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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AAK1-FNTA (FusionGDB2 ID:57)

Fusion Gene Summary for AAK1-FNTA

check button Fusion gene summary
Fusion gene informationFusion gene name: AAK1-FNTA
Fusion gene ID: 57
HgeneTgene
Gene symbol

AAK1

FNTA

Gene ID

112268437

2339

Gene nameuncharacterized protein FLJ45252farnesyltransferase, CAAX box, alpha
SynonymsAAK1FPTA|PGGT1A|PTAR2
Cytomap

-

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein FLJ45252alternative protein AAK1protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaFTase-alphaGGTase-I-alphafarnesyl-protein transferase alpha-subunitprotein prenyltransferase alpha subunit repeat containing 2ras proteins prenyltransferase subunit alphatype
Modification date2020030320200313
UniProtAcc

Q2M2I8

P49354

Ensembl transtripts involved in fusion geneENST00000406297, ENST00000409085, 
ENST00000409068, ENST00000470281, 
ENST00000524546, ENST00000529687, 
ENST00000342116, ENST00000302279, 
Fusion gene scores* DoF score19 X 13 X 11=271710 X 11 X 7=770
# samples 2214
** MAII scorelog2(22/2717*10)=-3.62643913669732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AAK1 [Title/Abstract] AND FNTA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAAK1(69732700)-FNTA(42919243), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFNTA

GO:0018343

protein farnesylation

16893176|19228685

TgeneFNTA

GO:0018344

protein geranylgeranylation

16893176

TgeneFNTA

GO:0090044

positive regulation of tubulin deacetylation

19228685

TgeneFNTA

GO:0090045

positive regulation of deacetylase activity

19228685


check buttonFusion gene breakpoints across AAK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FNTA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NQAAK1chr2

69732700

-FNTAchr8

42919243

+


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Fusion Gene ORF analysis for AAK1-FNTA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000406297ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-3UTRENST00000409085ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-5UTRENST00000406297ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-5UTRENST00000409085ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-intronENST00000406297ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+
5CDS-intronENST00000409085ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+
In-frameENST00000406297ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
In-frameENST00000409085ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3CDSENST00000409068ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3CDSENST00000470281ENST00000302279AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3UTRENST00000409068ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-3UTRENST00000470281ENST00000524546AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-5UTRENST00000409068ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-5UTRENST00000470281ENST00000529687AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-intronENST00000409068ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+
intron-intronENST00000470281ENST00000342116AAK1chr2

69732700

-FNTAchr8

42919243

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409085AAK1chr269732700-ENST00000302279FNTAchr842919243+4006264627834991073
ENST00000406297AAK1chr269732700-ENST00000302279FNTAchr842919243+4006264627834991073

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409085ENST00000302279AAK1chr269732700-FNTAchr842919243+0.0041931570.9958068
ENST00000406297ENST00000302279AAK1chr269732700-FNTAchr842919243+0.0041931570.9958068

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Fusion Genomic Features for AAK1-FNTA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AAK1chr269732700-FNTAchr842919243+1.75E-081
AAK1chr269732700-FNTAchr842919243+1.75E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AAK1-FNTA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:69732700/chr8:42919243)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AAK1

Q2M2I8

FNTA

P49354

FUNCTION: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869, PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}.FUNCTION: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-161812_42756864.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-1618397_614756864.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-1618658_663756864.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-162212_42756962.0Compositional biasNote=Gly-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-1622397_614756962.0Compositional biasNote=Gln-rich
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-1622658_663756962.0Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-161846_315756864.0DomainProtein kinase
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-162246_315756962.0DomainProtein kinase
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-161852_60756864.0Nucleotide bindingATP
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-162252_60756962.0Nucleotide bindingATP
TgeneFNTAchr2:69732700chr8:42919243ENST000003421160722_310313.0Compositional biasNote=Pro-rich
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919112_14695380.0RepeatNote=PFTA 1
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919147_18095380.0RepeatNote=PFTA 2
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919181_21595380.0RepeatNote=PFTA 3
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919216_24995380.0RepeatNote=PFTA 4
TgeneFNTAchr2:69732700chr8:42919243ENST0000030227919255_28995380.0RepeatNote=PFTA 5
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607112_1460313.0RepeatNote=PFTA 1
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607147_1800313.0RepeatNote=PFTA 2
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607181_2150313.0RepeatNote=PFTA 3
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607216_2490313.0RepeatNote=PFTA 4
TgeneFNTAchr2:69732700chr8:42919243ENST0000034211607255_2890313.0RepeatNote=PFTA 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69732700chr8:42919243ENST00000406297-1618823_960756864.0RegionClathrin-binding domain (CBD)
HgeneAAK1chr2:69732700chr8:42919243ENST00000409085-1622823_960756962.0RegionClathrin-binding domain (CBD)
TgeneFNTAchr2:69732700chr8:42919243ENST000003022791922_3195380.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for AAK1-FNTA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57_57_1_AAK1-FNTA_AAK1_chr2_69732700_ENST00000406297_FNTA_chr8_42919243_ENST00000302279_length(transcript)=4006nt_BP=2646nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA
GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG
GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC
GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC
CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA
GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA
GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG
AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC
AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG
ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC
AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG
TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA
CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC
AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC
CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC
AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC
AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG
CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC
CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC
TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA
ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG
ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG
ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGTTAGAGATGTTTATGATTACTTCCGAGCTGTCCTGCAGCGTGATGAAAGAAGTG
AACGAGCTTTTAAGCTAACCCGGGATGCTATTGAGTTAAATGCAGCCAATTATACAGTGTGGCATTTCCGGAGAGTTCTTTTGAAGTCAC
TTCAGAAGGATCTACATGAGGAAATGAACTACATCACTGCAATAATTGAGGAGCAGCCCAAAAACTATCAAGTTTGGCATCATAGGCGAG
TATTAGTGGAATGGCTAAGAGATCCATCTCAGGAGCTTGAATTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTATCATGCCTGGC
AGCATCGACAATGGGTTATTCAGGAATTTAAACTTTGGGATAATGAGCTGCAGTATGTGGACCAACTTCTGAAAGAGGATGTGAGAAATA
ACTCTGTCTGGAACCAAAGATACTTCGTTATTTCTAACACCACTGGCTACAATGATCGTGCTGTATTGGAGAGAGAAGTCCAATACACTC
TGGAAATGATTAAACTAGTACCACATAATGAAAGTGCATGGAACTATTTGAAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATATCCTA
ATCTGTTAAATCAATTACTTGATTTACAACCAAGTCATAGTTCCCCCTACCTAATTGCCTTTCTTGTGGATATCTATGAAGACATGCTAG
AAAATCAGTGTGACAATAAGGAAGACATTCTTAATAAAGCATTAGAGTTATGTGAAATCCTAGCTAAAGAAAAGGACACTATAAGAAAGG
AATATTGGAGATACATTGGAAGATCCCTTCAAAGCAAACACAGCACAGAAAATGACTCACCAACAAATGTACAGCAATAACACCATCCAG
AAGAACTTGATGGAATGCTTTTATTTTTTATTAAGGGACCCTGCAGGAGTTTCACACGAGAGTGGTCCTTCCCTTTGCCTGTGGTGTAAA
AGTGCATCACACAGGTATTGCTTTTTAACAAGAACTGATGCTCCTTGGGTGCTGCTGCTACTCAGACTAGCTCTAAGTAATGTGATTCTT
CTAAAGCAAAGTCATTGGATGGGAGGAGGAAGAAAAAGTCCCATAAAGGAACTTTTGTAGTCTTATCAACATATAATCTAATCCCTTAGC
ATCAGCTCCTCCCTCAGTGGTACATGCGTCAAGATTTGTAGCAGTAATAACTGCAGGTCACTTGTATGTAATGGATGTGAGGTAGCCGAA
GTTTGGTTCAGTAAGCAGGGAATACAGTCGTTCCATCAGAGCTGGTCTGCACACTCACATTATCTTGCTATCACTGTAACCAACTAATGC

>57_57_1_AAK1-FNTA_AAK1_chr2_69732700_ENST00000406297_FNTA_chr8_42919243_ENST00000302279_length(amino acids)=1073AA_BP=789
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGF
AIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFT
ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
IITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNS
PIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ
PKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT
QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPV
RQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVY
NPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTVRDVYDYFRAVLQRDERSERA
FKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHR
QWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLL

--------------------------------------------------------------
>57_57_2_AAK1-FNTA_AAK1_chr2_69732700_ENST00000409085_FNTA_chr8_42919243_ENST00000302279_length(transcript)=4006nt_BP=2646nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA
GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG
GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC
GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC
CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA
GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA
GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG
AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC
AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG
ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC
AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG
TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA
CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC
AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC
CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC
AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC
AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG
CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC
CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC
TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA
ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG
ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG
ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGTTAGAGATGTTTATGATTACTTCCGAGCTGTCCTGCAGCGTGATGAAAGAAGTG
AACGAGCTTTTAAGCTAACCCGGGATGCTATTGAGTTAAATGCAGCCAATTATACAGTGTGGCATTTCCGGAGAGTTCTTTTGAAGTCAC
TTCAGAAGGATCTACATGAGGAAATGAACTACATCACTGCAATAATTGAGGAGCAGCCCAAAAACTATCAAGTTTGGCATCATAGGCGAG
TATTAGTGGAATGGCTAAGAGATCCATCTCAGGAGCTTGAATTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTATCATGCCTGGC
AGCATCGACAATGGGTTATTCAGGAATTTAAACTTTGGGATAATGAGCTGCAGTATGTGGACCAACTTCTGAAAGAGGATGTGAGAAATA
ACTCTGTCTGGAACCAAAGATACTTCGTTATTTCTAACACCACTGGCTACAATGATCGTGCTGTATTGGAGAGAGAAGTCCAATACACTC
TGGAAATGATTAAACTAGTACCACATAATGAAAGTGCATGGAACTATTTGAAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATATCCTA
ATCTGTTAAATCAATTACTTGATTTACAACCAAGTCATAGTTCCCCCTACCTAATTGCCTTTCTTGTGGATATCTATGAAGACATGCTAG
AAAATCAGTGTGACAATAAGGAAGACATTCTTAATAAAGCATTAGAGTTATGTGAAATCCTAGCTAAAGAAAAGGACACTATAAGAAAGG
AATATTGGAGATACATTGGAAGATCCCTTCAAAGCAAACACAGCACAGAAAATGACTCACCAACAAATGTACAGCAATAACACCATCCAG
AAGAACTTGATGGAATGCTTTTATTTTTTATTAAGGGACCCTGCAGGAGTTTCACACGAGAGTGGTCCTTCCCTTTGCCTGTGGTGTAAA
AGTGCATCACACAGGTATTGCTTTTTAACAAGAACTGATGCTCCTTGGGTGCTGCTGCTACTCAGACTAGCTCTAAGTAATGTGATTCTT
CTAAAGCAAAGTCATTGGATGGGAGGAGGAAGAAAAAGTCCCATAAAGGAACTTTTGTAGTCTTATCAACATATAATCTAATCCCTTAGC
ATCAGCTCCTCCCTCAGTGGTACATGCGTCAAGATTTGTAGCAGTAATAACTGCAGGTCACTTGTATGTAATGGATGTGAGGTAGCCGAA
GTTTGGTTCAGTAAGCAGGGAATACAGTCGTTCCATCAGAGCTGGTCTGCACACTCACATTATCTTGCTATCACTGTAACCAACTAATGC

>57_57_2_AAK1-FNTA_AAK1_chr2_69732700_ENST00000409085_FNTA_chr8_42919243_ENST00000302279_length(amino acids)=1073AA_BP=789
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGF
AIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFT
ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
IITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNS
PIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ
PKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT
QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPV
RQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVY
NPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTVRDVYDYFRAVLQRDERSERA
FKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHR
QWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLL

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Fusion Gene PPI Analysis for AAK1-FNTA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AAK1-FNTA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AAK1-FNTA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource