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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAALADL2-ROBO2 (FusionGDB2 ID:57044)

Fusion Gene Summary for NAALADL2-ROBO2

check button Fusion gene summary
Fusion gene informationFusion gene name: NAALADL2-ROBO2
Fusion gene ID: 57044
HgeneTgene
Gene symbol

NAALADL2

ROBO2

Gene ID

254827

6092

Gene nameN-acetylated alpha-linked acidic dipeptidase like 2roundabout guidance receptor 2
Synonyms-SAX3
Cytomap

3q26.31

3p12.3

Type of geneprotein-codingprotein-coding
Descriptioninactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologueroundabout homolog 2roundabout, axon guidance receptor, homolog 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000473253, ENST00000454872, 
ENST00000332191, ENST00000461745, 
ENST00000487694, ENST00000469233, 
Fusion gene scores* DoF score28 X 19 X 9=478818 X 21 X 7=2646
# samples 2922
** MAII scorelog2(29/4788*10)=-4.04529834692857
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2646*10)=-3.58823763275402
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAALADL2 [Title/Abstract] AND ROBO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAALADL2(175042114)-ROBO2(77526565), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROBO2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

TgeneROBO2

GO:0050772

positive regulation of axonogenesis

12504588

TgeneROBO2

GO:0050925

negative regulation of negative chemotaxis

11748139


check buttonFusion gene breakpoints across NAALADL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ROBO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6363NAALADL2chr3

175042114

+ROBO2chr3

77526565

+


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Fusion Gene ORF analysis for NAALADL2-ROBO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000473253ENST00000332191NAALADL2chr3

175042114

+ROBO2chr3

77526565

+
3UTR-3CDSENST00000473253ENST00000461745NAALADL2chr3

175042114

+ROBO2chr3

77526565

+
3UTR-3CDSENST00000473253ENST00000487694NAALADL2chr3

175042114

+ROBO2chr3

77526565

+
3UTR-intronENST00000473253ENST00000469233NAALADL2chr3

175042114

+ROBO2chr3

77526565

+
5CDS-intronENST00000454872ENST00000469233NAALADL2chr3

175042114

+ROBO2chr3

77526565

+
In-frameENST00000454872ENST00000332191NAALADL2chr3

175042114

+ROBO2chr3

77526565

+
In-frameENST00000454872ENST00000461745NAALADL2chr3

175042114

+ROBO2chr3

77526565

+
In-frameENST00000454872ENST00000487694NAALADL2chr3

175042114

+ROBO2chr3

77526565

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000454872NAALADL2chr3175042114+ENST00000487694ROBO2chr377526565+6422121812849661612
ENST00000454872NAALADL2chr3175042114+ENST00000461745ROBO2chr377526565+8876121812849661612
ENST00000454872NAALADL2chr3175042114+ENST00000332191ROBO2chr377526565+6211121812851491673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000454872ENST00000487694NAALADL2chr3175042114+ROBO2chr377526565+0.0002927370.9997073
ENST00000454872ENST00000461745NAALADL2chr3175042114+ROBO2chr377526565+0.0001694320.9998305
ENST00000454872ENST00000332191NAALADL2chr3175042114+ROBO2chr377526565+0.000309690.9996903

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Fusion Genomic Features for NAALADL2-ROBO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NAALADL2chr3175042114+ROBO2chr377526564+2.15E-050.99997854
NAALADL2chr3175042114+ROBO2chr377526564+2.15E-050.99997854

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NAALADL2-ROBO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:175042114/chr3:77526565)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAALADL2chr3:175042114chr3:77526565ENST00000454872+5141_121363796.0Topological domainCytoplasmic
HgeneNAALADL2chr3:175042114chr3:77526565ENST00000454872+514122_142363796.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126133_2201291379.0DomainNote=Ig-like C2-type 2
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126225_3091291379.0DomainNote=Ig-like C2-type 3
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126314_4091291379.0DomainNote=Ig-like C2-type 4
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126418_5041291379.0DomainNote=Ig-like C2-type 5
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126524_6181291379.0DomainFibronectin type-III 1
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126637_7351291379.0DomainFibronectin type-III 2
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126739_8361291379.0DomainFibronectin type-III 3
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227225_3091451395.0DomainNote=Ig-like C2-type 3
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227314_4091451395.0DomainNote=Ig-like C2-type 4
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227418_5041451395.0DomainNote=Ig-like C2-type 5
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227524_6181451395.0DomainFibronectin type-III 1
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227637_7351451395.0DomainFibronectin type-III 2
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227739_8361451395.0DomainFibronectin type-III 3
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126881_13781291379.0Topological domainCytoplasmic
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227881_13781451395.0Topological domainCytoplasmic
TgeneROBO2chr3:175042114chr3:77526565ENST00000461745126860_8801291379.0TransmembraneHelical
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227860_8801451395.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAALADL2chr3:175042114chr3:77526565ENST00000454872+514143_795363796.0Topological domainExtracellular
TgeneROBO2chr3:175042114chr3:77526565ENST0000046174512631_1271291379.0DomainNote=Ig-like C2-type 1
TgeneROBO2chr3:175042114chr3:77526565ENST00000487694227133_2201451395.0DomainNote=Ig-like C2-type 2
TgeneROBO2chr3:175042114chr3:77526565ENST0000048769422731_1271451395.0DomainNote=Ig-like C2-type 1
TgeneROBO2chr3:175042114chr3:77526565ENST0000046174512622_8591291379.0Topological domainExtracellular
TgeneROBO2chr3:175042114chr3:77526565ENST0000048769422722_8591451395.0Topological domainExtracellular


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Fusion Gene Sequence for NAALADL2-ROBO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57044_57044_1_NAALADL2-ROBO2_NAALADL2_chr3_175042114_ENST00000454872_ROBO2_chr3_77526565_ENST00000332191_length(transcript)=6211nt_BP=1218nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGA
TGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCAGGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACT
TAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGTTTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAG
AGACTATAGACCTCAATCTTGATTCCATTCAACCAGCAACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTA
CCCATTATACACGATCTGCACCAAAGAGCAATCGCTGCAACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTT
TTGGGATTTTGATAGGTTATTATGTACATACAAATTGCCCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGA
TTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCTTTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAA
AGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTC
CCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAG
ACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAA
AAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGG
AAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGT
CACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGTGTTACGAGATGACTTCCGACAAAACCCCACAGATGTTGTAG
TGGCAGCTGGAGAGCCTGCAATCCTGGAGTGCCAGCCTCCCCGGGGACACCCAGAACCCACCATCTACTGGAAAAAAGACAAAGTTCGAA
TTGATGACAAGGAAGAAAGAATAAGTATCCGTGGTGGAAAACTGATGATCTCCAATACCAGGAAAAGTGATGCAGGGATGTATACTTGTG
TTGGTACCAATATGGTGGGAGAAAGGGACAGTGACCCAGCAGAGCTGACTGTCTTTGAACGACCCACATTTCTCAGGAGGCCAATTAACC
AGGTGGTACTGGAGGAAGAAGCTGTAGAATTTCGTTGTCAAGTCCAAGGAGATCCTCAACCAACTGTGAGGTGGAAAAAGGATGATGCAG
ACTTGCCAAGAGGAAGGTATGACATCAAAGACGATTACACACTAAGAATTAAAAAGACCATGAGTACAGATGAAGGCACCTATATGTGTA
TTGCTGAGAATCGGGTTGGAAAAATGGAAGCCTCTGCTACACTCACCGTCCGAGCTCCCCCACAGTTTGTGGTTCGGCCAAGAGATCAGA
TTGTTGCTCAAGGTCGAACAGTGACATTTCCCTGTGAAACTAAAGGAAACCCACAGCCAGCTGTTTTTTGGCAGAAAGAAGGCAGCCAGA
ACCTACTTTTCCCAAACCAACCCCAGCAGCCCAACAGTAGATGCTCAGTGTCACCAACTGGAGACCTCACAATCACCAACATTCAACGTT
CCGACGCGGGTTACTACATCTGCCAGGCTTTAACTGTGGCAGGAAGCATTTTAGCAAAAGCTCAACTGGAGGTTACTGATGTTTTGACAG
ATAGACCTCCACCTATAATTCTACAAGGCCCAGCCAACCAAACGCTGGCAGTGGATGGTACAGCGTTACTGAAATGTAAAGCCACTGGTG
ATCCTCTTCCTGTAATTAGCTGGTTAAAGGAGGGATTTACTTTTCCGGGTAGAGATCCAAGAGCAACAATTCAAGAGCAAGGCACACTGC
AGATTAAGAATTTACGGATTTCTGATACTGGCACTTATACTTGTGTGGCTACAAGTTCAAGTGGAGAGACTTCCTGGAGTGCAGTGCTGG
ATGTGACAGAGTCTGGAGCAACAATCAGTAAAAACTATGATTTAAGTGACCTGCCAGGGCCACCATCCAAACCGCAGGTCACTGATGTTA
CTAAGAACAGTGTCACCTTGTCCTGGCAGCCAGGTACCCCTGGAACCCTTCCAGCAAGTGCATATATCATTGAGGCTTTCAGCCAATCAG
TGAGCAACAGCTGGCAGACCGTGGCAAACCATGTAAAGACCACCCTCTATACTGTAAGAGGACTGCGGCCCAATACAATCTACTTATTCA
TGGTCAGAGCGATCAACCCCCAAGGTCTCAGTGACCCAAGTCCCATGTCAGATCCTGTGCGCACACAAGATATCAGCCCACCAGCACAAG
GAGTGGACCACAGGCAAGTGCAGAAAGAGCTAGGAGATGTCCTTGTCCGTCTTCATAATCCAGTTGTGCTGACTCCCACCACGGTTCAGG
TCACATGGACGGTTGATCGCCAACCCCAGTTTATCCAAGGCTACCGAGTGATGTATCGTCAGACTTCAGGTCTGCAGGCGACATCTTCGT
GGCAGAATTTAGATGCCAAAGTCCCGACTGAACGAAGTGCTGTCTTAGTCAACCTGAAAAAGGGGGTGACTTATGAAATTAAAGTACGGC
CATATTTTAATGAGTTCCAAGGAATGGATAGTGAATCTAAAACGGTTCGTACTACTGAAGAAGCCCCAAGTGCCCCACCACAGTCTGTCA
CTGTACTGACAGTTGGAAGCTACAATAGCACAAGTATTAGTGTTTCCTGGGATCCTCCTCCTCCAGATCACCAGAATGGAATTATCCAAG
AATACAAGATCTGGTGTCTAGGAAATGAAACGCGATTCCATATCAACAAAACTGTGGATGCAGCCATTCGGTCCGTAATAATTGGTGGAT
TATTCCCAGGTATTCAATACCGGGTAGAGGTTGCAGCTAGTACCAGTGCAGGGGTTGGAGTAAAGAGTGAGCCACAGCCAATAATAATCG
GGAGACGCAATGAAGTTGTCATTACTGAAAACAATAACAGCATAACTGAGCAAATCACTGATGTGGTGAAGCAACCAGCCTTTATAGCTG
GTATTGGTGGTGCCTGCTGGGTAATTCTGATGGGTTTTAGCATATGGTTGTATTGGCGAAGAAAGAAGAGGAAGGGACTCAGTAATTATG
CTGTTACGTTTCAAAGAGGAGATGGAGGACTAATGAGCAATGGAAGCCGTCCAGGTCTTCTCAATGCTGGTGATCCCAGCTATCCATGGC
TTGCTGATTCTTGGCCAGCCACGAGCTTGCCAGTAAATAATAGCAACAGTGGCCCAAATGAGATTGGAAATTTTGGCCGTGGAGATGTGC
TGCCACCAGTTCCAGGCCAAGGGGATAAAACAGCAACGATGCTCTCAGATGGAGCCATTTATAGTAGCATTGACTTCACTACCAAAACCA
GTTACAACAGTTCCAGCCAAATAACACAGGCTACCCCATATGCCACGACACAGATCTTGCATTCCAACAGCATACATGAATTGGCTGTCG
ATCTGCCTGATCCACAATGGAAAAGCTCAATTCAGCAAAAAACAGATCTGATGGGATTTGGTTATTCTCTACCTGATCAGAACAAAGGTA
ACAATGGTGGGAAAGGTGGAAAAAAGAAGAAAAATAAAAACTCTTCTAAACCACAGAAAAACAATGGATCCACTTGGGCCAATGTCCCTC
TACCTCCCCCCCCAGTCCAGCCCCTTCCTGGCACGGAGCTGGAACACTATGCAGTGGAACAACAAGAAAATGGCTATGACAGTGATAGCT
GGTGCCCACCATTGCCAGTACAAACTTACTTACACCAAGGTCTGGAAGATGAACTGGAAGAAGATGATGATAGGGTCCCAACACCTCCTG
TTCGAGGCGTGGCTTCTTCTCCTGCTATCTCCTTTGGACAGCAGTCCACTGCAACTCTTACTCCATCCCCACGGGAAGAGATGCAACCCA
TGCTGCAGGCTCACCTGGATGAGTTGACAAGAGCCTATCAGTTTGATATAGCAAAACAAACATGGCACATTCAAAGCAATAATCAACCTC
CACAGCCTCCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACG
AAGAGGAAGCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAG
GTTCAATGGTAAATGGATGGGGCTCTGCATCTGATGAGGATCGTAACTTTTCTAGTCATAGATCTAGTGTAGGTAGCTCCTCAGATGGCT
CTATCTTTGCCAGCGGCAGTTTTGCACAAGCACTGGTGGCAGCAGCAGATAAAGCTGGTTTTAGGCTGGATGGAACCAGCCTTACAAGAA
CAGGAAAAGCCTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTC
AGAGGCCTCGGCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGG
AGGCCTTGGTGCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGAC
CTAGGAAAACCGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGAC
AGTTTACAGGTGAATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCT
AAACAGTGCAATGAACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATAT
TTTCATTGTGTTCTTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCT
ACAGGAAGAAAAGGATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTC
TGTTCTTATTGGTCTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATT
TTGCACTGCAATTTTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACT
GTAAGCTAGATTGGATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAAT
GGTGTTGGCAAAGTCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGG
TCAAAAAAAGTAGTTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATT
AAAGTTTTATTTAGAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAA
GAGCTGTATTTATATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAA
GTTCCCCAAGGAAACGAACAAAATGAACTCTAGAATATCTAGCAAATAGTTAAAGAAGCAATTTATTATTAGGGCATACTCGGGCTGTTT

>57044_57044_1_NAALADL2-ROBO2_NAALADL2_chr3_175042114_ENST00000454872_ROBO2_chr3_77526565_ENST00000332191_length(amino acids)=1673AA_BP=359
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVVLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP
AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA
TLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTV
AGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTY
TCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVK
TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQ
GYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI
SVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNN
SITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVN
NSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQ
KTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQ
GLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSG
ALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIFASGSFAQALV
AAADKAGFRLDGTSLTRTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPS

--------------------------------------------------------------
>57044_57044_2_NAALADL2-ROBO2_NAALADL2_chr3_175042114_ENST00000454872_ROBO2_chr3_77526565_ENST00000461745_length(transcript)=8876nt_BP=1218nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGA
TGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCAGGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACT
TAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGTTTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAG
AGACTATAGACCTCAATCTTGATTCCATTCAACCAGCAACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTA
CCCATTATACACGATCTGCACCAAAGAGCAATCGCTGCAACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTT
TTGGGATTTTGATAGGTTATTATGTACATACAAATTGCCCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGA
TTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCTTTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAA
AGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTC
CCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAG
ACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAA
AAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGG
AAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGT
CACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGTGTTACGAGATGACTTCCGACAAAACCCCACAGATGTTGTAG
TGGCAGCTGGAGAGCCTGCAATCCTGGAGTGCCAGCCTCCCCGGGGACACCCAGAACCCACCATCTACTGGAAAAAAGACAAAGTTCGAA
TTGATGACAAGGAAGAAAGAATAAGTATCCGTGGTGGAAAACTGATGATCTCCAATACCAGGAAAAGTGATGCAGGGATGTATACTTGTG
TTGGTACCAATATGGTGGGAGAAAGGGACAGTGACCCAGCAGAGCTGACTGTCTTTGAACGACCCACATTTCTCAGGAGGCCAATTAACC
AGGTGGTACTGGAGGAAGAAGCTGTAGAATTTCGTTGTCAAGTCCAAGGAGATCCTCAACCAACTGTGAGGTGGAAAAAGGATGATGCAG
ACTTGCCAAGAGGAAGGTATGACATCAAAGACGATTACACACTAAGAATTAAAAAGACCATGAGTACAGATGAAGGCACCTATATGTGTA
TTGCTGAGAATCGGGTTGGAAAAATGGAAGCCTCTGCTACACTCACCGTCCGAGCTCCCCCACAGTTTGTGGTTCGGCCAAGAGATCAGA
TTGTTGCTCAAGGTCGAACAGTGACATTTCCCTGTGAAACTAAAGGAAACCCACAGCCAGCTGTTTTTTGGCAGAAAGAAGGCAGCCAGA
ACCTACTTTTCCCAAACCAACCCCAGCAGCCCAACAGTAGATGCTCAGTGTCACCAACTGGAGACCTCACAATCACCAACATTCAACGTT
CCGACGCGGGTTACTACATCTGCCAGGCTTTAACTGTGGCAGGAAGCATTTTAGCAAAAGCTCAACTGGAGGTTACTGATGTTTTGACAG
ATAGACCTCCACCTATAATTCTACAAGGCCCAGCCAACCAAACGCTGGCAGTGGATGGTACAGCGTTACTGAAATGTAAAGCCACTGGTG
ATCCTCTTCCTGTAATTAGCTGGTTAAAGGAGGGATTTACTTTTCCGGGTAGAGATCCAAGAGCAACAATTCAAGAGCAAGGCACACTGC
AGATTAAGAATTTACGGATTTCTGATACTGGCACTTATACTTGTGTGGCTACAAGTTCAAGTGGAGAGACTTCCTGGAGTGCAGTGCTGG
ATGTGACAGAGTCTGGAGCAACAATCAGTAAAAACTATGATTTAAGTGACCTGCCAGGGCCACCATCCAAACCGCAGGTCACTGATGTTA
CTAAGAACAGTGTCACCTTGTCCTGGCAGCCAGGTACCCCTGGAACCCTTCCAGCAAGTGCATATATCATTGAGGCTTTCAGCCAATCAG
TGAGCAACAGCTGGCAGACCGTGGCAAACCATGTAAAGACCACCCTCTATACTGTAAGAGGACTGCGGCCCAATACAATCTACTTATTCA
TGGTCAGAGCGATCAACCCCCAAGGTCTCAGTGACCCAAGTCCCATGTCAGATCCTGTGCGCACACAAGATATCAGCCCACCAGCACAAG
GAGTGGACCACAGGCAAGTGCAGAAAGAGCTAGGAGATGTCCTTGTCCGTCTTCATAATCCAGTTGTGCTGACTCCCACCACGGTTCAGG
TCACATGGACGGTTGATCGCCAACCCCAGTTTATCCAAGGCTACCGAGTGATGTATCGTCAGACTTCAGGTCTGCAGGCGACATCTTCGT
GGCAGAATTTAGATGCCAAAGTCCCGACTGAACGAAGTGCTGTCTTAGTCAACCTGAAAAAGGGGGTGACTTATGAAATTAAAGTACGGC
CATATTTTAATGAGTTCCAAGGAATGGATAGTGAATCTAAAACGGTTCGTACTACTGAAGAAGCCCCAAGTGCCCCACCACAGTCTGTCA
CTGTACTGACAGTTGGAAGCTACAATAGCACAAGTATTAGTGTTTCCTGGGATCCTCCTCCTCCAGATCACCAGAATGGAATTATCCAAG
AATACAAGATCTGGTGTCTAGGAAATGAAACGCGATTCCATATCAACAAAACTGTGGATGCAGCCATTCGGTCCGTAATAATTGGTGGAT
TATTCCCAGGTATTCAATACCGGGTAGAGGTTGCAGCTAGTACCAGTGCAGGGGTTGGAGTAAAGAGTGAGCCACAGCCAATAATAATCG
GGAGACGCAATGAAGTTGTCATTACTGAAAACAATAACAGCATAACTGAGCAAATCACTGATGTGGTGAAGCAACCAGCCTTTATAGCTG
GTATTGGTGGTGCCTGCTGGGTAATTCTGATGGGTTTTAGCATATGGTTGTATTGGCGAAGAAAGAAGAGGAAGGGACTCAGTAATTATG
CTGTTACGTTTCAAAGAGGAGATGGAGGACTAATGAGCAATGGAAGCCGTCCAGGTCTTCTCAATGCTGGTGATCCCAGCTATCCATGGC
TTGCTGATTCTTGGCCAGCCACGAGCTTGCCAGTAAATAATAGCAACAGTGGCCCAAATGAGATTGGAAATTTTGGCCGTGGAGATGTGC
TGCCACCAGTTCCAGGCCAAGGGGATAAAACAGCAACGATGCTCTCAGATGGAGCCATTTATAGTAGCATTGACTTCACTACCAAAACCA
GTTACAACAGTTCCAGCCAAATAACACAGGCTACCCCATATGCCACGACACAGATCTTGCATTCCAACAGCATACATGAATTGGCTGTCG
ATCTGCCTGATCCACAATGGAAAAGCTCAATTCAGCAAAAAACAGATCTGATGGGATTTGGTTATTCTCTACCTGATCAGAACAAAGGTA
ACAATGGTGGGAAAGGTGGAAAAAAGAAGAAAAATAAAAACTCTTCTAAACCACAGAAAAACAATGGATCCACTTGGGCCAATGTCCCTC
TACCTCCCCCCCCAGTCCAGCCCCTTCCTGGCACGGAGCTGGAACACTATGCAGTGGAACAACAAGAAAATGGCTATGACAGTGATAGCT
GGTGCCCACCATTGCCAGTACAAACTTACTTACACCAAGGTCTGGAAGATGAACTGGAAGAAGATGATGATAGGGTCCCAACACCTCCTG
TTCGAGGCGTGGCTTCTTCTCCTGCTATCTCCTTTGGACAGCAGTCCACTGCAACTCTTACTCCATCCCCACGGGAAGAGATGCAACCCA
TGCTGCAGGCTCACCTGGATGAGTTGACAAGAGCCTATCAGTTTGATATAGCAAAACAAACATGGCACATTCAAAGCAATAATCAACCTC
CACAGCCTCCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACG
AAGAGGAAGCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAG
GAAAAGCCTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGA
GGCCTCGGCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGG
CCTTGGTGCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTA
GGAAAACCGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGT
TTACAGGTGAATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAAA
CAGTGCAATGAACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTTT
CATTGTGTTCTTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTACA
GGAAGAAAAGGATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTGT
TCTTATTGGTCTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTTG
CACTGCAATTTTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGTA
AGCTAGATTGGATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGGT
GTTGGCAAAGTCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTCA
AAAAAAGTAGTTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAAA
GTTTTATTTAGAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGAG
CTGTATTTATATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGTT
CCCCAAGGAAACGAACAAAATGAACTCTAGAATATCTAGCAAATAGTTAAAGAAGCAATTTATTATTAGGGCATACTCGGGCTGTTTCCA
AATATAAACTCTATTGCAATATCTTATTTCATCTTTCTAATACATGTACAGTGCACACTAGAGGATAGAGCTGCATCACTTAAATTCATG
ACTTAAAAAATAATACAGTTTATATACAACTTGTTTTTTATTTGATTAAGAAGTGAAGTTTACGCCACCCAATGTATAGCCAAATTGTAC
GTGCTTAAAAAACAGTGCCGAGAGTATGTTCAGTTCGCAGTAAGTAGATTTATTGGAATAAATATTCTATGGTACATTCTCAGAAATTGG
CTTCCAACTAAAATACGTTTGACCCATTTTGAATAAGGAAATTGAAAAGAAAAATTTAAAAGGAGAAAAAAATGCATGTTTATAAACTTT
TTAAATAAAACCAGACCTTGTAAGTGGACATTAATAATTGTCCTGCCTCATTTGTTTTCACGACTTTGACAACAAGAAGTTCCTGAACAT
TAGTCATGTATGCTCAGAATAAATGTGACTTTGAAATATATGTTAGCTACTGTACATGTATAGTCAGTCAAGTAGAAGAGGACCTTCCTG
AAATTCCCACTTGTGACATTTTCCCATGGGTTTCCTACACAATCTTAAATTTTATTTCTGTCTATACTTTCTCAAATTTTTCCTATGATA
AGTTCAGTTGTTGGTACTCTTCTAAAAATATTCAACGTGATTAGGATCAGTTCTAAAATACGGGACCCCTTTGAGTGACAATTCGCACTC
CATGCATTATTGGCTCAGTAGCCAATTTTTGTCACGTCGTTATAACAAGGAGATGACATAATTAAACATTTCCATCCTTTCTATTCCCTG
AGACTGCATCAGCACAGGCAAGTATAGAATGTAATGTTCTTCATGGGCCCCACCAGCTTTTTGGTGCCATGTAATTTATTTCTTCGCTGA
AGAGAAAAAGAATTCTGAGACACAGTTATTAAACCCTTTATCAACTTTCTACCATCAGTGCCTGAATTCTAATGCAGTGTGATTTCTCTG
GGACAAAGAGACTGAGGAAGATGAAAAGTTTCTTCAAAGAGTGAATACATACTTATTCACAACTCTAGGATGTGAGGACTTTAAATATCT
CTTTATGAAGTTCCCTGCCTAACCTCTTTCTATTTAAAGGCAAACAAATTTCGAAGAGGTTTTGTGTTCCCTCTTTATGTTTCTCTATGA
CCCAGTTTAGTCTAAAACCTTAGTTCATTACATATACAACACATAGCCTTTGATCCCTGGTAACTGGCAGGTGTTGGTGATTAATAAACC
AAGGCTTCAAAGTGAAGTATGTGTGTGCAGATGACTTTTGGAATAACGTGGGCATAGCATCATACCTTCCTGATTGTCTTCAGCATATAA
AAATTAACTGTTGTAGTTAAAATTATGTCAGTGCAGAGCTTGTGGTTACTTGGAATGTTCTTTCAGAATAGTCCATGTTGCCTATTAAAC
CTAGTTTTAAACACATTGGGCAGTCAATTTATGCACCCAAAATATCACCCTCAGGTAGATTGAGGGCAAGATAAAATGCTGTATGTAGCT
ATACAAAGGAATTCAGAAACATTACTGGAAAGCAAAGCCTTTGTCAGCTTGCTACTGACAAAGTAGTAAAAAGCTACTAATCAGTGTTGA
GTCAGATGTCAACAGAAAAATACAAATACCTATGAGAGCCACAGCAGTTTCTCGTTTCATAGCCGATTCAATGAATATGATTAGAAATTC
ACTGAGCTCACTCTTGCAGGTTTAAATGGAGGCCTGCATAAGGACTGCAAGAGGAAATCTGGGTGGGAGAGAATGTAATCTGATCTTGCA
CTCATAGGCAATGCTGCAATGCAATCATGTCCAATACAAGCACAGCTTCATTCATAACAGGAAACGTCTTCTTTGGGAAAATAGCTCTAT
TGGTGCCCAAACTCAGGTATGCCAGTGTATGCAGGTGGAGTCGCCCTACCCCTCTTCCAAACATGTCCTGTGAGATTTTTAAAATAAGAT
GGGATAGTACAGGGGCATGAAAAGAATTGATTCCTTCACAGGATTTGAATCCAGTTCAAGGGAGAATGTAGAAAATTCAAAACCAACATA
TAAGGTATCACACAACCAAGAAAAGTAAAACCATTGCAAGTTTACTTGCGTTGAGTACAAAACAGATTTAATGGTGTTCTATGTCATAGT
TTAATGCTCTGGGTATTTAAATATGTTTTCAACAGGATTTGAGTTGAAAGTTTGTAATGTGCTTTGATGGAACACCTCTCAATTTCTATT
CAATAAACTTATGTAATTGTCCATTGACAATATAATGATAACAGTACCATTGAACTCTAAACTGTGGTTTATCTTCACTACTGGGAAGCA
ACTGTGCATCAGTATTAAAGATATGCAGAAACATAATATTCACTAATTTGTTCATCTGCTTCTGTATATTGTTTATGGAATTACATGGCA
AGAACTGTTCTAAAGCAACATGTCTTTCCACATTATTTTAGAGGTGAAATTACTTTTGTTTTGCTTCTCTATAATGTGTACTTCAAATGA
AACACCATACTTTTTTCTAAAAAAAGATGTTCAATTTACTAATTTTTTTAAATCTCATAATTTAAAAAGCATTTGTTGTGATTTTAAAGT
GTTGCAAGAAAAGGGATTTTGTGGCCGTGGGTAGACTTTTTATACTTTGTTTTATAGATGGATTTTTTTTAACTGTAGTTTGTTTAAGTC
ACCAAGCAGCATCCAAAATCTTAATGTGTTTCATTTGATGTTGTTAGATCAGAGAAGAAATTGGCATAAAATCGGTTAATAGTATTGTCA

>57044_57044_2_NAALADL2-ROBO2_NAALADL2_chr3_175042114_ENST00000454872_ROBO2_chr3_77526565_ENST00000461745_length(amino acids)=1612AA_BP=359
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVVLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP
AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA
TLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTV
AGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTY
TCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVK
TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQ
GYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI
SVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNN
SITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVN
NSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQ
KTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQ
GLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSG
ALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRM

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>57044_57044_3_NAALADL2-ROBO2_NAALADL2_chr3_175042114_ENST00000454872_ROBO2_chr3_77526565_ENST00000487694_length(transcript)=6422nt_BP=1218nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGA
TGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCAGGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACT
TAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGTTTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAG
AGACTATAGACCTCAATCTTGATTCCATTCAACCAGCAACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTA
CCCATTATACACGATCTGCACCAAAGAGCAATCGCTGCAACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTT
TTGGGATTTTGATAGGTTATTATGTACATACAAATTGCCCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGA
TTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCTTTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAA
AGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTC
CCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAG
ACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAA
AAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGG
AAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGT
CACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGTGTTACGAGATGACTTCCGACAAAACCCCACAGATGTTGTAG
TGGCAGCTGGAGAGCCTGCAATCCTGGAGTGCCAGCCTCCCCGGGGACACCCAGAACCCACCATCTACTGGAAAAAAGACAAAGTTCGAA
TTGATGACAAGGAAGAAAGAATAAGTATCCGTGGTGGAAAACTGATGATCTCCAATACCAGGAAAAGTGATGCAGGGATGTATACTTGTG
TTGGTACCAATATGGTGGGAGAAAGGGACAGTGACCCAGCAGAGCTGACTGTCTTTGAACGACCCACATTTCTCAGGAGGCCAATTAACC
AGGTGGTACTGGAGGAAGAAGCTGTAGAATTTCGTTGTCAAGTCCAAGGAGATCCTCAACCAACTGTGAGGTGGAAAAAGGATGATGCAG
ACTTGCCAAGAGGAAGGTATGACATCAAAGACGATTACACACTAAGAATTAAAAAGACCATGAGTACAGATGAAGGCACCTATATGTGTA
TTGCTGAGAATCGGGTTGGAAAAATGGAAGCCTCTGCTACACTCACCGTCCGAGCTCCCCCACAGTTTGTGGTTCGGCCAAGAGATCAGA
TTGTTGCTCAAGGTCGAACAGTGACATTTCCCTGTGAAACTAAAGGAAACCCACAGCCAGCTGTTTTTTGGCAGAAAGAAGGCAGCCAGA
ACCTACTTTTCCCAAACCAACCCCAGCAGCCCAACAGTAGATGCTCAGTGTCACCAACTGGAGACCTCACAATCACCAACATTCAACGTT
CCGACGCGGGTTACTACATCTGCCAGGCTTTAACTGTGGCAGGAAGCATTTTAGCAAAAGCTCAACTGGAGGTTACTGATGTTTTGACAG
ATAGACCTCCACCTATAATTCTACAAGGCCCAGCCAACCAAACGCTGGCAGTGGATGGTACAGCGTTACTGAAATGTAAAGCCACTGGTG
ATCCTCTTCCTGTAATTAGCTGGTTAAAGGAGGGATTTACTTTTCCGGGTAGAGATCCAAGAGCAACAATTCAAGAGCAAGGCACACTGC
AGATTAAGAATTTACGGATTTCTGATACTGGCACTTATACTTGTGTGGCTACAAGTTCAAGTGGAGAGACTTCCTGGAGTGCAGTGCTGG
ATGTGACAGAGTCTGGAGCAACAATCAGTAAAAACTATGATTTAAGTGACCTGCCAGGGCCACCATCCAAACCGCAGGTCACTGATGTTA
CTAAGAACAGTGTCACCTTGTCCTGGCAGCCAGGTACCCCTGGAACCCTTCCAGCAAGTGCATATATCATTGAGGCTTTCAGCCAATCAG
TGAGCAACAGCTGGCAGACCGTGGCAAACCATGTAAAGACCACCCTCTATACTGTAAGAGGACTGCGGCCCAATACAATCTACTTATTCA
TGGTCAGAGCGATCAACCCCCAAGGTCTCAGTGACCCAAGTCCCATGTCAGATCCTGTGCGCACACAAGATATCAGCCCACCAGCACAAG
GAGTGGACCACAGGCAAGTGCAGAAAGAGCTAGGAGATGTCCTTGTCCGTCTTCATAATCCAGTTGTGCTGACTCCCACCACGGTTCAGG
TCACATGGACGGTTGATCGCCAACCCCAGTTTATCCAAGGCTACCGAGTGATGTATCGTCAGACTTCAGGTCTGCAGGCGACATCTTCGT
GGCAGAATTTAGATGCCAAAGTCCCGACTGAACGAAGTGCTGTCTTAGTCAACCTGAAAAAGGGGGTGACTTATGAAATTAAAGTACGGC
CATATTTTAATGAGTTCCAAGGAATGGATAGTGAATCTAAAACGGTTCGTACTACTGAAGAAGCCCCAAGTGCCCCACCACAGTCTGTCA
CTGTACTGACAGTTGGAAGCTACAATAGCACAAGTATTAGTGTTTCCTGGGATCCTCCTCCTCCAGATCACCAGAATGGAATTATCCAAG
AATACAAGATCTGGTGTCTAGGAAATGAAACGCGATTCCATATCAACAAAACTGTGGATGCAGCCATTCGGTCCGTAATAATTGGTGGAT
TATTCCCAGGTATTCAATACCGGGTAGAGGTTGCAGCTAGTACCAGTGCAGGGGTTGGAGTAAAGAGTGAGCCACAGCCAATAATAATCG
GGAGACGCAATGAAGTTGTCATTACTGAAAACAATAACAGCATAACTGAGCAAATCACTGATGTGGTGAAGCAACCAGCCTTTATAGCTG
GTATTGGTGGTGCCTGCTGGGTAATTCTGATGGGTTTTAGCATATGGTTGTATTGGCGAAGAAAGAAGAGGAAGGGACTCAGTAATTATG
CTGTTACGTTTCAAAGAGGAGATGGAGGACTAATGAGCAATGGAAGCCGTCCAGGTCTTCTCAATGCTGGTGATCCCAGCTATCCATGGC
TTGCTGATTCTTGGCCAGCCACGAGCTTGCCAGTAAATAATAGCAACAGTGGCCCAAATGAGATTGGAAATTTTGGCCGTGGAGATGTGC
TGCCACCAGTTCCAGGCCAAGGGGATAAAACAGCAACGATGCTCTCAGATGGAGCCATTTATAGTAGCATTGACTTCACTACCAAAACCA
GTTACAACAGTTCCAGCCAAATAACACAGGCTACCCCATATGCCACGACACAGATCTTGCATTCCAACAGCATACATGAATTGGCTGTCG
ATCTGCCTGATCCACAATGGAAAAGCTCAATTCAGCAAAAAACAGATCTGATGGGATTTGGTTATTCTCTACCTGATCAGAACAAAGGTA
ACAATGGTGGGAAAGGTGGAAAAAAGAAGAAAAATAAAAACTCTTCTAAACCACAGAAAAACAATGGATCCACTTGGGCCAATGTCCCTC
TACCTCCCCCCCCAGTCCAGCCCCTTCCTGGCACGGAGCTGGAACACTATGCAGTGGAACAACAAGAAAATGGCTATGACAGTGATAGCT
GGTGCCCACCATTGCCAGTACAAACTTACTTACACCAAGGTCTGGAAGATGAACTGGAAGAAGATGATGATAGGGTCCCAACACCTCCTG
TTCGAGGCGTGGCTTCTTCTCCTGCTATCTCCTTTGGACAGCAGTCCACTGCAACTCTTACTCCATCCCCACGGGAAGAGATGCAACCCA
TGCTGCAGGCTCACCTGGATGAGTTGACAAGAGCCTATCAGTTTGATATAGCAAAACAAACATGGCACATTCAAAGCAATAATCAACCTC
CACAGCCTCCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACG
AAGAGGAAGCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAG
GAAAAGCCTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGA
GGCCTCGGCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGG
CCTTGGTGCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTA
GGAAAACCGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGT
TTACAGGTGAATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAAA
CAGTGCAATGAACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTTT
CATTGTGTTCTTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTACA
GGAAGAAAAGGATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTGT
TCTTATTGGTCTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTTG
CACTGCAATTTTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGTA
AGCTAGATTGGATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGGT
GTTGGCAAAGTCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTCA
AAAAAAGTAGTTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAAA
GTTTTATTTAGAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGAG
CTGTATTTATATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGTT
CCCCAAGGAAACGAACAAAATGAACTCTAGAATATCTAGCAAATAGTTAAAGAAGCAATTTATTATTAGGGCATACTCGGGCTGTTTCCA
AATATAAACTCTATTGCAATATCTTATTTCATCTTTCTAATACATGTACAGTGCACACTAGAGGATAGAGCTGCATCACTTAAATTCATG
ACTTAAAAAATAATACAGTTTATATACAACTTGTTTTTTATTTGATTAAGAAGTGAAGTTTACGCCACCCAATGTATAGCCAAATTGTAC
GTGCTTAAAAAACAGTGCCGAGAGTATGTTCAGTTCGCAGTAAGTAGATTTATTGGAATAAATATTCTATGGTACATTCTCAGAAATTGG
CTTCCAACTAAAATACGTTTGACCCATTTTGAATAAGGAAATTGAAAAGAAAAATTTAAAAGGAGAAAAAAATGCATGTTTATAAACTTT

>57044_57044_3_NAALADL2-ROBO2_NAALADL2_chr3_175042114_ENST00000454872_ROBO2_chr3_77526565_ENST00000487694_length(amino acids)=1612AA_BP=359
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVVLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP
AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA
TLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTV
AGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTY
TCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVK
TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQ
GYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI
SVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNN
SITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVN
NSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQ
KTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQ
GLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSG
ALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRM

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Fusion Gene PPI Analysis for NAALADL2-ROBO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAALADL2-ROBO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAALADL2-ROBO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource