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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAALADL2-NLGN1 (FusionGDB2 ID:57039)

Fusion Gene Summary for NAALADL2-NLGN1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAALADL2-NLGN1
Fusion gene ID: 57039
HgeneTgene
Gene symbol

NAALADL2

NLGN1

Gene ID

254827

22871

Gene nameN-acetylated alpha-linked acidic dipeptidase like 2neuroligin 1
Synonyms-NL1
Cytomap

3q26.31

3q26.31

Type of geneprotein-codingprotein-coding
Descriptioninactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologueneuroligin-1
Modification date2020031320200313
UniProtAcc.

Q8N2Q7

Ensembl transtripts involved in fusion geneENST00000454872, ENST00000473253, 
ENST00000466350, ENST00000361589, 
ENST00000457714, ENST00000401917, 
ENST00000545397, 
Fusion gene scores* DoF score28 X 19 X 9=478813 X 8 X 9=936
# samples 2915
** MAII scorelog2(29/4788*10)=-4.04529834692857
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAALADL2 [Title/Abstract] AND NLGN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAALADL2(174577240)-NLGN1(173322069), # samples:2
NAALADL2(174577240)-NLGN1(173993105), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNLGN1

GO:0031175

neuron projection development

22750515

TgeneNLGN1

GO:0051965

positive regulation of synapse assembly

24613359


check buttonFusion gene breakpoints across NAALADL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NLGN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27M-01ANAALADL2chr3

174577240

-NLGN1chr3

173322069

+
ChimerDB4BRCATCGA-D8-A27M-01ANAALADL2chr3

174577240

+NLGN1chr3

173322069

+
ChimerDB4PRADTCGA-YL-A8S8-01ANAALADL2chr3

174577240

-NLGN1chr3

173993105

+
ChimerDB4PRADTCGA-YL-A8S8NAALADL2chr3

174577240

+NLGN1chr3

173993105

+


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Fusion Gene ORF analysis for NAALADL2-NLGN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000454872ENST00000466350NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
5CDS-5UTRENST00000454872ENST00000361589NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
5CDS-5UTRENST00000454872ENST00000457714NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
5CDS-intronENST00000454872ENST00000401917NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
5CDS-intronENST00000454872ENST00000466350NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
5CDS-intronENST00000454872ENST00000545397NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
In-frameENST00000454872ENST00000361589NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
In-frameENST00000454872ENST00000401917NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
In-frameENST00000454872ENST00000457714NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
In-frameENST00000454872ENST00000545397NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
intron-3CDSENST00000473253ENST00000361589NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
intron-3CDSENST00000473253ENST00000401917NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
intron-3CDSENST00000473253ENST00000457714NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
intron-3CDSENST00000473253ENST00000545397NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
intron-3UTRENST00000473253ENST00000466350NAALADL2chr3

174577240

+NLGN1chr3

173993105

+
intron-5UTRENST00000473253ENST00000361589NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
intron-5UTRENST00000473253ENST00000457714NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
intron-intronENST00000473253ENST00000401917NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
intron-intronENST00000473253ENST00000466350NAALADL2chr3

174577240

+NLGN1chr3

173322069

+
intron-intronENST00000473253ENST00000545397NAALADL2chr3

174577240

+NLGN1chr3

173322069

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000454872NAALADL2chr3174577240+ENST00000457714NLGN1chr3173993105+73381711281996622
ENST00000454872NAALADL2chr3174577240+ENST00000361589NLGN1chr3173993105+38171711281996622
ENST00000454872NAALADL2chr3174577240+ENST00000401917NLGN1chr3173993105+19971711281996623
ENST00000454872NAALADL2chr3174577240+ENST00000545397NLGN1chr3173993105+22441711281996622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000454872ENST00000457714NAALADL2chr3174577240+NLGN1chr3173993105+0.0002418930.99975806
ENST00000454872ENST00000361589NAALADL2chr3174577240+NLGN1chr3173993105+0.0003450680.9996549
ENST00000454872ENST00000401917NAALADL2chr3174577240+NLGN1chr3173993105+0.0015217870.99847823
ENST00000454872ENST00000545397NAALADL2chr3174577240+NLGN1chr3173993105+0.0010828970.9989171

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Fusion Genomic Features for NAALADL2-NLGN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NAALADL2chr3174577240+NLGN1chr3173322068+0.0028955860.99710447
NAALADL2chr3174577240+NLGN1chr3173993104+8.12E-050.9999188
NAALADL2chr3174577240+NLGN1chr3173322068+0.0028955860.99710447
NAALADL2chr3174577240+NLGN1chr3173993104+8.12E-050.9999188

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NAALADL2-NLGN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:174577240/chr3:173322069)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NLGN1

Q8N2Q7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. {ECO:0000250|UniProtKB:Q99K10, ECO:0000269|PubMed:28841651}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNLGN1chr3:174577240chr3:173993105ENST0000036158926739_863215824.0Topological domainCytoplasmic
TgeneNLGN1chr3:174577240chr3:173993105ENST0000045771437739_863215824.0Topological domainCytoplasmic
TgeneNLGN1chr3:174577240chr3:173993105ENST0000054539716739_863215709.0Topological domainCytoplasmic
TgeneNLGN1chr3:174577240chr3:173993105ENST0000036158926718_738215824.0TransmembraneHelical
TgeneNLGN1chr3:174577240chr3:173993105ENST0000045771437718_738215824.0TransmembraneHelical
TgeneNLGN1chr3:174577240chr3:173993105ENST0000054539716718_738215709.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAALADL2chr3:174577240chr3:173993105ENST00000454872+114143_79514796.0Topological domainExtracellular
HgeneNAALADL2chr3:174577240chr3:173993105ENST00000454872+1141_12114796.0Topological domainCytoplasmic
HgeneNAALADL2chr3:174577240chr3:173993105ENST00000454872+114122_14214796.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneNLGN1chr3:174577240chr3:173993105ENST000003615892646_717215824.0Topological domainExtracellular
TgeneNLGN1chr3:174577240chr3:173993105ENST000004577143746_717215824.0Topological domainExtracellular
TgeneNLGN1chr3:174577240chr3:173993105ENST000005453971646_717215709.0Topological domainExtracellular


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Fusion Gene Sequence for NAALADL2-NLGN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57039_57039_1_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000361589_length(transcript)=3817nt_BP=171nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTTTCTTGA
GTACAGGCGATCAGGCTGCAAAGGGGAACTATGGACTCCTTGATCTCATACAAGCTTTAAGATGGACTAGTGAAAACATTGGATTCTTTG
GTGGTGACCCCTTAAGAATCACTGTTTTTGGATCTGGTGCTGGGGGTTCATGTGTCAACCTGCTGACTTTATCCCATTATTCTGAAGGTA
ACCGTTGGAGCAATTCAACCAAAGGACTTTTTCAACGAGCAATAGCTCAAAGTGGAACAGCCCTTTCCAGCTGGGCTGTTAGTTTTCAAC
CTGCAAAATATGCTAGAATGTTGGCCACAAAAGTTGGTTGCAATGTTTCAGATACAGTAGAGTTAGTGGAATGCCTACAGAAGAAGCCTT
ACAAAGAACTTGTTGACCAAGATATTCAACCAGCTCGATACCACATAGCCTTTGGACCTGTGATTGATGGTGATGTAATACCAGACGACC
CCCAGATATTGATGGAGCAAGGAGAGTTTCTCAACTATGATATAATGTTAGGAGTGAACCAAGGGGAAGGGTTAAAATTTGTTGAAAATA
TAGTAGATAGCGATGATGGTATATCAGCTAGTGATTTTGACTTTGCTGTTTCAAATTTTGTTGATAATTTATATGGATATCCTGAAGGCA
AAGATGTTTTGAGAGAAACCATTAAGTTCATGTATACTGACTGGGCTGACCGTCATAACCCTGAAACCAGAAGAAAGACATTACTGGCTT
TGTTTACGGACCATCAGTGGGTGGCACCAGCTGTAGCCACAGCGGATCTTCACTCAAACTTTGGTTCACCTACGTACTTCTATGCCTTTT
ACCATCATTGCCAAACAGATCAGGTTCCAGCTTGGGCTGATGCAGCCCACGGAGACGAGGTTCCCTATGTACTGGGAATCCCCATGATTG
GCCCTACAGAGTTATTTCCTTGCAATTTCTCCAAAAATGATGTGATGCTGAGTGCAGTTGTAATGACATACTGGACAAATTTTGCTAAAA
CTGGTGACCCAAATCAACCAGTCCCTCAAGACACGAAATTCATTCATACCAAACCCAACCGTTTTGAAGAAGTAGCATGGACCAGATATT
CCCAGAAAGACCAACTTTATCTCCATATTGGATTAAAACCAAGAGTTAAAGAACATTACAGAGCCAATAAGGTGAACCTCTGGTTGGAGT
TGGTACCTCATCTGCATAATCTCAATGACATTTCTCAGTATACCTCTACAACAACTAAAGTGCCATCAACTGACATCACTTTCAGACCTA
CGAGAAAAAATTCTGTACCTGTCACGTCAGCCTTTCCCACTGCCAAGCAGGATGATCCCAAACAACAACCAAGTCCATTTTCAGTGGATC
AAAGGGACTACTCAACAGAGCTGAGTGTCACTATTGCAGTTGGAGCATCACTGCTGTTTCTGAACATCTTGGCCTTTGCAGCCCTGTACT
ACAAAAAGGATAAGAGGAGACATGATGTTCACAGGAGATGCAGCCCTCAGCGCACTACTACCAATGATCTAACCCATGCACAAGAAGAGG
AAATCATGTCCCTCCAAATGAAGCACACTGATTTGGATCATGAATGTGAGTCCATTCATCCACATGAGGTGGTTCTTCGGACCGCCTGTC
CCCCAGATTACACACTAGCTATGAGGAGGTCACCTGATGATGTTCCCTTAATGACACCCAACACCATTACAATGATTCCCAACACTATAC
CAGGGATTCAGCCCTTACACACATTCAATACATTTACTGGAGGACAGAACAATACTCTGCCCCATCCCCATCCCCACCCCCATTCACATT
CAACAACCAGGGTATAGCCAGATAAGAGAAACAAACTATTTTTTTTGATGGATTGCAGTAAACGATCACTGAAGATTCCTTGGCTTTCAA
CCTACAAGACTTACTATTTAAATAAGGAGGAATATTATGTGAATATACATATCAAGAACTTTGGGGGTTTTGAAAAAAATGAATTGTATA
TATACAAATCAACTTTAAAAACAAATTTCAATTGCTTGAAGCAATTGTTCTGAATGATACTTTTTCATTCACATTCAAGAATTAATTTTT
TGAAGATTTAAGTTACATAATGGAATTAGGCATGTGGAACACCAAACAGGAAAGAACTATGTCTGAAATATAAAAAATAAAAATAAAAAA
ACAACTATGAATATGCACAAGGGACACACCAGTGGAATGTCAGATAATTTTCACCAGTTTTTATTTGGAGCCGTTTTATTGTGTAGACCA
TATTTACATATTTGGATAAGTACACAAAGCGTCAATGCTGTTAATGGCCTTAGCAAAGGCTCATGCTGAAATTTGCCAGTAAAACAAAGA
AGTTTAAAGACTGGCAGGTACACCATTATCACATAAGTGCTGTCAGTATAAAGTTGTGGGGATAAAGGAAACTGGATATTTTTAGCACGA
TGTGCATGATAATTTATATGCTTGGTGGCTGTGCTGCTGATTAAGCCGTAATTAAAATTCTTCTCATCCCATTGGAGTTTTTAATAGAAG
CTTCCTCCATCAATTGGCAGAACCTAAAGAAGATTTTAAGGGGCAAAAGTAATTACAATAAAATAATTCACAGTAGTTTCAATATAGAAG
GAATTAGCTATTAAAGGTATTTGAAGAAACTATAGGTATAGTGGTGAATACTCGCTGATATGAATCCCAGAAAAAAATTTCCTGTTTTTA
ATGTTCTTTTCAATCCCATCTAGATAATTTATAGAAATATAACCCTAATTGGACATGTGGTACAGGATCTATAAGTTGCTGTGTTTTTTT
GTTACTCTGTATTTTGTTCCTTTTGGTAAGGTGAAGTGTGTCCAAAGAGTTACTTGCAACAGTCTTTCATGATATGAGGATGCCCCCGTA
TTACCACTCTGATTATAGTTCTGAGTTCTTTGATTTACTCATGCTGCATGACAAAATGTTTACTAATAACAATTCATTATAAAGTTATAT
CCCTCTTTACATCACTTATCTTTCTCACTGAGGTTCATTCACTGGAATTTACTCACGCAATCTCAGTAGAGTACAACGTAGATACAGAAC
CTAGGAGAGTCAACATCTGGAGGATTTTAGTCTTTCTTACACATATGTGTGATTTTAAACGAATATTCTCAGACCACAGGAAACTCTTCA
TCCCCCTGTTGTTTACCAGTAACAGTATATCACAGACCTTTCCAAATGTTTGTATATGTAATCAGATGTACATTTATATTGAAAAACAAA
TGAGATGGACTTAAAGAGCACATCCTGATAAATACTTTCTCTCTCACCTGTACTATATTTCTATTAGACTAAAGTTATGTGATTTTTTTT
TTACATTTTTTCAGATGACTAGCAATTTTGATAGTTTATAAGATAATGCAAAGAACTTTCTCTGACAAACTAACTGCAGTAACAGAAACC
TTTCTTTTCAGTTACTCTTTTTCAAGAATGAAAGATTATTATACAAAAAATTGTATACTACTTGATGGAACCAACTTTGTACATCTTGGC
CATGTCACTGGTCATTGTGTGAAATAAAGATAATCTGGATAATGACTATTAGTCCAATGCTAAGAAACATGATCTTTGCTCATTAAAGAG

>57039_57039_1_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000361589_length(amino acids)=622AA_BP=14
MGENEASLPNTSLQGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQR
AIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNY
DIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVA
TADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTK
FIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFP
TAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLD

--------------------------------------------------------------
>57039_57039_2_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000401917_length(transcript)=1997nt_BP=171nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTTTCTTGA
GTACAGGCGATCAGGCTGCAAAGGGGAACTATGGACTCCTTGATCTCATACAAGCTTTAAGATGGACTAGTGAAAACATTGGATTCTTTG
GTGGTGACCCCTTAAGAATCACTGTTTTTGGATCTGGTGCTGGGGGTTCATGTGTCAACCTGCTGACTTTATCCCATTATTCTGAAGGTA
ACCGTTGGAGCAATTCAACCAAAGGACTTTTTCAACGAGCAATAGCTCAAAGTGGAACAGCCCTTTCCAGCTGGGCTGTTAGTTTTCAAC
CTGCAAAATATGCTAGAATGTTGGCCACAAAAGTTGGTTGCAATGTTTCAGATACAGTAGAGTTAGTGGAATGCCTACAGAAGAAGCCTT
ACAAAGAACTTGTTGACCAAGATATTCAACCAGCTCGATACCACATAGCCTTTGGACCTGTGATTGATGGTGATGTAATACCAGACGACC
CCCAGATATTGATGGAGCAAGGAGAGTTTCTCAACTATGATATAATGTTAGGAGTGAACCAAGGGGAAGGGTTAAAATTTGTTGAAAATA
TAGTAGATAGCGATGATGGTATATCAGCTAGTGATTTTGACTTTGCTGTTTCAAATTTTGTTGATAATTTATATGGATATCCTGAAGGCA
AAGATGTTTTGAGAGAAACCATTAAGTTCATGTATACTGACTGGGCTGACCGTCATAACCCTGAAACCAGAAGAAAGACATTACTGGCTT
TGTTTACGGACCATCAGTGGGTGGCACCAGCTGTAGCCACAGCGGATCTTCACTCAAACTTTGGTTCACCTACGTACTTCTATGCCTTTT
ACCATCATTGCCAAACAGATCAGGTTCCAGCTTGGGCTGATGCAGCCCACGGAGACGAGGTTCCCTATGTACTGGGAATCCCCATGATTG
GCCCTACAGAGTTATTTCCTTGCAATTTCTCCAAAAATGATGTGATGCTGAGTGCAGTTGTAATGACATACTGGACAAATTTTGCTAAAA
CTGGTGACCCAAATCAACCAGTCCCTCAAGACACGAAATTCATTCATACCAAACCCAACCGTTTTGAAGAAGTAGCATGGACCAGATATT
CCCAGAAAGACCAACTTTATCTCCATATTGGATTAAAACCAAGAGTTAAAGAACATTACAGAGCCAATAAGGTGAACCTCTGGTTGGAGT
TGGTACCTCATCTGCATAATCTCAATGACATTTCTCAGTATACCTCTACAACAACTAAAGTGCCATCAACTGACATCACTTTCAGACCTA
CGAGAAAAAATTCTGTACCTGTCACGTCAGCCTTTCCCACTGCCAAGCAGGATGATCCCAAACAACAACCAAGTCCATTTTCAGTGGATC
AAAGGGACTACTCAACAGAGCTGAGTGTCACTATTGCAGTTGGAGCATCACTGCTGTTTCTGAACATCTTGGCCTTTGCAGCCCTGTACT
ACAAAAAGGATAAGAGGAGACATGATGTTCACAGGAGATGCAGCCCTCAGCGCACTACTACCAATGATCTAACCCATGCACAAGAAGAGG
AAATCATGTCCCTCCAAATGAAGCACACTGATTTGGATCATGAATGTGAGTCCATTCATCCACATGAGGTGGTTCTTCGGACCGCCTGTC
CCCCAGATTACACACTAGCTATGAGGAGGTCACCTGATGATGTTCCCTTAATGACACCCAACACCATTACAATGATTCCCAACACTATAC
CAGGGATTCAGCCCTTACACACATTCAATACATTTACTGGAGGACAGAACAATACTCTGCCCCATCCCCATCCCCACCCCCATTCACATT

>57039_57039_2_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000401917_length(amino acids)=623AA_BP=14
MGENEASLPNTSLQGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQR
AIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNY
DIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVA
TADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTK
FIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFP
TAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLD

--------------------------------------------------------------
>57039_57039_3_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000457714_length(transcript)=7338nt_BP=171nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTTTCTTGA
GTACAGGCGATCAGGCTGCAAAGGGGAACTATGGACTCCTTGATCTCATACAAGCTTTAAGATGGACTAGTGAAAACATTGGATTCTTTG
GTGGTGACCCCTTAAGAATCACTGTTTTTGGATCTGGTGCTGGGGGTTCATGTGTCAACCTGCTGACTTTATCCCATTATTCTGAAGGTA
ACCGTTGGAGCAATTCAACCAAAGGACTTTTTCAACGAGCAATAGCTCAAAGTGGAACAGCCCTTTCCAGCTGGGCTGTTAGTTTTCAAC
CTGCAAAATATGCTAGAATGTTGGCCACAAAAGTTGGTTGCAATGTTTCAGATACAGTAGAGTTAGTGGAATGCCTACAGAAGAAGCCTT
ACAAAGAACTTGTTGACCAAGATATTCAACCAGCTCGATACCACATAGCCTTTGGACCTGTGATTGATGGTGATGTAATACCAGACGACC
CCCAGATATTGATGGAGCAAGGAGAGTTTCTCAACTATGATATAATGTTAGGAGTGAACCAAGGGGAAGGGTTAAAATTTGTTGAAAATA
TAGTAGATAGCGATGATGGTATATCAGCTAGTGATTTTGACTTTGCTGTTTCAAATTTTGTTGATAATTTATATGGATATCCTGAAGGCA
AAGATGTTTTGAGAGAAACCATTAAGTTCATGTATACTGACTGGGCTGACCGTCATAACCCTGAAACCAGAAGAAAGACATTACTGGCTT
TGTTTACGGACCATCAGTGGGTGGCACCAGCTGTAGCCACAGCGGATCTTCACTCAAACTTTGGTTCACCTACGTACTTCTATGCCTTTT
ACCATCATTGCCAAACAGATCAGGTTCCAGCTTGGGCTGATGCAGCCCACGGAGACGAGGTTCCCTATGTACTGGGAATCCCCATGATTG
GCCCTACAGAGTTATTTCCTTGCAATTTCTCCAAAAATGATGTGATGCTGAGTGCAGTTGTAATGACATACTGGACAAATTTTGCTAAAA
CTGGTGACCCAAATCAACCAGTCCCTCAAGACACGAAATTCATTCATACCAAACCCAACCGTTTTGAAGAAGTAGCATGGACCAGATATT
CCCAGAAAGACCAACTTTATCTCCATATTGGATTAAAACCAAGAGTTAAAGAACATTACAGAGCCAATAAGGTGAACCTCTGGTTGGAGT
TGGTACCTCATCTGCATAATCTCAATGACATTTCTCAGTATACCTCTACAACAACTAAAGTGCCATCAACTGACATCACTTTCAGACCTA
CGAGAAAAAATTCTGTACCTGTCACGTCAGCCTTTCCCACTGCCAAGCAGGATGATCCCAAACAACAACCAAGTCCATTTTCAGTGGATC
AAAGGGACTACTCAACAGAGCTGAGTGTCACTATTGCAGTTGGAGCATCACTGCTGTTTCTGAACATCTTGGCCTTTGCAGCCCTGTACT
ACAAAAAGGATAAGAGGAGACATGATGTTCACAGGAGATGCAGCCCTCAGCGCACTACTACCAATGATCTAACCCATGCACAAGAAGAGG
AAATCATGTCCCTCCAAATGAAGCACACTGATTTGGATCATGAATGTGAGTCCATTCATCCACATGAGGTGGTTCTTCGGACCGCCTGTC
CCCCAGATTACACACTAGCTATGAGGAGGTCACCTGATGATGTTCCCTTAATGACACCCAACACCATTACAATGATTCCCAACACTATAC
CAGGGATTCAGCCCTTACACACATTCAATACATTTACTGGAGGACAGAACAATACTCTGCCCCATCCCCATCCCCACCCCCATTCACATT
CAACAACCAGGGTATAGCCAGATAAGAGAAACAAACTATTTTTTTTGATGGATTGCAGTAAACGATCACTGAAGATTCCTTGGCTTTCAA
CCTACAAGACTTACTATTTAAATAAGGAGGAATATTATGTGAATATACATATCAAGAACTTTGGGGGTTTTGAAAAAAATGAATTGTATA
TATACAAATCAACTTTAAAAACAAATTTCAATTGCTTGAAGCAATTGTTCTGAATGATACTTTTTCATTCACATTCAAGAATTAATTTTT
TGAAGATTTAAGTTACATAATGGAATTAGGCATGTGGAACACCAAACAGGAAAGAACTATGTCTGAAATATAAAAAATAAAAATAAAAAA
ACAACTATGAATATGCACAAGGGACACACCAGTGGAATGTCAGATAATTTTCACCAGTTTTTATTTGGAGCCGTTTTATTGTGTAGACCA
TATTTACATATTTGGATAAGTACACAAAGCGTCAATGCTGTTAATGGCCTTAGCAAAGGCTCATGCTGAAATTTGCCAGTAAAACAAAGA
AGTTTAAAGACTGGCAGGTACACCATTATCACATAAGTGCTGTCAGTATAAAGTTGTGGGGATAAAGGAAACTGGATATTTTTAGCACGA
TGTGCATGATAATTTATATGCTTGGTGGCTGTGCTGCTGATTAAGCCGTAATTAAAATTCTTCTCATCCCATTGGAGTTTTTAATAGAAG
CTTCCTCCATCAATTGGCAGAACCTAAAGAAGATTTTAAGGGGCAAAAGTAATTACAATAAAATAATTCACAGTAGTTTCAATATAGAAG
GAATTAGCTATTAAAGGTATTTGAAGAAACTATAGGTATAGTGGTGAATACTCGCTGATATGAATCCCAGAAAAAAATTTCCTGTTTTTA
ATGTTCTTTTCAATCCCATCTAGATAATTTATAGAAATATAACCCTAATTGGACATGTGGTACAGGATCTATAAGTTGCTGTGTTTTTTT
GTTACTCTGTATTTTGTTCCTTTTGGTAAGGTGAAGTGTGTCCAAAGAGTTACTTGCAACAGTCTTTCATGATATGAGGATGCCCCCGTA
TTACCACTCTGATTATAGTTCTGAGTTCTTTGATTTACTCATGCTGCATGACAAAATGTTTACTAATAACAATTCATTATAAAGTTATAT
CCCTCTTTACATCACTTATCTTTCTCACTGAGGTTCATTCACTGGAATTTACTCACGCAATCTCAGTAGAGTACAACGTAGATACAGAAC
CTAGGAGAGTCAACATCTGGAGGATTTTAGTCTTTCTTACACATATGTGTGATTTTAAACGAATATTCTCAGACCACAGGAAACTCTTCA
TCCCCCTGTTGTTTACCAGTAACAGTATATCACAGACCTTTCCAAATGTTTGTATATGTAATCAGATGTACATTTATATTGAAAAACAAA
TGAGATGGACTTAAAGAGCACATCCTGATAAATACTTTCTCTCTCACCTGTACTATATTTCTATTAGACTAAAGTTATGTGATTTTTTTT
TTACATTTTTTCAGATGACTAGCAATTTTGATAGTTTATAAGATAATGCAAAGAACTTTCTCTGACAAACTAACTGCAGTAACAGAAACC
TTTCTTTTCAGTTACTCTTTTTCAAGAATGAAAGATTATTATACAAAAAATTGTATACTACTTGATGGAACCAACTTTGTACATCTTGGC
CATGTCACTGGTCATTGTGTGAAATAAAGATAATCTGGATAATGACTATTAGTCCAATGCTAAGAAACATGATCTTTGCTCATTAAAGAG
CTAAAATGTTTATTGCTGTTTTGTCTTTCTTTTTTCTAAAAAAAGAAAAAAAAGAAAAAAAGGAAAAGAAGAACAAAGAAACATGACTGT
CTCAAAGAGTAATTTTTCTAGATTAGACCAGTCAGGTTTTTGAAGACATATAGGTAACTTCCACAGAAAACACAAACATGTATTTAAAGG
CAAGTCTCATCTAAGATGAAACTCATAAAAATTATTTAATGTTTGTTATGAATTTAAAAGCTCCAGAAATCCATGAAAAAAAGAAAGATT
AGCTTTGTGTTGTTAAATATCTCTTAGGTACAGATGTTGTAGAAATAAAGTGCCAATTGTTTTCAGTTAGTTAGAAAAACAAGTTCCAAT
TCTAGTCATCAAGGAAAAGGTCTATTGAAAAGAAATTTGCAATATTTCATGGAATACAAATAACTAGGTTCATAAAATGGGGGTGATTAA
ACTACCATAAAGTAATGAATAGAAAGTTGCCATGCTAAGAGAATGTAAAAGTGCTGAGCAAGATATTAAACTGACACTAAAAGATAAAAA
TCTATTTCAAGGAATTTATGTGATTATAATCCCCCCTCCCAATTATTATCTATCAAAGAAATGTAGGTATTCCTCCATAATTAAAAAAAA
GTCTCTGTTAGAAGCAAAAGTCTTCAAAATCCAGAGTGATCTACATACAGCTTTTGACTGAGGTGGTTATGCTTTTCAACTGTGAACTGC
CAGTGTACACAAATACAAATAATTGTTTAGCATCTGAAGTATTGTTCAATTGGAACACTGTATTTTACTGTATTAATTAAACAAAACACA
AGAACAGAATAGAAATGACAACAAAATAAGATATGAATGAATACTTTCATATGCATTGCTTCATTTGGCAAAACCAAACATTCTATTAAA
TAGTATGTTTTAACGATGGCCATATTTATATCATCTACCTACCAATCTATTGCTCTGCATTTATCAATCTGCCTATATATAGCATAACTG
TCACCCTCTTTATATTAATTTAGGAAAATGATTGAGGAAAACAAAGCATAGCCCTATTAATTATTTTCTCTAAATTAGGGTAGAATAACT
TTATGGAAGATAAAGCAGCCTAGGTTTAATTGTTGTTCACCAGTCACGTGATAAAGTCATTGTGAATGAGTGTTAGTTGCTAGTTTTATA
ATTGCAGTCTCTAGTTTCTGAATGAAAAAGGATGCCCCACATTATACAGAACATTAAGAACTGTTTTTAAAGCTGAAACATAATCTTTAT
ATGCAAGAAAAATAAATACTGTTACTCAATTTTAGCAAATATGTTTAAAATGTATTTATTTAGATAATTTTCTTTGAAAAACAATGTAAG
TAACAAAATTAAAATAATATTTTTGGCATTATTTGTTAATTCAGATTTTCCTGCCTCCGATTAAAAATTAGGCAAAGCTGCTTATAATTT
ATACAAAGATTACACTAAAATGAACTTTATTTCATTGTTTTGCTGTTATATAAAATTTTTACCAAATGTTTACCAAGAGATTAATGTTTT
AGAGTATGAGGATAGAAAAATAAAAGTGACAGATTTCATAGTTTTAAATCTCTACTGAACATGTTGACTATGAACAAAATCTAATTGGCT
ACCACAGATATATAACAAAGTTTATTACTAACTTTATGCAAATTGGAAAATAATTTGCTAAAGCATTAAAAATGTCAGATTTGTAGACGT
CTTGCTGGCAACTCAAAGCAGAAAATCTGAGTATATATTATTTTATTCCTCATTTCAAATATAAAAGTTGACCAAAGTGATGCTTTATTT
CCGACTTCCTGATCTGTATGTGAAAACAGCAACATTTTTTTAAAAATTATCAAGTATATATAATATTAAAAAGAGGAAAACAGATGGCAC
TAATTTTCTTACAGGAGTGAAGTGCTGAAACTAAATTGTTACATCTGTAACAACAGTTATTTCACCTCTTGCCACACTCATCCTGACATA
CGTATTAATATCAAAAAATGATACAAAGAATATGAGAAATGTGTTCCAGCATTAAAGACACTACTACATAGAAATTACTGGGATTCTTTT
CTTTGGCGAGTTTCACTGAAATAGTTTCACAGGATGAAATGATGAATTGAATTCTTAAGAAGCTGTCAAATATGGCAGTCTTTTGATGTT
AGTAATTTTGTTTTCTTCTGTGTTATTGGTTCAAAGTACTGGCCTTTTCCTTCATTTCCAGTAATTAGTTGTTATAGACTATCACTTTTT
AATGTGAGTGGAAATTAGATGATTTGGTTATACTTGTGAAAACATGCTTCCAAATAAATTCAATTAATGGGCACTTCCCTGCTGAGATTT
TGTTATCATTCATTTGATTATCTTGTCAAGCTTTACTGTTACGACAAATGTTTTAGCTTTCTGGTCAATAGACTAAGGGAATTTCTCCAG
TAGCCTTATACCTCTCCTGCACTTGATCTGATAGCAACATACACTTCAAATTTCCATCAGAAGTCTCTAAAGAAATTTCCTACTGCTATG
AAACATTTGGTGGCCAACTTGATTCTTTTTCATAAGCATTCTGATTTGATTTTATTCTGGCACGTTGCTGTATTTGGATGCAGGCCAGAA
ATCAATTCCATTTGATAAGGGTTGTGGAGAATACAGACTGGAATAACCGTGTGCAGGGCTTAAGTGCCTTTTCCTCCTGAGATTTTATTT
ATAAAACTTAGCTTTTTTAAATTTTCAGATTCAGATAATTCAATTTAAAGAGTACAATAGGATGACTATATTATAAATTACCAATAAAGA
AAGTTTATTTGGACATTTTTACATTTAATTTGATTTTTAAAATAATATCAGATGCATCTAAATGGCTTCCGGGAAAGACTGAGGTAAATT
TTTGAAAGTGACAATTATATAGGCATCTGACTTGATGGTACTTAAGAATAAAAATTTAAATCTCTAGCAAACTTTAAAAATTGTCCAAAT
AGTAAGTTTAATTTGAAAGAAGTCTGAAGCTATTAGAGAAAATCATGTACTAGATAGGTATATATTTTTTTCTAGTCAGCTATTACGTAC
ACCACATAATATATATACCCTATATACTATATGGTTTATATAACATTTATAATGGCCCTTTCAGACCCATATACTTACAAATGACATTGT
ATAACTACCTACATATGTATTAATGTGACAGAATTTAGTCCTTTATGGAAAGTCAAACCAAATTGCTAGCAGTTTTGAGTTGAAATGAAT
GATAACAATTAAAGCTTTTAAGAAATTGGTAAAGGTACCGTAACAAAAACTCAGCAGATAAATTTAAAAGAGAGGGACCATTTTTGAATG
CCATTTTCAGAGTTGACATCTAAACTAGATGGTGTGTTTAAAAGGATTTTAGTGGTTTTGATTCATCCTTTCTCTGCATTCATATCATTT
AGCAAATTAATGGGACATATGTCATGGTTTTTGTAAAAAAGACCATTGGGTTGTCATGATTCAGTTTGTGTTTGGACATCTATGGCTTTC

>57039_57039_3_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000457714_length(amino acids)=622AA_BP=14
MGENEASLPNTSLQGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQR
AIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNY
DIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVA
TADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTK
FIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFP
TAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLD

--------------------------------------------------------------
>57039_57039_4_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000545397_length(transcript)=2244nt_BP=171nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTTTCTTGA
GTACAGGCGATCAGGCTGCAAAGGGGAACTATGGACTCCTTGATCTCATACAAGCTTTAAGATGGACTAGTGAAAACATTGGATTCTTTG
GTGGTGACCCCTTAAGAATCACTGTTTTTGGATCTGGTGCTGGGGGTTCATGTGTCAACCTGCTGACTTTATCCCATTATTCTGAAGGTA
ACCGTTGGAGCAATTCAACCAAAGGACTTTTTCAACGAGCAATAGCTCAAAGTGGAACAGCCCTTTCCAGCTGGGCTGTTAGTTTTCAAC
CTGCAAAATATGCTAGAATGTTGGCCACAAAAGTTGGTTGCAATGTTTCAGATACAGTAGAGTTAGTGGAATGCCTACAGAAGAAGCCTT
ACAAAGAACTTGTTGACCAAGATATTCAACCAGCTCGATACCACATAGCCTTTGGACCTGTGATTGATGGTGATGTAATACCAGACGACC
CCCAGATATTGATGGAGCAAGGAGAGTTTCTCAACTATGATATAATGTTAGGAGTGAACCAAGGGGAAGGGTTAAAATTTGTTGAAAATA
TAGTAGATAGCGATGATGGTATATCAGCTAGTGATTTTGACTTTGCTGTTTCAAATTTTGTTGATAATTTATATGGATATCCTGAAGGCA
AAGATGTTTTGAGAGAAACCATTAAGTTCATGTATACTGACTGGGCTGACCGTCATAACCCTGAAACCAGAAGAAAGACATTACTGGCTT
TGTTTACGGACCATCAGTGGGTGGCACCAGCTGTAGCCACAGCGGATCTTCACTCAAACTTTGGTTCACCTACGTACTTCTATGCCTTTT
ACCATCATTGCCAAACAGATCAGGTTCCAGCTTGGGCTGATGCAGCCCACGGAGACGAGGTTCCCTATGTACTGGGAATCCCCATGATTG
GCCCTACAGAGTTATTTCCTTGCAATTTCTCCAAAAATGATGTGATGCTGAGTGCAGTTGTAATGACATACTGGACAAATTTTGCTAAAA
CTGGTGACCCAAATCAACCAGTCCCTCAAGACACGAAATTCATTCATACCAAACCCAACCGTTTTGAAGAAGTAGCATGGACCAGATATT
CCCAGAAAGACCAACTTTATCTCCATATTGGATTAAAACCAAGAGTTAAAGAACATTACAGAGCCAATAAGGTGAACCTCTGGTTGGAGT
TGGTACCTCATCTGCATAATCTCAATGACATTTCTCAGTATACCTCTACAACAACTAAAGTGCCATCAACTGACATCACTTTCAGACCTA
CGAGAAAAAATTCTGTACCTGTCACGTCAGCCTTTCCCACTGCCAAGCAGGATGATCCCAAACAACAACCAAGTCCATTTTCAGTGGATC
AAAGGGACTACTCAACAGAGCTGAGTGTCACTATTGCAGTTGGAGCATCACTGCTGTTTCTGAACATCTTGGCCTTTGCAGCCCTGTACT
ACAAAAAGGATAAGAGGAGACATGATGTTCACAGGAGATGCAGCCCTCAGCGCACTACTACCAATGATCTAACCCATGCACAAGAAGAGG
AAATCATGTCCCTCCAAATGAAGCACACTGATTTGGATCATGAATGTGAGTCCATTCATCCACATGAGGTGGTTCTTCGGACCGCCTGTC
CCCCAGATTACACACTAGCTATGAGGAGGTCACCTGATGATGTTCCCTTAATGACACCCAACACCATTACAATGATTCCCAACACTATAC
CAGGGATTCAGCCCTTACACACATTCAATACATTTACTGGAGGACAGAACAATACTCTGCCCCATCCCCATCCCCACCCCCATTCACATT
CAACAACCAGGGTATAGCCAGATAAGAGAAACAAACTATTTTTTTTGATGGATTGCAGTAAACGATCACTGAAGATTCCTTGGCTTTCAA
CCTACAAGACTTACTATTTAAATAAGACCAACTTTGTACATCTTGGCCATGTCACTGGTCATTGTGTGAAATAAAGATAATCTGGATAAT

>57039_57039_4_NAALADL2-NLGN1_NAALADL2_chr3_174577240_ENST00000454872_NLGN1_chr3_173993105_ENST00000545397_length(amino acids)=622AA_BP=14
MGENEASLPNTSLQGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQR
AIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNY
DIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVA
TADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTK
FIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFP
TAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NAALADL2-NLGN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAALADL2-NLGN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAALADL2-NLGN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource