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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAB2-STAT6 (FusionGDB2 ID:57062)

Fusion Gene Summary for NAB2-STAT6

check button Fusion gene summary
Fusion gene informationFusion gene name: NAB2-STAT6
Fusion gene ID: 57062
HgeneTgene
Gene symbol

NAB2

STAT6

Gene ID

4665

6778

Gene nameNGFI-A binding protein 2signal transducer and activator of transcription 6
SynonymsMADERD12S1644|IL-4-STAT|STAT6B|STAT6C
Cytomap

12q13.3

12q13.3

Type of geneprotein-codingprotein-coding
DescriptionNGFI-A-binding protein 2EGR1 binding protein 2melanoma-associated delayed early response proteinsignal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STAT
Modification date2020032920200329
UniProtAcc

Q15742

P42226

Ensembl transtripts involved in fusion geneENST00000357680, ENST00000300131, 
ENST00000342556, ENST00000554718, 
ENST00000300134, ENST00000454075, 
ENST00000537215, ENST00000538913, 
ENST00000543873, ENST00000556155, 
Fusion gene scores* DoF score2 X 9 X 3=5442 X 21 X 17=14994
# samples 446
** MAII scorelog2(4/54*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(46/14994*10)=-5.02660763586348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAB2 [Title/Abstract] AND STAT6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTAT6(57489142)-NAB2(57489138), # samples:4
NAB2(57487381)-STAT6(57493223), # samples:2
Anticipated loss of major functional domain due to fusion event.NAB2-STAT6 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NAB2-STAT6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NAB2-STAT6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NAB2-STAT6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NAB2-STAT6 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
STAT6-NAB2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
STAT6-NAB2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
STAT6-NAB2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
STAT6-NAB2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
STAT6-NAB2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAB2

GO:0016480

negative regulation of transcription by RNA polymerase III

8668170

TgeneSTAT6

GO:0045944

positive regulation of transcription by RNA polymerase II

8810328


check buttonFusion gene breakpoints across NAB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STAT6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-SH-A7BH-01ANAB2chr12

57487381

-STAT6chr12

57493223

-
ChimerDB4MESOTCGA-SH-A7BH-01ANAB2chr12

57487381

+STAT6chr12

57493223

-
ChimerKB3..NAB2chr12

57485781

+STAT6chr12

57500363

-
ChimerKB3..NAB2chr12

57485781

+STAT6chr12

57500614

-
ChimerKB3..NAB2chr12

57485781

+STAT6chr12

57502082

-
ChimerKB3..NAB2chr12

57486364

+STAT6chr12

57490916

-
ChimerKB3..NAB2chr12

57486364

+STAT6chr12

57492380

-
ChimerKB3..NAB2chr12

57486364

+STAT6chr12

57492685

-
ChimerKB3..NAB2chr12

57486364

+STAT6chr12

57492861

-
ChimerKB3..NAB2chr12

57486364

+STAT6chr12

57502082

-
ChimerKB3..NAB2chr12

57486751

+STAT6chr12

57492685

-
ChimerKB3..NAB2chr12

57486751

+STAT6chr12

57501097

-
ChimerKB3..NAB2chr12

57486751

+STAT6chr12

57501526

-
ChimerKB3..NAB2chr12

57486751

+STAT6chr12

57502082

-
ChimerKB3..NAB2chr12

57486751

+STAT6chr12

57505196

-
ChimerKB3..NAB2chr12

57486978

+STAT6chr12

57492685

-
ChimerKB3..NAB2chr12

57486978

+STAT6chr12

57492861

-
ChimerKB3..NAB2chr12

57486978

+STAT6chr12

57493223

-
ChimerKB3..NAB2chr12

57486978

+STAT6chr12

57502082

-
ChimerKB3..NAB2chr12

57486978

+STAT6chr12

57505196

-
ChimerKB3..NAB2chr12

57487381

+STAT6chr12

57492685

-
ChimerKB3..NAB2chr12

57487381

+STAT6chr12

57492861

-
ChimerKB3..NAB2chr12

57487381

+STAT6chr12

57493223

-
ChimerKB3..NAB2chr12

57487381

+STAT6chr12

57493686

-
ChimerKB3..NAB2chr12

57487381

+STAT6chr12

57502082

-
ChimerKB3..NAB2chr12

57489259

+STAT6chr12

57490916

-
ChimerKB3..NAB2chr12

57489259

+STAT6chr12

57492685

-
ChimerKB3..NAB2chr12

57489259

+STAT6chr12

57492861

-
ChimerKB3..NAB2chr12

57489259

+STAT6chr12

57493223

-
ChimerKB3..NAB2chr12

57489259

+STAT6chr12

57502082

-
ChimerKB4..NAB2chr12

57486699

+STAT6chr12

57486699

-
ChiTaRS5.0N/ABF337329NAB2chr12

57489013

+STAT6chr12

57489015

+


Top

Fusion Gene ORF analysis for NAB2-STAT6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57487381

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57486751

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57486751

+STAT6chr12

57501097

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57486751

+STAT6chr12

57501526

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57486978

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57486978

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57486978

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57487381

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57487381

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000300134NAB2chr12

57487381

+STAT6chr12

57493686

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57487381

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57486751

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57486978

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57486978

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57486978

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57487381

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57487381

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000454075NAB2chr12

57487381

+STAT6chr12

57493686

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57487381

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57486751

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57486978

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57486978

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57486978

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57487381

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57487381

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000537215NAB2chr12

57487381

+STAT6chr12

57493686

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57487381

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57486751

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57486978

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57486978

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57486978

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57487381

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57487381

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000538913NAB2chr12

57487381

+STAT6chr12

57493686

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57487381

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57486751

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57486978

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57486978

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57486978

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57487381

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57487381

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000543873NAB2chr12

57487381

+STAT6chr12

57493686

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57487381

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57486751

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57486978

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57486978

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57486978

+STAT6chr12

57493223

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57487381

+STAT6chr12

57492685

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57487381

+STAT6chr12

57492861

-
3UTR-3CDSENST00000357680ENST00000556155NAB2chr12

57487381

+STAT6chr12

57493686

-
3UTR-5UTRENST00000357680ENST00000300134NAB2chr12

57486751

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000300134NAB2chr12

57486751

+STAT6chr12

57505196

-
3UTR-5UTRENST00000357680ENST00000300134NAB2chr12

57486978

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000300134NAB2chr12

57486978

+STAT6chr12

57505196

-
3UTR-5UTRENST00000357680ENST00000300134NAB2chr12

57487381

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000454075NAB2chr12

57486751

+STAT6chr12

57501097

-
3UTR-5UTRENST00000357680ENST00000454075NAB2chr12

57486751

+STAT6chr12

57501526

-
3UTR-5UTRENST00000357680ENST00000454075NAB2chr12

57486751

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000454075NAB2chr12

57486978

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000454075NAB2chr12

57487381

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000537215NAB2chr12

57486751

+STAT6chr12

57501097

-
3UTR-5UTRENST00000357680ENST00000537215NAB2chr12

57486751

+STAT6chr12

57501526

-
3UTR-5UTRENST00000357680ENST00000538913NAB2chr12

57486751

+STAT6chr12

57501097

-
3UTR-5UTRENST00000357680ENST00000543873NAB2chr12

57486751

+STAT6chr12

57501097

-
3UTR-5UTRENST00000357680ENST00000543873NAB2chr12

57486751

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000543873NAB2chr12

57486978

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000543873NAB2chr12

57487381

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000556155NAB2chr12

57486751

+STAT6chr12

57501097

-
3UTR-5UTRENST00000357680ENST00000556155NAB2chr12

57486751

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000556155NAB2chr12

57486978

+STAT6chr12

57502082

-
3UTR-5UTRENST00000357680ENST00000556155NAB2chr12

57487381

+STAT6chr12

57502082

-
3UTR-intronENST00000300131ENST00000300134NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000300131ENST00000454075NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000300131ENST00000537215NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000300131ENST00000538913NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000300131ENST00000543873NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000300131ENST00000556155NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000342556ENST00000300134NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000342556ENST00000454075NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000342556ENST00000537215NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000342556ENST00000538913NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000342556ENST00000543873NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000342556ENST00000556155NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000357680ENST00000300134NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000357680ENST00000454075NAB2chr12

57486751

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000454075NAB2chr12

57486978

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000454075NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000357680ENST00000537215NAB2chr12

57486751

+STAT6chr12

57502082

-
3UTR-intronENST00000357680ENST00000537215NAB2chr12

57486751

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000537215NAB2chr12

57486978

+STAT6chr12

57502082

-
3UTR-intronENST00000357680ENST00000537215NAB2chr12

57486978

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000537215NAB2chr12

57487381

+STAT6chr12

57502082

-
3UTR-intronENST00000357680ENST00000537215NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000357680ENST00000538913NAB2chr12

57486751

+STAT6chr12

57501526

-
3UTR-intronENST00000357680ENST00000538913NAB2chr12

57486751

+STAT6chr12

57502082

-
3UTR-intronENST00000357680ENST00000538913NAB2chr12

57486751

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000538913NAB2chr12

57486978

+STAT6chr12

57502082

-
3UTR-intronENST00000357680ENST00000538913NAB2chr12

57486978

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000538913NAB2chr12

57487381

+STAT6chr12

57502082

-
3UTR-intronENST00000357680ENST00000538913NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000357680ENST00000543873NAB2chr12

57486751

+STAT6chr12

57501526

-
3UTR-intronENST00000357680ENST00000543873NAB2chr12

57486751

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000543873NAB2chr12

57486978

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000543873NAB2chr12

57489013

+STAT6chr12

57489015

+
3UTR-intronENST00000357680ENST00000556155NAB2chr12

57486751

+STAT6chr12

57501526

-
3UTR-intronENST00000357680ENST00000556155NAB2chr12

57486751

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000556155NAB2chr12

57486978

+STAT6chr12

57505196

-
3UTR-intronENST00000357680ENST00000556155NAB2chr12

57489013

+STAT6chr12

57489015

+
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57485781

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57486364

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57486751

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57486751

+STAT6chr12

57505196

-
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57486978

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57486978

+STAT6chr12

57505196

-
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57487381

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000300134NAB2chr12

57489259

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57485781

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57486364

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57486751

+STAT6chr12

57501097

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57486751

+STAT6chr12

57501526

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57486751

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57486978

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57487381

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000454075NAB2chr12

57489259

+STAT6chr12

57502082

-
5CDS-5UTRENST00000300131ENST00000537215NAB2chr12

57486751

+STAT6chr12

57501097

-
5CDS-5UTRENST00000300131ENST00000537215NAB2chr12

57486751

+STAT6chr12

57501526

-
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57486699

-
intron-intronENST00000554718ENST00000300134NAB2chr12

57486699

+STAT6chr12

57486699

-
intron-intronENST00000554718ENST00000300134NAB2chr12

57489013

+STAT6chr12

57489015

+
intron-intronENST00000554718ENST00000454075NAB2chr12

57486751

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000454075NAB2chr12

57486978

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000454075NAB2chr12

57486699

+STAT6chr12

57486699

-
intron-intronENST00000554718ENST00000454075NAB2chr12

57489013

+STAT6chr12

57489015

+
intron-intronENST00000554718ENST00000537215NAB2chr12

57485781

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57486364

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57486751

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57486751

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57486978

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57486978

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57487381

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57489259

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57486699

+STAT6chr12

57486699

-
intron-intronENST00000554718ENST00000537215NAB2chr12

57489013

+STAT6chr12

57489015

+
intron-intronENST00000554718ENST00000538913NAB2chr12

57485781

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57486364

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57486751

+STAT6chr12

57501526

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57486751

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57486751

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57486978

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57486978

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57487381

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57489259

+STAT6chr12

57502082

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57486699

+STAT6chr12

57486699

-
intron-intronENST00000554718ENST00000538913NAB2chr12

57489013

+STAT6chr12

57489015

+
intron-intronENST00000554718ENST00000543873NAB2chr12

57486751

+STAT6chr12

57501526

-
intron-intronENST00000554718ENST00000543873NAB2chr12

57486751

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000543873NAB2chr12

57486978

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000543873NAB2chr12

57486699

+STAT6chr12

57486699

-
intron-intronENST00000554718ENST00000543873NAB2chr12

57489013

+STAT6chr12

57489015

+
intron-intronENST00000554718ENST00000556155NAB2chr12

57486751

+STAT6chr12

57501526

-
intron-intronENST00000554718ENST00000556155NAB2chr12

57486751

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000556155NAB2chr12

57486978

+STAT6chr12

57505196

-
intron-intronENST00000554718ENST00000556155NAB2chr12

57486699

+STAT6chr12

57486699

-
intron-intronENST00000554718ENST00000556155NAB2chr12

57489013

+STAT6chr12

57489015

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NAB2-STAT6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAB2-STAT6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57489142/chr12:57489138)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAB2

Q15742

STAT6

P42226

FUNCTION: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAB2chr12:57487381chr12:57493223ENST00000300131+67267_356489526.0RegionNote=NCD2
HgeneNAB2chr12:57487381chr12:57493223ENST00000300131+67353_384489526.0RegionNecessary for nuclear localization
HgeneNAB2chr12:57487381chr12:57493223ENST00000300131+6735_113489526.0RegionNote=NCD1
HgeneNAB2chr12:57487381chr12:57493223ENST00000357680+56267_356444328.0RegionNote=NCD2
HgeneNAB2chr12:57487381chr12:57493223ENST00000357680+56353_384444328.0RegionNecessary for nuclear localization
HgeneNAB2chr12:57487381chr12:57493223ENST00000357680+5635_113444328.0RegionNote=NCD1
TgeneSTAT6chr12:57487381chr12:57493223ENST000005372151321517_632471738.0DomainSH2
TgeneSTAT6chr12:57487381chr12:57493223ENST000005389131220517_632471738.0DomainSH2
TgeneSTAT6chr12:57487381chr12:57493223ENST000003001341422802_806581848.0MotifNote=LXXLL motif
TgeneSTAT6chr12:57487381chr12:57493223ENST000004540751422802_806581848.0MotifNote=LXXLL motif
TgeneSTAT6chr12:57487381chr12:57493223ENST000005372151321802_806471738.0MotifNote=LXXLL motif
TgeneSTAT6chr12:57487381chr12:57493223ENST000005389131220802_806471738.0MotifNote=LXXLL motif
TgeneSTAT6chr12:57487381chr12:57493223ENST000005438731422802_806581848.0MotifNote=LXXLL motif
TgeneSTAT6chr12:57487381chr12:57493223ENST000005561551422802_806581848.0MotifNote=LXXLL motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAB2chr12:57487381chr12:57493223ENST00000342556+16267_3560462.0RegionNote=NCD2
HgeneNAB2chr12:57487381chr12:57493223ENST00000342556+16353_3840462.0RegionNecessary for nuclear localization
HgeneNAB2chr12:57487381chr12:57493223ENST00000342556+1635_1130462.0RegionNote=NCD1
TgeneSTAT6chr12:57487381chr12:57493223ENST000003001341422517_632581848.0DomainSH2
TgeneSTAT6chr12:57487381chr12:57493223ENST000004540751422517_632581848.0DomainSH2
TgeneSTAT6chr12:57487381chr12:57493223ENST000005438731422517_632581848.0DomainSH2
TgeneSTAT6chr12:57487381chr12:57493223ENST000005561551422517_632581848.0DomainSH2


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Fusion Gene Sequence for NAB2-STAT6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NAB2-STAT6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAB2-STAT6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAB2-STAT6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource