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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NAPEPLD-RELN (FusionGDB2 ID:57231)

Fusion Gene Summary for NAPEPLD-RELN

Fusion gene summary

Fusion gene information	Fusion gene name: NAPEPLD-RELN
	Fusion gene ID: 57231
		Hgene	Tgene
	Gene symbol	NAPEPLD	RELN
	Gene ID	222236	5649
	Gene name	N-acyl phosphatidylethanolamine phospholipase D	reelin
	Synonyms	C7orf18\|FMP30\|NAPE-PLD	ETL7\|LIS2\|PRO1598\|RL
	Cytomap	7q22.1	7q22.1
	Type of gene	protein-coding	protein-coding
	Description	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DNAPE-hydrolyzing phospholipase D	reelin
	Modification date	20200313	20200322
	UniProtAcc	Q6IQ20	.
	Ensembl transtripts involved in fusion gene	ENST00000341533, ENST00000417955, ENST00000427257, ENST00000455523, ENST00000465647,	ENST00000473945, ENST00000343529, ENST00000424685, ENST00000428762,
Fusion gene scores	* DoF score	6 X 5 X 3=90	11 X 11 X 6=726
	# samples	6	11
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/726*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NAPEPLD [Title/Abstract] AND RELN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NAPEPLD(102768930)-RELN(103143677), # samples:3
Anticipated loss of major functional domain due to fusion event.	NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. NAPEPLD-RELN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NAPEPLD	GO:0070292	N-acylphosphatidylethanolamine metabolic process	25684574

Fusion gene breakpoints across NAPEPLD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RELN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AJ-A2QM-01A	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-

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Fusion Gene ORF analysis for NAPEPLD-RELN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000341533	ENST00000473945	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
5CDS-intron	ENST00000417955	ENST00000473945	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
5CDS-intron	ENST00000427257	ENST00000473945	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
5CDS-intron	ENST00000455523	ENST00000473945	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
5CDS-intron	ENST00000465647	ENST00000473945	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000417955	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000417955	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000417955	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000427257	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000427257	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000427257	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000465647	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000465647	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
Frame-shift	ENST00000465647	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
In-frame	ENST00000341533	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
In-frame	ENST00000341533	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
In-frame	ENST00000341533	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
In-frame	ENST00000455523	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
In-frame	ENST00000455523	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-
In-frame	ENST00000455523	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341533	NAPEPLD	chr7	102768930	-	ENST00000343529	RELN	chr7	103143677	-	3863	732	438	2834	798
ENST00000341533	NAPEPLD	chr7	102768930	-	ENST00000428762	RELN	chr7	103143677	-	3869	732	438	2840	800
ENST00000341533	NAPEPLD	chr7	102768930	-	ENST00000424685	RELN	chr7	103143677	-	3869	732	438	2840	800
ENST00000455523	NAPEPLD	chr7	102768930	-	ENST00000343529	RELN	chr7	103143677	-	3723	592	79	2694	871
ENST00000455523	NAPEPLD	chr7	102768930	-	ENST00000428762	RELN	chr7	103143677	-	3729	592	79	2700	873
ENST00000455523	NAPEPLD	chr7	102768930	-	ENST00000424685	RELN	chr7	103143677	-	3729	592	79	2700	873

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341533	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000528951	0.999471
ENST00000341533	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000515142	0.9994848
ENST00000341533	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000528266	0.9994717
ENST00000455523	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000187951	0.99981207
ENST00000455523	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000187056	0.999813
ENST00000455523	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000187601	0.9998124

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Fusion Genomic Features for NAPEPLD-RELN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAPEPLD-RELN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:102768930/chr7:103143677)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NAPEPLD Q6IQ20	.
FUNCTION: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). {ECO:0000250\|UniProtKB:Q8BH82, ECO:0000269\|PubMed:14634025, ECO:0000269\|PubMed:16527816, ECO:0000269\|PubMed:25684574, ECO:0000269\|PubMed:27571266}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3431_3460

2758

3459.0

Compositional bias

Note=Arg-rich (basic)

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3431_3460

2758

3461.0

Compositional bias

Note=Arg-rich (basic)

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2852_2883

2758

3459.0

Domain

EGF-like 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3227_3259

2758

3459.0

Domain

EGF-like 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2852_2883

2758

3461.0

Domain

EGF-like 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3227_3259

2758

3461.0

Domain

EGF-like 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2777_2788

2758

3459.0

Repeat

Note=BNR 13

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2978_2989

2758

3459.0

Repeat

Note=BNR 14

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3142_3154

2758

3459.0

Repeat

Note=BNR 15

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3362_3373

2758

3459.0

Repeat

Note=BNR 16

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2777_2788

2758

3461.0

Repeat

Note=BNR 13

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2978_2989

2758

3461.0

Repeat

Note=BNR 14

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3142_3154

2758

3461.0

Repeat

Note=BNR 15

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3362_3373

2758

3461.0

Repeat

Note=BNR 16

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1029_1060

2758

3459.0

Domain

EGF-like 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1408_1441

2758

3459.0

Domain

EGF-like 3

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1764_1795

2758

3459.0

Domain

EGF-like 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2128_2160

2758

3459.0

Domain

EGF-like 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2477_2508

2758

3459.0

Domain

EGF-like 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

26_190

2758

3459.0

Domain

Reelin

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

670_701

2758

3459.0

Domain

EGF-like 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1029_1060

2758

3461.0

Domain

EGF-like 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1408_1441

2758

3461.0

Domain

EGF-like 3

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1764_1795

2758

3461.0

Domain

EGF-like 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2128_2160

2758

3461.0

Domain

EGF-like 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2477_2508

2758

3461.0

Domain

EGF-like 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

26_190

2758

3461.0

Domain

Reelin

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

670_701

2758

3461.0

Domain

EGF-like 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1156_1167

2758

3459.0

Repeat

Note=BNR 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1322_1333

2758

3459.0

Repeat

Note=BNR 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1534_1545

2758

3459.0

Repeat

Note=BNR 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1685_1696

2758

3459.0

Repeat

Note=BNR 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1883_1894

2758

3459.0

Repeat

Note=BNR 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2042_2053

2758

3459.0

Repeat

Note=BNR 9

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2249_2260

2758

3459.0

Repeat

Note=BNR 10

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2398_2409

2758

3459.0

Repeat

Note=BNR 11

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2597_2608

2758

3459.0

Repeat

Note=BNR 12

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

592_603

2758

3459.0

Repeat

Note=BNR 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

798_809

2758

3459.0

Repeat

Note=BNR 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

951_962

2758

3459.0

Repeat

Note=BNR 3

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1156_1167

2758

3461.0

Repeat

Note=BNR 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1322_1333

2758

3461.0

Repeat

Note=BNR 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1534_1545

2758

3461.0

Repeat

Note=BNR 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1685_1696

2758

3461.0

Repeat

Note=BNR 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1883_1894

2758

3461.0

Repeat

Note=BNR 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2042_2053

2758

3461.0

Repeat

Note=BNR 9

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2249_2260

2758

3461.0

Repeat

Note=BNR 10

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2398_2409

2758

3461.0

Repeat

Note=BNR 11

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2597_2608

2758

3461.0

Repeat

Note=BNR 12

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

592_603

2758

3461.0

Repeat

Note=BNR 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

798_809

2758

3461.0

Repeat

Note=BNR 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

951_962

2758

3461.0

Repeat

Note=BNR 3

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Fusion Gene Sequence for NAPEPLD-RELN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>57231_57231_1_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000343529_length(transcript)=3863nt_BP=732nt
CCCGCGGCCCGGGATCCCGAGTGTCCGGAGCTCCGTGGTTTCTGTTGGACCTCGCGGGAGGCGGTTTTCTCCCGCCTGCTGTGCTCTGTG
ACCTCTCTGCTGCCTCCTCCACGGTCTCTGGGCGGAGCAATCCACACTGCTGAGCCTGGGGTGGTTTGGAATTCTTCGGCGAAGTGGAGC
GGGCTGAGAGTGGGTTTCCCGTCCCCGAGCCCTCCCTCATCTCGGAGATGCCGCACTTGTGAGCGACAGGGCTTCATTTGAATTTTCGCA
CCTCGCGAGTTGCGGAGCCTGCATCTCTGAAGCTGCCTCGGTGAAGAGCCACAGCATTATTTTTTTTCTCTTTGGGAGAGTAGCTGTCTG
GGATTTGAGATCCTATCTTCCCTGCAAATTACCAGGTTGCATCTTCACTGATAGGAATACATTTCTTCACCAAAGGACATGGATGAAAAT
GAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGT
GATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGA
TTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCA
AGTTCTAAAGAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCAGAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTG
AGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTCTGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAA
GGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCCGGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAG
TGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAGGGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGAT
CCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTTCCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGAC
TTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCTTGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTG
AGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCAATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCT
TGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTACCGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGAT
TACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGATGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCT
TTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTGGGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAAT
CCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGAAAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGA
TTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGACAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATA
CAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCACTTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACT
AAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCCTTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTC
CATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAATCACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACA
CAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGCAATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTC
TGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGAGAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGAC
CTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGCAAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGC
TGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGGCTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTC
ACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCAGACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCT
GTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTGGCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAA
GCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGTCTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGT
CATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTCACTCGCAAACAAAATTACATGATGAATTTTTCACGACAACATGGGCTCAGA
CATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATGAAGAATCAAAAAGTTTATTTTTTTTCTTCCAACATGTGATGTGTTG
CTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAATATCTGTGAAGGACTTGGTGATTACCTGAAAGCCCTTCTCAAGACC
GAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGACTTATTTGCTCATAAGTAAATGTCTTCATGTTGATGTGTCCGTGAAA
GTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAATAAGAAACAGTTTAACAGAAAAATGAAATTTAAGCACAAAAAATTT
AAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACATTCTTGGTCACAAAGCTATTTAAGTGGACTGTATTTCGGCTATGTC
TCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTATTCTCTTCTACAATACAACACATTGAAACTGTATTTACTTGTTATG
TTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCAGAAAATTAATTGAAATACCTATTCAAGAAGATAGTTGTAAAGATAT
TGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAGCGTTGTTTTGTGGATAAGAAAAATGCTTGACCCTGAAATATTTTCT
ACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTCCCATTTCCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTGGCTGAT
TTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGATTTGTAAAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCGTGGATT
GTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTACAACACCAGCAACATTATAATGGCCCTGTAGCTCTGAATGCTATTTG

>57231_57231_1_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000343529_length(amino acids)=798AA_BP=98
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKY
SDMQWAIDNFYLGPGCLDNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFG
GSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLR
WWQPFVISNGIVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSR
ELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVS
SSATQFRWIQKGEETEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGV
IGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPK

--------------------------------------------------------------
>57231_57231_2_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000424685_length(transcript)=3869nt_BP=732nt
CCCGCGGCCCGGGATCCCGAGTGTCCGGAGCTCCGTGGTTTCTGTTGGACCTCGCGGGAGGCGGTTTTCTCCCGCCTGCTGTGCTCTGTG
ACCTCTCTGCTGCCTCCTCCACGGTCTCTGGGCGGAGCAATCCACACTGCTGAGCCTGGGGTGGTTTGGAATTCTTCGGCGAAGTGGAGC
GGGCTGAGAGTGGGTTTCCCGTCCCCGAGCCCTCCCTCATCTCGGAGATGCCGCACTTGTGAGCGACAGGGCTTCATTTGAATTTTCGCA
CCTCGCGAGTTGCGGAGCCTGCATCTCTGAAGCTGCCTCGGTGAAGAGCCACAGCATTATTTTTTTTCTCTTTGGGAGAGTAGCTGTCTG
GGATTTGAGATCCTATCTTCCCTGCAAATTACCAGGTTGCATCTTCACTGATAGGAATACATTTCTTCACCAAAGGACATGGATGAAAAT
GAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGT
GATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGA
TTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCA
AGTTCTAAAGAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCAGAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTG
AGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTCTGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAA
GGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCCGGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAG
TGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAGGGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGAT
CCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTTCCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGAC
TTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCTTGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTG
AGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCAATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCT
TGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTACCGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGAT
TACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGATGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCT
TTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTGGGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAAT
CCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGAAAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGA
TTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGACAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATA
CAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCACTTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACT
AAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCCTTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTC
CATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAATCACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACA
CAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGCAATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTC
TGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGAGAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGAC
CTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGCAAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGC
TGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGGCTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTC
ACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCAGACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCT
GTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTGGCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAA
GCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGTCTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGT
CATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTATTTAGCACTCGCAAACAAAATTACATGATGAATTTTTCACGACAACATGGG
CTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATGAAGAATCAAAAAGTTTATTTTTTTTCTTCCAACATGTGAT
GTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAATATCTGTGAAGGACTTGGTGATTACCTGAAAGCCCTTCTC
AAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGACTTATTTGCTCATAAGTAAATGTCTTCATGTTGATGTGTCC
GTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAATAAGAAACAGTTTAACAGAAAAATGAAATTTAAGCACAAA
AAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACATTCTTGGTCACAAAGCTATTTAAGTGGACTGTATTTCGGC
TATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTATTCTCTTCTACAATACAACACATTGAAACTGTATTTACTT
GTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCAGAAAATTAATTGAAATACCTATTCAAGAAGATAGTTGTAA
AGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAGCGTTGTTTTGTGGATAAGAAAAATGCTTGACCCTGAAATA
TTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTCCCATTTCCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTG
GCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGATTTGTAAAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCG
TGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTACAACACCAGCAACATTATAATGGCCCTGTAGCTCTGAATGC

>57231_57231_2_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000424685_length(amino acids)=800AA_BP=98
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKY
SDMQWAIDNFYLGPGCLDNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFG
GSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLR
WWQPFVISNGIVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSR
ELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVS
SSATQFRWIQKGEETEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGV
IGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPK

--------------------------------------------------------------
>57231_57231_3_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000428762_length(transcript)=3869nt_BP=732nt
CCCGCGGCCCGGGATCCCGAGTGTCCGGAGCTCCGTGGTTTCTGTTGGACCTCGCGGGAGGCGGTTTTCTCCCGCCTGCTGTGCTCTGTG
ACCTCTCTGCTGCCTCCTCCACGGTCTCTGGGCGGAGCAATCCACACTGCTGAGCCTGGGGTGGTTTGGAATTCTTCGGCGAAGTGGAGC
GGGCTGAGAGTGGGTTTCCCGTCCCCGAGCCCTCCCTCATCTCGGAGATGCCGCACTTGTGAGCGACAGGGCTTCATTTGAATTTTCGCA
CCTCGCGAGTTGCGGAGCCTGCATCTCTGAAGCTGCCTCGGTGAAGAGCCACAGCATTATTTTTTTTCTCTTTGGGAGAGTAGCTGTCTG
GGATTTGAGATCCTATCTTCCCTGCAAATTACCAGGTTGCATCTTCACTGATAGGAATACATTTCTTCACCAAAGGACATGGATGAAAAT
GAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGT
GATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGA
TTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCA
AGTTCTAAAGAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCAGAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTG
AGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTCTGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAA
GGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCCGGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAG
TGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAGGGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGAT
CCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTTCCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGAC
TTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCTTGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTG
AGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCAATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCT
TGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTACCGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGAT
TACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGATGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCT
TTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTGGGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAAT
CCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGAAAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGA
TTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGACAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATA
CAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCACTTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACT
AAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCCTTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTC
CATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAATCACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACA
CAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGCAATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTC
TGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGAGAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGAC
CTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGCAAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGC
TGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGGCTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTC
ACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCAGACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCT
GTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTGGCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAA
GCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGTCTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGT
CATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTAGTAAGCACTCGCAAACAAAATTACATGATGAATTTTTCACGACAACATGGG
CTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATGAAGAATCAAAAAGTTTATTTTTTTTCTTCCAACATGTGAT
GTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAATATCTGTGAAGGACTTGGTGATTACCTGAAAGCCCTTCTC
AAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGACTTATTTGCTCATAAGTAAATGTCTTCATGTTGATGTGTCC
GTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAATAAGAAACAGTTTAACAGAAAAATGAAATTTAAGCACAAA
AAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACATTCTTGGTCACAAAGCTATTTAAGTGGACTGTATTTCGGC
TATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTATTCTCTTCTACAATACAACACATTGAAACTGTATTTACTT
GTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCAGAAAATTAATTGAAATACCTATTCAAGAAGATAGTTGTAA
AGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAGCGTTGTTTTGTGGATAAGAAAAATGCTTGACCCTGAAATA
TTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTCCCATTTCCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTG
GCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGATTTGTAAAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCG
TGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTACAACACCAGCAACATTATAATGGCCCTGTAGCTCTGAATGC

>57231_57231_3_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000428762_length(amino acids)=800AA_BP=98
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKY
SDMQWAIDNFYLGPGCLDNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFG
GSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLR
WWQPFVISNGIVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSR
ELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVS
SSATQFRWIQKGEETEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGV
IGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPK

--------------------------------------------------------------
>57231_57231_4_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000343529_length(transcript)=3723nt_BP=592nt
GAAGGAGGCCACCGCTGGCCCTGCTGTCAGATTCGAAGGTCATAATAAGGGAGTGACCCGGCGACGACTCGCCCCAACGATGGCGAGGCG
GCGAGAGCTGAAGCGCTGCCTGCAGCTGCTGGCGTCCTCGGCGGAGCCAGCGCGGCGGGCTCGGGTTAGGAAGAACCCGAGCGCCTGCCG
CGGTCGCCCCTCCCGCTACGCGGCGGCGCTTTGCGCGGGGACTCTGTGGCCGGAAGCCGCGGAACTGAGGCGGCGCGCGCTCCCGGCCAC
CCCAAGCGCGAGTTCTTCACCAAAGGACATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGT
AAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGA
AGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCT
CAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCA
GAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTGAGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTC
TGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAAGGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCC
GGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAGTGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAG
GGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGATCCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTT
CCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGACTTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCT
TGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTGAGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCA
ATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCTTGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTAC
CGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGATTACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGA
TGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCTTTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTG
GGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAATCCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGA
AAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGATTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGA
CAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATACAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCAC
TTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACTAAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCC
TTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTCCATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAAT
CACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACACAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGC
AATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTCTGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGA
GAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGACCTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGC
AAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGCTGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGG
CTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTCACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCA
GACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCTGTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTG
GCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAAGCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGT
CTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGTCATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTCACTCGCAAACA
AAATTACATGATGAATTTTTCACGACAACATGGGCTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATGAAGAAT
CAAAAAGTTTATTTTTTTTCTTCCAACATGTGATGTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAATATCTG
TGAAGGACTTGGTGATTACCTGAAAGCCCTTCTCAAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGACTTATTT
GCTCATAAGTAAATGTCTTCATGTTGATGTGTCCGTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAATAAGAA
ACAGTTTAACAGAAAAATGAAATTTAAGCACAAAAAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACATTCTTG
GTCACAAAGCTATTTAAGTGGACTGTATTTCGGCTATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTATTCTCT
TCTACAATACAACACATTGAAACTGTATTTACTTGTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCAGAAAAT
TAATTGAAATACCTATTCAAGAAGATAGTTGTAAAGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAGCGTTGT
TTTGTGGATAAGAAAAATGCTTGACCCTGAAATATTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTCCCATTT
CCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTGGCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGATTTGTA
AAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCGTGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTACAACACC
AGCAACATTATAATGGCCCTGTAGCTCTGAATGCTATTTGTGTAACTGAAAGGTTGCACTCTAGGGTGAACCAAGCTATAAAAGCCCATG

>57231_57231_4_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000343529_length(amino acids)=871AA_BP=171
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------
>57231_57231_5_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000424685_length(transcript)=3729nt_BP=592nt
GAAGGAGGCCACCGCTGGCCCTGCTGTCAGATTCGAAGGTCATAATAAGGGAGTGACCCGGCGACGACTCGCCCCAACGATGGCGAGGCG
GCGAGAGCTGAAGCGCTGCCTGCAGCTGCTGGCGTCCTCGGCGGAGCCAGCGCGGCGGGCTCGGGTTAGGAAGAACCCGAGCGCCTGCCG
CGGTCGCCCCTCCCGCTACGCGGCGGCGCTTTGCGCGGGGACTCTGTGGCCGGAAGCCGCGGAACTGAGGCGGCGCGCGCTCCCGGCCAC
CCCAAGCGCGAGTTCTTCACCAAAGGACATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGT
AAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGA
AGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCT
CAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCA
GAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTGAGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTC
TGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAAGGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCC
GGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAGTGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAG
GGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGATCCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTT
CCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGACTTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCT
TGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTGAGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCA
ATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCTTGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTAC
CGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGATTACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGA
TGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCTTTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTG
GGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAATCCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGA
AAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGATTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGA
CAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATACAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCAC
TTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACTAAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCC
TTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTCCATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAAT
CACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACACAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGC
AATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTCTGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGA
GAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGACCTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGC
AAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGCTGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGG
CTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTCACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCA
GACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCTGTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTG
GCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAAGCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGT
CTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGTCATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTATTTAGCACTCG
CAAACAAAATTACATGATGAATTTTTCACGACAACATGGGCTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATG
AAGAATCAAAAAGTTTATTTTTTTTCTTCCAACATGTGATGTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAA
TATCTGTGAAGGACTTGGTGATTACCTGAAAGCCCTTCTCAAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGAC
TTATTTGCTCATAAGTAAATGTCTTCATGTTGATGTGTCCGTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAA
TAAGAAACAGTTTAACAGAAAAATGAAATTTAAGCACAAAAAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACA
TTCTTGGTCACAAAGCTATTTAAGTGGACTGTATTTCGGCTATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTA
TTCTCTTCTACAATACAACACATTGAAACTGTATTTACTTGTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCA
GAAAATTAATTGAAATACCTATTCAAGAAGATAGTTGTAAAGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAG
CGTTGTTTTGTGGATAAGAAAAATGCTTGACCCTGAAATATTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTC
CCATTTCCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTGGCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGA
TTTGTAAAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCGTGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTAC
AACACCAGCAACATTATAATGGCCCTGTAGCTCTGAATGCTATTTGTGTAACTGAAAGGTTGCACTCTAGGGTGAACCAAGCTATAAAAG

>57231_57231_5_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000424685_length(amino acids)=873AA_BP=171
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------
>57231_57231_6_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000428762_length(transcript)=3729nt_BP=592nt
GAAGGAGGCCACCGCTGGCCCTGCTGTCAGATTCGAAGGTCATAATAAGGGAGTGACCCGGCGACGACTCGCCCCAACGATGGCGAGGCG
GCGAGAGCTGAAGCGCTGCCTGCAGCTGCTGGCGTCCTCGGCGGAGCCAGCGCGGCGGGCTCGGGTTAGGAAGAACCCGAGCGCCTGCCG
CGGTCGCCCCTCCCGCTACGCGGCGGCGCTTTGCGCGGGGACTCTGTGGCCGGAAGCCGCGGAACTGAGGCGGCGCGCGCTCCCGGCCAC
CCCAAGCGCGAGTTCTTCACCAAAGGACATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCAGT
AAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCTAGGAAAAGCTTCAAACTGGATTATAGACTAGA
AGAAGATGTAACTAAATCCAAGAAAGGAAAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTTCT
CAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGATCTCAGTTGGATGTAAGGTGTCTGAAAAAATTGCCCA
GAATCAAATTCATGTGCAGTATTCTACTGACTTCGGTGTGAGTTGGAATTATCTGGTCCCTCAGTGCTTGCCTGCTGACCCAAAATGCTC
TGGAAGTGTTTCTCAGCCATCTGTATTCTTTCCAACTAAAGGGTGGAAAAGGATCACCTACCCACTTCCTGAAAGCTTAGTGGGAAATCC
GGTAAGGTTTAGGTTCTATCAGAAGTACTCAGACATGCAGTGGGCAATCGATAATTTCTACCTGGGCCCTGGATGCTTGGACAACTGCAG
GGGCCATGGAGATTGCTTAAGGGAACAGTGCATCTGTGATCCGGGATACTCAGGGCCAAACTGCTACTTGACCCACACTCTGAAGACTTT
CCTGAAGGAACGCTTTGACAGTGAAGAAATCAAACCTGACTTATGGATGTCCTTAGAAGGTGGAAGTACTTGCACTGAGTGTGGAATTCT
TGCCGAGGACACTGCACTCTATTTTGGGGGATCCACTGTGAGACAAGCGGTTACACAAGATTTGGATCTTCGAGGTGCAAAGTTCCTGCA
ATACTGGGGGCGCATCGGTAGTGAGAACAACATGACCTCTTGCCATCGTCCCATCTGCCGGAAGGAAGGCGTGCTGTTGGACTACTCTAC
CGATGGAGGAATTACCTGGACTTTGCTCCATGAGATGGATTACCAGAAATACATTTCTGTTAGACACGACTACATACTTCTTCCTGAAGA
TGCCCTCACCAACACAACTCGACTTCGCTGGTGGCAGCCTTTTGTGATCAGCAATGGAATTGTGGTCTCTGGGGTGGAGCGTGCTCAGTG
GGCACTGGACAACATTTTGATTGGTGGAGCAGAAATCAATCCCAGCCAATTGGTGGACACTTTTGATGATGAAGGCACTTCCCATGAAGA
AAACTGGAGTTTTTACCCTAATGCTGTAAGGACAGCAGGATTTTGTGGCAATCCATCCTTTCACCTCTATTGGCCAAATAAAAAGAAGGA
CAAGACTCACAATGCTCTCTCCTCCCGAGAACTCATTATACAGCCAGGATACATGATGCAGTTTAAAATTGTGGTGGGTTGTGAAGCCAC
TTCTTGTGGTGACCTTCATTCCGTAATGCTGGAATACACTAAGGATGCAAGATCGGATTCCTGGCAGCTCGTACAGACCCAGTGCCTTCC
TTCCTCTTCTAACAGCATTGGCTGCTCCCCTTTCCAGTTCCATGAAGCCACCATCTACAACTCTGTCAACAGCTCAAGCTGGAAAAGAAT
CACCATCCAGCTGCCTGACCATGTCTCCTCTAGTGCAACACAGTTCCGCTGGATCCAGAAGGGAGAAGAAACTGAGAAGCAAAGCTGGGC
AATTGACCACGTGTACATTGGAGAGGCTTGCCCCAAGCTCTGCAGCGGGCACGGATACTGCACGACCGGTGCCATCTGCATCTGCGACGA
GAGCTTCCAAGGTGATGACTGCTCTGTTTTCAGTCACGACCTTCCCAGTTATATTAAAGATAATTTTGAGTCCGCAAGAGTCACCGAGGC
AAACTGGGAGACCATTCAAGGTGGAGTCATAGGAAGTGGCTGTGGGCAGCTGGCCCCCTACGCCCATGGAGACTCACTGTACTTTAATGG
CTGTCAGATCAGGCAAGCAGCTACCAAGCCTCTGGATCTCACTCGAGCAAGCAAAATCATGTTTGTTTTGCAAATTGGGAGCATGTCGCA
GACGGACAGCTGCAACAGTGACCTGAGTGGCCCCCACGCTGTGGACAAGGCAGTGCTGCTGCAATACAGCGTCAACAACGGGATCACCTG
GCATGTCATCGCCCAGCACCAGCCAAAGGACTTCACACAAGCTCAGAGAGTGTCTTACAATGTCCCCCTGGAGGCACGGATGAAAGGAGT
CTTACTGCGCTGGTGGCAACCACGCCACAATGGAACAGGTCATGATCAATGGGCTTTGGACCATGTGGAGGTCGTCCTAGTAAGCACTCG
CAAACAAAATTACATGATGAATTTTTCACGACAACATGGGCTCAGACATTTCTACAACAGAAGACGAAGGTCACTTAGGCGATACCCATG
AAGAATCAAAAAGTTTATTTTTTTTCTTCCAACATGTGATGTGTTGCTCTCCATTCTTTTAAATCTCGCACTACATCTGATATCAGGAAA
TATCTGTGAAGGACTTGGTGATTACCTGAAAGCCCTTCTCAAGACCGAGTGTACACCACTTTCCCACACTGTGAACTAATGACAAGTGAC
TTATTTGCTCATAAGTAAATGTCTTCATGTTGATGTGTCCGTGAAAGTTGTGATCTGTTGTAATATCAGTTACAGTGGCAGTATTGACAA
TAAGAAACAGTTTAACAGAAAAATGAAATTTAAGCACAAAAAATTTAAGAGATTTTATGTTTAAAATGGCATTTAGCACAGTATTTAACA
TTCTTGGTCACAAAGCTATTTAAGTGGACTGTATTTCGGCTATGTCTCATGTTTTATATGATTAAATTATCATTGTTTGTCCTTTATGTA
TTCTCTTCTACAATACAACACATTGAAACTGTATTTACTTGTTATGTTGTAATATTTTGCTGCTGAATTTGGGGCTACTTATATTCTGCA
GAAAATTAATTGAAATACCTATTCAAGAAGATAGTTGTAAAGATATTGTATCTCCTTTAATATACTCCTTAAAAATGTATGTTGGTTTAG
CGTTGTTTTGTGGATAAGAAAAATGCTTGACCCTGAAATATTTTCTACTTTAAATTGTGGATGAAGACCCTATCTCCCACAAATAAGTTC
CCATTTCCTTGTCTAAAGATCTTTTTTTAAGTGTTCTGTGGCTGATTTACTAACAGTAACTGCCATTTTTTGTCTGTGATAACAGAGTGA
TTTGTAAAACAGTGGTTGTTTTTTCATTGTGTTTTCTTCGTGGATTGTTTTTTCTGCGGGTCATATTCATACCTTCTGATGAAGTTGTAC
AACACCAGCAACATTATAATGGCCCTGTAGCTCTGAATGCTATTTGTGTAACTGAAAGGTTGCACTCTAGGGTGAACCAAGCTATAAAAG

>57231_57231_6_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000428762_length(amino acids)=873AA_BP=171
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NAPEPLD-RELN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NAPEPLD-RELN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NAPEPLD-RELN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source