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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAT8L-DBNDD1 (FusionGDB2 ID:57316)

Fusion Gene Summary for NAT8L-DBNDD1

check button Fusion gene summary
Fusion gene informationFusion gene name: NAT8L-DBNDD1
Fusion gene ID: 57316
HgeneTgene
Gene symbol

NAT8L

DBNDD1

Gene ID

339983

79007

Gene nameN-acetyltransferase 8 likedysbindin domain containing 1
SynonymsCML3|NACED|NAT8-LIKE-
Cytomap

4p16.3

16q24.3

Type of geneprotein-codingprotein-coding
DescriptionN-acetylaspartate synthetaseN-acetyltransferase 8-like (GCN5-related, putative)NAA synthetaseShaticamello-like protein 3dysbindin domain-containing protein 1dysbindin (dystrobrevin binding protein 1) domain containing 1
Modification date2020031320200318
UniProtAcc

Q8N9F0

Q9H9R9

Ensembl transtripts involved in fusion geneENST00000331662, ENST00000423729, 
ENST00000392973, ENST00000002501, 
ENST00000304733, ENST00000568838, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 1 X 1=1
# samples 41
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: NAT8L [Title/Abstract] AND DBNDD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAT8L(2062889)-DBNDD1(90075838), # samples:4
Anticipated loss of major functional domain due to fusion event.NAT8L-DBNDD1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NAT8L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DBNDD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0157-01ANAT8Lchr4

2062889

-DBNDD1chr16

90075838

-
ChimerDB4GBMTCGA-06-0157-01ANAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
ChimerDB4GBMTCGA-06-0157NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-


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Fusion Gene ORF analysis for NAT8L-DBNDD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000331662ENST00000392973NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
Frame-shiftENST00000423729ENST00000392973NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
In-frameENST00000331662ENST00000002501NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
In-frameENST00000331662ENST00000304733NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
In-frameENST00000331662ENST00000568838NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
In-frameENST00000423729ENST00000002501NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
In-frameENST00000423729ENST00000304733NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-
In-frameENST00000423729ENST00000568838NAT8Lchr4

2062889

+DBNDD1chr16

90075838

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423729NAT8Lchr42062889+ENST00000304733DBNDD1chr1690075838-24575410986328
ENST00000423729NAT8Lchr42062889+ENST00000002501DBNDD1chr1690075838-24575410986328
ENST00000423729NAT8Lchr42062889+ENST00000568838DBNDD1chr1690075838-11335410986328
ENST00000331662NAT8Lchr42062889+ENST00000304733DBNDD1chr1690075838-215724111941907237
ENST00000331662NAT8Lchr42062889+ENST00000002501DBNDD1chr1690075838-215724111941907237
ENST00000331662NAT8Lchr42062889+ENST00000568838DBNDD1chr1690075838-83324130686218

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423729ENST00000304733NAT8Lchr42062889+DBNDD1chr1690075838-0.0153386730.9846614
ENST00000423729ENST00000002501NAT8Lchr42062889+DBNDD1chr1690075838-0.0153386730.9846614
ENST00000423729ENST00000568838NAT8Lchr42062889+DBNDD1chr1690075838-0.0111827130.98881733
ENST00000331662ENST00000304733NAT8Lchr42062889+DBNDD1chr1690075838-0.496912240.50308776
ENST00000331662ENST00000002501NAT8Lchr42062889+DBNDD1chr1690075838-0.496912240.50308776
ENST00000331662ENST00000568838NAT8Lchr42062889+DBNDD1chr1690075838-0.0057582340.99424183

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Fusion Genomic Features for NAT8L-DBNDD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAT8L-DBNDD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:2062889/chr16:90075838)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAT8L

Q8N9F0

DBNDD1

Q9H9R9

FUNCTION: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. {ECO:0000269|PubMed:19524112}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAT8Lchr4:2062889chr16:90075838ENST00000423729+2340_73180303.0Compositional biasNote=Pro-rich
HgeneNAT8Lchr4:2062889chr16:90075838ENST00000423729+23121_141180303.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAT8Lchr4:2062889chr16:90075838ENST00000331662+2340_7312135.0Compositional biasNote=Pro-rich
HgeneNAT8Lchr4:2062889chr16:90075838ENST00000331662+23143_28312135.0DomainN-acetyltransferase
HgeneNAT8Lchr4:2062889chr16:90075838ENST00000423729+23143_283180303.0DomainN-acetyltransferase
HgeneNAT8Lchr4:2062889chr16:90075838ENST00000331662+23121_14112135.0TransmembraneHelical


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Fusion Gene Sequence for NAT8L-DBNDD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57316_57316_1_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000331662_DBNDD1_chr16_90075838_ENST00000002501_length(transcript)=2157nt_BP=241nt
GAGCGCATCCCTAACACGGCCTTCCGCGGCCTGCGGCAGCACCCGCGCGCGCAGCTGCTCTACGCCCTGCTGGCGGCGCTGTGCTTCGCC
GTGAGCCGCTCGCTGCTGCTGACGTGCCTGGTGCCGGCCGCGCTGCTGGGCCTGCGCTACTACTACAGCCGCAAGGTGATCCGCGCCTAC
CTGGAGTGCGCGCTGCACACGGACATGGCGGACATCGAGCAGTACTACATGAAGCCGCCCGAGATCGTTAAGGAGGCTGAGGTGCCGCAG
GCTGCGCTGGGCGTCCCAGCCCAGGGGACAGGGGACAATGGCCACACGCCTGTGGAGGAGGAGGTCGGGGGCATCCCAGTACCAGCACCG
GGGCTCCTGCAGGTCACGGAGAGGAGGCAGCCTCTGAGCAGCGTCTCCTCTCTGGAGGTCCACTTCGACCTCCTGGACCTCACTGAGCTC
ACCGACATGTCGGACCAGGAGCTGGCCGAGGTCTTTGCTGACTCGGACGACGAGAACCTCAACACCGAGTCCCCAGCAGGTCTGCACCCG
CTGCCCCGGGCCGGCTACCTGCGCTCCCCTTCCTGGACGAGGACAAGGGCTGAGCAGAGCCACGAGAAGCAGCCCCTAGGCGACCCCGAG
CGGCAGGCCACAGTCCTGGACACGTTTCTCACTGTGGAGAGGCCCCAGGAGGACTAGACCATCTCCACCTGCCCCAGCTCCTGCAGGGAT
GGGGTCCGAACACGATGGCAGATCTGGGCAGTGCTGACCCAGCAGACACACTTCACCCGCCCACGAGGCTCCAGCCGTCACCTCCTGACA
CACACCCTGGGGGCAGCTCTCTGCCAGCCCCGAGACCGGCCTTGTCTGCTGGGCACGGGTCTTCGCCTCACTTGGAGACCAGCCGGCTTT
CCTGGGGGACACACGGGGCCCCCGGATGCCTCTGGGAGCCCCAGCACAAGCACAGCCCAGTGGCCTTACGTCCAGCTCGTTCCTGGGCCC
CGAGTCAGGAAGACAGCGTCACGGAGTCACTGCCAGGAACGTGCTGAGGAATGGAGTGGCCCACGGCGGCCTTGGGGTGAAGGGGACCCA
GGCCTGTGACAGCCACTCCAGGAACTCCTGGGGGTGCTCCAACCTCCGCGTTTTCCTGTGCTGCCAAGCTCAGAAGCCAGAGGCGGGTTT
GGTAGTGGCTAATGGGACAATGTGCTGTCCAGCAAAGCACACATGGAGAAGCGGCCCCAAAATTCCCACCTTGATTTCCATCCTGCCCCT
TCTTCTACTCCACGGAGGCGCTGTCTCACTAGGGTCCCCTCCCCAAGGCTCAGCTCTAAGACCTGCACCTGCTTCTCTTGGCCCCTGCGT
GACAGACAAGTCCATTCCCTCCTTAGCTCAGAACACCAAATATCACCAGACTGCCTAAGAGACTTGATGACACCTCCCGGAATGCTCTCG
GGGTGGGGTTCACCTCTCCTTGTCCTGCACCCACTGCTAGGCCACATTCTCGTTTCTGCTCACATCCCATTGCCCGGCTACAAGGCCTGC
CCACGGCCCTTAAACTTGCTGGGCAGGTTTGGAGCCCATGGGACCCCGTGGGTCTCTGTCCAGGAGCAGCAGAGGAGGCTGACAGGCCCT
GCTCCCTCTGCTCTGGGGGTGTCTGGGAGCCCCAGCTCACACCCTCCCAATGCTTATATGCTGAAGCTCACAGAATGGGCTTCTTGCCTG
ACAGCAAGTCAAAGAATGAGTTTAATATCAAAGTGTAAGCTTACTTTCCATCCCCAAGCCAGCCTGCCCCCTGCCCCATTTCCCATGAGC
ACACTTCTGGGGAAGGAAAACAGGCTCCTGGCCTTCACTCTCAGCAGAGCTTTGGAGATGCCCCAGGCATGCCCTGAGCTCCTTCTGTGT
ACCTGCTCCCACTTCTGAGCCACCCGCTGCCCCTCCGCACTGCTGGCAAACCCAGTTCCTGCCTCAGCCAGGTCTCCTTCCCTGGTTTCC
AGTCACACAGAGCCCAGCAGCTTTCTCTTTCAGTCCCATAAGGGCAGCCTTGTGTCCCTGGCCACACTTCCACCCGCCAGGGTCTTCCTC

>57316_57316_1_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000331662_DBNDD1_chr16_90075838_ENST00000002501_length(amino acids)=237AA_BP=
MSSKAHMEKRPQNSHLDFHPAPSSTPRRRCLTRVPSPRLSSKTCTCFSWPLRDRQVHSLLSSEHQISPDCLRDLMTPPGMLSGWGSPLLV
LHPLLGHILVSAHIPLPGYKACPRPLNLLGRFGAHGTPWVSVQEQQRRLTGPAPSALGVSGSPSSHPPNAYMLKLTEWASCLTASQRMSL

--------------------------------------------------------------
>57316_57316_2_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000331662_DBNDD1_chr16_90075838_ENST00000304733_length(transcript)=2157nt_BP=241nt
GAGCGCATCCCTAACACGGCCTTCCGCGGCCTGCGGCAGCACCCGCGCGCGCAGCTGCTCTACGCCCTGCTGGCGGCGCTGTGCTTCGCC
GTGAGCCGCTCGCTGCTGCTGACGTGCCTGGTGCCGGCCGCGCTGCTGGGCCTGCGCTACTACTACAGCCGCAAGGTGATCCGCGCCTAC
CTGGAGTGCGCGCTGCACACGGACATGGCGGACATCGAGCAGTACTACATGAAGCCGCCCGAGATCGTTAAGGAGGCTGAGGTGCCGCAG
GCTGCGCTGGGCGTCCCAGCCCAGGGGACAGGGGACAATGGCCACACGCCTGTGGAGGAGGAGGTCGGGGGCATCCCAGTACCAGCACCG
GGGCTCCTGCAGGTCACGGAGAGGAGGCAGCCTCTGAGCAGCGTCTCCTCTCTGGAGGTCCACTTCGACCTCCTGGACCTCACTGAGCTC
ACCGACATGTCGGACCAGGAGCTGGCCGAGGTCTTTGCTGACTCGGACGACGAGAACCTCAACACCGAGTCCCCAGCAGGTCTGCACCCG
CTGCCCCGGGCCGGCTACCTGCGCTCCCCTTCCTGGACGAGGACAAGGGCTGAGCAGAGCCACGAGAAGCAGCCCCTAGGCGACCCCGAG
CGGCAGGCCACAGTCCTGGACACGTTTCTCACTGTGGAGAGGCCCCAGGAGGACTAGACCATCTCCACCTGCCCCAGCTCCTGCAGGGAT
GGGGTCCGAACACGATGGCAGATCTGGGCAGTGCTGACCCAGCAGACACACTTCACCCGCCCACGAGGCTCCAGCCGTCACCTCCTGACA
CACACCCTGGGGGCAGCTCTCTGCCAGCCCCGAGACCGGCCTTGTCTGCTGGGCACGGGTCTTCGCCTCACTTGGAGACCAGCCGGCTTT
CCTGGGGGACACACGGGGCCCCCGGATGCCTCTGGGAGCCCCAGCACAAGCACAGCCCAGTGGCCTTACGTCCAGCTCGTTCCTGGGCCC
CGAGTCAGGAAGACAGCGTCACGGAGTCACTGCCAGGAACGTGCTGAGGAATGGAGTGGCCCACGGCGGCCTTGGGGTGAAGGGGACCCA
GGCCTGTGACAGCCACTCCAGGAACTCCTGGGGGTGCTCCAACCTCCGCGTTTTCCTGTGCTGCCAAGCTCAGAAGCCAGAGGCGGGTTT
GGTAGTGGCTAATGGGACAATGTGCTGTCCAGCAAAGCACACATGGAGAAGCGGCCCCAAAATTCCCACCTTGATTTCCATCCTGCCCCT
TCTTCTACTCCACGGAGGCGCTGTCTCACTAGGGTCCCCTCCCCAAGGCTCAGCTCTAAGACCTGCACCTGCTTCTCTTGGCCCCTGCGT
GACAGACAAGTCCATTCCCTCCTTAGCTCAGAACACCAAATATCACCAGACTGCCTAAGAGACTTGATGACACCTCCCGGAATGCTCTCG
GGGTGGGGTTCACCTCTCCTTGTCCTGCACCCACTGCTAGGCCACATTCTCGTTTCTGCTCACATCCCATTGCCCGGCTACAAGGCCTGC
CCACGGCCCTTAAACTTGCTGGGCAGGTTTGGAGCCCATGGGACCCCGTGGGTCTCTGTCCAGGAGCAGCAGAGGAGGCTGACAGGCCCT
GCTCCCTCTGCTCTGGGGGTGTCTGGGAGCCCCAGCTCACACCCTCCCAATGCTTATATGCTGAAGCTCACAGAATGGGCTTCTTGCCTG
ACAGCAAGTCAAAGAATGAGTTTAATATCAAAGTGTAAGCTTACTTTCCATCCCCAAGCCAGCCTGCCCCCTGCCCCATTTCCCATGAGC
ACACTTCTGGGGAAGGAAAACAGGCTCCTGGCCTTCACTCTCAGCAGAGCTTTGGAGATGCCCCAGGCATGCCCTGAGCTCCTTCTGTGT
ACCTGCTCCCACTTCTGAGCCACCCGCTGCCCCTCCGCACTGCTGGCAAACCCAGTTCCTGCCTCAGCCAGGTCTCCTTCCCTGGTTTCC
AGTCACACAGAGCCCAGCAGCTTTCTCTTTCAGTCCCATAAGGGCAGCCTTGTGTCCCTGGCCACACTTCCACCCGCCAGGGTCTTCCTC

>57316_57316_2_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000331662_DBNDD1_chr16_90075838_ENST00000304733_length(amino acids)=237AA_BP=
MSSKAHMEKRPQNSHLDFHPAPSSTPRRRCLTRVPSPRLSSKTCTCFSWPLRDRQVHSLLSSEHQISPDCLRDLMTPPGMLSGWGSPLLV
LHPLLGHILVSAHIPLPGYKACPRPLNLLGRFGAHGTPWVSVQEQQRRLTGPAPSALGVSGSPSSHPPNAYMLKLTEWASCLTASQRMSL

--------------------------------------------------------------
>57316_57316_3_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000331662_DBNDD1_chr16_90075838_ENST00000568838_length(transcript)=833nt_BP=241nt
GAGCGCATCCCTAACACGGCCTTCCGCGGCCTGCGGCAGCACCCGCGCGCGCAGCTGCTCTACGCCCTGCTGGCGGCGCTGTGCTTCGCC
GTGAGCCGCTCGCTGCTGCTGACGTGCCTGGTGCCGGCCGCGCTGCTGGGCCTGCGCTACTACTACAGCCGCAAGGTGATCCGCGCCTAC
CTGGAGTGCGCGCTGCACACGGACATGGCGGACATCGAGCAGTACTACATGAAGCCGCCCGAGATCGTTAAGGAGGCTGAGGTGCCGCAG
GCTGCGCTGGGCGTCCCAGCCCAGGGGACAGGGGACAATGGCCACACGCCTGTGGAGGAGGAGGTCGGGGGCATCCCAGTACCAGCACCG
GGGCTCCTGCAGGTCACGGAGAGGAGGCAGCCTCTGAGCAGCGTCTCCTCTCTGGAGGTCCACTTCGACCTCCTGGACCTCACTGAGCTC
ACCGACATGTCGGACCAGGAGCTGGCCGAGGTCTTTGCTGACTCGGACGACGAGAACCTCAACACCGAGTCCCCAGCAGGTCTGCACCCG
CTGCCCCGGGCCGGCTACCTGCGCTCCCCTTCCTGGACGAGGACAAGGGCTGAGCAGAGCCACGAGAAGCAGCCCCTAGGCGACCCCGAG
CGGCAGGCCACAGTCCTGGACACGTTTCTCACTGTGGAGAGGCCCCAGGAGGACTAGACCATCTCCACCTGCCCCAGCTCCTGCAGGGAT
GGGGTCCGAACACGATGGCAGATCTGGGCAGTGCTGACCCAGCAGACACACTTCACCCGCCCACGAGGCTCCAGCCGTCACCTCCTGACA

>57316_57316_3_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000331662_DBNDD1_chr16_90075838_ENST00000568838_length(amino acids)=218AA_BP=70
MRQHPRAQLLYALLAALCFAVSRSLLLTCLVPAALLGLRYYYSRKVIRAYLECALHTDMADIEQYYMKPPEIVKEAEVPQAALGVPAQGT
GDNGHTPVEEEVGGIPVPAPGLLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENLNTESPAGLHPLPRAGYLRSP

--------------------------------------------------------------
>57316_57316_4_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000423729_DBNDD1_chr16_90075838_ENST00000002501_length(transcript)=2457nt_BP=541nt
ATGCATTGTGGGCCTCCCGACATGGTCTGCGAGACGAAGATCGTGGCCGCCGAGGACCATGAGGCGCTGCCGGGGGCCAAGAAGGACGCG
CTGCTCGCCGCCGCCGGCGCCATGTGGCCCCCGCTGCCCGCCGCGCCCGGGCCGGCCGCCGCGCCCCCCGCGCCCCCACCTGCCCCGGTG
GCTCAGCCTCACGGCGGGGCGGGGGGCGCGGGGCCGCCGGGGGGGCGCGGCGTGTGCATCCGCGAGTTCCGTGCGGCCGAGCAGGAGGCG
GCGCGCCGCATCTTCTACGACGGCATCATGGAGCGCATCCCTAACACGGCCTTCCGCGGCCTGCGGCAGCACCCGCGCGCGCAGCTGCTC
TACGCCCTGCTGGCGGCGCTGTGCTTCGCCGTGAGCCGCTCGCTGCTGCTGACGTGCCTGGTGCCGGCCGCGCTGCTGGGCCTGCGCTAC
TACTACAGCCGCAAGGTGATCCGCGCCTACCTGGAGTGCGCGCTGCACACGGACATGGCGGACATCGAGCAGTACTACATGAAGCCGCCC
GAGATCGTTAAGGAGGCTGAGGTGCCGCAGGCTGCGCTGGGCGTCCCAGCCCAGGGGACAGGGGACAATGGCCACACGCCTGTGGAGGAG
GAGGTCGGGGGCATCCCAGTACCAGCACCGGGGCTCCTGCAGGTCACGGAGAGGAGGCAGCCTCTGAGCAGCGTCTCCTCTCTGGAGGTC
CACTTCGACCTCCTGGACCTCACTGAGCTCACCGACATGTCGGACCAGGAGCTGGCCGAGGTCTTTGCTGACTCGGACGACGAGAACCTC
AACACCGAGTCCCCAGCAGGTCTGCACCCGCTGCCCCGGGCCGGCTACCTGCGCTCCCCTTCCTGGACGAGGACAAGGGCTGAGCAGAGC
CACGAGAAGCAGCCCCTAGGCGACCCCGAGCGGCAGGCCACAGTCCTGGACACGTTTCTCACTGTGGAGAGGCCCCAGGAGGACTAGACC
ATCTCCACCTGCCCCAGCTCCTGCAGGGATGGGGTCCGAACACGATGGCAGATCTGGGCAGTGCTGACCCAGCAGACACACTTCACCCGC
CCACGAGGCTCCAGCCGTCACCTCCTGACACACACCCTGGGGGCAGCTCTCTGCCAGCCCCGAGACCGGCCTTGTCTGCTGGGCACGGGT
CTTCGCCTCACTTGGAGACCAGCCGGCTTTCCTGGGGGACACACGGGGCCCCCGGATGCCTCTGGGAGCCCCAGCACAAGCACAGCCCAG
TGGCCTTACGTCCAGCTCGTTCCTGGGCCCCGAGTCAGGAAGACAGCGTCACGGAGTCACTGCCAGGAACGTGCTGAGGAATGGAGTGGC
CCACGGCGGCCTTGGGGTGAAGGGGACCCAGGCCTGTGACAGCCACTCCAGGAACTCCTGGGGGTGCTCCAACCTCCGCGTTTTCCTGTG
CTGCCAAGCTCAGAAGCCAGAGGCGGGTTTGGTAGTGGCTAATGGGACAATGTGCTGTCCAGCAAAGCACACATGGAGAAGCGGCCCCAA
AATTCCCACCTTGATTTCCATCCTGCCCCTTCTTCTACTCCACGGAGGCGCTGTCTCACTAGGGTCCCCTCCCCAAGGCTCAGCTCTAAG
ACCTGCACCTGCTTCTCTTGGCCCCTGCGTGACAGACAAGTCCATTCCCTCCTTAGCTCAGAACACCAAATATCACCAGACTGCCTAAGA
GACTTGATGACACCTCCCGGAATGCTCTCGGGGTGGGGTTCACCTCTCCTTGTCCTGCACCCACTGCTAGGCCACATTCTCGTTTCTGCT
CACATCCCATTGCCCGGCTACAAGGCCTGCCCACGGCCCTTAAACTTGCTGGGCAGGTTTGGAGCCCATGGGACCCCGTGGGTCTCTGTC
CAGGAGCAGCAGAGGAGGCTGACAGGCCCTGCTCCCTCTGCTCTGGGGGTGTCTGGGAGCCCCAGCTCACACCCTCCCAATGCTTATATG
CTGAAGCTCACAGAATGGGCTTCTTGCCTGACAGCAAGTCAAAGAATGAGTTTAATATCAAAGTGTAAGCTTACTTTCCATCCCCAAGCC
AGCCTGCCCCCTGCCCCATTTCCCATGAGCACACTTCTGGGGAAGGAAAACAGGCTCCTGGCCTTCACTCTCAGCAGAGCTTTGGAGATG
CCCCAGGCATGCCCTGAGCTCCTTCTGTGTACCTGCTCCCACTTCTGAGCCACCCGCTGCCCCTCCGCACTGCTGGCAAACCCAGTTCCT
GCCTCAGCCAGGTCTCCTTCCCTGGTTTCCAGTCACACAGAGCCCAGCAGCTTTCTCTTTCAGTCCCATAAGGGCAGCCTTGTGTCCCTG
GCCACACTTCCACCCGCCAGGGTCTTCCTCCCCATCTTTCCATCCTTCCTGCTGAGCTTCCACAGAGCTCGTTTGCAAACAGGGGGATTA

>57316_57316_4_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000423729_DBNDD1_chr16_90075838_ENST00000002501_length(amino acids)=328AA_BP=180
MHCGPPDMVCETKIVAAEDHEALPGAKKDALLAAAGAMWPPLPAAPGPAAAPPAPPPAPVAQPHGGAGGAGPPGGRGVCIREFRAAEQEA
ARRIFYDGIMERIPNTAFRGLRQHPRAQLLYALLAALCFAVSRSLLLTCLVPAALLGLRYYYSRKVIRAYLECALHTDMADIEQYYMKPP
EIVKEAEVPQAALGVPAQGTGDNGHTPVEEEVGGIPVPAPGLLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENL

--------------------------------------------------------------
>57316_57316_5_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000423729_DBNDD1_chr16_90075838_ENST00000304733_length(transcript)=2457nt_BP=541nt
ATGCATTGTGGGCCTCCCGACATGGTCTGCGAGACGAAGATCGTGGCCGCCGAGGACCATGAGGCGCTGCCGGGGGCCAAGAAGGACGCG
CTGCTCGCCGCCGCCGGCGCCATGTGGCCCCCGCTGCCCGCCGCGCCCGGGCCGGCCGCCGCGCCCCCCGCGCCCCCACCTGCCCCGGTG
GCTCAGCCTCACGGCGGGGCGGGGGGCGCGGGGCCGCCGGGGGGGCGCGGCGTGTGCATCCGCGAGTTCCGTGCGGCCGAGCAGGAGGCG
GCGCGCCGCATCTTCTACGACGGCATCATGGAGCGCATCCCTAACACGGCCTTCCGCGGCCTGCGGCAGCACCCGCGCGCGCAGCTGCTC
TACGCCCTGCTGGCGGCGCTGTGCTTCGCCGTGAGCCGCTCGCTGCTGCTGACGTGCCTGGTGCCGGCCGCGCTGCTGGGCCTGCGCTAC
TACTACAGCCGCAAGGTGATCCGCGCCTACCTGGAGTGCGCGCTGCACACGGACATGGCGGACATCGAGCAGTACTACATGAAGCCGCCC
GAGATCGTTAAGGAGGCTGAGGTGCCGCAGGCTGCGCTGGGCGTCCCAGCCCAGGGGACAGGGGACAATGGCCACACGCCTGTGGAGGAG
GAGGTCGGGGGCATCCCAGTACCAGCACCGGGGCTCCTGCAGGTCACGGAGAGGAGGCAGCCTCTGAGCAGCGTCTCCTCTCTGGAGGTC
CACTTCGACCTCCTGGACCTCACTGAGCTCACCGACATGTCGGACCAGGAGCTGGCCGAGGTCTTTGCTGACTCGGACGACGAGAACCTC
AACACCGAGTCCCCAGCAGGTCTGCACCCGCTGCCCCGGGCCGGCTACCTGCGCTCCCCTTCCTGGACGAGGACAAGGGCTGAGCAGAGC
CACGAGAAGCAGCCCCTAGGCGACCCCGAGCGGCAGGCCACAGTCCTGGACACGTTTCTCACTGTGGAGAGGCCCCAGGAGGACTAGACC
ATCTCCACCTGCCCCAGCTCCTGCAGGGATGGGGTCCGAACACGATGGCAGATCTGGGCAGTGCTGACCCAGCAGACACACTTCACCCGC
CCACGAGGCTCCAGCCGTCACCTCCTGACACACACCCTGGGGGCAGCTCTCTGCCAGCCCCGAGACCGGCCTTGTCTGCTGGGCACGGGT
CTTCGCCTCACTTGGAGACCAGCCGGCTTTCCTGGGGGACACACGGGGCCCCCGGATGCCTCTGGGAGCCCCAGCACAAGCACAGCCCAG
TGGCCTTACGTCCAGCTCGTTCCTGGGCCCCGAGTCAGGAAGACAGCGTCACGGAGTCACTGCCAGGAACGTGCTGAGGAATGGAGTGGC
CCACGGCGGCCTTGGGGTGAAGGGGACCCAGGCCTGTGACAGCCACTCCAGGAACTCCTGGGGGTGCTCCAACCTCCGCGTTTTCCTGTG
CTGCCAAGCTCAGAAGCCAGAGGCGGGTTTGGTAGTGGCTAATGGGACAATGTGCTGTCCAGCAAAGCACACATGGAGAAGCGGCCCCAA
AATTCCCACCTTGATTTCCATCCTGCCCCTTCTTCTACTCCACGGAGGCGCTGTCTCACTAGGGTCCCCTCCCCAAGGCTCAGCTCTAAG
ACCTGCACCTGCTTCTCTTGGCCCCTGCGTGACAGACAAGTCCATTCCCTCCTTAGCTCAGAACACCAAATATCACCAGACTGCCTAAGA
GACTTGATGACACCTCCCGGAATGCTCTCGGGGTGGGGTTCACCTCTCCTTGTCCTGCACCCACTGCTAGGCCACATTCTCGTTTCTGCT
CACATCCCATTGCCCGGCTACAAGGCCTGCCCACGGCCCTTAAACTTGCTGGGCAGGTTTGGAGCCCATGGGACCCCGTGGGTCTCTGTC
CAGGAGCAGCAGAGGAGGCTGACAGGCCCTGCTCCCTCTGCTCTGGGGGTGTCTGGGAGCCCCAGCTCACACCCTCCCAATGCTTATATG
CTGAAGCTCACAGAATGGGCTTCTTGCCTGACAGCAAGTCAAAGAATGAGTTTAATATCAAAGTGTAAGCTTACTTTCCATCCCCAAGCC
AGCCTGCCCCCTGCCCCATTTCCCATGAGCACACTTCTGGGGAAGGAAAACAGGCTCCTGGCCTTCACTCTCAGCAGAGCTTTGGAGATG
CCCCAGGCATGCCCTGAGCTCCTTCTGTGTACCTGCTCCCACTTCTGAGCCACCCGCTGCCCCTCCGCACTGCTGGCAAACCCAGTTCCT
GCCTCAGCCAGGTCTCCTTCCCTGGTTTCCAGTCACACAGAGCCCAGCAGCTTTCTCTTTCAGTCCCATAAGGGCAGCCTTGTGTCCCTG
GCCACACTTCCACCCGCCAGGGTCTTCCTCCCCATCTTTCCATCCTTCCTGCTGAGCTTCCACAGAGCTCGTTTGCAAACAGGGGGATTA

>57316_57316_5_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000423729_DBNDD1_chr16_90075838_ENST00000304733_length(amino acids)=328AA_BP=180
MHCGPPDMVCETKIVAAEDHEALPGAKKDALLAAAGAMWPPLPAAPGPAAAPPAPPPAPVAQPHGGAGGAGPPGGRGVCIREFRAAEQEA
ARRIFYDGIMERIPNTAFRGLRQHPRAQLLYALLAALCFAVSRSLLLTCLVPAALLGLRYYYSRKVIRAYLECALHTDMADIEQYYMKPP
EIVKEAEVPQAALGVPAQGTGDNGHTPVEEEVGGIPVPAPGLLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENL

--------------------------------------------------------------
>57316_57316_6_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000423729_DBNDD1_chr16_90075838_ENST00000568838_length(transcript)=1133nt_BP=541nt
ATGCATTGTGGGCCTCCCGACATGGTCTGCGAGACGAAGATCGTGGCCGCCGAGGACCATGAGGCGCTGCCGGGGGCCAAGAAGGACGCG
CTGCTCGCCGCCGCCGGCGCCATGTGGCCCCCGCTGCCCGCCGCGCCCGGGCCGGCCGCCGCGCCCCCCGCGCCCCCACCTGCCCCGGTG
GCTCAGCCTCACGGCGGGGCGGGGGGCGCGGGGCCGCCGGGGGGGCGCGGCGTGTGCATCCGCGAGTTCCGTGCGGCCGAGCAGGAGGCG
GCGCGCCGCATCTTCTACGACGGCATCATGGAGCGCATCCCTAACACGGCCTTCCGCGGCCTGCGGCAGCACCCGCGCGCGCAGCTGCTC
TACGCCCTGCTGGCGGCGCTGTGCTTCGCCGTGAGCCGCTCGCTGCTGCTGACGTGCCTGGTGCCGGCCGCGCTGCTGGGCCTGCGCTAC
TACTACAGCCGCAAGGTGATCCGCGCCTACCTGGAGTGCGCGCTGCACACGGACATGGCGGACATCGAGCAGTACTACATGAAGCCGCCC
GAGATCGTTAAGGAGGCTGAGGTGCCGCAGGCTGCGCTGGGCGTCCCAGCCCAGGGGACAGGGGACAATGGCCACACGCCTGTGGAGGAG
GAGGTCGGGGGCATCCCAGTACCAGCACCGGGGCTCCTGCAGGTCACGGAGAGGAGGCAGCCTCTGAGCAGCGTCTCCTCTCTGGAGGTC
CACTTCGACCTCCTGGACCTCACTGAGCTCACCGACATGTCGGACCAGGAGCTGGCCGAGGTCTTTGCTGACTCGGACGACGAGAACCTC
AACACCGAGTCCCCAGCAGGTCTGCACCCGCTGCCCCGGGCCGGCTACCTGCGCTCCCCTTCCTGGACGAGGACAAGGGCTGAGCAGAGC
CACGAGAAGCAGCCCCTAGGCGACCCCGAGCGGCAGGCCACAGTCCTGGACACGTTTCTCACTGTGGAGAGGCCCCAGGAGGACTAGACC
ATCTCCACCTGCCCCAGCTCCTGCAGGGATGGGGTCCGAACACGATGGCAGATCTGGGCAGTGCTGACCCAGCAGACACACTTCACCCGC

>57316_57316_6_NAT8L-DBNDD1_NAT8L_chr4_2062889_ENST00000423729_DBNDD1_chr16_90075838_ENST00000568838_length(amino acids)=328AA_BP=180
MHCGPPDMVCETKIVAAEDHEALPGAKKDALLAAAGAMWPPLPAAPGPAAAPPAPPPAPVAQPHGGAGGAGPPGGRGVCIREFRAAEQEA
ARRIFYDGIMERIPNTAFRGLRQHPRAQLLYALLAALCFAVSRSLLLTCLVPAALLGLRYYYSRKVIRAYLECALHTDMADIEQYYMKPP
EIVKEAEVPQAALGVPAQGTGDNGHTPVEEEVGGIPVPAPGLLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NAT8L-DBNDD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAT8L-DBNDD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAT8L-DBNDD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource