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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NASP-NOP56 (FusionGDB2 ID:57301)

Fusion Gene Summary for NASP-NOP56

check button Fusion gene summary
Fusion gene informationFusion gene name: NASP-NOP56
Fusion gene ID: 57301
HgeneTgene
Gene symbol

NASP

NOP56

Gene ID

4678

10528

Gene namenuclear autoantigenic sperm proteinNOP56 ribonucleoprotein
SynonymsFLB7527|HMDRA1|PRO1999NOL5A|SCA36
Cytomap

1p34.1

20p13

Type of geneprotein-codingprotein-coding
Descriptionnuclear autoantigenic sperm proteinNASP histone chaperonehistone H1-binding proteinnuclear autoantigenic sperm protein (histone-binding)nucleolar protein 56NOP56 ribonucleoprotein homolognucleolar protein 5A (56kDa with KKE/D repeat)
Modification date2020031320200313
UniProtAcc.

O00567

Ensembl transtripts involved in fusion geneENST00000350030, ENST00000351223, 
ENST00000372052, ENST00000402363, 
ENST00000537798, ENST00000530073, 
ENST00000492135, ENST00000329276, 
Fusion gene scores* DoF score9 X 9 X 5=4056 X 5 X 1=30
# samples 96
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NASP [Title/Abstract] AND NOP56 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNASP(46072216)-NOP56(2637494), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNASP

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

HgeneNASP

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check buttonFusion gene breakpoints across NASP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOP56 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN266780NASPchr1

46072216

+NOP56chr20

2637494

+


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Fusion Gene ORF analysis for NASP-NOP56

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000350030ENST00000492135NASPchr1

46072216

+NOP56chr20

2637494

+
5CDS-3UTRENST00000351223ENST00000492135NASPchr1

46072216

+NOP56chr20

2637494

+
5CDS-3UTRENST00000372052ENST00000492135NASPchr1

46072216

+NOP56chr20

2637494

+
5CDS-3UTRENST00000402363ENST00000492135NASPchr1

46072216

+NOP56chr20

2637494

+
5CDS-3UTRENST00000537798ENST00000492135NASPchr1

46072216

+NOP56chr20

2637494

+
In-frameENST00000350030ENST00000329276NASPchr1

46072216

+NOP56chr20

2637494

+
In-frameENST00000351223ENST00000329276NASPchr1

46072216

+NOP56chr20

2637494

+
In-frameENST00000372052ENST00000329276NASPchr1

46072216

+NOP56chr20

2637494

+
In-frameENST00000402363ENST00000329276NASPchr1

46072216

+NOP56chr20

2637494

+
In-frameENST00000537798ENST00000329276NASPchr1

46072216

+NOP56chr20

2637494

+
intron-3CDSENST00000530073ENST00000329276NASPchr1

46072216

+NOP56chr20

2637494

+
intron-3UTRENST00000530073ENST00000492135NASPchr1

46072216

+NOP56chr20

2637494

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402363NASPchr146072216+ENST00000329276NOP56chr202637494+1171521131071352
ENST00000537798NASPchr146072216+ENST00000329276NOP56chr202637494+90625648806252
ENST00000350030NASPchr146072216+ENST00000329276NOP56chr202637494+108343333983316
ENST00000372052NASPchr146072216+ENST00000329276NOP56chr202637494+99934930899289
ENST00000351223NASPchr146072216+ENST00000329276NOP56chr202637494+107842828978316

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402363ENST00000329276NASPchr146072216+NOP56chr202637494+0.0056317420.99436826
ENST00000537798ENST00000329276NASPchr146072216+NOP56chr202637494+0.0027544950.99724555
ENST00000350030ENST00000329276NASPchr146072216+NOP56chr202637494+0.0018598450.9981401
ENST00000372052ENST00000329276NASPchr146072216+NOP56chr202637494+0.0019084740.9980915
ENST00000351223ENST00000329276NASPchr146072216+NOP56chr202637494+0.0018311980.9981688

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Fusion Genomic Features for NASP-NOP56


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NASP-NOP56


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:46072216/chr20:2637494)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NOP56

O00567

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNOP56chr1:46072216chr20:2637494ENST00000329276012438_5890595.0Compositional biasNote=Lys-rich
TgeneNOP56chr1:46072216chr20:2637494ENST00000329276012292_4100595.0DomainNop

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115136_1640789.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115460_4870789.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115597_6650789.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115753_7780789.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114136_1640450.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114460_4870450.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114597_6650450.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114753_7780450.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116136_1640791.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116460_4870791.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116597_6650791.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116753_7780791.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113136_1640725.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113460_4870725.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113597_6650725.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113753_7780725.0Coiled coilOntology_term=ECO:0000255
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115111_6580789.0Compositional biasNote=Glu-rich (acidic)
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114111_6580450.0Compositional biasNote=Glu-rich (acidic)
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116111_6580791.0Compositional biasNote=Glu-rich (acidic)
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113111_6580725.0Compositional biasNote=Glu-rich (acidic)
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115716_7220789.0MotifNuclear localization signal
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114716_7220450.0MotifNuclear localization signal
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116716_7220791.0MotifNuclear localization signal
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113716_7220725.0MotifNuclear localization signal
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115116_1270789.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115211_2440789.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115469_5120789.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114116_1270450.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114211_2440450.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114469_5120450.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116116_1270791.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116211_2440791.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116469_5120791.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113116_1270725.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113211_2440725.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113469_5120725.0RegionHistone-binding
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+11543_760789.0RepeatNote=TPR 1
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115542_5750789.0RepeatNote=TPR 2
HgeneNASPchr1:46072216chr20:2637494ENST00000350030+115584_6170789.0RepeatNote=TPR 3
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+11443_760450.0RepeatNote=TPR 1
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114542_5750450.0RepeatNote=TPR 2
HgeneNASPchr1:46072216chr20:2637494ENST00000351223+114584_6170450.0RepeatNote=TPR 3
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+11643_760791.0RepeatNote=TPR 1
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116542_5750791.0RepeatNote=TPR 2
HgeneNASPchr1:46072216chr20:2637494ENST00000402363+116584_6170791.0RepeatNote=TPR 3
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+11343_760725.0RepeatNote=TPR 1
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113542_5750725.0RepeatNote=TPR 2
HgeneNASPchr1:46072216chr20:2637494ENST00000537798+113584_6170725.0RepeatNote=TPR 3


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Fusion Gene Sequence for NASP-NOP56


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57301_57301_1_NASP-NOP56_NASP_chr1_46072216_ENST00000350030_NOP56_chr20_2637494_ENST00000329276_length(transcript)=1083nt_BP=433nt
GTCCCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCACCTCAGGGGAACGATG
GCCATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCTCCTTCTACATCTGCA
GATAAAGTGGAGAGTCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCA
GCTGTCAATGCATTCCAGGAAGCAGCTAGTCTTTTAGGTAAGAAGTATGGAGAGACAGCTAATGAGTGTGGAGAAGCCTTCTTTTTCTAT
GGGAAATCACTTCTGGAGTTGGCAAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAGAAT
CTGGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGCTTA
AAGAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGTGAA
AAACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCCAAG
AAAAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAGTCT
ACACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAGCCG
GTCAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAATGCA
AATGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAATTCACA

>57301_57301_1_NASP-NOP56_NASP_chr1_46072216_ENST00000350030_NOP56_chr20_2637494_ENST00000329276_length(amino acids)=316AA_BP=133
MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL
LGKKYGETANECGEAFFFYGKSLLELARKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALA
LASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPE

--------------------------------------------------------------
>57301_57301_2_NASP-NOP56_NASP_chr1_46072216_ENST00000351223_NOP56_chr20_2637494_ENST00000329276_length(transcript)=1078nt_BP=428nt
TGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCACCTCAGGGGAACGATGGCCAT
GGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCTCCTTCTACATCTGCAGATAA
AGTGGAGAGTCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCAGCTGT
CAATGCATTCCAGGAAGCAGCTAGTCTTTTAGGTAAGAAGTATGGAGAGACAGCTAATGAGTGTGGAGAAGCCTTCTTTTTCTATGGGAA
ATCACTTCTGGAGTTGGCAAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAGAATCTGGA
TGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGCTTAAAGAA
GGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGTGAAAAACC
CAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCCAAGAAAAA
GAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAGTCTACACC
CAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAGCCGGTCAG
CAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAATGCAAATGG

>57301_57301_2_NASP-NOP56_NASP_chr1_46072216_ENST00000351223_NOP56_chr20_2637494_ENST00000329276_length(amino acids)=316AA_BP=133
MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL
LGKKYGETANECGEAFFFYGKSLLELARKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALA
LASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPE

--------------------------------------------------------------
>57301_57301_3_NASP-NOP56_NASP_chr1_46072216_ENST00000372052_NOP56_chr20_2637494_ENST00000329276_length(transcript)=999nt_BP=349nt
CCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCACCTCAGGGGAACGATGGCC
ATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCTCCTTCTACATCTGCAGAT
AAAGTGGAGAGTCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCAGCT
GTCAATGCATTCCAGGAAGCAGCTAGTCTTTTAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGA
AAGAATCTGGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAA
CGCTTAAAGAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATG
AGTGAAAAACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAA
CCCAAGAAAAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAG
AAGTCTACACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAG
GAGCCGGTCAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAG
AATGCAAATGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAA

>57301_57301_3_NASP-NOP56_NASP_chr1_46072216_ENST00000372052_NOP56_chr20_2637494_ENST00000329276_length(amino acids)=289AA_BP=106
MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASL
LKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQ
KPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPEEAGHRSGSKKKRKFSKEEPVSSGPEEA

--------------------------------------------------------------
>57301_57301_4_NASP-NOP56_NASP_chr1_46072216_ENST00000402363_NOP56_chr20_2637494_ENST00000329276_length(transcript)=1171nt_BP=521nt
AATCTGCCATTTTCTGTCCCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCAC
CTCAGGGGAACGATGGCCATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCT
CCTTCTACATCTGCAGATAAAGTGGAGAGCAACCATTAATCTGCTTTCTGTCACTGAAGATGGGTTGCATTTTGTAGAATATTATCTAAA
TAGAATCATACATCTGGATGTGGATAGTGAAGCTAAGAAACTATTGGGTTTAGGACAGAAACATCTGGTGATGGGGGATATTCCAGCAGC
TGTCAATGCATTCCAGGAAGCAGCTAGTCTTTTAGGTAAGAAGTATGGAGAGACAGCTAATGAGTGTGGAGAAGCCTTCTTTTTCTATGG
GAAATCACTTCTGGAGTTGGCAAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAGAATCT
GGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGCTTAAA
GAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGTGAAAA
ACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCCAAGAA
AAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAGTCTAC
ACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAGCCGGT
CAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAATGCAAA
TGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAATTCACAAG

>57301_57301_4_NASP-NOP56_NASP_chr1_46072216_ENST00000402363_NOP56_chr20_2637494_ENST00000329276_length(amino acids)=352AA_BP=169
MSLSESLASQIACFSRRLYSVRWFATSGERWPWSPQPLPPSPRSWFLPTKLKMFLLLLHLQIKWRATINLLSVTEDGLHFVEYYLNRIIH
LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARKTEDESLVENNDNIDEIPRKNLDVMK
EAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSF

--------------------------------------------------------------
>57301_57301_5_NASP-NOP56_NASP_chr1_46072216_ENST00000537798_NOP56_chr20_2637494_ENST00000329276_length(transcript)=906nt_BP=256nt
AATCTGCCATTTTCTGTCCCTGAGTGAGTCTCTGGCGTCCCAAATTGCCTGTTTTTCTCGCAGGCTCTATTCCGTTCGCTGGTTCGCCAC
CTCAGGGGAACGATGGCCATGGAGTCCACAGCCACTGCCGCCGTCGCCGCGGAGCTGGTTTCTGCCGACAAAATTGAAGATGTTCCTGCT
CCTTCTACATCTGCAGATAAAGTGGAGAGAAAAACAGAAGATGAATCTCTGGTAGAAAATAATGATAACATAGATGAGATACCACGAAAG
AATCTGGATGTCATGAAGGAAGCAATGGTTCAGGCAGAGGAAGCGGCTGCTGAGATTACTAGGAAGCTGGAGAAACAGGAGAAGAAACGC
TTAAAGAAGGAAAAGAAACGGCTGGCTGCACTTGCCCTCGCGTCTTCAGAAAACAGCAGTAGTACTCCAGAGGAGTGTGAGGAGATGAGT
GAAAAACCCAAAAAGAAGAAAAAGCAAAAGCCCCAGGAGGTTCCTCAGGAGAATGGAATGGAAGACCCATCTATCTCTTTCTCCAAACCC
AAGAAAAAGAAATCTTTTTCCAAGGAGGAGTTGATGAGTAGCGATCTTGAAGAGACCGCTGGCAGCACCAGTATTCCCAAGAGGAAGAAG
TCTACACCCAAGGAGGAAACAGTTAATGACCCTGAGGAGGCAGGCCACAGAAGTGGCTCCAAGAAAAAGAGGAAATTCTCCAAAGAGGAG
CCGGTCAGCAGTGGGCCTGAAGAGGCGGTTGGCAAGAGCAGCTCCAAGAAGAAGAAAAAGTTCCATAAAGCATCCCAGGAAGATTAGAAT
GCAAATGGACATTCTCTGGGAGGTGGGGCATACCATAGCCCAAGGTGACATTTCCCACCCTGTGCCGTGTTCCCCAATAAAAACAAATTC

>57301_57301_5_NASP-NOP56_NASP_chr1_46072216_ENST00000537798_NOP56_chr20_2637494_ENST00000329276_length(amino acids)=252AA_BP=69
MFFSQALFRSLVRHLRGTMAMESTATAAVAAELVSADKIEDVPAPSTSADKVERKTEDESLVENNDNIDEIPRKNLDVMKEAMVQAEEAA
AEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDL

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Fusion Gene PPI Analysis for NASP-NOP56


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NASP-NOP56


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NASP-NOP56


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource