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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NBAS-RASGRP3 (FusionGDB2 ID:57385)

Fusion Gene Summary for NBAS-RASGRP3

check button Fusion gene summary
Fusion gene informationFusion gene name: NBAS-RASGRP3
Fusion gene ID: 57385
HgeneTgene
Gene symbol

NBAS

RASGRP3

Gene ID

51594

25780

Gene nameNBAS subunit of NRZ tethering complexRAS guanyl releasing protein 3
SynonymsILFS2|NAG|SOPHGRP3
Cytomap

2p24.3

2p22.3

Type of geneprotein-codingprotein-coding
Descriptionneuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma amplified sequenceneuroblastoma-amplified gene proteinras guanyl-releasing protein 3CalDAG-GEFIIIRAS guanyl releasing protein 3 (calcium and DAG-regulated)calcium and DAG-regulated guanine nucleotide exchange factor IIIcalcium- and diacylglycerol-regulated guanine nucleotide exchange factor IIIguanine n
Modification date2020031320200313
UniProtAcc

A2RRP1

.
Ensembl transtripts involved in fusion geneENST00000281513, ENST00000441750, 
ENST00000482731, ENST00000403687, 
ENST00000407811, ENST00000402538, 
Fusion gene scores* DoF score18 X 15 X 9=24303 X 4 X 3=36
# samples 184
** MAII scorelog2(18/2430*10)=-3.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NBAS [Title/Abstract] AND RASGRP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNBAS(15415608)-RASGRP3(33787796), # samples:1
Anticipated loss of major functional domain due to fusion event.NBAS-RASGRP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NBAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RASGRP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AX-A3G3-01ANBASchr2

15415608

-RASGRP3chr2

33787796

+


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Fusion Gene ORF analysis for NBAS-RASGRP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000281513ENST00000482731NBASchr2

15415608

-RASGRP3chr2

33787796

+
5CDS-intronENST00000441750ENST00000482731NBASchr2

15415608

-RASGRP3chr2

33787796

+
Frame-shiftENST00000281513ENST00000403687NBASchr2

15415608

-RASGRP3chr2

33787796

+
Frame-shiftENST00000281513ENST00000407811NBASchr2

15415608

-RASGRP3chr2

33787796

+
Frame-shiftENST00000441750ENST00000403687NBASchr2

15415608

-RASGRP3chr2

33787796

+
Frame-shiftENST00000441750ENST00000407811NBASchr2

15415608

-RASGRP3chr2

33787796

+
In-frameENST00000281513ENST00000402538NBASchr2

15415608

-RASGRP3chr2

33787796

+
In-frameENST00000441750ENST00000402538NBASchr2

15415608

-RASGRP3chr2

33787796

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441750NBASchr215415608-ENST00000402538RASGRP3chr233787796+74125390553981797
ENST00000281513NBASchr215415608-ENST00000402538RASGRP3chr233787796+77725750557581917

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441750ENST00000402538NBASchr215415608-RASGRP3chr233787796+0.0002938450.9997061
ENST00000281513ENST00000402538NBASchr215415608-RASGRP3chr233787796+0.0001373190.9998627

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Fusion Genomic Features for NBAS-RASGRP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NBASchr215415607-RASGRP3chr233787795+0.0032686560.9967314
NBASchr215415607-RASGRP3chr233787795+0.0032686560.9967314

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NBAS-RASGRP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:15415608/chr2:33787796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBAS

A2RRP1

.
FUNCTION: Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). {ECO:0000269|PubMed:19369418, ECO:0000305}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNBASchr2:15415608chr2:33787796ENST00000281513-44521421_142519082372.0Compositional biasNote=Poly-Thr
HgeneNBASchr2:15415608chr2:33787796ENST00000441750-42501421_142517882252.0Compositional biasNote=Poly-Thr
HgeneNBASchr2:15415608chr2:33787796ENST00000281513-4452130_16919082372.0RepeatNote=WD 1
HgeneNBASchr2:15415608chr2:33787796ENST00000281513-4452316_35519082372.0RepeatNote=WD 2
HgeneNBASchr2:15415608chr2:33787796ENST00000441750-4250130_16917882252.0RepeatNote=WD 1
HgeneNBASchr2:15415608chr2:33787796ENST00000441750-4250316_35517882252.0RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNBASchr2:15415608chr2:33787796ENST00000281513-44522242_224719082372.0Compositional biasNote=Poly-Leu
HgeneNBASchr2:15415608chr2:33787796ENST00000441750-42502242_224717882252.0Compositional biasNote=Poly-Leu
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004025381719433_444688691.0Calcium binding1
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004025381719462_473688691.0Calcium binding2
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004036871618433_444688691.0Calcium binding1
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004036871618462_473688691.0Calcium binding2
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004078111517433_444687690.0Calcium binding1
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004078111517462_473687690.0Calcium binding2
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004025381719152_383688691.0DomainRas-GEF
TgeneRASGRP3chr2:15415608chr2:33787796ENST0000040253817193_125688691.0DomainN-terminal Ras-GEF
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004025381719420_455688691.0DomainEF-hand 1
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004025381719449_484688691.0DomainEF-hand 2
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004036871618152_383688691.0DomainRas-GEF
TgeneRASGRP3chr2:15415608chr2:33787796ENST0000040368716183_125688691.0DomainN-terminal Ras-GEF
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004036871618420_455688691.0DomainEF-hand 1
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004036871618449_484688691.0DomainEF-hand 2
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004078111517152_383687690.0DomainRas-GEF
TgeneRASGRP3chr2:15415608chr2:33787796ENST0000040781115173_125687690.0DomainN-terminal Ras-GEF
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004078111517420_455687690.0DomainEF-hand 1
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004078111517449_484687690.0DomainEF-hand 2
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004025381719494_544688691.0Zinc fingerPhorbol-ester/DAG-type
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004036871618494_544688691.0Zinc fingerPhorbol-ester/DAG-type
TgeneRASGRP3chr2:15415608chr2:33787796ENST000004078111517494_544687690.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for NBAS-RASGRP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57385_57385_1_NBAS-RASGRP3_NBAS_chr2_15415608_ENST00000281513_RASGRP3_chr2_33787796_ENST00000402538_length(transcript)=7772nt_BP=5750nt
CTCCGCTGCCTGAGTCCTCGGCGAACATGGCGGCCCCCGAGTCAGGGCCGGCTTTGAGTCCAGGCACTGCAGAGGGTGAGGAGGAGACGA
TTCTCTATGACTTGTTGGTCAACACCGAGTGGCCACCGGAGACTGAAGTACAGCCTAGAGGCAACCAAAAACATGGTGCATCCTTTATCA
TCACGAAAGCAATTCGAGATCGTTTATTATTTTTACGCCAATACATCTGGTACAGCCCGGCACCTTTTTTGCTCCCTGATGGACTGGTTC
GCTTGGTTAATAAACAGATAAACTGGCATTTGGTACTTGCAAGCAATGGAAAGCTTTTGGCTGCTGTTCAAGATCAGTGTGTGGAAATCA
GGTCTGCAAAAGATGATTTTACATCCATTATTGGGAAATGTCAAGTTCCGAAAGACCCGAAACCCCAGTGGAGACGGGTAGCATGGAGTT
ACGATTGTACCCTACTGGCCTATGCCGAAAGCACAGGAACTGTGAGGGTGTTTGATCTCATGGGAAGTGAACTCTTTGTCATTTCCCCGG
CATCTAGTTTTATAGGTGACTTAAGCTATGCCATTGCTGGGTTGATATTTTTAGAATATAAAGCAAGTGCACAGTGGTCTGCAGAACTCC
TGGTCATCAATTACCGAGGAGAACTTAGAAGTTACCTTGTAAGTGTTGGAACAAATCAGAGCTACCAAGAAAGTCACTGTTTCAGCTTCA
GTAGTCATTATCCTCATGGAATCAACACAGCTATTTACCACCCTGGTCACAGACTTTTACTTGTTGGTGGATGTGAAACTGCTGAAGTAG
GCATGTCAAAAGCTTCTAGCTGTGGCCTTTCTGCCTGGAGAGTTCTTTCAGGATCACCGTATTATAAGCAGGTTACTAATGGTGGAGACG
GGGTTACTGCAGTACCGAAGACACTGGGATTATTAAGGATGTTAAGTGTCAAGTTTTACAGTCGCCAGGGACAAGAACAGGATGGAATTT
TTAAGATGAGCCTTTCTCCAGATGGGATGCTCCTGGCAGCCATTCACTTCTCAGGGAAACTGAGCATCTGGGCGATTCCATCTCTGAAGC
AACAAGGGGAATGGGGTCAAAATGAGCAGCCAGGCTATGATGACCTTAATCCTGATTGGAGGCTCTCTACTGAGAAGAGAAAAAAAATCA
AAGATAAAGAGTCCTTTTACCCACTGATAGATGTCAATTGGTGGGCAGACAGTGCAGTGACTTTAGCTCGATGCTCTGGTGCTTTAACTG
TTTCATCTGTGAAAACTTTGAAGAATTTACTGGGAAAATCCTGTGAATGGTTTGAACCATCACCTCAAGTCACTGCTACCCATGATGGGG
GATTTTTAAGTTTGGAGTGTGAGATTAAACTTGCCCCCAAACGATCTCGTTTGGAGACTAGAGCTGGAGAAGAAGATGAAGGAGAAGAGG
ATTCTGATTCTGATTATGAAATATCTGCCAAGGCTCGCTACTTTGGTTATATAAAACAGGGCCTTTACTTGGTGACTGAAATGGAGCGAT
TTGCACCACCACGGAAACGCCCACGAACCATTACTAAAAACTACCGCCTTGTGAGTTTGCGCTCCACGACACCAGAGGAACTTTATCAGA
GGAAGATTGAAAGTGAAGAGTATGAGGAAGCCTTGTCCTTGGCTCATACCTACGGCCTGGATACTGACCTTGTATATCAGAGGCAGTGGA
GGAAGTCAGCGGTCAACGTTGCTTCAATTCAGAATTATTTGAGTAAAATAAAGAAGCGATCCTGGGTTCTCCATGAGTGTTTGGAAAGAG
TTCCTGAAAATGTGGATGCTGCAAAAGAACTGCTTCAGTATGGATTAAAAGGCACAGACCTGGAGGCTCTTTTAGCAATAGGGAAAGGAG
CAGATGATGGCAGATTTACATTACCTGGTGAAATAGACATTGACAGTATCTCCTATGAAGAGCTTTCACCACCTGATGAAGAGCCTGCCA
AGAATAAAAAGGAAAAGGAGCTCAAGAAGAGACAAGAACTACTGAAATTAGTGAACTTTTCCAAGTTGACACTGGAACAAAAGGAACTTT
GCCGTTGTAGACGGAAGTTATTAACCTACTTAGATCGACTTGCAACATATGAGGAAATCCTAGGAGTGCCTCATGCATCTGAACAGAGAT
ATGATGCTGAATTCTTTAAGAAATTCAGAAATCAGAATATTGTTCTCTCAGCAAGAACTTATGCTCAGGAAAGTAATGTACAAGCCCTGG
AAATTCTGTTTACTTACCATGGTTCCGACCTGCTTCCTCATCGCCTTGCAATTCTGTCCAACTTTCCAGAGACCACTTCTCCACATGAAT
ATTCTGTTTTGCTGCCCGAAGCTTGTTTTAACGGTGACTCCCTGATGATCATTCCTTGGCATGAACATAAACACCGAGCTAAAGATTGGT
GCGAGGAGTTGGCTTGCAGAATGGTTGTTGAGCCGAATCTCCAAGATGAAAGTGAATTCTTGTATGCTGCACAGCCTGAGTTACTAAGGT
TCAGGATGACCCAGCTTACGGTGGAGAAGGTTATGGACTGGTATCAGACCAGAGCAGAGGAAATAGAGCATTATGCTCGGCAGGTGGACT
GTGCATTGTCACTTATTCGACTTGGGATGGAGCGGAATATTCCTGGTTTGCTGGTTCTCTGTGACAATTTGGTTACTCTGGAAACATTGG
TTTATGAAGCCAGGTGTGATGTAACTCTAACCCTGAAAGAACTCCAGCAGATGAAAGACATTGAAAAACTAAGATTACTGATGAATAGTT
GTTCTGAGGATAAATATGTGACAAGTGCCTACCAGTGGATGGTTCCCTTTCTTCATCGTTGTGAGAAACAGTCGCCTGGTGTGGCTAATG
AGCTATTAAAAGAATATTTAGTAACTTTAGCTAAAGGGGACTTAAAATTTCCCCTGAAGATATTTCAGCATTCCAAACCAGATCTGCAGC
AAAAAATTATTCCTGATCAGGACCAACTGATGGCAATAGCACTAGAGTGCATCTATACCTGTGAACGAAATGATCAACTCTGTCTTTGCT
ATGACCTACTAGAATGTCTGCCAGAAAGAGGATATGGTGATAAGACAGAGGCAACCACAAAGCTTCATGACATGGTAGACCAACTGGAAC
AAATTCTCAGTGTGTCAGAGCTTTTGGAAAAACATGGACTCGAGAAACCAATTTCATTTGTTAAAAACACTCAATCTAGCTCAGAAGAGG
CACGCAAGCTGATGGTTAGATTGACGAGGCACACTGGCCGGAAGCAGCCTCCTGTCAGTGAGTCTCATTGGAGAACGTTGCTGCAAGACA
TGTTAACTATGCAGCAGAATGTATACACATGTCTAGATTCTGATGCCTGCTATGAGATATTTACAGAAAGCCTTCTGTGCTCTAGTCGCC
TTGAAAACATCCACCTGGCTGGACAGATGATGCACTGCAGTGCTTGTTCAGAAAATCCTCCAGCTGGTATAGCCCATAAAGGGAAACCCC
ACTACAGGGTCAGCTACGAAAAGAGTATTGACTTGGTTTTGGCTGCCAGCAGAGAGTACTTCAATTCTTCTACCAACCTCACTGATAGCT
GCATGGATCTAGCCAGGTGCTGCTTACAACTGATAACAGACAGACCCCCTGCCATTCAAGAGGAGCTAGATCTTATCCAAGCCGTTGGAT
GTCTTGAAGAATTTGGGGTAAAGATCCTGCCTTTGCAAGTGCGATTGTGCCCTGATCGGATCAGTCTCATCAAGGAGTGTATTTCCCAGT
CCCCCACATGCTATAAACAATCCACCAAGCTTCTGGGCCTTGCTGAGCTGCTGAGGGTTGCAGGTGAGAACCCAGAAGAAAGGCGGGGAC
AGGTTCTAATCCTTTTAGTGGAGCAGGCACTTCGCTTCCATGACTACAAAGCAGCCAGTATGCATTGTCAGGAGCTGATGGCCACAGGTT
ATCCTAAAAGTTGGGATGTTTGTAGCCAGTTAGGACAATCAGAAGGTTACCAGGACTTGGCCACTCGTCAAGAGCTCATGGCTTTTGCTT
TGACACATTGCCCTCCTAGCAGCATTGAACTTCTTTTGGCAGCTAGCAGCTCTCTGCAGACAGAAATTCTTTATCAAAGAGTGAATTTCC
AGATCCATCATGAAGGAGGGGAAAATATCAGTGCTTCACCATTAACTAGTAAAGCAGTACAAGAGGATGAAGTAGGTGTTCCAGGTAGCA
ATTCAGCTGACCTATTGCGCTGGACCACTGCTACCACCATGAAAGTCCTTTCCAACACCACAACCACCACCAAAGCGGTGCTGCAGGCCG
TCAGTGATGGGCAGTGGTGGAAGAAGTCTTTAACTTACCTTCGACCCCTTCAGGGGCAAAAATGTGGTGGTGCATATCAAATCGGAACTA
CAGCCAATGAAGATCTAGAGAAACAAGGGTGTCATCCTTTTTATGAATCTGTCATCTCAAATCCTTTTGTCGCTGAGTCTGAAGGGACCT
ATGACACCTATCAGCATGTTCCAGTGGAAAGCTTTGCAGAAGTATTGCTGAGAACTGGAAAATTGGCAGAGGCTAAAAATAAAGGAGAAG
TATTTCCAACAACTGAAGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCTTAC
CACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCCAGA
TCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCAGGC
ATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGGATT
TCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTATCC
TTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTTTTA
TGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGACTT
TGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGTATT
ATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGTTTA
AGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTCAAA
ATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGTTAC
AGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCATGA
AGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAAGGATGGCTGAC
TTCAGGCTGCGGAAACTGAAGGCAATAATGTTGGCTTTTGGAAGGGGCAAGACGAGAAACTCTGAAGAAAGCTCTGACTCTCAGGAAGTT
ATCTGGAAAGATACCTGGATGTTTACTGCCTTGGGACACTGTGGGATCTCCATGTTTGGACTATGGGACAGAGAATTGACCCTAACTAAC
TAACTATGAACTATTTATTTCCTCCTCCCCTACCCCTAGTTAAGTGCCACAAAGACTGTGTTATGTAGTCAGTACTTTTTTCTCATGTAT
CTTTCTCTAGACCATTTATATACGGGTGAAATGAAAGCTTTTTTGCATGTACTTGATACTCAGTCTGTAAACTCAGACTTCGCTTTTTTT
GTGAGACTATCCTTTCAATATTTTTATAAACTTTTGTGTGTGCTGTGGCAGGGAACAGTTAACAAGGAGTTTATTTAGAGGGGTTTTTTT
CATTTTTTGTTTTTCTTGTTTTGTTTTGTTTTGTTTTGTTCTTCTTGGTGTGCTTTTTGGATGGGACCAGAACTTAACATTTTCCTGAGG
ACTAGGAAGCTCATCAGACACTGGAATGCAGTGATTCTTCTAATGATGGTCAACTGCAAGGAGAAACTGTTTACATCCTTCCCACTACAC
AGTTGCTATGATATGTAACAAGTCACACATGTATATATCACACAAGTCTTACCAATTCTGCGTCACTAGGAAGCTATAGCATGGTCGTGA
AAGCTCTCCTAATACTTACTTAAATAGCCATGGAAGAAAATTATGCTTGTCCCTTCTGACTGGGTTAAGCCATCTTTCTTAAGATTCCTG
AAGTAGAAATAGCAATTAAGAAATTAATTCAAGTTTTGACGGTTAACATTTAGCAGAAAAACAAACCATTGAATAAGCTACTAGGTGAAA
TGCAAAACAACCATCAATTTTTTTAAACTCAATAATTTTGTGAAAAAAAAAACCACCACCAAACTTTTGGTTGTAAAAGAGAACCCTTGT
TCCCTTCCTAAGAAACTGCCTTCCACAATTAAAGAATACTCATAGAAAGAAAATAATCATAAATCATATTTGATTAACATTTCATTTAAG
CTTTTAAAATATCAATTTTTTAAATAGCTCCCATTTACCCAAAATAACTAGTTATGGGTCTATTTCTTCCATGATTAGAGGAGAGAGAAC
TTGATTCAAGATACTGAAAAATAGAGCTGGGACTGAGCCTGTGAATGACAGGAATGATCTATTACCAGGTGACTAGTCGGAAACTACACA
GACGTGCACTGGTCTGCATTTGGGGGCTAAAGTGTATATATTCCATTTAAAATGGAATTTGTTTGTATTTGGGGCAGTCTTCAGTAAAGC
CTTTCTCCTTTCTTTTCTCCATTGAGGACAGTTCTGCTCAGCAAAATTGTTGAGTACCTGTTCTGGGCAGGTCCCACGCTATATGCACAA
AGTTAAGAAAAACTTGGTCTTAGCCCTTGGGAGCTGACAGCCCATGGGCATTAAGGCAAAGTAGTTCCAGTGATTTAAAATACGGTTCCA
AATACGCTAAAACCAACTTGTGCCAACCAGATTTACAGATTGGAAATACTGCAGATGATGTGAAGTTATCAGTTGGAGGAGCTGTGATTA
AGCTGGATAATAAGAGAACGTGCCATCTGTAAAGCACTCAGAAGGCAGCCATCCCTAGATGTTGGTTTCATGTATATTACACTATCTACT
ACTATCCATAAATGCAATAATATGCATGTTAACAACATTAAAAACAGCAAACAGCAATCTAAGTACAGAAAAGCTTTTTGTGTGTTTAAA
AAAATTGAAGAAAATTCAGGAAGAAACGTGTTAATAAACATTGTACTGTTCTTTTGCTTCTCAAAGGAATTATTCACTTGCCACTTTGGT
TATTTTTGAGTTTTCGTACATAGGAAGTTTTATATTGCCAGCCTTCCTGTGATAAAGATATTAAATGTAACTTGAGTAAAAAATAAAAAA

>57385_57385_1_NBAS-RASGRP3_NBAS_chr2_15415608_ENST00000281513_RASGRP3_chr2_33787796_ENST00000402538_length(amino acids)=1917AA_BP=
MPESSANMAAPESGPALSPGTAEGEEETILYDLLVNTEWPPETEVQPRGNQKHGASFIITKAIRDRLLFLRQYIWYSPAPFLLPDGLVRL
VNKQINWHLVLASNGKLLAAVQDQCVEIRSAKDDFTSIIGKCQVPKDPKPQWRRVAWSYDCTLLAYAESTGTVRVFDLMGSELFVISPAS
SFIGDLSYAIAGLIFLEYKASAQWSAELLVINYRGELRSYLVSVGTNQSYQESHCFSFSSHYPHGINTAIYHPGHRLLLVGGCETAEVGM
SKASSCGLSAWRVLSGSPYYKQVTNGGDGVTAVPKTLGLLRMLSVKFYSRQGQEQDGIFKMSLSPDGMLLAAIHFSGKLSIWAIPSLKQQ
GEWGQNEQPGYDDLNPDWRLSTEKRKKIKDKESFYPLIDVNWWADSAVTLARCSGALTVSSVKTLKNLLGKSCEWFEPSPQVTATHDGGF
LSLECEIKLAPKRSRLETRAGEEDEGEEDSDSDYEISAKARYFGYIKQGLYLVTEMERFAPPRKRPRTITKNYRLVSLRSTTPEELYQRK
IESEEYEEALSLAHTYGLDTDLVYQRQWRKSAVNVASIQNYLSKIKKRSWVLHECLERVPENVDAAKELLQYGLKGTDLEALLAIGKGAD
DGRFTLPGEIDIDSISYEELSPPDEEPAKNKKEKELKKRQELLKLVNFSKLTLEQKELCRCRRKLLTYLDRLATYEEILGVPHASEQRYD
AEFFKKFRNQNIVLSARTYAQESNVQALEILFTYHGSDLLPHRLAILSNFPETTSPHEYSVLLPEACFNGDSLMIIPWHEHKHRAKDWCE
ELACRMVVEPNLQDESEFLYAAQPELLRFRMTQLTVEKVMDWYQTRAEEIEHYARQVDCALSLIRLGMERNIPGLLVLCDNLVTLETLVY
EARCDVTLTLKELQQMKDIEKLRLLMNSCSEDKYVTSAYQWMVPFLHRCEKQSPGVANELLKEYLVTLAKGDLKFPLKIFQHSKPDLQQK
IIPDQDQLMAIALECIYTCERNDQLCLCYDLLECLPERGYGDKTEATTKLHDMVDQLEQILSVSELLEKHGLEKPISFVKNTQSSSEEAR
KLMVRLTRHTGRKQPPVSESHWRTLLQDMLTMQQNVYTCLDSDACYEIFTESLLCSSRLENIHLAGQMMHCSACSENPPAGIAHKGKPHY
RVSYEKSIDLVLAASREYFNSSTNLTDSCMDLARCCLQLITDRPPAIQEELDLIQAVGCLEEFGVKILPLQVRLCPDRISLIKECISQSP
TCYKQSTKLLGLAELLRVAGENPEERRGQVLILLVEQALRFHDYKAASMHCQELMATGYPKSWDVCSQLGQSEGYQDLATRQELMAFALT
HCPPSSIELLLAASSSLQTEILYQRVNFQIHHEGGENISASPLTSKAVQEDEVGVPGSNSADLLRWTTATTMKVLSNTTTTTKAVLQAVS
DGQWWKKSLTYLRPLQGQKCGGAYQIGTTANEDLEKQGCHPFYESVISNPFVAESEGTYDTYQHVPVESFAEVLLRTGKLAEAKNKGEVF
PTTEVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAPCFRDKCHPLYRADPKELIKMVTRHV
TRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETLEESVYSIAISLAQRYSVSRWEVFMT
HLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLENCGCADLGNCAIKPETHIRLLKKFKV
VASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTGDPHLIKQVPGSSPEWLHAYDVCMKY

--------------------------------------------------------------
>57385_57385_2_NBAS-RASGRP3_NBAS_chr2_15415608_ENST00000441750_RASGRP3_chr2_33787796_ENST00000402538_length(transcript)=7412nt_BP=5390nt
CTCCGCTGCCTGAGTCCTCGGCGAACATGGCGGCCCCCGAGTCAGGGCCGGCTTTGAGTCCAGGCACTGCAGAGGGTGAGGAGGAGACGA
TTCTCTATGACTTGTTGGTCAACACCGAGTGGCCACCGGAGACTGAAGTACAGCCTAGAGGCAACCAAAAACATGGTGCATCCTTTATCA
TCACGAAAGCAATTCGAGATCGTTTATTATTTTTACGCCAATACATCTGGTACAGCCCGGCACCTTTTTTGCTCCCTGATGGACTGGTTC
GCTTGGTTAATAAACAGATAAACTGGCATTTGGTACTTGCAAGCAATGGAAAGCTTTTGGCTGCTGTTCAAGATCAGTGTGTGGAAATCA
GGTCTGCAAAAGATGATTTTACATCCATTATTGGGAAATGTCAAGTTCCGAAAGACCCGAAACCCCAGTGGAGACGGGTAGCATGGAGTT
ACGATTGTACCCTACTGGCCTATGCCGAAAGCACAGGAACTGTGAGGGTGTTTGATCTCATGGGAAGTGAACTCTTTGTCATTTCCCCGG
CATCTAGTTTTATAGGTGACTTAAGCTATGCCATTGCTGGGTTGATATTTTTAGAATATAAAGCAAGTGCACAGTGGTCTGCAGAACTCC
TGGTCATCAATTACCGAGGAGAACTTAGAAGTTACCTTGTAAGTGTTGGAACAAATCAGAGCTACCAAGAAAGTCACTGTTTCAGCTTCA
GTAGTCATTATCCTCATGGAATCAACACAGCTATTTACCACCCTGGTCACAGACTTTTACTTGTTGGTGGATGTGAAACTGCTGAAGTAG
GCATGTCAAAAGCTTCTAGCTGTGGCCTTTCTGCCTGGAGAGTTCTTTCAGGATCACCGTATTATAAGCAGGTTACTAATGGTGGAGACG
GGGTTACTGCAGTACCGAAGACACTGGGATTATTAAGGATGTTAAGTGTCAAGTTTTACAGTCGCCAGGGACAAGAACAGGATGGAATTT
TTAAGATGAGCCTTTCTCCAGATGGGATGCTCCTGGCAGCCATTCACTTCTCAGGGAAACTGAGCATCTGGGCGATTCCATCTCTGAAGC
AACAAGGGGAATGGGGTCAAAATGAGCAGCCAGGCTATGATGACCTTAATCCTGATTGGAGGCTCTCTACTGAGAAGAGAAAAAAAATCA
AAGATAAAGAGTCCTTTTACCCACTGATAGATGTCAATTGGTGGGCAGACAGTGCAGTGACTTTAGCTCGATGCTCTGGTGCTTTAACTG
TTTCATCTGTGAAAACTTTGAAGAATTTACTGGGAAAATCCTGTGAATGGTTTGAACCATCACCTCAAGTCACTGCTACCCATGATGGGG
GATTTTTAAGTTTGGAGTGTGAGATTAAACTTGCCCCCAAACGATCTCGTTTGGAGACTAGAGCTGGAGAAGAAGATGAAGGAGAAGAGG
ATTCTGATTCTGATTATGAAATATCTGCCAAGGCTCGCTACTTTGGTTATATAAAACAGGGCCTTTACTTGGTGACTGAAATGGAGCGAT
TTGCACCACCACGGAAACGCCCACGAACCATTACTAAAAACTACCGCCTTGTGAGTTTGCGCTCCACGACACCAGAGGAACTTTATCAGA
GGAAGATTGAAAGTGAAGAGTATGAGGAAGCCTTGTCCTTGGCTCATACCTACGGCCTGGATACTGACCTTGTATATCAGAGGCAGTGGA
GGAAGTCAGCGGTCAACGTTGCTTCAATTCAGAATTATTTGAGTAAAATAAAGAAGCGATCCTGGGTTCTCCATGAGTGTTTGGAAAGAG
TTCCTGAAAATGTGGATGCTGCAAAAGAACTGCTTCAGTATGGATTAAAAGGCACAGACCTGGAGGCTCTTTTAGCAATAGGGAAAGGAG
CAGATGATGGCAGATTTACATTACCTGGTGAAATAGACATTGACAGTATCTCCTATGAAGAGCTTTCACCACCTGATGAAGAGCCTGCCA
AGAATAAAAAGGAAAAGGAGCTCAAGAAGAGACAAGAACTACTGAAATTAGTGAACTTTTCCAAGTTGACACTGGAACAAAAGGAACTTT
GCCGTTGTAGACGGAAGTTATTAACCTACTTAGATCGACTTGCAACATATGAGGAAATCCTAGGAGTGCCTCATGCATCTGAACAGAGAT
ATGATGCTGAATTCTTTAAGAAATTCAGAAATCAGAATATTGTTCTCTCAGCAAGAACTTATGCTCAGGAAAGTAATGTACAAGCCCTGG
AAATTCTGTTTACTTACCATGGTTCCGACCTGCTTCCTCATCGCCTTGCAATTCTGTCCAACTTTCCAGAGACCACTTCTCCACATGAAT
ATTCTGTTTTGCTGCCCGAAGCTTGTTTTAACGGTGACTCCCTGATGATCATTCCTTGGCATGAACATAAACACCGAGCTAAAGATTGGT
GCGAGGAGTTGGCTTGCAGAATGGTTGTTGAGCCGAATCTCCAAGATGAAAGTGAATTCTTGTATGCTGCACAGCCTGAGTTACTAAGGT
TCAGGATGACCCAGCTTACGGTGGAGAAGGTTATGGACTGGTATCAGACCAGAGCAGAGGAAATAGAGCATTATGCTCGGCAGCTGCAGC
AAAAAATTATTCCTGATCAGGACCAACTGATGGCAATAGCACTAGAGTGCATCTATACCTGTGAACGAAATGATCAACTCTGTCTTTGCT
ATGACCTACTAGAATGTCTGCCAGAAAGAGGATATGGTGATAAGACAGAGGCAACCACAAAGCTTCATGACATGGTAGACCAACTGGAAC
AAATTCTCAGTGTGTCAGAGCTTTTGGAAAAACATGGACTCGAGAAACCAATTTCATTTGTTAAAAACACTCAATCTAGCTCAGAAGAGG
CACGCAAGCTGATGGTTAGATTGACGAGGCACACTGGCCGGAAGCAGCCTCCTGTCAGTGAGTCTCATTGGAGAACGTTGCTGCAAGACA
TGTTAACTATGCAGCAGAATGTATACACATGTCTAGATTCTGATGCCTGCTATGAGATATTTACAGAAAGCCTTCTGTGCTCTAGTCGCC
TTGAAAACATCCACCTGGCTGGACAGATGATGCACTGCAGTGCTTGTTCAGAAAATCCTCCAGCTGGTATAGCCCATAAAGGGAAACCCC
ACTACAGGGTCAGCTACGAAAAGAGTATTGACTTGGTTTTGGCTGCCAGCAGAGAGTACTTCAATTCTTCTACCAACCTCACTGATAGCT
GCATGGATCTAGCCAGGTGCTGCTTACAACTGATAACAGACAGACCCCCTGCCATTCAAGAGGAGCTAGATCTTATCCAAGCCGTTGGAT
GTCTTGAAGAATTTGGGGTAAAGATCCTGCCTTTGCAAGTGCGATTGTGCCCTGATCGGATCAGTCTCATCAAGGAGTGTATTTCCCAGT
CCCCCACATGCTATAAACAATCCACCAAGCTTCTGGGCCTTGCTGAGCTGCTGAGGGTTGCAGGTGAGAACCCAGAAGAAAGGCGGGGAC
AGGTTCTAATCCTTTTAGTGGAGCAGGCACTTCGCTTCCATGACTACAAAGCAGCCAGTATGCATTGTCAGGAGCTGATGGCCACAGGTT
ATCCTAAAAGTTGGGATGTTTGTAGCCAGTTAGGACAATCAGAAGGTTACCAGGACTTGGCCACTCGTCAAGAGCTCATGGCTTTTGCTT
TGACACATTGCCCTCCTAGCAGCATTGAACTTCTTTTGGCAGCTAGCAGCTCTCTGCAGACAGAAATTCTTTATCAAAGAGTGAATTTCC
AGATCCATCATGAAGGAGGGGAAAATATCAGTGCTTCACCATTAACTAGTAAAGCAGTACAAGAGGATGAAGTAGGTGTTCCAGGTAGCA
ATTCAGCTGACCTATTGCGCTGGACCACTGCTACCACCATGAAAGTCCTTTCCAACACCACAACCACCACCAAAGCGGTGCTGCAGGCCG
TCAGTGATGGGCAGTGGTGGAAGAAGTCTTTAACTTACCTTCGACCCCTTCAGGGGCAAAAATGTGGTGGTGCATATCAAATCGGAACTA
CAGCCAATGAAGATCTAGAGAAACAAGGGTGTCATCCTTTTTATGAATCTGTCATCTCAAATCCTTTTGTCGCTGAGTCTGAAGGGACCT
ATGACACCTATCAGCATGTTCCAGTGGAAAGCTTTGCAGAAGTATTGCTGAGAACTGGAAAATTGGCAGAGGCTAAAAATAAAGGAGAAG
TATTTCCAACAACTGAAGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCTTAC
CACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCCAGA
TCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCAGGC
ATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGGATT
TCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTATCC
TTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTTTTA
TGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGACTT
TGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGTATT
ATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGTTTA
AGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTCAAA
ATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGTTAC
AGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCATGA
AGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAAGGATGGCTGAC
TTCAGGCTGCGGAAACTGAAGGCAATAATGTTGGCTTTTGGAAGGGGCAAGACGAGAAACTCTGAAGAAAGCTCTGACTCTCAGGAAGTT
ATCTGGAAAGATACCTGGATGTTTACTGCCTTGGGACACTGTGGGATCTCCATGTTTGGACTATGGGACAGAGAATTGACCCTAACTAAC
TAACTATGAACTATTTATTTCCTCCTCCCCTACCCCTAGTTAAGTGCCACAAAGACTGTGTTATGTAGTCAGTACTTTTTTCTCATGTAT
CTTTCTCTAGACCATTTATATACGGGTGAAATGAAAGCTTTTTTGCATGTACTTGATACTCAGTCTGTAAACTCAGACTTCGCTTTTTTT
GTGAGACTATCCTTTCAATATTTTTATAAACTTTTGTGTGTGCTGTGGCAGGGAACAGTTAACAAGGAGTTTATTTAGAGGGGTTTTTTT
CATTTTTTGTTTTTCTTGTTTTGTTTTGTTTTGTTTTGTTCTTCTTGGTGTGCTTTTTGGATGGGACCAGAACTTAACATTTTCCTGAGG
ACTAGGAAGCTCATCAGACACTGGAATGCAGTGATTCTTCTAATGATGGTCAACTGCAAGGAGAAACTGTTTACATCCTTCCCACTACAC
AGTTGCTATGATATGTAACAAGTCACACATGTATATATCACACAAGTCTTACCAATTCTGCGTCACTAGGAAGCTATAGCATGGTCGTGA
AAGCTCTCCTAATACTTACTTAAATAGCCATGGAAGAAAATTATGCTTGTCCCTTCTGACTGGGTTAAGCCATCTTTCTTAAGATTCCTG
AAGTAGAAATAGCAATTAAGAAATTAATTCAAGTTTTGACGGTTAACATTTAGCAGAAAAACAAACCATTGAATAAGCTACTAGGTGAAA
TGCAAAACAACCATCAATTTTTTTAAACTCAATAATTTTGTGAAAAAAAAAACCACCACCAAACTTTTGGTTGTAAAAGAGAACCCTTGT
TCCCTTCCTAAGAAACTGCCTTCCACAATTAAAGAATACTCATAGAAAGAAAATAATCATAAATCATATTTGATTAACATTTCATTTAAG
CTTTTAAAATATCAATTTTTTAAATAGCTCCCATTTACCCAAAATAACTAGTTATGGGTCTATTTCTTCCATGATTAGAGGAGAGAGAAC
TTGATTCAAGATACTGAAAAATAGAGCTGGGACTGAGCCTGTGAATGACAGGAATGATCTATTACCAGGTGACTAGTCGGAAACTACACA
GACGTGCACTGGTCTGCATTTGGGGGCTAAAGTGTATATATTCCATTTAAAATGGAATTTGTTTGTATTTGGGGCAGTCTTCAGTAAAGC
CTTTCTCCTTTCTTTTCTCCATTGAGGACAGTTCTGCTCAGCAAAATTGTTGAGTACCTGTTCTGGGCAGGTCCCACGCTATATGCACAA
AGTTAAGAAAAACTTGGTCTTAGCCCTTGGGAGCTGACAGCCCATGGGCATTAAGGCAAAGTAGTTCCAGTGATTTAAAATACGGTTCCA
AATACGCTAAAACCAACTTGTGCCAACCAGATTTACAGATTGGAAATACTGCAGATGATGTGAAGTTATCAGTTGGAGGAGCTGTGATTA
AGCTGGATAATAAGAGAACGTGCCATCTGTAAAGCACTCAGAAGGCAGCCATCCCTAGATGTTGGTTTCATGTATATTACACTATCTACT
ACTATCCATAAATGCAATAATATGCATGTTAACAACATTAAAAACAGCAAACAGCAATCTAAGTACAGAAAAGCTTTTTGTGTGTTTAAA
AAAATTGAAGAAAATTCAGGAAGAAACGTGTTAATAAACATTGTACTGTTCTTTTGCTTCTCAAAGGAATTATTCACTTGCCACTTTGGT
TATTTTTGAGTTTTCGTACATAGGAAGTTTTATATTGCCAGCCTTCCTGTGATAAAGATATTAAATGTAACTTGAGTAAAAAATAAAAAA

>57385_57385_2_NBAS-RASGRP3_NBAS_chr2_15415608_ENST00000441750_RASGRP3_chr2_33787796_ENST00000402538_length(amino acids)=1797AA_BP=
MPESSANMAAPESGPALSPGTAEGEEETILYDLLVNTEWPPETEVQPRGNQKHGASFIITKAIRDRLLFLRQYIWYSPAPFLLPDGLVRL
VNKQINWHLVLASNGKLLAAVQDQCVEIRSAKDDFTSIIGKCQVPKDPKPQWRRVAWSYDCTLLAYAESTGTVRVFDLMGSELFVISPAS
SFIGDLSYAIAGLIFLEYKASAQWSAELLVINYRGELRSYLVSVGTNQSYQESHCFSFSSHYPHGINTAIYHPGHRLLLVGGCETAEVGM
SKASSCGLSAWRVLSGSPYYKQVTNGGDGVTAVPKTLGLLRMLSVKFYSRQGQEQDGIFKMSLSPDGMLLAAIHFSGKLSIWAIPSLKQQ
GEWGQNEQPGYDDLNPDWRLSTEKRKKIKDKESFYPLIDVNWWADSAVTLARCSGALTVSSVKTLKNLLGKSCEWFEPSPQVTATHDGGF
LSLECEIKLAPKRSRLETRAGEEDEGEEDSDSDYEISAKARYFGYIKQGLYLVTEMERFAPPRKRPRTITKNYRLVSLRSTTPEELYQRK
IESEEYEEALSLAHTYGLDTDLVYQRQWRKSAVNVASIQNYLSKIKKRSWVLHECLERVPENVDAAKELLQYGLKGTDLEALLAIGKGAD
DGRFTLPGEIDIDSISYEELSPPDEEPAKNKKEKELKKRQELLKLVNFSKLTLEQKELCRCRRKLLTYLDRLATYEEILGVPHASEQRYD
AEFFKKFRNQNIVLSARTYAQESNVQALEILFTYHGSDLLPHRLAILSNFPETTSPHEYSVLLPEACFNGDSLMIIPWHEHKHRAKDWCE
ELACRMVVEPNLQDESEFLYAAQPELLRFRMTQLTVEKVMDWYQTRAEEIEHYARQLQQKIIPDQDQLMAIALECIYTCERNDQLCLCYD
LLECLPERGYGDKTEATTKLHDMVDQLEQILSVSELLEKHGLEKPISFVKNTQSSSEEARKLMVRLTRHTGRKQPPVSESHWRTLLQDML
TMQQNVYTCLDSDACYEIFTESLLCSSRLENIHLAGQMMHCSACSENPPAGIAHKGKPHYRVSYEKSIDLVLAASREYFNSSTNLTDSCM
DLARCCLQLITDRPPAIQEELDLIQAVGCLEEFGVKILPLQVRLCPDRISLIKECISQSPTCYKQSTKLLGLAELLRVAGENPEERRGQV
LILLVEQALRFHDYKAASMHCQELMATGYPKSWDVCSQLGQSEGYQDLATRQELMAFALTHCPPSSIELLLAASSSLQTEILYQRVNFQI
HHEGGENISASPLTSKAVQEDEVGVPGSNSADLLRWTTATTMKVLSNTTTTTKAVLQAVSDGQWWKKSLTYLRPLQGQKCGGAYQIGTTA
NEDLEKQGCHPFYESVISNPFVAESEGTYDTYQHVPVESFAEVLLRTGKLAEAKNKGEVFPTTEVLLQLASEALPNDMTLALAYLLALPQ
VLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAPCFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFT
QAQILQGLRKGVDVQRFTADDQYKRETILGLAETLEESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLK
TDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLENCGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NBAS-RASGRP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNBASchr2:15415608chr2:33787796ENST00000281513-44521_10351908.02372.0USE1L
HgeneNBASchr2:15415608chr2:33787796ENST00000441750-42501_10351788.02252.0USE1L


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNBASchr2:15415608chr2:33787796ENST00000281513-44521036_23711908.02372.0ZW10 and RINT1
HgeneNBASchr2:15415608chr2:33787796ENST00000441750-42501036_23711788.02252.0ZW10 and RINT1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NBAS-RASGRP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NBAS-RASGRP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource