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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:APP-PRKAA1 (FusionGDB2 ID:5701) |
Fusion Gene Summary for APP-PRKAA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APP-PRKAA1 | Fusion gene ID: 5701 | Hgene | Tgene | Gene symbol | APP | PRKAA1 | Gene ID | 351 | 5562 |
| Gene name | amyloid beta precursor protein | protein kinase AMP-activated catalytic subunit alpha 1 | |
| Synonyms | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 | AMPK|AMPKa1 | |
| Cytomap | 21q21.3 | 5p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | amyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei | 5'-AMP-activated protein kinase catalytic subunit alpha-15'-AMP-activated protein kinase, catalytic alpha-1 chainACACA kinaseAMP -activate kinase alpha 1 subunitAMP-activated protein kinase, catalytic, alpha-1AMPK alpha 1AMPK subunit alpha-1HMGCR k | |
| Modification date | 20200329 | 20200327 | |
| UniProtAcc | P05067 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000474136, ENST00000346798, ENST00000348990, ENST00000354192, ENST00000357903, ENST00000358918, ENST00000359726, ENST00000439274, ENST00000440126, ENST00000448388, | ENST00000296800, ENST00000354209, ENST00000397128, | |
| Fusion gene scores | * DoF score | 31 X 25 X 12=9300 | 9 X 8 X 4=288 |
| # samples | 33 | 10 | |
| ** MAII score | log2(33/9300*10)=-4.81669278663694 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: APP [Title/Abstract] AND PRKAA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | APP(27423315)-PRKAA1(40775605), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APP | GO:0001934 | positive regulation of protein phosphorylation | 11404397 |
| Hgene | APP | GO:0008285 | negative regulation of cell proliferation | 22944668 |
| Hgene | APP | GO:1905606 | regulation of presynapse assembly | 19726636 |
| Tgene | PRKAA1 | GO:0006468 | protein phosphorylation | 17028174 |
| Tgene | PRKAA1 | GO:0010508 | positive regulation of autophagy | 22012985 |
| Tgene | PRKAA1 | GO:0010628 | positive regulation of gene expression | 17028174 |
| Fusion gene breakpoints across APP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PRKAA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CG-5718 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
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Fusion Gene ORF analysis for APP-PRKAA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000474136 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| 5UTR-3CDS | ENST00000474136 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| 5UTR-3CDS | ENST00000474136 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000346798 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000346798 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000346798 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000348990 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000348990 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000348990 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000354192 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000354192 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000354192 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000357903 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000357903 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000357903 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000358918 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000358918 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000358918 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000359726 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000359726 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000359726 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000439274 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000439274 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000439274 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000440126 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000440126 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000440126 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000448388 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000448388 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| In-frame | ENST00000448388 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000346798 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5506 | 696 | 34 | 2106 | 690 |
| ENST00000346798 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2160 | 696 | 34 | 2151 | 705 |
| ENST00000346798 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1576 | 696 | 34 | 1077 | 347 |
| ENST00000354192 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5431 | 621 | 127 | 2031 | 634 |
| ENST00000354192 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2085 | 621 | 127 | 2076 | 649 |
| ENST00000354192 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1501 | 621 | 127 | 1002 | 291 |
| ENST00000348990 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5619 | 809 | 147 | 2219 | 690 |
| ENST00000348990 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2273 | 809 | 147 | 2264 | 705 |
| ENST00000348990 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1689 | 809 | 147 | 1190 | 347 |
| ENST00000357903 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5639 | 829 | 167 | 2239 | 690 |
| ENST00000357903 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2293 | 829 | 167 | 2284 | 705 |
| ENST00000357903 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1709 | 829 | 167 | 1210 | 347 |
| ENST00000358918 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5672 | 862 | 200 | 2272 | 690 |
| ENST00000358918 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2326 | 862 | 200 | 2317 | 705 |
| ENST00000358918 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1742 | 862 | 200 | 1243 | 347 |
| ENST00000359726 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5672 | 862 | 200 | 2272 | 690 |
| ENST00000359726 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2326 | 862 | 200 | 2317 | 705 |
| ENST00000359726 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1742 | 862 | 200 | 1243 | 347 |
| ENST00000448388 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5559 | 749 | 168 | 2159 | 663 |
| ENST00000448388 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2213 | 749 | 168 | 2204 | 678 |
| ENST00000448388 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1629 | 749 | 168 | 1130 | 320 |
| ENST00000440126 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5723 | 913 | 239 | 2323 | 694 |
| ENST00000440126 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 2377 | 913 | 239 | 2368 | 709 |
| ENST00000440126 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1793 | 913 | 239 | 1294 | 351 |
| ENST00000439274 | APP | chr21 | 27423315 | - | ENST00000397128 | PRKAA1 | chr5 | 40775605 | - | 5338 | 528 | 34 | 1938 | 634 |
| ENST00000439274 | APP | chr21 | 27423315 | - | ENST00000354209 | PRKAA1 | chr5 | 40775605 | - | 1992 | 528 | 34 | 1983 | 649 |
| ENST00000439274 | APP | chr21 | 27423315 | - | ENST00000296800 | PRKAA1 | chr5 | 40775605 | - | 1408 | 528 | 34 | 909 | 291 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000346798 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000189069 | 0.999811 |
| ENST00000346798 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.002200527 | 0.99779946 |
| ENST00000346798 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000302391 | 0.9996977 |
| ENST00000354192 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000178748 | 0.99982125 |
| ENST00000354192 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.001589306 | 0.9984107 |
| ENST00000354192 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000389258 | 0.9996107 |
| ENST00000348990 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000198636 | 0.99980134 |
| ENST00000348990 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.00289642 | 0.9971035 |
| ENST00000348990 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000415456 | 0.9995845 |
| ENST00000357903 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000199877 | 0.99980015 |
| ENST00000357903 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.003112432 | 0.9968876 |
| ENST00000357903 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000437578 | 0.99956244 |
| ENST00000358918 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000207447 | 0.9997925 |
| ENST00000358918 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.003416888 | 0.99658316 |
| ENST00000358918 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000527011 | 0.99947304 |
| ENST00000359726 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000207447 | 0.9997925 |
| ENST00000359726 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.003416888 | 0.99658316 |
| ENST00000359726 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000527011 | 0.99947304 |
| ENST00000448388 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000212453 | 0.9997875 |
| ENST00000448388 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.002536825 | 0.9974631 |
| ENST00000448388 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.00025357 | 0.9997464 |
| ENST00000440126 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000220824 | 0.99977916 |
| ENST00000440126 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.001147707 | 0.99885225 |
| ENST00000440126 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000234275 | 0.9997657 |
| ENST00000439274 | ENST00000397128 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000173841 | 0.99982613 |
| ENST00000439274 | ENST00000354209 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.001315367 | 0.9986846 |
| ENST00000439274 | ENST00000296800 | APP | chr21 | 27423315 | - | PRKAA1 | chr5 | 40775605 | - | 0.000321278 | 0.99967873 |
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Fusion Genomic Features for APP-PRKAA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for APP-PRKAA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27423315/chr5:40775605) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APP | . |
| FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.; FUNCTION: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 28_189 | 220 | 771.0 | Domain | E1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 28_189 | 220 | 696.0 | Domain | E1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 28_189 | 220 | 752.0 | Domain | E1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 28_189 | 220 | 753.0 | Domain | E1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 28_189 | 220 | 715.0 | Domain | E1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 28_189 | 215 | 747.0 | Domain | E1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 131_189 | 220 | 771.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 181_188 | 220 | 771.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 28_123 | 220 | 771.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 96_110 | 220 | 771.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 131_189 | 220 | 696.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 181_188 | 220 | 696.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 28_123 | 220 | 696.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 96_110 | 220 | 696.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 28_123 | 164 | 640.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 96_110 | 164 | 640.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 131_189 | 220 | 752.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 181_188 | 220 | 752.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 28_123 | 220 | 752.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 96_110 | 220 | 752.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 131_189 | 220 | 753.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 181_188 | 220 | 753.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 28_123 | 220 | 753.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 96_110 | 220 | 753.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 131_189 | 220 | 715.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 181_188 | 220 | 715.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 28_123 | 220 | 715.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 96_110 | 220 | 715.0 | Region | Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 131_189 | 215 | 747.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 181_188 | 215 | 747.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 28_123 | 215 | 747.0 | Region | GFLD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 96_110 | 215 | 747.0 | Region | Heparin-binding |
| Tgene | PRKAA1 | chr21:27423315 | chr5:40775605 | ENST00000354209 | 1 | 10 | 302_381 | 89 | 575.0 | Region | Note=AIS | |
| Tgene | PRKAA1 | chr21:27423315 | chr5:40775605 | ENST00000397128 | 1 | 9 | 302_381 | 89 | 560.0 | Region | Note=AIS |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 230_260 | 220 | 771.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 274_280 | 220 | 771.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 230_260 | 220 | 696.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 274_280 | 220 | 696.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 230_260 | 164 | 640.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 274_280 | 164 | 640.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 230_260 | 220 | 752.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 274_280 | 220 | 752.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 230_260 | 220 | 753.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 274_280 | 220 | 753.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 230_260 | 220 | 715.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 274_280 | 220 | 715.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 230_260 | 215 | 747.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 274_280 | 215 | 747.0 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 374_565 | 220 | 771.0 | Domain | E2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 374_565 | 220 | 696.0 | Domain | E2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 28_189 | 164 | 640.0 | Domain | E1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 374_565 | 164 | 640.0 | Domain | E2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 374_565 | 220 | 752.0 | Domain | E2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 374_565 | 220 | 753.0 | Domain | E2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 374_565 | 220 | 715.0 | Domain | E2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 374_565 | 215 | 747.0 | Domain | E2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 344_365 | 220 | 771.0 | Motif | OX-2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 724_734 | 220 | 771.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 344_365 | 220 | 696.0 | Motif | OX-2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 724_734 | 220 | 696.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 344_365 | 164 | 640.0 | Motif | OX-2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 724_734 | 164 | 640.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 344_365 | 220 | 752.0 | Motif | OX-2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 724_734 | 220 | 752.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 344_365 | 220 | 753.0 | Motif | OX-2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 724_734 | 220 | 753.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 344_365 | 220 | 715.0 | Motif | OX-2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 724_734 | 220 | 715.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 344_365 | 215 | 747.0 | Motif | OX-2 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 724_734 | 215 | 747.0 | Motif | Note=Basolateral sorting signal |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 391_423 | 220 | 771.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 491_522 | 220 | 771.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 523_540 | 220 | 771.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 391_423 | 220 | 696.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 491_522 | 220 | 696.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 523_540 | 220 | 696.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 131_189 | 164 | 640.0 | Region | CuBD subdomain |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 181_188 | 164 | 640.0 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 391_423 | 164 | 640.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 491_522 | 164 | 640.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 523_540 | 164 | 640.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 391_423 | 220 | 752.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 491_522 | 220 | 752.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 523_540 | 220 | 752.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 391_423 | 220 | 753.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 491_522 | 220 | 753.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 523_540 | 220 | 753.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 391_423 | 220 | 715.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 491_522 | 220 | 715.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 523_540 | 220 | 715.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 391_423 | 215 | 747.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 491_522 | 215 | 747.0 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 523_540 | 215 | 747.0 | Region | Collagen-binding |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 18_701 | 220 | 771.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 723_770 | 220 | 771.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 18_701 | 220 | 696.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 723_770 | 220 | 696.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 18_701 | 164 | 640.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 723_770 | 164 | 640.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 18_701 | 220 | 752.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 723_770 | 220 | 752.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 18_701 | 220 | 753.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 723_770 | 220 | 753.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 18_701 | 220 | 715.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 723_770 | 220 | 715.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 18_701 | 215 | 747.0 | Topological domain | Extracellular |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 723_770 | 215 | 747.0 | Topological domain | Cytoplasmic |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 702_722 | 220 | 771.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 702_722 | 220 | 696.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 702_722 | 164 | 640.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 702_722 | 220 | 752.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 702_722 | 220 | 753.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 702_722 | 220 | 715.0 | Transmembrane | Helical |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 702_722 | 215 | 747.0 | Transmembrane | Helical |
| Tgene | PRKAA1 | chr21:27423315 | chr5:40775605 | ENST00000354209 | 1 | 10 | 27_279 | 89 | 575.0 | Domain | Protein kinase | |
| Tgene | PRKAA1 | chr21:27423315 | chr5:40775605 | ENST00000397128 | 1 | 9 | 27_279 | 89 | 560.0 | Domain | Protein kinase | |
| Tgene | PRKAA1 | chr21:27423315 | chr5:40775605 | ENST00000354209 | 1 | 10 | 33_41 | 89 | 575.0 | Nucleotide binding | ATP | |
| Tgene | PRKAA1 | chr21:27423315 | chr5:40775605 | ENST00000397128 | 1 | 9 | 33_41 | 89 | 560.0 | Nucleotide binding | ATP |
Top |
Fusion Gene Sequence for APP-PRKAA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5701_5701_1_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1576nt_BP=696nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATC TGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCG GCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCT TGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACC CAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGA ACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACT ATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGT GAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAAT GAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTA ATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTG >5701_5701_1_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD -------------------------------------------------------------- >5701_5701_2_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2160nt_BP=696nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATC TGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGT AGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAG GCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAA CATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGG CCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCT TTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGA TCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATC ATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTA CAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTT GGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACC AAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAG TCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTT GCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGA TTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTG CCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGT TGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAA >5701_5701_2_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA -------------------------------------------------------------- >5701_5701_3_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5506nt_BP=696nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATC TGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCG GCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCT TGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACC CAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTT ATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTT AAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATG GTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATG TGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCAT AATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGAC TCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAA ACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAAT CAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAAT GAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGAC TGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGA AGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGA GATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCAC AGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACAT GATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGT GAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTC ATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGT TTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTT TTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGA TTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGT TTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCC ACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTA GCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACAC AAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCAT CATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCT TACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAA GCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGT TATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATC ACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATAT CATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTAC ATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGG TCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCT TAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTT GCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATA TTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGA CTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATT CAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCT TTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTT GTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAAT TGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCAC TTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGT GTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATT TTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGAT GTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAA ATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAA TAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCT AGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTG TGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAA TAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATT TGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTC >5701_5701_3_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN -------------------------------------------------------------- >5701_5701_4_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1689nt_BP=809nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGG TACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGA AGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGAT TTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTT TTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAA TTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTA AGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTC ACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGT TGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCA TCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAA >5701_5701_4_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD -------------------------------------------------------------- >5701_5701_5_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2273nt_BP=809nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGG TACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGA AGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTT TCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAG ATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTA ATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTT GATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTT TTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAA TATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAA GAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATG AATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTA CCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCA AAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGG AAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTG GATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGA TCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTG ACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAA >5701_5701_5_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA -------------------------------------------------------------- >5701_5701_6_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5619nt_BP=809nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGG TACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGA AGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGAT TTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTT TTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGC AGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGG ATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATC AAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGAT GATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCT TTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCT TTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGAT GAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATT ATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCT GTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAA ATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCT GAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGA AGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGC AATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGC AATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTAT GTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAA TATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCC AAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTC TTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAAC CTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTT CGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAG TGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCA GACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAA TATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAA TTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGAT TCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGA AAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCT ATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATT TGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTG TAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAA ACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAAC AAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACA CTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATG ATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATA TTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTC ATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCT TTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTAT TTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGAC TGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCA ATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATT TTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGA AATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGG TAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTA CTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATG TAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCT AATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATG ATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCT AGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCT TTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATT GTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAA >5701_5701_6_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN -------------------------------------------------------------- >5701_5701_7_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1501nt_BP=621nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGT CATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGA TGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACC TGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAAC AAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAA CTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAAC TCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAAC CATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAG ACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTT TTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTC >5701_5701_7_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=291AA_BP=164 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV -------------------------------------------------------------- >5701_5701_8_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2085nt_BP=621nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGT CATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATC TGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGT GGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGA TTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGG AAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGA CCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACA TATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTT TCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGT TCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGC CAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTT GGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCA TTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGT AAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAG AACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAG CAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACT TGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGC >5701_5701_8_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=649AA_BP=164 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME YVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATI KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNP VTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG -------------------------------------------------------------- >5701_5701_9_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5431nt_BP=621nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGT CATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGA TGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACC TGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAAC AAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGT TATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTA TACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATAT CAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGC CTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGT TGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGA TGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAA TCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGA AGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAG CACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGA AGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCA AGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACAC AATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCA TGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCA CAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAG CATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATT TACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTT TATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATAT CCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCT CCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTT TAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGA TTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAAT TTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCA CGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAA ATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCA TAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGA AAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGT ATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTT ACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTA ATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGAT CCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAAT TCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATT TTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATT GTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCT ATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGC TTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCC AGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTT TATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTT TAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATA GGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAAT ATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAA CCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAG GCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCT TGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATT TTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAA ATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATA CAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGG AACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCA TCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAG GTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATAT >5701_5701_9_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=634AA_BP=164 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERV PFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIK -------------------------------------------------------------- >5701_5701_10_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1709nt_BP=829nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTG ATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGC ATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACA TGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTA TAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAAC AGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAA TGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATT TTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAAT TTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTAT >5701_5701_10_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD -------------------------------------------------------------- >5701_5701_11_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2293nt_BP=829nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTG ATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGC GTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTG ATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCA ACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTAT TATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAA ATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGT TTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTG AAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAA TAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTC GGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAAC ACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCA AACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGA GTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTG CTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAG TTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGA >5701_5701_11_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA -------------------------------------------------------------- >5701_5701_12_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5639nt_BP=829nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTG ATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGC ATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACA TGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCC CAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTT TTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATC CCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCAT ATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACA ACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGG CGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAA GGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTC AAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGC GTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATT TCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCC AAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTG ACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACT TTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGA GGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTT TGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTA GTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATA AATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTA GTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTG TGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCC ACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCC ACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATG GTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAG CACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATA AATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGAT TATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTA TGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGT CATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGC TTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCT AAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTC TTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATT ATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTT CCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGA TAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTT CCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGA TGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTC AAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAA ATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGT TCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGG GGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCAT TTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTT TTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAAT TGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGAC TTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTA TAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGG GAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTA GTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTA ATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCA AATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCAC ATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTT >5701_5701_12_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN -------------------------------------------------------------- >5701_5701_13_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1742nt_BP=862nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC CAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTT GTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATT GAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATC TTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAA AATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTAT TTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTAT >5701_5701_13_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD -------------------------------------------------------------- >5701_5701_14_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2326nt_BP=862nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCT CCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCC ATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATG GTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATA TATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATAT GTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGG CCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCA TGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACC AGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCAC CTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATA CCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAA ATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGA AGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTG ATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATT CAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAA >5701_5701_14_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA -------------------------------------------------------------- >5701_5701_15_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5672nt_BP=862nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC CAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCC TTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGA TTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACC TTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGT GCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGA GAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTG AAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAA GGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATT ATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTAT ACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGA GATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCT CATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATC TAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCC ATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAA AGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTC AGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGT GTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTT AACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTG TCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAG CTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCC CAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCT CCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCA AAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTT GTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTA TTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGT GCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCT ACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATG CATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACT TCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCC ATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGT TATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTG GGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACAC AATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACT TTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTT TTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTG ACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTG AAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAA TTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAA GTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAA ACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTA TGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAAC AGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTT ATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTT GCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTG AGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCT TTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTT TGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCA CCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTT CCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTAT ATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTCCATTTATCATCTGT >5701_5701_15_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN -------------------------------------------------------------- >5701_5701_16_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1742nt_BP=862nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC CAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTT GTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATT GAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATC TTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAA AATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTAT TTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTAT >5701_5701_16_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD -------------------------------------------------------------- >5701_5701_17_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2326nt_BP=862nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCT CCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCC ATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATG GTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATA TATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATAT GTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGG CCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCA TGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACC AGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCAC CTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATA CCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAA ATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGA AGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTG ATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATT CAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAA >5701_5701_17_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA -------------------------------------------------------------- >5701_5701_18_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5672nt_BP=862nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC CAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCC TTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGA TTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACC TTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGT GCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGA GAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTG AAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAA GGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATT ATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTAT ACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGA GATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCT CATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATC TAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCC ATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAA AGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTC AGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGT GTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTT AACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTG TCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAG CTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCC CAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCT CCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCA AAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTT GTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTA TTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGT GCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCT ACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATG CATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACT TCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCC ATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGT TATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTG GGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACAC AATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACT TTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTT TTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTG ACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTG AAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAA TTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAA GTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAA ACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTA TGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAAC AGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTT ATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTT GCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTG AGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCT TTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTT TGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCA CCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTT CCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTAT ATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTCCATTTATCATCTGT >5701_5701_18_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN -------------------------------------------------------------- >5701_5701_19_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1408nt_BP=528nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCAT CAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGA AAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGA AAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAG TTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTA CCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCT TTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCAT GCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACT GCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTA AATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGG >5701_5701_19_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=291AA_BP=164 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV -------------------------------------------------------------- >5701_5701_20_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=1992nt_BP=528nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCAT CAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGA TGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGA TTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTT TGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAG ATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCA TGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATAT GCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCC TGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCT CAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAA AGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGT TGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTT AGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAA CCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAAC TTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAA CTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGA CTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACA >5701_5701_20_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=649AA_BP=164 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME YVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATI KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNP VTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG -------------------------------------------------------------- >5701_5701_21_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5338nt_BP=528nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCAT CAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGA AAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGA AAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAG TTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTAT TCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATAC CCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAG GGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTT AAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGC CTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGA TCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCC ACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGT ATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCAC TTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGC CAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGG AAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAAT AGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGC ATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAG GGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCAT AATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTAC ATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTAT AGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCC TCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCC GGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAG TGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTA CAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTA AATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGA TATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATT CCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAG AAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAA ACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATA GATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACA GACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATA ATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCA ATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCT ATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTT TTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTA TCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATT TTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTG CATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGG GCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTAT GTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAA AGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGA CCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATT TAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCT TTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCA ATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGA CAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTG CCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATA ATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAA AATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAAC TCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCT TCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTA GAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAAT >5701_5701_21_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=634AA_BP=164 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERV PFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIK -------------------------------------------------------------- >5701_5701_22_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1793nt_BP=913nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATA TCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGG TGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGT CAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAA TTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGA ATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACT TTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTAT TTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGA TTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAAT >5701_5701_22_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=351AA_BP=224 MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQIL -------------------------------------------------------------- >5701_5701_23_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2377nt_BP=913nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATA TCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGT TCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCAC ACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATG CTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTG GAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTT CTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAAC AGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGT TTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATA ACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCC ATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAG GTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAAT TGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTAC AGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTC CACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTC TTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTG >5701_5701_23_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=709AA_BP=224 MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTK ELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLD ELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE -------------------------------------------------------------- >5701_5701_24_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5723nt_BP=913nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATA TCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGG TGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGT CAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGG TAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGA AGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGA AGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTT CAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAA ATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAA GCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCAC GCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTC GACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTAC GAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTA GTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGA GTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAA CTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTT ATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTG GCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGT TCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTAC ACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATT TGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACA GTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCT CGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACA CCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACC TCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGT CATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAA TTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCAT ATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTA TCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACA TTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTG TTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTT CCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAAT CCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATA GCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTG ATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAG ATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAAT TGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATT GCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAA TGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGA AAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGA GTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGA TGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAG AAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGT TACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAA GCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTAC TAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATG CAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAG ATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTT AATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTT CAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTT GGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTT TTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAA CATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTT >5701_5701_24_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=694AA_BP=224 MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQIL SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSE EEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSG -------------------------------------------------------------- >5701_5701_25_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1629nt_BP=749nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGA GAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTAT TGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGT CTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGAC TGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAG TTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCT AGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATA CTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGG AGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGG TGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTT >5701_5701_25_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=320AA_BP=193 MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKI -------------------------------------------------------------- >5701_5701_26_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2213nt_BP=749nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGA GAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAA GAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAAT GTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGT GGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTC TATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCT CAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAA CATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAA GAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTAC CATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCAT CACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAG AAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGT AGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTAC TCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAA TCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAA TCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAA >5701_5701_26_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=678AA_BP=193 MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDL KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPL AVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIM AEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAE -------------------------------------------------------------- >5701_5701_27_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5559nt_BP=749nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGA GAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTAT TGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGT CTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTG TATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTG CCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTG CAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAG GATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGC TGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGAT TTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCT GAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGA ATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCA TATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTAT CTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTAT CGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCT TCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAA ACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAA TTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATT AAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTAT TTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAAT TTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCT TCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAG TGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACA GGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGAC CGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCT GTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCA GATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATAT ACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTA CTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCA AATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTT AATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTAT GTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATG ACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAAC TCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAA CATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGAT ACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAG TCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTAT TAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTA TGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATG CACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAG TTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGC AGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTT GTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTAT TGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCA GTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTT GTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATAT TTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATA GTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTG GGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGA TGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTA CATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGT GTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAAT GAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAG >5701_5701_27_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=663AA_BP=193 MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKI ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLL KHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMN EAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWK VVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for APP-PRKAA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 732_751 | 220.66666666666666 | 771.0 | G(o)-alpha |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 732_751 | 220.66666666666666 | 696.0 | G(o)-alpha |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 732_751 | 164.66666666666666 | 640.0 | G(o)-alpha |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 732_751 | 220.66666666666666 | 752.0 | G(o)-alpha |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 732_751 | 220.66666666666666 | 753.0 | G(o)-alpha |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 732_751 | 220.66666666666666 | 715.0 | G(o)-alpha |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 732_751 | 215.66666666666666 | 747.0 | G(o)-alpha |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000346798 | - | 5 | 18 | 695_722 | 220.66666666666666 | 771.0 | PSEN1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000348990 | - | 5 | 16 | 695_722 | 220.66666666666666 | 696.0 | PSEN1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000354192 | - | 4 | 15 | 695_722 | 164.66666666666666 | 640.0 | PSEN1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000357903 | - | 5 | 17 | 695_722 | 220.66666666666666 | 752.0 | PSEN1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000358918 | - | 5 | 17 | 695_722 | 220.66666666666666 | 753.0 | PSEN1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000359726 | - | 5 | 17 | 695_722 | 220.66666666666666 | 715.0 | PSEN1 |
| Hgene | APP | chr21:27423315 | chr5:40775605 | ENST00000440126 | - | 5 | 17 | 695_722 | 215.66666666666666 | 747.0 | PSEN1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APP-PRKAA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for APP-PRKAA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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