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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NAPG-EXOC4 (FusionGDB2 ID:57234)

Fusion Gene Summary for NAPG-EXOC4

Fusion gene summary

Fusion gene information	Fusion gene name: NAPG-EXOC4
	Fusion gene ID: 57234
		Hgene	Tgene
	Gene symbol	NAPG	EXOC4
	Gene ID	8774	60412
	Gene name	NSF attachment protein gamma	exocyst complex component 4
	Synonyms	GAMMASNAP	SEC8\|SEC8L1\|Sec8p
	Cytomap	18p11.22	7q33
	Type of gene	protein-coding	protein-coding
	Description	gamma-soluble NSF attachment proteinN-ethylmaleimide-sensitive factor attachment protein, gammaSNAP-gammasoluble NSF attachment protein	exocyst complex component 4SEC8-like 1exocyst complex component Sec8
	Modification date	20200320	20200320
	UniProtAcc	Q99747	Q96A65
	Ensembl transtripts involved in fusion gene	ENST00000322897, ENST00000542979,	ENST00000460346, ENST00000541309, ENST00000545148, ENST00000253861, ENST00000393161, ENST00000539845,
Fusion gene scores	* DoF score	7 X 3 X 6=126	35 X 25 X 10=8750
	# samples	7	39
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(39/8750*10)=-4.48773698785744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NAPG [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NAPG(10526155)-EXOC4(133002038), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NAPG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8080-01A	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+

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Fusion Gene ORF analysis for NAPG-EXOC4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000322897	ENST00000460346	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5CDS-intron	ENST00000322897	ENST00000541309	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5CDS-intron	ENST00000322897	ENST00000545148	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5UTR-3CDS	ENST00000542979	ENST00000253861	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5UTR-3CDS	ENST00000542979	ENST00000393161	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5UTR-3CDS	ENST00000542979	ENST00000539845	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5UTR-intron	ENST00000542979	ENST00000460346	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5UTR-intron	ENST00000542979	ENST00000541309	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
5UTR-intron	ENST00000542979	ENST00000545148	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
In-frame	ENST00000322897	ENST00000253861	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
In-frame	ENST00000322897	ENST00000393161	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+
In-frame	ENST00000322897	ENST00000539845	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000322897

NAPG

chr18

10526155

ENST00000253861

EXOC4

chr7

133002038

3625

125

2393

794

ENST00000322897

NAPG

chr18

10526155

ENST00000539845

EXOC4

chr7

133002038

2453

125

2393

794

ENST00000322897

NAPG

chr18

10526155

ENST00000393161

EXOC4

chr7

133002038

1044

125

890

293

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000322897	ENST00000253861	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+	0.00229683	0.99770314
ENST00000322897	ENST00000539845	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+	0.007143658	0.99285626
ENST00000322897	ENST00000393161	NAPG	chr18	10526155	+	EXOC4	chr7	133002038	+	0.002167388	0.9978326

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Fusion Genomic Features for NAPG-EXOC4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NAPG	chr18	10526155	+	EXOC4	chr7	133002037	+	7.08E-07	0.9999993
NAPG	chr18	10526155	+	EXOC4	chr7	133002037	+	7.08E-07	0.9999993

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAPG-EXOC4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:10526155/chr7:133002038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NAPG Q99747	EXOC4 Q96A65
FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EXOC4

chr18:10526155

chr7:133002038

ENST00000253861

32_114

218

975.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

EXOC4

chr18:10526155

chr7:133002038

ENST00000393161

32_114

218

474.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for NAPG-EXOC4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>57234_57234_1_NAPG-EXOC4_NAPG_chr18_10526155_ENST00000322897_EXOC4_chr7_133002038_ENST00000253861_length(transcript)=3625nt_BP=125nt
GGCGGATTCTTGGCGCCGGAGGAAGAGGCAGGGTCACCCTCTCTCCACGTCAGAGACCTGACTGTGGAGATGGCGGCTCAGAAGATAAAC
GAGGGGCTGGAACACCTCGCCAAAGCAGAGAAATACTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTGATGTTACAAACCTCCCTACT
CCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGCAGGACATCAAGGAAGATTTA
GAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGAAGATCCCAGAAACAGTTAAG
GCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACAGTGGCTATCAGCGGGGGGAG
AACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATGCTGTAGCCGCTGCACACTCT
GTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATGATATGGCAGATGTATGGGTG
AAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTGAACCATCAGCTCAACTAAGC
TATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTCTTTTCAAGTTCGAATCGTCC
TCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAACTGCAAGGGGGTCCTGATGAC
AACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAGCCAGAAACATTACCGTCATATTCCACCCATTACTAAGATTTATT
CAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTC
AATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATG
AAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTG
AGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTC
CAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAAT
ATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATT
GGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTG
GAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACG
GATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTC
TTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGT
ATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTC
CAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATC
AAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAG
TACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCAC
GCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGC
GAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCCTCA
GTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCTTAGTTTTCTCTACAGTGATACTTTAGTGGAGAGGAGGTGTAA
GGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAGGCGACAGTACAGAGTGTTTTGGTTGAACAACTACTTTAATGC
AGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCAAATTGTTGGACTCTGAAAAACAAGTGGATGGATTACTAATAT
TTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGAAAGTAGGCTGCTACCTAACTTTTAGTCCCTTCCAAAACCATT
TAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCTTATCCGTTTACAGTTCAATGAAATAAGTGTATGTGCATTGCT
GTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTTTACAACAAACTTCCCTAACCAAAACAGAACCTCTAATTTAGG
GCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTATGCTGTATCTTGTACACAGGTTGTAGGTTGGTTTATTGCCATT
TTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAACTATGGAGGAATGAAAGGCAATTCAAACATCTGCTTGATTCC
CGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTGCATCTCACTTGAAACATCCTTTGGGGGTAAATGATTCTTAGG
TGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAGTGACATTTCTCCTCTGTGCGGCCTCCAGCTGAGCCTGTCTCT
GAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCACACTGGACCTCACCATGTCCCCCGGTCACCAGTCCTCTTGCTG
CCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCACATCTTGAAAACTCGTGGAAAGGGAAAGGGGAGGAGATGGGAC
TTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTGTACCTGTTTGTACAACTTTGGTCTTGATGGGAAAAATGGAGA

>57234_57234_1_NAPG-EXOC4_NAPG_chr18_10526155_ENST00000322897_EXOC4_chr7_133002038_ENST00000253861_length(amino acids)=794AA_BP=39
MAPEEEAGSPSLHVRDLTVEMAAQKINEGLEHLAKAEKYSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD
PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
ISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQV
LAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSE
EKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWL
ASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDY
DPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYE

--------------------------------------------------------------
>57234_57234_2_NAPG-EXOC4_NAPG_chr18_10526155_ENST00000322897_EXOC4_chr7_133002038_ENST00000393161_length(transcript)=1044nt_BP=125nt
GGCGGATTCTTGGCGCCGGAGGAAGAGGCAGGGTCACCCTCTCTCCACGTCAGAGACCTGACTGTGGAGATGGCGGCTCAGAAGATAAAC
GAGGGGCTGGAACACCTCGCCAAAGCAGAGAAATACTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTGATGTTACAAACCTCCCTACT
CCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGCAGGACATCAAGGAAGATTTA
GAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGAAGATCCCAGAAACAGTTAAG
GCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACAGTGGCTATCAGCGGGGGGAG
AACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATGCTGTAGCCGCTGCACACTCT
GTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATGATATGGCAGATGTATGGGTG
AAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTGAACCATCAGCTCAACTAAGC
TATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTCTTTTCAAGTTCGAATCGTCC
TCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAACTGCAAGGGTAGCGGCGAAGA
AATCCACCAGAAAGACAATCAAAGTAACATTAAAAAGCTCAAATTTTACAAAAGTTAAGTTCCTGCCAACATTTTCAATTTATCATACAA

>57234_57234_2_NAPG-EXOC4_NAPG_chr18_10526155_ENST00000322897_EXOC4_chr7_133002038_ENST00000393161_length(amino acids)=293AA_BP=39
MAPEEEAGSPSLHVRDLTVEMAAQKINEGLEHLAKAEKYSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD
PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA

--------------------------------------------------------------
>57234_57234_3_NAPG-EXOC4_NAPG_chr18_10526155_ENST00000322897_EXOC4_chr7_133002038_ENST00000539845_length(transcript)=2453nt_BP=125nt
GGCGGATTCTTGGCGCCGGAGGAAGAGGCAGGGTCACCCTCTCTCCACGTCAGAGACCTGACTGTGGAGATGGCGGCTCAGAAGATAAAC
GAGGGGCTGGAACACCTCGCCAAAGCAGAGAAATACTCCCTCGTGAAAGATGCTTCTGTTCCTCTGATTGATGTTACAAACCTCCCTACT
CCTCGAAAATTCCTTGATACCTCTCACTATTCTACTGCTGGAAGCTCAAGTGTGAGGGAGATAAATCTGCAGGACATCAAGGAAGATTTA
GAATTGGATCCAGAGGAAAACAGCACCCTGTTTATGGGTATCCTCATTAAGGGCTTGGCGAAACTGAAGAAGATCCCAGAAACAGTTAAG
GCAATCATAGAGCGCTTGGAGCAGGAGTTGAAGCAAATTGTGAAGAGGTCTACAACCCAGGTGGCAGACAGTGGCTATCAGCGGGGGGAG
AACGTTACTGTGGAGAACCAACCAAGGTTGCTTCTAGAACTGCTGGAGTTACTGTTTGACAAGTTTAATGCTGTAGCCGCTGCACACTCT
GTGGTCCTGGGATACCTGCAGGACACTGTAGTGACTCCACTGACTCAGCAGGAAGATATCAAACTGTATGATATGGCAGATGTATGGGTG
AAGATCCAAGATGTTCTACAGATGCTATTAACTGAGTACTTGGATATGAAAAATACTCGTACGGCCTCTGAACCATCAGCTCAACTAAGC
TATGCCAGCACTGGACGAGAGTTTGCAGCCTTTTTTGCCAAGAAGAAACCTCAAAGGCCAAAAAATTCTCTTTTCAAGTTCGAATCGTCC
TCCCATGCCATCAGTATGAGCGCCTATCTGCGAGAACAGAGAAGGGAGCTCTATAGTCGGAGTGGAGAACTGCAAGGGGGTCCTGATGAC
AACTTAATTGAAGGTGGAGGAACAAAATTTGTCTGCAAACCTGGAGCCAGAAACATTACCGTCATATTCCACCCATTACTAAGATTTATT
CAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTC
AATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATG
AAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAGAGCACAATCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTG
AGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTC
CAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAAT
ATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATT
GGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTG
GAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACG
GATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTC
TTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGT
ATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTC
CAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATC
AAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAG
TACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCAC
GCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGC
GAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCCTCA

>57234_57234_3_NAPG-EXOC4_NAPG_chr18_10526155_ENST00000322897_EXOC4_chr7_133002038_ENST00000539845_length(amino acids)=794AA_BP=39
MAPEEEAGSPSLHVRDLTVEMAAQKINEGLEHLAKAEKYSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELD
PEENSTLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVL
GYLQDTVVTPLTQQEDIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
ISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKNIFLNQV
LAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSE
EKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWL
ASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDY
DPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NAPG-EXOC4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NAPG-EXOC4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NAPG-EXOC4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source