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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAA30-TERT (FusionGDB2 ID:56978)

Fusion Gene Summary for NAA30-TERT

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA30-TERT
Fusion gene ID: 56978
HgeneTgene
Gene symbol

NAA30

TERT

Gene ID

122830

7015

Gene nameN-alpha-acetyltransferase 30, NatC catalytic subunittelomerase reverse transcriptase
SynonymsC14orf35|MAK3|Mak3p|NAT12|NAT12PCMM9|DKCA2|DKCB4|EST2|PFBMFT1|TCS1|TP2|TRT|hEST2|hTRT
Cytomap

14q22.3

5p15.33

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 30N-acetyltransferase 12 (GCN5-related, putative)N-acetyltransferase MAK3 homolognatC catalytic subunitputative N-acetyltransferasetelomerase reverse transcriptasetelomerase catalytic subunittelomerase-associated protein 2
Modification date2020031320200329
UniProtAcc

Q147X3

.
Ensembl transtripts involved in fusion geneENST00000555166, ENST00000556492, 
ENST00000554703, 		ENST00000522877, 
ENST00000310581, ENST00000334602, 
ENST00000508104, ENST00000296820, 
Fusion gene scores* DoF score1 X 1 X 1=122 X 7 X 15=2310
# samples 131
** MAII scorelog2(1/1*10)=3.32192809488736log2(31/2310*10)=-2.89755273102918
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAA30 [Title/Abstract] AND TERT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAA30(57866601)-TERT(1282739), # samples:3
Anticipated loss of major functional domain due to fusion event.NAA30-TERT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NAA30-TERT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAA30

GO:0017196

N-terminal peptidyl-methionine acetylation

19398576

TgeneTERT

GO:0001172

transcription, RNA-templated

19701182

TgeneTERT

GO:0006278

RNA-dependent DNA biosynthetic process

9398860

TgeneTERT

GO:0007004

telomere maintenance via telomerase

9443919|16043710|17940095|19701182|21531765|29695869

TgeneTERT

GO:0007005

mitochondrion organization

21937513

TgeneTERT

GO:0010629

negative regulation of gene expression

11927518

TgeneTERT

GO:0022616

DNA strand elongation

16043710

TgeneTERT

GO:0030422

production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:0031647

regulation of protein stability

24415760|26194824

TgeneTERT

GO:0032092

positive regulation of protein binding

24415760

TgeneTERT

GO:0051000

positive regulation of nitric-oxide synthase activity

11927518

TgeneTERT

GO:0070200

establishment of protein localization to telomere

25589350

TgeneTERT

GO:0071897

DNA biosynthetic process

9398860|19701182

TgeneTERT

GO:1903704

negative regulation of production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:1904751

positive regulation of protein localization to nucleolus

24415760

TgeneTERT

GO:2000773

negative regulation of cellular senescence

11927518


check buttonFusion gene breakpoints across NAA30 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TERT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-27-1835-01ANAA30chr14

57866601

-TERTchr5

1282739

-
ChimerDB4GBMTCGA-27-1835-01ANAA30chr14

57866601

+TERTchr5

1282739

-


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Fusion Gene ORF analysis for NAA30-TERT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000555166ENST00000522877NAA30chr14

57866601

+TERTchr5

1282739

-
5CDS-intronENST00000556492ENST00000522877NAA30chr14

57866601

+TERTchr5

1282739

-
Frame-shiftENST00000555166ENST00000310581NAA30chr14

57866601

+TERTchr5

1282739

-
Frame-shiftENST00000555166ENST00000334602NAA30chr14

57866601

+TERTchr5

1282739

-
Frame-shiftENST00000555166ENST00000508104NAA30chr14

57866601

+TERTchr5

1282739

-
Frame-shiftENST00000556492ENST00000310581NAA30chr14

57866601

+TERTchr5

1282739

-
Frame-shiftENST00000556492ENST00000334602NAA30chr14

57866601

+TERTchr5

1282739

-
Frame-shiftENST00000556492ENST00000508104NAA30chr14

57866601

+TERTchr5

1282739

-
In-frameENST00000555166ENST00000296820NAA30chr14

57866601

+TERTchr5

1282739

-
In-frameENST00000556492ENST00000296820NAA30chr14

57866601

+TERTchr5

1282739

-
intron-3CDSENST00000554703ENST00000296820NAA30chr14

57866601

+TERTchr5

1282739

-
intron-3CDSENST00000554703ENST00000310581NAA30chr14

57866601

+TERTchr5

1282739

-
intron-3CDSENST00000554703ENST00000334602NAA30chr14

57866601

+TERTchr5

1282739

-
intron-3CDSENST00000554703ENST00000508104NAA30chr14

57866601

+TERTchr5

1282739

-
intron-intronENST00000554703ENST00000522877NAA30chr14

57866601

+TERTchr5

1282739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000555166NAA30chr1457866601+ENST00000296820TERTchr51282739-25403429991985328
ENST00000556492NAA30chr1457866601+ENST00000296820TERTchr51282739-33031105461176376

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000555166ENST00000296820NAA30chr1457866601+TERTchr51282739-0.084263870.91573614
ENST00000556492ENST00000296820NAA30chr1457866601+TERTchr51282739-0.0171265340.9828735

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Fusion Genomic Features for NAA30-TERT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAA30-TERT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:57866601/chr5:1282739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA30

Q147X3

.
FUNCTION: Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate. {ECO:0000269|PubMed:19398576}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAA30chr14:57866601chr5:1282739ENST00000556492+455_30317363.0Compositional biasNote=Pro-rich
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114605_935524445.6666666666667DomainReverse transcriptase
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116605_9355241133.0DomainReverse transcriptase
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115605_9355241070.0DomainReverse transcriptase
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418605_935524808.0DomainReverse transcriptase
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114914_928524445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114936_1132524445.6666666666667RegionNote=CTE
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116914_9285241133.0RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116936_11325241133.0RegionNote=CTE
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115914_9285241070.0RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115936_11325241070.0RegionNote=CTE
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418914_928524808.0RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418936_1132524808.0RegionNote=CTE

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAA30chr14:57866601chr5:1282739ENST00000556492+45214_362317363.0DomainN-acetyltransferase
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114222_240524445.6666666666667MotifNote=Bipartite nuclear localization signal
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114328_333524445.6666666666667MotifTFLY%3B involved in RNA binding
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116222_2405241133.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116328_3335241133.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115222_2405241070.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115328_3335241070.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418222_240524808.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418328_333524808.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr14:57866601chr5:1282739ENST000002968201141_230524445.6666666666667RegionNote=RNA-interacting domain 1
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114231_324524445.6666666666667RegionNote=Linker
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114301_538524445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114325_550524445.6666666666667RegionNote=RNA-interacting domain 2
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114376_521524445.6666666666667RegionNote=QFP motif
TgeneTERTchr14:57866601chr5:1282739ENST00000296820114397_417524445.6666666666667RegionNote=CP motif
TgeneTERTchr14:57866601chr5:1282739ENST0000029682011458_197524445.6666666666667RegionNote=GQ motif
TgeneTERTchr14:57866601chr5:1282739ENST000003105811161_2305241133.0RegionNote=RNA-interacting domain 1
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116231_3245241133.0RegionNote=Linker
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116301_5385241133.0RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116325_5505241133.0RegionNote=RNA-interacting domain 2
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116376_5215241133.0RegionNote=QFP motif
TgeneTERTchr14:57866601chr5:1282739ENST00000310581116397_4175241133.0RegionNote=CP motif
TgeneTERTchr14:57866601chr5:1282739ENST0000031058111658_1975241133.0RegionNote=GQ motif
TgeneTERTchr14:57866601chr5:1282739ENST000003346021151_2305241070.0RegionNote=RNA-interacting domain 1
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115231_3245241070.0RegionNote=Linker
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115301_5385241070.0RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115325_5505241070.0RegionNote=RNA-interacting domain 2
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115376_5215241070.0RegionNote=QFP motif
TgeneTERTchr14:57866601chr5:1282739ENST00000334602115397_4175241070.0RegionNote=CP motif
TgeneTERTchr14:57866601chr5:1282739ENST0000033460211558_1975241070.0RegionNote=GQ motif
TgeneTERTchr14:57866601chr5:1282739ENST00000508104181_230524808.0RegionNote=RNA-interacting domain 1
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418231_324524808.0RegionNote=Linker
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418301_538524808.0RegionNote=Required for oligomerization
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418325_550524808.0RegionNote=RNA-interacting domain 2
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418376_521524808.0RegionNote=QFP motif
TgeneTERTchr14:57866601chr5:1282739ENST0000050810418397_417524808.0RegionNote=CP motif
TgeneTERTchr14:57866601chr5:1282739ENST000005081041858_197524808.0RegionNote=GQ motif


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Fusion Gene Sequence for NAA30-TERT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>56978_56978_1_NAA30-TERT_NAA30_chr14_57866601_ENST00000555166_TERT_chr5_1282739_ENST00000296820_length(transcript)=2540nt_BP=342nt
AGGCCCAGGAAACTTTACCCGGCCTAACAGCTGAGGCGCTTTACGGCGACGGCGGCTGAGTGAGAACCTTGGCGGCTGTGGAGGCTGCCG
CGGCTGCGAAGGAGGCGGCGGCGGTGGCGGAGGAAGAGGAGTGGCGGCAGCGGCGGCGGGGACCCGTGCGGGGCCATGGTAGGGGAGGAG
TGTGTAGGTGCCATCGTTTGCAAGTTGGATATGCACAAAAAGATGTTCCGCAGAGGTTATATAGCCATGTTAGCCGTGGATTCCAAATAC
AGGAGAAATGGCATTGGTACTAACTTGGTTAAGAAAGCTATATATGCCATGGTTGAGGGAGACTGTGATGAGGGGTTGGCTGTGTTCCGG
CCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCT
TTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGTTGCAAAGCATTGGAATCAGAC
AGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGAC
TCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGG
CCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGC
TGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGG
TGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCAAACCCCAGAACACGTACTGCG
TGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCCTACGTCCAGTGCCAGGGGATC
CCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGG
CTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTC
CCTGAGTATGGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGTAGAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAG
ATGCCGGCCCACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGACCCTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGG
ACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAG
TGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTACAAGATCCTCCTGCTGCAGGCGTACAGG
TTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCC
CTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAG
TGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACG
CAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGCCCTCAGACTTCAAGACCATCCTG
GACTGATGGCCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTGTCACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGG
CCCACACCCAGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGCCGAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGG
CTGAGGCCTGAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCGTCTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCC
CAGGGCCAGCTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAATAGTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCC
CTGCCCTCCTTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGACCCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTG
TGCCCTGTACACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCAAATTGGGGGGAGGTGCTGTGGGAGTAAAATACTGAAT

>56978_56978_1_NAA30-TERT_NAA30_chr14_57866601_ENST00000555166_TERT_chr5_1282739_ENST00000296820_length(amino acids)=328AA_BP=
MPWSRRPPMGTSARPSRATSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEY
GCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHS
LFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLC

--------------------------------------------------------------
>56978_56978_2_NAA30-TERT_NAA30_chr14_57866601_ENST00000556492_TERT_chr5_1282739_ENST00000296820_length(transcript)=3303nt_BP=1105nt
AAACTTTACCCGGCCTAACAGCTGAGGCGCTTTACGGCGACGGCGGCTGAGTGAGAACCTTGGCGGCTGTGGAGGCTGCCGCGGCTGCGA
AGGAGGCGGCGGCGGTGGCGGAGGAAGAGGAGTGGCGGCAGCGGCGGCGGGGACCCGTGCGGGGATGGCGGAGGTACCGCCTGGGCCTAG
CAGCCTCCTCCCACCACCAGCACCTCCGGCCCCGGCGGCGGTCGAGCCCCGCTGTCCCTTCCCGGCGGGGGCCGCCCTCGCCTGCTGCAG
CGAGGACGAGGAGGACGACGAAGAGCACGAAGGCGGCGGCAGCAGGAGCCCGGCGGGCGGAGAGTCGGCGACGGTGGCGGCCAAGGGGCA
TCCGTGCCTCCGCTGCCCTCAGCCGCCGCAGGAGCAGCAGCAGCTCAACGGATTGATTAGCCCCGAACTGCGGCACCTCCGGGCGGCCGC
CTCCCTCAAGAGCAAGGTCCTGAGCGTAGCAGAGGTGGCCGCGACCACAGCCACCCCTGACGGAGGCCCCAGAGCGACTGCAACAAAAGG
AGCCGGGGTACACTCGGGCGAGAGGCCCCCTCACTCCCTCTCTAGTAATGCAAGAACTGCGGTCCCCAGCCCGGTGGAGGCAGCGGCGGC
GAGCGATCCCGCGGCGGCCCGCAATGGACTGGCCGAGGGCACCGAGCAGGAGGAGGAGGAGGAAGACGAGCAGGTGCGGCTGCTGTCTTC
GTCCCTGACCGCCGACTGCAGCTTAAGAAGCCCTTCGGGCAGGGAGGTTGAGCCTGGGGAGGATCGGACGATACGATATGTCCGATATGA
ATCCGAGCTACAAATGCCCGATATCATGAGACTGATCACCAAAGATCTGTCCGAACCCTACTCCATTTATACCTATAGATATTTTATCCA
CAACTGGCCACAGCTGTGCTTCTTGGCCATGGTAGGGGAGGAGTGTGTAGGTGCCATCGTTTGCAAGTTGGATATGCACAAAAAGATGTT
CCGCAGAGGTTATATAGCCATGTTAGCCGTGGATTCCAAATACAGGAGAAATGGCATTGGTACTAACTTGGTTAAGAAAGCTATATATGC
CATGGTTGAGGGAGACTGTGATGAGGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCAC
TGGCTGATGAGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTAC
CGGAAGAGTGTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTC
AGGCAGCATCGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATG
GACTACGTCGTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAAC
TACGAGCGGGCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGT
GTGCGGGCCCAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACG
GAGGTCATCGCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGC
AAGGCCTTCAAGAGCCACGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGG
CGACATGGAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCT
CACCCACGCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTCCCTGAGTATGGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTT
CCCTGTAGAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAGATGCCGGCCCACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATAC
CCGGACCCTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGG
GAGGAACATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGT
GTGCACCAACATCTACAAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAA
GAACCCCACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGG
GGCCAAGGGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGT
CACCTACGTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGC
CGCAGCCAACCCGGCACTGCCCTCAGACTTCAAGACCATCCTGGACTGATGGCCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCA
GCCCTGTCACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGGCCCACACCCAGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTG
TTTGGCCGAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCTGAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACAC
CTGCCGTCTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCCCAGGGCCAGCTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACAT
AGGAATAGTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCCCTGCCCTCCTTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGA
GAAGGACCCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTGTGCCCTGTACACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGT

>56978_56978_2_NAA30-TERT_NAA30_chr14_57866601_ENST00000556492_TERT_chr5_1282739_ENST00000296820_length(amino acids)=376AA_BP=353
MSENLGGCGGCRGCEGGGGGGGGRGVAAAAAGTRAGMAEVPPGPSSLLPPPAPPAPAAVEPRCPFPAGAALACCSEDEEDDEEHEGGGSR
SPAGGESATVAAKGHPCLRCPQPPQEQQQLNGLISPELRHLRAAASLKSKVLSVAEVAATTATPDGGPRATATKGAGVHSGERPPHSLSS
NARTAVPSPVEAAAASDPAAARNGLAEGTEQEEEEEDEQVRLLSSSLTADCSLRSPSGREVEPGEDRTIRYVRYESELQMPDIMRLITKD
LSEPYSIYTYRYFIHNWPQLCFLAMVGEECVGAIVCKLDMHKKMFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVEGDCDEGLAVFRP

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Fusion Gene PPI Analysis for NAA30-TERT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAA30-TERT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAA30-TERT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource