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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NARS2-RSF1 (FusionGDB2 ID:57279)

Fusion Gene Summary for NARS2-RSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: NARS2-RSF1
Fusion gene ID: 57279
HgeneTgene
Gene symbol

NARS2

RSF1

Gene ID

79731

51773

Gene nameasparaginyl-tRNA synthetase 2, mitochondrialremodeling and spacing factor 1
SynonymsDFNB94|SLM5|asnRSHBXAP|RSF-1|XAP8|p325
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionprobable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrialremodeling and spacing factor 1HBV pX-associated protein 8hepatitis B virus x-associated proteinp325 subunit of RSF chromatin-remodeling complex
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000281038, ENST00000528850, 
ENST00000530604, ENST00000480887, 
ENST00000308488, ENST00000360355, 
Fusion gene scores* DoF score19 X 16 X 7=212816 X 11 X 7=1232
# samples 2219
** MAII scorelog2(22/2128*10)=-3.27392272197653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1232*10)=-2.69693093236395
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NARS2 [Title/Abstract] AND RSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRSF1(77531574)-NARS2(78154804), # samples:3
NARS2(78239888)-RSF1(77378536), # samples:1
NARS2(78240831)-RSF1(77416391), # samples:1
Anticipated loss of major functional domain due to fusion event.NARS2-RSF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NARS2-RSF1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NARS2-RSF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRSF1

GO:0006334

nucleosome assembly

12972596

TgeneRSF1

GO:0006338

chromatin remodeling

9836642

TgeneRSF1

GO:0006352

DNA-templated transcription, initiation

9836642

TgeneRSF1

GO:0016584

nucleosome positioning

9836642

TgeneRSF1

GO:0043392

negative regulation of DNA binding

12972596

TgeneRSF1

GO:0045892

negative regulation of transcription, DNA-templated

11944984

TgeneRSF1

GO:0045893

positive regulation of transcription, DNA-templated

11788598

TgeneRSF1

GO:0050434

positive regulation of viral transcription

11788598


check buttonFusion gene breakpoints across NARS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-QQ-A5VC-01ANARS2chr11

78239888

-RSF1chr11

77378536

-
ChiTaRS5.0N/ABF947498NARS2chr11

78240831

+RSF1chr11

77416391

-


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Fusion Gene ORF analysis for NARS2-RSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000281038ENST00000530604NARS2chr11

78239888

-RSF1chr11

77378536

-
5CDS-intronENST00000528850ENST00000530604NARS2chr11

78239888

-RSF1chr11

77378536

-
Frame-shiftENST00000281038ENST00000480887NARS2chr11

78239888

-RSF1chr11

77378536

-
Frame-shiftENST00000528850ENST00000480887NARS2chr11

78239888

-RSF1chr11

77378536

-
In-frameENST00000281038ENST00000308488NARS2chr11

78239888

-RSF1chr11

77378536

-
In-frameENST00000281038ENST00000360355NARS2chr11

78239888

-RSF1chr11

77378536

-
In-frameENST00000528850ENST00000308488NARS2chr11

78239888

-RSF1chr11

77378536

-
In-frameENST00000528850ENST00000360355NARS2chr11

78239888

-RSF1chr11

77378536

-
intron-intronENST00000281038ENST00000308488NARS2chr11

78240831

+RSF1chr11

77416391

-
intron-intronENST00000281038ENST00000360355NARS2chr11

78240831

+RSF1chr11

77416391

-
intron-intronENST00000281038ENST00000480887NARS2chr11

78240831

+RSF1chr11

77416391

-
intron-intronENST00000281038ENST00000530604NARS2chr11

78240831

+RSF1chr11

77416391

-
intron-intronENST00000528850ENST00000308488NARS2chr11

78240831

+RSF1chr11

77416391

-
intron-intronENST00000528850ENST00000360355NARS2chr11

78240831

+RSF1chr11

77416391

-
intron-intronENST00000528850ENST00000480887NARS2chr11

78240831

+RSF1chr11

77416391

-
intron-intronENST00000528850ENST00000530604NARS2chr11

78240831

+RSF1chr11

77416391

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281038NARS2chr1178239888-ENST00000308488RSF1chr1177378536-856110652951089264
ENST00000281038NARS2chr1178239888-ENST00000360355RSF1chr1177378536-232710652951089264
ENST00000528850NARS2chr1178239888-ENST00000308488RSF1chr1177378536-8441945364969201
ENST00000528850NARS2chr1178239888-ENST00000360355RSF1chr1177378536-2207945364969201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281038ENST00000308488NARS2chr1178239888-RSF1chr1177378536-0.0001831430.99981683
ENST00000281038ENST00000360355NARS2chr1178239888-RSF1chr1177378536-0.0007340590.99926597
ENST00000528850ENST00000308488NARS2chr1178239888-RSF1chr1177378536-0.6384860.361514
ENST00000528850ENST00000360355NARS2chr1178239888-RSF1chr1177378536-0.93808770.061912313

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Fusion Genomic Features for NARS2-RSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NARS2-RSF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:77531574/chr11:78154804)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRSF1chr11:78239888chr11:77378536ENST0000030848814161286_129212501442.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST0000030848814161419_142412501442.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST0000036035513151286_129212191411.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST0000036035513151419_142412191411.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST000004808879111080_10839981190.0Compositional biasNote=Poly-Ala
TgeneRSF1chr11:78239888chr11:77378536ENST000004808879111146_12439981190.0Compositional biasNote=Arg-rich
TgeneRSF1chr11:78239888chr11:77378536ENST000004808879111286_12929981190.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST000004808879111419_14249981190.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRSF1chr11:78239888chr11:77378536ENST000003084881416942_101212501442.0Coiled coilOntology_term=ECO:0000255
TgeneRSF1chr11:78239888chr11:77378536ENST000003603551315942_101212191411.0Coiled coilOntology_term=ECO:0000255
TgeneRSF1chr11:78239888chr11:77378536ENST00000480887911942_10129981190.0Coiled coilOntology_term=ECO:0000255
TgeneRSF1chr11:78239888chr11:77378536ENST0000030848814161080_108312501442.0Compositional biasNote=Poly-Ala
TgeneRSF1chr11:78239888chr11:77378536ENST0000030848814161146_124312501442.0Compositional biasNote=Arg-rich
TgeneRSF1chr11:78239888chr11:77378536ENST000003084881416226_37212501442.0Compositional biasNote=Glu-rich
TgeneRSF1chr11:78239888chr11:77378536ENST000003084881416875_88412501442.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST0000036035513151080_108312191411.0Compositional biasNote=Poly-Ala
TgeneRSF1chr11:78239888chr11:77378536ENST0000036035513151146_124312191411.0Compositional biasNote=Arg-rich
TgeneRSF1chr11:78239888chr11:77378536ENST000003603551315226_37212191411.0Compositional biasNote=Glu-rich
TgeneRSF1chr11:78239888chr11:77378536ENST000003603551315875_88412191411.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST00000480887911226_3729981190.0Compositional biasNote=Glu-rich
TgeneRSF1chr11:78239888chr11:77378536ENST00000480887911875_8849981190.0Compositional biasNote=Poly-Glu
TgeneRSF1chr11:78239888chr11:77378536ENST00000308488141617_8412501442.0DomainNote=DDT
TgeneRSF1chr11:78239888chr11:77378536ENST00000360355131517_8412191411.0DomainNote=DDT
TgeneRSF1chr11:78239888chr11:77378536ENST0000048088791117_849981190.0DomainNote=DDT
TgeneRSF1chr11:78239888chr11:77378536ENST000003084881416891_94112501442.0Zinc fingerPHD-type
TgeneRSF1chr11:78239888chr11:77378536ENST000003603551315891_94112191411.0Zinc fingerPHD-type
TgeneRSF1chr11:78239888chr11:77378536ENST00000480887911891_9419981190.0Zinc fingerPHD-type


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Fusion Gene Sequence for NARS2-RSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57279_57279_1_NARS2-RSF1_NARS2_chr11_78239888_ENST00000281038_RSF1_chr11_77378536_ENST00000308488_length(transcript)=8561nt_BP=1065nt
GTAGCGTGATGACGTAAGCGGCGTTGGCGTGGTGTGGTAGGAGTGGTTGCGCGTGTTGCGGCCCGGGTTCTGTTCGTAGGTTTACAATTG
TCGCGGGTAGTGGGGCGCCCCAGCTGCCAACTGCACGTGGTTTCTTTCTGGCGTTTGCCTAGTGTCCTGTCCATTCCGCCCCGTTGGGAA
GTGGGAAGCGGAGAGGTTCTGTGGGGACAGAGCTGGGAGTCCTGAAGGAGAAAGCGCGCAGCCGAGGGGCTCTGGAGTGCCTTAGAGCAG
AGCTGCGGCCGCGGAAGGGGAGCAGCTGAGAAAGGAGGGCCGCTGCAGGCGGGGTTCGAACCGTGGGGTCTGGGCTGCTCCCGCGGAGGG
CCTGGGCGGACGCGGGATGCTGGGGGTCCGCTGCCTGCTGCGGTCCGTGCGCTTCTGTTCCTCCGCCCCCTTCCCCAAGCACAAACCTTC
AGCCAAACTGAGCGTGCGGGACGCTCTCGGGGCTCAGAACGCGAGTGGGGAGCGCATTAAGATCCAGGGATGGATTCGTTCTGTCCGATC
CCAGAAGGAAGTCTTGTTCCTGCATGTAAATGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGA
ATTAAATTTTGGGAGTTCTGTGGAAGTACAAGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAAT
TAAAGTTATTGGAAATTGTGATGCCAAGGATTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTT
TAGGTGTAGGACTAACGTTCTGGGTTCTATATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTT
TGTACATATTCATACTCCAATAATCACATCCAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGT
ACCTGAGGAGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGAGAGCTATTTGTCCA
AGAACTCTGAAGATGATGAGCTAGCTAAAGAATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATG
AGGAGGAGGAGGAAGAGGAAGGCAAACCATCCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATG
GAGATGCAAATCAGCCTGCCCGTGACAGCCAGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTG
ATGAGGAAGAGGACTTTGAAAATGTAGGCAAAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCC
CTGGCAAAGCCATTGAGAACTTGATTGGCAAGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCT
CCAATGGGACAAGTGGTGGGCAGGAGGCAGGAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCT
GTAACAGTGAACAGTTATAAGACTTTTTTTCCATTTTTGTGCTAATTTATTCCACGGTAGCTCTCACACCAGCGGGCCAGTTATTAAAAG
CTGTTTAATTTTTCCTAGAAAACTCCACTACAGAATGACTTTTAGAAGAAAAATTTCAACAAATCCTGAAGTCTTTCTGTGAAGTGACCA
GTTCTGAACTTTGAAGATAAATAATTGCTGTAAATTCCTTTTGATTTTCTTTTTCCAGGTTCATGGTCCTTGGTAATTTCATTCATGGAA
AAAAATCTTATTATAATAACAACAAAGATTTGTATATTTTTGACTTTATATTTCCTGAGCTCTCCTGACTTTGTGAAAAAGGGTGGATGA
AAATGCATTCCGAATCTGTGAGGGCCCAAAACAGAATTTAGGGGTGGGTGAAAGCACTTGTGCTTTAGCTTTTTCATATTAAATATATAT
TATATTTAAACATTCATGGCATAGATGATGATTTACAGACAATTTAAAAGTTCAAGTCTGTACTGTTACAGTTTGAGAATTGTAGATAAC
ATCATACATAAGTCATTTAGTAACAGCCTTTGTGAAATGAACTTGTTTACTATTGGAGATAACCACACTTAATAAAGAAGAGACAGTGAA
AGTACCATCATAATTAACCTAAATTTTTGTTATAGCAGAGTTTCTTGTTTAAAAAAAAATAAAATCATCTGAAAAGCATTTGTACAGTAA
AATGTATAATGAAGCTTTGCCAACCAGACTGTGCTAGCAACAAATTTTTTTAAATAAGCTTTATGCAGTGGTAATAAGGTGGCCTCAAAT
ATATTGTGTCTGATGGAGAGTTATTAGTGAAATGAATGTGGTCTTTCTTAAGGCCTGGGTGGACTGTAAACTTTGCCAATAGTATAACTC
TTGTCTTCTGGCCACTTGATGTTTAAATATCTGAAATATCATTTTGAAAAAAATACATCTATATATAACATACATGAAGAGATGCTAAGC
TGACAGTGATATTTTAGCACATTTGAAGACTGGGAAGAGATTTTCAGGTGAATTTTAACTGGTCTATTCTTGCCCTTAGTATCTACTTCA
AATTGAAGTCTACAAACAAAGCAGTTCCTTTGGGAGGTTTTTAGTTTGAGTTTTAGCGTGTGTGTGTGTTTGTGTGTGTGCGTGTGCGTG
TGTGTGTGTGTTGGAATTTCCTATCTGCCTGGATATATTAGCAGAGTTTGAATGTAGTTTTGGCCTTTGGCCATTAGACTTCTATTAAAA
TTCATTAATAGTCATACAACCAACATAGAGTTGAATGAGAACTGCCGATGTAATTAATAGGCATGACATCCATTTCAAACATCTCAACAC
TTTAAAGAAAAGCCCTTTGTTTCAAGAAAAAAGGGTTTGTAACTAACTAAATACCTAACATGTAATTGACACTAAAATATGAACTTTGTC
TTATTTAGTTTCTGTTATAGCTGTAAAATTTCAGGCAGAGCCATAACATTGTACAGAGTGTAGCACTTGTGATTAAACCTAGCCTGTTAA
ATCCTGAAACCTTCAACCATTACTTCTGTGAATACTTTAGCCCTGGGATTTGGGTTTTTCTGTTCCGGTGTTGTGTCTGTTGCCGGCAAT
GGACACACCATATCTGCTGCTGGCCCAAGGAACGTCATTAATTTTTCTTTCCAAATTAAGTATTATGTGCTAGTCAGTGTATAGTAAAGC
ACTTCTCTTTTTTATTACTAAAAAGCTGGCATTAGATTTGCATTATAAATACCTCTCTAGGAACTTTATACTCCTTTTCCTTCTTCAACA
GGTATTGCCCTTAAATCTTATCTTTTGGCCTTGAAAGTTTATAGCTATTGTTTTTCAGTTGTTCGTTGTTTTGTTTTGTTTCACTTTAGT
TCTGTAGTACCTGCCCATTAATATTTTTGCTTTGATTCTAGCAATGTGTATGTATCTGTATAAAAAATAAAATAATGAAAGCAACCTAAA
AATAGGATGCACCAATAGCATGTGGTTCCAAGTAAGTTGTGATTTTTATTTTGAGACAGTGTTCCACTGGAAGGGAGGGAAGGGCTTACA
TTCACAGACAGTAAAGCAGGGCTGTGTAAGGAGCTACATTTACTTAACAGTCTCCTTTCCAGCTAGGTTTGTTTTATTTATTTGCAAGTC
AGCTAAGAATTAACCTTTTAAACCATCTAAAACAGGCAAGCAATATAAAGATTTCTACTAGTGCAAGGTAAGTGGTTTGAATATACAAGT
GCCCTTTCCTGCCACCCAGTCTCACTACCGTTTTAGTCCTGCAGCTGGGTAAAGCCACTATTGTGTGGAAACTCTCCCATGTGCCCTGTC
TCTACCTCTGGACACACCAGCTCCTTCTTCCACCTATTCTATTCCTCAGTTAAGCCAAGTGATCAGAAGTAGTATTAAATGGGTAGATAA
TTTTAACAGGATGCCTAATGTGAAATAAGGAGTTATTTTTACTCTTCTACTATAGAAAGCCTAAGGTAATTCTTACCATCTCAAAGACTG
AGTATTCCATTTAGGTTTGGAGACCACTTGTGCTGTGCTGCCTGATATTTACCAAACTTGAATAAGTGTTCGTCAACTTGATAGTGAATG
TACCCCTTCTCACCTTATATTTTGATTAAATCAATTAACTATAGGTCATCTACCAAGAATGTAATCCAAGCGGTTGATAAAACATTATTA
GGCAGATAGATTATTGATTATTAAATTTTGAGCAGTGCAAAAACGGTTTTGCTGCTTGGAGTTCAGATTCAGTCCCTCAAAGAGTTTATG
ATCACTGAAATACACTCTGAAGGTATTCTGAAGAAGTTAAAAAATTTTAGAAAACGAAATGTTCTGTATACAAAGACAATACAGTCACTA
CGAACTGCAGAAAGTATAGGAAAGCAGTAATTGATGTAGAGTTTAGACAGTCTTGGATCTTTTTTAGAGCACTAACCATGGATTTAGACT
CAAAATAGCTGCTACATAATAGAGCCCTTTAATAATTTAAACCCCCCTTGTTGAAATACAAGTTGGACTCCCAGTGTCAAACTCTAGACT
GTAGCTAATGTATTAAAGGGAGATGTAGATTAATATTCAGTATATTTAGTTTGCAATTTCTGAAAAGGTTTGAAAACTAGTCAGCTTTTC
ACACAGCAGAAGCTTTGAACTGAAATATGTGTGAAAAGGACGCAGACTGAAAACGTTTTGGTTTTGTACATCAGTGCTGATGAAATTAGT
GTAAAACATTTTCCATCATTGGCACATTACTGCAAAATGATGGCAGAGATATTTTCAAGAATGTACATCAAGTTATATTTCCTTGACATC
CTTTTTTCAATTGGTCAAGGTTACAGATTCAGAGGATAAAGGGTAGTTTCATTTAGAATAAATTCATGTCTACTGGCAATCTATATATAA
AAGTGACCTGCCCAAGAACCAAAAACTTTAAATGCTAATGAAGCTTTTGAAAAATAATTTTTAAACAAATTAATTTTAAAAGGGTGTTAC
ACGTACCCAGTTTTTACTTTTTAGTTGATGAAACCCATCCTATAATATACATTTGAGCAAAGTACACATATTAAGAAAAACATGGACATT
TACTTGTTTAATAGTCAAAATGATGAGGAAATGTTAGCTGTTTTTAAGTGGGACTGGTGGGGTGTCCTTTGTCACAAGGAATGCTTTTTT
AGCTTGTTTGTGGGCATAAGAGATGTTAACCCTTTGCTGATTCTACCACACAACTGTAAAGAACCTAATGAATCTACAAGTTTAATATTC
AGAAAAAGCTAGGAACTCCGCTCTTTACCAGTACAGTGGAACAGGCCCGTTATTCAAGGTGATGCCTCACAGCTATAGAACAACTATTCA
AAGACCCAGAGTTAAATGGTACATGTGTATATGTGTGTGTGTGTGTGCACACGCACACACTTCAGATAAGTATCAGAAAAAATAAAAATG
AATCCATCATTAACTTGAAAGAAATAAGATGGCTGCATTGCAACAGATACAAATATTATGAACATCATTTAATTACAGAAAATCTAGACA
ACAGTTTCTCCTGATGTTTGACATTCTCAAAATATATTCCTCATTCTCGAAGAAGCAGAGAATGCCAAGGCTGCATATCTGCTGTAATCT
ACCTAGCCCTCTTCTGCTTAATATGATCCATTATTGAATCTTCTCAGATTAAAATCCATTCCTATATCATCTACCTTTCCCAAAGTGTGT
GCCTGTAAACCTACCTTGGAAGTGGCAAGTTAACTGATTTTTTTGTGTCATTTTTATACCAATCCTTAAGGTCAAAGCCTTTTGCTATCA
ATGTATTTAAACTGAGTTGCTATATGTTCACTAATTTGTTTTCAAAATGTTTTGCTCCAACTTAAATTATCTTTTAACATCTTTTGAGTG
CCAAGAATTGCTAAGTAACTGTAATATGTTGAAGAGAGTAATTGCCAAGCAAGCAGTCATAAGCCAAAATGTAATGAGCTTAGTATATAA
CCACTTTAGAGTATACACTCACCACTTTTTGTATTCATTCATGCAAACCCTCCTGGAAGTCGATTAGAAGAGGATCCAATTTGTGGACCT
TTTTTCCTCCTTTTGGACACCTGAGCACAATTTTTTTTTTCCTTTCATATTTATACCACTTTGGAAAATTCAGTAAACCCAATTCTGGCA
CATCATAATGGTTTCAGTTAGTGAAGATGTTTATTTTAATAACTTTAAAATATGACTATCCTATACATAAGTTATATAAGAGGGCATAAC
AATAGATGAGTAGAAATTTATAAAATTTCTTGGATATTTTGAATGAGAAAAAAACATTTTTAAAGGAATTTTGTTTTTTCCTTTTTTGGC
CAAACCGGTACAAGTTAGAAAGTGTGCTAAGGACTGAATACTTGCCTCGTGCTTTTTGCCACTGGATGATGTAAGTTAAGAATGGAATTG
TTAATCCTAAGTATATATTTTCTTGACTTTCATCAGTTTCTAAAGAAATCTAATTTAAGTGTTTTGCGGTTTTGTTTGATCTGTATTTAT
TGAGTTCTGGTCATAGACCAGCAGCTTGCACGTCATGCTCATGAACAGCCAGAACATAGTTATTGGGGAACTTCATGGCTCAAAACCTTC
TGAATCATTTAACTTATTTTGTATGTTGCAAAAAAAAAAAAAAAGTTTATTTTGCTTGAGAGTCACCTTTTTTTAAAAAAAATAACTGTA
CAGCTTTTAAGGGATGGGAGGTGGGAAAATACCCTAAAATAGGATGTAGATTTTTTACAATTGTGTTTATGCTAGATCATCTACAGGTGC
ATTATGTAATTAAACCTAAAATTGTTTAAAAATTTGTGCCATGTCTTTTTCATTCTCCTGCCCTTTAGCAGAATTGGTGCATGTCAACTG
CTATGTGGACAAGCCTTGAAATTAGAGTAACAAGCCCTGTCTCCAAAGCTTTAAGGTCACTGCATGAAAATTGCACACACACACACACAC
ACACACACATCTAGCTTATATTAGTAAATGGATTTTCAGGATCAGAACAGCTACAGTAGCCCAGATTTGGCTGTTAACAGCATATTCTTA
CAGCACATGATTTTTGTGATGCCTAACTAGGGTATTCTCAATGTTAGTCTGGTGTTCTATTCTCTTTCAAAGTAGCTTCTTGAGATGGTA
TCTGTTGTAGCTTGCCCAAACCTGCCATGAGGTTGTGTGTACACTTTGAAAGGGTATGTCCTATGCTAAGATGGTGGTAGAGCAGGGCTT
GATTTTAATCTATTCATATAAAAGAAGGAAAAAACTAGAATTGGTCTATTTGGTTATTCAGTGGACTTAATTCCACAGGAATAGTTGTCT
GCTGAAGCGTGGCAGCAAGAGAAGTCAAATTCAAGTTTCAGTTCCTTCCTTATTCACTAAGTATTTTGAAATCTTGTAGAACTTCTGATT
CTAGCACAGTCTTTTACATGGCACATTTTACCATGGTATATTCACAGCTTCGTTTAAATGTCAGTACTTTTTCCCATCTGATAATTTTGC
CATTCTAATTTCTCACCTTTGTAGTACAAGTGTATTCTTGAAAATAATTAAATTCATCTAAGTGTGTCATAATTTCAATCAAAGCTATAT
TCATGTGTTGCCAGCGTCAGTTTTTTGCTATCCTCATTCAGAAGGGAAGCCTGCAGATCATGAGTTTCCATATGAAGAATACAAATTCCA
CATAAAAATTTATAAATGGTATCTTTAGAATTTTGATTTAAAGTAATAGCTGGAATTCAGGGACTGATCAGAATGCCTCTTGAATTTTCC
AACATGCTTATATGAAATGCTTTATTTTCCTATGCGTTAAAAAAAATATTCCTGGAATAGGTTCTCAGAATGTTTTATTTGGTTTCTAGG
AGATGAGATTTAAAGCAGAAGCTCCAAGATTGGCATAAAACTAACTCTTGAGGTAATCAGGACCATGCTGTTAGTCAAATAGAAGCTGGA
GTGCTCTCTGTCACATAATGTACTGCATGTGTGTGGGGGTGGGGGGGCAGGGAAGATCAGAAAACTGGAAATGTAATTCTGATAACACGC
AAAGTAAATTGTGCATTAAAAGTATGGGAATTCTTGGTAGCTTAAAGCTTCAGGGGTTAACTTCAGTGTATGAACACCTAGTGTGTTAGA
ATTGCAGTGCATAGTTGTTTAAATACAATATTCCTTGTAAGTGACAACCAAAATATGTTGTGGCTGGTGCCAGTATTTTTGTTAATGAAA
TGTTCAGTGTCTCACTACAGTCTGATCAGAACTCTTGGTGTTATAAGCCAGGCCTAAAGCCATTTTATAGCTATTGGCCTAATTGTGTAA
CTTTTTCTTTCAAAATGTTTTATTATAATACTTCTGTCATTTCTTTCACTTAATATGTCAATTGTCATAATAAAAATTTAAATTTGAATT

>57279_57279_1_NARS2-RSF1_NARS2_chr11_78239888_ENST00000281038_RSF1_chr11_77378536_ENST00000308488_length(amino acids)=264AA_BP=
MRKEGRCRRGSNRGVWAAPAEGLGGRGMLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVLFLH
VNDGSSLESLQVVADSGLDSRELNFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDFPIKYKERHPLEYLRQYPHFRCRTNVLG

--------------------------------------------------------------
>57279_57279_2_NARS2-RSF1_NARS2_chr11_78239888_ENST00000281038_RSF1_chr11_77378536_ENST00000360355_length(transcript)=2327nt_BP=1065nt
GTAGCGTGATGACGTAAGCGGCGTTGGCGTGGTGTGGTAGGAGTGGTTGCGCGTGTTGCGGCCCGGGTTCTGTTCGTAGGTTTACAATTG
TCGCGGGTAGTGGGGCGCCCCAGCTGCCAACTGCACGTGGTTTCTTTCTGGCGTTTGCCTAGTGTCCTGTCCATTCCGCCCCGTTGGGAA
GTGGGAAGCGGAGAGGTTCTGTGGGGACAGAGCTGGGAGTCCTGAAGGAGAAAGCGCGCAGCCGAGGGGCTCTGGAGTGCCTTAGAGCAG
AGCTGCGGCCGCGGAAGGGGAGCAGCTGAGAAAGGAGGGCCGCTGCAGGCGGGGTTCGAACCGTGGGGTCTGGGCTGCTCCCGCGGAGGG
CCTGGGCGGACGCGGGATGCTGGGGGTCCGCTGCCTGCTGCGGTCCGTGCGCTTCTGTTCCTCCGCCCCCTTCCCCAAGCACAAACCTTC
AGCCAAACTGAGCGTGCGGGACGCTCTCGGGGCTCAGAACGCGAGTGGGGAGCGCATTAAGATCCAGGGATGGATTCGTTCTGTCCGATC
CCAGAAGGAAGTCTTGTTCCTGCATGTAAATGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGA
ATTAAATTTTGGGAGTTCTGTGGAAGTACAAGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAAT
TAAAGTTATTGGAAATTGTGATGCCAAGGATTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTT
TAGGTGTAGGACTAACGTTCTGGGTTCTATATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTT
TGTACATATTCATACTCCAATAATCACATCCAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGT
ACCTGAGGAGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGAGAGCTATTTGTCCA
AGAACTCTGAAGATGATGAGCTAGCTAAAGAATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATG
AGGAGGAGGAGGAAGAGGAAGGCAAACCATCCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATG
GAGATGCAAATCAGCCTGCCCGTGACAGCCAGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTG
ATGAGGAAGAGGACTTTGAAAATGTAGGCAAAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCC
CTGGCAAAGCCATTGAGAACTTGATTGGCAAGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCT
CCAATGGGACAAGTGGTGGGCAGGAGGCAGGAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCT
GTAACAGTGAACAGTTATAAGACTTTTTTTCCATTTTTGTGCTAATTTATTCCACGGTAGCTCTCACACCAGCGGGCCAGTTATTAAAAG
CTGTTTAATTTTTCCTAGAAAACTCCACTACAGAATGACTTTTAGAAGAAAAATTTCAACAAATCCTGAAGTCTTTCTGTGAAGTGACCA
GTTCTGAACTTTGAAGATAAATAATTGCTGTAAATTCCTTTTGATTTTCTTTTTCCAGGTTCATGGTCCTTGGTAATTTCATTCATGGAA
AAAAATCTTATTATAATAACAACAAAGATTTGTATATTTTTGACTTTATATTTCCTGAGCTCTCCTGACTTTGTGAAAAAGGGTGGATGA
AAATGCATTCCGAATCTGTGAGGGCCCAAAACAGAATTTAGGGGTGGGTGAAAGCACTTGTGCTTTAGCTTTTTCATATTAAATATATAT
TATATTTAAACATTCATGGCATAGATGATGATTTACAGACAATTTAAAAGTTCAAGTCTGTACTGTTACAGTTTGAGAATTGTAGATAAC
ATCATACATAAGTCATTTAGTAACAGCCTTTGTGAAATGAACTTGTTTACTATTGGAGATAACCACACTTAATAAAGAAGAGACAGTGAA

>57279_57279_2_NARS2-RSF1_NARS2_chr11_78239888_ENST00000281038_RSF1_chr11_77378536_ENST00000360355_length(amino acids)=264AA_BP=
MRKEGRCRRGSNRGVWAAPAEGLGGRGMLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVLFLH
VNDGSSLESLQVVADSGLDSRELNFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDFPIKYKERHPLEYLRQYPHFRCRTNVLG

--------------------------------------------------------------
>57279_57279_3_NARS2-RSF1_NARS2_chr11_78239888_ENST00000528850_RSF1_chr11_77378536_ENST00000308488_length(transcript)=8441nt_BP=945nt
AGGGTCTAGCTCTGTCACCCAGACTGGAGCGCAGTGATGTGATCTCAGATGACTACAACCTCCATCTCCCAGGCTCAAGCAATCCTCCTG
CCTCGGCCTCCAGAGTAGCTGAAACTATAGGCATGCACCACCACACTCTATAATTTTTTAAGTTTTTTGTGAAGATGAGTCTCACTGTAT
TGCCCAGGCTGGTCTCAAACTCCTGGACTCAAGCAGTCCTCCTCCTTCGGCATCCCAAAATGCTGGGATTACAGGCATAAGCCTGGTAGA
TGTTGTTATAATAAATACTTATTTTTTGAGTAGGTTCTTGCTTTGTCACCCATGATTGTACTGACACAGTCATGGCTTGCCGTTGCAGTG
ATTTCTGTTGTCCTCACATATCCTTTACTTTTTAGCGGGATGGATTCGTTCTGTCCGATCCCAGAAGGAAGTCTTGTTCCTGCATGTAAA
TGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGAATTAAATTTTGGGAGTTCTGTGGAAGTACA
AGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAATTAAAGTTATTGGAAATTGTGATGCCAAGGA
TTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTTTAGGTGTAGGACTAACGTTCTGGGTTCTAT
ATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTTTGTACATATTCATACTCCAATAATCACATC
CAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGTACCTGAGGAGAATTTCTTCAATGTTCCTGC
TTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGAGAGCTATTTGTCCAAGAACTCTGAAGATGATGAGCTAGCTAAAG
AATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATGAGGAGGAGGAGGAAGAGGAAGGCAAACCAT
CCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATGGAGATGCAAATCAGCCTGCCCGTGACAGCC
AGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTGATGAGGAAGAGGACTTTGAAAATGTAGGCA
AAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCCCTGGCAAAGCCATTGAGAACTTGATTGGCA
AGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCTCCAATGGGACAAGTGGTGGGCAGGAGGCAG
GAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCTGTAACAGTGAACAGTTATAAGACTTTTTTT
CCATTTTTGTGCTAATTTATTCCACGGTAGCTCTCACACCAGCGGGCCAGTTATTAAAAGCTGTTTAATTTTTCCTAGAAAACTCCACTA
CAGAATGACTTTTAGAAGAAAAATTTCAACAAATCCTGAAGTCTTTCTGTGAAGTGACCAGTTCTGAACTTTGAAGATAAATAATTGCTG
TAAATTCCTTTTGATTTTCTTTTTCCAGGTTCATGGTCCTTGGTAATTTCATTCATGGAAAAAAATCTTATTATAATAACAACAAAGATT
TGTATATTTTTGACTTTATATTTCCTGAGCTCTCCTGACTTTGTGAAAAAGGGTGGATGAAAATGCATTCCGAATCTGTGAGGGCCCAAA
ACAGAATTTAGGGGTGGGTGAAAGCACTTGTGCTTTAGCTTTTTCATATTAAATATATATTATATTTAAACATTCATGGCATAGATGATG
ATTTACAGACAATTTAAAAGTTCAAGTCTGTACTGTTACAGTTTGAGAATTGTAGATAACATCATACATAAGTCATTTAGTAACAGCCTT
TGTGAAATGAACTTGTTTACTATTGGAGATAACCACACTTAATAAAGAAGAGACAGTGAAAGTACCATCATAATTAACCTAAATTTTTGT
TATAGCAGAGTTTCTTGTTTAAAAAAAAATAAAATCATCTGAAAAGCATTTGTACAGTAAAATGTATAATGAAGCTTTGCCAACCAGACT
GTGCTAGCAACAAATTTTTTTAAATAAGCTTTATGCAGTGGTAATAAGGTGGCCTCAAATATATTGTGTCTGATGGAGAGTTATTAGTGA
AATGAATGTGGTCTTTCTTAAGGCCTGGGTGGACTGTAAACTTTGCCAATAGTATAACTCTTGTCTTCTGGCCACTTGATGTTTAAATAT
CTGAAATATCATTTTGAAAAAAATACATCTATATATAACATACATGAAGAGATGCTAAGCTGACAGTGATATTTTAGCACATTTGAAGAC
TGGGAAGAGATTTTCAGGTGAATTTTAACTGGTCTATTCTTGCCCTTAGTATCTACTTCAAATTGAAGTCTACAAACAAAGCAGTTCCTT
TGGGAGGTTTTTAGTTTGAGTTTTAGCGTGTGTGTGTGTTTGTGTGTGTGCGTGTGCGTGTGTGTGTGTGTTGGAATTTCCTATCTGCCT
GGATATATTAGCAGAGTTTGAATGTAGTTTTGGCCTTTGGCCATTAGACTTCTATTAAAATTCATTAATAGTCATACAACCAACATAGAG
TTGAATGAGAACTGCCGATGTAATTAATAGGCATGACATCCATTTCAAACATCTCAACACTTTAAAGAAAAGCCCTTTGTTTCAAGAAAA
AAGGGTTTGTAACTAACTAAATACCTAACATGTAATTGACACTAAAATATGAACTTTGTCTTATTTAGTTTCTGTTATAGCTGTAAAATT
TCAGGCAGAGCCATAACATTGTACAGAGTGTAGCACTTGTGATTAAACCTAGCCTGTTAAATCCTGAAACCTTCAACCATTACTTCTGTG
AATACTTTAGCCCTGGGATTTGGGTTTTTCTGTTCCGGTGTTGTGTCTGTTGCCGGCAATGGACACACCATATCTGCTGCTGGCCCAAGG
AACGTCATTAATTTTTCTTTCCAAATTAAGTATTATGTGCTAGTCAGTGTATAGTAAAGCACTTCTCTTTTTTATTACTAAAAAGCTGGC
ATTAGATTTGCATTATAAATACCTCTCTAGGAACTTTATACTCCTTTTCCTTCTTCAACAGGTATTGCCCTTAAATCTTATCTTTTGGCC
TTGAAAGTTTATAGCTATTGTTTTTCAGTTGTTCGTTGTTTTGTTTTGTTTCACTTTAGTTCTGTAGTACCTGCCCATTAATATTTTTGC
TTTGATTCTAGCAATGTGTATGTATCTGTATAAAAAATAAAATAATGAAAGCAACCTAAAAATAGGATGCACCAATAGCATGTGGTTCCA
AGTAAGTTGTGATTTTTATTTTGAGACAGTGTTCCACTGGAAGGGAGGGAAGGGCTTACATTCACAGACAGTAAAGCAGGGCTGTGTAAG
GAGCTACATTTACTTAACAGTCTCCTTTCCAGCTAGGTTTGTTTTATTTATTTGCAAGTCAGCTAAGAATTAACCTTTTAAACCATCTAA
AACAGGCAAGCAATATAAAGATTTCTACTAGTGCAAGGTAAGTGGTTTGAATATACAAGTGCCCTTTCCTGCCACCCAGTCTCACTACCG
TTTTAGTCCTGCAGCTGGGTAAAGCCACTATTGTGTGGAAACTCTCCCATGTGCCCTGTCTCTACCTCTGGACACACCAGCTCCTTCTTC
CACCTATTCTATTCCTCAGTTAAGCCAAGTGATCAGAAGTAGTATTAAATGGGTAGATAATTTTAACAGGATGCCTAATGTGAAATAAGG
AGTTATTTTTACTCTTCTACTATAGAAAGCCTAAGGTAATTCTTACCATCTCAAAGACTGAGTATTCCATTTAGGTTTGGAGACCACTTG
TGCTGTGCTGCCTGATATTTACCAAACTTGAATAAGTGTTCGTCAACTTGATAGTGAATGTACCCCTTCTCACCTTATATTTTGATTAAA
TCAATTAACTATAGGTCATCTACCAAGAATGTAATCCAAGCGGTTGATAAAACATTATTAGGCAGATAGATTATTGATTATTAAATTTTG
AGCAGTGCAAAAACGGTTTTGCTGCTTGGAGTTCAGATTCAGTCCCTCAAAGAGTTTATGATCACTGAAATACACTCTGAAGGTATTCTG
AAGAAGTTAAAAAATTTTAGAAAACGAAATGTTCTGTATACAAAGACAATACAGTCACTACGAACTGCAGAAAGTATAGGAAAGCAGTAA
TTGATGTAGAGTTTAGACAGTCTTGGATCTTTTTTAGAGCACTAACCATGGATTTAGACTCAAAATAGCTGCTACATAATAGAGCCCTTT
AATAATTTAAACCCCCCTTGTTGAAATACAAGTTGGACTCCCAGTGTCAAACTCTAGACTGTAGCTAATGTATTAAAGGGAGATGTAGAT
TAATATTCAGTATATTTAGTTTGCAATTTCTGAAAAGGTTTGAAAACTAGTCAGCTTTTCACACAGCAGAAGCTTTGAACTGAAATATGT
GTGAAAAGGACGCAGACTGAAAACGTTTTGGTTTTGTACATCAGTGCTGATGAAATTAGTGTAAAACATTTTCCATCATTGGCACATTAC
TGCAAAATGATGGCAGAGATATTTTCAAGAATGTACATCAAGTTATATTTCCTTGACATCCTTTTTTCAATTGGTCAAGGTTACAGATTC
AGAGGATAAAGGGTAGTTTCATTTAGAATAAATTCATGTCTACTGGCAATCTATATATAAAAGTGACCTGCCCAAGAACCAAAAACTTTA
AATGCTAATGAAGCTTTTGAAAAATAATTTTTAAACAAATTAATTTTAAAAGGGTGTTACACGTACCCAGTTTTTACTTTTTAGTTGATG
AAACCCATCCTATAATATACATTTGAGCAAAGTACACATATTAAGAAAAACATGGACATTTACTTGTTTAATAGTCAAAATGATGAGGAA
ATGTTAGCTGTTTTTAAGTGGGACTGGTGGGGTGTCCTTTGTCACAAGGAATGCTTTTTTAGCTTGTTTGTGGGCATAAGAGATGTTAAC
CCTTTGCTGATTCTACCACACAACTGTAAAGAACCTAATGAATCTACAAGTTTAATATTCAGAAAAAGCTAGGAACTCCGCTCTTTACCA
GTACAGTGGAACAGGCCCGTTATTCAAGGTGATGCCTCACAGCTATAGAACAACTATTCAAAGACCCAGAGTTAAATGGTACATGTGTAT
ATGTGTGTGTGTGTGTGCACACGCACACACTTCAGATAAGTATCAGAAAAAATAAAAATGAATCCATCATTAACTTGAAAGAAATAAGAT
GGCTGCATTGCAACAGATACAAATATTATGAACATCATTTAATTACAGAAAATCTAGACAACAGTTTCTCCTGATGTTTGACATTCTCAA
AATATATTCCTCATTCTCGAAGAAGCAGAGAATGCCAAGGCTGCATATCTGCTGTAATCTACCTAGCCCTCTTCTGCTTAATATGATCCA
TTATTGAATCTTCTCAGATTAAAATCCATTCCTATATCATCTACCTTTCCCAAAGTGTGTGCCTGTAAACCTACCTTGGAAGTGGCAAGT
TAACTGATTTTTTTGTGTCATTTTTATACCAATCCTTAAGGTCAAAGCCTTTTGCTATCAATGTATTTAAACTGAGTTGCTATATGTTCA
CTAATTTGTTTTCAAAATGTTTTGCTCCAACTTAAATTATCTTTTAACATCTTTTGAGTGCCAAGAATTGCTAAGTAACTGTAATATGTT
GAAGAGAGTAATTGCCAAGCAAGCAGTCATAAGCCAAAATGTAATGAGCTTAGTATATAACCACTTTAGAGTATACACTCACCACTTTTT
GTATTCATTCATGCAAACCCTCCTGGAAGTCGATTAGAAGAGGATCCAATTTGTGGACCTTTTTTCCTCCTTTTGGACACCTGAGCACAA
TTTTTTTTTTCCTTTCATATTTATACCACTTTGGAAAATTCAGTAAACCCAATTCTGGCACATCATAATGGTTTCAGTTAGTGAAGATGT
TTATTTTAATAACTTTAAAATATGACTATCCTATACATAAGTTATATAAGAGGGCATAACAATAGATGAGTAGAAATTTATAAAATTTCT
TGGATATTTTGAATGAGAAAAAAACATTTTTAAAGGAATTTTGTTTTTTCCTTTTTTGGCCAAACCGGTACAAGTTAGAAAGTGTGCTAA
GGACTGAATACTTGCCTCGTGCTTTTTGCCACTGGATGATGTAAGTTAAGAATGGAATTGTTAATCCTAAGTATATATTTTCTTGACTTT
CATCAGTTTCTAAAGAAATCTAATTTAAGTGTTTTGCGGTTTTGTTTGATCTGTATTTATTGAGTTCTGGTCATAGACCAGCAGCTTGCA
CGTCATGCTCATGAACAGCCAGAACATAGTTATTGGGGAACTTCATGGCTCAAAACCTTCTGAATCATTTAACTTATTTTGTATGTTGCA
AAAAAAAAAAAAAAGTTTATTTTGCTTGAGAGTCACCTTTTTTTAAAAAAAATAACTGTACAGCTTTTAAGGGATGGGAGGTGGGAAAAT
ACCCTAAAATAGGATGTAGATTTTTTACAATTGTGTTTATGCTAGATCATCTACAGGTGCATTATGTAATTAAACCTAAAATTGTTTAAA
AATTTGTGCCATGTCTTTTTCATTCTCCTGCCCTTTAGCAGAATTGGTGCATGTCAACTGCTATGTGGACAAGCCTTGAAATTAGAGTAA
CAAGCCCTGTCTCCAAAGCTTTAAGGTCACTGCATGAAAATTGCACACACACACACACACACACACACATCTAGCTTATATTAGTAAATG
GATTTTCAGGATCAGAACAGCTACAGTAGCCCAGATTTGGCTGTTAACAGCATATTCTTACAGCACATGATTTTTGTGATGCCTAACTAG
GGTATTCTCAATGTTAGTCTGGTGTTCTATTCTCTTTCAAAGTAGCTTCTTGAGATGGTATCTGTTGTAGCTTGCCCAAACCTGCCATGA
GGTTGTGTGTACACTTTGAAAGGGTATGTCCTATGCTAAGATGGTGGTAGAGCAGGGCTTGATTTTAATCTATTCATATAAAAGAAGGAA
AAAACTAGAATTGGTCTATTTGGTTATTCAGTGGACTTAATTCCACAGGAATAGTTGTCTGCTGAAGCGTGGCAGCAAGAGAAGTCAAAT
TCAAGTTTCAGTTCCTTCCTTATTCACTAAGTATTTTGAAATCTTGTAGAACTTCTGATTCTAGCACAGTCTTTTACATGGCACATTTTA
CCATGGTATATTCACAGCTTCGTTTAAATGTCAGTACTTTTTCCCATCTGATAATTTTGCCATTCTAATTTCTCACCTTTGTAGTACAAG
TGTATTCTTGAAAATAATTAAATTCATCTAAGTGTGTCATAATTTCAATCAAAGCTATATTCATGTGTTGCCAGCGTCAGTTTTTTGCTA
TCCTCATTCAGAAGGGAAGCCTGCAGATCATGAGTTTCCATATGAAGAATACAAATTCCACATAAAAATTTATAAATGGTATCTTTAGAA
TTTTGATTTAAAGTAATAGCTGGAATTCAGGGACTGATCAGAATGCCTCTTGAATTTTCCAACATGCTTATATGAAATGCTTTATTTTCC
TATGCGTTAAAAAAAATATTCCTGGAATAGGTTCTCAGAATGTTTTATTTGGTTTCTAGGAGATGAGATTTAAAGCAGAAGCTCCAAGAT
TGGCATAAAACTAACTCTTGAGGTAATCAGGACCATGCTGTTAGTCAAATAGAAGCTGGAGTGCTCTCTGTCACATAATGTACTGCATGT
GTGTGGGGGTGGGGGGGCAGGGAAGATCAGAAAACTGGAAATGTAATTCTGATAACACGCAAAGTAAATTGTGCATTAAAAGTATGGGAA
TTCTTGGTAGCTTAAAGCTTCAGGGGTTAACTTCAGTGTATGAACACCTAGTGTGTTAGAATTGCAGTGCATAGTTGTTTAAATACAATA
TTCCTTGTAAGTGACAACCAAAATATGTTGTGGCTGGTGCCAGTATTTTTGTTAATGAAATGTTCAGTGTCTCACTACAGTCTGATCAGA
ACTCTTGGTGTTATAAGCCAGGCCTAAAGCCATTTTATAGCTATTGGCCTAATTGTGTAACTTTTTCTTTCAAAATGTTTTATTATAATA

>57279_57279_3_NARS2-RSF1_NARS2_chr11_78239888_ENST00000528850_RSF1_chr11_77378536_ENST00000308488_length(amino acids)=201AA_BP=
MLSSHILYFLAGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSGLDSRELNFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDF
PIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHTPIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAF

--------------------------------------------------------------
>57279_57279_4_NARS2-RSF1_NARS2_chr11_78239888_ENST00000528850_RSF1_chr11_77378536_ENST00000360355_length(transcript)=2207nt_BP=945nt
AGGGTCTAGCTCTGTCACCCAGACTGGAGCGCAGTGATGTGATCTCAGATGACTACAACCTCCATCTCCCAGGCTCAAGCAATCCTCCTG
CCTCGGCCTCCAGAGTAGCTGAAACTATAGGCATGCACCACCACACTCTATAATTTTTTAAGTTTTTTGTGAAGATGAGTCTCACTGTAT
TGCCCAGGCTGGTCTCAAACTCCTGGACTCAAGCAGTCCTCCTCCTTCGGCATCCCAAAATGCTGGGATTACAGGCATAAGCCTGGTAGA
TGTTGTTATAATAAATACTTATTTTTTGAGTAGGTTCTTGCTTTGTCACCCATGATTGTACTGACACAGTCATGGCTTGCCGTTGCAGTG
ATTTCTGTTGTCCTCACATATCCTTTACTTTTTAGCGGGATGGATTCGTTCTGTCCGATCCCAGAAGGAAGTCTTGTTCCTGCATGTAAA
TGATGGGTCATCTTTGGAAAGCCTTCAGGTTGTTGCAGATTCAGGCCTTGACAGTAGAGAATTAAATTTTGGGAGTTCTGTGGAAGTACA
AGGGCAGCTGATAAAAAGTCCATCCAAAAGGCAAAATGTGGAACTGAAGGCAGAAAAAATTAAAGTTATTGGAAATTGTGATGCCAAGGA
TTTCCCCATCAAATATAAAGAGAGGCATCCTCTGGAGTATCTGCGACAATATCCTCACTTTAGGTGTAGGACTAACGTTCTGGGTTCTAT
ATTGAGGATTCGCAGTGAAGCGACAGCTGCTATTCATTCTTTCTTTAAGGACAGTGGCTTTGTACATATTCATACTCCAATAATCACATC
CAATGACTCTGAGGGAGCTGGAGAACTTTTTCAACTTGAACCTTCAGGCAAACTTAAGGTACCTGAGGAGAATTTCTTCAATGTTCCTGC
TTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGAGAGCTATTTGTCCAAGAACTCTGAAGATGATGAGCTAGCTAAAG
AATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATGAGGAGGAGGAGGAAGAGGAAGGCAAACCAT
CCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATGGAGATGCAAATCAGCCTGCCCGTGACAGCC
AGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTGATGAGGAAGAGGACTTTGAAAATGTAGGCA
AAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCCCTGGCAAAGCCATTGAGAACTTGATTGGCA
AGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCTCCAATGGGACAAGTGGTGGGCAGGAGGCAG
GAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCTGTAACAGTGAACAGTTATAAGACTTTTTTT
CCATTTTTGTGCTAATTTATTCCACGGTAGCTCTCACACCAGCGGGCCAGTTATTAAAAGCTGTTTAATTTTTCCTAGAAAACTCCACTA
CAGAATGACTTTTAGAAGAAAAATTTCAACAAATCCTGAAGTCTTTCTGTGAAGTGACCAGTTCTGAACTTTGAAGATAAATAATTGCTG
TAAATTCCTTTTGATTTTCTTTTTCCAGGTTCATGGTCCTTGGTAATTTCATTCATGGAAAAAAATCTTATTATAATAACAACAAAGATT
TGTATATTTTTGACTTTATATTTCCTGAGCTCTCCTGACTTTGTGAAAAAGGGTGGATGAAAATGCATTCCGAATCTGTGAGGGCCCAAA
ACAGAATTTAGGGGTGGGTGAAAGCACTTGTGCTTTAGCTTTTTCATATTAAATATATATTATATTTAAACATTCATGGCATAGATGATG
ATTTACAGACAATTTAAAAGTTCAAGTCTGTACTGTTACAGTTTGAGAATTGTAGATAACATCATACATAAGTCATTTAGTAACAGCCTT
TGTGAAATGAACTTGTTTACTATTGGAGATAACCACACTTAATAAAGAAGAGACAGTGAAAGTACCATCATAATTAACCTAAATTTTTGT

>57279_57279_4_NARS2-RSF1_NARS2_chr11_78239888_ENST00000528850_RSF1_chr11_77378536_ENST00000360355_length(amino acids)=201AA_BP=
MLSSHILYFLAGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSGLDSRELNFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDF
PIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHTPIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAF

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Fusion Gene PPI Analysis for NARS2-RSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NARS2-RSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NARS2-RSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource