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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NBEAL1-MLLT3 (FusionGDB2 ID:57415)

Fusion Gene Summary for NBEAL1-MLLT3

check button Fusion gene summary
Fusion gene informationFusion gene name: NBEAL1-MLLT3
Fusion gene ID: 57415
HgeneTgene
Gene symbol

NBEAL1

MLLT3

Gene ID

65065

4300

Gene nameneurobeachin like 1MLLT3 super elongation complex subunit
SynonymsA530083I02Rik|ALS2CR16|ALS2CR17AF9|YEATS3
Cytomap

2q33.2

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionneurobeachin-like protein 1amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 16amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 17amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 proteinprotein AF-9ALL1-fused gene from chromosome 9 proteinKMT2A/MLLT3 fusionKMT2A/MLLT3 fusion proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leu
Modification date2020031320200327
UniProtAcc

Q6ZS30

P42568

Ensembl transtripts involved in fusion geneENST00000449802, ENST00000478884, 
ENST00000355930, ENST00000380321, 
ENST00000429426, ENST00000475957, 
ENST00000380338, 
Fusion gene scores* DoF score11 X 11 X 7=84718 X 37 X 9=5994
# samples 1235
** MAII scorelog2(12/847*10)=-2.81932756372368
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/5994*10)=-4.09809225668125
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NBEAL1 [Title/Abstract] AND MLLT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNBEAL1(204067504)-MLLT3(20365742), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMLLT3

GO:0045893

positive regulation of transcription, DNA-templated

25417107|27105114

TgeneMLLT3

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591803


check buttonFusion gene breakpoints across NBEAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MLLT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-68-7755-01ANBEAL1chr2

204067504

-MLLT3chr9

20365742

-
ChimerDB4LUSCTCGA-68-7755-01ANBEAL1chr2

204067504

+MLLT3chr9

20365742

-
ChimerDB4LUSCTCGA-68-7755NBEAL1chr2

204067504

+MLLT3chr9

20365742

-


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Fusion Gene ORF analysis for NBEAL1-MLLT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000449802ENST00000355930NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
5CDS-5UTRENST00000449802ENST00000380321NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
5CDS-5UTRENST00000449802ENST00000429426NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
5CDS-5UTRENST00000449802ENST00000475957NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
In-frameENST00000449802ENST00000380338NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
intron-3CDSENST00000478884ENST00000380338NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
intron-5UTRENST00000478884ENST00000355930NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
intron-5UTRENST00000478884ENST00000380321NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
intron-5UTRENST00000478884ENST00000429426NBEAL1chr2

204067504

+MLLT3chr9

20365742

-
intron-5UTRENST00000478884ENST00000475957NBEAL1chr2

204067504

+MLLT3chr9

20365742

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449802NBEAL1chr2204067504+ENST00000380338MLLT3chr920365742-13112775233383332666

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449802ENST00000380338NBEAL1chr2204067504+MLLT3chr920365742-0.0002282460.9997718

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Fusion Genomic Features for NBEAL1-MLLT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NBEAL1-MLLT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:204067504/chr9:20365742)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBEAL1

Q6ZS30

MLLT3

P42568

FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNBEAL1chr2:204067504chr9:20365742ENST00000449802+50551883_198024732695.0DomainBEACH-type PH
HgeneNBEAL1chr2:204067504chr9:20365742ENST00000449802+50551992_228424732695.0DomainBEACH
TgeneMLLT3chr2:204067504chr9:20365742ENST00000380338411383_391375569.0Compositional biasNote=Poly-Ser
TgeneMLLT3chr2:204067504chr9:20365742ENST00000380338411466_469375569.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNBEAL1chr2:204067504chr9:20365742ENST00000449802+50552439_247824732695.0RepeatNote=WD 1
HgeneNBEAL1chr2:204067504chr9:20365742ENST00000449802+50552490_253124732695.0RepeatNote=WD 2
TgeneMLLT3chr2:204067504chr9:20365742ENST00000380338411149_194375569.0Compositional biasNote=Poly-Ser
TgeneMLLT3chr2:204067504chr9:20365742ENST000003803384111_138375569.0DomainYEATS
TgeneMLLT3chr2:204067504chr9:20365742ENST00000380338411295_300375569.0MotifNuclear localization signal
TgeneMLLT3chr2:204067504chr9:20365742ENST00000380338411106_108375569.0RegionHistone H3K9cr binding
TgeneMLLT3chr2:204067504chr9:20365742ENST00000380338411106_109375569.0RegionInhibitor XL-07i binding
TgeneMLLT3chr2:204067504chr9:20365742ENST0000038033841156_58375569.0RegionInhibitor XL-07i binding
TgeneMLLT3chr2:204067504chr9:20365742ENST0000038033841178_80375569.0RegionHistone H3K9cr binding


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Fusion Gene Sequence for NBEAL1-MLLT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57415_57415_1_NBEAL1-MLLT3_NBEAL1_chr2_204067504_ENST00000449802_MLLT3_chr9_20365742_ENST00000380338_length(transcript)=13112nt_BP=7752nt
GCTCGTCTGCCTGGCTGCGGGGTGACACGGGGCTTCGCCTTGGGAAGGGGTCGAGGGAAGCAGTTAGACGGCTGCCGGGCGGCGGCTGCC
GCGCGGCACACAATATTTATTTAATTGCCCAACTACCACTGATGAAGATATATTGGAGTGACTGCTGAAATTGCCTTTTTGTTTTTAACC
AGAGGACAGTCCATTTGTTTCACTTCTTTTTGCTTTCTTTACTGCTATGAGCTTTACTGAACGGCTGAAAAACTTGGAAAATAAAATGGA
CATGCTGTAGTCTTGAACATAATTTTTTTAAGGAAAACTTAAAGTGCCAGAGTGAAAGCCAGAATGGCATCCAGAGAGAGGCTCTTTGAA
CTTTGGATGCTTTATTGTACAAAGAAAGATCCAGATTACCTGAAGCTGTGGTTGGACACTTTTGTTTCTAGCTATGAACAATTTTTAGAC
GTTGACTTTGAAAAGCTGCCTACCAGGGTAGATGATATGCCTCCAGGAATATCTCTGCTTCCTGATAATATTCTGCAGGTTCTGAGGATC
CAGCTTCTACAGTGTGTTCAGAAAATGGCAGATGGGTTAGAGGAACAACAGCAAGCCTTGTCAATTTTGCTTGTCAAGTTCTTCATTATT
CTTTGCAGAAATCTATCAAATGTGGAAGAAATTGGGACTTGCTCGTACATTAATTATGTCATCACCATGACAACACTCTATATTCAGCAA
TTAAAAAGCAAAAAAAAAGAGAAGGAAATGGCAGATCAGACATGTATTGAAGAATTTGTGATCCACGCATTGGCATTTTGTGAAAGCTTA
TATGATCCATATCGGAATTGGAGACATAGAATTTCAGGACGAATCCTTAGTACTGTGGAAAAGAGCAGACAGAAATATAAACCAGCTTCT
CTCACAGTGGAATTCGTCCCTTTCTTTTATCAATGTTTTCAGGAAAGTGAACATCTCAAGGAAAGTCTTAAATGTTGCTTATTGCATCTC
TTTGGAGCCATTGTAGCCGGTGGGCAGAGGAATGCTTTGCAAGCAATTTCTCCAGCCACTATGGAAGTTCTTATGCGAGTATTGGCAGAT
TGTGATTCCTGGGAGGATGGAGATCCTGAAGAAGTGGGTAGGAAGGCAGAACTAACTCTGAAGTGCCTTACAGAAGTGGTACATATCCTT
CTCAGTAGCAACTCTGATCAGCGTCAAGTGGAAACCAGTACTATTCTGGAGAACTATTTTAAATTGCTAAATTCAGATCATTCAGCTTTA
CCTAATCAAAGGAGGTCCAGACAGTGGGAAAACCGATTTATTGCTCTACAGATCAAAATGCTGAATACCATCACAGCCATGTTAGATTGT
ACAGATAGACCTGTTCTTCAGGCCATTTTTCTTAACAGCAATTGCTTTGAACATCTCATACGACTGCTACAGAACTGCAAGGTGTTTCAG
GGACAATTGGATTGTTTGGCCATATCAACCATTCAGGCTTTGACCGCAGTAATGAACAAATCTCCAGCTGCTAAGGAAGTATTTAAAGAA
AGAATTGGTTATACACATATGCTTGAAGTATTAAAATCCCTGGGTCAGCCACCACTGGAATTACTTAAAGAACTTATGAATATGGCTGTA
GAGGGTGACCACACTTCAGTTGGGATTTTGGGCATTAGTAATGTCCAACCTCTCTTGCTTCTTATCCAGTGGCTTCCAGAACTACAATCC
CATGACCTGCAAATCTTCATCTCTGATTGGCTGAAAAGAATTTGTTGTATTAATAGACAGAGTCGAACTACTTGTGTCAATGCAAACATG
GGGATTAGAATCATTGAAACCCTTGACTTGCATTCTTCCCTCCATCAAACTTGTGCTGAGAACTTGATTGCAATCCATGGTTCCTTGGGG
AGTCAGTCAGTGAGCTCAGAAGAAATCCGTCGACTACTGAGATTGCTGAGAGTGGATGAATCTGAGTCTGTTCACCCTTATGTCACTCCC
GTGACTCGAGCAATCCTGACAATGGCCCGAAAACTAAGTCTAGAGAGTGCCCTCCAGTATTTCAATTTGTCACATAGTATGGCAGGAATT
TCTGTGCCTCCCATACAGAAATGGCCAGGGTCTGCCTTTTCTTTCAGTGCTTGGTTTTGCTTAGACCAGGATCAGTTGACTCTTGGCATT
GCTAACAAAGGAGGGAAAAGGAAACAATTGTACAGTTTTTTTACAGGAAGTGGCATGGGTTTTGAAGCCTTTATTACCCATTCAGGTATG
TTGGTCGTGGCAGTGTGCACAAAAAGAGAATATGCAACGGTTATGCTTCCTGACCACAGTTTCTGTGATTCCCTCTGGCACAACATAACT
GTTGTCCACATGCCTGGAAAAAGGCCTTTTGGTCAGAGCTTCGTCTATATCTATGACAATGGACAACAGAAGGTTTCTGCCCCTCTCAGA
TTTCCTGCCATGAATGAACCCTTTACTTCCTGTTGCATTGGTTCAGCTGGGCAAAGAACCACCACTCCTCCACCATCCCAAATCCCAGAT
CCACCTTTCTCTTCTCCCATTACCCCTCATCGGACATCATTTGGTGGAATTCTGTCATCAGCCTCCTGGGGAGGAACAATTGAAAAATCA
AAATTGATTACCAAATTGATATCAGCTGGAACCCAAGACAGTGAATGGGGGTGTCCCACATCTCTGGAGGGTCAGCTAGGATCTGTTATC
ATCTTTTATGAACCACTACAACCTCCTCAGGTGAAGGCATTATATTTAGCAGGTCCAAATTGTTTAAGCCCTTGGAAGTGTCAAGAGTCT
GACATGGCCGACCTGCCTGGTAACATCCTTCTTTACTACACAGCAAAGGCCTGCAAAAATTCAATCTGTCTTGATTTATCTACTAATTGT
TTGCATGGAAGATTAACAGGAAACAAAGTAGTGAACTGGGACATTAAGGATATCATAAACTGCATAGGTGGGTTAAATGTACTCTTTCCT
TTATTGGAACAAATCAGCCACTTTAGTGAAGGACAGATTCCTGAAGAAAAGAATGAAAGCACAGTTCCTGAATCAGTAACACCTGTTGAA
GGAGATTGGCTCGTATGGACTTCCACAAAGGCCTCAGAGTCAAGACTAGAGAGAAACCTAGTTGCAACATTTATCTTAATTGTGAAACAT
TTTATTCAGAGACATCCTATCAACCAGGGCAATCTTATTCACTCCCATGGAGTTGCAACTCTTGGTGCTTTACTTCAGAAGGTGCCAAGC
ACCTTGATGGATGTTAATGTGTTGATGGCAGTTCAGTTACTAATTGAACAAGTATCATTAGAGAAAAATATGCAGCTCCTGCAACAAATG
TATCAATATTTACTCTTTGACTTTCGTATTTGGAACCGTGGAGATTTTCCCTTTCGAATCGGTCACATACAGTATCTTTCAACCATCATT
AAAGACAGCAGGAGAGTTTTCCGAAAGAAGTATGGTGTGCAGTTTCTCCTAGATACACTTAGGATTTATTATGGGAATGGTTGTAAATAT
AATGAACTATCTCTAGATGATATTCGAACAATAAGGACTTCTTTGTATGGACTAATTAAATATTTTCTGTGCAAAGGTGGATCTCATGAA
GAGATACAAAGTATTATGGGGTACATAGCTGCTACTAATGAAGAAGAACAGCTCTTTGGAATTTTGGACGTGCTCTTCAGTCTCCTACGT
ACCAGCCCAACCAGAGGTCAGCTTTTCTTACTGCTTTTTGAACCAGGAAATGCTGACATACTGTACGCATTGCTCTTAAATCAGAAGTAC
TCTGACAGACTAAGAGAAATCATTTTTAAGATTATGGAACAAATGTTGAAATGCACGAACGTTTATGAGCGTAGTAAACAACATATTCGA
CTCAGAGAAGTTGGCTACTCGGGACTGGGACTCCTTCTTAATGAAGCACTTGTTAATACTTCTCTTATTAAAAACCTCACCCATCAAATC
ATAAATACAGATCCTGTTATTAATTTCAAAGATCTACTATCTGTGGTATATATATCTCACAGAGCACATATAAATGTTAGAGTGGCCATC
TGCAGAAAGGTTTTGCAAATTTTGCAGTTCCAGCCAGATGCAGCACATCAAATATCACAGCAAGTGGGTTGGCAAGACACCTTAGTTAGG
CTTTTTTTAAAAGCAAAATTTGAAAACGGAAATACTCTTCATAAGCACAGTAGAGCTGTTTTAATGAAAGACAATGATAAAAATATGTCA
ACTGAAGATACCAAGAAGAACTCTGATGAAAAAACAGATGAGGAAAAAATCACCTCTTTTGCCTCAGCTAATGTGTCTTCGGATCAGTGG
AGTTTGGAGGATAGACACTCTTTAGACTCAAACACACCATTATTTCCAGAAGATAGCTCTGTGGGAGAATTGTCTTTCAAATCAGAGAAT
CAAGAGGAATTCTGGCATAGTAACCCTTCACATTTGAGTTTAGACCTCAGTGGAATTGACTCATGTGAAATGAGTGATAGTGGAAGTCAA
GTGCCAGACAGTCTGCCTAGCACACCATCCCCAGTAGAGTCTACTAAATCGTTTTCTGTGCACTCTGACAGAGAAAGCAGCATCACAAAT
GATATGGGCTTTAGTGATGACTTCTCTTTACTTGAAAGCCAAGAGAGATGTGAGGAGGAGCTTCTTCAATTACTGACACATATTTTGAAT
TATGTAATGTGTAAGGGACTAGAAAAGTCTGATGATGATACTTGGATTGAACGAGGACAAGTGTTTTCAGCACTAAGTAAACCAGGAATA
TCCAGTGAACTACTTCGACCATCAGATGAAATAAAACTAACTTTGCTACAAAAGATGTTAGAATGGGCAATCTCAGAAAACAGAGAAGCA
AAAACTAATCCAGTAACTGCTGAAAACGCCTTCCGACTAGTGCTGATCATACAGGACTTTCTTCAGTCAGAGGGACTAGTTAATTCAAAC
ATGTGGACCGAGAAGCTTTTAGAGGATATGATGCTGCTCTTTGACTGTCTGTCAGTCTGCTATTCTGAAAGTCCAGTATGGGTAAAACTC
TCTCAAATTCAGATCCAGTTGCTTCTAGGATTCATTGGAAGGGGTAATTTGCAGGTTTGTGCAATGGCATCAGCTAAGCTAAATACCCTT
CTTCAGACCAAAGTGATTGAAAATCAGGATGAAGCATGTTACATTTTAGGGAAGCTGGAACATGTTCTAAGTCAATCAATCAAGGAACAG
ACTGAAATCTACTCATTTCTGATTCCCCTTGTTCGTACCCTGGTTTCCAAAATTTATGAGCTTCTCTTCATGAACTTGCACCTACCTTCT
TTACCTTTTACCAATGGTAGCTCCTCATTTTTTGAAGATTTTCAAGAATATTGTAATTCAAATGAATGGCAAGTTTACATTGAAAAATAT
ATTGTACCTTATATGAAGCAGTATGAAGCTCATACATTTTACGATGGTCATGAGAACATGGCACTTTATTGGAAGGATTGTTATGAAGCT
TTAATGGTAAATATGCATAAACGAGACCGGGAAGGAGGGGAAAGCAAGCTCAAATTTCAGGAGCTGTTTGTGGAGCCATTTAATCGAAAA
GCACGCCAAGAGAACCTGAGGTATAATAATATGCTTAAACAACTTAGCAGTCAACAGTTAGCCACTCTTAGACGCTGGAAAGCAATACAG
CTCTATCTTACATGTGAAAGGGGACCTTGGGCTAAAAGGAAACAGAATCCAATTCACTGGAAGCTAGCTAATGTAGAGAATTATTCCCGC
ATGAGACTTAAGCTGGTACCGAATTATAATTTCAAAACCCATGAGGAAGCTAGTGCCTTGAGAGATAATCTGGGTATCCAACACTCACAG
CCTTCCAGTGATACATTGCTTTTGGAAGTAGTGAAACAAGTAAAAGTTAGTGATATGGTGGAGGATAAATTAGACCTTCCTGAAGAGGAT
ATAACAGCTAGAGTAAATGTTGATGAGAAAGAAGAACAGGATCAAAAAGAAAAATTGGTATTGATGGAAGACTGTGAACTCATTACAATA
ATTGATGTAATTCCTGGCAGATTAGAAATCACTACTCAACACATTTACTTCTATGATGGCAGCATTGAAAAAGAAGATGGAGTAGGCTTT
GATTTCAAGTGGCCTCATTCTCAAATTCGAGAGATTCATCTCCGGCGTTACAATTTAAGAAGATCAGCCCTTGAGATTTTTCATGTTGAC
CAATCCAACTACTTTCTCAATTTCAAAAAAGAGGTTAGAAACAAAATATATAGCCGACTGTTGTCACTTCATTCCCCAAATAGTTATTAT
GGAAGCAGATCACCACAGGAGTTATTCAAAGCATCAGGATTGACACAGAAATGGGTAAACAGAGAGATATCAAATTTTGACTACCTCATT
CAAATAAATACAATGGCAGGACGAACCTATAATGACCTTGCACAGTATCCTGTGTTTCCCTGGATTTTACAAGATTATACTTCGGAAGAG
TTGGACCTTAATAACCCTGCTGTATTTCGAGATCTTTCCAAACCAATTGGGGTAGTTAATGAAAAAAACGCCAAAGCTATGAGAGAAAAA
TATGAAAATTTTGAGGATCCTATGGGAACTATTGATAAGTTTCACTATGGTACTCACTATTCAAATTCTGCGGGGGTCATGCACTATCTC
ATTCGTGTAGAACCGTTCACCACCCTCCACATCCAACTTCAGAGTGGAAGGTTTGACTGTGCAGATCGACAGTTCCATTCTATTCCTGCT
ACCTGGCAAGCTCTTATGGATAATCCATATGATGTTAAAGAACTTATTCCTGAATTCTTCTATTTCCCAGAGTTTTTGGAAAATCAAAAT
CAATTTAACTTGGGTCGTCTACAGATTTCCAAAGAATTAGTAAATGATGTCATTCTCCCGAAATGGGCTAAATCAGCTGAAGATTTCATC
TATAAACATAGGAAAGCTTTGGAGTCTGAATATGTTTCAGCTCATCTTCATGAATGGATAGATCTGATCTTTGGCTATAAACAGAGGGGA
CCAGCTGCAGTAGAGGCACTCAACGTTTTCTATTATTGTAGTTATGAAGGAGCTGTGGATCTGGATGCCTTAACAGATGAGAAAGAAAGA
AAAGCCTTAGAAGGGATGATTAATAATTTTGGGCAAACACCCTGTCAATTATTAAAGGAACCACACCCTCCAAGATTATCAGCAGAAGAA
GCAGTGCAGAAGCCAACCAAAATAGACACTTCAACCCTAAACCTGTTTCAACACCTTCCTGAACTCAAGTCATTTTTTATAGAGGGGATT
AGTGATGGTATTCCACTATTAAAGGCCACCATCCCCAAAAATCAGTATCGTTCTTTTATGTCTCAAGGCAGCCCTGAGTTACTGATAACA
ATAAGCATGAATTATGTTATTGGAACCCATGGATGGTTGCCTTATGACAGAAACATTTCTAATTACTTTACATTCATCAAGGATCAAACT
GTGACAAATCCAAAAACTCAGCGCAGTATAAATGGTTCTTTTGCTCCCGGGCTAGAGATCACTTCTAAGCTATTTGTAGTATCACATGAT
GCAAAGTTGCTCTTCAGTGCTGGATACTGGGATAATAGCATTCAAGTGATGTCACTTACAAAAGGCAAAATTATCTCACACATCATCCGG
CATATGGATATTGTGACTTGCTTAGCTACAGATTACTGTGGAATACATTTGATTTCTGGTTCCAGAGATACTACATGTATGATATGGCAA
ATAACACAACAGTCTGAACAACCCAGTCCTGCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTTCACACCATCCCAGACCAGGCAACAAGGT
CCTTTGAGGTCTATAATGAAAGATCTGCATTCTGATGACAATGAGGAGGAATCAGATGAAGTGGAGGATAACGACAATGACTCTGAAATG
GAGAGGCCTGTAAATAGAGGAGGCAGCCGAAGTCGCAGAGTTAGCTTAAGTGATGGCAGCGATAGTGAAAGCAGTTCTGCTTCTTCACCC
CTACATCACGAACCTCCACCACCCTTACTAAAAACCAACAACAACCAGATTCTTGAAGTGAAAAGTCCAATAAAGCAAAGCAAATCAGAT
AAGCAAATAAAGAATGGTGAATGTGACAAGGCATACCTAGATGAACTGGTAGAGCTTCACAGAAGGTTAATGACATTGAGAGAAAGACAC
ATTCTGCAGCAGATCGTGAACCTTATAGAAGAAACTGGACACTTTCATATCACAAACACAACATTTGATTTTGATCTTTGCTCGCTGGAC
AAAACCACAGTCCGTAAACTACAGAGTTACCTGGAAACATCTGGAACATCCTGAGGATATAACAACTGGATGCATCAAGAACTATTGTGT
TTTTTTTTTTTGGTTTTTTTTTTTTTTGGTTGTGATTTTTTGTTCTTGTTGTTTATATGAAAACACTCAAAATGATGCAACCAAAAGGGA
AAAAATAAAAATCAAACAACCTTCAGCTTTATTTTTCTTTAAAGCCAGTCATCATCTCTTGATAAAGGAGAGGTTAAAGCAAACCAGCCT
CAGCGGACCACTCTTCTCTCCAAGGAAATCCCCGGGAAGAGTTAGCCTGGATAGCCTTGAAAACAAACAAATCAAACACAACACAAGAAA
ACTCAAAGAATGTGTATGGTATCATGTATCTCTCTGTGGTGGTTCATTCCACAGGACGAATGCATATTCAACACACTGCCTTATTACATA
ACTGATCTATTTATTATCGCATACAGATATTCTAAGTCGTTGAGGGAATGACACCATCAGACATTATAAGTACTTGGTCCCGTGGATGCT
CTTTCAATGCAGCACCCTTGCCATCCCAAGCCCAGTGACCTTACTCGTATACCGTGCCACTTTCCACCAACTTTTTCCAAGTCCTTTAAC
TCGTTGCAGTCTGTATTTTCCACCTTTTGTTTTTCCAGTTCCAGGACACAGATTATCAACTGGGGGGACCAAATAGCCACCTTGATTTTC
TTCTTTGTGGTCTTTTTCCTGAAAGTTGGGGCCCAGTCCTTGGCTGTATCCATGTAATGATCTTGGACCATGGTAGAAAATGCACCAAAT
AGGATCATATGAATTGCTGTCTAGCCTTAGTCAATAAACTTGTAGGACTTTTAAACAAAAGTGTACCTGTAAATGTCCTGAATCCAGCAT
TGTTGAGCTGTCATCAACATTCTTGTGTCTGTTTTACTGTTACAATATTAGGTGAATATGGAAGTAAAGGCATTCCACAGGATCATCATT
TAAAAAAAAAGAATTCTGGTCCTGTTTTCTAAAAAAAAAAACTGTTGTAGAAATTCTTAATTTGGATCTATTTATTAGTCAGAGTTTCAG
CTTTCTTCAGCTGCCAGTGTGTTACTCATCTTTATCCTAAAAATCTGGAATCAGAGATTTTTGTTTGTTCACATATGATTCTCTTAGACA
CTTTTATATTTGAAAAAATTAAAATCTTTCTTTGGGGAAAAATTCTTGGTTATTCTGCCATAACAGATTATGTATTAACTTGTAGATTCA
GTGGTTCAATACCTGTTTAGTTGCTTGCTAATATTTCCAGAAGGATTTCTTGTATTGGTGAAAGACGGTTGGGGATGGGGGGATTTTTTT
GTTCTTGTTGTACCCTTGTTTTGAAACTAGAAATCTGTCCTGTGGCATGCAAAAGAAAGCAAATTATTTTTAAAAGAAAAAAACCAAAGT
ACTTTTGGTGTCATTATTCCATCTTCTCCATAAGTGGAGAAATGAAAAGTAAGAACAGCTCATCTTCAAAGTTTTTACTAGAAATTCAGC
CGAAAAGAAGAGAAATGAAGAAATACTTCTGGATCCAAAGGTTCGTCACTGGATCAGCCTTAAGAAAGTCTCTATGTGTGCTAATAGACC
AGTATCTCCCTTGTTTGTTCCCATGCCAGATGCTGTCTTTTCATACAGAGATTAACTAGTGTCTGTACAGAAAATGGTCTTTCCAGACCC
ATTCTTTTGGGCAGTTATATAAATGCAGATTGATAATGGAGTTATTTCTGCATTTTAAAAAGGGGATTTTTTACACTGTTTCTTTCTATC
CAAAGAAACTATTTTTCCTTTAAAAAATTATAATACAGCCATGCTCCTTGTAAATTATTTCTCTGAAGCGTCCTCCCAGAGGACAAGTGT
ACTTTCTCAATAATGTTATGATTCTTAATGACGATTGGCATGAACCGTACTTGAAGCATTTGTTGTATTGTCCACTTCTTGATGTGCAGA
GAAACTTTGAGTCATTTTGGACATTAGGTGATTGATGAATTGTGTGGTTTCAGTTGCGTTTTGTTTTTAACTTTATAGCTGGAAGGGGAG
GGTAATGTTTATATGGAAATGTTGCAAATTTTTAAAATATTTTAAAATTTCTAACTGCTAACACATATTCTGATCAAGCCAGAAGTTTAT
GTGATTTAATATATCTGTGTAGTTTAACTAGAAACGTATATATGTAGTTTGGGCCATTTTTATTTCTGTAACTAAATTGTGGGGCAAAAA
ATATGATTTGCCAATGTAAAAATTTTTTCCTTTAAGTTACTAACCAAGAAGCTAGGTAAGATAAGAAATGACCAAACAAAAATAATGATA
AGAAGGACAGCTATTATATGATAAACTTTAGACTTGAAAATTAGGTAATAAAGTTAATTTCTTCAGAATATCCTAAAATGTAAGTTTGTA
AATTGATAAAGTTCAGAAAAACTTATCCATCTTCTACTCATCAAGATAGCAAAGTAAGTTTTTCACAAAATTAAGACTGAGAGTTACGTT
ATTTTTTTTGAAGTGGTAATCTTGCTCTCATCTAATTTTTAAATACAGAAATAAAAAGATCCCTTTGAATTAATTTCAAGTAGTTTTAAT
ACCTCTCTTAAAGTAACCCCTTCAGTTCTGTCACATTTATATACACCCAACTTTGAAGCCTATTAAGAATATCTTTGACATGTGAGTACC
CTAACAGTGGCTCTGGTTTCTTAAGCACAAAGGGAAAATGGCAGGGTTTAATTTCTTTGGTGTACATATATAAATAGATGTTTCAAATAA
AATTAATTGGGTAAATGTGAATATGGTTTGAACCAGCCAGAGTATGATAAACTTTTAAAAAATTTTTCCTCAGTGATCAGCCAGGGGAAA
AAATATATGTACAGAGCTCCTGCCCCTCTGCCCCCTTATAACTTAGCTTTTGCCTCTGGTTTTGCAGCAGGATGTGTGTTGGTGGGTTTG
GGGTTCCTTCTGTCTTCGGATGTAACAGTCATGTTAGCAACAATATTTTGCAGTTACTTCACCATCCTCAGCATAATCTGCCTCTCTCTC
AATCTTAATACAGACAAATAGGTATGTCTATAAATGCGTTCATATAGTGTCAAGGTAGGGAAGACTATAAAAACTTCAGATCAGGAAAAA
AATATCTCTTAAGAGAGTGTCTTAAACATTTTAAATTGCTAGGCAATTTAAATCTCTCTAATCTGAATATTCACCTTTTGGTGGAAAGAG
CCAGTAATATTGGTTTTCTTCCACTAAAAAGTTTCTTCAAAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCCGATATCTTTTACAG
GCCCACCTAATCTTTAAAAAAAAGAGAAGAAACAATTTTAGGCCTGTATAACATCCTATTTACTACTTCAAGCTCCACAAATGTAGTTAA
TATATTTGTTTAAGAGAGACTTTACTCTTAAATGTTTTAACTTTGCCTACTTAATGGAGTTGGATGTCCAGTGTTGGAAACAGTCAGTGT
CTGTTTGGTGGCTCGTGTTTATTTTTGTCACTGTAGAAGTGATCTGCTCTGGAGTAATTTGCTGTATGCTTATTACTTTCCACCTTTAGC
GTTTTGTGTACTAATGCTATGTACTGCTCCTATATTTATATATACATATATATATATATATACACATATATATTATCAGAGTAATCTTGC
TTTGGACTGTTGCTCTAAAACTATGAATATGATGTAGAGACTACTACAGCTGCAGTGAATGTTAAGGAGTCAATTCCCATGGTTTAGTTT
AGTCTCGGGCTGGAAGTCTACATCTTTTGACCTCTTTTGTTTTATATGATGCTTTTTATTATGTAGGCACTGCCATCCCTGAATATTCCT
TGTAAAGATGCAGTGAAGAAGTCAATTTAAAAGGAAGACAAAGCCACCGCTGTCTGTAAACTGTAAATGTGTATTTTGGCACTTGTACTC
CAGTATTCTGAAAATAGAGTTATGATGGAAATGCTGACAGATCCTTAATGGTGGCCAGAGCTACCATGCAGTGCAAAAATAAATTAAGTG
AAAATGTATTATTGAGATTAACAGTGCAAGGCCAATACATTTTATAAATCTGTCAGTATCTTTTTAATGGACTGTGTATGTGTAGTTATG
TTGAAAGATACATTGTGTATGTGTACATGCTTTTGTGTGAATTCAAGGCACACTGTAAGATGTATTTCCCTTCTCTAAAATCCATGTTGA
AATGTAAGTACAGATTGATAGAAATAGGTGTTTTACTTAAACTCATATAATCTGTTTCAGCACCTTTTTTAAAATGTATAATTGTACTGA
TTTGCTGAGAGTCATTTGACCAAAGTTTGGCTTTATTTTGCATACAGGAAAAATTAGCCCCTAGCCTTTTCTCAAGAAGTGATGCTGTTT
CTAAAGAAGAATAGATGGGGAGATCTGAGACATCCAGAGAGAGGACAATGTGTCCAAAACCAGCTGAAGGCAGAGAGTCCATGCCTCATT
CATTTTAGGAGTCCCTCATGTCTAACACCATCTTCTGTGTCCTAAAGCCAGTATATATATAATATTTTTAAAACTCTGCAAAGATTGGAA
CAAGAAGTGGTGGGATACATTTTTTGGCATAAACTGGGCTATGTGTGCCCGGTATTTTTTCTTTCCCCCCTATTTCTTTGGAGGGTTTTG
TTCAGAAACAATGTGCTATAGCCAGAGAGAGTCGATCTTACAAAGTCCCTGCATTTACTTTCACAGCAAGAACTGCTACCTTGATTAGAC

>57415_57415_1_NBEAL1-MLLT3_NBEAL1_chr2_204067504_ENST00000449802_MLLT3_chr9_20365742_ENST00000380338_length(amino acids)=2666AA_BP=2473
MASRERLFELWMLYCTKKDPDYLKLWLDTFVSSYEQFLDVDFEKLPTRVDDMPPGISLLPDNILQVLRIQLLQCVQKMADGLEEQQQALS
ILLVKFFIILCRNLSNVEEIGTCSYINYVITMTTLYIQQLKSKKKEKEMADQTCIEEFVIHALAFCESLYDPYRNWRHRISGRILSTVEK
SRQKYKPASLTVEFVPFFYQCFQESEHLKESLKCCLLHLFGAIVAGGQRNALQAISPATMEVLMRVLADCDSWEDGDPEEVGRKAELTLK
CLTEVVHILLSSNSDQRQVETSTILENYFKLLNSDHSALPNQRRSRQWENRFIALQIKMLNTITAMLDCTDRPVLQAIFLNSNCFEHLIR
LLQNCKVFQGQLDCLAISTIQALTAVMNKSPAAKEVFKERIGYTHMLEVLKSLGQPPLELLKELMNMAVEGDHTSVGILGISNVQPLLLL
IQWLPELQSHDLQIFISDWLKRICCINRQSRTTCVNANMGIRIIETLDLHSSLHQTCAENLIAIHGSLGSQSVSSEEIRRLLRLLRVDES
ESVHPYVTPVTRAILTMARKLSLESALQYFNLSHSMAGISVPPIQKWPGSAFSFSAWFCLDQDQLTLGIANKGGKRKQLYSFFTGSGMGF
EAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLWHNITVVHMPGKRPFGQSFVYIYDNGQQKVSAPLRFPAMNEPFTSCCIGSAGQRTT
TPPPSQIPDPPFSSPITPHRTSFGGILSSASWGGTIEKSKLITKLISAGTQDSEWGCPTSLEGQLGSVIIFYEPLQPPQVKALYLAGPNC
LSPWKCQESDMADLPGNILLYYTAKACKNSICLDLSTNCLHGRLTGNKVVNWDIKDIINCIGGLNVLFPLLEQISHFSEGQIPEEKNEST
VPESVTPVEGDWLVWTSTKASESRLERNLVATFILIVKHFIQRHPINQGNLIHSHGVATLGALLQKVPSTLMDVNVLMAVQLLIEQVSLE
KNMQLLQQMYQYLLFDFRIWNRGDFPFRIGHIQYLSTIIKDSRRVFRKKYGVQFLLDTLRIYYGNGCKYNELSLDDIRTIRTSLYGLIKY
FLCKGGSHEEIQSIMGYIAATNEEEQLFGILDVLFSLLRTSPTRGQLFLLLFEPGNADILYALLLNQKYSDRLREIIFKIMEQMLKCTNV
YERSKQHIRLREVGYSGLGLLLNEALVNTSLIKNLTHQIINTDPVINFKDLLSVVYISHRAHINVRVAICRKVLQILQFQPDAAHQISQQ
VGWQDTLVRLFLKAKFENGNTLHKHSRAVLMKDNDKNMSTEDTKKNSDEKTDEEKITSFASANVSSDQWSLEDRHSLDSNTPLFPEDSSV
GELSFKSENQEEFWHSNPSHLSLDLSGIDSCEMSDSGSQVPDSLPSTPSPVESTKSFSVHSDRESSITNDMGFSDDFSLLESQERCEEEL
LQLLTHILNYVMCKGLEKSDDDTWIERGQVFSALSKPGISSELLRPSDEIKLTLLQKMLEWAISENREAKTNPVTAENAFRLVLIIQDFL
QSEGLVNSNMWTEKLLEDMMLLFDCLSVCYSESPVWVKLSQIQIQLLLGFIGRGNLQVCAMASAKLNTLLQTKVIENQDEACYILGKLEH
VLSQSIKEQTEIYSFLIPLVRTLVSKIYELLFMNLHLPSLPFTNGSSSFFEDFQEYCNSNEWQVYIEKYIVPYMKQYEAHTFYDGHENMA
LYWKDCYEALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWKAIQLYLTCERGPWAKRKQNPIHWK
LANVENYSRMRLKLVPNYNFKTHEEASALRDNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLDLPEEDITARVNVDEKEEQDQKEKLVL
MEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHSQIREIHLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLL
SLHSPNSYYGSRSPQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPIGVVNE
KNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFY
FPEFLENQNQFNLGRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDL
DALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFMS
QGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPGLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTK
GKIISHIIRHMDIVTCLATDYCGIHLISGSRDTTCMIWQITQQSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEV
EDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHR

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Fusion Gene PPI Analysis for NBEAL1-MLLT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NBEAL1-MLLT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NBEAL1-MLLT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource