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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APTX-ARL5B (FusionGDB2 ID:5719)

Fusion Gene Summary for APTX-ARL5B

check button Fusion gene summary
Fusion gene informationFusion gene name: APTX-ARL5B
Fusion gene ID: 5719
HgeneTgene
Gene symbol

APTX

ARL5B

Gene ID

54840

221079

Gene nameaprataxinADP ribosylation factor like GTPase 5B
SynonymsAOA|AOA1|AXA1|EAOH|EOAHA|FHA-HITARL8
Cytomap

9p21.1

10p12.31

Type of geneprotein-codingprotein-coding
Descriptionaprataxinforkhead-associated domain histidine triad-like proteinADP-ribosylation factor-like protein 5BADP-ribosylation factor-like 5BADP-ribosylation factor-like 8ADP-ribosylation factor-like protein 8ADP-ribosylation-like factor 8
Modification date2020032020200313
UniProtAcc

Q7Z2E3

Q96KC2

Ensembl transtripts involved in fusion geneENST00000397172, ENST00000309615, 
ENST00000379813, ENST00000379817, 
ENST00000379819, ENST00000379825, 
ENST00000436040, ENST00000463596, 
ENST00000468275, ENST00000473270, 
ENST00000476858, 		ENST00000377275, 
Fusion gene scores* DoF score10 X 9 X 6=5405 X 5 X 3=75
# samples 126
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APTX [Title/Abstract] AND ARL5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPTX(32987758)-ARL5B(18961551), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPTX

GO:0000012

single strand break repair

17519253

HgeneAPTX

GO:0042542

response to hydrogen peroxide

15044383


check buttonFusion gene breakpoints across APTX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARL5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-39-5037-01AAPTXchr9

32987758

-ARL5Bchr10

18961551

+
ChimerDB4LUSCTCGA-39-5037APTXchr9

32987758

-ARL5Bchr10

18961551

+


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Fusion Gene ORF analysis for APTX-ARL5B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397172ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000309615ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000379813ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000379817ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000379819ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000379825ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000436040ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000463596ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000468275ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000473270ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+
intron-3CDSENST00000476858ENST00000377275APTXchr9

32987758

-ARL5Bchr10

18961551

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397172APTXchr932987758-ENST00000377275ARL5Bchr1018961551+70203123596197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397172ENST00000377275APTXchr932987758-ARL5Bchr1018961551+0.001606330.9983936

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Fusion Genomic Features for APTX-ARL5B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
APTXchr932987757-ARL5Bchr1018961550+1.82E-060.9999982
APTXchr932987757-ARL5Bchr1018961550+1.82E-060.9999982
APTXchr932987757-ARL5Bchr1018961550+1.82E-060.9999982
APTXchr932987757-ARL5Bchr1018961550+1.82E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for APTX-ARL5B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32987758/chr10:18961551)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APTX

Q7Z2E3

ARL5B

Q96KC2

FUNCTION: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:16547001, ECO:0000269|PubMed:16964241, ECO:0000269|PubMed:17276982, ECO:0000269|PubMed:24362567}.FUNCTION: Binds and exchanges GTP and GDP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPTXchr9:32987758chr10:18961551ENST00000397172-4838_87103285.0DomainNote=FHA-like
TgeneARL5Bchr9:32987758chr10:18961551ENST0000037727526125_12885180.0Nucleotide bindingNote=GTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPTXchr9:32987758chr10:18961551ENST00000309615-18182_2870307.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000309615-1838_870307.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000379813-18182_2870343.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000379813-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000379817-17182_2870343.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000379817-1738_870343.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000379819-18182_2870357.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000379819-1838_870357.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000379825-18182_2870307.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000379825-1838_870307.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000397172-48182_287103285.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000436040-16182_2870445.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000436040-1638_870445.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000463596-18182_2870343.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000463596-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000468275-18182_2870343.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000468275-1838_870343.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000476858-17182_2870303.0DomainHIT
HgeneAPTXchr9:32987758chr10:18961551ENST00000476858-1738_870303.0DomainNote=FHA-like
HgeneAPTXchr9:32987758chr10:18961551ENST00000309615-18126_1310307.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000309615-18272_2760307.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000379813-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000379813-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000379817-17126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000379817-17272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000379819-18126_1310357.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000379819-18272_2760357.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000379825-18126_1310307.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000379825-18272_2760307.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000397172-48126_131103285.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000397172-48272_276103285.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000436040-16126_1310445.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000436040-16272_2760445.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000463596-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000463596-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000468275-18126_1310343.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000468275-18272_2760343.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000476858-17126_1310303.0MotifNuclear localization signal
HgeneAPTXchr9:32987758chr10:18961551ENST00000476858-17272_2760303.0MotifHistidine triad motif
HgeneAPTXchr9:32987758chr10:18961551ENST00000309615-18331_3530307.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000379813-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000379817-17331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000379819-18331_3530357.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000379825-18331_3530307.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000397172-48331_353103285.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000436040-16331_3530445.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000463596-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000468275-18331_3530343.0Zinc fingerC2H2-type
HgeneAPTXchr9:32987758chr10:18961551ENST00000476858-17331_3530303.0Zinc fingerC2H2-type
TgeneARL5Bchr9:32987758chr10:18961551ENST000003772752623_3085180.0Nucleotide bindingNote=GTP
TgeneARL5Bchr9:32987758chr10:18961551ENST000003772752666_7085180.0Nucleotide bindingGTP


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Fusion Gene Sequence for APTX-ARL5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5719_5719_1_APTX-ARL5B_APTX_chr9_32987758_ENST00000397172_ARL5B_chr10_18961551_ENST00000377275_length(transcript)=7020nt_BP=312nt
CAGATGAGTAACGTGAATTTGTCCGTCTCCGACTTCTGGAGAGTGATGATGCGGGTGTGCTGGTTGGTGAGACAGGACAGCCGGCACCAG
CGAATCAGACTTCCACATTTGGAAGCAGTTGTGATTGGGCGTGGCCCAGAGACCAAGATCACTGATAAGAAATGTTCTCGACAGCAAGTA
CAGTTGAAAGCAGAGTGTAACAAGGGATATGTCAAGGTAAAGCAGGTAGGAGTCAATCCCACCAGCATTGACTCAGTCGTAATTGGGAAG
GACCAAGAGGTGAAGCTGCAGCCTGGCCAGGTTCTCCACATGTTCATCATTCTTGTTGTTGATAGCATTGACAGGGAACGACTAGCTATT
ACAAAAGAAGAATTATACAGAATGTTGGCTCATGAGGATTTACGGAAGGCTGCAGTCCTTATCTTTGCAAATAAACAGGATATGAAAGGG
TGTATGACAGCAGCTGAAATCTCGAAATACCTCACCCTTAGTTCAATTAAGGATCATCCATGGCACATTCAATCCTGCTGTGCTCTCACA
GGAGAAGGGTTATGCCAAGGTCTAGAGTGGATGACCTCCCGGATTGGTGTGAGATAACTTTTTTGCTTGAAAGAGACTGCTCTATTTATT
CTGTGACATGAACATTTTTTCCTAGTACCTTTGGCTGCTAAGGCAGCAGCATGTTTAATTTATAACAACACAAACCTCTGAGAGCAACAC
TTGAATCAAGTGCAGCTGAACTGGAACATAAAAGATTTTTTCTTAACTTTTTTTTTTTAACACACTAATCTTCAGTTGGATGAATGTAAT
GTATAACTATGTTTTCAGCAACAATTCTTCTGTTTATTCTAATTAATCAGTGACTGCCTTGTAAGAAATGTTTGTCATATGCGTGATGTC
TTCTGAAATATTCTTATAACCTTAATGACCAATTGCTTTCAATTCTTGACCAGCACTCCCTCCCAACCAGAGAATTACTGGTTTGATAGA
GTAGTCTTGGAAACCATCAGGTACTGCCTGCAGACTTCTCCAGCACTAAATATATTTGTTCCCTCTATAAACCATTCATCTTTCGGACAG
AACTTACTGTAAAGAAAGAAATCTGCCTAGAGGATATATGTAAGGAAGATTCCACATCATGAGTACTTGCCTTTTAACTTTCCCCCACAT
TACTGTTGAGTCATGGAATAATGTTTAAGTTGTTATTTGCATGGAAATTAAGTAGGCTGTTTATTTATCTAAAGGAATCAAGTCCACTCT
TCTGCCTGCAACATTTGTTCAAAAACTAACCAAGGTAAAATATTTATTTGAAAGCCCAACTTTGATGTTAAATATTCTTGAATAAATCTG
TTATTTTAAGAATATCACATTATTCAATGCATATAAAACTATCAGAAGTTAGTAAATCATACCAGCACTAAAAATAAGACAATTGGAATA
TATTTTAGCATCAGTTTACAAACAACTTTATTATCAACAGAAATTTTAGCTCTTTTCTTTGCAAGATATATCACAGCTGCTTTGGGCAGT
AGCTGAAGCCGAAGTATGAACAGTCCATTTTGTTTCTTAAAATTTGAAGTCGTGTCTGTCATAGCATTTTTACTACCAGCAGTATGTTAC
TTAAAAAACTACATGGCTTTCCTTGAATTTATTTGACGGTATTATGTAATAGACTTGAAACAATTGCCATCTTTGTAGTTATGCCTTGGG
TTCTAAAATGTTATAGGAAACTGCTGAATTGAATCCTAGCTTTTAGAATATTAATAGGAGACTCAAAGTTAATATTCTTAACAACTTAAA
ATTAAAAAAAGTCATAATCTATCAAAAGTTTATTTATTGGATGGCATTAAAACATTTTTGAGGCAGTTGTCTAATATGAACAATAATCTA
AACAATATATTCCTTAAATTAAGAGGAAAGACAAGTGTCGTATTTCGATCCTGTTTATTCAAATGTGTGATTTTGCTGAAATGAAAGGGA
TAAAATGAATACTTAGAGAATAATACTTCATTTTTGCAGTACTTTTTAATTTTGATAAAAAAGATACAAAGTTCATAATATCAAAATATG
TGTTCAAAATTGGTATTTTAATTTTAATATTTTTGTAAGTTGATTTAAATTTTGCTCTTTTTTCAGGTGTGCTTGGTTTATTATATTTAG
TCAAGTTAATTTAGTCGAATGTGGTAACATTTTTCTGATTTATCTTTAGTTGGAGCACACCCTTGAACTGAACAGTGGCCAAAGGAAAGC
TTTCTGGGCTTTGGAAAGTAGTTGTTTAACTTTGTTTTAAGCCGTTTTCTTAGTGATTCTGTATCAAGTAGAGGATAAGTGTAGTTTAAC
TTAGTTTTTAATATAACCCATAATCAAGAACATGAGCGAAAAGCAGACATAAATCGATATGGATGGTTTGTGGTGTGTGTGGGATGTGGG
GGAATTAAGAAAATGCCATTTACCTAAGCACAGTTTGCCTGAATTTCTGCTTGGTTGTGTTGTTTACCGTAAGTACTGAGGGTAGTTTCC
CTAAGTCTGTCCTGAGAAAAAGCATACTTAGTACTCCTGTATTTGTTCTTATGAAATGACTATCTGCCTTCTTGTATCTAGTAAGATTGG
CTGGCTCAATTTTCTTCTGTCAAATTATATGGTTATTTTTTATATTACCACATCAGCATTATATTAAAAGTGTTTTTAATAGTTGATTGT
ATTTTGCCAACTACTAGTATAGACTCAAATTTGCTATTTAATTTTTAAAATACAATTTATTTTGTAAATCCTTTAAAAAATATTTGGTTA
GTTTTGGATTAGAAATGATTTATGTTAGCCATGTGTTGAAGATGAAATTGGCATCAGTGTAGACGGTGCTGATTGGGAAAAGTTCATGAT
TAGGAAATTCATGTAAGACTTTTTAAGAGTATTTTTTAGGTTTTCACTCAATCTTTCCTGTCACAGTAACGTGAAAACTGATTATTCTTT
ACTCCAAGAGAATGTTTTAACCCAAGCAAGTATCTAATACTAGAGCATTGGTTCTGACATTCATTGTAAATCAGTGAACTGTAAGATACT
GTCTAAAAAATGTACATTTGTAATTAGTGCCTTTATTCATATTTTGAAATAAGTTCTTAGTTTTATATTATACCTGTTCTTTAGAAGTCA
TGTTAGCAGCTAATTATTTCAGTGATGAAATAATTTGTGTTTTATATCCCCCTTCACCTCCATGTATTGGTTAGCACAGTTTATAGTAAG
TGAAAAGCAAGGGACCCACCTACATTACCTTCAGGAGACTGTTCTACCTTTTAATTTGAAAACAAGGAAATTAAATTTTAACAGAAATCT
TTTAAGTATGTTATAACCAAAGTGTTCAATTATCCTTGCAAGTTCAAATACAGCATTTTTCTTAATTTTGAGCGTGTCATGTCCTTCATC
TTTAAACCCATCATTCTTATTGAAGCCCATTTGAGAACTCTTAGAATTAATAGAACCTTTTATAAGGGAATATATGGAATATTTTTTATT
GTTAATGTAACTTAATTCCTTAAAACCTGGAATATTAATATATATAATCTATTAAAAGCTGAAGATTAAATATGTAATTTTTGCTTTTAG
TTTCTTGTGTTAGTATGCTTAAAGGTATCAATACTTTTATTCTATATTCATTAGAAGAAAGGTAATAAATTTAAGTTTCATTGCTGAAAA
ATTTTAAATGAGTGCCACCCCATAGCCATAGTCATTTTGATTAAGCATAATTTAACTTTCATTATAGCATAAAGAGAAAATAATTATTTT
AGTATGGAAACAGTGATAGGCAGTGCTGTAAACAATATTCTCTGAAAAGTTGTGGGGGTCACAAAGAAAATTTTAAAGAATATAGAAGCT
TTTTTAAAAAATCTTTTTAGTGTAGTTTCTTAGAACAAATTATAAACATAATCATTCTGAATAATCAATTTTTATTTAGTCCTTAACTAT
GTAAAACCGTATCAGTAGAAAAATGTGCTGGTGTCGTGTCTAAAGATGGATAAATTTCTTTGGAATTTATCTTTGGAGACCAACTTTATG
AGGCAGACTTTTTGTCTACAGCTTTGGAACCAAAAAAACTTCACTCTAATTCAGTCCTAAAGGCTATTTTACATTTTGCCGGGGTAAAGT
GACTTCAAGATACAGCATGGTGTCTTGTATCTAGTAGAATATTGTGCTAGCCATCTAAAAAAGTGGATTTGAGCCTTAATTTGGCCGTTT
CTCAATTGTCTAGTTGACCTTAGACAATTAGTGTCCATGGCTTTCCTTTTGTTTTTCCCATACTGAGGAACTTAAACTACAGCTCTAAAA
TGTCTTTTGGTTTTAAAATTCTGAATGCTTATATACTACTATTAAAAATTAAAAATCCCTCAAATAGTAGGGCAATACAGGTAATATGAA
ATTAAATGTATTTTTATCCATTATTTGATTCCCACCTGTTATTTTATTTAGAATACGAATACAACCAAGTAGGGAAAAACGTATCAGTAA
CTGCTATTCAACTTAAATTCAGCGAATTAATAGCTGAATAGAAATAGCTAATGACAATGCAAAAGAGAAAACAAGCCATATTGCTAAGAA
AAGGATAGTAAGCTGCTTAGAAAGAACCAGCCTGTGTTGGAAATAATTCTCTTCTAGATAATTTACCTTATTTTCTTGGCTTGTACTAAT
TGAATGGAAGTGGTTAATTTGTTCAGAGTTTATTGCCGTTTGATGCCACCCCAGTCTATAGTTCTGTGTGACTTTCCATATTGAAAGAGT
AGGGTTAGTAGCCAGGTTGTCAGTCTTTTACAAATGTCTACATAAATGTCTACATAAATCTGAAAGTGGTTTATATTCAAGGTTAGTTTT
TCAGTAGCGTCTCCTCCTTATTCATTCACTTTTACTGTGAAGACTGAAATCCAAAAGCCAGGTTCCCCAAAAAAGTATTTTTAAAAAATT
TTAGGGGACCAAAATAAATAGAGGAAGACCAATATAAAAAAATATGTTCAACTATTCCATTTTAAATTTAAAGCAGAAAAAAAAATTGTG
CCCCTCAGACCTAAAGGCAGCTTTAAATGTATATAGTTTGGTGAAACATTTGGGAAATATTAATTTGGAGGTTTAGAAGCATACGAAAAA
CAAATTCAAAGCACTTGAAAGTAAAGACAATATCATGAGGTCGAAAAAACTTCAAAAGGATATTAGGTAAGAGAAAATGTGAATGAAAGC
AGTGAATTTCTGCCTCTCCTCGTATTTAGGGTACTTAAAATTACTAAAAAATACTGTCTTTTTACCATACAGCTAGATGGCCTGTATTAT
TCTTAATGTGGCCAAAGGAGTGAAGACTGATTAGGGTTTTAGAATTTGGAACTGTAGTCACATAAAGGCATCTTTTGCATTTCTTAAACC
AGTAATCTACATTTTCTCCTGGAAATGGAGAAATATGAAATGTGCTGTGCATAGCTTTTGGAATAGAAAACAAAGTTTTAAAAGAATGGA
TATGTTTTCTTGCACAACTTGTAAAATTTTAATTAAAAAATTACCTCATTTTTCAATCCATAAGGTGCTTTGCTCAAGTTTGTGGGATGT
TTGTACCATCCCATAAAAACCCCCTTCACCCAAACTGTATTTGAAATATGCAAAATTCATAACTAAGGGATAGCATTCCTTGGAGACTTT
GTTTTGTTTTACTCTTGTTTACCAGCTGGGCCAACATGGTAGATATATGAGATTCACATATGGTTTCATTAAAGCACATAGGAAAGTGCT
CAGTCAATATTTAATTAGTTTAATTAGATAAGGGAAAGGAGAAATCCTAAATTTGATGGATTCTTTTATACTGTGAATATATTTCCATCA
GTGTTGGTAAGATATCAAATGACTATCAGTTGATCCCAGTCATCAGTGACTTATTTGCATATTTAAGCCCTATTCACAAGAGACCATAAT
CATTTTAATCTTATATTTTCCCTCAGGAAATTTAGGGACTCTGAAGCCCCTATTTTATTCTCTTGGAGTAAACTGTTGAGTGTAGTTACA
AAAACTTTTATTTATGACTTAAAAAAAGTTTAGCTGCTATTTCAGTGAAAGTGTAAAATAAAACGGTCATGATTTTTTTCAATTACAGAA
TAGTTACAAATTTTACCATGTTCATCTATTCCACAGAGCATGTTAAAAACAACAACAACAAAAACCTAACAGCAATTACAACCTTGGTGT
TGCGTTTATTCTAATCAGAGTGAATGATTATAATCACACTTTGCTATTTTAACATAAATTGGTGCTTTAGAGCATTAAAGAGGAAGCAGC
AGGCCCTGTACTCAGTATTTATTATTTCTTGCCTCAGAATGCAAAACAACTTTAAAGTGTCTATATTCATATATATGTGCATTTCTTAAG
ATTTAAATACAAACTGTTGTTACTCCTTAAGCTTCAGGCTTTCTGCGAAAGCTCTAAGAATATCTTCATTACTATGCTTGGTCAACTGGA
AGATGGTATTAATAAGGTCAGAATTAGGAATTGGATTGCTCTGTGGGTCCTCCGGTATTGTGCAGAGGAAAGAAAAATGTCTTTCACACC
ACAAACTGTGTGTCTGAACCCCAGCCAAACAAATGTGTTCCATTGGTCCAATATATAAGCATTAACAACAACAACAAAAAATTTAAAACA
AGTAAATTAATGCATTCACATGATCACTTCTTGAAAATGGTTCAAAGCATGTTTTCCTGATGGTGGGATTGTTTAAATGACATGTTTTAA
AGTTTTTAATACTTTATTAGTTATGAAGTGCTTCTTTTATATGTTAAGTTTAGGTTGCCAGTACTCATAATTTTTATTTCTGCAATTATG
TTATAATGAGTTGTTTGCATGCCTACTTAACCCAAGTAAAACGATGCTGTTTGCTCTGGAATGTTCATCTTTTAGACAGGTTTTGGCTCA
TTTCCAATCATGGTGCAATATAGTGTAACATTCATTTGTTTTCATTCAACAGTTTTATTTTTGTCATAATAAATAATTACTTTTCCAATA

>5719_5719_1_APTX-ARL5B_APTX_chr9_32987758_ENST00000397172_ARL5B_chr10_18961551_ENST00000377275_length(amino acids)=197AA_BP=103
MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHLEAVVIGRGPETKITDKKCSRQQVQLKAECNKGYVKVKQVGVNPTSIDSVVIGKD
QEVKLQPGQVLHMFIILVVDSIDRERLAITKEELYRMLAHEDLRKAAVLIFANKQDMKGCMTAAEISKYLTLSSIKDHPWHIQSCCALTG

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Fusion Gene PPI Analysis for APTX-ARL5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPTXchr9:32987758chr10:18961551ENST00000309615-18207_2110307.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000309615-18269_2700307.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379813-18207_2110343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379813-18269_2700343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379817-17207_2110343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379817-17269_2700343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379819-18207_2110.0357.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379819-18269_2700.0357.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379825-18207_2110307.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000379825-18269_2700307.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000397172-48207_211103.0285.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000397172-48269_270103.0285.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000436040-16207_2110445.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000436040-16269_2700445.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000463596-18207_2110343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000463596-18269_2700343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000468275-18207_2110343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000468275-18269_2700343.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000476858-17207_2110303.0DNA substrate
HgeneAPTXchr9:32987758chr10:18961551ENST00000476858-17269_2700303.0DNA substrate


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APTX-ARL5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APTX-ARL5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource