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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NBN-SLC26A7 (FusionGDB2 ID:57440)

Fusion Gene Summary for NBN-SLC26A7

check button Fusion gene summary
Fusion gene informationFusion gene name: NBN-SLC26A7
Fusion gene ID: 57440
HgeneTgene
Gene symbol

NBN

SLC26A7

Gene ID

9048

115111

Gene namearteminsolute carrier family 26 member 7
SynonymsART|ENOVIN|EVN|NBNSUT2
Cytomap

1p34.1

8q21.3

Type of geneprotein-codingprotein-coding
Descriptionarteminneublastinanion exchange transportersolute carrier family 26 (anion exchanger), member 7solute carrier family 6 member 7sulfate anion transporter
Modification date2020031320200313
UniProtAcc

O60934

.
Ensembl transtripts involved in fusion geneENST00000265433, ENST00000409330, 
ENST00000520249, ENST00000276609, 
ENST00000309536, ENST00000523719, 
Fusion gene scores* DoF score4 X 4 X 4=649 X 8 X 6=432
# samples 49
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NBN [Title/Abstract] AND SLC26A7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNBN(90994950)-SLC26A7(92406025), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC26A7

GO:0006820

anion transport

11834742

TgeneSLC26A7

GO:0006821

chloride transport

1183472

TgeneSLC26A7

GO:0008272

sulfate transport

1183472

TgeneSLC26A7

GO:0019532

oxalate transport

1183472


check buttonFusion gene breakpoints across NBN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC26A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-RE-A7BO-01ANBNchr8

90994950

-SLC26A7chr8

92406025

+


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Fusion Gene ORF analysis for NBN-SLC26A7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000265433ENST00000520249NBNchr8

90994950

-SLC26A7chr8

92406025

+
5UTR-3CDSENST00000409330ENST00000276609NBNchr8

90994950

-SLC26A7chr8

92406025

+
5UTR-3CDSENST00000409330ENST00000309536NBNchr8

90994950

-SLC26A7chr8

92406025

+
5UTR-3CDSENST00000409330ENST00000523719NBNchr8

90994950

-SLC26A7chr8

92406025

+
5UTR-3UTRENST00000409330ENST00000520249NBNchr8

90994950

-SLC26A7chr8

92406025

+
In-frameENST00000265433ENST00000276609NBNchr8

90994950

-SLC26A7chr8

92406025

+
In-frameENST00000265433ENST00000309536NBNchr8

90994950

-SLC26A7chr8

92406025

+
In-frameENST00000265433ENST00000523719NBNchr8

90994950

-SLC26A7chr8

92406025

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265433NBNchr890994950-ENST00000523719SLC26A7chr892406025+1180326155520121
ENST00000265433NBNchr890994950-ENST00000276609SLC26A7chr892406025+3574326155520121
ENST00000265433NBNchr890994950-ENST00000309536SLC26A7chr892406025+986326155541128

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265433ENST00000523719NBNchr890994950-SLC26A7chr892406025+0.0061735540.99382645
ENST00000265433ENST00000276609NBNchr890994950-SLC26A7chr892406025+0.0115850920.9884149
ENST00000265433ENST00000309536NBNchr890994950-SLC26A7chr892406025+0.0060417210.99395823

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Fusion Genomic Features for NBN-SLC26A7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NBNchr890994949-SLC26A7chr892406024+0.0010648620.99893516
NBNchr890994949-SLC26A7chr892406024+0.0010648620.99893516

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NBN-SLC26A7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:90994950/chr8:92406025)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBN

O60934

.
FUNCTION: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex. {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:9705271}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519641_656592657.0RegionMembrane targeting
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519641_656592664.0RegionMembrane targeting
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620641_656592657.0RegionMembrane targeting

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNBNchr8:90994950chr8:92406025ENST00000265433-216448_45157755.0Compositional biasNote=Poly-Gln
HgeneNBNchr8:90994950chr8:92406025ENST00000409330-216448_4510673.0Compositional biasNote=Poly-Gln
HgeneNBNchr8:90994950chr8:92406025ENST00000265433-216105_18157755.0DomainNote=BRCT
HgeneNBNchr8:90994950chr8:92406025ENST00000265433-21624_8357755.0DomainFHA
HgeneNBNchr8:90994950chr8:92406025ENST00000409330-216105_1810673.0DomainNote=BRCT
HgeneNBNchr8:90994950chr8:92406025ENST00000409330-21624_830673.0DomainFHA
HgeneNBNchr8:90994950chr8:92406025ENST00000265433-216461_46757755.0MotifNote=Nuclear localization signal
HgeneNBNchr8:90994950chr8:92406025ENST00000265433-216736_74357755.0MotifNote=EEXXXDDL motif
HgeneNBNchr8:90994950chr8:92406025ENST00000409330-216461_4670673.0MotifNote=Nuclear localization signal
HgeneNBNchr8:90994950chr8:92406025ENST00000409330-216736_7430673.0MotifNote=EEXXXDDL motif
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519492_641592657.0DomainSTAS
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519492_641592664.0DomainSTAS
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620492_641592657.0DomainSTAS
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519166_166592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519188_202592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST0000027660915191_75592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519224_227592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519249_254592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519276_306592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519328_343592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519365_383592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519426_448592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519470_656592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST00000276609151997_144592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519166_166592664.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519188_202592664.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST0000030953615191_75592664.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519224_227592664.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519249_254592664.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519276_306592664.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519328_343592664.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519365_383592664.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519426_448592664.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519470_656592664.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST00000309536151997_144592664.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620166_166592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620188_202592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST0000052371916201_75592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620224_227592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620249_254592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620276_306592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620328_343592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620365_383592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620426_448592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620470_656592657.0Topological domainCytoplasmic
TgeneSLC26A7chr8:90994950chr8:92406025ENST00000523719162097_144592657.0Topological domainExtracellular
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519145_165592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519167_187592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519203_223592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519228_248592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519255_275592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519307_327592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519344_364592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519384_404592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519405_425592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000002766091519449_469592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST00000276609151976_96592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519145_165592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519167_187592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519203_223592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519228_248592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519255_275592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519307_327592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519344_364592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519384_404592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519405_425592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000003095361519449_469592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST00000309536151976_96592664.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620145_165592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620167_187592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620203_223592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620228_248592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620255_275592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620307_327592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620344_364592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620384_404592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620405_425592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST000005237191620449_469592657.0TransmembraneHelical
TgeneSLC26A7chr8:90994950chr8:92406025ENST00000523719162076_96592657.0TransmembraneHelical


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Fusion Gene Sequence for NBN-SLC26A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57440_57440_1_NBN-SLC26A7_NBN_chr8_90994950_ENST00000265433_SLC26A7_chr8_92406025_ENST00000276609_length(transcript)=3574nt_BP=326nt
AAGTCGCACTCCCGCCTCATCCAAGGCAGCCTGCGTGGCTCCCGGGAGCGCGCACGTCCCGGAGCCCATGCCGACCGCAGGCGCCGTATC
CGCGCTCGTCTAGCAGCCCCGGTTACGCGGTTGCACGTCGGCCCCAGCCCTGAGGAGCCGGACCGATGTGGAAACTGCTGCCCGCCGCGG
GCCCGGCAGGAGGAGAACCATACAGACTTTTGACTGGCGTTGAGTACGTTGTTGGAAGGAAAAACTGTGCCATTCTGATTGAAAATGATC
AGTCGATCAGCCGAAATCATGCTGTGTTAACTGCTAACTTTTCTGTAACCAACCTGGTTTACATGGACTGTAAAGGCAGGAGTGTGGATG
TATTGTTAGCCCATTGTACAGCTTCCTTGATAAAAGCAATGACGTATTATGGAAACCTAGACTCAGAGAAACCAATTTTTTTTGAATCGG
TATCTGCTGCAATAAGTCATATCCATTCAAATAAGAATTTGAGCAAACTCAGTGACCACAGTGAAGTCTGAGACCCTTTTGTCACAGTAC
AGCTCTTGTCTTTACCAACTGCCTGAAGAGGCCATATGCTGGCATTTTGCACAACTTTTTGGTTGTTTAGATCCTACAGATGACCTCTGC
TACAATAAGTACGATGTGACTTAGTAACTGCATAGCAGTTGGAAAGAACTGCCAACTTTTTTTTCTCATTTTTGTTAGTAAGAAGATTCG
CTTAGTTATTTTATGTAAAAATCAGTATGTGTTTAGTTTTAGTGTACTGAAGGGTAAACATGGTTTTATTTTATTTTACCATATTATTTT
GTGTTGTTTTATTTCTATTGTGCTGTAAGTTGATGTTTAAAATTGAGAAATACTTTTGTCATAGGTAATTTGGAACATTTACAAGCCATT
TGTAAAATTTTAAGATAATCTGTAACTAATACATAAAAACAACTTAGCAAATGTGCCATTTTCACACAACTTCTCTCTGTATAGGCCTCT
GAAATATCAATAAGGCTAAATATTACTTTACACAGTAAGATGTGAAATTCACAAAAAGTAAACCAAACAAAACGAATGAAAAACTGGAAA
TAATTCGTTTCCATATCTTTCCATACATCCATTTCTGAAGTATTCAGGAATGTTTTCATAATCGAAAGAAACGGGTATCCAAATAAAACC
AAGTTCTTGACATTGGTCTGTTTTGCTGTGAATATTGGAAATGCTTAGGATCTTCAGACCCAATAGCTCTAATTTTAACATTTCTACCCA
ATAAGAGGCTCTGTTTTCCACTGAAGCTTTGTTGGAGAAAGAGAATATGAAAATTACACATTTTATAATTTTTAGATGAGAAAATACCAC
TAGCAGAATAGCTTTGTGCTATTCCAGTATAAGATGAACTGTAATAATTTTTGACTTCCCTATTTCAGAGATAGTCAATATAATATGTTT
ATCTATATCCATATGGATGGATAGGTAGGTAGATCTTCATAGATTTTTTTTTCTTTTGTTAGAGGAGAGCTTGATGTGATTATCTTCAAA
CCCACCAAACCAACAGGATAATTGACAAATAAACGCCATAGGCTAGGCTGAACTGTATGTTACTGTTTTCATGCTTATACATATATTTTC
AATCACATACAAGTACATAGAATTTCACATTTTAATTTAGCAAATTGATTTACCTAGGAAAAAATTATCACCTTCAAAGATAGGCATAGA
CACATAATTATGCTTAAGCTTTTAACAGCATTTTAACCGCTCTAAAAATTACCAGAGTAAGAAAAAGCTAGGTACTTTAAAGTGAGTTTG
AGAAACAAGTTGAAACTAAAATTAAAATACCAGCCATTTAGGTGCTTTCTCTGGCATCTATAAAAGTAAATTCTAGTGCCTGCCAAGTGA
TGGATTATAATGGTCTCTAGCAAATGTGTGGTAAACATTCATATGGCCATTAATTTTAACATTAAATCGTAGGTAGGGCAATGTAGTAAA
ATGAAAGAGAATTAAGAAAGGTTTTGAATTCTTATAACATATCCAGCCATTTCAATTTTGATTGAAATGAACTACAAAGAATAGTGTTTG
TCCCTATGGTAGCCTCAGTCTCTTTATCACTAACTTGGATTGAAATGAGTGAGGCCAACTCACATTCCCATCAAACACTCTTCCAAGGAA
AAGCAGAAGTAATAATTGGAGGTAAAGTTTCCTTAGAGAAAATAATTTTATTCTGCTTTGTCCAATTAAATTATTCCAATGGCGGATGGT
AATATTCACCATCTCTAATTCATTGGTCACTGGTAGGTAAGCATGAGTTAAGGAAAGTCAAAAATGAAAATATATTTTGCTGTGTATAAA
TTGATATTTTGCTATGCAACTCCTGTAATTGAATTTGTATAATGCAGGCACTTTCTAATTTATTAGAGATTATGGATCAGTTCTGACATT
AAAATCATAGTTAATTGATGGATGGTTTTTATAGTTTGTTGATAAAGTGGACACAGTATTGTCTGAGCAGTTATATTTTAATGCATTTCA
GTGTTTATAGTAGAAGTTTAGTGGATAAAACTTTAAGTCCAATAACTTGGGGGTCAAATGCTAATGTTTTATTCAATGTAAAGGAAGACC
AAACCATGTACCTTATGAAGACCTTTGTTTTAAGACTTCCACACACCAAGGCTACAATGACTGTTAACCTGGAGGAAGTCTCTGGTATGG
AGTTCTGAGAGCTTAAGAGCTAAACATGAGTTTAGACACACAAGATTCTAAAATGCAAATGTTTATTTTGAAGCAGGCATTGACAACACA
AAAACTGTGTAGTGGTCTTGATGCTGGATTGTTTCTAGAGTCACAATGAATTATTTTTATGAGATTACCTTATTTTTATATATGACAAAC
TACTTCTATAATGCTTATTATGGTAAAATAAAATTGGAAAAAATTAAAACTGACCTATAAGAGTGTTAAGGACCTAATAGAGTGACATAT
ATAAATTAAGCATAAAATATGTAACCAGGAAAAGACTGTTAACATTACATTTATGCAAATTAAATGCCCTTAAATTTCACCATTTGTCTT
TCATTTTAAAGGTTATTTGCTCCCGATTATATGATTCAAGTGTTATAAGTTTTAGCTTGAACTACTTTGCAGTAATTTATTTGACAGATC
TCTATTCTATAAATGTGTAATGTGATGAAGAAAGAGATCTTTCTTTTTTAATGAAAACATTAATGTGTTAATACCCTGTATGGATAATGC
TTGACATTTAGTGGTTTCCAAAATATATTAGTATATTGTTGAACATACATTATGCCTTAGAAATGCACATTCTGTATTTTGTGGGATGAT
AATCTAATTCAGTATAGAATATGCTGTTTGGCAATGAGTTTGTGGCCAGATTTCAAATAGGGAGTTAAGTGGTACTTTCACAATCCAAAG
ATTTTTAGTTAAAAATCATGTAGTCTAATATGCTGCAGTTATTTTTTTATATTTTTCAATGCATTTAATTATCTTTTTTATAATTCTTTG

>57440_57440_1_NBN-SLC26A7_NBN_chr8_90994950_ENST00000265433_SLC26A7_chr8_92406025_ENST00000276609_length(amino acids)=121AA_BP=57
MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDS

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>57440_57440_2_NBN-SLC26A7_NBN_chr8_90994950_ENST00000265433_SLC26A7_chr8_92406025_ENST00000309536_length(transcript)=986nt_BP=326nt
AAGTCGCACTCCCGCCTCATCCAAGGCAGCCTGCGTGGCTCCCGGGAGCGCGCACGTCCCGGAGCCCATGCCGACCGCAGGCGCCGTATC
CGCGCTCGTCTAGCAGCCCCGGTTACGCGGTTGCACGTCGGCCCCAGCCCTGAGGAGCCGGACCGATGTGGAAACTGCTGCCCGCCGCGG
GCCCGGCAGGAGGAGAACCATACAGACTTTTGACTGGCGTTGAGTACGTTGTTGGAAGGAAAAACTGTGCCATTCTGATTGAAAATGATC
AGTCGATCAGCCGAAATCATGCTGTGTTAACTGCTAACTTTTCTGTAACCAACCTGGTTTACATGGACTGTAAAGGCAGGAGTGTGGATG
TATTGTTAGCCCATTGTACAGCTTCCTTGATAAAAGCAATGACGTATTATGGAAACCTAGACTCAGAGAAACCAATTTTTTTTGAATCGG
TATCTGCTGCAATAAGTCATATCCATTCAAATAAGGCCAGTTATAAACTGTTGTTTGATAACTTGGATCTTCCAACAATGCCACCGCTCT
GAGGATTGGGTGGTTGCCTATCATTTGCAAACTGCTTACTTGTACAACAAATGCTTCTTCCAGGATCTACTGTCCTGGGGACTTGAATCC
ACCTTTCTCAAATATAAAAACTCTAAATATGGCCTTTTAAGTTTTTTCTGCTCTGATATCTTGCCTCTAAGCTTATATTGCCATCTTTGG
AAATACTATTTGTAGAATCTAGTGCTCACATGATCTGAAGTGTCAAAGTTATTTTACAAATGCTGGGCTTATGGTTTAGTTTTACAACTG
TTCTTAGAGCTTTAATTTCCTGCAATTTTTCCTTGAGTTTTGAATTGTTTTGCCTTTCCTCACCCCTAGAATAACATTTGGTGCCTCGCA

>57440_57440_2_NBN-SLC26A7_NBN_chr8_90994950_ENST00000265433_SLC26A7_chr8_92406025_ENST00000309536_length(amino acids)=128AA_BP=57
MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDS

--------------------------------------------------------------
>57440_57440_3_NBN-SLC26A7_NBN_chr8_90994950_ENST00000265433_SLC26A7_chr8_92406025_ENST00000523719_length(transcript)=1180nt_BP=326nt
AAGTCGCACTCCCGCCTCATCCAAGGCAGCCTGCGTGGCTCCCGGGAGCGCGCACGTCCCGGAGCCCATGCCGACCGCAGGCGCCGTATC
CGCGCTCGTCTAGCAGCCCCGGTTACGCGGTTGCACGTCGGCCCCAGCCCTGAGGAGCCGGACCGATGTGGAAACTGCTGCCCGCCGCGG
GCCCGGCAGGAGGAGAACCATACAGACTTTTGACTGGCGTTGAGTACGTTGTTGGAAGGAAAAACTGTGCCATTCTGATTGAAAATGATC
AGTCGATCAGCCGAAATCATGCTGTGTTAACTGCTAACTTTTCTGTAACCAACCTGGTTTACATGGACTGTAAAGGCAGGAGTGTGGATG
TATTGTTAGCCCATTGTACAGCTTCCTTGATAAAAGCAATGACGTATTATGGAAACCTAGACTCAGAGAAACCAATTTTTTTTGAATCGG
TATCTGCTGCAATAAGTCATATCCATTCAAATAAGAATTTGAGCAAACTCAGTGACCACAGTGAAGTCTGAGACCCTTTTGTCACAGTAC
AGCTCTTGTCTTTACCAACTGCCTGAAGAGGCCATATGCTGGCATTTTGCACAACTTTTTGGTTGTTTAGATCCTACAGATGACCTCTGC
TACAATAAGTACGATGTGACTTAGTAACTGCATAGCAGTTGGAAAGAACTGCCAACTTTTTTTTCTCATTTTTGTTAGTAAGAAGATTCG
CTTAGTTATTTTATGTAAAAATCAGTATGTGTTTAGTTTTAGTGTACTGAAGGGTAAACATGGTTTTATTTTATTTTACCATATTATTTT
GTGTTGTTTTATTTCTATTGTGCTGTAAGTTGATGTTTAAAATTGAGAAATACTTTTGTCATAGGTAATTTGGAACATTTACAAGCCATT
TGTAAAATTTTAAGATAATCTGTAACTAATACATAAAAACAACTTAGCAAATGTGCCATTTTCACACAACTTCTCTCTGTATAGGCCTCT
GAAATATCAATAAGGCTAAATATTACTTTACACAGTAAGATGTGAAATTCACAAAAAGTAAACCAAACAAAACGAATGAAAAACTGGAAA
TAATTCGTTTCCATATCTTTCCATACATCCATTTCTGAAGTATTCAGGAATGTTTTCATAATCGAAAGAAACGGGTATCCAAATAAAACC

>57440_57440_3_NBN-SLC26A7_NBN_chr8_90994950_ENST00000265433_SLC26A7_chr8_92406025_ENST00000523719_length(amino acids)=121AA_BP=57
MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NBN-SLC26A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNBNchr8:90994950chr8:92406025ENST00000265433-216221_40257.0755.0MTOR%2C MAPKAP1 and RICTOR
HgeneNBNchr8:90994950chr8:92406025ENST00000409330-216221_4020673.0MTOR%2C MAPKAP1 and RICTOR


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NBN-SLC26A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NBN-SLC26A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource