|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:APP-NARG2 (FusionGDB2 ID:5699) |
Fusion Gene Summary for APP-NARG2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APP-NARG2 | Fusion gene ID: 5699 | Hgene | Tgene | Gene symbol | APP | NARG2 | Gene ID | 351 | 79664 |
| Gene name | amyloid beta precursor protein | interactor of little elongation complex ELL subunit 2 | |
| Synonyms | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 | BRCC1|NARG2 | |
| Cytomap | 21q21.3 | 15q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | amyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei | little elongation complex subunit 2NMDA receptor regulated 2NMDA receptor-regulated gene 2NMDA receptor-regulated protein 2breast cancer cell 1interactor of little elongator complex ELL subunit 2 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P05067 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000346798, ENST00000348990, ENST00000354192, ENST00000357903, ENST00000359726, ENST00000439274, ENST00000440126, ENST00000448388, ENST00000358918, ENST00000474136, | ENST00000558654, ENST00000561114, ENST00000261520, ENST00000439632, | |
| Fusion gene scores | * DoF score | 31 X 25 X 12=9300 | 2 X 2 X 2=8 |
| # samples | 33 | 2 | |
| ** MAII score | log2(33/9300*10)=-4.81669278663694 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: APP [Title/Abstract] AND NARG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | APP(27277335)-NARG2(60728426), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APP | GO:0001934 | positive regulation of protein phosphorylation | 11404397 |
| Hgene | APP | GO:0008285 | negative regulation of cell proliferation | 22944668 |
| Hgene | APP | GO:1905606 | regulation of presynapse assembly | 19726636 |
| Fusion gene breakpoints across APP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across NARG2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-EQ-A4SO | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
Top |
Fusion Gene ORF analysis for APP-NARG2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000346798 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000346798 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000348990 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000348990 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000354192 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000354192 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000357903 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000357903 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000359726 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000359726 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000439274 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000439274 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000440126 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000440126 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000448388 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| 5CDS-intron | ENST00000448388 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000346798 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000346798 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000348990 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000348990 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000354192 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000354192 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000357903 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000357903 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000359726 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000359726 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000439274 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000439274 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000440126 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000440126 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000448388 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| In-frame | ENST00000448388 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-3CDS | ENST00000358918 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-3CDS | ENST00000358918 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-3CDS | ENST00000474136 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-3CDS | ENST00000474136 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-intron | ENST00000358918 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-intron | ENST00000358918 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-intron | ENST00000474136 | ENST00000558654 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| intron-intron | ENST00000474136 | ENST00000561114 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000346798 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6546 | 1997 | 34 | 2520 | 828 |
| ENST00000346798 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6546 | 1997 | 34 | 2520 | 828 |
| ENST00000354192 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6246 | 1697 | 127 | 2220 | 697 |
| ENST00000354192 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6246 | 1697 | 127 | 2220 | 697 |
| ENST00000348990 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6434 | 1885 | 147 | 2408 | 753 |
| ENST00000348990 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6434 | 1885 | 147 | 2408 | 753 |
| ENST00000357903 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6622 | 2073 | 167 | 2596 | 809 |
| ENST00000357903 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6622 | 2073 | 167 | 2596 | 809 |
| ENST00000359726 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6544 | 1995 | 200 | 2518 | 772 |
| ENST00000359726 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6544 | 1995 | 200 | 2518 | 772 |
| ENST00000448388 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6374 | 1825 | 168 | 2348 | 726 |
| ENST00000448388 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6374 | 1825 | 168 | 2348 | 726 |
| ENST00000440126 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6706 | 2157 | 239 | 2680 | 813 |
| ENST00000440126 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6706 | 2157 | 239 | 2680 | 813 |
| ENST00000439274 | APP | chr21 | 27277335 | - | ENST00000439632 | NARG2 | chr15 | 60728426 | - | 6378 | 1829 | 34 | 2352 | 772 |
| ENST00000439274 | APP | chr21 | 27277335 | - | ENST00000261520 | NARG2 | chr15 | 60728426 | - | 6378 | 1829 | 34 | 2352 | 772 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000346798 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000324334 | 0.99967563 |
| ENST00000346798 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000324334 | 0.99967563 |
| ENST00000354192 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000294187 | 0.99970573 |
| ENST00000354192 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000294187 | 0.99970573 |
| ENST00000348990 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000461436 | 0.99953854 |
| ENST00000348990 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000461436 | 0.99953854 |
| ENST00000357903 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.00032766 | 0.9996723 |
| ENST00000357903 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.00032766 | 0.9996723 |
| ENST00000359726 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000574203 | 0.99942577 |
| ENST00000359726 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000574203 | 0.99942577 |
| ENST00000448388 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000531696 | 0.99946827 |
| ENST00000448388 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000531696 | 0.99946827 |
| ENST00000440126 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000373663 | 0.9996263 |
| ENST00000440126 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000373663 | 0.9996263 |
| ENST00000439274 | ENST00000439632 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000296481 | 0.99970347 |
| ENST00000439274 | ENST00000261520 | APP | chr21 | 27277335 | - | NARG2 | chr15 | 60728426 | - | 0.000296481 | 0.99970347 |
Top |
Fusion Genomic Features for APP-NARG2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for APP-NARG2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27277335/chr15:60728426) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APP | . |
| FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 230_260 | 654 | 771.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 274_280 | 654 | 771.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 230_260 | 579 | 696.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 274_280 | 579 | 696.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 230_260 | 523 | 640.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 274_280 | 523 | 640.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 230_260 | 635 | 752.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 274_280 | 635 | 752.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 230_260 | 598 | 715.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 274_280 | 598 | 715.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 230_260 | 630 | 747.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 274_280 | 630 | 747.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 28_189 | 654 | 771.0 | Domain | E1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 374_565 | 654 | 771.0 | Domain | E2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 28_189 | 579 | 696.0 | Domain | E1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 374_565 | 579 | 696.0 | Domain | E2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 28_189 | 523 | 640.0 | Domain | E1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 28_189 | 635 | 752.0 | Domain | E1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 374_565 | 635 | 752.0 | Domain | E2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 28_189 | 598 | 715.0 | Domain | E1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 374_565 | 598 | 715.0 | Domain | E2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 28_189 | 630 | 747.0 | Domain | E1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 374_565 | 630 | 747.0 | Domain | E2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 344_365 | 654 | 771.0 | Motif | OX-2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 344_365 | 579 | 696.0 | Motif | OX-2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 344_365 | 523 | 640.0 | Motif | OX-2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 344_365 | 635 | 752.0 | Motif | OX-2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 344_365 | 598 | 715.0 | Motif | OX-2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 344_365 | 630 | 747.0 | Motif | OX-2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 131_189 | 654 | 771.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 181_188 | 654 | 771.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 28_123 | 654 | 771.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 391_423 | 654 | 771.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 491_522 | 654 | 771.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 523_540 | 654 | 771.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 96_110 | 654 | 771.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 131_189 | 579 | 696.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 181_188 | 579 | 696.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 28_123 | 579 | 696.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 391_423 | 579 | 696.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 491_522 | 579 | 696.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 523_540 | 579 | 696.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 96_110 | 579 | 696.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 131_189 | 523 | 640.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 181_188 | 523 | 640.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 28_123 | 523 | 640.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 391_423 | 523 | 640.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 491_522 | 523 | 640.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 96_110 | 523 | 640.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 131_189 | 635 | 752.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 181_188 | 635 | 752.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 28_123 | 635 | 752.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 391_423 | 635 | 752.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 491_522 | 635 | 752.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 523_540 | 635 | 752.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 96_110 | 635 | 752.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 131_189 | 598 | 715.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 181_188 | 598 | 715.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 28_123 | 598 | 715.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 391_423 | 598 | 715.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 491_522 | 598 | 715.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 523_540 | 598 | 715.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 96_110 | 598 | 715.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 131_189 | 630 | 747.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 181_188 | 630 | 747.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 28_123 | 630 | 747.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 391_423 | 630 | 747.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 491_522 | 630 | 747.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 523_540 | 630 | 747.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 96_110 | 630 | 747.0 | Region | Heparin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 230_260 | 0 | 753.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 274_280 | 0 | 753.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 374_565 | 523 | 640.0 | Domain | E2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 28_189 | 0 | 753.0 | Domain | E1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 374_565 | 0 | 753.0 | Domain | E2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 724_734 | 654 | 771.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 724_734 | 579 | 696.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 724_734 | 523 | 640.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 724_734 | 635 | 752.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 344_365 | 0 | 753.0 | Motif | OX-2 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 724_734 | 0 | 753.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 724_734 | 598 | 715.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 724_734 | 630 | 747.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 523_540 | 523 | 640.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 131_189 | 0 | 753.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 181_188 | 0 | 753.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 28_123 | 0 | 753.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 391_423 | 0 | 753.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 491_522 | 0 | 753.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 523_540 | 0 | 753.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 96_110 | 0 | 753.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 18_701 | 654 | 771.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 723_770 | 654 | 771.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 18_701 | 579 | 696.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 723_770 | 579 | 696.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 18_701 | 523 | 640.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 723_770 | 523 | 640.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 18_701 | 635 | 752.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 723_770 | 635 | 752.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 18_701 | 0 | 753.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 723_770 | 0 | 753.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 18_701 | 598 | 715.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 723_770 | 598 | 715.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 18_701 | 630 | 747.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 723_770 | 630 | 747.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 702_722 | 654 | 771.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 702_722 | 579 | 696.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 702_722 | 523 | 640.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 702_722 | 635 | 752.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 702_722 | 0 | 753.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 702_722 | 598 | 715.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 702_722 | 630 | 747.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for APP-NARG2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5699_5699_1_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6546nt_BP=1997nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGC AGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGA GGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGA GGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATT CTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTT ACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCT CGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGT CATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGT GGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCG CCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCG CGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCA GGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCA GGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGG AAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCA GCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGG ACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCT TTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATC TCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTG CGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAG AATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAA TCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTG AGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAG AGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCT TTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTA AACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCC AGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGAC AGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCC AAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGT GGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTT TTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCG CTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCT CCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGC CGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCC AGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGAT GTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAG GCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGT GGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCG CACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTT ACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCT ATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATAC TTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGT ATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTT TGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTA CATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTT TAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTT GTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAG AAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCT GCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTT TAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAA AACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCA GATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCA TTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTT TTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGAT CTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAA AGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCA GGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGAT CAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGT GTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAA TGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCC ATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGT TTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTT TCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAA GCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAG GGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTT TCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTT >5699_5699_1_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=828AA_BP=654 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP ANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIY KASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCL -------------------------------------------------------------- >5699_5699_2_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6546nt_BP=1997nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGC AGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGA GGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGA GGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATT CTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTT ACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCT CGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGT CATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGT GGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCG CCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCG CGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCA GGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCA GGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGG AAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCA GCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGG ACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCT TTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATC TCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTG CGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAG AATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAA TCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTG AGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAG AGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCT TTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTA AACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCC AGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGAC AGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCC AAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGT GGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTT TTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCG CTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCT CCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGC CGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCC AGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGAT GTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAG GCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGT GGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCG CACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTT ACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCT ATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATAC TTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGT ATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTT TGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTA CATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTT TAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTT GTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAG AAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCT GCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTT TAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAA AACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCA GATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCA TTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTT TTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGAT CTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAA AGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCA GGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGAT CAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGT GTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAA TGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCC ATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGT TTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTT TCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAA GCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAG GGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTT TCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTT >5699_5699_2_APP-NARG2_APP_chr21_27277335_ENST00000346798_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=828AA_BP=654 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP ANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIY KASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCL -------------------------------------------------------------- >5699_5699_3_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6434nt_BP=1885nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGT GATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAG TCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAG CACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTG ATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTT CAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCT TTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCT GACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCAT ATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAAT TTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCA CTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCC AGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCG AAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAA AGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTA AATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAG CTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGA GGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAA TAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAA AAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAA ATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTC TGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAG ATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTC ATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTG CAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGG CACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGA CCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTC ATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACT TAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCA GGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGC TACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGT ATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTA TGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTAT TCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTT GTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCA TCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGC GAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGA ATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTT ACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTT TTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAG CAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCA CTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCA AGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGA GTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTT TCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATAC AGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCT AGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGA GATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCA GCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTG CTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGC TCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGC AATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTG GTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAG AGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAA CCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGT CTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCT TGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACT TTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAG TAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTT >5699_5699_3_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=753AA_BP=579 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGS YLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTR -------------------------------------------------------------- >5699_5699_4_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6434nt_BP=1885nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGT GATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAG TCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAG CACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTG ATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTT CAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCT TTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCT GACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCAT ATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAAT TTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCA CTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCC AGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCG AAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAA AGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTA AATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAG CTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGA GGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAA TAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAA AAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAA ATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTC TGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAG ATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTC ATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTG CAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGG CACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGA CCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTC ATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACT TAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCA GGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGC TACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGT ATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTA TGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTAT TCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTT GTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCA TCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGC GAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGA ATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTT ACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTT TTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAG CAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCA CTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCA AGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGA GTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTT TCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATAC AGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCT AGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGA GATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCA GCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTG CTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGC TCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGC AATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTG GTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAG AGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAA CCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGT CTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCT TGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACT TTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAG TAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTT >5699_5699_4_APP-NARG2_APP_chr21_27277335_ENST00000348990_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=753AA_BP=579 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQ IRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSL DDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGS YLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTR -------------------------------------------------------------- >5699_5699_5_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6246nt_BP=1697nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAA AGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGT AGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGA AGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGC CCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCA AGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGA GAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGC TCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCT AAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGA GCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGA GCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGA AACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGT GCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGC ATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAA CATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGAT TTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTC AGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACT GGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTG CTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAA AAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTG CCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTG ATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAA TAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAA TGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAA TGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGT CAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCT ATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCC AGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCA TGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACC ACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGA TCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATAC TGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAAC TACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGG AGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAA AGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGT GTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTC ATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGG CCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATT TTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCA TTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAG GGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTC TTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATA AAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATA CATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGT AATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTC CATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTG ATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACT ATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGAT TTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTG TCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAG ACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAAC TTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGA AAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACA TTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTG GCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCC AGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAG AGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAA GAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTG CTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATG AAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGA GAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTT TCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTT TGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTTCTTGTTGA >5699_5699_5_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=697AA_BP=523 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMI SEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEIT SEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLL -------------------------------------------------------------- >5699_5699_6_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6246nt_BP=1697nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAA AGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGT AGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGA AGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGC CCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCA AGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGA GAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGC TCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCT AAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGA GCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGA GCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGA AACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGT GCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGC ATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAA CATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGAT TTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTC AGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACT GGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTG CTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAA AAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTG CCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTG ATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAA TAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAA TGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAA TGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGT CAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCT ATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCC AGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCA TGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACC ACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGA TCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATAC TGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAAC TACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGG AGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAA AGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGT GTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTC ATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGG CCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATT TTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCA TTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAG GGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTC TTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATA AAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATA CATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGT AATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTC CATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTG ATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACT ATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGAT TTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTG TCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAG ACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAAC TTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGA AAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACA TTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTG GCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCC AGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAG AGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAA GAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTG CTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATG AAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGA GAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTT TCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTT TGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGTTTCTTGTTGA >5699_5699_6_APP-NARG2_APP_chr21_27277335_ENST00000354192_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=697AA_BP=523 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVF NMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMI SEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEIT SEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLL -------------------------------------------------------------- >5699_5699_7_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6622nt_BP=2073nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATG ACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCA CCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCT CCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAG AGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGG ACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATG AGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCA TGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTT TTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGAC CAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGA TTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAG ATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTG TACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTT TTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGG AAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATG GAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCC TGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAG TTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAA ATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACT GACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACT CCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTC CCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTT GATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAG TCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGG CTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGG ACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAA ACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTT TTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAA TTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACT TGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTA GTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCA GCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTC AGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGA ATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTAC CAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCA TTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCAT TTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACC AGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATAT TACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGC CTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAAT ATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGA TGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAG GGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCA GTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATT TATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACA CCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGAT CACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGG TTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAA ACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAA ACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTG AAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGA AAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTT TGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGT GTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATT GGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAA GTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGC TCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAA AGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAG GTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTA >5699_5699_7_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=809AA_BP=635 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR RLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRG LTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHC -------------------------------------------------------------- >5699_5699_8_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6622nt_BP=2073nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATG ACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCA CCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCT CCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAG AGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGG ACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACC TCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATG AGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCA TGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTT TTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGAC CAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGA TTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAG ATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTG TACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTT TTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGG AAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATG GAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCC TGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAG TTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAA ATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACT GACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACT CCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTC CCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTT GATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAG TCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGG CTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGG ACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAA ACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTT TTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAA TTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACT TGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTA GTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCA GCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTC AGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGA ATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTAC CAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCA TTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCAT TTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACC AGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATAT TACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGC CTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAAT ATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGA TGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAG GGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCA GTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATT TATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACA CCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGAT CACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGG TTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAA ACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAA ACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTG AAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGA AAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTT TGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGT GTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATT GGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAA GTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGC TCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAA AGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAG GTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTA >5699_5699_8_APP-NARG2_APP_chr21_27277335_ENST00000357903_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=809AA_BP=635 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR RLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQ DEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRG LTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHC -------------------------------------------------------------- >5699_5699_9_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6544nt_BP=1995nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCG CAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGG TTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGG ATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAA ACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGC CGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGAC TGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTT CAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTC ATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCG GCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAA TACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATC CAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAG GACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAG GAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTT TCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAA CCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAG TCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAG TTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAA AAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGG TATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTT CCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCT CTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCC CGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCG GGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAG CATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGT TGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGC GGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGG GGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCA CCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTAC ACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTAT TCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTT ATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTAT CTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTG GTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACA TTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTA ATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGT GCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAA GTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGC AGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTA AATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAA CAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGA TCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATT AAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTT TTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCT TGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAG AAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGG ATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCA GATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGT TGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATG ACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCAT TGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTT GTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTC TGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGC CCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGG GAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTC TATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGA >5699_5699_9_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=772AA_BP=598 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP -------------------------------------------------------------- >5699_5699_10_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6544nt_BP=1995nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCG CAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGG TTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGG ATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAA ACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGC CGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGAC TGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTT CAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTC ATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCG GCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAA TACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATC CAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAG GACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAG GAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTT TCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAA CCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAG TCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAG TTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAA AAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGG TATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTT CCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCT CTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCC CGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCG GGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAG CATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGT TGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGC GGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGG GGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCA CCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTAC ACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTAT TCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTT ATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTAT CTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTG GTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACA TTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTA ATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGT GCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAA GTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGC AGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTA AATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAA CAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGA TCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATT AAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTT TTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCT TGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAG AAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGG ATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCA GATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGT TGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATG ACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCAT TGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTT GTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTC TGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGC CCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGG GAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTC TATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGA >5699_5699_10_APP-NARG2_APP_chr21_27277335_ENST00000359726_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=772AA_BP=598 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP -------------------------------------------------------------- >5699_5699_11_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6378nt_BP=1829nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGT AGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGA GGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGA GGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAA GTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCAT GTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGT TGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAG AATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTT CCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAA GAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCA GATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGC CGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAG GATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCT GGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGC TGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATT AAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTC CTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTA TAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATAT CCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACG CAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAG AAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAA TCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATG GAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAAT ATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTT AGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTG ACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCC ATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAG AAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGA GATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGA GATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTC CTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGT TACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCA CCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCA TAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTT CGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTA GCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGT GAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATC TTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGA AATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAAC AGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTAT TAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATC CCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTT ATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAA AGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGT AGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAAT TTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAG GAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTT TTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACA CACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGC CTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTG TTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGT ATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTC ATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAA GGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGA GAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATT AACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATG TTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGA AAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGA TGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTT TGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACAT TATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTA GTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTAT GAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGAT GTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAAC >5699_5699_11_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=772AA_BP=598 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP -------------------------------------------------------------- >5699_5699_12_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6378nt_BP=1829nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGT AGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGA GGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGA GGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAA GTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCAT GTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGT TGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAG AATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTT CCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAA GAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCA GATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGC CGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAG GATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCT GGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGC TGCCGACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATT AAAAGAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTC CTACTTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTA TAAAACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATAT CCATCATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACG CAGCCACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAG AAAAATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAA TCAGTAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATG GAATGGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAAT ATTTTTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTT AGTTATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTG ACCCATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCC ATTACAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAG AAAAAATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGA GATAGGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGA GATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTC CTGCCTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGT TACCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCA CCGTGCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCA TAATCAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTT CGCAAGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTA GCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGT GAGTTGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATC TTTAGAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGA AATTTTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAAC AGTTGAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTAT TAGTAAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATC CCAGAAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTT ATTTTTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAA AGACTTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGT AGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAAT TTATAAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAG GAGTTTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTT TTTTTTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACA CACCTCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGC CTTGTTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTG TTTTGTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGT ATCAAAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTC ATCTAACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAA GGTCTTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGA GAGAAAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATT AACTGACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATG TTGGGAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGA AAAAAAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGA TGGTGTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTT TGGATTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACAT TATCTCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTA GTAAGTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTAT GAACAGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGAT GTTAAGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAAC >5699_5699_12_APP-NARG2_APP_chr21_27277335_ENST00000439274_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=772AA_BP=598 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQ HTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISN LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPP -------------------------------------------------------------- >5699_5699_13_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6706nt_BP=2157nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGG ACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCA CCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCT GGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACT GCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGC TTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCAT CTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGG CTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGC ATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCA ATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTT CACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTT CCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCAC CGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCA AAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAAC TAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGT AGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAG GAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTA AATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCA AAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTA AAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCC TCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGAC AGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTG TCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAG TGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACA GGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCT GACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCC TCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGA CTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTC CAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCA GCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGA GTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAAT TATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCT ATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTT TTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCT CATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCA GCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATG GAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTT TTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTT TTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTT AGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGC CACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAG CAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGT GAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTG TTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAAT ACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATT CTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCT GAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAG CAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTG TGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGG GCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATG GCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGT TGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTT AGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTAT AACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAG GTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACC CTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAA CTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATAT AGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGT >5699_5699_13_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=813AA_BP=639 MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEAT ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAV DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAML NDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPA ADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLY KTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKR -------------------------------------------------------------- >5699_5699_14_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6706nt_BP=2157nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGG ACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCA CCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCT GGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACT GCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGAC AGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTG TGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGC TTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCAT CTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGG CTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGGC ATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAAGAAAAGCTTTCAGCACTCAAGATTTCCA ATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTACTTGTTATCTCATGCAGCAGAAGATTCTT CACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAAACACATTGCGGCCTTCCTGGTGTACCTT CCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCATCATGGAAGAATACCTTGTACTTTTCCAC CGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGCCACAGGAATCCAGTTTCCATGGAAACCA AAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAAATAACTTGAGGACTGTACCATGGAAAAC TAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAGTAGGCAAGAGGAACATTTTTCCTGTAGT AGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAATGGTATGCTTTTCACCCTTGAAGTTTGAG GAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTTTTACATTAAACCTTTTCTAAAAATTGTA AATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTTATATTGCCAGTCTGTTGCGACTGACTCA AAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCCATTTTGACAGTTTTTATATACTCCTTTA AAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTACAGAAGCCAAAAATAAAAACTCCCTGCC TCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAAAATTTGGTGGTATAACATGTTTGATGAC AGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATAGGTATGTTTTCCAGAAAAAAAGTCAGTG TCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAG TGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGCCTCATCCTCCCGAGTAGCTGGGACTACA GGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACCATGTTGGCCGGGCTGGTCTCAAACTCCT GACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGTGCCTGGCCAGCATAAGCTATTTTTATCC TCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAATCAACTGATGTTGCTGTAGCAAATTTGGA CTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCAAGGCCGAGGCGGGAGAATCACTTGAGTC CAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCGGGTGTGGTGGGGTGTGCCTGTAGTCCCA GCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGTTGTGATCGCACCACAGAACTCAGCTTGA GTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTAGAACCCTTACACTAAAATTTTCAGAAAT TATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATTTTTTAGCTATTCTGTGTAAAGAATAGCT ATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTTGAAAATACTTATATTCAACTACCAAGTT TTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGTAAAATTGTATCTTGATAAATCATTTCCT CATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAGAAATGTTTTGGTTGTGAATCATTTGCCA GCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTTTTAATGTACATTTGTGTGCACCAGAATG GAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGACTTGCCTTTTAATTTTTAAATATTACTTT TTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTTTTTTGCTTGTGCTTAGTGAAGCCTCCTT TTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTATAAGCCAAGAAGTAACTGACAATATGTTT AGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGTTTGAGGCTGCAGTGAGCTATGATGGTGC CACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTTTTTTTTTTTAAATCAGACTTAGGGCTAG CAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACCTCTTTGAAAACAGTTTAATTCAGTAAGT GAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTGTTTTTTCAGATCTCACCATATTTATTTG TTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTTGTTCACCATTAAGTAATAAACACCTAAT ACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCAAAGATTTTTTTTTTCAGGAGATCACATT CTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCTAACCAGATCTTGGTAGTTAAGGTTTTCT GAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTCTTCCACAAAGAAACTAAGTGAAACTAAG CAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGAAAACTGCAGGATAGGGACAGAAACACTG TGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACTGACATGATCAGATATGTATTTGAAAAGG GCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGGGAGCCTGTGTTGTAGTAACTGAAAAATG GCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAAAAAAAAAATGACAACTCAGTTTTGTTGT TGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGTGTTAACCCATTGAGAAAATAGTGTGGTT AGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGATTCTAGGTTTGTGTGCTATATTGGTTAT AACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATCTCACAGTTTCTGTAAGTCAAAAGTCCAG GTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAAGTCGCTAAGCCCACACTTAAGCTCCACC CTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAACAGGTTTAGGGGAGGGAGAGGAAAGAAAA CTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTAAGACGTTTTCTATGCATTATAGGTATAT AGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTAACGTATTTGATATTAAGATTTATTGAGT >5699_5699_14_APP-NARG2_APP_chr21_27277335_ENST00000440126_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=813AA_BP=639 MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEAT ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAV DKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAML NDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVA EEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPA ADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLY KTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKR -------------------------------------------------------------- >5699_5699_15_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000261520_length(transcript)=6374nt_BP=1825nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAA GCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGC ATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGAC AAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATG TCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAG GAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAAT GACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAG TATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATC CGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAG GAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATC AGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGAC GATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCC GACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAA GAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTAC TTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAA ACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCAT CATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGC CACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAA ATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAG TAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAAT GGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTT TTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTT ATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCC ATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTA CAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAA AATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATA GGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATG GAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGC CTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACC ATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGT GCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAAT CAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCA AGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCG GGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGT TGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTA GAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATT TTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTT GAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGT AAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAG AAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTT TTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGAC TTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTT TTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTAT AAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGT TTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTT TTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACC TCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTG TTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTT GTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCA AAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCT AACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTC TTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGA AAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACT GACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGG GAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAA AAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGT GTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGA TTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATC TCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAA GTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAAC AGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTA AGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTA >5699_5699_15_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000261520_length(amino acids)=726AA_BP=552 MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD VWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTP DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVE AMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDA RPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAY NLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAP -------------------------------------------------------------- >5699_5699_16_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000439632_length(transcript)=6374nt_BP=1825nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAA GCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGC ATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGAC AAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATG TCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAG GAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAAT GACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAG TATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATC CGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAG GAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATC AGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGAC GATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCC GACCGAGGACTGACCACTCGACCAGGGCATATCGATGCATTTACTTCAAAACTTTTTCTACTGGAAGAAATTACCTCAGAAGAATTAAAA GAAAAGCTTTCAGCACTCAAGATTTCCAATTTATTTAACATCCTCCAACACATTCTAAAGAAACTAAGTAGCTTGCAGGAGGGTTCCTAC TTGTTATCTCATGCAGCAGAAGATTCTTCACTCCTGATTTATAAGGCCTCTGATGGAAAAGTTACTAGGACAGCATACAATTTGTATAAA ACACATTGCGGCCTTCCTGGTGTACCTTCCAGTCTCTCAGTTCCCTGGGTCCCATTAGATCCCAGCCTGTTATTACCATATCATATCCAT CATGGAAGAATACCTTGTACTTTTCCACCGAAATCACTGGATACCACAACACAACAAAAGATTGGTGGAACGAGAATGCCTACACGCAGC CACAGGAATCCAGTTTCCATGGAAACCAAAAGCAGTTGCTTGCCTGCTCAGCAAGTTGAAACTGAAGGAGTGGCTCCACATAAAAGAAAA ATAACTTGAGGACTGTACCATGGAAAACTAAATTTAAAAAAACAGTTATAACAGTGTTTAATTTAGATAAGTTTGAGGGAAAATAATCAG TAGGCAAGAGGAACATTTTTCCTGTAGTAGCTAGAGTGCCTTGAAAAAATGTGTTGGCTATGTGAAGGAATATTTCAACTAAAATGGAAT GGTATGCTTTTCACCCTTGAAGTTTGAGGAGGATCTTGATATGTTTTAACATTATCATGGCAGGGAAATATATAAAGAAGAAAAATATTT TTACATTAAACCTTTTCTAAAAATTGTAAATAGAAAAATAATTTGGTTTTTTATCAAGAACAACACTTATCGTTATGTATTGTGTTAGTT ATATTGCCAGTCTGTTGCGACTGACTCAAAAAGTTAAATGTTGCCACTGCTGAAGATGATTATGAGCATCGCAAACTTTGTTTCTGACCC ATTTTGACAGTTTTTATATACTCCTTTAAAATGATGAATGTTACAGGTTAATAAAGTTAATACCTTTAAAAACTTGGTGAAATTCCATTA CAGAAGCCAAAAATAAAAACTCCCTGCCTCTGAAAAGTCAGATTACTGACTTCTTGTTTGGCAACCATCAGTTTGTTTAATAAAAGAAAA AATTTGGTGGTATAACATGTTTGATGACAGATGCCTCTATCTCTAGATTCAAGCTGAGTGTTGAAATACACTGCTGAAAGCAAAGAGATA GGTATGTTTTCCAGAAAAAAAGTCAGTGTCATTGCTCCAGATGACAAGGTTAATGTGGTAAAGCATAAGCTTTTTTTTTTTTTTGAGATG GAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACCACAACATCCACCTCCTGGATTAAAGCGATTCTCCTGC CTCATCCTCCCGAGTAGCTGGGACTACAGGCACCTACCACCAGGCTTGGCTAATTTTTTTTTGTATTTTTAGTAGAGACAGGGTGTTACC ATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGTAAGCCACCGT GCCTGGCCAGCATAAGCTATTTTTATCCTCATCTATACTGATTGATTTAAATTTTCCGGGCCTGCAGATGAATTTGGAAAAGGGCATAAT CAACTGATGTTGCTGTAGCAAATTTGGACTTAAGAAACTACAGACAGGGCCGGGCGTGGTGGCTCACACCTGTAATTCCAGCACTTCGCA AGGCCGAGGCGGGAGAATCACTTGAGTCCAGGGGTTGGAGACCAGTCTGGGCAACACAGACCTCATCTCTACAAATAAAAAAGTTAGCCG GGTGTGGTGGGGTGTGCCTGTAGTCCCAGCTACTCAAAAGGCTGAGGCAGAAGAATTGCTTGAGCCCAAGAAGTCAAGGCTACAGTGAGT TGTGATCGCACCACAGAACTCAGCTTGAGTATCAGAGTGTGACCCTGTCTCAAAGAAAAAAAAAAACAGGACAGGCTTGTTTAATCTTTA GAACCCTTACACTAAAATTTTCAGAAATTATGTATGTCATTTGTAAAATATAAGTTTTGTAATCCTAGATAATTGCTTCACATTGAAATT TTTTAGCTATTCTGTGTAAAGAATAGCTATTCTTTTGGCCTAATTTCTGAGAAATTAGACCGAAAAATCTCCTCAAGTATTGTAACAGTT GAAAATACTTATATTCAACTACCAAGTTTTGTTTCATTTTGATTTTTTGTTATAAAACATTTTTAAGTTATTTGAGAAGTAATTATTAGT AAAATTGTATCTTGATAAATCATTTCCTCATCCTGCCATTCCCTTTTATAAAACACTGAGTTTTTTTATTCCTTAAGTCACATATCCCAG AAATGTTTTGGTTGTGAATCATTTGCCAGCGAGCCAAGGGAGAGGCAGGGATTCCCTTGAAATGTACTCTTACACTTTTTTATTTTATTT TTAATGTACATTTGTGTGCACCAGAATGGAATGTGCTCTTTTTAAAGAGCTGGACAGTGGTTGCTTCAGACTTCTGAATACCAGAAAGAC TTGCCTTTTAATTTTTAAATATTACTTTTTACATCATAAAATGTGTTATCTTATCCATGTATTTGAATAACATCATATATAAAGGTAGTT TTTTGCTTGTGCTTAGTGAAGCCTCCTTTTTTAACATACATTTGATATGCTTTATGTTCTTTTTCTTGATTTTTAGTACTGAGAATTTAT AAGCCAAGAAGTAACTGACAATATGTTTAGCAGGATGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCGCTTGAGTCTAGGAGT TTGAGGCTGCAGTGAGCTATGATGGTGCCACTGCACTCCATCCTGGGTGAGAGATCAAGACCCTATCTCAAAAAATGAGCAAGTTTTTTT TTTTTTTTTAAATCAGACTTAGGGCTAGCAAGGATGTGATCACCCTGGCCCATTTATACCTCAGCAGTGAAGGTGTAATTTATACACACC TCTTTGAAAACAGTTTAATTCAGTAAGTGAGTGCAACTATGTGCCATGCACTCCAAAGTAGGTCCCCACAGTTATTCTCTCATAGCCTTG TTTTTTCAGATCTCACCATATTTATTTGTTTCTTTGATTTTCTTTTCTTATAGATTACAAGCTCTGCAAGGACAGGGGCATATTTGTTTT GTTCACCATTAAGTAATAAACACCTAATACAGTGCCTGTCATGTAGTTGCTTAGCAGATATTAGTTAGATGCATGAATGTGTAGGTATCA AAGATTTTTTTTTTCAGGAGATCACATTCTAGTGGAAGACACTATACTGCTTTATGTGATAAGTGCTTTGATAAAGTAAGCAAGTCATCT AACCAGATCTTGGTAGTTAAGGTTTTCTGAGATAGAACTTGAGCTGAGTCTTTTAAAAATAGTAGGATTTATAAGGGAAAATTAAAGGTC TTCCACAAAGAAACTAAGTGAAACTAAGCAGCCTATGAAAAGGTGAAAGTTGGAGAGATTATAGGCTATGAACATGGGAGATGAGAGAGA AAACTGCAGGATAGGGACAGAAACACTGTGCTAAGACATTTGAACTTTGTCCTGTGCAATGTGGGAACCAGTAGTGAAGGTTAATTAACT GACATGATCAGATATGTATTTGAAAAGGGCTCTTGTTGGCATTAGTCTAGAGAATGCGATGGAGCTGGGAAGCGAAAGAAGAAATGTTGG GAGCCTGTGTTGTAGTAACTGAAAAATGGCAATGGCCCAGAATTAAAGCAGCAAGAATAGGAGTGGGCTCAAGTGATGTATAAGGAAAAA AAAAAAAATGACAACTCAGTTTTGTTGTTGGTAAGGAGAGTAAAGTATGGCTTCTGGGTTTCTCATTTGAGATACTGAGTAAATGATGGT GTTAACCCATTGAGAAAATAGTGTGGTTAGAGTGGGAAGAAAGTTAATTTAAAATGTTCATTTTTTTTTTTAGTCATTTCTACTTTTGGA TTCTAGGTTTGTGTGCTATATTGGTTATAACCAATTTGCTGAATAATAAATTATCCCAAAACTTAGCTACTTAAAACAACAAACATTATC TCACAGTTTCTGTAAGTCAAAAGTCCAGGTCTCTCATGAAGTTGCAGTCAGGCTCTTGGCTAGGGCTGCAGTCATCTGAAGGATTAGTAA GTCGCTAAGCCCACACTTAAGCTCCACCCTTGAAGGGAGAAGTTTGGAAAGAATTTGTGAACATATTTTTAAATCACATATGCTATGAAC AGGTTTAGGGGAGGGAGAGGAAAGAAAACTTTAACTTTTCATTAGCATACTGCATCTGTAGTTCCTAATGGGCATGTTGTAAAGATGTTA AGACGTTTTCTATGCATTATAGGTATATAGTAGTATTTTGTTTTGTTCTGTTTTTTTGTTTGGTATGTAGTAGTTTTTAATCAAACCTTA >5699_5699_16_APP-NARG2_APP_chr21_27277335_ENST00000448388_NARG2_chr15_60728426_ENST00000439632_length(amino acids)=726AA_BP=552 MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD VWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTP DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVE AMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDA RPAADRGLTTRPGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAY NLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAP -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for APP-NARG2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 732_751 | 654.3333333333334 | 771.0 | G(o)-alpha |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 732_751 | 579.3333333333334 | 696.0 | G(o)-alpha |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 732_751 | 523.3333333333334 | 640.0 | G(o)-alpha |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 732_751 | 635.3333333333334 | 752.0 | G(o)-alpha |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 732_751 | 0 | 753.0 | G(o)-alpha |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 732_751 | 598.3333333333334 | 715.0 | G(o)-alpha |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 732_751 | 630.3333333333334 | 747.0 | G(o)-alpha |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000346798 | - | 15 | 18 | 695_722 | 654.3333333333334 | 771.0 | PSEN1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000348990 | - | 13 | 16 | 695_722 | 579.3333333333334 | 696.0 | PSEN1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000354192 | - | 12 | 15 | 695_722 | 523.3333333333334 | 640.0 | PSEN1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000357903 | - | 14 | 17 | 695_722 | 635.3333333333334 | 752.0 | PSEN1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000358918 | - | 1 | 17 | 695_722 | 0 | 753.0 | PSEN1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000359726 | - | 14 | 17 | 695_722 | 598.3333333333334 | 715.0 | PSEN1 |
| Hgene | APP | chr21:27277335 | chr15:60728426 | ENST00000440126 | - | 14 | 17 | 695_722 | 630.3333333333334 | 747.0 | PSEN1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for APP-NARG2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for APP-NARG2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies