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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAMPT-CEP290 (FusionGDB2 ID:57162)

Fusion Gene Summary for NAMPT-CEP290

check button Fusion gene summary
Fusion gene informationFusion gene name: NAMPT-CEP290
Fusion gene ID: 57162
HgeneTgene
Gene symbol

NAMPT

CEP290

Gene ID

10135

80184

Gene namenicotinamide phosphoribosyltransferasecentrosomal protein 290
Synonyms1110035O14Rik|PBEF|PBEF1|VF|VISFATIN3H11Ag|BBS14|CT87|JBTS5|LCA10|MKS4|NPHP6|POC3|SLSN6|rd16
Cytomap

7q22.3

12q21.32

Type of geneprotein-codingprotein-coding
Descriptionnicotinamide phosphoribosyltransferaseNAmPRTasepre-B cell-enhancing factorpre-B-cell colony-enhancing factor 1centrosomal protein of 290 kDaBardet-Biedl syndrome 14 proteinCTCL tumor antigen se2-2Meckel syndrome, type 4POC3 centriolar protein homologcancer/testis antigen 87centrosomal protein 290kDamonoclonal antibody 3H11 antigennephrocytsin-6prostate c
Modification date2020032220200328
UniProtAcc

P43490

O15078

Ensembl transtripts involved in fusion geneENST00000484527, ENST00000222553, 
ENST00000354289, 		ENST00000309041, 
ENST00000397838, ENST00000547691, 
ENST00000552810, 
Fusion gene scores* DoF score6 X 6 X 3=1089 X 9 X 6=486
# samples 69
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAMPT [Title/Abstract] AND CEP290 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAMPT(105915391)-CEP290(88452797), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAMPT

GO:0008286

insulin receptor signaling pathway

17983582

HgeneNAMPT

GO:0045944

positive regulation of transcription by RNA polymerase II

23001182

HgeneNAMPT

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

19727662

HgeneNAMPT

GO:0060612

adipose tissue development

17983582

TgeneCEP290

GO:0045893

positive regulation of transcription, DNA-templated

16682973

TgeneCEP290

GO:0060271

cilium assembly

26386044


check buttonFusion gene breakpoints across NAMPT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP290 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EWNAMPTchr7

105915391

-CEP290chr12

88452797

-


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Fusion Gene ORF analysis for NAMPT-CEP290

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000484527ENST00000309041NAMPTchr7

105915391

-CEP290chr12

88452797

-
5UTR-3CDSENST00000484527ENST00000397838NAMPTchr7

105915391

-CEP290chr12

88452797

-
5UTR-3CDSENST00000484527ENST00000547691NAMPTchr7

105915391

-CEP290chr12

88452797

-
5UTR-3CDSENST00000484527ENST00000552810NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000222553ENST00000309041NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000222553ENST00000397838NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000222553ENST00000547691NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000222553ENST00000552810NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000354289ENST00000309041NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000354289ENST00000397838NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000354289ENST00000547691NAMPTchr7

105915391

-CEP290chr12

88452797

-
In-frameENST00000354289ENST00000552810NAMPTchr7

105915391

-CEP290chr12

88452797

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222553NAMPTchr7105915391-ENST00000547691CEP290chr1288452797-15896263081420370
ENST00000222553NAMPTchr7105915391-ENST00000552810CEP290chr1288452797-15856263081420370
ENST00000222553NAMPTchr7105915391-ENST00000397838CEP290chr1288452797-14216263081420371
ENST00000222553NAMPTchr7105915391-ENST00000309041CEP290chr1288452797-14216263081420371
ENST00000354289NAMPTchr7105915391-ENST00000547691CEP290chr1288452797-1318355371149370
ENST00000354289NAMPTchr7105915391-ENST00000552810CEP290chr1288452797-1314355371149370
ENST00000354289NAMPTchr7105915391-ENST00000397838CEP290chr1288452797-1150355371149371
ENST00000354289NAMPTchr7105915391-ENST00000309041CEP290chr1288452797-1150355371149371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222553ENST00000547691NAMPTchr7105915391-CEP290chr1288452797-0.0003611180.9996389
ENST00000222553ENST00000552810NAMPTchr7105915391-CEP290chr1288452797-0.0003682760.99963176
ENST00000222553ENST00000397838NAMPTchr7105915391-CEP290chr1288452797-0.000679250.99932075
ENST00000222553ENST00000309041NAMPTchr7105915391-CEP290chr1288452797-0.000679250.99932075
ENST00000354289ENST00000547691NAMPTchr7105915391-CEP290chr1288452797-0.0005225110.99947757
ENST00000354289ENST00000552810NAMPTchr7105915391-CEP290chr1288452797-0.0005301930.9994698
ENST00000354289ENST00000397838NAMPTchr7105915391-CEP290chr1288452797-0.0010251280.9989749
ENST00000354289ENST00000309041NAMPTchr7105915391-CEP290chr1288452797-0.0010251280.9989749

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Fusion Genomic Features for NAMPT-CEP290


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAMPT-CEP290


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:105915391/chr12:88452797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAMPT

P43490

CEP290

O15078

FUNCTION: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.FUNCTION: Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEP290chr7:105915391chr12:88452797ENST0000039783839461533_158412751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000039783839461635_245212751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000054769122291533_158412751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000054769122291635_245212751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000039783839461966_247912751540.0RegionSelf-association (with itself or N-terminus)
TgeneCEP290chr7:105915391chr12:88452797ENST0000054769122291966_247912751540.0RegionSelf-association (with itself or N-terminus)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAMPTchr7:105915391chr12:88452797ENST00000222553-311311_313106492.0RegionNote=Nicotinamide ribonucleotide binding
HgeneNAMPTchr7:105915391chr12:88452797ENST00000222553-311353_354106492.0RegionNote=Nicotinamide ribonucleotide binding
HgeneNAMPTchr7:105915391chr12:88452797ENST00000354289-38311_313106369.0RegionNote=Nicotinamide ribonucleotide binding
HgeneNAMPTchr7:105915391chr12:88452797ENST00000354289-38353_354106369.0RegionNote=Nicotinamide ribonucleotide binding
TgeneCEP290chr7:105915391chr12:88452797ENST0000039783839461071_149812751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000003978383946598_66412751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST00000397838394659_56512751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000003978383946697_93112751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000003978383946958_102712751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000054769122291071_149812751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000005476912229598_66412751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST00000547691222959_56512751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000005476912229697_93112751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000005476912229958_102712751540.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000055281047541071_149822152480.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000055281047541533_158422152480.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000055281047541635_245222152480.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000005528104754598_66422152480.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST00000552810475459_56522152480.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000005528104754697_93122152480.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST000005528104754958_102722152480.0Coiled coilOntology_term=ECO:0000255
TgeneCEP290chr7:105915391chr12:88452797ENST0000039783839461_69512751540.0RegionSelf-association (with itself or C-terminus)
TgeneCEP290chr7:105915391chr12:88452797ENST0000054769122291_69512751540.0RegionSelf-association (with itself or C-terminus)
TgeneCEP290chr7:105915391chr12:88452797ENST0000055281047541966_247922152480.0RegionSelf-association (with itself or N-terminus)
TgeneCEP290chr7:105915391chr12:88452797ENST0000055281047541_69522152480.0RegionSelf-association (with itself or C-terminus)


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Fusion Gene Sequence for NAMPT-CEP290


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57162_57162_1_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000309041_length(transcript)=1421nt_BP=626nt
GCTGCCGCGCCCCGCCCTTTCTCGGCCCCCGGAGGGTGACGGGGTGAAGGCGGGGGAACCGAGGTGGGGAGTCCGCCAGAGCTCCCAGAC
TGCGAGCACGCGAGCCGCCGCAGCCGTCACCCGCGCCGCGTCACGGCTCCCGGGCCCGCCCTCCTCTGACCCCTCCCCTCTCTCCGTTTC
CCCCTCTCCCCCTCCTCCGCCGACCGAGCAGTGACTTAAGCAACGGAGCGCGGTGAAGCTCATTTTTCTCCTTCCTCGCAGCCGCGCCAG
GGAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCT
ACAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCA
AATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAG
AGAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAA
CTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGA
GATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAA
CCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAG
AACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCC
TTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGG
ACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATC
TAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATC
TTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAA

>57162_57162_1_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000309041_length(amino acids)=371AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------
>57162_57162_2_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000397838_length(transcript)=1421nt_BP=626nt
GCTGCCGCGCCCCGCCCTTTCTCGGCCCCCGGAGGGTGACGGGGTGAAGGCGGGGGAACCGAGGTGGGGAGTCCGCCAGAGCTCCCAGAC
TGCGAGCACGCGAGCCGCCGCAGCCGTCACCCGCGCCGCGTCACGGCTCCCGGGCCCGCCCTCCTCTGACCCCTCCCCTCTCTCCGTTTC
CCCCTCTCCCCCTCCTCCGCCGACCGAGCAGTGACTTAAGCAACGGAGCGCGGTGAAGCTCATTTTTCTCCTTCCTCGCAGCCGCGCCAG
GGAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCT
ACAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCA
AATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAG
AGAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAA
CTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGA
GATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAA
CCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAG
AACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCC
TTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGG
ACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATC
TAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATC
TTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAA

>57162_57162_2_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000397838_length(amino acids)=371AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------
>57162_57162_3_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000547691_length(transcript)=1589nt_BP=626nt
GCTGCCGCGCCCCGCCCTTTCTCGGCCCCCGGAGGGTGACGGGGTGAAGGCGGGGGAACCGAGGTGGGGAGTCCGCCAGAGCTCCCAGAC
TGCGAGCACGCGAGCCGCCGCAGCCGTCACCCGCGCCGCGTCACGGCTCCCGGGCCCGCCCTCCTCTGACCCCTCCCCTCTCTCCGTTTC
CCCCTCTCCCCCTCCTCCGCCGACCGAGCAGTGACTTAAGCAACGGAGCGCGGTGAAGCTCATTTTTCTCCTTCCTCGCAGCCGCGCCAG
GGAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCT
ACAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCA
AATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAG
AGAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAA
CTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGA
GATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAA
CCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAG
AACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCC
TTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGG
ACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATC
TAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATC
TTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAA
CTAGCCCTGTTGCTGCTTCTGAAGAGTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCACCTATAAACTTTG
TTTCATTTAACTATTTATTAACTTTATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCTTCTCACTACCTTG

>57162_57162_3_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000547691_length(amino acids)=370AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------
>57162_57162_4_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000552810_length(transcript)=1585nt_BP=626nt
GCTGCCGCGCCCCGCCCTTTCTCGGCCCCCGGAGGGTGACGGGGTGAAGGCGGGGGAACCGAGGTGGGGAGTCCGCCAGAGCTCCCAGAC
TGCGAGCACGCGAGCCGCCGCAGCCGTCACCCGCGCCGCGTCACGGCTCCCGGGCCCGCCCTCCTCTGACCCCTCCCCTCTCTCCGTTTC
CCCCTCTCCCCCTCCTCCGCCGACCGAGCAGTGACTTAAGCAACGGAGCGCGGTGAAGCTCATTTTTCTCCTTCCTCGCAGCCGCGCCAG
GGAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCT
ACAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCA
AATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAG
AGAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAA
CTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGA
GATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAA
CCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAG
AACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCC
TTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGG
ACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATC
TAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATC
TTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAA
CTAGCCCTGTTGCTGCTTCTGAAGAGTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCACCTATAAACTTTG
TTTCATTTAACTATTTATTAACTTTATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCTTCTCACTACCTTG

>57162_57162_4_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000222553_CEP290_chr12_88452797_ENST00000552810_length(amino acids)=370AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------
>57162_57162_5_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000309041_length(transcript)=1150nt_BP=355nt
GAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCTA
CAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCAA
ATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAGA
GAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAAC
TGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAG
ATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAAC
CAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGA
ACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCT
TAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGA
CCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCT
AGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCT
TAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAAC

>57162_57162_5_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000309041_length(amino acids)=371AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------
>57162_57162_6_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000397838_length(transcript)=1150nt_BP=355nt
GAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCTA
CAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCAA
ATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAGA
GAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAAC
TGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAG
ATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAAC
CAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGA
ACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCT
TAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGA
CCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCT
AGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCT
TAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAAC

>57162_57162_6_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000397838_length(amino acids)=371AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------
>57162_57162_7_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000547691_length(transcript)=1318nt_BP=355nt
GAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCTA
CAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCAA
ATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAGA
GAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAAC
TGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAG
ATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAAC
CAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGA
ACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCT
TAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGA
CCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCT
AGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCT
TAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAAC
TAGCCCTGTTGCTGCTTCTGAAGAGTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCACCTATAAACTTTGT
TTCATTTAACTATTTATTAACTTTATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCTTCTCACTACCTTGT

>57162_57162_7_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000547691_length(amino acids)=370AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------
>57162_57162_8_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000552810_length(transcript)=1314nt_BP=355nt
GAGCTCGCGGCGCGCGGCCCCTGTCCTCCGGCCCGAGATGAATCCTGCGGCAGAAGCCGAGTTCAACATCCTCCTGGCCACCGACTCCTA
CAAGGTTACTCACTATAAACAATATCCACCCAACACAAGCAAAGTTTATTCCTACTTTGAATGCCGTGAAAAGAAGACAGAAAACTCCAA
ATTAAGGAAGGTGAAATATGAGGAAACAGTATTTTATGGGTTGCAGTACATTCTTAATAAGTACTTAAAAGGTAAAGTAGTAACCAAAGA
GAAAATCCAGGAAGCCAAAGATGTCTACAAAGAACATTTCCAAGATGATGTCTTTAATGAAAAGGGATGGAACTACATTCTTGAGGAAAC
TGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAG
ATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAAC
CAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGA
ACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCT
TAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGA
CCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCT
AGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCT
TAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAAC
TAGCCCTGTTGCTGCTTCTGAAGAGTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCACCTATAAACTTTGT
TTCATTTAACTATTTATTAACTTTATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCTTCTCACTACCTTGT

>57162_57162_8_NAMPT-CEP290_NAMPT_chr7_105915391_ENST00000354289_CEP290_chr12_88452797_ENST00000552810_length(amino acids)=370AA_BP=106
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEH
FQDDVFNEKGWNYILEETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK
NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD
QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NAMPT-CEP290


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCEP290chr7:105915391chr12:88452797ENST000003978383946696_8961275.01540.0IQCB1
TgeneCEP290chr7:105915391chr12:88452797ENST000005476912229696_8961275.01540.0IQCB1
TgeneCEP290chr7:105915391chr12:88452797ENST000005528104754696_8962215.02480.0IQCB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAMPT-CEP290


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAMPT-CEP290


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource