FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NAP1L1-DNM1L (FusionGDB2 ID:57176)

Fusion Gene Summary for NAP1L1-DNM1L

check button Fusion gene summary
Fusion gene informationFusion gene name: NAP1L1-DNM1L
Fusion gene ID: 57176
HgeneTgene
Gene symbol

NAP1L1

DNM1L

Gene ID

4673

10059

Gene namenucleosome assembly protein 1 like 1dynamin 1 like
SynonymsNAP1|NAP1L|NRPDLP1|DRP1|DVLP|DYMPLE|EMPF|EMPF1|HDYNIV|OPA5
Cytomap

12q21.2

12p11.21

Type of geneprotein-codingprotein-coding
Descriptionnucleosome assembly protein 1-like 1HSP22-like protein interacting proteinNAP-1-related proteindynamin-1-like proteinDnm1p/Vps1p-like proteindynamin family member proline-rich carboxyl-terminal domain lessdynamin-like protein 4dynamin-like protein IVdynamin-related protein 1
Modification date2020032220200327
UniProtAcc

P55209

O00429

Ensembl transtripts involved in fusion geneENST00000261182, ENST00000393263, 
ENST00000431879, ENST00000535020, 
ENST00000542344, ENST00000544816, 
ENST00000547773, ENST00000547993, 
ENST00000548044, ENST00000549596, 
ENST00000552342, 		ENST00000266481, 
ENST00000358214, ENST00000381000, 
ENST00000414834, ENST00000452533, 
ENST00000547312, ENST00000548671, 
ENST00000549701, ENST00000553257, 
Fusion gene scores* DoF score17 X 16 X 4=108810 X 9 X 8=720
# samples 2413
** MAII scorelog2(24/1088*10)=-2.18057224564182
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAP1L1 [Title/Abstract] AND DNM1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAP1L1(76444434)-DNM1L(32878185), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNM1L

GO:0000266

mitochondrial fission

23530241

TgeneDNM1L

GO:0003374

dynamin family protein polymerization involved in mitochondrial fission

11514614|23530241

TgeneDNM1L

GO:0016559

peroxisome fission

12618434

TgeneDNM1L

GO:0050714

positive regulation of protein secretion

9570752

TgeneDNM1L

GO:0061025

membrane fusion

20850011

TgeneDNM1L

GO:0065003

protein-containing complex assembly

20850011

TgeneDNM1L

GO:0090149

mitochondrial membrane fission

11514614


check buttonFusion gene breakpoints across NAP1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DNM1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACF134903NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+


Top

Fusion Gene ORF analysis for NAP1L1-DNM1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000261182ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000261182ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000393263ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000431879ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000535020ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000542344ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000544816ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547773ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000547993ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000548044ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000549596ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000266481NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000358214NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000381000NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000414834NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000452533NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000547312NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000548671NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000549701NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+
intron-intronENST00000552342ENST00000553257NAP1L1chr12

76444434

+DNM1Lchr12

32878185

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for NAP1L1-DNM1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NAP1L1-DNM1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76444434/:32878185)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAP1L1

P55209

DNM1L

O00429

FUNCTION: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:26841755). Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). {ECO:0000250|UniProtKB:P28656, ECO:0000269|PubMed:20002496, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:26841755, ECO:0000269|PubMed:28369616}.; FUNCTION: (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression. {ECO:0000269|PubMed:23691099}.; FUNCTION: (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA. {ECO:0000269|PubMed:27599637}.FUNCTION: Functions in mitochondrial and peroxisomal division (PubMed:9570752, PubMed:9786947, PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17553808, PubMed:17460227, PubMed:18695047, PubMed:18838687, PubMed:19638400, PubMed:19411255, PubMed:19342591, PubMed:23921378, PubMed:23283981, PubMed:23530241, PubMed:29478834, PubMed:32484300, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23921378, PubMed:23283981, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:9570752, PubMed:20688057, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for NAP1L1-DNM1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for NAP1L1-DNM1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NAP1L1-DNM1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NAP1L1-DNM1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource