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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NASP-LUC7L3 (FusionGDB2 ID:57300)

Fusion Gene Summary for NASP-LUC7L3

check button Fusion gene summary
Fusion gene informationFusion gene name: NASP-LUC7L3
Fusion gene ID: 57300
HgeneTgene
Gene symbol

NASP

LUC7L3

Gene ID

4678

51747

Gene namenuclear autoantigenic sperm proteinLUC7 like 3 pre-mRNA splicing factor
SynonymsFLB7527|HMDRA1|PRO1999CRA|CREAP-1|CROP|LUC7A|OA48-18|hLuc7A
Cytomap

1p34.1

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear autoantigenic sperm proteinNASP histone chaperonehistone H1-binding proteinnuclear autoantigenic sperm protein (histone-binding)luc7-like protein 3CRE-associated protein 1LUC7-like 3cAMP regulatory element-associated protein 1cisplatin resistance-associated-overexpressed proteinokadaic acid-inducible phosphoprotein OA48-18
Modification date2020031320200313
UniProtAcc.

O95232

Ensembl transtripts involved in fusion geneENST00000350030, ENST00000351223, 
ENST00000372052, ENST00000402363, 
ENST00000537798, ENST00000530073, 
ENST00000240304, ENST00000311571, 
ENST00000503798, ENST00000544170, 
ENST00000393227, ENST00000505658, 
Fusion gene scores* DoF score9 X 9 X 5=4058 X 8 X 5=320
# samples 99
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NASP [Title/Abstract] AND LUC7L3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNASP(46072218)-LUC7L3(48823182), # samples:1
Anticipated loss of major functional domain due to fusion event.NASP-LUC7L3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NASP-LUC7L3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NASP-LUC7L3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNASP

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

HgeneNASP

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check buttonFusion gene breakpoints across NASP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LUC7L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN266771NASPchr1

46072218

+LUC7L3chr17

48823182

+


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Fusion Gene ORF analysis for NASP-LUC7L3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000350030ENST00000240304NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000350030ENST00000311571NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000350030ENST00000503798NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000350030ENST00000544170NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000351223ENST00000240304NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000351223ENST00000311571NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000351223ENST00000503798NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000351223ENST00000544170NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000372052ENST00000240304NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000372052ENST00000311571NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000372052ENST00000503798NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000372052ENST00000544170NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000402363ENST00000240304NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000402363ENST00000311571NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000402363ENST00000503798NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000402363ENST00000544170NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000537798ENST00000240304NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000537798ENST00000311571NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000537798ENST00000503798NASPchr1

46072218

+LUC7L3chr17

48823182

+
5CDS-intronENST00000537798ENST00000544170NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000350030ENST00000393227NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000350030ENST00000505658NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000351223ENST00000393227NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000351223ENST00000505658NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000372052ENST00000393227NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000372052ENST00000505658NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000402363ENST00000393227NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000402363ENST00000505658NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000537798ENST00000393227NASPchr1

46072218

+LUC7L3chr17

48823182

+
Frame-shiftENST00000537798ENST00000505658NASPchr1

46072218

+LUC7L3chr17

48823182

+
intron-3CDSENST00000530073ENST00000393227NASPchr1

46072218

+LUC7L3chr17

48823182

+
intron-3CDSENST00000530073ENST00000505658NASPchr1

46072218

+LUC7L3chr17

48823182

+
intron-intronENST00000530073ENST00000240304NASPchr1

46072218

+LUC7L3chr17

48823182

+
intron-intronENST00000530073ENST00000311571NASPchr1

46072218

+LUC7L3chr17

48823182

+
intron-intronENST00000530073ENST00000503798NASPchr1

46072218

+LUC7L3chr17

48823182

+
intron-intronENST00000530073ENST00000544170NASPchr1

46072218

+LUC7L3chr17

48823182

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NASP-LUC7L3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NASP-LUC7L3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46072218/:48823182)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LUC7L3

O95232

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NASP-LUC7L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NASP-LUC7L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NASP-LUC7L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NASP-LUC7L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource