

50273491

-


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Fusion Gene ORF analysis for NAA20-ATP8B4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000484480ENST00000284509NAA20chr20

20013297

+ATP8B4chr15

50273491

-
3UTR-3CDSENST00000484480ENST00000559829NAA20chr20

20013297

+ATP8B4chr15

50273491

-
3UTR-5UTRENST00000484480ENST00000558959NAA20chr20

20013297

+ATP8B4chr15

50273491

-
5CDS-5UTRENST00000334982ENST00000558959NAA20chr20

20013297

+ATP8B4chr15

50273491

-
5CDS-5UTRENST00000398602ENST00000558959NAA20chr20

20013297

+ATP8B4chr15

50273491

-
In-frameENST00000334982ENST00000284509NAA20chr20

20013297

+ATP8B4chr15

50273491

-
In-frameENST00000334982ENST00000559829NAA20chr20

20013297

+ATP8B4chr15

50273491

-
In-frameENST00000398602ENST00000284509NAA20chr20

20013297

+ATP8B4chr15

50273491

-
In-frameENST00000398602ENST00000559829NAA20chr20

20013297

+ATP8B4chr15

50273491

-
intron-3CDSENST00000310450ENST00000284509NAA20chr20

20013297

+ATP8B4chr15

50273491

-
intron-3CDSENST00000310450ENST00000559829NAA20chr20

20013297

+ATP8B4chr15

50273491

-
intron-5UTRENST00000310450ENST00000558959NAA20chr20

20013297

+ATP8B4chr15

50273491

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334982NAA20chr2020013297+ENST00000284509ATP8B4chr1550273491-55197322935621177
ENST00000334982NAA20chr2020013297+ENST00000559829ATP8B4chr1550273491-47577322935621177
ENST00000398602NAA20chr2020013297+ENST00000284509ATP8B4chr1550273491-5837105061738801087
ENST00000398602NAA20chr2020013297+ENST00000559829ATP8B4chr1550273491-5075105061738801087

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334982ENST00000284509NAA20chr2020013297+ATP8B4chr1550273491-0.0001033540.99989665
ENST00000334982ENST00000559829NAA20chr2020013297+ATP8B4chr1550273491-0.0001751430.99982494
ENST00000398602ENST00000284509NAA20chr2020013297+ATP8B4chr1550273491-0.0001521440.9998479
ENST00000398602ENST00000559829NAA20chr2020013297+ATP8B4chr1550273491-0.000246620.9997534

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Fusion Genomic Features for NAA20-ATP8B4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAA20-ATP8B4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:20013297/chr15:50273491)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA20

P61599

ATP8B4

Q8TF62

FUNCTION: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. {ECO:0000269|PubMed:18570629}.FUNCTION: Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP8B4chr20:20013297chr15:50273491ENST000002845099281014_10192491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST000002845099281041_10602491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST000002845099281086_11922491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928299_3272491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928350_8712491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928893_9042491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928925_9542491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928977_9902491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST000005598299281014_10192491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST000005598299281041_10602491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST000005598299281086_11922491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928299_3272491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928350_8712491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928893_9042491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928925_9542491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928977_9902491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST000002845099281020_10402491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST000002845099281061_10852491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928277_2982491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928328_3492491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928872_8922491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928905_9242491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928955_9762491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000284509928991_10132491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST000005598299281020_10402491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST000005598299281061_10852491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928277_2982491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928328_3492491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928872_8922491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928905_9242491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928955_9762491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST00000559829928991_10132491193.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAA20chr20:20013297chr15:50273491ENST00000310450+152_1570112.0DomainN-acetyltransferase
HgeneNAA20chr20:20013297chr15:50273491ENST00000334982+562_157150179.0DomainN-acetyltransferase
TgeneATP8B4chr20:20013297chr15:50273491ENST000002845099281_442491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST0000028450992867_722491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST0000028450992893_2762491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST000005598299281_442491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST0000055982992867_722491193.0Topological domainExoplasmic loop
TgeneATP8B4chr20:20013297chr15:50273491ENST0000055982992893_2762491193.0Topological domainCytoplasmic
TgeneATP8B4chr20:20013297chr15:50273491ENST0000028450992845_662491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST0000028450992873_922491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST0000055982992845_662491193.0TransmembraneHelical
TgeneATP8B4chr20:20013297chr15:50273491ENST0000055982992873_922491193.0TransmembraneHelical


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Fusion Gene Sequence for NAA20-ATP8B4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56958_56958_1_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000334982_ATP8B4_chr15_50273491_ENST00000284509_length(transcript)=5519nt_BP=732nt
TTTCCTTCCCAGGTGTCGCCGCCTGCTTTCTGCAGCCGCTGCCTGGGAGGGGTTCCGAGGTTCTGGGCAGCCACAGCCCCGGAGGCCTTA
CAGGAGCGACCTGGCAATTCCCGCCGCCGGCCGCCAGAGGAAGCTGCTTTGCTGCTGTCGTTGCCCAGCAACTCGTAGCCCGGAAGCAGT
ACCCCGTCTCGCTCGGTTCCGCGGCGGCCACGCTCCGGGAGACTTCCGGCAGGGCGGGCGCGGGGTCTTGGCGAACGGTCTTCGGAAGCG
GCGGCGGCGCGATGACCACGCTACGGGCCTTTACCTGCGACGACCTGTTCCGCTTCAACAACATTAACTTGGATCCACTTACAGAAACTT
ATGGGATTCCTTTCTACCTACAATACCTCGCCCACTGGCCAGAGTATTTCATTGTTGCAGAGGCACCTGGTGGAGAATTAATGGGTTATA
TTATGGGTAAAGCAGAAGGCTCAGTAGCTAGGGAAGAATGGCACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTG
GTTTGGCTGCTAAACTTATGGAGTTACTAGAGGAGATTTCAGAAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACC
AAGTTGCAGTTAACATGTACAAGCAGTTGGGCTACAGTGTATATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATG
AGGACGCTTATGGTCCTGACACTAAACTAATGCAGAATAGTGGTAAGACAAAGTTTAAAAGGACAAGCATTGATAGATTGATGAATACTC
TAGTACTATGGATTTTTGGGTTTCTGATATGCTTGGGAATTATTCTTGCAATAGGAAATTCAATCTGGGAGAGTCAAACTGGGGACCAAT
TCAGAACTTTCCTCTTTTGGAATGAAGGAGAGAAGAGCTCTGTGTTCTCCGGATTCTTAACATTCTGGTCATATATTATTATTCTCAATA
CAGTTGTACCCATTTCCTTATATGTGAGTGTGGAAGTAATTCGTCTAGGACACAGTTATTTTATAAACTGGGACCGGAAGATGTATTATT
CTCGAAAAGCAATACCTGCAGTGGCTCGAACGACCACGCTCAATGAGGAACTGGGGCAGATTGAGTACATTTTCTCCGACAAAACGGGTA
CCCTCACTCAAAACATCATGACCTTTAAAAGATGTTCCATTAATGGGAGAATCTATGGTGAAGTACATGATGACCTGGATCAGAAGACAG
AAATAACTCAGGAAAAAGAGCCTGTGGATTTCTCAGTCAAATCTCAAGCGGATAGAGAATTTCAGTTCTTTGACCACCATCTGATGGAAT
CCATTAAAATGGGTGATCCCAAAGTTCATGAATTCCTTAGGTTACTTGCTCTCTGCCACACTGTAATGTCAGAAGAGAATAGCGCAGGAG
AGCTGATTTACCAAGTTCAGTCACCTGATGAAGGGGCTCTAGTGACTGCCGCTAGAAATTTTGGGTTCATTTTTAAATCCCGGACCCCAG
AGACCATAACAATAGAAGAATTGGGAACACTAGTTACTTATCAATTACTTGCCTTTTTGGATTTCAACAACACCAGAAAAAGGATGTCTG
TCATAGTTCGAAACCCAGAAGGACAGATAAAGCTTTATTCCAAAGGAGCAGATACTATTCTGTTTGAAAAACTTCATCCTTCCAATGAAG
TCCTTTTGTCTTTGACGTCAGACCACCTCAGTGAATTTGCAGGGGAAGGCCTTCGGACCTTGGCCATCGCATACAGAGACCTGGATGACA
AGTACTTTAAAGAGTGGCATAAGATGCTTGAAGATGCGAATGCTGCCACAGAAGAGAGGGATGAACGAATAGCTGGGCTATATGAAGAAA
TTGAAAGAGATTTGATGCTACTAGGTGCCACTGCTGTAGAAGATAAGTTACAGGAGGGTGTTATTGAAACAGTTACAAGTTTATCACTAG
CCAATATTAAGATCTGGGTCCTAACAGGAGACAAACAAGAAACTGCCATCAACATCGGTTATGCCTGCAACATGCTGACTGACGACATGA
ATGATGTGTTTGTGATAGCAGGGAATAATGCTGTGGAAGTGAGAGAAGAACTCAGGAAAGCAAAACAAAATTTGTTTGGACAAAACAGAA
ATTTTTCCAATGGCCATGTAGTTTGTGAAAAAAAGCAGCAGCTGGAGTTGGATTCTATTGTAGAAGAAACCATAACAGGAGATTATGCCT
TAATCATAAATGGCCACAGTTTGGCTCATGCCCTAGAAAGTGATGTCAAGAATGATCTCCTAGAACTTGCTTGCATGTGTAAGACTGTAA
TTTGCTGCAGGGTCACTCCACTCCAGAAAGCCCAAGTGGTAGAGCTGGTGAAGAAGTACAGAAATGCTGTTACTTTGGCCATTGGTGATG
GAGCCAATGATGTCAGCATGATTAAAAGTGCTCACATTGGTGTTGGCATCAGCGGCCAGGAAGGATTGCAAGCAGTCTTAGCCAGCGACT
ATTCATTTGCACAGTTTAGATATCTCCAAAGGCTTCTCCTTGTTCATGGAAGGTGGTCTTATTTCCGAATGTGCAAATTCTTATGCTATT
TCTTCTATAAGAATTTTGCATTTACACTTGTGCATTTCTGGTTTGGTTTCTTCTGTGGTTTCTCAGCCCAGACTGTTTATGACCAGTGGT
TCATCACCCTTTTTAACATTGTTTACACATCACTGCCTGTTTTAGCCATGGGGATTTTTGACCAGGATGTGAGTGACCAGAACAGCGTGG
ACTGTCCCCAGCTCTACAAACCAGGACAGCTGAATCTGCTTTTTAACAAGCGTAAATTTTTCATTTGCGTGTTGCATGGAATCTACACCT
CATTAGTCCTTTTCTTCATCCCCTATGGGGCCTTTTACAACGTGGCTGGAGAAGATGGGCAACATATTGCTGACTACCAGTCCTTTGCAG
TTACCATGGCCACATCTTTGGTCATTGTGGTCAGTGTGCAGATAGCCTTGGATACCAGTTACTGGACTTTCATTAATCACGTCTTCATCT
GGGGGAGCATTGCCATTTATTTCTCCATTTTATTTACAATGCACAGTAATGGCATCTTTGGCATCTTCCCAAACCAGTTTCCATTTGTTG
GTAATGCACGACATTCCCTGACCCAGAAGTGCATCTGGCTTGTAATTCTCTTAACAACAGTGGCTTCAGTTATGCCAGTGGTGGCATTCA
GATTTTTGAAGGTGGATTTATACCCAACCCTGAGTGATCAGATCCGCCGGTGGCAGAAGGCTCAAAAGAAGGCAAGGCCTCCAAGTAGCC
GAAGGCCTCGGACCCGCAGGTCAAGCTCAAGAAGGTCTGGCTATGCTTTTGCTCACCAAGAAGGCTATGGAGAGCTTATCACATCTGGAA
AAAATATGCGAGCTAAAAATCCACCCCCAACATCAGGGCTGGAAAAGACACATTATAATAGCACTAGCTGGATTGAAAATTTATGTAAGA
AAACCACAGACACCGTGAGCAGCTTTAGCCAGGATAAAACAGTGAAACTGTGAGTCAATATGAATTTAAACCACGTAGTTATCTTTTCAC
TTCAGGTGGAGCTGAAATTCTGCTGGCTCCAGAGTTTGAGATTTGAGGCAAGAGGTGGGGCAGGCAGATTGCCTCACTTAACTTAAATCT
GCGGCAGACAACTGCCAGTGCCCATCAAACAGGAGTGTGCGCTATGGAAAACCAGGCCAGAGGGTCACTGTCTGGTTTGTGATTTGGTGG
ACAAAACACTCGCTGTTACAAGTACAGATTTTTTTTTTTTTTAAATCAACCTAGATACCAATTGACCTGAACTTTAGAATCTTATTTATG
GAGAAAAACTTGTAAAGCTGCATATTCACTGAATGGATCCTCAGGCGGATAAAAGGGTGCATTTTAAAGGTATATATCCAAGCTGAAAAG
CATGCCTATTGACAGATAAACATGTATCTGTAAGATCAGCCTTTCCCAAGGTATACTTTTAAAATTTAAAGCGTGTACTGTGTTGCTTTC
AGACTGAGTTGCATGTCACTCTTTAGTCTTGATATCTACCTGTCTGTTCAGCCAGGACAACAAATGGCTTCCAAGCCTGAAGAATACAAA
AGTGTGCTTGTGTTTCTCATTTTTATACCAGTCTAGGGACAAAGGAGACTGAACATCTTTGCAGCAGGATAGGCTGGTAATTTGATCAAA
TTTATTCAAAAAGCTCTCAGTCTGTGTCATGTAAGGACATGCTTATGAAATGTGAGAGAGGCTCGCCACTAAGTATTCTAAATACTTTTC
AATGGCTTTTCTAACAACCTCAGTAGTAATTTGCTGAGCATCATCCAGACCATTAATAGAATCAGCAAAGCACTGGAATTTCACACTTTA
ATGATAATATTCCACATAGTCTATGGGCAAATATTTTCAACATTTCCAATTTTTAAAGCTTCAGAATTGAAGCCAAACAAATTAATAAAT
AATTGTTTTAATTACTATTTAAAAACTCAGGTTTAGATTGTTTAAAATTAGTTGCTTTTGATACTCAGCTGTCATGTTTATAATTCAAAC
ATGTAGTAAACATATGTAGGTAAGGTTGTTTTTTTGGAGATGTTGCAGCTCAAATTTCAGTCCACATATGAATCATCAGTGTATTTTCCA
TAAAGTGATTCGGGCATATTTGTGTGAAAACCTCAGTTCTGTCACTTCTTACCTCTATAAACTTGGACGATAATGTGCCTTCTCTGAGAC
TCAGTTTCTTCCTCTGTAAAATGAGGACATACTACCTACCTCATGTGGTTGGTTGATGATTGTCTGTCAAAGCACAAACTCTGAAATTAT
TAAAAACATAATTATTTCATAAACAGATGAGTTAAGTTCCAGTTAACTCAACATCAGTATAACAGAGCAATTGGAAGAGAATATGAAAAA
ACTGGAATCTAAATAGTCAGTGAGGAAGGCTTTGATAAAATGAAATTGCCAGAAAGATATAAAACTGGTTAGGGTCCTACAGGGAAATAA
AATTATAACCGTGGAGGTACATTTCTCTACCAGAAAGCAAAAATAAAGCATCATGTCTTAATGGTTTTCTACAAATCAACTTCTAATTCT
ACAGAGTCCTTAATCTGGTCCCTATTAAATTCTTGGTCAGACAAAGTTACATTTCCCAAGAGAGTCAGGTGACACTTGAGTGAGTTTGAT
GGATAATGAGCTAATGTGATATCTATAGGTCACAATTTTTTAAAACCAAAATTTTCAAGTCTGGGATAATCTTTCCTAAATGGGATCAAA
TGAAATAATATGTGTAAAAGAGTCAAATGCAGTCCTTTACCATAGTAACTGCCTATGGACGTTGTCTTTCCCTTACATGCCTGCCTACAC
TTAACCAGATGTTGGTTTTCAATGTCTAATTTGTCATTAGTTTCACCACATTTGCTCACTTTTTGTAACATTTTTGCAAGATTTGAAAAC

>56958_56958_1_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000334982_ATP8B4_chr15_50273491_ENST00000284509_length(amino acids)=1177AA_BP=234
MQPLPGRGSEVLGSHSPGGLTGATWQFPPPAARGSCFAAVVAQQLVARKQYPVSLGSAAATLRETSGRAGAGSWRTVFGSGGGAMTTLRA
FTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELL
EEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLI
CLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVAR
TTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVH
EFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQI
KLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGA
TAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCE
KKQQLELDSIVEETITGDYALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKS
AHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYT
SLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIV
VSVQIALDTSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPT
LSDQIRRWQKAQKKARPPSSRRPRTRRSSSRRSGYAFAHQEGYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFS

--------------------------------------------------------------
>56958_56958_2_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000334982_ATP8B4_chr15_50273491_ENST00000559829_length(transcript)=4757nt_BP=732nt
TTTCCTTCCCAGGTGTCGCCGCCTGCTTTCTGCAGCCGCTGCCTGGGAGGGGTTCCGAGGTTCTGGGCAGCCACAGCCCCGGAGGCCTTA
CAGGAGCGACCTGGCAATTCCCGCCGCCGGCCGCCAGAGGAAGCTGCTTTGCTGCTGTCGTTGCCCAGCAACTCGTAGCCCGGAAGCAGT
ACCCCGTCTCGCTCGGTTCCGCGGCGGCCACGCTCCGGGAGACTTCCGGCAGGGCGGGCGCGGGGTCTTGGCGAACGGTCTTCGGAAGCG
GCGGCGGCGCGATGACCACGCTACGGGCCTTTACCTGCGACGACCTGTTCCGCTTCAACAACATTAACTTGGATCCACTTACAGAAACTT
ATGGGATTCCTTTCTACCTACAATACCTCGCCCACTGGCCAGAGTATTTCATTGTTGCAGAGGCACCTGGTGGAGAATTAATGGGTTATA
TTATGGGTAAAGCAGAAGGCTCAGTAGCTAGGGAAGAATGGCACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTG
GTTTGGCTGCTAAACTTATGGAGTTACTAGAGGAGATTTCAGAAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACC
AAGTTGCAGTTAACATGTACAAGCAGTTGGGCTACAGTGTATATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATG
AGGACGCTTATGGTCCTGACACTAAACTAATGCAGAATAGTGGTAAGACAAAGTTTAAAAGGACAAGCATTGATAGATTGATGAATACTC
TAGTACTATGGATTTTTGGGTTTCTGATATGCTTGGGAATTATTCTTGCAATAGGAAATTCAATCTGGGAGAGTCAAACTGGGGACCAAT
TCAGAACTTTCCTCTTTTGGAATGAAGGAGAGAAGAGCTCTGTGTTCTCCGGATTCTTAACATTCTGGTCATATATTATTATTCTCAATA
CAGTTGTACCCATTTCCTTATATGTGAGTGTGGAAGTAATTCGTCTAGGACACAGTTATTTTATAAACTGGGACCGGAAGATGTATTATT
CTCGAAAAGCAATACCTGCAGTGGCTCGAACGACCACGCTCAATGAGGAACTGGGGCAGATTGAGTACATTTTCTCCGACAAAACGGGTA
CCCTCACTCAAAACATCATGACCTTTAAAAGATGTTCCATTAATGGGAGAATCTATGGTGAAGTACATGATGACCTGGATCAGAAGACAG
AAATAACTCAGGAAAAAGAGCCTGTGGATTTCTCAGTCAAATCTCAAGCGGATAGAGAATTTCAGTTCTTTGACCACCATCTGATGGAAT
CCATTAAAATGGGTGATCCCAAAGTTCATGAATTCCTTAGGTTACTTGCTCTCTGCCACACTGTAATGTCAGAAGAGAATAGCGCAGGAG
AGCTGATTTACCAAGTTCAGTCACCTGATGAAGGGGCTCTAGTGACTGCCGCTAGAAATTTTGGGTTCATTTTTAAATCCCGGACCCCAG
AGACCATAACAATAGAAGAATTGGGAACACTAGTTACTTATCAATTACTTGCCTTTTTGGATTTCAACAACACCAGAAAAAGGATGTCTG
TCATAGTTCGAAACCCAGAAGGACAGATAAAGCTTTATTCCAAAGGAGCAGATACTATTCTGTTTGAAAAACTTCATCCTTCCAATGAAG
TCCTTTTGTCTTTGACGTCAGACCACCTCAGTGAATTTGCAGGGGAAGGCCTTCGGACCTTGGCCATCGCATACAGAGACCTGGATGACA
AGTACTTTAAAGAGTGGCATAAGATGCTTGAAGATGCGAATGCTGCCACAGAAGAGAGGGATGAACGAATAGCTGGGCTATATGAAGAAA
TTGAAAGAGATTTGATGCTACTAGGTGCCACTGCTGTAGAAGATAAGTTACAGGAGGGTGTTATTGAAACAGTTACAAGTTTATCACTAG
CCAATATTAAGATCTGGGTCCTAACAGGAGACAAACAAGAAACTGCCATCAACATCGGTTATGCCTGCAACATGCTGACTGACGACATGA
ATGATGTGTTTGTGATAGCAGGGAATAATGCTGTGGAAGTGAGAGAAGAACTCAGGAAAGCAAAACAAAATTTGTTTGGACAAAACAGAA
ATTTTTCCAATGGCCATGTAGTTTGTGAAAAAAAGCAGCAGCTGGAGTTGGATTCTATTGTAGAAGAAACCATAACAGGAGATTATGCCT
TAATCATAAATGGCCACAGTTTGGCTCATGCCCTAGAAAGTGATGTCAAGAATGATCTCCTAGAACTTGCTTGCATGTGTAAGACTGTAA
TTTGCTGCAGGGTCACTCCACTCCAGAAAGCCCAAGTGGTAGAGCTGGTGAAGAAGTACAGAAATGCTGTTACTTTGGCCATTGGTGATG
GAGCCAATGATGTCAGCATGATTAAAAGTGCTCACATTGGTGTTGGCATCAGCGGCCAGGAAGGATTGCAAGCAGTCTTAGCCAGCGACT
ATTCATTTGCACAGTTTAGATATCTCCAAAGGCTTCTCCTTGTTCATGGAAGGTGGTCTTATTTCCGAATGTGCAAATTCTTATGCTATT
TCTTCTATAAGAATTTTGCATTTACACTTGTGCATTTCTGGTTTGGTTTCTTCTGTGGTTTCTCAGCCCAGACTGTTTATGACCAGTGGT
TCATCACCCTTTTTAACATTGTTTACACATCACTGCCTGTTTTAGCCATGGGGATTTTTGACCAGGATGTGAGTGACCAGAACAGCGTGG
ACTGTCCCCAGCTCTACAAACCAGGACAGCTGAATCTGCTTTTTAACAAGCGTAAATTTTTCATTTGCGTGTTGCATGGAATCTACACCT
CATTAGTCCTTTTCTTCATCCCCTATGGGGCCTTTTACAACGTGGCTGGAGAAGATGGGCAACATATTGCTGACTACCAGTCCTTTGCAG
TTACCATGGCCACATCTTTGGTCATTGTGGTCAGTGTGCAGATAGCCTTGGATACCAGTTACTGGACTTTCATTAATCACGTCTTCATCT
GGGGGAGCATTGCCATTTATTTCTCCATTTTATTTACAATGCACAGTAATGGCATCTTTGGCATCTTCCCAAACCAGTTTCCATTTGTTG
GTAATGCACGACATTCCCTGACCCAGAAGTGCATCTGGCTTGTAATTCTCTTAACAACAGTGGCTTCAGTTATGCCAGTGGTGGCATTCA
GATTTTTGAAGGTGGATTTATACCCAACCCTGAGTGATCAGATCCGCCGGTGGCAGAAGGCTCAAAAGAAGGCAAGGCCTCCAAGTAGCC
GAAGGCCTCGGACCCGCAGGTCAAGCTCAAGAAGGTCTGGCTATGCTTTTGCTCACCAAGAAGGCTATGGAGAGCTTATCACATCTGGAA
AAAATATGCGAGCTAAAAATCCACCCCCAACATCAGGGCTGGAAAAGACACATTATAATAGCACTAGCTGGATTGAAAATTTATGTAAGA
AAACCACAGACACCGTGAGCAGCTTTAGCCAGGATAAAACAGTGAAACTGTGAGTCAATATGAATTTAAACCACGTAGTTATCTTTTCAC
TTCAGGTGGAGCTGAAATTCTGCTGGCTCCAGAGTTTGAGATTTGAGGCAAGAGGTGGGGCAGGCAGATTGCCTCACTTAACTTAAATCT
GCGGCAGACAACTGCCAGTGCCCATCAAACAGGAGTGTGCGCTATGGAAAACCAGGCCAGAGGGTCACTGTCTGGTTTGTGATTTGGTGG
ACAAAACACTCGCTGTTACAAGTACAGATTTTTTTTTTTTTTAAATCAACCTAGATACCAATTGACCTGAACTTTAGAATCTTATTTATG
GAGAAAAACTTGTAAAGCTGCATATTCACTGAATGGATCCTCAGGCGGATAAAAGGGTGCATTTTAAAGGTATATATCCAAGCTGAAAAG
CATGCCTATTGACAGATAAACATGTATCTGTAAGATCAGCCTTTCCCAAGGTATACTTTTAAAATTTAAAGCGTGTACTGTGTTGCTTTC
AGACTGAGTTGCATGTCACTCTTTAGTCTTGATATCTACCTGTCTGTTCAGCCAGGACAACAAATGGCTTCCAAGCCTGAAGAATACAAA
AGTGTGCTTGTGTTTCTCATTTTTATACCAGTCTAGGGACAAAGGAGACTGAACATCTTTGCAGCAGGATAGGCTGGTAATTTGATCAAA
TTTATTCAAAAAGCTCTCAGTCTGTGTCATGTAAGGACATGCTTATGAAATGTGAGAGAGGCTCGCCACTAAGTATTCTAAATACTTTTC
AATGGCTTTTCTAACAACCTCAGTAGTAATTTGCTGAGCATCATCCAGACCATTAATAGAATCAGCAAAGCACTGGAATTTCACACTTTA
ATGATAATATTCCACATAGTCTATGGGCAAATATTTTCAACATTTCCAATTTTTAAAGCTTCAGAATTGAAGCCAAACAAATTAATAAAT
AATTGTTTTAATTACTATTTAAAAACTCAGGTTTAGATTGTTTAAAATTAGTTGCTTTTGATACTCAGCTGTCATGTTTATAATTCAAAC
ATGTAGTAAACATATGTAGGTAAGGTTGTTTTTTTGGAGATGTTGCAGCTCAAATTTCAGTCCACATATGAATCATCAGTGTATTTTCCA

>56958_56958_2_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000334982_ATP8B4_chr15_50273491_ENST00000559829_length(amino acids)=1177AA_BP=234
MQPLPGRGSEVLGSHSPGGLTGATWQFPPPAARGSCFAAVVAQQLVARKQYPVSLGSAAATLRETSGRAGAGSWRTVFGSGGGAMTTLRA
FTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELL
EEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLI
CLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVAR
TTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVH
EFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQI
KLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGA
TAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCE
KKQQLELDSIVEETITGDYALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKS
AHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYT
SLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIV
VSVQIALDTSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPT
LSDQIRRWQKAQKKARPPSSRRPRTRRSSSRRSGYAFAHQEGYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFS

--------------------------------------------------------------
>56958_56958_3_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000398602_ATP8B4_chr15_50273491_ENST00000284509_length(transcript)=5837nt_BP=1050nt
CGGCGCGATGACCACGCTACGGGCCTTTACCTGCGACGACCTGTTCCGCTTCAACAACATGTGAGTGACACGCGCCTAGGGCCAGCCGCT
CTTGGCCGGGCCTCGCTTCCCGGCCCCGCCAGCTCCGGCCCCAGCCGCGCCTTCCCGGCCGGACCCCAAGCCCGGACGGGGACCCGCGAG
AACCACCCCCCGCCGGCCAACGTGGGCGCCTCCCTGGGGCCACAGGGTCCAGGGAGAGGTGGGCCTGGAGTCGACGCACGCCGGCCTTGG
CGACCTTGGCCGAGGTGCTCAAACTTTGTCTCTGGACCCTGCGAGCTGGCAGGTTCTGGGGCAGCGCTCGGGCCTCCGCTCGTGGTCGCT
GTCAGGAGGCGCTGGGGTGATGGGGCGAGCTGGAGACGCGGCCTGGAGCCCACGACCTGGGCTTCTCGCCCTGCCCTACTGCTTGCTGGT
TCGTGGCCGGGCCGCGCCTCTTCTGGGCAGAGGGCACCGCCGACGGCCAGGCCGCAGAGGGGGCTTGCGAGGATCGGAAGCTGGTCAGCA
GCTGTTGGGATGTGTACATCGTGAAGCCCACCTGGTGGCCGTGGTTAAATTGTATCCAAATGAAATGACACTGATCACTGCGTCCCCTGC
AGCAGATGCTGTCTCAGTCATGTAACTTGGATCCACTTACAGAAACTTATGGGATTCCTTTCTACCTACAATACCTCGCCCACTGGCCAG
AGTATTTCATTGTTGCAGAGGCACCTGGTGGAGAATTAATGGGTTATATTATGGGTAAAGCAGAAGGCTCAGTAGCTAGGGAAGAATGGC
ACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTGGTTTGGCTGCTAAACTTATGGAGTTACTAGAGGAGATTTCAG
AAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACCAAGTTGCAGTTAACATGTACAAGCAGTTGGGCTACAGTGTAT
ATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATGAGGACGCTTATGGTCCTGACACTAAACTAATGCAGAATAGTG
GTAAGACAAAGTTTAAAAGGACAAGCATTGATAGATTGATGAATACTCTAGTACTATGGATTTTTGGGTTTCTGATATGCTTGGGAATTA
TTCTTGCAATAGGAAATTCAATCTGGGAGAGTCAAACTGGGGACCAATTCAGAACTTTCCTCTTTTGGAATGAAGGAGAGAAGAGCTCTG
TGTTCTCCGGATTCTTAACATTCTGGTCATATATTATTATTCTCAATACAGTTGTACCCATTTCCTTATATGTGAGTGTGGAAGTAATTC
GTCTAGGACACAGTTATTTTATAAACTGGGACCGGAAGATGTATTATTCTCGAAAAGCAATACCTGCAGTGGCTCGAACGACCACGCTCA
ATGAGGAACTGGGGCAGATTGAGTACATTTTCTCCGACAAAACGGGTACCCTCACTCAAAACATCATGACCTTTAAAAGATGTTCCATTA
ATGGGAGAATCTATGGTGAAGTACATGATGACCTGGATCAGAAGACAGAAATAACTCAGGAAAAAGAGCCTGTGGATTTCTCAGTCAAAT
CTCAAGCGGATAGAGAATTTCAGTTCTTTGACCACCATCTGATGGAATCCATTAAAATGGGTGATCCCAAAGTTCATGAATTCCTTAGGT
TACTTGCTCTCTGCCACACTGTAATGTCAGAAGAGAATAGCGCAGGAGAGCTGATTTACCAAGTTCAGTCACCTGATGAAGGGGCTCTAG
TGACTGCCGCTAGAAATTTTGGGTTCATTTTTAAATCCCGGACCCCAGAGACCATAACAATAGAAGAATTGGGAACACTAGTTACTTATC
AATTACTTGCCTTTTTGGATTTCAACAACACCAGAAAAAGGATGTCTGTCATAGTTCGAAACCCAGAAGGACAGATAAAGCTTTATTCCA
AAGGAGCAGATACTATTCTGTTTGAAAAACTTCATCCTTCCAATGAAGTCCTTTTGTCTTTGACGTCAGACCACCTCAGTGAATTTGCAG
GGGAAGGCCTTCGGACCTTGGCCATCGCATACAGAGACCTGGATGACAAGTACTTTAAAGAGTGGCATAAGATGCTTGAAGATGCGAATG
CTGCCACAGAAGAGAGGGATGAACGAATAGCTGGGCTATATGAAGAAATTGAAAGAGATTTGATGCTACTAGGTGCCACTGCTGTAGAAG
ATAAGTTACAGGAGGGTGTTATTGAAACAGTTACAAGTTTATCACTAGCCAATATTAAGATCTGGGTCCTAACAGGAGACAAACAAGAAA
CTGCCATCAACATCGGTTATGCCTGCAACATGCTGACTGACGACATGAATGATGTGTTTGTGATAGCAGGGAATAATGCTGTGGAAGTGA
GAGAAGAACTCAGGAAAGCAAAACAAAATTTGTTTGGACAAAACAGAAATTTTTCCAATGGCCATGTAGTTTGTGAAAAAAAGCAGCAGC
TGGAGTTGGATTCTATTGTAGAAGAAACCATAACAGGAGATTATGCCTTAATCATAAATGGCCACAGTTTGGCTCATGCCCTAGAAAGTG
ATGTCAAGAATGATCTCCTAGAACTTGCTTGCATGTGTAAGACTGTAATTTGCTGCAGGGTCACTCCACTCCAGAAAGCCCAAGTGGTAG
AGCTGGTGAAGAAGTACAGAAATGCTGTTACTTTGGCCATTGGTGATGGAGCCAATGATGTCAGCATGATTAAAAGTGCTCACATTGGTG
TTGGCATCAGCGGCCAGGAAGGATTGCAAGCAGTCTTAGCCAGCGACTATTCATTTGCACAGTTTAGATATCTCCAAAGGCTTCTCCTTG
TTCATGGAAGGTGGTCTTATTTCCGAATGTGCAAATTCTTATGCTATTTCTTCTATAAGAATTTTGCATTTACACTTGTGCATTTCTGGT
TTGGTTTCTTCTGTGGTTTCTCAGCCCAGACTGTTTATGACCAGTGGTTCATCACCCTTTTTAACATTGTTTACACATCACTGCCTGTTT
TAGCCATGGGGATTTTTGACCAGGATGTGAGTGACCAGAACAGCGTGGACTGTCCCCAGCTCTACAAACCAGGACAGCTGAATCTGCTTT
TTAACAAGCGTAAATTTTTCATTTGCGTGTTGCATGGAATCTACACCTCATTAGTCCTTTTCTTCATCCCCTATGGGGCCTTTTACAACG
TGGCTGGAGAAGATGGGCAACATATTGCTGACTACCAGTCCTTTGCAGTTACCATGGCCACATCTTTGGTCATTGTGGTCAGTGTGCAGA
TAGCCTTGGATACCAGTTACTGGACTTTCATTAATCACGTCTTCATCTGGGGGAGCATTGCCATTTATTTCTCCATTTTATTTACAATGC
ACAGTAATGGCATCTTTGGCATCTTCCCAAACCAGTTTCCATTTGTTGGTAATGCACGACATTCCCTGACCCAGAAGTGCATCTGGCTTG
TAATTCTCTTAACAACAGTGGCTTCAGTTATGCCAGTGGTGGCATTCAGATTTTTGAAGGTGGATTTATACCCAACCCTGAGTGATCAGA
TCCGCCGGTGGCAGAAGGCTCAAAAGAAGGCAAGGCCTCCAAGTAGCCGAAGGCCTCGGACCCGCAGGTCAAGCTCAAGAAGGTCTGGCT
ATGCTTTTGCTCACCAAGAAGGCTATGGAGAGCTTATCACATCTGGAAAAAATATGCGAGCTAAAAATCCACCCCCAACATCAGGGCTGG
AAAAGACACATTATAATAGCACTAGCTGGATTGAAAATTTATGTAAGAAAACCACAGACACCGTGAGCAGCTTTAGCCAGGATAAAACAG
TGAAACTGTGAGTCAATATGAATTTAAACCACGTAGTTATCTTTTCACTTCAGGTGGAGCTGAAATTCTGCTGGCTCCAGAGTTTGAGAT
TTGAGGCAAGAGGTGGGGCAGGCAGATTGCCTCACTTAACTTAAATCTGCGGCAGACAACTGCCAGTGCCCATCAAACAGGAGTGTGCGC
TATGGAAAACCAGGCCAGAGGGTCACTGTCTGGTTTGTGATTTGGTGGACAAAACACTCGCTGTTACAAGTACAGATTTTTTTTTTTTTT
AAATCAACCTAGATACCAATTGACCTGAACTTTAGAATCTTATTTATGGAGAAAAACTTGTAAAGCTGCATATTCACTGAATGGATCCTC
AGGCGGATAAAAGGGTGCATTTTAAAGGTATATATCCAAGCTGAAAAGCATGCCTATTGACAGATAAACATGTATCTGTAAGATCAGCCT
TTCCCAAGGTATACTTTTAAAATTTAAAGCGTGTACTGTGTTGCTTTCAGACTGAGTTGCATGTCACTCTTTAGTCTTGATATCTACCTG
TCTGTTCAGCCAGGACAACAAATGGCTTCCAAGCCTGAAGAATACAAAAGTGTGCTTGTGTTTCTCATTTTTATACCAGTCTAGGGACAA
AGGAGACTGAACATCTTTGCAGCAGGATAGGCTGGTAATTTGATCAAATTTATTCAAAAAGCTCTCAGTCTGTGTCATGTAAGGACATGC
TTATGAAATGTGAGAGAGGCTCGCCACTAAGTATTCTAAATACTTTTCAATGGCTTTTCTAACAACCTCAGTAGTAATTTGCTGAGCATC
ATCCAGACCATTAATAGAATCAGCAAAGCACTGGAATTTCACACTTTAATGATAATATTCCACATAGTCTATGGGCAAATATTTTCAACA
TTTCCAATTTTTAAAGCTTCAGAATTGAAGCCAAACAAATTAATAAATAATTGTTTTAATTACTATTTAAAAACTCAGGTTTAGATTGTT
TAAAATTAGTTGCTTTTGATACTCAGCTGTCATGTTTATAATTCAAACATGTAGTAAACATATGTAGGTAAGGTTGTTTTTTTGGAGATG
TTGCAGCTCAAATTTCAGTCCACATATGAATCATCAGTGTATTTTCCATAAAGTGATTCGGGCATATTTGTGTGAAAACCTCAGTTCTGT
CACTTCTTACCTCTATAAACTTGGACGATAATGTGCCTTCTCTGAGACTCAGTTTCTTCCTCTGTAAAATGAGGACATACTACCTACCTC
ATGTGGTTGGTTGATGATTGTCTGTCAAAGCACAAACTCTGAAATTATTAAAAACATAATTATTTCATAAACAGATGAGTTAAGTTCCAG
TTAACTCAACATCAGTATAACAGAGCAATTGGAAGAGAATATGAAAAAACTGGAATCTAAATAGTCAGTGAGGAAGGCTTTGATAAAATG
AAATTGCCAGAAAGATATAAAACTGGTTAGGGTCCTACAGGGAAATAAAATTATAACCGTGGAGGTACATTTCTCTACCAGAAAGCAAAA
ATAAAGCATCATGTCTTAATGGTTTTCTACAAATCAACTTCTAATTCTACAGAGTCCTTAATCTGGTCCCTATTAAATTCTTGGTCAGAC
AAAGTTACATTTCCCAAGAGAGTCAGGTGACACTTGAGTGAGTTTGATGGATAATGAGCTAATGTGATATCTATAGGTCACAATTTTTTA
AAACCAAAATTTTCAAGTCTGGGATAATCTTTCCTAAATGGGATCAAATGAAATAATATGTGTAAAAGAGTCAAATGCAGTCCTTTACCA
TAGTAACTGCCTATGGACGTTGTCTTTCCCTTACATGCCTGCCTACACTTAACCAGATGTTGGTTTTCAATGTCTAATTTGTCATTAGTT

>56958_56958_3_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000398602_ATP8B4_chr15_50273491_ENST00000284509_length(amino acids)=1087AA_BP=144
MRPLQQMLSQSCNLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELL
EEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLI
CLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVAR
TTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVH
EFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQI
KLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGA
TAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCE
KKQQLELDSIVEETITGDYALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKS
AHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYT
SLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIV
VSVQIALDTSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPT
LSDQIRRWQKAQKKARPPSSRRPRTRRSSSRRSGYAFAHQEGYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFS

--------------------------------------------------------------
>56958_56958_4_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000398602_ATP8B4_chr15_50273491_ENST00000559829_length(transcript)=5075nt_BP=1050nt
CGGCGCGATGACCACGCTACGGGCCTTTACCTGCGACGACCTGTTCCGCTTCAACAACATGTGAGTGACACGCGCCTAGGGCCAGCCGCT
CTTGGCCGGGCCTCGCTTCCCGGCCCCGCCAGCTCCGGCCCCAGCCGCGCCTTCCCGGCCGGACCCCAAGCCCGGACGGGGACCCGCGAG
AACCACCCCCCGCCGGCCAACGTGGGCGCCTCCCTGGGGCCACAGGGTCCAGGGAGAGGTGGGCCTGGAGTCGACGCACGCCGGCCTTGG
CGACCTTGGCCGAGGTGCTCAAACTTTGTCTCTGGACCCTGCGAGCTGGCAGGTTCTGGGGCAGCGCTCGGGCCTCCGCTCGTGGTCGCT
GTCAGGAGGCGCTGGGGTGATGGGGCGAGCTGGAGACGCGGCCTGGAGCCCACGACCTGGGCTTCTCGCCCTGCCCTACTGCTTGCTGGT
TCGTGGCCGGGCCGCGCCTCTTCTGGGCAGAGGGCACCGCCGACGGCCAGGCCGCAGAGGGGGCTTGCGAGGATCGGAAGCTGGTCAGCA
GCTGTTGGGATGTGTACATCGTGAAGCCCACCTGGTGGCCGTGGTTAAATTGTATCCAAATGAAATGACACTGATCACTGCGTCCCCTGC
AGCAGATGCTGTCTCAGTCATGTAACTTGGATCCACTTACAGAAACTTATGGGATTCCTTTCTACCTACAATACCTCGCCCACTGGCCAG
AGTATTTCATTGTTGCAGAGGCACCTGGTGGAGAATTAATGGGTTATATTATGGGTAAAGCAGAAGGCTCAGTAGCTAGGGAAGAATGGC
ACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTGGTTTGGCTGCTAAACTTATGGAGTTACTAGAGGAGATTTCAG
AAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACCAAGTTGCAGTTAACATGTACAAGCAGTTGGGCTACAGTGTAT
ATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATGAGGACGCTTATGGTCCTGACACTAAACTAATGCAGAATAGTG
GTAAGACAAAGTTTAAAAGGACAAGCATTGATAGATTGATGAATACTCTAGTACTATGGATTTTTGGGTTTCTGATATGCTTGGGAATTA
TTCTTGCAATAGGAAATTCAATCTGGGAGAGTCAAACTGGGGACCAATTCAGAACTTTCCTCTTTTGGAATGAAGGAGAGAAGAGCTCTG
TGTTCTCCGGATTCTTAACATTCTGGTCATATATTATTATTCTCAATACAGTTGTACCCATTTCCTTATATGTGAGTGTGGAAGTAATTC
GTCTAGGACACAGTTATTTTATAAACTGGGACCGGAAGATGTATTATTCTCGAAAAGCAATACCTGCAGTGGCTCGAACGACCACGCTCA
ATGAGGAACTGGGGCAGATTGAGTACATTTTCTCCGACAAAACGGGTACCCTCACTCAAAACATCATGACCTTTAAAAGATGTTCCATTA
ATGGGAGAATCTATGGTGAAGTACATGATGACCTGGATCAGAAGACAGAAATAACTCAGGAAAAAGAGCCTGTGGATTTCTCAGTCAAAT
CTCAAGCGGATAGAGAATTTCAGTTCTTTGACCACCATCTGATGGAATCCATTAAAATGGGTGATCCCAAAGTTCATGAATTCCTTAGGT
TACTTGCTCTCTGCCACACTGTAATGTCAGAAGAGAATAGCGCAGGAGAGCTGATTTACCAAGTTCAGTCACCTGATGAAGGGGCTCTAG
TGACTGCCGCTAGAAATTTTGGGTTCATTTTTAAATCCCGGACCCCAGAGACCATAACAATAGAAGAATTGGGAACACTAGTTACTTATC
AATTACTTGCCTTTTTGGATTTCAACAACACCAGAAAAAGGATGTCTGTCATAGTTCGAAACCCAGAAGGACAGATAAAGCTTTATTCCA
AAGGAGCAGATACTATTCTGTTTGAAAAACTTCATCCTTCCAATGAAGTCCTTTTGTCTTTGACGTCAGACCACCTCAGTGAATTTGCAG
GGGAAGGCCTTCGGACCTTGGCCATCGCATACAGAGACCTGGATGACAAGTACTTTAAAGAGTGGCATAAGATGCTTGAAGATGCGAATG
CTGCCACAGAAGAGAGGGATGAACGAATAGCTGGGCTATATGAAGAAATTGAAAGAGATTTGATGCTACTAGGTGCCACTGCTGTAGAAG
ATAAGTTACAGGAGGGTGTTATTGAAACAGTTACAAGTTTATCACTAGCCAATATTAAGATCTGGGTCCTAACAGGAGACAAACAAGAAA
CTGCCATCAACATCGGTTATGCCTGCAACATGCTGACTGACGACATGAATGATGTGTTTGTGATAGCAGGGAATAATGCTGTGGAAGTGA
GAGAAGAACTCAGGAAAGCAAAACAAAATTTGTTTGGACAAAACAGAAATTTTTCCAATGGCCATGTAGTTTGTGAAAAAAAGCAGCAGC
TGGAGTTGGATTCTATTGTAGAAGAAACCATAACAGGAGATTATGCCTTAATCATAAATGGCCACAGTTTGGCTCATGCCCTAGAAAGTG
ATGTCAAGAATGATCTCCTAGAACTTGCTTGCATGTGTAAGACTGTAATTTGCTGCAGGGTCACTCCACTCCAGAAAGCCCAAGTGGTAG
AGCTGGTGAAGAAGTACAGAAATGCTGTTACTTTGGCCATTGGTGATGGAGCCAATGATGTCAGCATGATTAAAAGTGCTCACATTGGTG
TTGGCATCAGCGGCCAGGAAGGATTGCAAGCAGTCTTAGCCAGCGACTATTCATTTGCACAGTTTAGATATCTCCAAAGGCTTCTCCTTG
TTCATGGAAGGTGGTCTTATTTCCGAATGTGCAAATTCTTATGCTATTTCTTCTATAAGAATTTTGCATTTACACTTGTGCATTTCTGGT
TTGGTTTCTTCTGTGGTTTCTCAGCCCAGACTGTTTATGACCAGTGGTTCATCACCCTTTTTAACATTGTTTACACATCACTGCCTGTTT
TAGCCATGGGGATTTTTGACCAGGATGTGAGTGACCAGAACAGCGTGGACTGTCCCCAGCTCTACAAACCAGGACAGCTGAATCTGCTTT
TTAACAAGCGTAAATTTTTCATTTGCGTGTTGCATGGAATCTACACCTCATTAGTCCTTTTCTTCATCCCCTATGGGGCCTTTTACAACG
TGGCTGGAGAAGATGGGCAACATATTGCTGACTACCAGTCCTTTGCAGTTACCATGGCCACATCTTTGGTCATTGTGGTCAGTGTGCAGA
TAGCCTTGGATACCAGTTACTGGACTTTCATTAATCACGTCTTCATCTGGGGGAGCATTGCCATTTATTTCTCCATTTTATTTACAATGC
ACAGTAATGGCATCTTTGGCATCTTCCCAAACCAGTTTCCATTTGTTGGTAATGCACGACATTCCCTGACCCAGAAGTGCATCTGGCTTG
TAATTCTCTTAACAACAGTGGCTTCAGTTATGCCAGTGGTGGCATTCAGATTTTTGAAGGTGGATTTATACCCAACCCTGAGTGATCAGA
TCCGCCGGTGGCAGAAGGCTCAAAAGAAGGCAAGGCCTCCAAGTAGCCGAAGGCCTCGGACCCGCAGGTCAAGCTCAAGAAGGTCTGGCT
ATGCTTTTGCTCACCAAGAAGGCTATGGAGAGCTTATCACATCTGGAAAAAATATGCGAGCTAAAAATCCACCCCCAACATCAGGGCTGG
AAAAGACACATTATAATAGCACTAGCTGGATTGAAAATTTATGTAAGAAAACCACAGACACCGTGAGCAGCTTTAGCCAGGATAAAACAG
TGAAACTGTGAGTCAATATGAATTTAAACCACGTAGTTATCTTTTCACTTCAGGTGGAGCTGAAATTCTGCTGGCTCCAGAGTTTGAGAT
TTGAGGCAAGAGGTGGGGCAGGCAGATTGCCTCACTTAACTTAAATCTGCGGCAGACAACTGCCAGTGCCCATCAAACAGGAGTGTGCGC
TATGGAAAACCAGGCCAGAGGGTCACTGTCTGGTTTGTGATTTGGTGGACAAAACACTCGCTGTTACAAGTACAGATTTTTTTTTTTTTT
AAATCAACCTAGATACCAATTGACCTGAACTTTAGAATCTTATTTATGGAGAAAAACTTGTAAAGCTGCATATTCACTGAATGGATCCTC
AGGCGGATAAAAGGGTGCATTTTAAAGGTATATATCCAAGCTGAAAAGCATGCCTATTGACAGATAAACATGTATCTGTAAGATCAGCCT
TTCCCAAGGTATACTTTTAAAATTTAAAGCGTGTACTGTGTTGCTTTCAGACTGAGTTGCATGTCACTCTTTAGTCTTGATATCTACCTG
TCTGTTCAGCCAGGACAACAAATGGCTTCCAAGCCTGAAGAATACAAAAGTGTGCTTGTGTTTCTCATTTTTATACCAGTCTAGGGACAA
AGGAGACTGAACATCTTTGCAGCAGGATAGGCTGGTAATTTGATCAAATTTATTCAAAAAGCTCTCAGTCTGTGTCATGTAAGGACATGC
TTATGAAATGTGAGAGAGGCTCGCCACTAAGTATTCTAAATACTTTTCAATGGCTTTTCTAACAACCTCAGTAGTAATTTGCTGAGCATC
ATCCAGACCATTAATAGAATCAGCAAAGCACTGGAATTTCACACTTTAATGATAATATTCCACATAGTCTATGGGCAAATATTTTCAACA
TTTCCAATTTTTAAAGCTTCAGAATTGAAGCCAAACAAATTAATAAATAATTGTTTTAATTACTATTTAAAAACTCAGGTTTAGATTGTT
TAAAATTAGTTGCTTTTGATACTCAGCTGTCATGTTTATAATTCAAACATGTAGTAAACATATGTAGGTAAGGTTGTTTTTTTGGAGATG
TTGCAGCTCAAATTTCAGTCCACATATGAATCATCAGTGTATTTTCCATAAAGTGATTCGGGCATATTTGTGTGAAAACCTCAGTTCTGT

>56958_56958_4_NAA20-ATP8B4_NAA20_chr20_20013297_ENST00000398602_ATP8B4_chr15_50273491_ENST00000559829_length(amino acids)=1087AA_BP=144
MRPLQQMLSQSCNLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELL
EEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLI
CLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVAR
TTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVH
EFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQI
KLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGA
TAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCE
KKQQLELDSIVEETITGDYALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKS
AHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYT
SLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIV
VSVQIALDTSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPT
LSDQIRRWQKAQKKARPPSSRRPRTRRSSSRRSGYAFAHQEGYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFS

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Fusion Gene PPI Analysis for NAA20-ATP8B4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAA20-ATP8B4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAA20-ATP8B4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource