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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAA60-TNFRSF12A (FusionGDB2 ID:57018)

Fusion Gene Summary for NAA60-TNFRSF12A

check button Fusion gene summary
Fusion gene informationFusion gene name: NAA60-TNFRSF12A
Fusion gene ID: 57018
HgeneTgene
Gene symbol

NAA60

TNFRSF12A

Gene ID

79903

51330

Gene nameN-alpha-acetyltransferase 60, NatF catalytic subunitTNF receptor superfamily member 12A
SynonymsHAT4|NAT15|NatF|hNaa60CD266|FN14|TWEAKR
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionN-alpha-acetyltransferase 60N-acetyltransferase 15 (GCN5-related, putative)N-alpha-acetyltransferase Fepididymis secretory sperm binding proteinhistone acetyltransferase type B protein 4tumor necrosis factor receptor superfamily member 12AFGF-inducible 14fibroblast growth factor-inducible immediate-early response protein 14tweak-receptortype I transmembrane protein Fn14
Modification date2020031320200313
UniProtAcc

Q9H7X0

.
Ensembl transtripts involved in fusion geneENST00000570551, ENST00000360862, 
ENST00000414063, ENST00000421765, 
ENST00000570819, ENST00000572942, 
ENST00000575076, ENST00000576916, 
ENST00000577013, ENST00000608993, 
ENST00000610180, ENST00000407558, 
ENST00000424546, ENST00000572584, 
ENST00000573580, ENST00000576906, 
ENST00000608722, 		ENST00000326577, 
ENST00000341627, ENST00000573001, 
ENST00000575124, 
Fusion gene scores* DoF score10 X 8 X 7=5603 X 3 X 2=18
# samples 123
** MAII scorelog2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NAA60 [Title/Abstract] AND TNFRSF12A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAA60(3508181)-TNFRSF12A(3071556), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAA60

GO:0006334

nucleosome assembly

21981917

HgeneNAA60

GO:0006474

N-terminal protein amino acid acetylation

25732826|27320834|27550639

HgeneNAA60

GO:0017196

N-terminal peptidyl-methionine acetylation

21750686

HgeneNAA60

GO:0043967

histone H4 acetylation

21981917

TgeneTNFRSF12A

GO:0043065

positive regulation of apoptotic process

21525013

TgeneTNFRSF12A

GO:0061041

regulation of wound healing

11728344


check buttonFusion gene breakpoints across NAA60 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNFRSF12A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8525-01ANAA60chr16

3508181

+TNFRSF12Achr16

3071556

+


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Fusion Gene ORF analysis for NAA60-TNFRSF12A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000570551ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
3UTR-3CDSENST00000570551ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
3UTR-3CDSENST00000570551ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
3UTR-3CDSENST00000570551ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000360862ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000360862ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000360862ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000360862ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000414063ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000414063ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000414063ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000414063ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000421765ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000421765ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000421765ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000421765ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000570819ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000570819ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000570819ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000570819ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000572942ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000572942ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000572942ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000572942ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000575076ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000575076ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000575076ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000575076ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000576916ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000576916ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000576916ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000576916ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000577013ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000577013ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000577013ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000577013ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000608993ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000608993ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000608993ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000608993ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000610180ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000610180ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000610180ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
5UTR-3CDSENST00000610180ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000407558ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000407558ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000407558ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000407558ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000424546ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000424546ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000424546ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000424546ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000572584ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000572584ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000572584ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000572584ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000573580ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000573580ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000573580ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000573580ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000576906ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000576906ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000576906ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000576906ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000608722ENST00000326577NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000608722ENST00000341627NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000608722ENST00000573001NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+
intron-3CDSENST00000608722ENST00000575124NAA60chr16

3508181

+TNFRSF12Achr16

3071556

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NAA60-TNFRSF12A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NAA60chr163508181+TNFRSF12Achr163071555+3.24E-060.9999968
NAA60chr163508181+TNFRSF12Achr163071555+3.24E-060.9999968

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NAA60-TNFRSF12A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3508181/:3071556)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAA60

Q9H7X0

.
FUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). {ECO:0000269|PubMed:21750686, ECO:0000269|PubMed:25732826, ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639, ECO:0000305|PubMed:21981917}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NAA60-TNFRSF12A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NAA60-TNFRSF12A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAA60-TNFRSF12A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAA60-TNFRSF12A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource