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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAPEPLD-ADD3 (FusionGDB2 ID:57228)

Fusion Gene Summary for NAPEPLD-ADD3

check button Fusion gene summary
Fusion gene informationFusion gene name: NAPEPLD-ADD3
Fusion gene ID: 57228
HgeneTgene
Gene symbol

NAPEPLD

ADD3

Gene ID

222236

120

Gene nameN-acyl phosphatidylethanolamine phospholipase Dadducin 3
SynonymsC7orf18|FMP30|NAPE-PLDADDL|CPSQ3
Cytomap

7q22.1

10q25.1-q25.2

Type of geneprotein-codingprotein-coding
DescriptionN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DNAPE-hydrolyzing phospholipase Dgamma-adducinadducin 3 (gamma)adducin-like protein 70
Modification date2020031320200313
UniProtAcc

Q6IQ20

Q9UEY8

Ensembl transtripts involved in fusion geneENST00000341533, ENST00000417955, 
ENST00000427257, ENST00000455523, 
ENST00000465647, 		ENST00000497125, 
ENST00000277900, ENST00000356080, 
ENST00000360162, 
Fusion gene scores* DoF score6 X 5 X 3=9013 X 11 X 6=858
# samples 613
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/858*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAPEPLD [Title/Abstract] AND ADD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAPEPLD(102768929)-ADD3(111883774), # samples:1
Anticipated loss of major functional domain due to fusion event.NAPEPLD-ADD3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NAPEPLD-ADD3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NAPEPLD-ADD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAPEPLD

GO:0070292

N-acylphosphatidylethanolamine metabolic process

25684574


check buttonFusion gene breakpoints across NAPEPLD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer235NNAPEPLDchr7

102768929

-ADD3chr10

111883774

+


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Fusion Gene ORF analysis for NAPEPLD-ADD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000341533ENST00000497125NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
5CDS-intronENST00000417955ENST00000497125NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
5CDS-intronENST00000427257ENST00000497125NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
5CDS-intronENST00000455523ENST00000497125NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
5CDS-intronENST00000465647ENST00000497125NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000417955ENST00000277900NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000417955ENST00000356080NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000417955ENST00000360162NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000427257ENST00000277900NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000427257ENST00000356080NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000427257ENST00000360162NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000465647ENST00000277900NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000465647ENST00000356080NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
Frame-shiftENST00000465647ENST00000360162NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
In-frameENST00000341533ENST00000277900NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
In-frameENST00000341533ENST00000356080NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
In-frameENST00000341533ENST00000360162NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
In-frameENST00000455523ENST00000277900NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
In-frameENST00000455523ENST00000356080NAPEPLDchr7

102768929

-ADD3chr10

111883774

+
In-frameENST00000455523ENST00000360162NAPEPLDchr7

102768929

-ADD3chr10

111883774

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341533NAPEPLDchr7102768929-ENST00000360162ADD3chr10111883774+23267324381613391
ENST00000341533NAPEPLDchr7102768929-ENST00000356080ADD3chr10111883774+23037324381709423
ENST00000341533NAPEPLDchr7102768929-ENST00000277900ADD3chr10111883774+35617324381613391
ENST00000455523NAPEPLDchr7102768929-ENST00000360162ADD3chr10111883774+2186592791473464
ENST00000455523NAPEPLDchr7102768929-ENST00000356080ADD3chr10111883774+2163592791569496
ENST00000455523NAPEPLDchr7102768929-ENST00000277900ADD3chr10111883774+3421592791473464

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341533ENST00000360162NAPEPLDchr7102768929-ADD3chr10111883774+0.0004720440.99952793
ENST00000341533ENST00000356080NAPEPLDchr7102768929-ADD3chr10111883774+0.0007462190.9992538
ENST00000341533ENST00000277900NAPEPLDchr7102768929-ADD3chr10111883774+0.000180620.99981946
ENST00000455523ENST00000360162NAPEPLDchr7102768929-ADD3chr10111883774+0.0005292340.9994708
ENST00000455523ENST00000356080NAPEPLDchr7102768929-ADD3chr10111883774+0.000741130.9992588
ENST00000455523ENST00000277900NAPEPLDchr7102768929-ADD3chr10111883774+0.000155440.99984455

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Fusion Genomic Features for NAPEPLD-ADD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NAPEPLDchr7102768929-ADD3chr10111883774+0.0923509750.907649
NAPEPLDchr7102768929-ADD3chr10111883774+0.0923509750.907649

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NAPEPLD-ADD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:102768929/chr10:111883774)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAPEPLD

Q6IQ20

ADD3

Q9UEY8

FUNCTION: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). {ECO:0000250|UniProtKB:Q8BH82, ECO:0000269|PubMed:14634025, ECO:0000269|PubMed:16527816, ECO:0000269|PubMed:25684574, ECO:0000269|PubMed:27571266}.FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin. {ECO:0000269|PubMed:23836506}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NAPEPLD-ADD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57228_57228_1_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000341533_ADD3_chr10_111883774_ENST00000277900_length(transcript)=3561nt_BP=732nt
CCCGCGGCCCGGGATCCCGAGTGTCCGGAGCTCCGTGGTTTCTGTTGGACCTCGCGGGAGGCGGTTTTCTCCCGCCTGCTGTGCTCTGTG
ACCTCTCTGCTGCCTCCTCCACGGTCTCTGGGCGGAGCAATCCACACTGCTGAGCCTGGGGTGGTTTGGAATTCTTCGGCGAAGTGGAGC
GGGCTGAGAGTGGGTTTCCCGTCCCCGAGCCCTCCCTCATCTCGGAGATGCCGCACTTGTGAGCGACAGGGCTTCATTTGAATTTTCGCA
CCTCGCGAGTTGCGGAGCCTGCATCTCTGAAGCTGCCTCGGTGAAGAGCCACAGCATTATTTTTTTTCTCTTTGGGAGAGTAGCTGTCTG
GGATTTGAGATCCTATCTTCCCTGCAAATTACCAGGTTGCATCTTCACTGATAGGAATACATTTCTTCACCAAAGGACATGGATGAAAAT
GAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGT
GATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGA
TTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCA
AGTTCTAAAGAGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCATTCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCA
GCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCCTCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACA
AGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGAGTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACG
TGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAAAATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAAC
CCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATATGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCT
GGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGATCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTC
ACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACAAGGCCTAGAAGAAAACCATGAGCTGTTTTCCAAGAGCTTC
ATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGATATGCATGATGTTGAAGATGAGCTTGCTAAGCGAGTGAGTAGGTTA
AGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTCTCCAGAGAAAATCGAAGAAGTCCTGTCACCTGAAGGCTCCCCTTCA
AAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTCTGAAAAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAAATAAAG
TCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACCACATTTAAGTTGATCATTAATATGCAATGGTAGATCAGAT
TGGGGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAAAGAAAAACTTTCAGATTCATCTCTCATTTTATATGTCCAG
AAATGGCTTTGAATTTTAAGCAATTACTAGTTTTAATTAGCTCTGCCCTCATGAAGTATTATTATAATTCACCATAAACAGCTATCTGTC
TGAATTACTTCAGGCCTTCTCCATAATATCTGTTAGAAAGAAATTGCCAGTGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCTTCAC
TTGATAATCATATTATAATTTTTTATCATGATTATTGACTATATTTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAA
AACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCACATAATTTTTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATT
CACAGTATAAAATTTCCTCACCTGAAGTAACTTTGTTTGCCAAAAAAGTTGTTTTAATAAACTATAATTTTTGAAAACTTCCTTTTTTAT
TAGTTTAGAAAGCCCCTTATTTTTCAACAAAGGGGATTTTGTACACATAACATGGGTTATTTAGTTTAACTCTGGCAAAAAAAAAAAAAA
AAATTTTGTATGTTGATGTTTGTATACCGTTCAGTATAAAAGTGTCCTAAGCATATTAGCCAATCTTTTCACAGTAGAGCATACTTAAGG
CTGCTTGGTACTGAGTATACTTAAATATAACTCCAGAATCCAGGGACTTGGTGTTAAAACAGGATTAGAGCATGTAAAGGTACATCTAGA
TTCATATTTGAATCTTAAACTGTATTTTTCTCTTAGTATTGCTAATGAGTAAAGAAAAGTCTCATAAGGTAGCCAAATGAAAAAGAATGA
AAGGGAAAGTGAAAAATTAAGGGGACAAAAGATGGGATGTGAAAAGAAGAATTCTAGTTTGATGGTGACTCATATTCACGATAGGATACA
AAGTGTGATTTGTTGGAAACATGTCCCAAATTTCTAAAATTCTGCTTCTCTGCCAAAAGCAATGTCTTTCTTGGTTGATATTTGAGTTTT
AAAAGGGTCAAATCTTTCTAATTTTTTGTATCTTTAGAGGGCAGCACTAGAAGAAATCAGCAGGTCTAATCCCACCAGTAAGAAAACTAC
CACTTCTTGATTTTTACAGATTTAAAAAAATCTTTTCAGTGACCTTTCTTTTTAATGTAAATACAAATTTAAACCTAGGCTTAATATAGG
CGTTTCCCCTTTCACCCAAGTGATGTCACAGTTCGATGCAAAATCAATGATCCAGAATGATCGTGGGTAAAAATAACTCAAAGTGTTTCT
TAAGGGTGAGTTGGCATGCAAAAAATTACATTGATTACAGTGTGTTTTGGAGCTGGCTCTGTTTGTGTGCATATGATAATGCAGAGTTGA
GCCAGAGCCTGGAAATGTCATTCTAGATCTCACTAACTACTGGAATCAGTGTTTTAATCTCTTGGTGGAAACTTTCAGTTGCTTAACTCT
CTATTGGAAGATTTTTTTAATGTTCTACATCATTTATGTTGTATTACAATGTATGTAGAAATAGTAACCTGTGAACTATGCTTTTCCATA
ACTTTTTAAAAATATATATATCTAAATGAATGCAATGTGCATAAATATTTTTTAAACATAACAGTGAACTATTGCACCTTTTGCTAATGC
CTCTATTTACTTGCTTTGGCATAAAGAATGAGCCAATGAACCTCTGTGTCCTGTGGAAAAATGTATAAATGTTATCTGATATTGCTCTTA

>57228_57228_1_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000341533_ADD3_chr10_111883774_ENST00000277900_length(amino acids)=391AA_BP=91
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPR
TKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNP
FSHLTEGELEEYKRTIERKQQGLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPE

--------------------------------------------------------------
>57228_57228_2_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000341533_ADD3_chr10_111883774_ENST00000356080_length(transcript)=2303nt_BP=732nt
CCCGCGGCCCGGGATCCCGAGTGTCCGGAGCTCCGTGGTTTCTGTTGGACCTCGCGGGAGGCGGTTTTCTCCCGCCTGCTGTGCTCTGTG
ACCTCTCTGCTGCCTCCTCCACGGTCTCTGGGCGGAGCAATCCACACTGCTGAGCCTGGGGTGGTTTGGAATTCTTCGGCGAAGTGGAGC
GGGCTGAGAGTGGGTTTCCCGTCCCCGAGCCCTCCCTCATCTCGGAGATGCCGCACTTGTGAGCGACAGGGCTTCATTTGAATTTTCGCA
CCTCGCGAGTTGCGGAGCCTGCATCTCTGAAGCTGCCTCGGTGAAGAGCCACAGCATTATTTTTTTTCTCTTTGGGAGAGTAGCTGTCTG
GGATTTGAGATCCTATCTTCCCTGCAAATTACCAGGTTGCATCTTCACTGATAGGAATACATTTCTTCACCAAAGGACATGGATGAAAAT
GAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGT
GATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGA
TTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCA
AGTTCTAAAGAGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCATTCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCA
GCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCCTCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACA
AGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGAGTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACG
TGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAAAATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAAC
CCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATATGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCT
GGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGATCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTC
ACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACAAGGCCTAGAAGATGCTGAGCAGGAATTACTCTCAGATGAC
GCTTCATCTGTTTCACAAATTCAGTCTCAAACTCAGTCACCGCAAAATGTCCCTGAAAAATTAGAAGAAAACCATGAGCTGTTTTCCAAG
AGCTTCATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGATATGCATGATGTTGAAGATGAGCTTGCTAAGCGAGTGAGT
AGGTTAAGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTCTCCAGAGAAAATCGAAGAAGTCCTGTCACCTGAAGGCTCC
CCTTCAAAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTCTGAAAAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAA
ATAAAGTCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACCACATTTAAGTTGATCATTAATATGCAATGGTAGA
TCAGATTGGGGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAAAGAAAAACTTTCAGATTCATCTCTCATTTTATAT
GTCCAGAAATGGCTTTGAATTTTAAGCAATTACTAGTTTTAATTAGCTCTGCCCTCATGAAGTATTATTATAATTCACCATAAACAGCTA
TCTGTCTGAATTACTTCAGGCCTTCTCCATAATATCTGTTAGAAAGAAATTGCCAGTGAGCAAGTGAGAATTTTTATTTCTCAATACCTG
CTTCACTTGATAATCATATTATAATTTTTTATCATGATTATTGACTATATTTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGC
TTTAAAAACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCACATAATTTTTTAAAAAGTTTTAAGAAAAGATTCATTTGGAAT

>57228_57228_2_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000341533_ADD3_chr10_111883774_ENST00000356080_length(amino acids)=423AA_BP=91
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPR
TKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNP
FSHLTEGELEEYKRTIERKQQGLEDAEQELLSDDASSVSQIQSQTQSPQNVPEKLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELA

--------------------------------------------------------------
>57228_57228_3_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000341533_ADD3_chr10_111883774_ENST00000360162_length(transcript)=2326nt_BP=732nt
CCCGCGGCCCGGGATCCCGAGTGTCCGGAGCTCCGTGGTTTCTGTTGGACCTCGCGGGAGGCGGTTTTCTCCCGCCTGCTGTGCTCTGTG
ACCTCTCTGCTGCCTCCTCCACGGTCTCTGGGCGGAGCAATCCACACTGCTGAGCCTGGGGTGGTTTGGAATTCTTCGGCGAAGTGGAGC
GGGCTGAGAGTGGGTTTCCCGTCCCCGAGCCCTCCCTCATCTCGGAGATGCCGCACTTGTGAGCGACAGGGCTTCATTTGAATTTTCGCA
CCTCGCGAGTTGCGGAGCCTGCATCTCTGAAGCTGCCTCGGTGAAGAGCCACAGCATTATTTTTTTTCTCTTTGGGAGAGTAGCTGTCTG
GGATTTGAGATCCTATCTTCCCTGCAAATTACCAGGTTGCATCTTCACTGATAGGAATACATTTCTTCACCAAAGGACATGGATGAAAAT
GAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGT
GATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGA
TTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCA
AGTTCTAAAGAGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCATTCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCA
GCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCCTCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACA
AGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGAGTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACG
TGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAAAATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAAC
CCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATATGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCT
GGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGATCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTC
ACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACAAGGCCTAGAAGAAAACCATGAGCTGTTTTCCAAGAGCTTC
ATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGATATGCATGATGTTGAAGATGAGCTTGCTAAGCGAGTGAGTAGGTTA
AGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTCTCCAGAGAAAATCGAAGAAGTCCTGTCACCTGAAGGCTCCCCTTCA
AAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTCTGAAAAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAAATAAAG
TCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACCACATTTAAGTTGATCATTAATATGCAATGGTAGATCAGAT
TGGGGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAAAGAAAAACTTTCAGATTCATCTCTCATTTTATATGTCCAG
AAATGGCTTTGAATTTTAAGCAATTACTAGTTTTAATTAGCTCTGCCCTCATGAAGTATTATTATAATTCACCATAAACAGCTATCTGTC
TGAATTACTTCAGGCCTTCTCCATAATATCTGTTAGAAAGAAATTGCCAGTGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCTTCAC
TTGATAATCATATTATAATTTTTTATCATGATTATTGACTATATTTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAA
AACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCACATAATTTTTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATT
CACAGTATAAAATTTCCTCACCTGAAGTAACTTTGTTTGCCAAAAAAGTTGTTTTAATAAACTATAATTTTTGAAAACTTCCTTTTTTAT

>57228_57228_3_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000341533_ADD3_chr10_111883774_ENST00000360162_length(amino acids)=391AA_BP=91
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPR
TKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNP
FSHLTEGELEEYKRTIERKQQGLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPE

--------------------------------------------------------------
>57228_57228_4_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000455523_ADD3_chr10_111883774_ENST00000277900_length(transcript)=3421nt_BP=592nt
GAAGGAGGCCACCGCTGGCCCTGCTGTCAGATTCGAAGGTCATAATAAGGGAGTGACCCGGCGACGACTCGCCCCAACGATGGCGAGGCG
GCGAGAGCTGAAGCGCTGCCTGCAGCTGCTGGCGTCCTCGGCGGAGCCAGCGCGGCGGGCTCGGGTTAGGAAGAACCCGAGCGCCTGCCG
CGGTCGCCCCTCCCGCTACGCGGCGGCGCTTTGCGCGGGGACTCTGTGGCCGGAAGCCGCGGAACTGAGGCGGCGCGCGCTCCCGGCCAC
CCCAAGCGCGAGTTCTTCACCAAAGGACATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGT
AAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGA
AGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCT
CAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCAT
TCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCAGCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCC
TCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACAAGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGA
GTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACGTGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAA
AATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAACCCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATA
TGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCTGGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGA
TCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTCACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACA
AGGCCTAGAAGAAAACCATGAGCTGTTTTCCAAGAGCTTCATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGATATGCA
TGATGTTGAAGATGAGCTTGCTAAGCGAGTGAGTAGGTTAAGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTCTCCAGA
GAAAATCGAAGAAGTCCTGTCACCTGAAGGCTCCCCTTCAAAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTCTGAA
AAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAAATAAAGTCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACC
ACATTTAAGTTGATCATTAATATGCAATGGTAGATCAGATTGGGGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAA
AGAAAAACTTTCAGATTCATCTCTCATTTTATATGTCCAGAAATGGCTTTGAATTTTAAGCAATTACTAGTTTTAATTAGCTCTGCCCTC
ATGAAGTATTATTATAATTCACCATAAACAGCTATCTGTCTGAATTACTTCAGGCCTTCTCCATAATATCTGTTAGAAAGAAATTGCCAG
TGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCTTCACTTGATAATCATATTATAATTTTTTATCATGATTATTGACTATATTTTTGG
AGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAAAACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCACATAATTT
TTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATTCACAGTATAAAATTTCCTCACCTGAAGTAACTTTGTTTGCCAAAAAAGTT
GTTTTAATAAACTATAATTTTTGAAAACTTCCTTTTTTATTAGTTTAGAAAGCCCCTTATTTTTCAACAAAGGGGATTTTGTACACATAA
CATGGGTTATTTAGTTTAACTCTGGCAAAAAAAAAAAAAAAAATTTTGTATGTTGATGTTTGTATACCGTTCAGTATAAAAGTGTCCTAA
GCATATTAGCCAATCTTTTCACAGTAGAGCATACTTAAGGCTGCTTGGTACTGAGTATACTTAAATATAACTCCAGAATCCAGGGACTTG
GTGTTAAAACAGGATTAGAGCATGTAAAGGTACATCTAGATTCATATTTGAATCTTAAACTGTATTTTTCTCTTAGTATTGCTAATGAGT
AAAGAAAAGTCTCATAAGGTAGCCAAATGAAAAAGAATGAAAGGGAAAGTGAAAAATTAAGGGGACAAAAGATGGGATGTGAAAAGAAGA
ATTCTAGTTTGATGGTGACTCATATTCACGATAGGATACAAAGTGTGATTTGTTGGAAACATGTCCCAAATTTCTAAAATTCTGCTTCTC
TGCCAAAAGCAATGTCTTTCTTGGTTGATATTTGAGTTTTAAAAGGGTCAAATCTTTCTAATTTTTTGTATCTTTAGAGGGCAGCACTAG
AAGAAATCAGCAGGTCTAATCCCACCAGTAAGAAAACTACCACTTCTTGATTTTTACAGATTTAAAAAAATCTTTTCAGTGACCTTTCTT
TTTAATGTAAATACAAATTTAAACCTAGGCTTAATATAGGCGTTTCCCCTTTCACCCAAGTGATGTCACAGTTCGATGCAAAATCAATGA
TCCAGAATGATCGTGGGTAAAAATAACTCAAAGTGTTTCTTAAGGGTGAGTTGGCATGCAAAAAATTACATTGATTACAGTGTGTTTTGG
AGCTGGCTCTGTTTGTGTGCATATGATAATGCAGAGTTGAGCCAGAGCCTGGAAATGTCATTCTAGATCTCACTAACTACTGGAATCAGT
GTTTTAATCTCTTGGTGGAAACTTTCAGTTGCTTAACTCTCTATTGGAAGATTTTTTTAATGTTCTACATCATTTATGTTGTATTACAAT
GTATGTAGAAATAGTAACCTGTGAACTATGCTTTTCCATAACTTTTTAAAAATATATATATCTAAATGAATGCAATGTGCATAAATATTT
TTTAAACATAACAGTGAACTATTGCACCTTTTGCTAATGCCTCTATTTACTTGCTTTGGCATAAAGAATGAGCCAATGAACCTCTGTGTC
CTGTGGAAAAATGTATAAATGTTATCTGATATTGCTCTTAGATGTAATGCTAATTAATGTTAAATCACAAATAAACAGTATTTTAAATAT

>57228_57228_4_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000455523_ADD3_chr10_111883774_ENST00000277900_length(amino acids)=464AA_BP=164
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEGYRTGYAYR
HPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDSSKVSGG
TPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGELEEYKRTIE
RKQQGLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPEGSPSKSPSKKKKKFRTP

--------------------------------------------------------------
>57228_57228_5_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000455523_ADD3_chr10_111883774_ENST00000356080_length(transcript)=2163nt_BP=592nt
GAAGGAGGCCACCGCTGGCCCTGCTGTCAGATTCGAAGGTCATAATAAGGGAGTGACCCGGCGACGACTCGCCCCAACGATGGCGAGGCG
GCGAGAGCTGAAGCGCTGCCTGCAGCTGCTGGCGTCCTCGGCGGAGCCAGCGCGGCGGGCTCGGGTTAGGAAGAACCCGAGCGCCTGCCG
CGGTCGCCCCTCCCGCTACGCGGCGGCGCTTTGCGCGGGGACTCTGTGGCCGGAAGCCGCGGAACTGAGGCGGCGCGCGCTCCCGGCCAC
CCCAAGCGCGAGTTCTTCACCAAAGGACATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGT
AAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGA
AGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCT
CAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCAT
TCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCAGCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCC
TCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACAAGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGA
GTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACGTGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAA
AATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAACCCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATA
TGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCTGGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGA
TCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTCACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACA
AGGCCTAGAAGATGCTGAGCAGGAATTACTCTCAGATGACGCTTCATCTGTTTCACAAATTCAGTCTCAAACTCAGTCACCGCAAAATGT
CCCTGAAAAATTAGAAGAAAACCATGAGCTGTTTTCCAAGAGCTTCATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGA
TATGCATGATGTTGAAGATGAGCTTGCTAAGCGAGTGAGTAGGTTAAGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTC
TCCAGAGAAAATCGAAGAAGTCCTGTCACCTGAAGGCTCCCCTTCAAAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTT
TCTGAAAAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAAATAAAGTCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTA
AATACCACATTTAAGTTGATCATTAATATGCAATGGTAGATCAGATTGGGGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTT
TACAAAAGAAAAACTTTCAGATTCATCTCTCATTTTATATGTCCAGAAATGGCTTTGAATTTTAAGCAATTACTAGTTTTAATTAGCTCT
GCCCTCATGAAGTATTATTATAATTCACCATAAACAGCTATCTGTCTGAATTACTTCAGGCCTTCTCCATAATATCTGTTAGAAAGAAAT
TGCCAGTGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCTTCACTTGATAATCATATTATAATTTTTTATCATGATTATTGACTATAT
TTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAAAACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCACA
TAATTTTTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATTCACAGTATAAAATTTCCTCACCTGAAGTAACTTTGTTTGCCAAA

>57228_57228_5_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000455523_ADD3_chr10_111883774_ENST00000356080_length(amino acids)=496AA_BP=164
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEGYRTGYAYR
HPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDSSKVSGG
TPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGELEEYKRTIE
RKQQGLEDAEQELLSDDASSVSQIQSQTQSPQNVPEKLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEI

--------------------------------------------------------------
>57228_57228_6_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000455523_ADD3_chr10_111883774_ENST00000360162_length(transcript)=2186nt_BP=592nt
GAAGGAGGCCACCGCTGGCCCTGCTGTCAGATTCGAAGGTCATAATAAGGGAGTGACCCGGCGACGACTCGCCCCAACGATGGCGAGGCG
GCGAGAGCTGAAGCGCTGCCTGCAGCTGCTGGCGTCCTCGGCGGAGCCAGCGCGGCGGGCTCGGGTTAGGAAGAACCCGAGCGCCTGCCG
CGGTCGCCCCTCCCGCTACGCGGCGGCGCTTTGCGCGGGGACTCTGTGGCCGGAAGCCGCGGAACTGAGGCGGCGCGCGCTCCCGGCCAC
CCCAAGCGCGAGTTCTTCACCAAAGGACATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGT
AAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGA
AGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCT
CAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGGGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCAT
TCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCAGCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCC
TCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACAAGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGA
GTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACGTGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAA
AATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAACCCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATA
TGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCTGGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGA
TCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTCACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACA
AGGCCTAGAAGAAAACCATGAGCTGTTTTCCAAGAGCTTCATCTCCATGGAAGTGCCTGTCATGGTAGTAAATGGCAAGGATGATATGCA
TGATGTTGAAGATGAGCTTGCTAAGCGAGTGAGTAGGTTAAGCACAAGTACAACCATAGAAAACATCGAGATTACTATTAAGTCTCCAGA
GAAAATCGAAGAAGTCCTGTCACCTGAAGGCTCCCCTTCAAAATCGCCATCCAAGAAAAAGAAGAAATTCCGCACTCCTTCTTTTCTGAA
AAAGAACAAAAAAAAGGAGAAAGTTGAGGCCTAAATAAAGTCTTTTTATAATTATTATTATAACAATGTGACATTGCACATCTAAATACC
ACATTTAAGTTGATCATTAATATGCAATGGTAGATCAGATTGGGGGATGTAGCAAACTGGACTTTAAGAACTGGAAAGAGGTTTTACAAA
AGAAAAACTTTCAGATTCATCTCTCATTTTATATGTCCAGAAATGGCTTTGAATTTTAAGCAATTACTAGTTTTAATTAGCTCTGCCCTC
ATGAAGTATTATTATAATTCACCATAAACAGCTATCTGTCTGAATTACTTCAGGCCTTCTCCATAATATCTGTTAGAAAGAAATTGCCAG
TGAGCAAGTGAGAATTTTTATTTCTCAATACCTGCTTCACTTGATAATCATATTATAATTTTTTATCATGATTATTGACTATATTTTTGG
AGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAAAACTTCTAAGACAAGAATCTATAGCATTAGTATACACTGGCACATAATTT
TTTAAAAAGTTTTAAGAAAAGATTCATTTGGAATTTTATTCACAGTATAAAATTTCCTCACCTGAAGTAACTTTGTTTGCCAAAAAAGTT
GTTTTAATAAACTATAATTTTTGAAAACTTCCTTTTTTATTAGTTTAGAAAGCCCCTTATTTTTCAACAAAGGGGATTTTGTACACATAA

>57228_57228_6_NAPEPLD-ADD3_NAPEPLD_chr7_102768929_ENST00000455523_ADD3_chr10_111883774_ENST00000360162_length(amino acids)=464AA_BP=164
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEGYRTGYAYR
HPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDSSKVSGG
TPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGELEEYKRTIE
RKQQGLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPEGSPSKSPSKKKKKFRTP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NAPEPLD-ADD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneADD3chr7:102768929chr10:111883774ENST00000277900814684_701381.0675.0calmodulin
TgeneADD3chr7:102768929chr10:111883774ENST00000356080815684_701381.0707.0calmodulin
TgeneADD3chr7:102768929chr10:111883774ENST00000360162814684_701381.0675.0calmodulin


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAPEPLD-ADD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAPEPLD-ADD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource